Relevant bibliographies by topics / Heterocycles Fused

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Academic literature on the topic 'Heterocycles Fused'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Heterocycles Fused"

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Li, Wen, Jinyang Zhang, Min Wang, et al. "Pyrimidine-fused Dinitrogenous Penta-heterocycles as a Privileged Scaffold for Anti-Cancer Drug Discovery." Current Topics in Medicinal Chemistry 22, no. 4 (2022): 284–304. http://dx.doi.org/10.2174/1568026622666220111143949.

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Abstract: Pyrimidine-fused derivatives that are the inextricable part of DNA and RNA play a key role in the normal life cycle of cells. Pyrimidine-fused dinitrogenous penta-heterocycles, including pyrazolopyrimidines and imidazopyrimidines are a special class of pyrimidine-fused compounds contributing to an important portion in anti-cancer drug discovery, which has been discovered as the core structure for promising anti-cancer agents used in the clinic or clinical evaluations. Pyrimidine-fused dinitrogenous penta-heterocycles have become one privileged scaffold for anti-cancer drug discovery.
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Hoffman, Gavin R., and Allen M. Schoffstall. "Syntheses and Applications of 1,2,3-Triazole-Fused Pyrazines and Pyridazines." Molecules 27, no. 15 (2022): 4681. http://dx.doi.org/10.3390/molecules27154681.

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Pyrazines and pyridazines fused to 1,2,3-triazoles comprise a set of heterocycles obtained through a variety of synthetic routes. Two typical modes of constructing these heterocyclic ring systems are cyclizing a heterocyclic diamine with a nitrite or reacting hydrazine hydrate with dicarbonyl 1,2,3-triazoles. Several unique methods are known, particularly for the synthesis of 1,2,3-triazolo[1,5-a]pyrazines and their benzo-fused quinoxaline and quinoxalinone-containing analogs. Recent applications detail the use of these heterocycles in medicinal chemistry (c-Met inhibition or GABAA modulating
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Masdeu, Carme, Maria Fuertes, Endika Martin-Encinas, et al. "Fused 1,5-Naphthyridines: Synthetic Tools and Applications." Molecules 25, no. 15 (2020): 3508. http://dx.doi.org/10.3390/molecules25153508.

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Heterocyclic nitrogen compounds, including fused 1,5-naphthyridines, have versatile applications in the fields of synthetic organic chemistry and play an important role in the field of medicinal chemistry, as many of them have a wide range of biological activities. In this review, a wide range of synthetic protocols for the construction of this scaffold are presented. For example, Friedländer, Skraup, Semmlere-Wolff, and hetero-Diels-Alder, among others, are well known classical synthetic protocols used for the construction of the main 1,5-naphthyridine scaffold. These syntheses are classified
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Veeranki, Krishna Chaitanya, Jalapathi Pochampally, and Ravi Chander Maroju. "Synthesis of Novel Biaryl Fused Thiazolo[3,2-b][1,2,4]triazol-2-amines from Thiazole Amine Involving Suzuki Coupling Reaction under Microwave Irradiation." Asian Journal of Chemistry 35, no. 2 (2023): 431–34. http://dx.doi.org/10.14233/ajchem.2023.26998.

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Novel series of fused heterocycles in which amino triazole fused to biphenyl thiazole were synthesized in a multistep reaction starting from 2-aminothiazole. The amino compound with ethoxy carbonyl isothiocyanate afforded the ethyl carbamate thiomide derivative of thiazole, which further underwent intramolecular cyclization with hydroxyl amine hydrochloride in presence of DIPEA to furnish the fused thiazolotriazole amine. Haloaryl group in the fused heterocycle under Suzuki coupling condition afforded biphenyl derivatives of fused thiazolotriazole amines. All the synthesized compounds were con
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Li, Xianwei, Tianzhang Wang, Yu-Jing Lu, Shaomin Ji, Yanping Huo, and Bifu Liu. "Copper-catalyzed oxidative multicomponent reaction: synthesis of imidazo fused heterocycles with molecular oxygen." Organic & Biomolecular Chemistry 16, no. 39 (2018): 7143–51. http://dx.doi.org/10.1039/c8ob01532e.

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An oxidative cascade that involves multicomponent reaction comprising a terminal alkyne, 2-amino N-heterocycle, benzyl or allylic bromide with molecular oxygen, delivering densely functionalized imidazo fused heterocycles, is achieved.
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Puebla, Pilar, Zoila Honores, Manuel Medarde, Lourdes Morán, Esther Caballero, and Arturo San Feliciano. "Synthesis of fused heterocycles from heterocyclic enaminones." Tetrahedron 55, no. 25 (1999): 7915–22. http://dx.doi.org/10.1016/s0040-4020(99)00401-9.

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Wang, Hengshuai, Shengchao Jiao, Kerong Chen, et al. "Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions." Beilstein Journal of Organic Chemistry 11 (March 30, 2015): 416–24. http://dx.doi.org/10.3762/bjoc.11.47.

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We report a synthetic methodology for the construction of the fused heterocyclic compounds pyrido[2,1-b]quinazolin-9(1H)-ones and pyrrolo[2,1-b]quinazolin-9(1H)-ones through an AgOTf-catalyzed intramolecular alkyne hydroamination reaction. The methodology is applicable to a wide scope of substrates and produces a series of fused quinazolinone heterocycles in good to excellent yields.
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Hitesh, Hitesh Amrutlal. "Synthesis, Characterization and Antifungal Activity of Novel Thiazolo-Pyrimidine Fused Heterocycles." ECS Transactions 107, no. 1 (2022): 1165–72. http://dx.doi.org/10.1149/10701.1165ecst.

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In medicinal chemistry, nitrogen and sulphur containing heterocyclic compounds are well known for their therapeutic properties.(1) Among them thiazole and pyrimidine derivatives possess diverse pharmaceutical activities.(2,3) More particularly thiazolo-pyrimidine fused shows various therapeutically activities like, anticancer, antimicrobial, antibacterial effects, antiviral ,etc (4-7). Such type of fused heterocycles containing furan and naphthalene moieties has not been developed. Thus, the aim of the present work to study the novel fused thiazolo-pyrimidine derivatives, their characterizatio
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de Ceuninck van Capelle, Lillian A., James M. Macdonald, and Christopher J. T. Hyland. "Stereogenic and conformational properties of medium-ring benzo-fused N-heterocycle atropisomers." Organic & Biomolecular Chemistry 19, no. 33 (2021): 7098–115. http://dx.doi.org/10.1039/d1ob00836f.

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By examining the various contributions to the conformational and stereogenic stability of medium-sized benzo-fused N-heterocyclic atropisomers, this review serves to aid the design, synthesis and study of these pharmaceutically relevant heterocycles.
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Bassam A. Hassan, Hameedi N Nasera, and Maitham M. Abdulridha. "Synthesis and antimicrobial evaluation of fused heterocyclic compound [1,2,4] triazolo [4,3-b][1,2,4,5] tetra zine." International Journal of Research in Pharmaceutical Sciences 10, no. 2 (2019): 1254–58. http://dx.doi.org/10.26452/ijrps.v10i2.417.

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Nitrogen-containing, heterocycles, have special importance and vital, role in the discovery of effective bioactive, agents in the pharmaceutical, industry. The present article reports the synthesis of new fused, heterocycles triazolotetrazine by cyclo condensation, reaction as shown in scheme(1). The structures formula of synthesized compounds newly was evaluated by Ft-IR,1H-NMR spectrum, and C, H, N elemental analysis. Antimicrobial activity of triazolotetrazine studied against some pathogenic bacterial strains isolated from patients like Acinetobacter, Aeromonas, E. coli, Klebsiella, Staphyl
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Dissertations / Theses on the topic "Heterocycles Fused"

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Stevenson, Elizabeth. "Pyrolytic syntheses of fused bridgehead nitrogen heterocycles." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/13016.

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There are two distinct areas of work in this thesis, both involving pyrolytic syntheses of nitrogen heterocycles. The first area of work extends a previous synthesis of 1<I>H</I>-azepin-3(2<I>H</I>)-ones to examples with a fused ring in the 1,2-position. The synthetic strategy for such azepinones involved preparation of enaminals incorporating cyclic amines with different ring sizes, then condensation of the enaminals with Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione). Flash Vacuum Pyrolysis (F.V.P.) of the Meldrum's acid derivative gave the fused azepinone with dicyclopentadienone forme
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Fletcher, Rodney Justin. "Radical cyclisation in routes to cis-fused heterocycles." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283701.

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Hitchings, G. J. "The synthesis of fused heterocycles containing bridgehead-nitrogen." Thesis, University of York, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383838.

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Tyas, Richard G. "New pyrolytic routes to fused bridgehead nitrogen heterocycles." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/11477.

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Under flash vacuum pyrolysis (FVP) conditions <i>C-</i>unsubstituted imidazole <i>N-</i>propenoate ester derivatives give 78±5:22±5 mixtures of pyrrolo[1,2-<i>a</i>]amidazol-5-one and pyrrolo[1,2<i>-c</i>]imidazol-5-ones. The mechanism involves a cascade process initiated by 1,5-sigmatropic shift of the substituent. Substitution of the imidazole <i>N</i>-propenoate ester at the 2-position or 4,5-positons of the heterocycle allows exclusive access to the pyrrolo[1,2-<i>c</i>]imidazol-5-one and pyrrolo[1,2-<i>a</i>]amidazol-5-one systems respectively upon FVP. Ring-opening of the pyrrolo[1,2-<i>
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Ergun, Merve. "Development Of New Synthetic Methodologies For Furan Fused Heterocycles." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615337/index.pdf.

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Furopyranones and furopyrrolones are furan-fused bicyclic heterocycles containing pyranone and pyrrolone framework respectively. Many natural products and pharmaceutical agents include these core structures. In this study, new synthetic methodologies were developed for the synthesis of furopyranone and furopyrrolone derivatives. In the first section of this thesis, methyl 2-(2-methoxy-2-oxoethyl)-3-furoate was hydrolyzed forming 2-(carboxymethyl)-3-furoic acid which underwent intramolecular cyclization reaction using two different methodologies forming furopyranone derivatives. In the second p
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Tice, Nathan Charles. "THE SYNTHESIS, STRUCTURE, AND REACTIVITY OF SOME ORGANOMETALLIC-FUSED HETEROCYCLES." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/297.

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The synthesis, structure, and reactivity of some organometallic-fusedheterocycles were studied. This work was divided into three parts: first,thiapentalenyl tricarbonyl manganese complexes [Mn(CO)3{??5-SC7H3-1,3-(R)2}]were synthesized employing thiation on diacyl precursors; second, attempts toform the 5,5-fused ring pyrrole analogs to the thiapentalenyl complexes led to theformation of various amine and imine ligands and manganese complexes, but notthe desired ring-closed pyrroles; third, reductive amination on a ferrocenylmonoaldehyde substrate led to the formation of di(N-(ferrocenylmethyl)
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Sadiq, Samina. "Studies of some fused-ring heterocycles and 2,6-Diarylpyridine derivatives." Thesis, Brunel University, 1999. http://bura.brunel.ac.uk/handle/2438/7281.

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This work reported is divided into two parts: the first part deals with quinoxaline derivatives and includes the preparation and characterisation of novel linear tricyclic quinones 1,4-diazanthracen-9,10-diones, (54) and (55). The reaction of diazanaphthoquinones and 1-acetyl-1,3-butadiene are used to produce these quinones through the Diels-Alder reaction. In addition hexaazapentacyclic 5,6,7,12,13, 14-hexaazapentacene was prepared by the reaction ofbis(2-chloroquinoxalin-3-yl)sulfide with thioxamide and the reaction of the sulfide with amines was investigated. Two different approaches to 6,1
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Ladwa, Mitesh Mohan. "A radical approach towards the synthesis of fused nitrogen heterocycles." Thesis, University of Aberdeen, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430405.

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A literature review of the chemistry of homolytic aromatic substitution is presented with particular emphasis to the formation of fused heterocyclic systems. A series of five-membered spirocyclic 5-azaoxindole-ring systems have been synthesised by generating an alkyl radical that underwent an intramolecular radical cyclisation at the 3-positon of a pyridine ring and was followed by oxidation giving rise to a mix of fused pyridine ring systems.  However, numerous problems were encountered with this investigation, not least the stability of the alpha brominated carbonyl radical precursor, conseq
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Boyle, Rosemary. "Synthesis, structure and stereochemistry of metabolites from benzo-fused oxygen heterocycles." Thesis, Queen's University Belfast, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333789.

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Torrisi, Elena. "Intramolecular 1,3 dipolar cycloaddition: a powerful tool to synthetize fused heterocycles." Doctoral thesis, Urbino, 2021. http://hdl.handle.net/11576/2689496.

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Books on the topic "Heterocycles Fused"

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Ellis, G. P. Synthesis of fused heterocycles. Wiley, 1987.

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Ellis, G. P. Synthesis of fused heterocycles. Wiley, 1987.

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Ellis, G. P. Synthesis of fused heterocycles : Part 2. Wiley, 1992.

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Lednicer, Daniel. The organic chemistry of drug synthesis. Wiley, 1995.

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Lednicer, Daniel. The organic chemistry of drug synthesis. Wiley, 1990.

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Delia, Thomas J. Miscellaneous fused pyrimidines. Wiley, 1992.

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Ellis, Gwynn P. Synthesis of Fused Heterocycles. Wiley & Sons, Incorporated, John, 2009.

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Ellis, Gwynn P. Chemistry of Heterocyclic Compounds, Synthesis of Fused Heterocycles. Wiley & Sons, Incorporated, John, 2008.

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Ellis, Gwynn P. Chemistry of Heterocyclic Compounds, Synthesis of Fused Heterocycles. Wiley & Sons, Incorporated, John, 2008.

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Ellis, Gwynn P. Synthesis of Fused Heterocycles, Part 2. Wiley & Sons, Incorporated, John, 2009.

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Book chapters on the topic "Heterocycles Fused"

1

Haas, Alois, Dieter Koschel, and Ulrich Niemann. "Fused Perfluorohalogenoorgano Nitrogen Heterocycles." In F Perfluorohalogenoorgano Compounds of Main Group Elements. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-662-07759-7_6.

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Kaur, Navjeet. "Five-Membered Fused N-Heterocycles." In Palladium Assisted Synthesis of Heterocycles. CRC Press, 2019. http://dx.doi.org/10.1201/9781351242615-3.

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Kaur, Navjeet. "Six-Membered Fused N-Heterocycles." In Palladium Assisted Synthesis of Heterocycles. CRC Press, 2019. http://dx.doi.org/10.1201/9781351242615-9.

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Kaur, Navjeet. "Five-Membered Fused N-Heterocycles." In Metals and Non-Metals. CRC Press, 2020. http://dx.doi.org/10.1201/9780429321580-3.

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Kaur, Navjeet. "Five-Membered Fused N,N-Heterocycles." In Metals and Non-Metals. CRC Press, 2020. http://dx.doi.org/10.1201/9780429321580-7.

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Dhanda, Nishu, Chetna Kumari, and Sudesh Kumar. "Synthesis and Biological Evaluation of Fused Thiazolotriazole and Imidazothiadiazole Scaffolds." In S-Heterocycles. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-4308-7_12.

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Teli, Pankaj, Hemant Kumar Rundla, Lokesh Kumar Agarwal, Dinesh Kumar Jangid, and Shikha Agarwal. "Synthesis and Biological Evaluation of Some Fused Pyrrolothiazoles, Pyrazolothiazoles, and Imidazothiazoles." In S-Heterocycles. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-4308-7_7.

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Kaur, Navjeet. "Five-Membered Poly and Fused O-Heterocycles." In Palladium Assisted Synthesis of Heterocycles. CRC Press, 2019. http://dx.doi.org/10.1201/9781351242615-5.

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Gupta, Radha Raman, Mahendra Kumar, and Vandana Gupta. "Benzo-Fused Five-Membered Heterocycles with One Heteroatom." In Heterocyclic Chemistry. Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-662-07757-3_3.

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Bagdi, Avik Kumar, and Alakananda Hajra. "Cross-Dehydrogenative Coupling in the Synthesis and Functionalization of Fused Imidazoheterocycles." In Heterocycles via Cross Dehydrogenative Coupling. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-9144-6_4.

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Conference papers on the topic "Heterocycles Fused"

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Stadlbaur, Wolfgang, Gerhard Hojas, and Werner Fiala. "Thermal Cyclization of 2-Hydrazonoacyl-3-oxo-heterocycles to Pyrazolo[4,3-c]fused Heterocycles." In The 2nd International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1998. http://dx.doi.org/10.3390/ecsoc-2-01669.

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Jung-Si Lee, K. Chang, Wen-Jwu Wang, and Gene-Miang Lee. "Preparatint, structural, and physical studies of TTM-TTF complexes with qnint, a quinone-type acceptor fused with sulfur-containing heterocycles." In International Conference on Science and Technology of Synthetic Metals. IEEE, 1994. http://dx.doi.org/10.1109/stsm.1994.835498.

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Amarandi, Roxana-Maria, Maria-Cristina Al-Matarneh, Lacramioara Popovici, et al. "Pyrrolo-fused heterocyclic derivatives: design, synthesis and anticancer evaluation." In New frontiers in natural product chemistry, scientific seminar with international participation. Institute of Chemistry, 2021. http://dx.doi.org/10.19261/nfnpc.2021.ab17.

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Bader, Mamoun M. "Theoretical investigation of the second- and third-order nonlinear optical properties of some fused heterocyclic aromatic compounds." In SPIE's International Symposium on Optical Science, Engineering, and Instrumentation, edited by Mark G. Kuzyk. SPIE, 1998. http://dx.doi.org/10.1117/12.328181.

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Gullapalli, Srinivas, Abhijit Roychowdhury, Tushar Khaladkar, et al. "Abstract 1701: EPL-1410, a novel fused heterocycle based orally active dual inhibitor of IDO1/TDO2, as a potential immune-oncology therapeutic." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1701.

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Meth, J. S., H. Vanherzeele, S. A. Jenekhe, and M. F. Roberts. "Nonlinear-optical studies of poly (p-phenylene benzobisthiazole) and its composites with nylon." In OSA Annual Meeting. Optica Publishing Group, 1990. http://dx.doi.org/10.1364/oam.1990.thaa5.

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Conjugated heterocyclic rigid rod polymers are of special interest as nonlinear optical (NLO) materials because of their robust physical properties, which include excellent mechanical strength and thermal stability.1 Recent advances1 in the solubilization and processing of these polymers make optical- quality thin films available for NLO measurements. This paper reports χ(3)-Pi-characterization of thin films of poly(p-phenylene benzo-bisthiazole) (PBZT) and PBZT/nylon molecular composites by third-harmonic generation (THG). Solutions of PBZT or PBZT/nylon 66 in Lewis acid (GaCl3 or AlCl3-nitro
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