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Journal articles on the topic 'Heterocyclic amino'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Luna, Isadora Silva, Rayssa Marques Duarte da Cruz, Ryldene Marques Duarte da Cruz, Rodrigo Santos Aquino de Araújo, and Francisco Jaime Bezerra Mendonça-Junior. "1,4-Dithiane-2,5-diol: A Versatile Synthon for the Synthesis of Sulfur-containing Heterocycles." Current Organic Synthesis 15, no. 8 (2018): 1026–42. http://dx.doi.org/10.2174/1570179415666180821154551.

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Background: 1,4-Dithiane-2,5-diol (1,4-DTD) is the stable dimer of α-mercapto acetaldehyde. This commercially available ambidentade compound is characterized as having in its chemical structure one group that acts as an electrophile and another that acts as a nucleophile, this permits its use as versatile and efficient synthon in synthetic heterocycle procedures. Objective: The aim of this review is to present synthetic applications of 1,4-DTD in heterocyclic chemistry and their applicability to the synthesis of bioactive compounds. Conclusion: Gewald reactions to obtain C-4 and C-5 unsubstitu

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2

S. Farhan, Mohammed, and Kawkab Y. Saour. "Synthesis of some Novel Nitrogenous Heterocyclic Compounds with Expected Biological Activity as Antimicrobial and Cytotoxic Agents." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 24, no. 1 (2017): 49–58. http://dx.doi.org/10.31351/vol24iss1pp49-58.

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This study includes synthesis of some nitrogenous heterocyclic compounds linked to amino acid esters or heterocyclic amines that may have a potential activity as antimicrobial and/or cytotoxic. Quinolines are an important group of organic compounds that possess useful biological activity as antibacterial, antifungal and antitumor .8-Hydroxyquinoline (8-HQ) and numerous of its derivatives exhibit potent activities against fungi and bacteria which make them good candidates for the treatment of many parasitic and microbial infection diseases. These pharmacological properties of quinolones a

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3

Bąchor, Urszula, та Marcin Mączyński. "Selected β2-, β3- and β2,3-Amino Acid Heterocyclic Derivatives and Their Biological Perspective". Molecules 26, № 2 (2021): 438. http://dx.doi.org/10.3390/molecules26020438.

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Heterocyclic moieties, especially five and six-membered rings containing nitrogen, oxygen or sulfur atoms, are broadly distributed in nature. Among them, synthetic and natural alike are pharmacologically active compounds and have always been at the forefront of attention due to their pharmacological properties. Heterocycles can be divided into different groups based on the presence of characteristic structural motifs. The presence of β-amino acid and heterocyclic core in one compound is very interesting; additionally, it very often plays a vital role in their biological activity. Usually, such

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4

Gudelis, Emilis, Sonata Krikštolaitytė, Monika Stančiauskaitė, et al. "Synthesis of New Azetidine and Oxetane Amino Acid Derivatives through Aza-Michael Addition of NH-Heterocycles with Methyl 2-(Azetidin- or Oxetan-3-Ylidene)Acetates." Molecules 28, no. 3 (2023): 1091. http://dx.doi.org/10.3390/molecules28031091.

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In this paper, a simple and efficient synthetic route for the preparation of new heterocyclic amino acid derivatives containing azetidine and oxetane rings was described. The starting (N-Boc-azetidin-3-ylidene)acetate was obtained from (N-Boc)azetidin-3-one by the DBU-catalysed Horner–Wadsworth–Emmons reaction, followed by aza-Michael addition with NH-heterocycles to yield the target functionalised 3-substituted 3-(acetoxymethyl)azetidines. Methyl 2-(oxetan-3-ylidene)acetate was obtained in a similar manner, which was further treated with various (N-Boc-cycloaminyl)amines to yield the target 3

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5

Padwa, A. "Application of cascade processes toward heterocyclic synthesis." Pure and Applied Chemistry 75, no. 1 (2003): 47–62. http://dx.doi.org/10.1351/pac200375010047.

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The reactions of N-acyliminium ions with tethered π-bonds are among the most important methods for preparing complex nitrogen-containing heterocycles. Pummerer-based cyclizations are also finding widespread application in both carbo- and heterocyclic syntheses. As part of a program concerned with new methods for alkaloid synthesis, we became interested in using a linked Pummerer/N-acyliminium ion cyclization sequence since we felt that this combination offers unique opportunities for the assemblage of complex target molecules. A synthetic method that combines transformations of different react

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6

Rusul Ali Muhammad and Rajaa A. A. Ghafil. "Synthesis, Identification some of new heterocyclic Compounds Derivatives and study of the biological Activity." Journal of Kufa for Chemical Sciences 3, no. 3 (2024): 336–51. https://doi.org/10.36329/jkcm/2024/v3.i3.15932.

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This research includes prepeared of some new heterocyclic compounds from 2-hydroxy napthaldehyde with 2-amino thiazol , 2-amino thiazol reacted with 2-hydroxy napthaldehyde , to produce shiff base derivative (R),(R) using to synthesis of some new heterocyclic derivatives by reactions and reactant with types solvent and materials to synthesis heterocyclic membered ring , first step : Involved synthesis of seven heterocyclic compounds by reacting (R) with phthalic ,succinic and malic anhydride respectfully to prepeared oxazepine compounds (R1,R2,R3) . Second step involves preparing of five- hete

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7

Polish, Nataliia, Nataliia Marintsova, Lesya Zhurakhivska, et al. "Antimicrobial Activity of Composite Preparations Based on Biosurfactants and Heterocyclic Amino-Containing 1,4-Naphtoquinone Derivativesantimicrobial Activity of Composite Preparations Based on Biosurfactants and Heterocyclic Amino-Containing 1,4-Naphtoquinone Derivatives." Innovative Biosystems and Bioengineering 8, no. 3 (2024): 18–28. http://dx.doi.org/10.20535/ibb.2024.8.3.311575.

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Background. The development of highly effective and environmentally safe composite drugs with antimicrobial properties is an important challenge in biotechnology and pharmacy. Objective. To determine the antimicrobial activity of new composite preparations based on rhamnolipids combined with heterocyclic amine-containing derivatives of 1,4-naphthoquinone against the test-bacteria Escherichia coli B-906, Staphylococcus aureus 209-P, Mycobacterium luteum B-917, and fungi Candida tenuis UCM Y-70 and Aspergillus niger UCM F-1119. Methods. The in vitro antimicrobial activity of heterocyclic amine-c

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8

Deng, Yongming, Qing-Qing Cheng, and Michael Doyle. "Asymmetric [3+3] Cycloaddition for Heterocycle Synthesis." Synlett 28, no. 14 (2017): 1695–706. http://dx.doi.org/10.1055/s-0036-1588453.

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Asymmetric syntheses of six-membered ring heterocycles are important research targets not only in synthetic organic chemistry but also in pharmaceuticals. The [3+3]-cycloaddition methodology is a complementary strategy to [4+2] cycloaddition for the synthesis of heterocyclic compounds. Recent progress in [3+3]-cycloaddition processes provide powerful asymmetric methodologies for the construction of six-membered ring heterocycles with one to three heteroatoms in the ring. In this account, synthetic efforts during the past five years toward the synthesis of enantioenriched six-membered ring hete

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9

Sasaki, Yu F. "How do Heterocyclic Amines, Amino Acid Pyrolysates, Inhibit DNA Repair." Advances in Clinical Toxicology 9, no. 1 (2024): 1–6. http://dx.doi.org/10.23880/act-16000300.

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Heterocyclic amines (HCAs) and β-carbolines, carcinogenic substances, are produced when amino acids and creatine in food react in a high-temperature environment. Some of them are reported to be rodent carcinogens and potent mutagens and to have co- clastogenic effects by inhibiting the incision step in DNA excision repair. In this study, we studied the mechanisms of their inhibition of DNA excision repair. HCAs (Trp-P- 1, IQ, and Me IQ) suppressed comet responses by UV. Since they were antagonistic to novobiocin that is an inhibitor of ATPase subunit of topoisomerase acting the in the incision

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10

Ashok, S. R., and M. K. Shivananda. "Synthesis and Characterization and Antifungal Screening Studies of Some Novel Imidazole Derivatives." 1 8, no. 1 (2022): 39–43. http://dx.doi.org/10.46632/jemm/8/1/7.

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Imidazole derivatives are five-mamboed heterocyclic having nitrogen, and oxygen atoms in their ring structure and exhibiting potent as well as wide range of pharmacological activities. Current investigations of imidazole derivatives have provided information that these derivatives may have applications in antimicrobial, antifungal, antiviral, as well as antidiabitic treatments. Fen bam is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular target in the brain. The imidazole ring system is present in im

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11

Abbasi, Muhammad, Muhammad Ramzan, A. Aziz-Ur-Rehman, et al. "Structure-activity relationship and in silico study of unique bi-heterocycles: 5-[(2-amino-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazole-2-thiol derivatives." Journal of the Serbian Chemical Society 84, no. 7 (2019): 649–61. http://dx.doi.org/10.2298/jsc180203019a.

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This paper presents the synthesis of some unique bi-heterocyclic hybrid molecules with a thiazole and an oxadiazole ring. The synthesis was initiated by the conversion of ethyl 2-(2-amino-1,3-thiazol-4-yl)acetate (1) to the corresponding 2-(2-amino-1,3-thiazol-4-yl)acetohydrazide (2) by the reaction with hydrazine hydrate in methanol. The treatment of the acid hydrazide, 2, with carbon disulfide gave the bi-heterocyclic nucleophile, 5-[(2-amino-1,3- -thiazol-4-yl)methyl]-1,3,4-oxadiazole-2-thiol (3). Finally, the target compounds, 5a?o, were synthesized by stirring the nucleophile 3 with diffe

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12

Rajendran, Rajam, and Yoshiyuki Ohta. "Binding activity of Natto (a fermented food) and Bacillus natto isolates to mutagenic-carcinogenic heterocyclic amines." Canadian Journal of Microbiology 47, no. 10 (2001): 935–42. http://dx.doi.org/10.1139/w01-094.

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The fermented food, whole meal Natto, viscous polymeric material from Natto, Natto bean, cooked soya bean, and 28 bacterial isolates from Natto were studied for their binding capacity to foodborne mutagenic-carcinogenic heterocyclic amines. The mutagenic heterocyclic amines used were Trp-P-1 (3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole); Trp-P-2 (3-amino-1-methyl-5H-pyrido(4,3-b)indole); Glu-P-1 (2-amino-6-methyldipyrido(1,2-a:3'2'-d)imidazole); PhIP (2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine); IQ (2-amino-3-methylimidazo(4,5-f)quinoline); MeIQ (2-amino-3,4-dimethylimidazo(4,5-f)quinoxal

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13

Lynch, Daniel E., Laura J. Nicholls, Graham Smith, Karl A. Byriel, and Colin H. L. Kennard. "Molecular co-crystals of 2-aminothiazole derivatives." Acta Crystallographica Section B Structural Science 55, no. 5 (1999): 758–66. http://dx.doi.org/10.1107/s0108768199003146.

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A series of molecular adducts of 2-aminothiazole derivatives – 2-aminothiazole, 2-amino-2-thiazoline and 2-aminobenzothiazole with the carboxylic-acid-substituted heterocyclics indole-2-carboxylic acid, N-methylpyrrole-2-carboxylic acid and thiophene-2-carboxylic acid – have been prepared and characterized using X-ray powder diffraction and in five cases by single-crystal X-ray diffraction methods. These five compounds are the adducts of 2-amino-2-thiazolium with indole-2-carboxylate [(C3H7N2S)+(C9H6NO2)−], and N-methylpyrrole-2-carboxylate [(C3H7N2S)+-(C6H6NO2)−], 2-aminobenzothiazolium with

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14

Padwa, A. "Tandem methodology for heterocyclic synthesis." Pure and Applied Chemistry 76, no. 11 (2004): 1933–52. http://dx.doi.org/10.1351/pac200476111933.

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Tandem methodology for heterocyclic synthesis represents a powerful approach for the rapid buildup of molecular complexity from potentially simple starting materials. Work from our laboratory has shown that the rhodium(II)-catalyzed cyclization cascade of alpha-diazo imides represents an effective method for the synthesis of a variety of heterocyclic systems. As an extension of these studies, we became interested in using a linked Pummerer/N-acyliminium ion cyclization sequence since we felt that this combination offers unique opportunities for the assemblage of complex target molecules. A syn

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15

Khusenov, K. Sh, B. B. Umarov, K. K. Turgunov, O. Zh Bakhranova, T. B. Aliev, and B. T. Ibragimov. "Zinc(II) complexes with thiadiazole derivatives-1,3,4." Журнал неорганической химии 69, no. 2 (2024): 193–202. http://dx.doi.org/10.31857/s0044457x24020061.

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Zn(II) complexes of the composition [ZnLn2X2] and [ZnLn3(NO3)2] were synthesized, where n = 1, 2; X=Cl, Br, I; L1=2-aminothiadiazole-1,3,4, L2=2-amino-5-methylthiadiazole-1,3,4. The obtained complexes were studied by elemental analysis methods, IR and 1H NMR spectroscopy. The structure of the [ZnL22Br2] complex was determined by the RSA method (CIF file CCDC No. 2251742). The ligand molecules of 2-amino-5-R-thiadiazoles-1,3,4 (R = –H, –CH3) are coordinated monodentately by an endocyclic nitrogen atom located in the α-position to the amino group. The polyhedron of the central atom of halide com

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16

Feng, Si Min, and Qing Liu. "Research Progress of N-Alkylation of Alcohol and Amine by "Hydrogen Reaction"." Key Engineering Materials 871 (January 2021): 312–17. http://dx.doi.org/10.4028/www.scientific.net/kem.871.312.

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Amine compounds are widely found in natural products, pharmaceuticals and fine chemical products. Therefore, it is of great significance to develop methods for synthesizing amine compounds. Therefore, in recent years, a new method of synthesizing amines has been developed, namely "hydrogen borrowing reaction". This article reviews the alkylation of primary alcohols and amines, the cyclization of amino alcohols to form N-heterocyclic compounds, the reaction of diols and amines to form N-heterocyclic compounds, the reaction of alcohols and sulfonamides, and the reaction of alcohols and amines co

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17

D’yachenko, E., T. Glukhareva, L. Dyudya, O. Eltsov, and Y. Morzherin. "The tert-Amino Effect in Heterocyclic Chemistry. Synthesis of Spiro Heterocycles." Molecules 10, no. 9 (2005): 1101–8. http://dx.doi.org/10.3390/10091101.

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18

Negi, Arvind, and Ali R. Tehrani-Bagha. "Cellulose Functionalization Using N-Heterocyclic-Based Leaving Group Chemistry." Polymers 16, no. 1 (2024): 149. http://dx.doi.org/10.3390/polym16010149.

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There has been continuous interest in developing novel activators that facilitate the functionalization of cellulosic materials. In this paper, we developed a strategy in which trisubstituted triazinium salts act as cellulose preactivators. As leaving groups, these triazinium salts utilize N-heterocycles (pyridine, imidazole, and nicotinic acid). Initially, we optimized the synthetic route for developing these novel cellulose preactivators (triazinium salts), whose structures were confirmed using NMR spectroscopy. The surface zeta potential of cellulose changed from a negative value to a posit

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19

Lynch, Daniel E., and Glyn D. Jones. "Geometry of the 2-aminoheterocyclic–carboxylic acid R 2 2(8) graph set: implications for crystal engineering." Acta Crystallographica Section B Structural Science 60, no. 6 (2004): 748–54. http://dx.doi.org/10.1107/s0108768104023791.

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The geometry of the R_2^2(8) graph set formed between a 2-aminoheterocyclic ring containing an Nsp 2 atom (in the 1-position of the ring) and a carboxylic acid has been studied. Collating data from known co-crystal structures containing five- and six-membered heterocyclic rings from the Cambridge Structural Database revealed unexpected differences between two kinds of non-hydrogen contact distances, and between specific bond distances and angles of the heterocycle. Not only were the interatomic non-hydrogen distances between the N atoms (heterocycle) and O atoms (carboxylate) asymmetric, but a

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20

Rajendran, Rajam, and Yoshiyuki Ohta. "Binding of heterocyclic amines by lactic acid bacteria from miso, a fermented Japanese food." Canadian Journal of Microbiology 44, no. 2 (1998): 109–15. http://dx.doi.org/10.1139/w97-133.

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Miso, a widely used Japanese fermented food was analysed for its lactic acid bacterial count on bromocresol purple agar. The binding of eight different foodborne carcinogenic heterocyclic amines to 25 bacterial isolates from miso were investigated. The heterocyclic amines used were 3-amino-1,4-dimethyl[5H]pyrido(4,3-b)indole (Trp-P-1), 3-amino-1-methyl[5H]pyrido(4,3-b)indole (Trp-P-2), 2-amino-6-methyldipyrido(1,2-a:3'2'-d)imidazole (Glu-P-1), 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), 2-amino-dimethylimidazo(4,5f)quinoline (IQ), 2-amino-3,4-dimethylimidazo(4,5-f) quinoline (MeIQ)

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21

Sharma, Ankita, Arindam Gupta, Naureen Khan, and Anita DuttKonar. "Can non-heterocyclic hydrophobic amino acids when tethered at the C-terminus of 12-hydroxy stearic acid-based amphiphilic derivatives drive hydrogelation propensity effectively?" New Journal of Chemistry 44, no. 22 (2020): 9213–22. http://dx.doi.org/10.1039/d0nj01583k.

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The amphiphilic derivatives comprising of non-heterocyclic, hydrophobic amino acids at the C-terminal end, not only displayed excellent gelation ability but also high mechanical integrity in comparison to the heterocyclic analogues.

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22

Danopoulos, Andreas A., Pierre Braunstein, Elixabete Rezabal, and Gilles Frison. "Unprecedented directed lateral lithiations of tertiary carbons on NHC platforms." Chemical Communications 51, no. 15 (2015): 3049–52. http://dx.doi.org/10.1039/c4cc08434a.

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Deprotonation of the tautomeric mixture of 4-amido-imidazoliums and 4-amino-N-heterocyclic carbenes led to dilithiated dianionic functional NHCs, via an unprecedented regioselective, directed remote lateral lithiation of a tertiary CHMe<sub>2</sub> carbon. DFT calculations support that the nature of products is under thermodynamic control.

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23

Tang, Jinghua, Xuejiao J. Gao, Huarong Tang, and Xiaoming Zeng. "Dioxygen activation with stable N-heterocyclic carbenes." Chemical Communications 55, no. 11 (2019): 1584–87. http://dx.doi.org/10.1039/c8cc08911f.

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24

Lelyukh, Maryan I., Ivan O. Krukovskiy, Zoryana M. Komarenska, Nataliia V. Yelahina, Taras I. Chaban, and Ihor G. Chaban. "Appliance Features of 4-Amino-1,2,4-triazole-3-thiols in the Synthesis of 3,6-Disubstituted [1,2,4]Triazolo[3,4-b] [1,3,4]thiadiazoles." Acta Chimica Slovenica 72, no. 2 (2025): 238–59. https://doi.org/10.17344/acsi.2025.9169.

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4-Amino-5-substituted-4H-1,2,4-triazole-3-thiols are versatile synthons for the construction of various biologically active heterocycles. This is provided by the close proximity of the amino and mercapto groups, which serve as readily accessible nucleophilic centers for the preparation of N-bridged heterosystems. One of the possible and convenient directions of using 4-amino-4H-1,2,4-triazole-3-thiols in heterocyclic synthesis is based on their utilization in reaction with various carboxylic acids in the presence of dehydrating reagents, most often phosphorus oxychloride. Synthesized as follow

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25

Velihina, Yevheniia, Nataliya Obernikhina, Stepan Pilyo, Maryna Kachaeva, and Oleksiy Kachkovsky. "In silico study the interaction of heterocyclic bases with peptide moieties of proteins in the "fragment-to-fragment" approach." Ukr. Bioorg. Acta 2021, Vol. 16, N1 16, no. 1 (2021): 34–43. http://dx.doi.org/10.15407/10.15407/bioorganica2021.01.034.

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The binding affinity of model peptide moieties (Pept) and heterocyclic bases involving 1,3-oxazoles that are condensed with pyridine and pyrimidine as pharmacophores (Pharm) was investigated in silico and analyzed within the «fragment-to-fragment» approach. The anellation of the heterocyclic rings increasing their acceptor properties is accompanied by gaining stability of the [Pharm-Pept] complexes formed by the π,π-stacking interaction. It was found that elongation of the polypeptide chain led to a twofold increase of the stabilization energy of the [Pharm-Pept] complexes. The stability of th

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26

Velihina, Yevheniia S., Nataliya V. Obernikhina, Stepan G. Pilyo, Maryna V. Kachaeva, and Oleksiy D. Kachkovsky. "In silico study the interaction of heterocyclic bases with peptide moieties of proteins in “fragment-to-fragment” approach." Ukrainica Bioorganica Acta 16, no. 1 (2021): 34–43. http://dx.doi.org/10.15407/bioorganica2021.01.034.

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The binding affinity of model peptide moieties (Pept) and heterocyclic bases involving 1,3-oxazoles that are condensed with pyridine and pyrimidine as pharmacophores (Pharm) was investigated in silico and analyzed within the “fragment-to-fragment” approach. The anellation of the heterocyclic rings increasing their acceptor properties is accompanied by gaining stability of the [Pharm-Pept] complexes formed by the p-stack interaction. It was found that elongation of the polypeptide chain led to a twofold increase of the stabilization energy of the [Pharm-Pept] complexes. The stability of the hyd

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27

Abdel Hafez, Ali A., Ibrahim M. A. Awad, and Raga A. Ahmed. "New Heterocyclo-Substituted Pyrazolo[3,4-b]pyridine Derivatives." Collection of Czechoslovak Chemical Communications 58, no. 5 (1993): 1198–202. http://dx.doi.org/10.1135/cccc19931198.

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In this investigation and in continuance with our previous work in the synthesis of some heterocyclic compounds fused with pyridine moiety, we used 3-amino-4,6-diphenyl-1H-pyrazolo[3,4-b]pyridine (II) as starting material to synthesize many heterocyclic compounds containing pyrazolopyridine moiety.

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28

Kederienė, Vilija, Indrė Jaglinskaitė, Paulina Voznikaitė, et al. "Mild Copper-Catalyzed, l-Proline-Promoted Cross-Coupling of Methyl 3-Amino-1-benzothiophene-2-carboxylate." Molecules 26, no. 22 (2021): 6822. http://dx.doi.org/10.3390/molecules26226822.

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Cu-catalyzed N-arylation is a useful tool for the chemical modification of aromatic heterocycles. Herein, an efficient carbon–nitrogen cross-coupling of methyl 3-amino-1-benzothiophene-2-carboxylate with a range of (hetero)aryl iodides using CuI, l-proline and Cs2CO3 in dioxane at moderate temperature is described. The procedure is an extremely general, relatively cheap, and experimentally simple way to afford the N-substituted products in moderate to high yields. The structures of the new heterocyclic compounds were confirmed by NMR spectroscopy and HRMS investigation.

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Hamdi, Maamar, Oualid Talhi, Artur Silva, et al. "Synthetic Approach Toward Heterocyclic Hybrids of [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazines." Synlett 29, no. 11 (2018): 1502–4. http://dx.doi.org/10.1055/s-0036-1591991.

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The synthesis of novel heterocyclic [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine hybrids by a bimolecular reaction of 2-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-yl)phenol with an aromatic or heterocyclic α-bromoacetyl derivatives is described. This synthetic procedure starts from an unprotected phenol.

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30

Quiroga, Diego, and Ericsson Coy-Barrera. "Synthesis of Antifungal Heterocycle-Containing Mannich Bases: A Comprehensive Review." Organics 4, no. 4 (2023): 503–23. http://dx.doi.org/10.3390/org4040035.

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Mannich bases are a class of organic compounds usually obtained by the condensation reaction between an amine, a compound with active hydrogens, and an aldehyde. They are versatile intermediates in organic synthesis, and those compounds containing this motif find applications in pharmaceutical, agrochemical, and even material fields since they are widely known for their wide range of biological activities, including antimicrobial properties. Thus, as part of our interest in antifungal agents, this narrative review aimed to gather information from the literature on the synthesis of various repr

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Mseer, Marwa Abdulameer, Khudheyer Jawad, and Yahya Al-Khafaji. "Synthesis and Characterization of Heterocyclic Compounds Derived from Schiff base Glycerol Triester." NeuroQuantology 19, no. 9 (2021): 88–96. http://dx.doi.org/10.14704/nq.2021.19.9.nq21141.

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Heterocyclic compounds were prepared from Schiff bases triester derivatives, the first step was included, p- aminobenzoic acids convert to p-amino benzoyl chloride in the presence of thionyl chloride then glycerol was added to form triesters compound A. second step reaction of triester product with the 4-nitrobenzaldehyde, and 3-amino benzaldehyde to produce M1, and M2. The third step. Involve reacted Schiff bases triester derivatives to give heterocyclic compounds M1S, M1A, M2P, and M2K. The structure of all compounds is monitored by (TLC), and identified by many techniques 1HNMR, FT-IR, and

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Deeb, Ali, Medhat El-Mobayed, Abdel Naby Essawy, Adel Abd El-Hamid, and Atef Mohamid Abd El-Hamid. "Heterocyclic synthesis from 3-amino-4-cyanopyrazole." Collection of Czechoslovak Chemical Communications 55, no. 3 (1990): 728–33. http://dx.doi.org/10.1135/cccc19900728.

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3-Amino-4-cyanopyrazole I reacts with hydroxylamine and with hydrazine to yield 1H,6H-3-aminopyrazolo[3,4-c]pyrazole (III and IV). Diazotized IV couples with 2-naphthol to give the arylazo derivative VI which cyclizes to 9H-naphthol[2,1-e]pyrazolo[3',4':3,4]pyrazolo[5,1-c]-[1,2,4]triazine VII by means of acetic acid. The pyrazol-5-ylthiourea obtained from I and phenyl isothiocyanate undergoes base-catalyzed cyclization to give pyrazolo[3,4-d]pyrimidinethione derivative IX. Compound I reacts with cyclohexane in the presence of zinc chloride to give the tetrahydropyrazolo[3,4-b]quinoline derivat

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33

Ledoux, Stéphane, Jean-Pierre Célérier та Gérard Lhommet. "Diastereospecific alkylation of heterocyclic β-amino esters". Tetrahedron Letters 40, № 51 (1999): 9019–20. http://dx.doi.org/10.1016/s0040-4039(99)01917-6.

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34

F�ld�nyi, R., G. Szalontai, N. Szeb�nyi, P. Kvintovics, and T. Bartik. "Heterocyclic derivatives of 2-amino-4-nitrophenol." Monatshefte f�r Chemie Chemical Monthly 127, no. 3 (1996): 305–11. http://dx.doi.org/10.1007/bf00813796.

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35

Eliseeva, Tatiana, and Anastasiia Kharina. "Current-Voltage and Transport Characteristics of Heterogeneous Ion-Exchange Membranes in Electrodialysis of Solutions Containing a Heterocyclic Amino Acid and a Strong Electrolyte." Membranes 13, no. 1 (2023): 98. http://dx.doi.org/10.3390/membranes13010098.

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The alterations in current-voltage and transport characteristics of highly basic and strongly acidic ion-exchange membranes, during the electrodialysis of solutions containing a heterocyclic amino acid and a strong electrolyte, were studied. An increase in the catalytic activity of the water splitting process at the surface of heterogeneous MK-40 and MA-41 membranes upon prolonged contact with proline and tryptophan solutions was found. A significant effect of electroconvection on the components mass transfer through the cation-exchange membrane in the intensive current mode of electrodialysis

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36

Möhrle, H., and D. Schake. "Heterocyclische Spirocyclohexadienone aus substituierten Phenolen / Heterocyclic Spirocyclohexadienones from Substituted Phenols." Zeitschrift für Naturforschung B 50, no. 12 (1995): 1859–68. http://dx.doi.org/10.1515/znb-1995-1213.

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Mannich bases were prepared from substituted phenols with aliphatic amines and formaldehyde. Amine exchange with N-methyl-2-naphthylamine followed by a Hofmann Martius rearrangement gave rise to o,o′-amino-hydroxy-diphenylmethane derivatives. Under cyclization conditions some of these compounds produced spirocyclohexadienones, which are the ipso analogs to the hypothetic intermediates postulated in the aminomethylation mechanism of phenols.

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37

Kaur Bhatia, Richa. "Anti-Protozoal Potential of Heterocyclic Compounds Against Giardiasis." Current Bioactive Compounds 15, no. 3 (2019): 280–88. http://dx.doi.org/10.2174/1573407214666180201154009.

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The aim of this literature review is to compile data of heterocyclic antigiardial agents. The importance is to analyze the structural requirements for improved antigiardial activity, to overcome resistance and enhance the bioavailability of the compounds under study. Though, nitroimidazoles/ imidazoles and benzimidazoles are major classes, other heterocyclic scaffolds viz. oxoindolinylidene, dioxodihydroisobenzofuran-5-carboxamide, fluoroquinolone, thieno[2,3-b]pyridine- 5-carbonitrile, &#945;-amino-phosphonate analogs of polyoxins, nitazoxanide benzologue, thiazole and triazolyl- quinolon

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38

Hafez, Hend N., and Abdel-Rahman B. A. El-Gazzar. "Synthesis of Novel Pyridine Bearing Biologically Active Imidiazolyl, Pyrazolyl, Oxa/thiadiazolyl and Urea Derivatives as Promising Anticancer Agents." Current Organic Synthesis 17, no. 1 (2020): 55–64. http://dx.doi.org/10.2174/1570179417666191223163225.

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Background: A novel series of pyridine containing 1,3,4-oxa/thiadiazol derivatives 4a,b, pyrazole derivatives 5-7, thiazole derivatives 9a,b and 17a-c, urea derivatives 12a-c, imidiazole derivative 16, imidazo[1,2-a]pyridine derivatives 18a, b, tetrazole 19, pyrane 20 and pyridine derivatives 21 has been synthesized. Objective: This research aims to synthesize 6-(Trifluoromethyl)-2-[3-(trifluoromethyl)phenyl] amino nicotinohydrazide 2 and 6-(trifluoromethyl)-2-[3-(trifluoromethyl)phenyl]amino pyridin-3-carboaldhyde 15 as key intermediate for the synthesis of novel pyridine derivatives bearing

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39

Nikiforov, L. A., M. V. Belousov, and N. S. Fursa. "Study of amino-acid structure Lemna minor L." Bulletin of Siberian Medicine 10, no. 5 (2011): 74–77. http://dx.doi.org/10.20538/1682-0363-2011-5-74-77.

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For the first time qualitative and quantitative amino-acid structure Lemna minor L. is studied with use of a highly effective liquid chromatography. Presence 18 proteinogennic amino acids, including 8 irreplaceable is established. The sum of replaceable amino acids of a duckweed small is presented monoaminocarboxylic,monoaminodicarboxylic, diaminomonocarboxylic and heterocyclic acids. Irreplaceable amino acids are presented monoaminomonocarboxylic and diaminomonocarboxylic by acids.

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Ebrahimi, Behzad, and Maryam Farshidi. "Innovative Approaches for the Degradation of Biogenic Amines in Foods." Current Nutrition & Food Science 15, no. 6 (2019): 627–28. http://dx.doi.org/10.2174/1573401314666180620161417.

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Biogenic Amines (BA) are low molecular weight organic bases that have biological activity, they can be formed and degraded as a result of normal metabolic activity in animals, plants and microorganisms, and are usually produced by the decarboxylation of amino acids. The most common biogenic amines which can be found in foods are aliphatic (putrescine, cadaverine, spermine, spermidine), aromatic (tyramine, phenylethyl amine) or heterocyclic (histamine, tryptamine) structures.

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41

Journal, Baghdad Science. "Synthesis and Characterization of New Polyimide Contain Heterocyclic." Baghdad Science Journal 10, no. 4 (2013): 1203–10. http://dx.doi.org/10.21123/bsj.10.4.1203-1210.

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Novel heterocyclic polyimide 5(a,b) have been synthesized based on polyacrylic backbone. The synthetic route start with nucleophilic substitution of 2-amino, or 4-amino, pyridine 1(a,b) to the polyacryloyl chloride afforded poly substituted amide 2(a,b). Another nucleophilic substitution were carried with adipoyl chloride to form polyimide chloride 3(a,b). Treatment of 3(a,b) with hydrazine hydrate afforded acid hydrazide polyimide 4(a,b), which upon cyclocondensation with carbon disulfide gave the target heterocyclic polyimide. The synthesized compounds were identified by spectroscopic method

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42

Al-Tamimi, Entesar O., and Thanaa M. Al-Mouamin. "Synthesis and Characterization of New Polyimide Contain Heterocyclic." Baghdad Science Journal 10, no. 4 (2013): 1203–10. http://dx.doi.org/10.21123/bsj.2013.10.4.1203-1210.

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Novel heterocyclic polyimide 5(a,b) have been synthesized based on polyacrylic backbone. The synthetic route start with nucleophilic substitution of 2-amino, or 4-amino, pyridine 1(a,b) to the polyacryloyl chloride afforded poly substituted amide 2(a,b). Another nucleophilic substitution were carried with adipoyl chloride to form polyimide chloride 3(a,b). Treatment of 3(a,b) with hydrazine hydrate afforded acid hydrazide polyimide 4(a,b), which upon cyclocondensation with carbon disulfide gave the target heterocyclic polyimide. The synthesized compounds were identified by spectroscopic method

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43

Cudero, José, Carmen Pardo, Mar Ramos, Enrique Gutierrez-Puebla, Angeles Monge, and José Elguero. "Synthesis and molecular structure of heterocyclic Tröger's bases derived from C-amino heterocycles." Tetrahedron 53, no. 6 (1997): 2233–40. http://dx.doi.org/10.1016/s0040-4020(96)01125-8.

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Journal, Baghdad Science. "Synthesis and Characterization of Five, Sevene Heterocyclic Membered Rings." Baghdad Science Journal 10, no. 3 (2013): 803–17. http://dx.doi.org/10.21123/bsj.10.3.803-817.

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New compounds containing heterocyclic units have been synthesized. These compounds include 2-amino 5- phenyl-1,3,4-thiadiazole (1) as starting material to prepare the Schiff bases 2N[3-nitrobenzylidene -2 hydroxy benzylidene and 4-N,N-dimethyl aminobenzylidene] -5-phenyl-1,3,4-thiadiazole (2abc) , 2N[3-nitrophenyl, 2-hydroxyphenyl or 4-N,N-dimethylaminophenyl] 3-]2-amino-5-phenyl-1,3,4-thiadiazole]-2,3-dihydro-[1,3]oxazepine-benzo-4,7-dione] (3abc), 2N[3-nitrophenyl,2-hydroxyphenyl,4-N,N-dimethylaminophenyl]-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine-4,7-dione[(4abc

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45

Mahmoud, Muhaned J., Ibtisam K. Jassim, and Muhanned A. Mahmoud. "Synthesis and Characterization of Five, Sevene Heterocyclic Membered Rings." Baghdad Science Journal 10, no. 3 (2013): 803–17. http://dx.doi.org/10.21123/bsj.2013.10.3.803-817.

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New compounds containing heterocyclic units have been synthesized. These compounds include 2-amino 5- phenyl-1,3,4-thiadiazole (1) as starting material to prepare the Schiff bases 2N[3-nitrobenzylidene -2 hydroxy benzylidene and 4-N,N-dimethyl aminobenzylidene] -5-phenyl-1,3,4-thiadiazole (2abc) , 2N[3-nitrophenyl, 2-hydroxyphenyl or 4-N,N-dimethylaminophenyl] 3-]2-amino-5-phenyl-1,3,4-thiadiazole]-2,3-dihydro-[1,3]oxazepine-benzo-4,7-dione] (3abc), 2N[3-nitrophenyl,2-hydroxyphenyl,4-N,N-dimethylaminophenyl]-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine-4,7-dione[(4abc

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46

Tafelska-Kaczmarek, Agnieszka, Marcin Kwit та Bartosz Stasiak. "Highly Asymmetric Reduction of New Benzofuryl and Benzothiophenyl α-Amino Ketones". Proceedings 41, № 1 (2019): 49. http://dx.doi.org/10.3390/ecsoc-23-06506.

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Heterocyclic compounds play an important role in medicinal chemistry and occupy a central position in synthetic organic chemistry. Both benzofuran and benzothiophene are considered as very important structures due to their diverse biological and pharmacological profile. Many clinically approved drugs are synthetic and naturally occurring substituted benzofuryl and benzothiophenyl derivatives in conjunction with other heterocycles. Therefore, a new series of α-amino ketone (containing various azole rings) derivatives of benzofuran and benzothiophene are synthesized and subjected to the transfer

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47

Ziarani, Ghodsi Mohammadi, Marzieh Rad, Fatemeh Mohajer, Hitesh Sehrawat, and Ravi Tomar. "Synthesis of Heterocyclic Compounds through Multicomponent Reactions Using 6-Aminouracil as Starting Reagent." Current Organic Chemistry 25, no. 9 (2021): 1070–95. http://dx.doi.org/10.2174/1385272825666210303112858.

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The analogs of 6-Amino uracil are essential components due to their biological activities. The uracil is used as an important component for the synthesis of heterocyclic compounds like pyrrolo-, pyrido-, pyrimidine-pyrimido scaffolds. Herein, the application of this compound is reviewed as a precursor in the synthesis of many heterocyclic cores from 2016 to 2020.

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48

Makhloufi, Abdelaziz, Walter Frank, and Christian Ganter. "Diamino- and Mixed Amino–Amido-N-Heterocyclic Carbenes Based on Triazine Backbones." Organometallics 31, no. 5 (2012): 2001–8. http://dx.doi.org/10.1021/om201275z.

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49

Makhloufi, Abdelaziz, Michaela Wahl, Walter Frank, and Christian Ganter. "A New Mixed Amino–Amido N-Heterocyclic Carbene Based on Anthranilic Acid." Organometallics 32, no. 3 (2013): 854–61. http://dx.doi.org/10.1021/om301152n.

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50

Velíšek, J., and K. Cejpek. "Biosynthesis of food constituents: Amino acids: 2. The alanine-valine-leucine, serine-cysteine-glycine, and aromatic and heterocyclic amino acids groups – a review." Czech Journal of Food Sciences 24, No. 2 (2011): 45–58. http://dx.doi.org/10.17221/3299-cjfs.

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This review article gives a survey of principal pathways that lead to the biosynthesis of the proteinogenic amino acids of the alanine-valine-leucine group starting with pyruvic acid from the glycolytic pathway and serine-cysteine-glycine group starting with 3-phospho-d-glyceric acid from the glycolytic pathway. A survey is further given to the aromatic and heterocyclic amino acids (phenylalanine, tyrosine, tryptophan, histidine) starting with 3-phosphoenolpyruvic acid from the glycolytic pathway and d-erythrose 4-phosphate, an intermediate in the pentose phosphate cycle and Calvin cycle. &amp

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