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Relevant bibliographies by topics / Heterocyclic chemistry; Cancer

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Academic literature on the topic 'Heterocyclic chemistry; Cancer'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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Journal articles on the topic "Heterocyclic chemistry; Cancer"

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Mir, Reyaz Hassan, Roohi Mohi-ud-din, Taha Umair Wani, Mohammad Ovais Dar, Abdul Jaleel Shah, Bashir Lone, Chawla Pooja, and Mubashir Hussain Masoodi. "Indole: A Privileged Heterocyclic Moiety in the Management of Cancer." Current Organic Chemistry 25, no. 6 (March 26, 2021): 724–36. http://dx.doi.org/10.2174/1385272825666210208142108.

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Heterocyclic are a class of compounds that are intricately entwined into life processes. Almost more than 90% of marketed drugs carry heterocycles. Synthetic chemistry, in turn, allocates a cornucopia of heterocycles. Among the heterocycles, indole, a bicyclic structure consisting of a six-membered benzene ring fused to a five-membered pyrrole ring with numerous pharmacophores that generate a library of various lead molecules. Due to its profound pharmacological profile, indole got wider attention around the globe to explore it fully in the interest of mankind. The current review covers recent advancements on indole in the design of various anti-cancer agents acting by targeting various enzymes or receptors, including (HDACs), sirtuins, PIM kinases, DNA topoisomerases, and σ receptors.

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Georghiou, Paris E. "Preface." Pure and Applied Chemistry 82, no. 9 (January 1, 2010): iv. http://dx.doi.org/10.1351/pac20108209iv.

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The 22nd International Congress on Heterocyclic Chemistry (ICHC-22) was held 2-7 August 2009 in St. John's, Newfoundland and Labrador, Canada. St. John's, the capital of Canada's youngest Province, Newfoundland and Labrador, is also Canada’s oldest and North America’s most easterly city. The Conference was chaired by Prof. Mohsen Daneshtalab (School of Pharmacy, Memorial University of Newfoundland) and was organized by the School of Pharmacy and the Chemistry Department at Memorial University of Newfoundland.Approximately 260 participants from over 30 different countries attended. The scientific program consisted of 10 plenary lectures, 19 invited lectures, 52 short communications, and 115 posters. Prof. Samuel Danishefsky (Sloan-Kettering Institute for Cancer Research, Columbia University) was honored with the 2009 ISHC Senior Award in Heterocyclic Chemistry, and Prof. John Wood (Colorado State University) was the 2009 Katritzky Junior Award winner. A special symposium entitled "Focus on heterocycles in organic synthesis today and tomorrow" was held during the Congress as a tribute to Prof. Victor Snieckus (Queen's University, Kingston) for his research accomplishments and long-time contribution to the International Society of Heterocyclic Chemistry (ISHC).The five Congress themes were:- New Methods in Heterocyclic Chemistry- Biologically Active Heterocycles (Pharmaceuticals/Agrochemicals)- Heterocyclic Natural Products and their Analogues- Applications of Heterocycles in Organic Synthesis- Heterocycles in Materials ScienceBesides the collection of 9 papers that are based on the plenary and invited lectures included in this issue of Pure and Applied Chemistry, the ICHC-22 Book of Abstracts is available online and can be downloaded for free from http://www.ichc2009.ca/abstract_book.pdf in pdf format.ICHC-23 will be held in Glasgow, Scotland, 31 July to 5 August 2011 with the following five main themes of heterocyclic chemistry: synthetic methodology, natural products and complex molecule synthesis, materials, medicinal chemistry, and nanochemistry. The conference will be chaired by Prof. Colin Suckling (University of Strathclyde).The organizers are grateful to all who contributed to a successful scientific program, especially to the speakers and to our public and private sponsors: City of St. John's, Memorial University of Newfoundland, IUPAC, Thieme, Wiley-Blackwell, Elsevier, Taiho Pharmaceutical Co., ChemRoutres Corporation, and American Diagnostica, Inc.Paris E. GeorghiouConference Editor

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Grover, Parul, Monika Bhardwaj, Garima Kapoor, Lovekesh Mehta, Roma Ghai, and K. Nagarajan. "Advances on Quinazoline Based Congeners for Anticancer Potential." Current Organic Chemistry 25, no. 6 (March 26, 2021): 695–723. http://dx.doi.org/10.2174/1385272825666210212121056.

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The heterocyclic compounds have a great significance in medicinal chemistry because they have extensive biological activities. Cancer is globally the leading cause of death and it is a challenge to develop appropriate treatment for the management of cancer. Continuous efforts are being made to find a suitable medicinal agent for cancer therapy. Nitrogencontaining heterocycles have received noteworthy attention due to their wide and distinctive pharmacological activities. One of the most important nitrogen-containing heterocycles in medicinal chemistry is ‘quinazoline’ that possesses a wide spectrum of biological properties. This scaffold is an important pharmacophore and is considered a privileged structure. Various substituted quinazolines displayed anticancer activity against different types of cancer. This review highlights the recent advances in quinazoline based molecules as anticancer agents. Several in-vitro and in-vivo models used along with the results are also included. A subpart briefing natural quinazoline containing anticancer compounds is also incorporated in the review.

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Foldesi, Tamas, Balazs Volk, and Matyas Milen. "A Review of 2,3-Benzodiazepine-related Compounds: Diazepines and 1,2,5- Triazepines Fused with Five-membered Nitrogen Heterocycles." Current Organic Synthesis 15, no. 6 (August 29, 2018): 729–54. http://dx.doi.org/10.2174/1570179415666180601101856.

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Background: 2,3-Benzodiazepines represent an important class of biologically active compounds, some members of this family have reached the human clinical stage. With formal bioisosteric replacement of the benzene ring to five-membered nitrogen heterocycles, several new diazepine and 1,2,5-triazepine derivatives have been synthesized in the past 30 years. Objective: Investigations in the field of heterocyclic chemistry is very important, because there could be several new medicines among the newly synthesized heterocyclic ring systems, which could be used against several diseases which have no remedy yet, for example some types of cancer. The research on antibacterial compounds is also an important field because of spreading of multiresistant pathogens. This review aims to summarize the literature of certain 2,3-benzodiazepine analogues. Conclusion: After a brief historical introduction, various ring systems containing a 2,3-diazepine or a 1,2,5- triazepine ring condensed with five-membered nitrogen heterocycles are disclosed. First, pyrrole-fused compounds are introduced, followed by indole and carbazole derivatives. After that, diverse ring systems containing an imidazole ring are presented. The review is closed with the chemistry of some interesting triazole and tetrazole derivatives. Many of these compounds bear significant biological efficacy.

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Harith M. Al-ajely. "Synthesis and pharmaceutical applications of Oxazine compounds derived from Pyronic, Salicylic, Antharanilic acids and Phenols." International Journal of Science and Research Archive 2, no. 2 (May 30, 2021): 074–86. http://dx.doi.org/10.30574/ijsra.2021.2.2.0250.

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It is well known from FDA reports that More than 75% of the heterocyclic compounds are drugs and 90 of heterocyclic compounds are cancer drugs. The nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. Most drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties, More over heterocyclic compounds are important class of organic chemistry due to their widely spread in nature. Also there are many route for their action and many mechanistic pathways for their preparation and different metabolic actions. This comes from the easily building or removal of any functional group within the molecules. Changing just on group cause to change the metabolic pathway of the drug action and site of attack of the desired target accordingly. This great characteristic value make them much more important in drug discovery programs of many researchers and also encouraged us and drew attentions of other researchers to develop new ways for their synthesis. As a result different pharmacological and medical applications. Oxazie compounds are sub branch of heterocyclic compounds. These compounds having two hetero atoms, Oxygen and nitrogen within their structures make them much more important toward therapeutic studies. We are here in our investigation will focus on the methodologies and the therapeutic action of the titled compounds as well as other various applications.

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Aly, Ashraf A., Alaa A. Hassan, Maysa M. Makhlouf, and Stefan Bräse. "Chemistry and Biological Activities of 1,2,4-Triazolethiones—Antiviral and Anti-Infective Drugs." Molecules 25, no. 13 (July 3, 2020): 3036. http://dx.doi.org/10.3390/molecules25133036.

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Mercapto-substituted 1,2,4-triazoles are very interesting compounds as they play an important role in chemopreventive and chemotherapeutic effects on cancer. In recent decades, literature has been enriched with sulfur- and nitrogen-containing heterocycles which are used as a basic nucleus of different heterocyclic compounds with various biological applications in medicine and also occupy a huge part of natural products. Therefore, we shed, herein, more light on the synthesis of this interesting class and its application as a biologically active moiety. They might also be suitable as antiviral and anti-infective drugs.

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Giuglio-Tonolo, Alain G., Christophe Curti, Thierry Terme, and Patrice Vanelle. "A Survey of Synthetic Routes and Antitumor Activities for Benzo[g]quinoxaline-5,10-diones." Molecules 25, no. 24 (December 14, 2020): 5922. http://dx.doi.org/10.3390/molecules25245922.

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Anthracycline antibiotics play an important role in cancer chemotherapy. The need to improve their therapeutic index has stimulated an ongoing search for anthracycline analogs with enhanced properties. This review aims to summarize the common synthetic approaches to benzo[g]quinoxaline-5,10-diones and their uses in heterocyclic chemistry. Because of the valuable biological activities of the 1,4-diazaanthraquinone compounds, a summary of the most promising heterocyclic quinones is provided together with their antitumor properties.

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Ghahsare, Aref G., Zahra S. Nazifi, and Seyed M. R. Nazifi. "Structure-Bioactivity Relationship Study of Xanthene Derivatives: A Brief Review." Current Organic Synthesis 16, no. 8 (January 20, 2020): 1071–77. http://dx.doi.org/10.2174/1570179416666191017094908.

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: Over the last decades, several heterocyclic derivatives compounds have been synthesized or extracted from natural resources and have been tested for their pharmaceutical activities. Xanthene is one of these heterocyclic derivatives. These compounds consist of an oxygen-containing central heterocyclic structure with two more cyclic structures fused to the central cyclic compound. It has been shown that xanthane derivatives are bioactive compounds with diverse activities such as anti-bacterial, anti-fungal, anti-cancer, and anti-inflammatory as well as therapeutic effects on diabetes and Alzheimer. The anti-cancer activity of such compounds has been one of the main research fields in pharmaceutical chemistry. Due to this diverse biological activity, xanthene core derivatives are still an attractive research field for both academia and industry. This review addresses the current finding on the biological activities of xanthene derivatives and discussed in detail some aspects of their structure-activity relationship (SAR).

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Salotra, Riddhi, and Divya Utreja. "A Comprehensive Appraisal of Chalcones and Their Heterocyclic Analogs as Antimicrobial Agents." Current Organic Chemistry 24, no. 23 (December 28, 2020): 2755–81. http://dx.doi.org/10.2174/1385272824999200922090524.

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Owing to the growing demand for compelling antimicrobial agents, chalcones and their heterocyclic derivatives have engrossed prodigious attention of medicinal chemists as an effective clinical template for the synthesis of such agents on account of their structural diversity and molecular flexibility. Chalcones are considered as a fortunate scaffold in the field of both synthetic as well as natural product chemistry. They are reflected as a remarkable section of logically occurring pharmacophores that possess a comprehensive scale of biological activities, such as anti-cancer, anti-malarial, anti-viral and anti-inflammatory, rendering them with a high degree of assortment and noble therapeutic profile. They act as a crucial intermediate for the synthesis of novel heterocyclic skeletons holding biodynamic behavior. This review emphasizes on different aspects of chalcones including their natural sources, recent synthetic methodologies and evaluation of their anti-microbial potential. It is expected as a persuasive compilation on chalcones that may benefit the experts to design potent and less toxic chalcone referents as medicinal agents.

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Sharma, Sachin, Gaurav Joshi, Sourav Kalra, Sandeep Singh, and Raj Kumar. "Synthetic Versus Enzymatic Pictet-Spengler Reaction: An Overview." Current Organic Synthesis 15, no. 7 (October 16, 2018): 924–39. http://dx.doi.org/10.2174/1570179415666180613084014.

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Background: Pictet-Spengler reactions is an irreplaceable part of cyclization reaction leading to the formation of indispensable heterocyclic moieties including imidazole, benzoxazole, pyrrole, indole and others having immense biological and chemical significance. Researchers have explored this reaction using different types of catalysts and reactions conditions (including solvents, acids, etc.) to ensure the better selectivity, less reaction time and high product yields. A total of five Pictet-Spenglerases have been discovered from various sources including plants, animals, fungi, and microbes, and are responsible for the synthesis of various important alkaloids of biological medicinal importance. Objective: The present review is a strenuous effort to assemble information mainly focusing on synthetic as well as biological Pictet-Spengler reactions catalysed by enzymes called Pictet-Spenglerase. Conclusion: In the present review, the recent advances in the PS-mediated synthesis of diverse heterocycles such as tetrahydroisoquinoline, tetrahydro-β-carbolines, tetrahydroimidazopyridines and other fused heterocycles via chemical as well as enzymatic pathways have been covered. The compounds find their scope as medicinal agents for the treatment of cancer, tuberculosis, bacterial infection, leishmanial, etc. The compilation is expected to provide a mechanistic insight to chemists to enhance the reaction condition, yields and another parameter to ensure the safe and inexpensive reaction conditions considering the “Green-Concept” of chemistry.

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Dissertations / Theses on the topic "Heterocyclic chemistry; Cancer"

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Barlow, Hanna Castell. "Design and synthesis of pyrimidopyrimidine modulators of nucleoside transport." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310026.

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Chuckowree, Irina S. "Heterocyclic compounds for the treatment of cancer : a mechanistic rationale." Thesis, University of Greenwich, 2010. http://gala.gre.ac.uk/8097/.

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Britton, A. M. "Complexes of heterocyclic thiones and thiolates with nickel (II) and the platinum metals." Thesis, University of Newcastle Upon Tyne, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383557.

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Miles, Meredith. "The Great Potential of Redox Active Ligands: Applications in Cancer Research and Redox Active Catalysis." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1546621531283595.

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Wazeerud-Din, Idris. "Synthetic Approaches towards Novel Isoform Selective PI3K Inhibitors and Their Biological Activities against Prostate Cancer Cells." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2018. http://digitalcommons.auctr.edu/cauetds/143.

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The development of novel imidazopyridines, which includes both tetrahydroimidazo[1,5-a]pyridine (rIMP) and imidazo[1,5-a]pyridine (IMP) was investigated using conventional and microwave induced procedures that afforded compounds at high yield of 88-96%. rIMP was synthesized using a two-step procedure that involved the microwave synthesis of IMP, then the reduction of the pyridine moiety of the fused imidazopyridine rings using 10% Pd/C and hydrazine monohydrate. The microwave synthesis of imidazopyridines involved the one pot reaction of 2-benzoylpyridine, substituted benzaldehyde and ammonium formate in acetic acid under open vessel microwave conditions, which resulted in products within 40 minutes. Novel PEG-IMP development, involved the synthesis of ethylene glycol tethered benzaldehydes and IMPs using traditional Williamson etherification synthesis, which afforded products at a high yield of 92-95%. We have then shown IMP and rIMP roles in its antiproliferative property towards PCa cells, specificity in inhibiting PI3K isoforms, and structural motif’s interaction with different residues in the kinase binding domain of the class I PI3K isoforms. The antiproliferative property towards PC3 cells shows increased activity with compounds containing pyridyl group on carbon 3 of the imidazo[1,5-a]pyridine parent moiety with signs of toxicity to PC3 within 24 hours of incubation and at 1 μM of the parent compound. Furthermore, the IMPs were tested against five prostate cellular lines: PC3, RWPE1, D145, LNCaP and LNCaP C81. IMPs showed little activity towards RWPE1 and increased activity towards PC3 cells. We determined that functionalizing the phenyl group at position 1 increased the efficacy of rIMP compared to the IMP. After showing increased toxicity to PC3 cells, it was important to investigate the mechanism in which IMP pose toxicity towards PC3 cells. The biochemical assay showed that rIMP was more effective in inhibiting PI3Kα isoform compared to both pan inhibitor wortmannin and IMP. Both IMP and rIMP inhibited more than 60% of PI3Kγ isoform activity at nanomolar concentrations. After showing IMPs affinity to PI3K isoforms, we investigated the binding interactions rIMP and IMP towards the PI3K isoforms using MOE molecular modeling software.

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Robishaw, Nikki K. "Encapsulating N-heterocyclic carbene complexes into biodegradable nanoparticles and the antimicrobial and antitumor effects." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1530222031725709.

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Kavouris, John A. "Mannich reactions and the synthesis of heterocycles as antiproliferative agents in cancer and neglected tropical disease." Thesis, 2020. https://hdl.handle.net/2144/42664.

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Efficient construction of C-N bonds and nitrogen-containing heterocycles is instrumental in synthesizing chemical building blocks with direct applicability to the pharmaceutical industry. Three projects incorporating this theme to address unmet scientific challenges are reported herein: quinolinone inhibitors of LSF, pyrazolopyrrolidnones for the treatment of leishmaniasis, and an asymmetric Petasis reaction to synthesize chiral 1,2-amino alcohols. Quinolinone inhibitors of LSF, an oncogenic transcription factor overexpressed in several liver cancers, were previously reported as potential cancer therapies, however; they exhibited poor oral bioavailability, and the series was optimized for improved pharmacokinetics. Newly synthesized analogs demonstrate nanomolar potency against liver cancer cells in vitro with improved pharmacokinetic properties. Furthermore, the synthetic route was optimized to deliver lead compounds in multi-gram quantities, and to establish regio-control over the final intramolecular Friedel-Crafts cyclization. A series of pyrazolopyrrolidinones was developed to address an unmet medical need for new treatments against the parasitic disease leishmaniasis. Over 200 analogs were generated via parallel synthesis, which were assayed in a high-throughput phenotypic screen and many demonstrated low-micromolar to nanomolar potency against Leishmania parasites in vitro. SAR trends and in vivo pharmacokinetic and efficacy studies identified a critical balance between physiochemical properties (solubility, lipophilicity, plasma protein binding) and potency that appear to limit expected in vivo efficacy. These trends informed subsequent analog design to further optimize the physiochemical properties for in vivo efficacy, with further studies pending. Chiral 1,2-amino alcohols are valuable building blocks found in drugs, natural products, and organocatalysts. To enable their synthesis, an asymmetric multicomponent Petasis reaction was developed using boronic acids or boronates, primary or secondary amines, and glycolaldehyde, catalyzed by chiral biphenols. The reactions are run in ethanol or trifluorotoluene with commercially available starting materials, accommodate electron deficient and electron rich boron reagents, and afford products in up to 99% yield and >99:1 er. The reaction is scalable to generate decagram quantities of product, and an extractive purification procedure allows for chromatography-free product isolation and catalyst recovery.
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Mitra, Raja. "Targeted Delivery of Cytotoxic Metal Complexes into Cancer Cells with and without Macromolecular Vehicles." Thesis, 2013. http://etd.iisc.ernet.in/2005/3392.

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Anticancer active metal complexes such as cisplatin are routinely used for treating various cancers since 1978. However, the side effects of cisplatin overwhelm its therapeutic potential, especially in the latter stages of treatment. The nonspecific cytotoxicity of drugs could be avoided if targeted delivery to cancer cells is achieved using two different methodologies namely, enhanced permeability and retention in solid tumors (EPR) and receptor mediated endocytosis using a homing agent (RME). Ru(II)-arene complexes which are delivered specifically into cancer cells by the transferrin enzyme are less toxic compared to other metal complexes. The thesis describes the synthesis and use of Ru(II)-η6cymene complexes with different ancillary ligands which modulates the anticancer activity and the utility of two macromolecular vehicles in directed drug delivery. Ru(II)-η6cymene complexes with different heterocyclic ancillary ligands are synthesized and their anticancer activity tested against various cancer cell lines. Ruthenium complexes with mercaptobenzothiazoles are found to be quite active against the H460 cell lines that overexpress transferrin receptors and non-cytotoxic to the normal cell line, HEL299. Biophysical studies show that complexes (H1 and H8) can unwind the pBR322 DNA and inhibit the Topo IIα enzyme. A unique biphasic melting curve of CT DNA is observed in the presence of H1 which is attributed to formation of a dinuclear species (H20). Half-sandwich complexes of 6-thioguanine (6-TG) have also been prepared to improve the delivery and efficacy of 6-TG which is used in spite of a deleterious photoreaction. The Ru complexes cytotoxic to several leukemia cell lines. As they are photostable and anticancer active, they are better than 6-TG. Anticancer activity exhibiting piazselenols are used as ancillary ligands to make Ru(II)-arene complexes. Unfortunately, 1H NMR spectra suggests that piazselenol complexes dissociate in solution. However, the nitro substituted piazselenol and its Ru complex show the greatest cytotoxicity (<0.1 µM) against the A2780 cell line. The utility of PAMAM dendrimers and hyper branched polymers (hybramers) conjugated with a homing agent to target cancer cells by EPR and RME is probed. A cytotoxic copper complex (CuATSM) is covalently attached to the macromolecules through a disulfide linker, cleaved in the presence of GSH. Targeting efficacy of the folic acid-dendrimer conjugates is checked against two glioma cell lines. The folic acid-dendrimer conjugate is more active compared to dendrimer conjugate without folic acid against folate-receptor-overexpressing LN18 cell line. Biotin conjugated dendrimer shows better accumulation in HeLa cells, which require high amounts of biotin for growth. In vivo studies demonstrate that the conjugate can cross the blood-brain barrier. These studies suggest that PAMAM dendrimer can be used as a targeted delivery vehicle for cytotoxic metal complexes. Hyperbranched polymers decorated with propargyl groups and hydrophilic OH terminated TEG groups are attached to biotin and a cytotoxic Cu complex. (CuATSM-SS-CONH-N3) through ‘click’ reactions and tested against the HeLa cell line. On the basis of the studies conducted, it is concluded that targeted delivery of cytotoxic metal complexes are possible in the case of Ru(II) half-sandwich complexes and macromolecular vehicles like dendrimers are suitable for specifically delivering copper complexes into cancer cells.

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Book chapters on the topic "Heterocyclic chemistry; Cancer"

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Zhang, Shunqing, Nayan J. Patel, and Ravindra K. Pandey. "Chlorophyll-a Analogs for Cancer Imaging and Therapy (Theranostics)." In Topics in Heterocyclic Chemistry, 1–30. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/7081_2013_117.

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Ali, Amanat, Mostafa I. Waly, and Sankar Devarajan. "Chapter 11. Impact of Processing Meat on the Formation of Heterocyclic Amines and Risk of Cancer." In Food Chemistry, Function and Analysis, 187–211. Cambridge: Royal Society of Chemistry, 2019. http://dx.doi.org/10.1039/9781788015813-00187.

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Ishibashi, Masami. "Bioactive Heterocyclic Natural Products from Actinomycetes Having Effects on Cancer-Related Signaling Pathways." In Progress in the Chemistry of Organic Natural Products 99, 147–98. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-04900-7_3.

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Seeberger, Peter H. "Automated Solid Phase Synthesis of Blood Group Determinants and Cancer Vaccines." In 19th International Congress on Heterocyclic Chemistry, 66. Elsevier, 2003. http://dx.doi.org/10.1016/b978-0-08-044304-1.50059-9.

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Parker, Laurie L., and David J. Robins. "Synthesis of Novel Macrocyclic Polyamine Complexes for Use as Anti-cancer Prodrugs." In 19th International Congress on Heterocyclic Chemistry, 299. Elsevier, 2003. http://dx.doi.org/10.1016/b978-0-08-044304-1.50291-4.

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Tong, Ka-Chung, Di Hu, Pui-Ki Wan, Chun-Nam Lok, and Chi-Ming Che. "Anti-cancer gold, platinum and iridium compounds with porphyrin and/or N-heterocyclic carbene ligand(s)." In Medicinal Chemistry, 87–119. Elsevier, 2020. http://dx.doi.org/10.1016/bs.adioch.2019.10.012.

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Conference papers on the topic "Heterocyclic chemistry; Cancer"

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Pogorzelska, Aneta, Jarosław Sławiński, Anna Kawiak, and Joanna Jasińska. "Novel N-(2-Mercaptobenzenesulfonyl)guanidine Derivatives Modified by Nitrogen-containing Heterocycles – Synthesis and Antiproliferative Activity Against Human Cancer Cell Lines." In 3rd International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2017. http://dx.doi.org/10.3390/ecmc-3-04675.

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