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Relevant bibliographies by topics / Heterocyclic moiety

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Academic literature on the topic 'Heterocyclic moiety'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Heterocyclic moiety"

1

Romero-Hernández, Laura L., Ana Isabel Ahuja-Casarín, Penélope Merino-Montiel, Sara Montiel-Smith, José Luis Vega-Báez, and Jesús Sandoval-Ramírez. "Syntheses and medicinal chemistry of spiro heterocyclic steroids." Beilstein Journal of Organic Chemistry 20 (July 24, 2024): 1713–45. http://dx.doi.org/10.3762/bjoc.20.152.

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There is compelling evidence that incorporating a heterocyclic moiety into a steroid can alter its pharmacological and pharmacokinetic properties, driving intense interest in the synthesis of such hybrids among research groups. In this review, we present an overview of recent synthetic methodologies, spanning the period from 2000 to 2023, for the preparation of spiro heterocyclic steroids. The compounds surveyed encompass four-, five-, six-, and seven-membered heterocycles appended to various positions of steroidal backbones, with spirocycles containing oxygen, nitrogen, and sulfur atoms being

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Ahuja, Aarohi, Ujjwal Prakash Jajodia, Abhishek Shandilya, and Anil Kumar Koshal. "Tailaring, Characterization, & Microbiological Evaluation of Heterocyclic Moiety." International Journal of Science and Research (IJSR) 11, no. 11 (2022): 1379–81. http://dx.doi.org/10.21275/sr221122205319.

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Abdel Hafez, Ali A. "Synthesis of Some Heterocyclic Sulfones Related to Quinolinol." Collection of Czechoslovak Chemical Communications 58, no. 9 (1993): 2222–26. http://dx.doi.org/10.1135/cccc19932222.

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It is well known that pyrazolone derivatives possess antifungal and antibacterial activities. Pyrazole and isoxazole derivatives are widely used in medicinal chemistry. In continuation of our work on the synthesis of heterocycles containing the quinoline moiety we synthesized different heterocyclic sulfones related to quinolinol.

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Mir, Reyaz Hassan, Roohi Mohi-ud-din, Taha Umair Wani, et al. "Indole: A Privileged Heterocyclic Moiety in the Management of Cancer." Current Organic Chemistry 25, no. 6 (2021): 724–36. http://dx.doi.org/10.2174/1385272825666210208142108.

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Heterocyclic are a class of compounds that are intricately entwined into life processes. Almost more than 90% of marketed drugs carry heterocycles. Synthetic chemistry, in turn, allocates a cornucopia of heterocycles. Among the heterocycles, indole, a bicyclic structure consisting of a six-membered benzene ring fused to a five-membered pyrrole ring with numerous pharmacophores that generate a library of various lead molecules. Due to its profound pharmacological profile, indole got wider attention around the globe to explore it fully in the interest of mankind. The current review covers recent

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Abdel Hafez, Ali A., Ibrahim M. A. Awad, and Raga A. Ahmed. "New Heterocyclo-Substituted Pyrazolo[3,4-b]pyridine Derivatives." Collection of Czechoslovak Chemical Communications 58, no. 5 (1993): 1198–202. http://dx.doi.org/10.1135/cccc19931198.

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In this investigation and in continuance with our previous work in the synthesis of some heterocyclic compounds fused with pyridine moiety, we used 3-amino-4,6-diphenyl-1H-pyrazolo[3,4-b]pyridine (II) as starting material to synthesize many heterocyclic compounds containing pyrazolopyridine moiety.

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Fernandes, Sara S. M., Maria Cidália R. Castro, Dzmitry Ivanou, Adélio Mendes, and Maria Manuela M. Raposo. "Push-Pull Heterocyclic Dyes Based on Pyrrole and Thiophene: Synthesis and Evaluation of Their Optical, Redox and Photovoltaic Properties." Coatings 12, no. 1 (2021): 34. http://dx.doi.org/10.3390/coatings12010034.

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Three heterocyclic dyes were synthesized having in mind the changes in the photovoltaic, optical and redox properties by functionalization of 5-aryl-thieno[3,2-b]thiophene, 5-arylthiophene and bis-methylpyrrolylthiophene π-bridges with different donor, acceptor/anchoring groups. Knoevenagel condensation of the aldehyde precursors with 2-cyanoacetic acid was used to prepare the donor-acceptor functionalized heterocyclic molecules. These organic metal-free dyes are constituted by thieno[3,2-b]thiophene, arylthiophene, bis-methylpyrrolylthiophene, spacers and one or two cyanoacetic acid acceptor

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Khramtsova, Ekaterina E., Aleksandr D. Krainov, Maksim V. Dmitriev, and Andrey N. Maslivets. "Cycloaddition of 4-Acyl-1H-pyrrole-2,3-diones Fused at [e]-Side and Cyanamides: Divergent Approach to 4H-1,3-Oxazines." Molecules 27, no. 16 (2022): 5257. http://dx.doi.org/10.3390/molecules27165257.

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4-Acyl-1H-pyrrole-2,3-diones fused at [e]-side with a heterocyclic moiety are suitable platforms for the development of a hetero-Diels–Alder-reaction-based, diversity-oriented approaches to series of skeletally diverse heterocycles. These platforms are known to react as oxa-dienes with dienophiles to form angular 6/6/5/6-tetracyclic alkaloid-like heterocycles and are also prone to decarbonylation at high temperatures resulting in generation of acyl(imidoyl)ketenes, bidentate aza- and oxa-dienes, which can react with dienophiles to form skeletally diverse products (angular tricyclic products or

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Dave, Jayrang S., and Meera Menon. "Azomesogens with a heterocyclic moiety." Bulletin of Materials Science 23, no. 3 (2000): 237–38. http://dx.doi.org/10.1007/bf02719917.

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Egbujor, Melford C., Paolo Tucci, Ugomma C. Onyeije, Chigbundu N. Emeruwa, and Luciano Saso. "NRF2 Activation by Nitrogen Heterocycles: A Review." Molecules 28, no. 6 (2023): 2751. http://dx.doi.org/10.3390/molecules28062751.

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Several nitrogen heterocyclic analogues have been applied to clinical practice, and about 75% of drugs approved by the FDA contain at least a heterocyclic moiety. Thus, nitrogen heterocycles are beneficial scaffolds that occupy a central position in the development of new drugs. The fact that certain nitrogen heterocyclic compounds significantly activate the NRF2/ARE signaling pathway and upregulate the expression of NRF2-dependent genes, especially HO-1 and NQO1, underscores the need to study the roles and pharmacological effects of N-based heterocyclic moieties in NRF2 activation. Furthermor

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Li, Jinghua, and Lushan Wang. "Elucidation of the Mechanism for the S - N-type Smiles Rearrangement on Pyridine Rings." Australian Journal of Chemistry 62, no. 2 (2009): 176. http://dx.doi.org/10.1071/ch08205.

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The Smiles rearrangement (SR) is an important strategy for synthesizing heterocyclic compounds. Many pyridine moiety-containing complexes are biologically active. Although the success has been archived in the development of the SR on the pyridine ring to obtain pyridine moiety-containing heterocyclic compounds, not much is known about the detailed SR mechanism. Here, we report a theoretical study on a typical S–N-type SR reaction involved in the synthesis of thiazinone-fused pyridines. We studied both the ipso-SR process and the direct nucleophilic substitution reactions on the ortho-positions

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Dissertations / Theses on the topic "Heterocyclic moiety"

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Engqvist, Robert. "Syntheses of some tri- and tetracyclic heterocycles containing an indole moiety /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-161-X/.

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Downing, Stephen Paul. "Studies of N-heterocyclic carbenes functionalised with a cyclopentadienyl type moiety." Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439577.

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Banert, Klaus. "Acremolin, a stable natural product with an antiaromatic 1H-azirine moiety? A structural reorientation." Universitätsbibliothek Chemnitz, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-153824.

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Recently, acremolin (4), a novel modified base, was isolated from a marine-derived fungus and claimed to possess a structure with a 1H-azirine moiety. It is shown now that the reported NMR data are not compatible with this antiaromatic heterocycle, which should be an extremely unstable compound. An isomeric, substituted N2,3-ethenoguanine is presented as a plausible alternative structure of acremolin that is consistent with all spectroscopic data. Thus, 1H-azirines keep their classification as very short-lived intermediates.

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Banert, Klaus. "Acremolin, a stable natural product with an antiaromatic 1H-azirine moiety? A structural reorientation." Technische Universität Chemnitz, 2012. https://monarch.qucosa.de/id/qucosa%3A20131.

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Recently, acremolin (4), a novel modified base, was isolated from a marine-derived fungus and claimed to possess a structure with a 1H-azirine moiety. It is shown now that the reported NMR data are not compatible with this antiaromatic heterocycle, which should be an extremely unstable compound. An isomeric, substituted N2,3-ethenoguanine is presented as a plausible alternative structure of acremolin that is consistent with all spectroscopic data. Thus, 1H-azirines keep their classification as very short-lived intermediates.

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Wei-Yi, Lee, and 李威逸. "Highly organsoluble and thermally stable heterocyclic polyimide with carbazole moiety group: synthesis, electrochemical, electrochromic, optical, and protonation chatacterization." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/454443.

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碩士<br>國立臺灣科技大學<br>化學工程系<br>95<br>A new diamine containing pyridine heterocyclic group and carbazole substituent units, 4-(9-ethyl-3-carbazole)-2,6-bis(4-aminophenyl)pyridine (CBAPP, 2), was synthesized and used in a preparation of poly(pyridine-imide) PI-1~7 by direct polycondensation with 4,4'-hexafluoroisopropylidenediphathalic anhydride (6FDA) 3,3',4,4'-diphenylsulfonetetracarboxylic dianhydride(DSDA), 3,3',4,4'-benzophenonetetracarboxylic dianhydride (BTDA), 4,4'-oxydiphthalic anhydride (ODPA), 4,4'-biphthalic anhydride (BPDA), pyromellitic dianhydride (PMDA) and m-DAN in N-methyl-2-pyrrol

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Simatupang, Masdinar Ida, and Masdinar Ida Simatupang. "Synthesis, Structures, and Photophysical Properties of Luminescent Ruthenium Complexes Bearing Unsymetrical Ligand with Normal and Abnormal N-Heterocyclic Carbene Donors and Terpyridine Moiety." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/uwxm7m.

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碩士<br>國立東華大學<br>化學系<br>104<br>Two unsymmetric ligands with a normal and an abnormal N-heterocyclic donors in the pyridine-based pincer type ligand and their heteroleptic Ru(II) complexes using terpyridine moiety as an auxiliary ligand, [Ru(LA)(tpy)](BF4)2 and [Ru(LB)(tpy)](BF4)2, have been synthesized. The structrure of [Ru(LB)(tpy)]2+ has been characterized. The methylene bridge on Cimidazole‒Ru‒Npyridine, lead to an ideal octahedral geometry i.e 89.59o. The strongly σ-donating and weakly π-accepting unsymmetric tridentate carbene ligand system adjacent to the terpy auxiliary ligand resulted

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Haung, Kai-Chiang, and 黃凱強. "Syntheses and Properties of Discotic Liquid Crystals Based on a Novel Heterocyclic mesogenic core of Diphenanthro[9,10-a:9',10'-i]phenazine and Ferroelectric Liquid Crystals Containing a 1-[(2S)-2-Methylbutoxy]- (2S)-2-propanol Moiety." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/83493795984742903568.

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碩士<br>國立臺灣科技大學<br>化學工程系<br>91<br>Abstracts The synthesis and properties of discotic liquid crystals, the diphenanthro [9,10-a:9',10'-i]phenazines [SchemeⅠ(6)], is reported in which the length of the peripheral alkoxy-substituted side groups is varied from 4 and 9 carbon atoms. 4,5-Bis[3,4-di(alkoxy)phenyl]benzene-1,2-diamine (n = 4 - 9) [SchemeⅠ(4)] was chosen as a key synthon and prepared by palladium on carbon (5%) at room temperature and 5 atm pressure in ethyl acetate hydrogenation of the corresponding nitro compound of 4,5-Bis[3,4-di(alkoxy)phenyl]-1,2-dinitrobenzene [SchemeⅠ(3

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Book chapters on the topic "Heterocyclic moiety"

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Khalifa, Zebabanu, Rachana Upadhyay, Premlata Kumari, and Amit B. Patel. "Current Development in the Synthesis of Benzimidazole-Quinoline Hybrid Analogues and their Biological Applications." In Strategies Towards the Synthesis of Heterocycles and Their Applications [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108949.

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Heterocyclic compounds have an essential role in many domains of medicinal chemistry. Many pharmaceutical industries use and investigate nitrogen-containing heterocycles because they are crucial in discovering and developing novel therapeutically active compounds. The benzimidazole moiety is a fundamental component of many heterocyclic scaffolds, which play an important role in producing a wide range of biological activities. Similarly, quinoline is also a versatile bicyclic heterocyclic scaffold with many medicinal applications. It is an essential scaffold for drug discovery leads, and it pla

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Tiwari, Aditi, Anjaneyulu Bendi, and Anirudh Singh Bhathiwal. "Carbazoles and their Derivatives as Anti-inflammatory agents." In Heterocyclic Anti-Inflammatory Agents: A Guide for Medicinal Chemists. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815223460124010010.

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Heterocyclic compounds refer to a defining class of organic compounds with vast biological applications. Heterocyclic compounds are of great significance to life for the reason that they are abundantly present in nature, such as in the form of antibiotics, hormones, vitamins, and many more. Among heterocyclic compounds, nitrogen-based heterocycles are of special biological use because of their boundless medicinal and biological applications. Carbazoles are one of several nitrogen-based, biologically active heterocyclic compounds with the chemical formula C12H9N. Carbazole moiety has diverse ph

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Arán, Vicente J., Pilar Goya, and Carmen Ochoa. "Heterocycles Containing the Sulfamide Moiety." In Advances in Heterocyclic Chemistry Volume 44. Elsevier, 1988. http://dx.doi.org/10.1016/s0065-2725(08)60262-7.

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Naushad, Edayadulla, and Shankar Thangaraj. "Naturally Isolated Pyridine Compounds Having Pharmaceutical Applications." In Chemistry with Pyridine Derivatives [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.106663.

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Heterocyclic moieties form important constituents of biologically active natural products and synthetic compounds of medicinal interest. Nitrogen heterocycles constitute important pharmacophores in drug design, especially pyridine derivatives, which are among the most frequently cited heterocyclic compounds. The isolated as well as synthesized pyridine compounds exhibited various pharmacological properties due to their diverse physiochemical properties like water solubility, weak basicity, chemical stability, hydrogen bond-forming ability, protein-binding capacity, cell permeability, and size

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Thatikayala, Mahender, Anil Kumar Garige, and Hemalatha Gadegoni. "Benzimidazole: Pharmacological Profile." In Benzimidazole [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102091.

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Benzimidazole is a bicyclic heterocyclic aromatic compound in which benzene fused to imidazole moiety. Benzimidazole holds a vital role in the field of medicinal chemistry which possesses wide variety of pharmacological activities like antibacterial, anti cancer, antifungal, antileishmanial, anti tubercular, anti viral and anti malarial respectively, hence the benzimidazole moiety attracting the medicinal chemist to synthesize the different benzimidazole derivatives with wide variety of pharmacological activities. The book chapter mainly discussed the anti cancer, anti HIV, antileishmanial and

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Das, Dipankar, Arpita Das, Sourav Sutradhar, Parnashabari Sarkar, and Biswa Nath Ghosh. "Synthesis, Properties, and Biological Applications of Thiophene." In S-Heterocycles. Royal Society of Chemistry, 2024. http://dx.doi.org/10.1039/9781837674015-00317.

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Thiophene, a five-membered heterocyclic moiety containing one sulfur atom, possesses aromaticity. Among the sulfur-containing heterocyclic receptor systems, the synthesis of thiophene and its derivatives has drawn significant attention in the field of pharmaceutical chemistry for exhibiting a wide range of biological activities. Substituted thiophene derivatives and thiophene fused heterocyclic moieties display numerous biological activities, including antibacterial, anticancer, anticonvulsant, antithrombotic, antileishmanial, anti-inflammatory, and antifungal activities. As thiophene improves

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Unnamatla, M. V. Basavanag, Fazlur-Rahman Nawaz Khan, and Erick Cuevas Yañez. "Tetrazoles: Structure and Activity Relationship as Anticancer Agents." In Key Heterocyclic Cores for Smart Anticancer Drug–Design Part I. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815040074122010008.

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Heterocyclic compounds play an important role in drug design and discovery, and they have been used to treat a variety of diseases, including cancer. Cancer is one of the leading causes of death in the world. However, various drugs and therapies are available on the market. The novel synthetic drugs show promising in vitro activity, but the route to clinical trials is hampered by their low bioavailability and rapid metabolism. Tetrazoles have gained a lot of attention in recent years because they have the broadest biological activity spectrum of any heterocycle. Tetrazoles are a type of nitrog

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Fujisaki, H., T. Ishizuka, and T. Kojima. "Iron Complexes as Bio-inspired Catalysts for Efficient and Selective Oxidation of Organic Compounds." In Iron in Biology. Royal Society of Chemistry, 2025. https://doi.org/10.1039/9781837677979-00195.

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In this chapter, we describe a strategy for efficient and selective catalytic oxidation of organic substrates such as methane and aromatics in aqueous media. In this strategy, pentadentate ligands containing one N-heterocyclic carbene (NHC) moiety were employed as ancillary ligands of triplet FeIV–oxo complexes. The FeIV–oxo species show strong oxidation activity owing to the strong trans-influence of the NHC moiety. Upon introducing bulky aromatic substituents to the NHC ligand, the hydrophobic second coordination sphere (SCS) was successfully formed to surround the FeIV–oxo moiety and achiev

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Newton, Russell P. "Mass spectrometric analysis of cyclic nucleotides and related enzymes." In Applications of Modern Mass Spectrometry in Plant Science Research. Oxford University PressOxford, 1996. http://dx.doi.org/10.1093/oso/9780198549659.003.0011.

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Abstract Cyclic nucleotides perform a vital role in the regulation of cellular metabolism. Structurally they are composed of a heterocyclic base, a ribose sugar, and a cyclic phosphate moiety (Fig. 11.1). The latter can be linked to the ribose ring at either the 3’,5’-positions or the 2’,3’-positions, giving rise to two sets of isomers; of these two sets it is the 3’,5’-cyclic nucleotides which are of importance in the context of metabolic regulation, with the 2’,3’isomers arising merely as intermediates in the catabolism of ribonucleic acids.

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Kundlikar, Sarita G., Hemantkumar N. Akolkar, Dilip R. Thube, Nirmala R. Darekar, and Vijay M. Khedkar. "Benzothiazepine." In Advances in Bioinformatics and Biomedical Engineering. IGI Global, 2024. http://dx.doi.org/10.4018/979-8-3693-7520-4.ch011.

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Benzothiazepines are the heterocyclic compounds with a benzene ringfused with sulphur and nitrogen containing seven membered thiazepine ring. Benzothiazepines can be of 1,2-, 1,4- and 1,5- derivatives depending on the varied positions of sulphur and nitrogen in thiazepine ring. These benzothiazepine derivatives has druggable potential in therapeutic medicine for drug development and drug discovery.Benzothiazepine derivatives are endowed with various pharmacological activities like antipsychotic agents, calcium channel antagonists, cytochrome bc1 inhibitors, antidepressants, anticonvulsants etc

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Conference papers on the topic "Heterocyclic moiety"

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Al-Jamal, Mazin, and Naeemah Al-Lami. "Antimicrobial activities of some new heterocyclic compounds bearing imidazo[2,1-b]benzothiazole moiety." In 2ND INTERNATIONAL CONFERENCE ON MATHEMATICAL TECHNIQUES AND APPLICATIONS: ICMTA2021. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0103153.

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Verdes, Anastasia, Elena Gorincioi, Lucian Lupascu, Gheorghe Duca, and Fliur Macaev. "Targeting the bioactive dihydropyrimidines by ecofriendly procedure of biginelli reaction: study case of monastrol." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab24.

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Biologically active compounds decorated with dihydropyridine moiety are counted amongst the numerous broad-spectrum therapeutic agents that explain the increasing role of this scaffold in rational drug design [1]. The Biginelli reaction is a multicomponent reaction of aldehyde, (thio)urea, and ß-ketoester, involving Mannich reaction in the first step, which produces multifunctionalized 3,4-dihydropyrimidin-2-(1H)-ones and related heterocyclic compounds [2]. The attractiveness of this acid-catalyzed one-pot condensation reaction lies in the simplicity of grafting the substituent into the struct

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Yang, Zhen, Yefei Wang, Matjaž Finšgar, Jiajia Wu, and Wengang Ding. "Novel High-Efficient Key Component of Steel Corrosion Inhibitors Formulation for Acidification: Indolizine Derivatives of the Conventional N-Heterocyclic Quaternary Ammonium Salts." In SPE International Conference on Oilfield Chemistry. SPE, 2023. http://dx.doi.org/10.2118/213814-ms.

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Abstract Acidizing, the widely used technique for well stimulation, requires a great consumption of effective Corrosion Inhibitors (CIs), due to the severe and fast corrosion of metallic equipment caused by strong hot acid as soon as the acidizing fluids are pumping down to reservoir. This paper presents a new concept of indolizine derivative inhibitors with remarkable inhibition effectiveness for steel under acidizing condition, which will reduce the cost and environmental burden of acidizing CIs significantly. Indolizine derivatives of several quinolinium salts (serves as main component of c

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Affeldt, Ricardo F., Dennis Russowsky, and Fabiano S. Rodembusch. "Novel Photoactive N-Heterocycles Bearing a Benzoxazole Moiety: Synthesis and Photophysical study." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0156-1.

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