Relevant bibliographies by topics / Heterocyclic natural product biosynthesis

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Academic literature on the topic 'Heterocyclic natural product biosynthesis'

Author: Grafiati
Published: 4 June 2021
Last updated: 8 February 2022

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Journal articles on the topic "Heterocyclic natural product biosynthesis"

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Meng, Song, Gong-Li Tang, and Hai-Xue Pan. "Enzymatic Formation of Oxygen-Containing Heterocycles in Natural Product Biosynthesis." ChemBioChem 19, no. 19 (2018): 2002–22. http://dx.doi.org/10.1002/cbic.201800225.

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Winand, Lea, Dustin Joshua Vollmann, Jacqueline Hentschel, and Markus Nett. "Characterization of a Solvent-Tolerant Amidohydrolase Involved in Natural Product Heterocycle Formation." Catalysts 11, no. 8 (2021): 892. http://dx.doi.org/10.3390/catal11080892.

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Heterocycles are important building blocks in pharmaceutical drugs and their enzymatic synthesis is attracting increasing interest. In recent years, various enzymes of the amidohydrolase superfamily were reported to catalyze heterocycle-forming condensation reactions. One of these enzymes, MxcM, is biochemically and kinetically characterized in this study. MxcM generates an imidazoline moiety in the biosynthesis of the natural product pseudochelin A, which features potent anti-inflammatory properties. The enzyme shows maximal activity at 50 °C and pH 10 as well as a kcat/Km value of 22,932 s−1
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Cogan, Dillon P., Graham A. Hudson, Zhengan Zhang, et al. "Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis." Proceedings of the National Academy of Sciences 114, no. 49 (2017): 12928–33. http://dx.doi.org/10.1073/pnas.1716035114.

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The [4+2] cycloaddition reaction is an enabling transformation in modern synthetic organic chemistry, but there are only limited examples of dedicated natural enzymes that can catalyze this transformation. Thiopeptides (or more formally thiazolyl peptides) are a class of thiazole-containing, highly modified, macrocyclic secondary metabolites made from ribosomally synthesized precursor peptides. The characteristic feature of these natural products is a six-membered nitrogenous heterocycle that is assembled via a formal [4+2] cycloaddition between two dehydroalanine (Dha) residues. This heteroan
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Gibson, Colin. "Preface." Pure and Applied Chemistry 84, no. 7 (2012): iv. http://dx.doi.org/10.1351/pac20128407iv.

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It is a privilege to act as the conference editor for this issue of Pure and Applied Chemistry. The 11 papers in this issue constitute selected contributions from the 23rd International Congress on Heterocyclic Chemistry, which was held in the Scottish Exhibition and Conference Centre in Glasgow between 31 July and 4 August 2011. This congress of the International Society of Heterocyclic Chemistry was attended by over 400 participants from over 40 different countries.The conference papers in this issue arise from plenary (Profs. Magid Abou-Gharbia and David O’Hagan), invited (Profs. Janine Cos
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Grünewald, Jan, and Mohamed A. Marahiel. "Chemoenzymatic and Template-Directed Synthesis of Bioactive Macrocyclic Peptides." Microbiology and Molecular Biology Reviews 70, no. 1 (2006): 121–46. http://dx.doi.org/10.1128/mmbr.70.1.121-146.2006.

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SUMMARY Non-ribosomally synthesized peptides have compelling biological activities ranging from antimicrobial to immunosuppressive and from cytostatic to antitumor. The broad spectrum of applications in modern medicine is reflected in the great structural diversity of these natural products. They contain unique building blocks, such as d-amino acids, fatty acids, sugar moieties, and heterocyclic elements, as well as halogenated, methylated, and formylated residues. In the past decades, significant progress has been made toward the understanding of the biosynthesis of these secondary metabolite
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Hemmerling, Franziska, and Frank Hahn. "Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides." Beilstein Journal of Organic Chemistry 12 (July 20, 2016): 1512–50. http://dx.doi.org/10.3762/bjoc.12.148.

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This review highlights the biosynthesis of heterocycles in polyketide natural products with a focus on oxygen and nitrogen-containing heterocycles with ring sizes between 3 and 6 atoms. Heterocycles are abundant structural elements of natural products from all classes and they often contribute significantly to their biological activity. Progress in recent years has led to a much better understanding of their biosynthesis. In this context, plenty of novel enzymology has been discovered, suggesting that these pathways are an attractive target for future studies.
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Nash, Robert J. "Natural product biosynthesis." New Phytologist 155, no. 1 (2002): 7. http://dx.doi.org/10.1046/j.1469-8137.2002.00449_4.x.

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Frankel, Brenda A., and Dewey G. McCafferty. "Profiling Natural Product Biosynthesis." Chemistry & Biology 11, no. 3 (2004): 290–91. http://dx.doi.org/10.1016/j.chembiol.2004.03.007.

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Tibrewal, Nidhi, and Yi Tang. "Biocatalysts for Natural Product Biosynthesis." Annual Review of Chemical and Biomolecular Engineering 5, no. 1 (2014): 347–66. http://dx.doi.org/10.1146/annurev-chembioeng-060713-040008.

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Liu, Hung-wen, and Tadhg Begley. "Natural product biosynthesis—a Renaissance." Current Opinion in Chemical Biology 17, no. 4 (2013): 529–31. http://dx.doi.org/10.1016/j.cbpa.2013.07.005.

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Dissertations / Theses on the topic "Heterocyclic natural product biosynthesis"

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Chan, Karen Hoi-Lam. "A genomics-led approach to deciphering heterocyclic natural product biosynthesis." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/284916.

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Heterocycles play an important role in many biological processes and are widespread among natural products. Oxazole-containing natural products possess a broad range of bioactivities and are of great interest in the pharmaceutical and agrochemical industries. Herein, the biosynthetic routes to the oxazole-containing phthoxazolins and the bis(benzoxaozle) AJI9561, were investigated. Phthoxazolins A-D are a group of oxazole trienes produced by a polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) pathway in Streptomyces sp. KO-7888 and Streptomyces sp. OM-5714. The phthoxazolin pathwa
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Tang, Lam T. "New routes to heterocyclic product families." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365338.

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Foley, Timothy Leyden. "Manipulating posttranslational modification in natural product biosynthesis." Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p3390676.

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Thesis (Ph. D.)--University of California, San Diego, 2010.<br>Title from first page of PDF file (viewed Feb. 19, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 234-254).
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Heberlig, Graham William. "Harnessing Natural Product Biosynthesis to Access Macrocycles." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39260.

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Macrocyclic natural products are conformationally restricted molecules that often have improved ability to bind with high affinity and selectivity on a target. Within macrocycle chemistry, macrolactone formation is a particularly challenging transformation and has spurred the development of highly diverse synthetic strategies. A key strategy that is missing is a chemoenzymatic approach to this challenge, and the logical place to look for such a catalyst is the thioesterases (TEs) from the biosynthetic pathways that generate these molecules in Nature. These TEs are α/β-hydrolases containing an
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Leadbeater, Claire. "Natural product biosynthesis : mechanistic and enzymatic studies." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/15194.

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The gene encoding the <I>E. coli</I> flavodoxin NADP<SUP>+</SUP> oxidoreductase (FLDR) has been overexpressed in <I>E. coli</I> and purified to homogeneity. The molecular mass of FLDR apoprotein was determined as 27648 Da. The midpoint reduction potentials of the oxidised/semiquinone and semiquinone/hydroquinone couples of FLDR (-308mV and -268mV, respectively) were measured using redox potentiometry. FLDR was fully characterised kinetically both by steady state and pre-steady state techniques. Arginines (R144, R174 and R184) in the proposed NADPH binding site of <I>E. coli</I> flavodoxin NADP
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Wang, Xiaoling. "Natural product discovery and biosynthesis from soil actinobacteria." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203796.

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New structurally diverse natural products can be discovered when carefully designed screening procedures have been applied and when a prolific organism from a different biological source is examined, such as, rare actinobacteria from an untapped environment. Chapter 3 describes the isolation and structure characterisation of eight compounds from the rare actinobacterum, Saccharothrix xinjiangensis (NRRL B-24321), including, two new 16-member macrolides, Tianchimycin A and B, respectively. OSMAC (One Strain - Many Compounds) is used to search bioactive compounds from the metabolic profile of S.
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Salem, Shaimaa Mohamed. "Biosynthesis of Marineosin, a Spiroaminal Undecylprodiginine Natural Product." PDXScholar, 2012. https://pdxscholar.library.pdx.edu/open_access_etds/936.

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Marineosins A and B are two spiroaminal-ring containing tripyrrole compounds isolated from the marine actinomycete, Streptomyces CNQ-617, and were found to possess potent and selective cytotoxic activity against leukemia and melanoma. Marineosins belong to the prodiginines class of natural products, examples of which are undecylprodiginine and streptorubin B. Unlike marineosins, prodiginines structures are characterized by the presence of fully conjugated tripyrrole nucleus linked to an alkyl chain (that lacks any oxygen). Cyclic prodiginines arise from an oxidative cyclization of the alkyl ch
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Fidan, Ozkan. "Exploring the Capacity of Bacteria for Natural Product Biosynthesis." DigitalCommons@USU, 2019. https://digitalcommons.usu.edu/etd/7510.

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This dissertation is focused on exploring the potential of bacteria for the biosynthesis of natural products with the purposes of generating novel natural product derivatives and of improving the titer of pharmaceutically important natural products. A wide variety of compounds from various sources have been historically used in the treatment and prevention of diseases. Natural products as a major source of new drugs are extensively explored due to their huge structural diversity and promising biological activities such as antimicrobial, anticancer, antifungal, antiviral and antioxidant propert
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Wee, Chorng Shin. "Theoretical studies of Diels-Alder reactions in natural product biosynthesis /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202008%20WEE.

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Samborskyy, Markiyan. "Genomic approaches to understanding natural product biosynthesis in the actinomycete Saccharopolyspora erythraea." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608432.

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Books on the topic "Heterocyclic natural product biosynthesis"

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service), ScienceDirect (Online, ed. Complex enzymes in microbial natural product biosynthesis: Polyketides, aminocoumarins and carbohydrates. Academic, 2009.

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service), ScienceDirect (Online, ed. Complex enzymes in microbial natural product biosynthesis: Overview articles and peptides. Elsevier, 2009.

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Pearson, William H. Advances in Heterocyclic Natural Product Synthesis. Jai Pr, 1997.

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Pearson, William H. Advances in Heterocyclic Natural Product Synthesis. JAI Press, 1990.

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Pearson, William H. Advances in Heterocyclic Natural Product Synthesis. Jai Pr, 1991.

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Natural Product Biosynthesis by Microorganisms and Plants Part C. Elsevier Science & Technology Books, 2012.

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Natural Product Biosynthesis by Microorganisms and Plants, Part A. Elsevier Science & Technology Books, 2012.

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Tang, Yi, and Christopher T. Walsh. Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery. Royal Society of Chemistry, The, 2017.

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Hopwood, David A. Natural Product Biosynthesis by Microorganisms and Plants Part B. Elsevier Science & Technology Books, 2012.

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Natural Product Biosynthesis by Microorganisms and Plants, Part C. Elsevier, 2012. http://dx.doi.org/10.1016/c2012-0-03033-5.

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Book chapters on the topic "Heterocyclic natural product biosynthesis"

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Floss, Heinz G., Paul J. Keller, Quang Le Van, Peter Nielsen, Gerhard Neuberger, and Adelbert Bacher. "Biosynthesis of Riboflavin." In Natural Product Chemistry. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71425-2_6.

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Stipanovic, Robert D. "Natural Product Biosynthesis Via the Diels-Alder Reaction." In Secondary-Metabolite Biosynthesis and Metabolism. Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3012-1_22.

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Todd Hovey, M., Ashley A. Jaworski, and Karl A. Scheidt. "N-Heterocyclic Carbene Catalysis in Natural Product and Complex Target Synthesis." In N-Heterocyclic Carbenes in Organocatalysis. Wiley-VCH Verlag GmbH & Co. KGaA, 2019. http://dx.doi.org/10.1002/9783527809042.ch12.

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Bugg, Timothy D. H. "Nucleoside Natural Product Antibiotics Targetting Microbial Cell Wall Biosynthesis." In Topics in Medicinal Chemistry. Springer International Publishing, 2017. http://dx.doi.org/10.1007/7355_2017_4.

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Udwary, Daniel W. "Chapter 10. Natural Product Combinatorial Biosynthesis: Promises and Realities." In RSC Biomolecular Sciences. Royal Society of Chemistry, 2009. http://dx.doi.org/10.1039/9781847559890-00299.

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Twigg, Frederick, David Skyrud, Jeffrey Li, and Wenjun Zhang. "Chapter 10. Engineering Enzymes for Natural Product Biosynthesis and Diversification." In Catalysis Series. Royal Society of Chemistry, 2018. http://dx.doi.org/10.1039/9781788010450-00261.

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Hsieh, Po-Hung, and Jian Liu. "Complex Natural Product Heparin: Biosynthesis, Biology, and Application via Synthetic Heparins." In The Science and Regulations of Naturally Derived Complex Drugs. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11751-1_3.

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Zhang, Haoran, Lei Fang, Marcia S. Osburne, and Blaine A. Pfeifer. "The Continuing Development of E. coli as a Heterologous Host for Complex Natural Product Biosynthesis." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3375-4_8.

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Christensen, Søren Brøgger, Henrik Toft Simonsen, Nikolai Engedal, et al. "From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development." In Progress in the Chemistry of Organic Natural Products 115. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-64853-4_2.

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Steele, Andrew D., Edward Kalkreuter, Guohui Pan, Song Meng, and Ben Shen. "Hybrid Peptide–Polyketide Natural Product Biosynthesis." In Comprehensive Natural Products III. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-409547-2.14669-4.

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Conference papers on the topic "Heterocyclic natural product biosynthesis"

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VAN DER DONK, WILFRED A. "NATURAL PRODUCT BIOSYNTHESIS IN THE GENOMIC AGE." In 23rd International Solvay Conference on Chemistry. WORLD SCIENTIFIC, 2014. http://dx.doi.org/10.1142/9789814603836_0002.

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Amarandi, Roxana-Maria, Maria-Cristina Al-Matarneh, Lacramioara Popovici, et al. "Pyrrolo-fused heterocyclic derivatives: design, synthesis and anticancer evaluation." In New frontiers in natural product chemistry, scientific seminar with international participation. Institute of Chemistry, 2021. http://dx.doi.org/10.19261/nfnpc.2021.ab17.

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Lipko, Agata, Adam Jozwiak, Magdalena Kania, et al. "Biochemical tools to monitor isoprenoid biosynthesis – the case of polyprenol and dolichol." In New frontiers in natural product chemistry, scientific seminar with international participation. Institute of Chemistry, 2021. http://dx.doi.org/10.19261/nfnpc.2021.ab04.

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Nassar, S., B. Liu, and L. Beerhues. "Polyketide-related biosynthesis of plant anthranoids." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399796.

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Wungsintaweekul, J., N. Perstwong, S. Limsuwanchote, and N. Keawpradub. "Sodium nitroprusside triggers mitragynine biosynthesis in Kratom." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399801.

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Lee, KS, SI Kim, BJ Seong, et al. "Fuctuation in active component biosynthesis in ginseng sprouts according to cultivated period." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400148.

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Ștefan, G.-A., M.-M. Zamfirache, and LD Gorgan. "Expression profile of three genes involved in terpene biosynthesis in Lavandula angustifolia cultivars." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399781.

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Tropper, M., S. Höhn, J. Munkert, and W. Kreis. "BAHD-like malonyltransferase genes from Digitalis lanata and Arabidopsis thaliana and their putative role in cardenolide biosynthesis." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399788.

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Reports on the topic "Heterocyclic natural product biosynthesis"

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Salem, Shaimaa. Biosynthesis of Marineosin, a Spiroaminal Undecylprodiginine Natural Product. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.936.

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