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Dissertations / Theses on the topic 'Heterocyclic natural product biosynthesis'

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Published: 4 June 2021

Last updated: 8 February 2022

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1

Chan, Karen Hoi-Lam. "A genomics-led approach to deciphering heterocyclic natural product biosynthesis." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/284916.

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Heterocycles play an important role in many biological processes and are widespread among natural products. Oxazole-containing natural products possess a broad range of bioactivities and are of great interest in the pharmaceutical and agrochemical industries. Herein, the biosynthetic routes to the oxazole-containing phthoxazolins and the bis(benzoxaozle) AJI9561, were investigated. Phthoxazolins A-D are a group of oxazole trienes produced by a polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) pathway in Streptomyces sp. KO-7888 and Streptomyces sp. OM-5714. The phthoxazolin pathwa

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2

Tang, Lam T. "New routes to heterocyclic product families." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365338.

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3

Foley, Timothy Leyden. "Manipulating posttranslational modification in natural product biosynthesis." Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p3390676.

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Thesis (Ph. D.)--University of California, San Diego, 2010.<br>Title from first page of PDF file (viewed Feb. 19, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 234-254).

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4

Heberlig, Graham William. "Harnessing Natural Product Biosynthesis to Access Macrocycles." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39260.

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Macrocyclic natural products are conformationally restricted molecules that often have improved ability to bind with high affinity and selectivity on a target. Within macrocycle chemistry, macrolactone formation is a particularly challenging transformation and has spurred the development of highly diverse synthetic strategies. A key strategy that is missing is a chemoenzymatic approach to this challenge, and the logical place to look for such a catalyst is the thioesterases (TEs) from the biosynthetic pathways that generate these molecules in Nature. These TEs are α/β-hydrolases containing an

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5

Leadbeater, Claire. "Natural product biosynthesis : mechanistic and enzymatic studies." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/15194.

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The gene encoding the <I>E. coli</I> flavodoxin NADP<SUP>+</SUP> oxidoreductase (FLDR) has been overexpressed in <I>E. coli</I> and purified to homogeneity. The molecular mass of FLDR apoprotein was determined as 27648 Da. The midpoint reduction potentials of the oxidised/semiquinone and semiquinone/hydroquinone couples of FLDR (-308mV and -268mV, respectively) were measured using redox potentiometry. FLDR was fully characterised kinetically both by steady state and pre-steady state techniques. Arginines (R144, R174 and R184) in the proposed NADPH binding site of <I>E. coli</I> flavodoxin NADP

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Wang, Xiaoling. "Natural product discovery and biosynthesis from soil actinobacteria." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203796.

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New structurally diverse natural products can be discovered when carefully designed screening procedures have been applied and when a prolific organism from a different biological source is examined, such as, rare actinobacteria from an untapped environment. Chapter 3 describes the isolation and structure characterisation of eight compounds from the rare actinobacterum, Saccharothrix xinjiangensis (NRRL B-24321), including, two new 16-member macrolides, Tianchimycin A and B, respectively. OSMAC (One Strain - Many Compounds) is used to search bioactive compounds from the metabolic profile of S.

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7

Salem, Shaimaa Mohamed. "Biosynthesis of Marineosin, a Spiroaminal Undecylprodiginine Natural Product." PDXScholar, 2012. https://pdxscholar.library.pdx.edu/open_access_etds/936.

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Marineosins A and B are two spiroaminal-ring containing tripyrrole compounds isolated from the marine actinomycete, Streptomyces CNQ-617, and were found to possess potent and selective cytotoxic activity against leukemia and melanoma. Marineosins belong to the prodiginines class of natural products, examples of which are undecylprodiginine and streptorubin B. Unlike marineosins, prodiginines structures are characterized by the presence of fully conjugated tripyrrole nucleus linked to an alkyl chain (that lacks any oxygen). Cyclic prodiginines arise from an oxidative cyclization of the alkyl ch

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8

Fidan, Ozkan. "Exploring the Capacity of Bacteria for Natural Product Biosynthesis." DigitalCommons@USU, 2019. https://digitalcommons.usu.edu/etd/7510.

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This dissertation is focused on exploring the potential of bacteria for the biosynthesis of natural products with the purposes of generating novel natural product derivatives and of improving the titer of pharmaceutically important natural products. A wide variety of compounds from various sources have been historically used in the treatment and prevention of diseases. Natural products as a major source of new drugs are extensively explored due to their huge structural diversity and promising biological activities such as antimicrobial, anticancer, antifungal, antiviral and antioxidant propert

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9

Wee, Chorng Shin. "Theoretical studies of Diels-Alder reactions in natural product biosynthesis /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202008%20WEE.

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10

Samborskyy, Markiyan. "Genomic approaches to understanding natural product biosynthesis in the actinomycete Saccharopolyspora erythraea." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608432.

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11

Bernhardt, Peter Ph D. Massachusetts Institute of Technology. "Exploiting alkaloid biosynthesis in Madagascar periwinkle to obtain natural product derivatives and new biocatalysts." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/58384.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2010.<br>Cataloged from PDF version of thesis. Vita.<br>Includes bibliographical references.<br>Plant alkaloid biosynthesis produces many natural products with medicinal value. For example, vinblastine and vincristine from Catharanthus roseus monoterpene indole alkaloid biosynthesis, and camptothecin derivatives from Ophiorrhiza pumila quinoline alkaloid biosynthesis, are anticancer agents currently used in the clinic. Strictosidine synthase is a key enzyme in the biosynthesis of these medicinal natural products, but i

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Niblock, Helen Sarah. "Synthesis of the C(1)-C(9) fragment of disorazole C1 and novel heterocyclic analogues." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6251.

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A highly convergent strategy for the synthesis of the antitubulin polyketide disorazole C1 is proposed based around the alkyne precursor I, featuring a novel Evans-Tishchenko/ring closing alkyne metathesis approach. Due to the inherent symmetry of the molecule this retrosynthesis leads to two fragments: a β- hydroxyketone II and the oxazole C(1)-(9) fragment III. A review of previous syntheses of disorazole C1 and established structure activity relationships (SARs) highlights a gap in current knowledge relating to the role of the oxazole in tubulin binding. Therefore, the focus of this researc

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13

Huo, Liujie [Verfasser], and Rolf [Akademischer Betreuer] Müller. "Synthetic biotechnology to study and engineer natural product biosynthesis in actinomycetes / Liujie Huo. Betreuer: Rolf Müller." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2014. http://d-nb.info/105405469X/34.

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14

Mir, Mohseni Mahsa [Verfasser]. "Analysis of the natural product biosynthesis in gliding bacteria using in vitro assays / Mahsa Mir Mohseni." Bonn : Universitäts- und Landesbibliothek Bonn, 2017. http://d-nb.info/115077780X/34.

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15

Grell, Tsehai A. J. (Tsehai Ariane Julien). "Structural studies of S-adenosyl-L-methionine radical enzymes involved in tRNA and natural product biosynthesis." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/118265.

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Thesis: Ph. D. in Biological Chemistry, Massachusetts Institute of Technology, Department of Chemistry, 2018.<br>Cataloged from PDF version of thesis. Vita.<br>Includes bibliographical references.<br>Members of the S-adenosyl-L-methionine (AdoMet) radical enzyme superfamily catalyze a myriad of diverse and challenging biotransformations using a [4Fe-4S] cluster and a molecule of AdoMet to initiate radical. In this thesis, we used a combination of crystallographic and biochemical methods to identify the use of covalent catalysis and polar reactions in two AdoMet radical enzymes that catalyze th

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Uria, Agustinus Robert [Verfasser]. "Investigating Natural Product Biosynthesis in Uncultivated Symbiotic Bacteria of the Marine Sponge Theonella swinhoei / Agustinus Robert Uria." Bonn : Universitäts- und Landesbibliothek Bonn, 2013. http://d-nb.info/104809149X/34.

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Wirz, Monica Hélène. "Characterizing the Macrocyclization Activity of Fungal Polyketide Synthase Thioesterases." Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20551.

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Fungal polyketides are a diverse class of natural products that possess many pharmacological properties, including anticancer properties. These properties are evident in the resorcylic acid lactones, a family of polyketides, including zearalenone and radicicol, which shows potent inhibition of tumour cell growth. The key step in the biosynthesis of these lactones is macrocyclization of a linear carboxylic acid into the macrolactone. This reaction is catalyzed by a polyketide synthase (PKS) thioesterase enzyme. Bacterial PKS thioesterases (TEs) have been extensively studied and their substrate

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18

Krug, Daniel [Verfasser], and Rolf [Akademischer Betreuer] Müller. "Natural product biosynthesis in myxobacteria : studies on enzymatic versatility and secondary metabolite diversity / Daniel Krug. Betreuer: Rolf Müller." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2009. http://d-nb.info/1049838092/34.

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Napan, Kandy L. "Investigation of the Tailoring Steps in Pradimicin Biosynthesis." DigitalCommons@USU, 2016. https://digitalcommons.usu.edu/etd/4730.

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The actinobacteria Actinomadura hibisca synthesizes the natural products pradimicin A-C through a type II polyketide biosynthetic pathway. Eight tailoring enzymes in pradimicin biosynthesis have been investigated in this work, including PdmJ, PdmW, PdmN, PdmT, PdmO, PdmS, PdmQ and PdmF. PdmJ and PdmW were characterized as cytochrome P450 hydroxylases that catalyze the incorporation of two hydroxyl groups at C-5 and C-6, respectively. These enzymes worked synergistically and their co-expression significantly improved the efficiency of the hydroxylation steps. PdmN is an amino acid ligase that a

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Sturm, Noé. "Characterization of natural product biological imprints for computer-aided drug design applications." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF059/document.

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La comparaison de site peut-elle vérifier l’hypothèse: «Les origines biosynthétiques des produits naturels leurs confèrent des activités biologiques»? Pour répondre à cette question, nous avons développé un outil modélisant les propriétés accessibles au solvant des sites de liaison. La méthode a montré des aspects intéressants, mais elle souffre d’une sensibilité aux coordonnées atomiques. Cependant, des méthodes existantes nous ont permis de prouver que l’hypothèse est valide pour la famille des flavonoïdes. Afin d’étendre l’étude, nous avons développé un procédé automatique capable de recher

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Yazicioglu, Emre Yusuf. "Transformation Of Cyclohexanone Derivatives To Bicyclic Furan And Pyrrole Derivatives." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/12605269/index.pdf.

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Tetrahydrobenzofurans and tetrahydroindoles are two very valuable classes of substances which have wide usage area<br>either as starting materials for drug substances or many other compounds which have fused heterocyclic rings in their structures and pharmacophore for many complex natural products<br>syntheses of derivatives of these compounds with different substitution patterns, is an exciting challenge for many scientists. Benzofuran and tetrahydroindole derivatives, which are potent bioactive substances, are synthesized from various cyclohexanone derivatives that are allylated by Stork-ena

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22

Wyszynski, Filip Jan. "Dissecting tunicamycin biosynthesis : a potent carbohydrate processing enzyme inhibitor." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:3a7a509d-dba0-4d5b-9a39-a883c872d758.

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Tunicamycin nucleoside antibiotics were the first known to target the formation of peptidoglycan precursor lipid I in bacterial cell wall biosynthesis. They have also been used extensively as inhibitors of protein N-glycosylation in eukaryotes, blocking the biogenesis of early intermediate dolichyl-pyrophosphoryl-N-acetylglucosamine. Despite their unusual structures and useful biological properties, little is known about their biosynthesis. Elucidating the metabolic pathway of tunicamycins and gaining an understanding of the enzymes involved in key bond forming processes would not only be of g

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23

Wang, Ting. "Studies on Natural Products Phorboxazole A, Cephalosporolide E, F and Thuggacin C." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1316443941.

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24

Pan, Xinli [Verfasser], Dirk [Gutachter] Hoffmeister, Markus [Gutachter] Nett, and Timo H. J. [Gutachter] Niedermeyer. "Natural product biosynthesis in the genus Herpetosiphon : a genomics and chemistry-guided evaluation / Xinli Pan ; Gutachter: Dirk Hoffmeister, Markus Nett, Timo H. J. Niedermeyer." Jena : Friedrich-Schiller-Universität Jena, 2018. http://d-nb.info/1170396119/34.

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Bunn, Brittney Michalle. "Unraveling Genetically Encoded Pathways Leading to Bioactive Metabolites in Group V Cyanobacteria." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1448271831.

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26

Lin, Jun [Verfasser], Axel A. [Gutachter] Brakhage, Miriam [Gutachter] Rosenbaum, and Oskar [Gutachter] Zelder. "Development of a user-friendly heterologous expression system and its applications for natural product biosynthesis / Jun Lin ; Gutachter: Axel. A. Brakhage, Miriam Rosenbaum, Oskar Zelder." Jena : Friedrich-Schiller-Universität Jena, 2020. http://d-nb.info/1225397413/34.

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27

Xu, Fuchao. "Identification and Engineering of Nonribosomal Peptide Biosynthetic Systems." DigitalCommons@USU, 2018. https://digitalcommons.usu.edu/etd/7382.

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This research focuses on the understanding and engineering of nonribosomal peptide biosynthetic pathways in Streptomyces coelicolor CH999, Escherichia coli BAP1 and Saccharomyces cerevisiae BJ5464-NpgA. The biosynthetic systems of indigoidine from bacteria and beauvericin/bassianolide from fungi were studied in this research. The production of these valuble products was significantly increased by enhancing their synthetic pathway with metabolic engineering approaches. Indigoidine is a bacterial natural product with antioxidant and antimicrobial activities. Its bright blue color resembles the i

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Elbert, Bryony L. "The synthesis and applications of cyclic alkenylsiloxanes." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:a332365e-22f2-4449-b517-3fd8a62ea8a3.

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This thesis describes the development of robust methodology to access cyclic alkenylsiloxanes, and their subsequent application in Hiyama-Denmark cross couplings. An early chapter shows the identification of Lindlar reduction conditions capable of generating cyclic alkenylsiloxanes from alkynylsiloxanes in high yields. The use of such species in Hiyama-Denmark cross coupling is then examined, with particular emphasis on the development of fluoride-free conditions, previously unreported for this class of organosilane. A ring-size dependent orthogonality is revealed, where 5-membered cyclic alke

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Heaviside, Elizabeth Anne. "Analogues of antibacterial natural products." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:6b5bd771-515b-49d0-8ec9-cee115d3aebf.

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Analogues of Antibacterial Natural Products Elizabeth Anne Heaviside, St Catherine’s College, University of Oxford DPhil Thesis, Trinity Term 2012 This thesis is concerned with the synthesis and biological evaluation of structural mimics for the natural products 16-methyloxazolomycin and lemonomycin which display potent biological activity including antibacterial and antitumour activity. Chapter 1 explores methods and approaches to the discovery of new antibacterial drugs and the challenges faced in this respect. It also gives an overview of the properties of the natural products investigated

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Alqahtani, Norah Faihan. "Synergizing Microbial Culturing, Whole Genome Sequencing, Asymmetric Synthesis and Tandem MS for Reconstruction of Polyketide and Alkaloid Natural Product Biosynthesis in Marine Actinomycete Nocardiopsis sp CMB- M0232." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1421167765.

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Docherty, Paul Henry. "Diastereocontrolled synthesis of hetero- and carbocycles via manganese(III) and copper(II) : towards a novel prostaglandin total synthesis." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:6ca5556a-3d2d-454a-abbd-0a3a269c5724.

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The prostaglandins are a unique family of natural products found in all mammalian life, including humans. Their biological significance is profound, and they are responsible for a vast array of bodily functions. This importance, coupled with their low concentration in vivo, has made them attractive targets for total chemical synthesis. The work herein describes synthetic efforts towards their synthesis using an oxidative radical cyclisation to construct the key [3.3.0]-bridged bicyclic lactone, from which the prostaglandin skeleton may be derived. Key to this was the development of manganese(I

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Brown, Dustin Paul. "TARGET-DIRECTED BIOSYNTHETIC EVOLUTION: REDIRECTING PLANT EVOLUTION TO GENOMICALLY OPTIMIZE A PLANT’S PHARMACOLOGICAL PROFILE." UKnowledge, 2015. http://uknowledge.uky.edu/neurobio_etds/13.

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The dissertation describes a novel method for plant drug discovery based on mutation and selection of plant cells. Despite the industry focus on chemical synthesis, plants remain a source of potent and complex bioactive metabolites. Many of these have evolved as defensive compounds targeted on key proteins in the CNS of herbivorous insects, for example the insect dopamine transporter (DAT). Because of homology with the human DAT protein some of these metabolites have high abuse potential, but others may be valuable in treating drug dependence. This dissertation redirects the evolution of a nat

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Wang, Hua. "Semi-synthesis and biological evaluations of tunicamycin lipid analogues and investigation of the tunicamycin biosynthetic pathway." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:05c43287-9f84-45f4-8db4-0fb6c2763816.

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Tunicamycins are potent antimicrobial agents but are also toxic to mammalian cells, which render them clinically impractical to use to treat infectious diseases. Instead, they have been used extensively as biochemical tools to study the N-linked glycosylation of proteins. However, despite such a routine application, their inhibitory mechanisms are still not clear. The central objective of this thesis was to develop novel tunicamycin analogues that are non-toxic to eukaryotic cells that could serve as potential antimicrobial drug candidates. We hypothesised that if we retain the lipid character

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Westley, Chantel Barbara, and chantel westley@flinders edu au. "The distribution, biosynthetic origin and functional significance of Tyrian purple precursors in the Australian muricid Dicathais orbita (Neogastropoda: Muricidae)." Flinders University. Biological Sciences, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20090414.153942.

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Information on the biosynthetic origin and functional advantage of marine mollusc natural products is not only essential to our understanding of chemical ecology, but to the development and responsible production of therapeutic agents. As demonstrating in situ activity is methodologically hindered, functions inferred by in vitro activity have been assumed for many secondary metabolites. The anatomical and ontogenetic distribution of natural products can not only provide information on the biosynthesis and storage of metabolites, but identify selective pressures likely to affect survivorship at

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Shao, Zengyi. "Enabling natural product biosynthesis with novel synthetic biology tools /." 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3363089.

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Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.<br>Source: Dissertation Abstracts International, Volume: 70-06, Section: B, page: 3662. Adviser: Huimin Zhao. Includes bibliographical references. Available on microfilm from Pro Quest Information and Learning.

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Hus, Ning-Shian, та 許甯翔. "Biosynthesis Study for β-methylphenylalnine In the Natural Product: mannopeptimycins". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/64067766584061181112.

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碩士<br>國立臺灣海洋大學<br>食品科學系<br>95<br>A dramatic increase in the incidence of infections owing to multiple drug resistance in particular from Gram-positive bacteria is now a serious public health problem world wide. It was reported that over 70% bacteria have existed drug resistance to the antibiotics now often used. Mannopeptimycins are produced by Streptomyces hygroscopicus NRRL 30439. It represents a new class of lipoglycopeptide antibiotics with exceptional in vitro and in vivo antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin- resistant enteroco

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Kelly, Gilbert Thomson. "Probing the Biosynthesis and Mode of Action of Azinomycin B." 2009. http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-820.

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Since the isolation of azinomycins A and B in 1954 from the soil bacterium, Streptomyces sahachiroi, these natural products have been synthetic targets. Both compounds exhibit in vitro cytotoxic activity at submicromolar levels and demonstrate anti-tumor activities comparable to that of mitomycin C in vivo. Unique to this class of natural products is the presence of an aziridine [1,2-a] pyrrolidine ring system. Coupled with an epoxide moiety, these structural functionalities impart the ability to form interstrand cross-links with DNA via the electrophilic C10 and C21 carbons of azinomycin and

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Foulke-Abel, Jennifer. "Natural Product Biosynthesis: Friend or Foe? From Anti-tumor Agent to Disease Causation." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8705.

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Biosynthetic natural products are invaluable resources that have been gleaned from the environment for generations, and they play an essential role in drug development. Natural product biosynthesis also possesses the latent ability to affect biological systems adversely. This work implements recent advances in genomic, proteomic and microbiological technologies to understand further biosynthetic molecules that may influence progression of human disease. Azinomycin A and B are antitumor metabolites isolated from the terrestrial bacterium Streptomyces sahachiroi. The azinomycins possess an unusu

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Grochowski, Laura L. "Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis." Thesis, 2004. http://hdl.handle.net/1957/29916.

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Molecular genetic and enzymological techniques have been employed to study secondary metabolite biosynthesis. These investigations have focused on two projects: the cloning and heterologous expression of biosynthetic gene clusters from unculturable marine organisms and the characterization of individual enzymes involved in the biosynthesis of the antifungal agent blasticidin S. The marine environment is proving to be a valuable source of biologically active compounds, but problems associated with sustainable harvest, laboratory culture, and organic synthesis make obtaining sufficient quantitie

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Gerasyuto, Aleksey Igorevich. "Development of intramolecular aza- [3 + 3] annulation reaction and its applications in natural product synthesis." 2007. http://www.library.wisc.edu/databases/connect/dissertations.html.

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Enns, Jennifer Emily. "Regulation of Cholesterol Biosynthesis in Hepatocytes." 2010. http://hdl.handle.net/1993/4065.

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Hypercholesterolemia, a condition of high cholesterol levels in the circulation, poses a major risk for developing cardiovascular disease, such as atherosclerosis. A common method of reducing plasma cholesterol levels relies on the administration of drugs that limit cholesterol synthesis or uptake, many of which have undesirable side effects. Thus, some patients are turning to an alternative treatment, namely natural health products. Natural health products are often equally or even more effective at treating illness than synthetic drugs and may produce fewer side effects. The goal of this

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Dupuis, Stephanie. "Precursor-Directed Biosynthesis of Novel Jadomycins and Expansion of the Jadomycin Library." 2010. http://hdl.handle.net/10222/13053.

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Jadomycins are secondary metabolites produced by Streptomyces venezuelae ISP5230 VS1099 in response to conditions of stress such as heat or ethanol shock. They have been shown to exhibit antibiotic and anticancer activity. Unique structural features of the jadomycins include a rare 2,6-dideoxysugar, L-digitoxose, and an oxazolone ring with an amino acid component. Previous studies have revealed that jadomycin derivatives can be produced by altering the amino acid in S. venezuelae ISP5230 VS1099 culture media which becomes incorporated into the oxazolone ring. One jadomycin from a proteogen

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Lin, Mei-Yuan, and 林媺媛. "Virtual Screening for the Inhibitors of Squalene Synthase in Human Cholesterol Biosynthesis Pathway from Natural Product Database." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/06818526759749555249.

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碩士<br>國立東華大學<br>生命科學系<br>101<br>Cholesterol plays an important role in human body. However its accumulation may also cause many diseases. The currently available cholesterol-lowering drugs are all based on inhibiting the enzyme HMG-CoA reductase in the cholesterol biosynthesis pathway. However these medicines also inhibit the synthesis of other important factors at the lower stream and cause severe side effects. On the other hand, the key enzyme squalene synthase (SQS), locates at the downstream of these important factors, has become a better candidate to develop next generation drug to lower

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Choi, Sei Hyun. "Synthetic approaches to investigate the chemical mechanism in the biosynthesis of natural products." Thesis, 2012. http://hdl.handle.net/2152/26079.

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The study of the biosynthetic logic of natural products has established itself to be one of the more exciting areas of research and have become an important part of modern drug discovery and development efforts. Therefore, understanding the pathway and the chemical mechanism of the biosynthesis of natural products is important in that knowledge on these processes can be applied for combinatorial biosynthesis to generate new natural product derivatives with enhanced biological activities. In addition to the practical value, a lot of unprecedented chemical mechanisms can be found in the enzymes

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Mahmoud, Khaled Attia Shaaban. "Nafisamycin, Cyclisation Product of a New Enediyne Precursor, Highly Cytotoxic Mansouramycins, Karamomycins Possessing a Novel Heterocyclic Skeleton and Further Unusual Secondary Metabolites from Terrestrial and Marine Bacteria." Doctoral thesis, 2009. http://hdl.handle.net/11858/00-1735-0000-0006-ACC1-F.

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Coughlin, Jane M. "Hybrid peptide-polyketide natural product biosynthesis : resistance to the bleomycin family of antitumor antibiotics, beta-amino acid activating adenylation domains, and oxazolomycin polyketide synthases that requrie [sic] discrete aclytransferases for two distinct extender units /." 2008. http://www.library.wisc.edu/databases/connect/dissertations.html.

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