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Dissertations / Theses on the topic 'Heterodimerization'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 July 2024

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1

Doll, John M. 1976. "Catalysis of tubulin heterodimerization in vivo." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/32259.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.<br>Includes bibliographical references.<br>The heterodimerization of α- and β-tubulin represents a critical early step in microtubule morphogenesis. In vitro studies have defined a pathway that mediates the incorporation of monomeric tubulin polypeptides into heterodimer. The components of this pathway, tubulin cofactors, are dispensable for growth in Saccharomyces cerevisiae under laboratory conditions. Yet, these proteins are required for survival under conditions of stress or in the presence of a weakened tubuli

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2

Grant, Michael 1976. "The pharmacological and cellular effects of human somatostatin receptor homo- and heterodimerization /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115682.

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Somatostatin (SST) is a peptide hormone that was originally identified in the hypothalamus and subsequently found throughout the central nervous system and in various peripheral organs. Generally classified as an inhibitory factor, SST is secreted by endocrine, neuronal and immune cells and acts to regulate cell secretion, neurotransmission and cell proliferation. There are five receptor-subtypes known to engage SST, termed SSTR1-5, all belonging to the superfamily of G-protein coupled receptors (GPCRs). Within the past few years, there has been a prepondef8:llce of evidence to suggest the imp

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3

McVey, Mary. "An investigation of homo and heterodimerization of the human delta opioid receptor." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392648.

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4

Vincent, Karla Kristine. "Transactivation of Beta 2 Adrenergic Receptor by Bradykinin type 2 Receptor via heterodimerization." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/37117.

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Although a long standing convention maintained that G Protein Coupled Receptors (GPCRs) exist in the plasma membrane solely as monomers, substantial work over the last two decades has demonstrated that these ubiquitous receptors can and in many cases, preferentially, exist as homodimers, heterodimers, or higher order oligomers. Often, two GPCRs of the same class heterodimerize; it is less common for two GPCRs of different signaling pathways to interact. The work presented here studied the physical and functional interaction of two GPCRs from discrete classes, the Beta 2 Adrenergic Receptor

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5

Jing, Stanley M. "Cationic Cobalt(I)-Mediated Heterodimerizations: From Mechanistic Insights to Reaction Discovery." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1503302900762289.

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6

Bedi, Shimpi. "Identification of Novel Ligands and Structural Requirements for Heterodimerization of the Liver X Receptor Alpha." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1495630797912988.

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7

Unlu, Gokhan. "Optimization Of Fret Method To Detect Dimerization Of Dopamine D2 And Adenosine A2a Receptors In Live Cells." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613365/index.pdf.

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Recent studies demonstrate that there are several G-protein coupled receptors (GPCRs) that dimerize with other GPCRs and form heterodimers. Adenosine A2A-Dopamine D2 receptor interaction is one of the examples for GPCR heterodimerization. Both receptors bear critical roles in physiological processes. Adenosine A2A receptor has functions in neurotransmission, cardiovascular system and immune response. On the other hand, dopamine receptors are the key point of dopaminergic system, which controls the regulation of memory, attention, food intake, endocrine regulation, psychomotor activity and posi

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8

Akkuzu, Selin. "The Functional Assessment Of Fluorecently Tagged Adenosine A2a And Dopamine D2 Receptors And Qualitative Analysis Of Dimerization Of Adenosine A2a And Dopamine D2 Receptor By Using Fret." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615474/index.pdf.

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Recently, several studies have demonstrated that G protein coupled receptors exist as homo/heterodimers or oligomers. Adenosine A2A receptors and dopamine D2 receptors are present as both homo- and heterodimer. In the GABAergic striatopallidal neurons A2AR are co- localized with D2 receptors (D2R), and establish functional A2AR-D2R heteromers, which modulates dopaminergic activity. Due to be involved in physiological processes, these receptors bear critical roles. Dopamine receptors play critical role in dopaminergic pathways in regulation of memory, food intake and psychomotor activity, etc.

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9

Guigues, Adeline. "Interactions entre CCR5 et trois récepteurs couplés aux protéines G : EBI2, A2A et S1P1 : effets sur l'infection par le VIH-1, mécanismes d'action et perspectives thérapeutiques." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT048/document.

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Mon laboratoire d’accueil avait montré que la densité de CCR5 à la surface des cellules cibles du VIH détermine très fortement leur infectabilité par les souches virales R5, et que les signaux d’activation cellulaire induits par la fixation virale et transitant par CCR5 favorisent une infection productive des cellules primaires. L’hypothèse de notre travail était que d’autres récepteurs couplés aux protéines G (RCPG) exprimés dans les lymphocytes T CD4+ CCR5+ pourraient également influer sur le cycle de réplication des virus R5. Pour tester cette hypothèse, les RCPGs co-exprimés avec CCR5 dans

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10

Benleulmi-Chaachoua, Abla. "Etude des partenaires protéiques associés aux homodimères et aux hétérodimères des récepteurs couplés aux protéines G." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T018/document.

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La mélatonine est une neuro-hormone secrétée par la glande pinéale pour réguler les rythmes circadiens, le sommeil, la physiologie de la rétine, la reproduction saisonnière et diverses fonctions neuronales. La mélatonine exerce ses fonctions en se liant à deux récepteurs membranaires appelés MT1 et MT2 qui appartiennent à la famille des récepteurs couplés aux protéines G (RCPG). Les RCPG sont connus pour former des homo- et hétérodimères mais la pertinence physiologique de ces complexes reste à démontrer. Plusieurs études montrent que la fonction de ces complexes ne se limite pas à la régulati

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11

Bonaventura, Jordi. "Homòmers i heteròmers dels receptors D(2) de dopamina: implicacions funcionals a l'estriat." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/101095.

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Els receptors acoblats a proteïna G són la diana d'una gran part dels fàrmacs en ús i en desenvolupament. L'homomerització i l'heteromerització entre GPCR és un concepte cada cop més acceptat dins la comunitat científica. I de fet, els heteròmers entre alguns d'aquests receptors s'estan postulant com a dianes terapèutiques emergents, com és el cas dels heteròmers de receptors A(2A)-D(2) per al cas de la malaltia de Parkinson. Per tant, l'objectiu general d'aquesta tesi ha estat conèixer els mecanismes pels quals els lligands clàssics, nous lligands i altres receptors de la membrana plasmàtica

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12

Comoglio, Yannick. "Étude de la régulation et de la diversité combinatoire des canaux potassiques à deux domaines P de la sous famille TREK." Thesis, Université Côte d'Azur (ComUE), 2016. http://www.theses.fr/2016AZUR4089/document.

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Les canaux potassiques à deux domaines pore sont impliqués dans un grand nombre de mécanismes physiopathologiques. Lors de ma thèse je me suis intéressé à la sous famille TREK dont les membres, TREK-1, TREK-2 et TRAAK jouent un rôle dans la nociception, la dépression et la neuroprotection. Leur activité est finement régulée par des stimuli physicochimiques (Température, étirement, pH), pharmacologiques (anesthésiques volatils, fluxétine,…) et physiologiques (GPCR). Lors de ma thèse je me suis intéressé à deux nouveaux modes de régulation de ces canaux ainsi qu'à leur diversité combinatoire. To

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13

Comoglio, Yannick. "Étude de la régulation et de la diversité combinatoire des canaux potassiques à deux domaines P de la sous famille TREK." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2016. http://www.theses.fr/2016AZUR4089.

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Les canaux potassiques à deux domaines pore sont impliqués dans un grand nombre de mécanismes physiopathologiques. Lors de ma thèse je me suis intéressé à la sous famille TREK dont les membres, TREK-1, TREK-2 et TRAAK jouent un rôle dans la nociception, la dépression et la neuroprotection. Leur activité est finement régulée par des stimuli physicochimiques (Température, étirement, pH), pharmacologiques (anesthésiques volatils, fluxétine,…) et physiologiques (GPCR). Lors de ma thèse je me suis intéressé à deux nouveaux modes de régulation de ces canaux ainsi qu'à leur diversité combinatoire. To

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14

Fussner, Eden Margaret. "Heterodimerization and oligomerization of the BTB domain." 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=441983&T=F.

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15

Suthaus, Jan [Verfasser]. "Ligand-independent gp130-type receptor activation by forced homo- and heterodimerization / vorgelegt von Jan Suthaus." 2010. http://d-nb.info/100773826X/34.

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16

Holland, Patrick. "DRUGS, DIMERS, AND MUTATIONS: INVESTIGATING THE EFFECTS OF LIGANDS AND A ?2-ADRENERGIC POLYMORPHISM ON HOMO/HETERODIMERIZATION OF ?2-ADRENERGIC AND ANGIOTENSIN II TYPE 1 RECEPTORS." Thesis, 2012. http://hdl.handle.net/10222/15245.

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GPCRs are known to form dimeric structures, and this affects their pharmacological properties. The ?2AR and AT1aR are GPCRs that are involved the regulation of the adrenergic and renin-angiotensin systems. The ?2AR is polymorphic at position 164, affecting its responsiveness to adrenergic ligands. Both receptors have been shown to form dimers, but little is known on how dimerization affects their trafficking and signalling following ligand treatments. Plasma membrane localization, arrestin-2 recruitment, and G-protein interactions were determined between receptor dimers using molecular biologi

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17

Tsai, Wen-Yang, and 蔡文揚. "Study of antibody responses in dengue patients and the expression of precursor membrane protein of dengue virus and its involvement in heterodimerization and recombinant subviral particles formation." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/07920709583242913187.

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碩士<br>國立臺灣大學<br>微生物學研究所<br>95<br>Dengue viruses（DENV）are members of the family Flaviviridae. Among the 80 or so arthropod-borne flaviviruses, the four serotypes of DENV（DENV1, DENV2, DENV3, DENV4）cause the most important arboviral diseases in human, including the classic dengue fever（DF）and severe dengue hemorrhagic fever/dengue shock syndrome（DHF/DSS）. Infection by one serotype of DENV can provide life-long protection against that serotype, but not against other serotypes. Infection of DENV in mononuclear cells has been shown to be enhanced by the presence of non-neutralizing antibody or subo

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18

Liebick, Marcel. "Chemokine receptors CXCR4 and CCR5: Cell surface expression, signaling and modulation by β-arrestin 2". Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0022-5DD3-C.

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