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Journal articles on the topic 'Hexadentate chelation'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Melendez-Zamudio, Miguel, Kevina Chavda, and Michael A. Brook. "Chelating Silicone Dendrons: Trying to Impact Organisms by Disrupting Ions at Interfaces." Molecules 27, no. 6 (2022): 1869. http://dx.doi.org/10.3390/molecules27061869.

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The viability of pathogens at interfaces can be disrupted by the presence of (cationic) charge and chelating groups. We report on the synthesis of silicone dendrimers and linear polymers based on a motif of hexadentate ligands with the ability to capture and deliver metal ions. Mono-, di- or trialkoxysilanes are converted in G1 to analogous vinylsilicones and then, iteratively using the Piers-Rubinsztajn reaction and hydrosilylation, each vinyl group is transformed into a trivinyl cluster at G2. The thiol-ene reaction with cysteamine or 3-mercaptopropionic acid and the trivinyl cluster leads t

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2

Zhou, Tao, Robert C. Hider, and Xiaole Kong. "Mode of iron(iii) chelation by hexadentate hydroxypyridinones." Chemical Communications 51, no. 26 (2015): 5614–17. http://dx.doi.org/10.1039/c4cc10339d.

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Tripodal hexadentate hydroxypyridin-4-ones are increasingly utilised as iron(iii) and gallium(iii) ligands, their attachment to proteins being particularly useful for positron emission tomography (PET). A tripodal ligand NTA(BuHP)<sub>3</sub>, which is reported to form 1 : 1 iron(iii) and gallium(iii) complexes in aqueous, media forms 2 : 2 complexes under physiological conditions.

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3

Zhou, Tao, Xiao-Le Kong, and Robert C. Hider. "Synthesis and iron chelating properties of hydroxypyridinone and hydroxypyranone hexadentate ligands." Dalton Transactions 48, no. 10 (2019): 3459–66. http://dx.doi.org/10.1039/c8dt05014g.

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4

Devanur, Lakshmi D., Robert W. Evans, Patricia J. Evans, and Robert C. Hider. "Chelator-facilitated removal of iron from transferrin: relevance to combined chelation therapy." Biochemical Journal 409, no. 2 (2007): 439–47. http://dx.doi.org/10.1042/bj20070823.

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Current iron chelation therapy consists primarily of DFO (desferrioxamine), which has to be administered via intravenous infusion, together with deferiprone and deferasirox, which are orally-active chelators. These chelators, although effective at decreasing the iron load, are associated with a number of side effects. Grady suggested that the combined administration of a smaller bidentate chelator and a larger hexadentate chelator, such as DFO, would result in greater iron removal than either chelator alone [Grady, Bardoukas and Giardina (1998) Blood 92, 16b]. This in turn could lead to a decr

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5

Pramanik, Kausikisankar, Soma Karmakar, Suranjan Bhanja Choudhury, and Animesh Chakravorty. "Thioether-Coordinated Nickel Oxidation States. A NiIIIS2N4Family Incorporating Hexadentate Thioether−Azo−Oxime Chelation." Inorganic Chemistry 36, no. 16 (1997): 3562–64. http://dx.doi.org/10.1021/ic970009a.

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6

Porter, J., C. Borgna-Pignatti, M. Baccarani, et al. "Iron Chelation Efficiency of Deferasirox (Exjade®, ICL670) in Patients with Transfusional Hemosiderosis." Blood 106, no. 11 (2005): 2690. http://dx.doi.org/10.1182/blood.v106.11.2690.2690.

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Abstract Iron excretion can be calculated according to Angelucci et al (NEJM 2000). As applied to the novel oral iron chelator deferasirox (DSX), chelation efficiency can then be determined as the % iron excretion vs theoretical iron binding capacity of chelator dose: % efficiency = [iron excretion (mg/kg/day)/chelator dose (mg/kg/day)] x [374/56] x 2 x 100 (374 and 56 represent the molecular weights of DSX and iron; factor 2 accounts for the tridentate ligand). In a total of 325 patients with β-thalassemia (n=285) or rare anemias, such as MDS (n=13), DBA (n=14) or other anemias (n=13), includ

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7

Szigethy, Géza, and Kenneth N. Raymond. "Hexadentate Terephthalamide(bis-hydroxypyridinone) Ligands for Uranyl Chelation: Structural and Thermodynamic Consequences of Ligand Variation(1)." Journal of the American Chemical Society 133, no. 20 (2011): 7942–56. http://dx.doi.org/10.1021/ja201511u.

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8

Maclean, Kirsteen H., John L. Cleveland, and John B. Porter. "Cellular zinc content is a major determinant of iron chelator–induced apoptosis of thymocytes." Blood 98, no. 13 (2001): 3831–39. http://dx.doi.org/10.1182/blood.v98.13.3831.

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Abstract Desferrioxamine (DFO) and the hydroxypiridinone (HPO) deferiprone (CP20) chelate iron as well as other metals. These chelators are used clinically to treat iron overload, but they induce apoptosis in thymocytes. Thymocyte apoptosis is potentiated by zinc deficiency, suggesting that these iron chelators may induce apoptosis by depleting stores of zinc. Exposure of murine thymocytes to either DFO or deferiprone resulted in significant reductions in the labile intracellular zinc pool. Moreover, increasing intracellular zinc levels, by chronic zinc dietary supplementation to mice or in vi

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9

Link, G., A. Pinson, and C. Hershko. "Ability of the orally effective iron chelators dimethyl- and diethyl- hydroxypyrid-4-one and of deferoxamine to restore sarcolemmal thiolic enzyme activity in iron-loaded heart cells." Blood 83, no. 9 (1994): 2692–97. http://dx.doi.org/10.1182/blood.v83.9.2692.2692.

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Abstract In view of the profound functional and structural abnormalities shown in our previous studies in cultured, iron-loaded rat heart cells, we have examined the ability of the orally effective iron chelators dimethyl-3-hydroxypyrid-4-one (DMHP or L1) and diethyl-3-hydroxy-pyrid- 4-one (DEHP or CP94) and of deferoxamine (DF) to reverse the damage caused by iron loading to heart cell organelles. At a concentration of 1.0 mmol/L, all three iron chelators were equally efficient in removing iron and restoring the activity of the thiolic sarcolemmal enzymes 5′- nucleotidase and Na,K,ATPase. How

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10

Link, G., A. Pinson, and C. Hershko. "Ability of the orally effective iron chelators dimethyl- and diethyl- hydroxypyrid-4-one and of deferoxamine to restore sarcolemmal thiolic enzyme activity in iron-loaded heart cells." Blood 83, no. 9 (1994): 2692–97. http://dx.doi.org/10.1182/blood.v83.9.2692.bloodjournal8392692.

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In view of the profound functional and structural abnormalities shown in our previous studies in cultured, iron-loaded rat heart cells, we have examined the ability of the orally effective iron chelators dimethyl-3-hydroxypyrid-4-one (DMHP or L1) and diethyl-3-hydroxy-pyrid- 4-one (DEHP or CP94) and of deferoxamine (DF) to reverse the damage caused by iron loading to heart cell organelles. At a concentration of 1.0 mmol/L, all three iron chelators were equally efficient in removing iron and restoring the activity of the thiolic sarcolemmal enzymes 5′- nucleotidase and Na,K,ATPase. However, at

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11

Noguchi, Daisuke. "ANALYSIS OF SPECIALTIES OF CRYSTAL STRUCTURE FOR NON-CHELATE CONFORMATIONS OF ETHYLENE-DIAMINETETRAACETIC ACID AND ITS SALTS WITH ALKALI AND ALKALINE EARTH METALS." Ukrainian Chemistry Journal 88, no. 10 (2022): 55–69. http://dx.doi.org/10.33609/2708-129x.88.10.2022.55-69.

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In the present study, the crystal structures of non-chelating EDTA molecules and their non-chelation salts in a zwitterionic state, along with the EDTA-chelates of alkali and alkaline earth metals, were searched and overviewed. 25 non-chelating molecules of EDTA, and zwitterions of ethylenediammonium-diacetate diacetic acid HOOC-CH2-(-OOC-CH2-)NH+-CH2-CH2-NH+(-CH2-COO-)-CH2-COOH and their salts (ethylenediammonium-tetraacetic acid (HOOC-CH2-)2NH+-CH2-CH2-NH+(-CH2-COOH)2, ethylenediammonium-acetate triacetic acid (HOOC-CH2-)2NH+-CH2-CH2-NH+(-CH2-COO-)-CH2-COOH, and ethylenediammonium-tetraacet

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12

Woods, Joshua J., Ryan Unnerstall, Abbie Hasson та ін. "Stable Chelation of the Uranyl Ion by Acyclic Hexadentate Ligands: Potential Applications for ²³⁰U Targeted α-Therapy". Inorganic Chemistry 61, № 7 (2022): 3337–50. http://dx.doi.org/10.1021/acs.inorgchem.1c03972.

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13

Rajib, Lal De, and Kumar De Rajib. "Synthesis and structure of mixed metal Zn3Ni2 -complexes of tetradentate Schiff bases." Journal of Indian Chemical Society Vol. 91, Dec 2014 (2014): 2165–72. https://doi.org/10.5281/zenodo.5742305.

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Department of Chemistry, Inorganic Chemistry Section, Jadavpur University, Kolkata-700 032, India <em>E-mail </em>: rajiblal@hotmail.com <em>Manuscript received 13 January 2014, revised 26 June 2014, accepted 03 July 2014</em> The nickel(II) tetradentate Schiff base complexes, Ni(SALEN), Ni(S-BrSALEN), Ni(SALPN<sub>x</sub> ) and Ni(SALPN<sub>y</sub> ) underwent facile reactions with zinc perchlorate hexahydrate, Zn(ClO<sub>4</sub> )<sub>2</sub> .6H<sub>2</sub>O resulting in excellent complex formations. Compounds of formula [{ZnL}<sub>2</sub>Zn(H<sub>2</sub>O)<sub>2</sub> ](ClO<sub>4</sub> )<s

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14

Ibrahim, Riyam Baqer, and Suad Taha Saad. "Synthesis, Characterization and Breast Anti-cancer Activity of Iron(II), Cobalt(II), Nickel(II) and Copper(II) Complexes with a Hexadentate Schiff Base Ligand Derived from 2,5-Dihydroxy-1,4-benzoquinone with 5-Amino-2-methylphenol." Indonesian Journal of Chemistry 23, no. 6 (2023): 1676. http://dx.doi.org/10.22146/ijc.85611.

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The complexes of Fe(II), Co(II), Ni(II), and Cu(II) Schiff base ligand derived from 2,5-dihydroxy-1,4-benzoquinone and 5-amino-2-methylphenol were synthesized. The ligand was synthesized by the reaction between the mentioned ketone and amine in 1:2 molar ratio, respectively. The four metal complexes were synthesized by refluxing the ligand with the related metal(II) chloride salts. The synthesized compounds were characterized using FTIR spectroscopy, UV-visible, 1H-NMR, conductivity, atomic absorption, magnetic susceptibility, and thermogravimetric analysis. According to the results, the chela

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15

Zhou, Ying-Jun, Xiao-Le Kong, Jun-Pei Li, Yong-Min Ma, Robert C. Hider, and Tao Zhou. "Novel 3-hydroxypyridin-4-one hexadentate ligand-based polymeric iron chelator: synthesis, characterization and antimicrobial evaluation." MedChemComm 6, no. 9 (2015): 1620–25. http://dx.doi.org/10.1039/c5md00264h.

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A novel 3-hydroxypyridin-4-one hexadentate-based copolymeric iron chelator was prepared. The polymer was found to possess high iron affinity and appreciable inhibitory activity against both Gram-positive and Gram-negative bacteria.

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16

Choudhary, Neha, Kendall E. Barrett, Manja Kubeil, et al. "Metal ion size profoundly affects H3glyox chelate chemistry." RSC Advances 11, no. 26 (2021): 15663–74. http://dx.doi.org/10.1039/d1ra01793d.

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The bisoxine hexadentate chelating ligand, H<sub>3</sub>glyox was investigated for its affinity for Mn<sup>2+</sup>, Cu<sup>2+</sup> and Lu<sup>3+</sup> ions; all three metal ions are relevant with applications in nuclear medicine and medicinal inorganic chemistry.

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17

Bergeron, Raymond J., Jan Wiegand, and Gary M. Brittenham. "HBED: A Potential Alternative to Deferoxamine for Iron-Chelating Therapy." Blood 91, no. 4 (1998): 1446–52. http://dx.doi.org/10.1182/blood.v91.4.1446.

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Abstract To examine the potential clinical usefulness of the hexadentate phenolic aminocarboxylate iron chelatorN,N-bis(2-hydroxybenzyl)ethylenediamine-N,N-diacetic acid (HBED) for the chronic treatment of transfusional iron overload, we compared the iron excretion induced by subcutaneous (SC) injection of HBED and deferoxamine (DFO), the reference chelator, in rodents and primates. In the non–iron-overloaded, bile-duct–cannulated rat, a single SC injection of HBED, 150 μmol/kg, resulted in a net iron excretion that was more than threefold greater than that after the same dose of DFO. In the i

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18

Hershko, C., G. Link, A. Pinson, HH Peter, P. Dobbin, and RC Hider. "Iron mobilization from myocardial cells by 3-hydroxypyridin-4-one chelators: studies in rat heart cells in culture." Blood 77, no. 9 (1991): 2049–53. http://dx.doi.org/10.1182/blood.v77.9.2049.2049.

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Abstract The ability of 3-hydroxypyridin-4-ones (CP), a family of bidentate orally effective iron chelators, to remove iron and to prevent iron- induced lipid peroxidation was studied in beating rat myocardial cells in culture. The iron (III) binding constant (log beta 3) of all CP compounds is 36, but their lipophilicity may be modified by altering the length of the R2 substituent on the ring nitrogen. There was a direct relation between lipid solubility and chelating efficiency. Although at high concentrations all CP compounds were more effective in iron mobilization than deferoxamine, the o

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19

Hershko, C., G. Link, A. Pinson, HH Peter, P. Dobbin, and RC Hider. "Iron mobilization from myocardial cells by 3-hydroxypyridin-4-one chelators: studies in rat heart cells in culture." Blood 77, no. 9 (1991): 2049–53. http://dx.doi.org/10.1182/blood.v77.9.2049.bloodjournal7792049.

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The ability of 3-hydroxypyridin-4-ones (CP), a family of bidentate orally effective iron chelators, to remove iron and to prevent iron- induced lipid peroxidation was studied in beating rat myocardial cells in culture. The iron (III) binding constant (log beta 3) of all CP compounds is 36, but their lipophilicity may be modified by altering the length of the R2 substituent on the ring nitrogen. There was a direct relation between lipid solubility and chelating efficiency. Although at high concentrations all CP compounds were more effective in iron mobilization than deferoxamine, the opposite w

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20

Singh, S., Hh Khodr, M. I. Taylor, and R. C. Hider. "Therapeutic iron chelators and their potential side-effects." Biochemical Society Symposia 61 (November 1, 1995): 127–37. http://dx.doi.org/10.1042/bss0610127.

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A number of iron-chelating agents are currently being considered as orally active alternatives to desferrioxamine (DFO), the therapeutic agent for the treatment of body iron overload that is available at present. These include bidentate hydroxypyridinones (HPO), tridentate desferrithiocin (DFT) analogues and hexadentate aminocarboxylate (HBED) chelators. All chelating agents have the potential to induce toxic effects when iron homoeostasis is affected within the body. This can arise when the absorption, distribution and utilization of iron is affected. Alternatively, chelating agents can induc

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21

Shrader, William D., Joseph Celebuski, Steven J. Kline, and David Johnson. "Synthesis of a novel hexadentate chelating agent based on8-hydroxyquinoline." Tetrahedron Letters 29, no. 12 (1988): 1351–54. http://dx.doi.org/10.1016/s0040-4039(00)80294-4.

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22

Gladstone, Igor, N. J. Rose, and E. C. Lingafelter. "Interligand repulsion energy and the twisting of hexadentate chelating ligands." Inorganic Chemistry 25, no. 10 (1986): 1516–18. http://dx.doi.org/10.1021/ic00230a003.

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23

Kane, Charles T., Sudhakar Rao Vadapalli, and Md Tafazzal Hossain. "Rapid One-Pot Microwave-Assisted Synthesis of a Hexadentate Chelating Agent." Synlett, no. 2 (2005): 283–84. http://dx.doi.org/10.1055/s-2004-837207.

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Li, Ruo-Yan, Xiao-Xin An, Ji-Fa Wang, et al. "A Self-Assembled Hetero-Bimetallic [Ni(II)-Sm(III)] Coordination Polymer Constructed from a Salamo-Like Ligand and 4,4′-Bipyridine: Synthesis, Structural Characterization, and Properties." Crystals 10, no. 7 (2020): 579. http://dx.doi.org/10.3390/cryst10070579.

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An unusual self-assembled hetero-bimetallic [Ni(II)-Sm(III)] coordination polymer, [Ni(L)Sm(NO3)3(4,4′-bipy)]n, is prepared through a hexadentate chelating ligand 2,2′-[1,2-ethylenedioxybis(nitrilomethylidyne)]diphenol (H2L). The Ni(II)-Sm(III) coordination polymer is validated through elemental analyses, Fourier-transform infrared and UV-Visible spectroscopies, and X-ray single-crystal diffraction. The Ni(II) atom forms a twisted six-coordinated octahedron, and the Sm(III) atom is ten-coordinated, adopting a twisted bicapped square antiprism. An infinite three-dimensional-layer supramolecular

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Wang, Gui-Xia, Li-Li Shang, Zhao-Hao Li, and Bang-Tun Zhao. "A new two-dimensional manganese(II) coordination polymer based on thiophene-3,4-dicarboxylic acid." Acta Crystallographica Section C Structural Chemistry 70, no. 7 (2014): 715–17. http://dx.doi.org/10.1107/s205322961401417x.

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A novel manganese coordination polymer, poly[(μ5-thiophene-3,4-dicarboxylato)manganese(II)], [Mn(C6H2O4S)]n, was synthesized hydrothermally using 3,4-thiophenedicarboxylate (3,4-tdc2−) as the organic linker. The asymmetric unit of the complex contains an Mn2+cation and one half of a deprotonated 3,4-tdc2−anion, both residing on a twofold axis. Each Mn2+centre is six-coordinated by O atoms of bridging/chelating carboxylate groups from five 3,4-tdc2−anions, forming a slightly distorted octahedron. The Mn2+centres are bridged by 3,4-tdc2−anions to give an infinite two-dimensional layer which inco

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Hodges, Yvonne K., Howard D. Weinberger, Janet Stephens, Marcus A. Horwitz, and Lawrence D. Horwitz. "Desferri-Exochelin, a lipid-soluble, hexadentate iron chelator, effectively removes tissue iron." Translational Research 148, no. 2 (2006): 63–71. http://dx.doi.org/10.1016/j.trsl.2006.03.003.

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Floresta, Giuseppe, George P. Keeling, Siham Memdouh, Levente K. Meszaros, Rafael T. M. de Rosales, and Vincenzo Abbate. "NHS-Functionalized THP Derivative for Efficient Synthesis of Kit-Based Precursors for 68Ga Labeled PET Probes." Biomedicines 9, no. 4 (2021): 367. http://dx.doi.org/10.3390/biomedicines9040367.

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Hexadentate tris(3,4-hydroxypyridinone) ligands (THP) complex Fe3+ at very low iron concentrations and their high affinities for oxophilic trivalent metal ions have led to their development for new applications as bifunctional chelators for the radiometal gallium-68 (68Ga). THP-peptide bioconjugates rapidly and quantitatively complex 68Ga at room temperature, neutral pH, and micromolar ligand concentrations, making them amenable to kit-based radiosynthesis of 68Ga PET radiopharmaceuticals. With the aim to produce an N-hydroxysuccinimide-(NHS)-THP reagent for kit-based 68Ga-labeling and PET ima

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Bergeron, Raymond J., Jan Wiegand, and Gary M. Brittenham. "HBED ligand: preclinical studies of a potential alternative to deferoxamine for treatment of chronic iron overload and acute iron poisoning." Blood 99, no. 8 (2002): 3019–26. http://dx.doi.org/10.1182/blood.v99.8.3019.

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Abstract We have continued the preclinical evaluation of the efficacy and safety of the hexadentate phenolic aminocarboxylate iron chelatorN, N′-bis(2-hydroxybenzyl) ethylenediamine-N, N′-diacetic acid monosodium salt (NaHBED) for the treatment of both chronic transfusional iron overload and acute iron poisoning. We examined the effect of route of administration by giving equimolar amounts of NaHBED and deferoxamine (DFO) to Cebus apella monkeys as either a subcutaneous (SC) bolus or a 20-minute intravenous (IV) infusion. By both routes, NaHBED was consistently about twice as efficient as DFO

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Aazam, Elham, and Martyn Coles. "Simple generation of neutral bimetallic aluminium and zinc alkyls Schiff bases bridged by a central resorcinol moiety." Open Chemistry 8, no. 6 (2010): 1305–10. http://dx.doi.org/10.2478/s11532-010-0107-y.

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AbstractAluminium and zinc complexes bearing the N,O-chelating Schiff base ligand 4,6-bis-1-(2-(dimethylamino)ethylimino)ethyl)benzene-1,3-diol, (C6H2(OH)2(NCH2CH2NMe2)2) (1a), have been synthesized. Bimetallic aluminium and zinc alkyl complexes (2a–4a) were prepared by treatment of the hexadentate 1a with the appropriate amount of AlMe3, ZnMe2 and ZnEt2, respectively. 2a has been characterized crystallographically, it lies on a crystallographic two-fold rotation axis and each aluminium centre adopts a five coordinate geometry. Complex 2a was tested as a catalyst in the ring-opening polymerisa

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Makarem, Ata, Mohammadreza Kamali Sarvestani, Karel D. Klika, and Klaus Kopka. "A Multifunctional HBED-Type Chelator with Dual Conjugation Capabilities for Radiopharmaceutical Development." Synlett 30, no. 15 (2019): 1795–98. http://dx.doi.org/10.1055/s-0039-1690194.

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Bifunctional HBED chelators are hexadentate complexing ligands (chelators) that tightly coordinate to trivalent gallium and, additionally, are able to bind to bioactive molecules. In nuclear medicine, HBED-based radiopharmaceuticals are used as powerful radiotracers for tumor imaging. Among variants of bifunctional HBED chelators, HBED-CC is the most well-known; it possesses two terminal carboxylic acid groups that are able to undergo bioconjugation by amide-bond formation. However, to permit bioconjugation through click coupling, we previously modified the structure of HBED-CC and introduced

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Parihar, Sanjay, R. N. Jadeja, and Vivek K. Gupta. "C3 symmetric vanadium(iii) complexes with O,N-chelating hexadentate tripodal ligands of pyrazolone." RSC Adv. 4, no. 83 (2014): 43994–97. http://dx.doi.org/10.1039/c4ra04021j.

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Novel C<sub>3</sub> symmetric vanadium(iii) complexes of tripodal ligands of pyrazolones were synthesized and characterized by various spectroscopic and analytical techniques including single crystal XRD.

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Queirós, Carla, Andreia Leite, Ana M. G. Silva, Paula Gameiro, Baltazar de Castro, and Maria Rangel. "Synthesis and spectroscopic characterization of a new tripodal hexadentate iron chelator incorporating catechol units." Polyhedron 87 (February 2015): 1–7. http://dx.doi.org/10.1016/j.poly.2014.10.003.

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Lucarini, Fiorella, David Bongni, Philippe Schiel, et al. "Rationalizing Photo‐Triggered Hydrogen Evolution Using Polypyridine Cobalt Complexes: Substituent Effects on Hexadentate Chelating Ligands." ChemSusChem 14, no. 8 (2021): 1874–85. http://dx.doi.org/10.1002/cssc.202100161.

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Feiner, Irene V. J., Marie Brandt, Joseph Cowell, et al. "The Race for Hydroxamate-Based Zirconium-89 Chelators." Cancers 13, no. 17 (2021): 4466. http://dx.doi.org/10.3390/cancers13174466.

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Metallic radionuclides conjugated to biological vectors via an appropriate chelator are employed in nuclear medicine for the diagnosis (imaging) and radiotherapy of diseases. For the application of radiolabeled antibodies using positron emission tomography (immunoPET), zirconium-89 has gained increasing interest over the last decades as its physical properties (t1/2 = 78.4 h, 22.6% β+ decay) match well with the slow pharmacokinetics of antibodies (tbiol. = days to weeks) allowing for late time point imaging. The most commonly used chelator for 89Zr in this context is desferrioxamine (DFO). How

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Sundaresan, Sriram, Irina Kühne, Conor Kelly, et al. "Anion Influence on Spin State in Two Novel Fe(III) Compounds: [Fe(5F-sal2333)]X." Crystals 9, no. 1 (2018): 19. http://dx.doi.org/10.3390/cryst9010019.

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Structural and magnetic data on two iron (III) complexes with a hexadentate Schiff base chelating ligand and Cl− or BPh4− counterions are reported. In the solid state, the Cl− complex [Fe(5F-sal2333)]Cl, 1, is high spin between 5–300 K while the BPh4− analogue [Fe(5F-sal2333)]BPh4, 2, is low spin between 5–250 K, with onset of a gradual and incomplete spin crossover on warming to room temperature. Structural investigation reveals different orientations of the hydrogen atoms on the secondary amine donors in the two salts of the [Fe(5F-sal2333)]+ cation: high spin complex [Fe(5F-sal2333)]Cl, 1,

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Russelli, Lisa, Francesco De Rose, Loredana Leone, et al. "A Semi Rigid Novel Hydroxamate AMPED-Based Ligand for 89Zr PET Imaging." Molecules 26, no. 19 (2021): 5819. http://dx.doi.org/10.3390/molecules26195819.

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In this work, we designed, developed, characterized, and investigated a new chelator and its bifunctional derivative for 89Zr labeling and PET-imaging. In a preliminary study, we synthesized two hexadentate chelators named AAZTHAS and AAZTHAG, based on the seven-membered heterocycle AMPED (6-amino-6-methylperhydro-1,4-diazepine) with the aim to increase the rigidity of the 89Zr complex by using N-methyl-N-(hydroxy)succinamide or N-methyl-N-(hydroxy)glutaramide pendant arms attached to the cyclic structure. N-methylhydroxamate groups are the donor groups chosen to efficiently coordinate 89Zr. A

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Kherfi, Hamza, Malika Hamadène, Achoura Guehria-Laidoudi, Slimane Dahaoui, and Claude Lecomte. "Comparative study of two oxalate isomers with different dimensionalities." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C656. http://dx.doi.org/10.1107/s2053273314093437.

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We report here two bimetallic oxalate isomers with the same chemical formula [RbCr(C2O4)2(H2O)2], which have been synthesized respectively by a slow evaporation method at room temperature (compound I) [1], and under hydrothermal conditions (compound II) [2] with the same starting salts. Their structures show a several discrepancies, due probably to the synthetic conditions. Indeed, the compound I crystallizes in space group C2/m with the Cr, Rb atoms and one oxygen from water molecule lying on special positions. Moreover, the unique oxalate ligand forms a bridge between metal centers. The Cr a

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Zhou, Tao, Xiao Le Kong, Zu Dong Liu, Ding Yong Liu, and Robert C. Hider. "Synthesis and Iron(III)-Chelating Properties of Novel 3-Hydroxypyridin-4-one Hexadentate Ligand-Containing Copolymers." Biomacromolecules 9, no. 5 (2008): 1372–80. http://dx.doi.org/10.1021/bm701122u.

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Zhang, Qingchun, Bo Jin, Shufan Feng, et al. "New hexadentate tris(dopamine) as iron chelating agent: Synthesis, solution thermodynamic stability and antioxidant activity studies." Polyhedron 160 (March 2019): 261–67. http://dx.doi.org/10.1016/j.poly.2018.12.053.

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Fernandes, Sofia Sousa, Ana Nunes, Ana Rita Gomes, et al. "Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium." Microbes and Infection 12, no. 4 (2010): 287–94. http://dx.doi.org/10.1016/j.micinf.2010.01.003.

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Rai, Bijaya L., Hicham Khodr, and Robert C. Hider. "Synthesis, physico-chemical and iron(III)-chelating properties of novel hexadentate 3-hydroxy-2(1H)pyridinone ligands." Tetrahedron 55, no. 4 (1999): 1129–42. http://dx.doi.org/10.1016/s0040-4020(98)01091-6.

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Vugts, Danielle J., Chris Klaver, Claudia Sewing, et al. "Comparison of the octadentate bifunctional chelator DFO*-pPhe-NCS and the clinically used hexadentate bifunctional chelator DFO-pPhe-NCS for 89Zr-immuno-PET." European Journal of Nuclear Medicine and Molecular Imaging 44, no. 2 (2016): 286–95. http://dx.doi.org/10.1007/s00259-016-3499-x.

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Das, Priyabrata, Soma Mukhopadhyay, Nirmal Kumar Sarkar, Suvra Mandal, Manoj Kar, and Ashis Mukhopadhyay. "Mugineic acid, active ingredient of wheat grass: an oral novel hexadentate iron chelator in iron overloaded diseases." Journal of Biochemistry 160, no. 3 (2016): 163–76. http://dx.doi.org/10.1093/jb/mvw023.

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Mettrick, Karla, Karl Hassan, Iain Lamont, and David Reid. "The Iron-chelator, N,N’-bis (2-hydroxybenzyl) Ethylenediamine-N,N’-diacetic acid is an Effective Colistin Adjunct against Clinical Strains of Biofilm-Dwelling Pseudomonas aeruginosa." Antibiotics 9, no. 4 (2020): 144. http://dx.doi.org/10.3390/antibiotics9040144.

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Targeting the iron requirement of Pseudomonas aeruginosa may be an effective adjunctive for conventional antibiotic treatment against biofilm-dwelling P. aeruginosa. We, therefore, assessed the anti-biofilm activity of N,N’-bis (2-hydroxybenzyl) ethylenediamine-N,N’-diacetic acid (HBED), which is a synthetic hexadentate iron chelator. The effect of HBED was studied using short-term (microtitre plate) and longer-term (flow-cell) biofilm models, under aerobic, anaerobic, and microaerobic (flow-cell) conditions and in combination with the polymyxin antibiotic colistimethate sodium (colistin). HBE

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Yokel, Robert A., Andrea M. Fredenburg, Patricia W. Durbin, Jide Xu, Mary Kay Rayens, and Kenneth N. Raymond. "The Hexadentate Hydroxypyridinonate TREN‐(Me‐3,2‐HOPO) is a More Orally Active Iron Chelator Than Its Bidentate Analogue." Journal of Pharmaceutical Sciences 89, no. 4 (2000): 545–55. http://dx.doi.org/10.1002/(sici)1520-6017(200004)89:4<545::aid-jps12>3.0.co;2-j.

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Miroslaw, Barbara, Beata Cristóvão, and Zbigniew Hnatejko. "Structural, Luminescent and Thermal Properties of Heteronuclear PdII–LnIII–PdII Complexes of Hexadentate N2O4 Schiff Base Ligand." Molecules 23, no. 10 (2018): 2423. http://dx.doi.org/10.3390/molecules23102423.

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New PdII–LnIII–PdII complexes of hexadentate N2O4 Schiff base ligand (H4L: N,N′-bis(2,3-dihydroxybenzylidene)-1,3-diamino-2,2-dimethylpropane) with Eu (1), Tb (2), Er (3) and Yb (4) ([Pd2Eu(H2L)2NO3](NO3)2∙2H2O∙2CH3OH 1, [Pd2Ln(H2L)2H2O](NO3)3∙3H2O, where Ln = Tb 2, Er 3, [Pd2Yb(H2L)2H2O](NO3)3∙5.5H2O 4) were synthesized and characterized structurally and physicochemically by thermogravimetry (TG), differential thermogravimetry (DTG), differential scanning calorimetry (DSC) and luminescence measurements. The compounds 1–4 are built of cationic heterometallic PdII–LnIII–PdII trinuclear units. T

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Wang, Ruihu, Maochun Hong, Weiping Su, Rong Cao, Yingjun Zhao, and Jiabao Weng. "Syntheses and Crystal Structures of Silver(I) Organosulfur Polymers as One-Dimensional Chains." Australian Journal of Chemistry 56, no. 11 (2003): 1167. http://dx.doi.org/10.1071/ch01130.

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Two silver(I) organosulfur coordination polymers, {[Ag2(mbpsq).dmf](NO3)2}n (1) and {[Ag3(bpsp)2(CH3CN)]-(BF4)3.2 H2O}n (2), were prepared by self-assembly of silver(I) with the chelating heterocyclic ligands mbpsq and bpsp (mbpsq = 2,3-bis[2-(4-methylpyrimidinyl)methylsulfanyl]-quinoxaline; bpsp = 2,6-bis[(2-pyrimidinyl)-methylsulfanyl]-pyridine). Single-crystal X-ray diffraction analysis reveals that (1) crystallizes in the triclinic space group P1– with a 10.1937(8), b 11.2160(9), c 13.8445(11) Å, α 103.0620(10), β 106.4850(10), γ; 96.2720(10)°, V 1452.8(2) Å3, Z 2. Each mbpsq molecule acts

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Rivkin, Gurion, Gabriela Link, Elliot Simhon, Rosa L. Cyjon, Joseph Y. Klein, and Chaim Hershko. "IRC011, a New Synthetic Chelator With Selective Interaction With Catabolic Red Blood Cell Iron: Evaluation in Hypertransfused Rats With Hepatocellular and Reticuloendothelial Radioiron Probes and in Iron-Loaded Rat Heart Cells in Culture." Blood 90, no. 10 (1997): 4180–87. http://dx.doi.org/10.1182/blood.v90.10.4180.

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Abstract A major consideration in the selection of new and improved iron chelators for clinical use is preferential interaction with the most toxic iron compartment. We describe the biologic properties of a new synthetic hexadentate iron chelator (IRC011) that is a substituted polyaza compound. Unlike deferoxamine (DF ), the polyaza structure of IRC011 does not contain any readily hydrolyzable covalent bonds and is anticipated to resist in vivo biotransformation. In the present studies, the ability of IRC011 to remove radioiron from iron-loaded heart cells in vitro was similar to DF, with a de

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Rai, Bijaya L., Hicham Khodr, and Robert C. Hider. "ChemInform Abstract: Synthesis, Physico-Chemical and Iron(III)-Chelating Properties of Novel Hexadentate 3-Hydroxy-2(1H)pyridinone Ligands." ChemInform 30, no. 22 (2010): no. http://dx.doi.org/10.1002/chin.199922141.

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Łyszczek, Renata, Iwona Rusinek, Agnieszka Ostasz, et al. "New Coordination Polymers of Selected Lanthanides with 1,2-Phenylenediacetate Linker: Structures, Thermal and Luminescence Properties." Materials 14, no. 17 (2021): 4871. http://dx.doi.org/10.3390/ma14174871.

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Solvothermal reactions of lanthanide (III) salts with 1,2-phenylenediacetic acid in N,N′-dimethylformamide (DMF) solvent lead to the formation of the metal complexes of the general formula Ln2(1,2-pda)3(DMF)2, where Ln(III) = Pr(1), Sm(2), Eu(3), Tb(4), Dy(5), and Er(6), 1,2-pda = [C6H4(CH2COO)2]2−. The compounds were characterized by elemental analysis, powder and single-crystal X-ray diffraction methods, thermal analysis methods (TG-DSC and TG-FTIR), infrared and luminescence spectroscopy. They exhibit structural similarity in the two groups (Pr, Sm, and Eu; Tb, Dy, and Er), which was reflec

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