Relevant bibliographies by topics / Hexon Gene

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Hexon Gene'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Hexon Gene"

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Rux, John J., Paula R. Kuser, and Roger M. Burnett. "Structural and Phylogenetic Analysis of Adenovirus Hexons by Use of High-Resolution X-Ray Crystallographic, Molecular Modeling, and Sequence-Based Methods." Journal of Virology 77, no. 17 (2003): 9553–66. http://dx.doi.org/10.1128/jvi.77.17.9553-9566.2003.

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ABSTRACT A major impediment to the use of adenovirus as a gene therapy vector and for vaccine applications is the host immune response to adenovirus hexon—the major protein component of the icosahedral capsid. A solution may lie in novel vectors with modified or chimeric hexons designed to evade the immune response. To facilitate this approach, we have distinguished the portion of hexon that all serotypes have in common from the hypervariable regions that are responsible for capsid diversity and type-specific immunogenicity. The common hexon core—conserved because it forms the viral capsid—set
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Wu, Hongju, Igor Dmitriev, Elena Kashentseva, Toshiro Seki, Minghui Wang, and David T. Curiel. "Construction and Characterization of Adenovirus Serotype 5 Packaged by Serotype 3 Hexon." Journal of Virology 76, no. 24 (2002): 12775–82. http://dx.doi.org/10.1128/jvi.76.24.12775-12782.2002.

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ABSTRACT Adenovirus serotype 5 (Ad5) has great potential for gene therapy applications. A major limitation, however, is the host immune response against Ad5 infection that often prevents the readministration of Ad5 vectors. In this regard, the most abundant capsid protein, hexon, has been implicated as the major target for neutralizing antibodies. In this study, we sought to escape the host neutralization response against Ad5 via hexon replacement. We constructed a chimeric adenovirus vector, Ad5/H3, by replacing the Ad5 hexon gene with the hexon gene of Ad3. The chimeric viruses were successf
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Gall, Jason G. D., Ronald G. Crystal, and Erik Falck-Pedersen. "Construction and Characterization of Hexon-Chimeric Adenoviruses: Specification of Adenovirus Serotype." Journal of Virology 72, no. 12 (1998): 10260–64. http://dx.doi.org/10.1128/jvi.72.12.10260-10264.1998.

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ABSTRACT This study has used the strategy of gene replacement to characterize the contribution of the adenovirus (Ad) capsid protein hexon to serotype definition. By replacing the Ad type 5 (Ad5) hexon gene with sequences from Ad2, we have changed the type specificity of the chimeric virus. The type-determining epitopes are primarily associated with loop 1 of hexon and, to a much lesser degree, with loop 2. In spite of the serotype distinctiveness of the chimeric hexon viruses, epitope similarity between the vectors resulted in a low level of cross-reactive neutralizing antibody, which in comb
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Wu, Hongju, Tie Han, Natalya Belousova, et al. "Identification of Sites in Adenovirus Hexon for Foreign Peptide Incorporation." Journal of Virology 79, no. 6 (2005): 3382–90. http://dx.doi.org/10.1128/jvi.79.6.3382-3390.2005.

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ABSTRACT Adenovirus type 5 (Ad5) is one of the most promising vectors for gene therapy applications. Genetic engineering of Ad5 capsid proteins has been employed to redirect vector tropism, to enhance infectivity, or to circumvent preexisting host immunity. As the most abundant capsid protein, hexon modification is particularly attractive. However, genetic modification of hexon often results in failure of rescuing viable viruses. Since hypervariable regions (HVRs) are nonconserved among hexons of different serotypes, we investigated whether the HVRs could be used for genetic modification of he
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Matsushima, Yuki, Hideaki Shimizu, Tung Gia Phan, and Hiroshi Ushijima. "Genomic characterization of a novel human adenovirus type 31 recombinant in the hexon gene." Journal of General Virology 92, no. 12 (2011): 2770–75. http://dx.doi.org/10.1099/vir.0.034744-0.

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A novel human recombinant adenovirus of species A (HAdV-A31 MZ) was isolated from a patient with acute gastroenteritis in Japan. The complete genome of HAdV-A31 strain MZ contains 33 776 bp. Analysis of the hexon gene of HAdV-A31 MZ indicated that its hexon sequence is the result of a genetic recombination between those of HAdV-A31 and a close relative to HAdV-A12. The recombination sites were found around the border of hypervariable loops 1 and 2 in the hexon gene, which are the most important determinants for virus neutralization. Loops 1 and 2 of this virus were genetically related to HAdV-
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Ostapchuk, Philomena, and Patrick Hearing. "Pseudopackaging of Adenovirus Type 5 Genomes into Capsids Containing the Hexon Proteins of Adenovirus Serotypes B, D, or E." Journal of Virology 75, no. 1 (2001): 45–51. http://dx.doi.org/10.1128/jvi.75.1.45-51.2001.

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ABSTRACT Adenoviruses (Ad) show promise as a vector system for gene delivery in vivo. However, a major challenge in the development of Ad vectors is the circumvention of the host immune responses to Ad infection, including both the host cytotoxic T-cell response and the humoral response resulting in neutralizing antibodies. One method to circumvent the effect of neutralizing antibodies against an Ad vector is to use different Ad serotypes to deliver the transgene of interest. This approach has been demonstrated with Ad genomes of highly related members of subgroup C. However, it is not known w
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Yuming, Fu, Yuan Sheng, Deng Wenyu, et al. "Molecular characterization and phylogenetic analysis of fowl adenovirus serotype-4 from Guangdong Province, China." May-2020 13, no. 5 (2020): 981–86. http://dx.doi.org/10.14202/vetworld.2020.981-986.

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Aim: Our aim in this study was to isolate potentially novel strains of fowl adenovirus serotype-4 (FAdV-4) that is currently circulating in broiler chicken flocks in Guangdong Province, China, and to compare nucleotide and amino acid (AA) sequences of their respective hexon genes. Materials and Methods: The experiment was carried out on poultry farms experiencing outbreaks of FAdV-4-associated hydropericardium syndrome (HPS). Tissue samples from the hearts and livers of deceased chickens were screened for FAdV-4 infection using hexon gene-specific polymerase chain reaction (PCR). Results: New
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Ebner, K., W. Pinsker, and T. Lion. "Comparative Sequence Analysis of the Hexon Gene in the Entire Spectrum of Human Adenovirus Serotypes: Phylogenetic, Taxonomic, and Clinical Implications." Journal of Virology 79, no. 20 (2005): 12635–42. http://dx.doi.org/10.1128/jvi.79.20.12635-12642.2005.

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ABSTRACT The adenovirus (AdV) hexon constitutes the major virus capsid protein. The epitopes located on the hexon protein are targets of neutralizing antibodies in vivo, serve in the recognition by cytotoxic T cells, and provide the basis for the classification of adenoviruses into the 51 serotypes known to date. We have sequenced the entire hexon gene from human serotypes with incomplete or no sequence information available (n = 34) and performed a comparative analysis of all sequences. The overall sequence divergence between the 51 human serotypes ranged from 0.7 to 25.4% at the protein leve
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Onion, David, Laura J. Crompton, Donald W. Milligan, Paul A. H. Moss, Steven P. Lee, and Vivien Mautner. "The CD4+ T-cell response to adenovirus is focused against conserved residues within the hexon protein." Journal of General Virology 88, no. 9 (2007): 2417–25. http://dx.doi.org/10.1099/vir.0.82867-0.

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Adenovirus is a significant pathogen in immunocompromised patients and is widely utilized as a gene delivery vector, so a detailed understanding of the human immune response to adenovirus infection is critical. This study characterized the adenovirus-specific CD4+ T-cell response of healthy donors by incubation with whole virus or with individual hexon and fiber proteins. Adenovirus-specific CD4+ T cells averaged 0.26 % of the CD4+ T-cell pool and were detectable in all donors. T cells recognizing the highly conserved hexon protein accounted for 0.09 %, whereas no response was observed against
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Lei, Yue, Zhichao Zhuang, Yang Liu, et al. "Whole Genomic Sequence Analysis of Human Adenovirus Species C Shows Frequent Recombination in Tianjin, China." Viruses 15, no. 4 (2023): 1004. http://dx.doi.org/10.3390/v15041004.

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Human adenovirus species C (HAdV-C) is frequently detected in China and worldwide. For the first time, 16 HAdV-C strains were isolated from sewage water (14 strains) and hospitalised children with diarrhoea (2 strains,) in Tianjin, China. Nearly complete genome data were successfully obtained for these viruses. Subsequently, genomic and bioinformatics analyses of the 16 HAdV-C strains were performed. A phylogenetic tree of the complete HAdV-C genome divided these strains into three types: HAdV-C1, HAdV-C2, HAdV-C5. Phylogenetic analysis based on the fiber gene showed similar outcomes to analys
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Dissertations / Theses on the topic "Hexon Gene"

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Lana, Marlous Vinicius Gomes. "Utilização de shRNA anti-hexon, anti-IVa2 e anti-pol durante a produção de vírus adeno-associado como estratégia de eliminar Adenovírus helper: prova de princípio." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-13032017-101533/.

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O Adenovírus (Ad) é um agente etiológico que causa infecções em diversas espécies e também pode ser utilizado na forma de vetor como ferramenta tecnológica para terapia gênica. O Controle sobre a replicação de Ad pode trazer beneficio para o combate de infecções e para as tecnologias de transferência genica. Porém, poucas ferramentas existem que podem inibir a replicação de Ad. Uma aplicação importante seria a inibição da replicação de Adenovírus helper utilizado na produção de Vírus Adenoassociado recombinante (rAAV), assim minimizando contaminação da produção de rAAV com o virus helper. Dess
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Lee, Heon-Jin [Verfasser]. "Functional analysis of the murine genes, MOCS1 and Sox15 / vorgelegt von Heon-Jin Lee." 2003. http://d-nb.info/969518897/34.

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Books on the topic "Hexon Gene"

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Mattison, Mike, and Ernest Suarez. Poetic Song Verse. University Press of Mississippi, 2021. http://dx.doi.org/10.14325/mississippi/9781496837271.001.0001.

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This unique and accessibly written study discusses the relationship between the blues, rock, folk, jazz, and poetry in the twentieth and twenty-first centuries, but it is anchored in the 1960s, when a concentration of artists transformed modes of popular music from entertainment to art-that-entertains. The authors (a professional musician and a literary historian) synthesize a wide range of writing about music—biographies, histories, articles in popular magazines, personal reminiscences, and a selective smattering of academic studies—and examine the development of a relatively new literary gen
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Book chapters on the topic "Hexon Gene"

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Bolden, Tony. "Intro." In Groove Theory. University Press of Mississippi, 2020. http://dx.doi.org/10.14325/mississippi/9781496830524.003.0001.

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Groove Theory traces the concept of funk from the beginning of the blues era around 1890 to its manifestation as a full-fledged genre in the 1970s. This chapter provides an introduction. In the chapters, Bolden examines the development of blue funk in a multidimensional discussion that engages songs, fiction, memoirs, interviews, scholarship, and more. The discussion proceeds in two parts. Side A presents a conceptual introduction to funk aesthetics, an historical overview of funk during the blues era, and a chapter on Sly Stone that examines his foundational role as an architect of funk. Side
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Conference papers on the topic "Hexon Gene"

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Berdieva, S. B., D. S. Demina, I. D. Osipov, et al. "OCCURRENCE OF ADENOVIRUS SEROTYPES AMONG PEOPLE WITH ARI IN TASHKENT, REPUBLIC OF UZBEKISTAN." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-176.

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Careful monitoring of acute respiratory infections is carried out only for a limited number of viruses (influenza, parainfluenza, coronaviruses), while other ARVI/ARI pathogens circulate in the population including adenoviruses. In the etiology of acute respiratory viral infections, adenoviruses account for up to 10 % of all cases. Among 686 samples taken from patients hospitalized with acute respiratory infections in Tashkent, 71 were positive for adenoviruses. Of these samples, fragments of the hexon protein gene were sequenced in 10. As a result, three samples of serotype 7 were identified,
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Ali, Mehreen, and Donald Seto. "Phylogenetic analysis of hexon and DNA polymerase genes from selected serotypes of human adenoviruses, using bioinformatics tools." In 2011 IEEE 14th International Multitopic Conference (INMIC). IEEE, 2011. http://dx.doi.org/10.1109/inmic.2011.6151453.

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