Relevant bibliographies by topics / HGPS

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'HGPS'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 April 2022

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Journal articles on the topic "HGPS"

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Udamale, Shilpa K., M. P. Moharil, T. B. Ugale, and J. M. Mankar. "Differential Inhibition of Helicoverpa armigera (Hubner) Gut Proteinases by Proteinase Inhibitors of Okra and It's Wild Relatives." ISRN Biotechnology 2013 (March 17, 2013): 1–10. http://dx.doi.org/10.5402/2013/632173.

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The seeds of ten genotypes and twenty-nine wild relatives of okra were analysed for the presence of trypsin, chymotrypsin, and Helicoverpa gut proteinases (HGPs) inhibitors (HGPIs), with the aim to identify potent inhibitors of H. armigera gut proteinases. Proteinase inhibitors (PIs) obtained from wild relatives of okra exhibited stronger inhibition of HGPs than the genotypes of okra. In in vitro inhibitory assay against HGPs, A. tuberculatus 90396 and 90515 showed high tryptic inhibitory (71.8% and 69.2%), chymotryptic inhibitory (68.5% and 66.2%), and Helicoverpa gut proteinase activity (70.2% and 68.2%). In electrophoretic profile showed the same variation in the number of trypsin inhibitors (TIs), chymotrypsin Inhibitors (CIs), and HGPIs isoforms with different intensities, whereas genotypes of okra mostly showed monomorphic profile. Maximum eight HGPIs isoforms were found in A. tuberculatus (90396 and 90515). In bioassay studies, significant reduction in weight of H. armigera larvae was found, when larvae fed on PIs obtained from A. tuberculatus (90396 and 90515). Thus, the result of the present investigation indicates that further exploration of PIs obtained from A. tuberculatus (90396 and 90515) will be helpful for developing PIs-based insect resistance management strategies.
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Harhouri, Karim, Pierre Cau, Frank Casey, Koffi Mawuse Guedenon, Yassamine Doubaj, Lionel Van Maldergem, Gerardo Mejia-Baltodano, Catherine Bartoli, Annachiara De Sandre-Giovannoli, and Nicolas Lévy. "MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients’ Cells." Cells 11, no. 4 (February 10, 2022): 610. http://dx.doi.org/10.3390/cells11040610.

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Progeroid syndromes (PS), including Hutchinson-Gilford Progeria Syndrome (HGPS), are premature and accelerated aging diseases, characterized by clinical features mimicking physiological aging. Most classical HGPS patients carry a de novo point mutation within exon 11 of the LMNA gene encoding A-type lamins. This mutation activates a cryptic splice site, leading to the production of a truncated prelamin A, called prelamin A ∆50 or progerin, that accumulates in HGPS cell nuclei and is a hallmark of the disease. Some patients with PS carry other LMNA mutations and are named “HGPS-like” patients. They produce progerin and/or other truncated prelamin A isoforms (∆35 and ∆90). We previously found that MG132, a proteasome inhibitor, induced progerin clearance in classical HGPS through autophagy activation and splicing regulation. Here, we show that MG132 induces aberrant prelamin A clearance and improves cellular phenotypes in HGPS-like patients’ cells other than those previously described in classical HGPS. These results provide preclinical proof of principle for the use of a promising class of molecules toward a potential therapy for children with HGPS-like or classical HGPS.
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Röhrl, Jennifer M., Rouven Arnold, and Karima Djabali. "Nuclear Pore Complexes Cluster in Dysmorphic Nuclei of Normal and Progeria Cells during Replicative Senescence." Cells 10, no. 1 (January 14, 2021): 153. http://dx.doi.org/10.3390/cells10010153.

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Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disease caused by a mutation in LMNA. A G608G mutation in exon 11 of LMNA is responsible for most HGPS cases, generating a truncated protein called “progerin”. Progerin is permanently farnesylated and accumulates in HGPS cells, causing multiple cellular defects such as nuclear dysmorphism, a thickened lamina, loss of heterochromatin, premature senescence, and clustering of Nuclear Pore Complexes (NPC). To identify the mechanism of NPC clustering in HGPS cells, we evaluated post-mitotic NPC assembly in control and HGPS cells and found no defects. Next, we examined the occurrence of NPC clustering in control and HGPS cells during replicative senescence. We reported that NPC clustering occurs solely in the dysmorphic nuclei of control and HGPS cells. Hence, NPC clustering occurred at a higher frequency in HGPS cells compared to control cells at early passages; however, in late cultures with similar senescence index, NPCs clustering occurred at a similar rate in both control and HGPS. Our results show that progerin does not disrupt post-mitotic reassembly of NPCs. However, NPCs frequently cluster in dysmorphic nuclei with a high progerin content. Additionally, nuclear envelope defects that arise during replicative senescence cause NPC clustering in senescent cells with dysmorphic nuclei.
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Zhao, Xiao-Ni, Hong-Ping Song, Fan Yang, Dang-Jie Wu, Wen-Qing Gong, Ying Zhang, Xin Sun, and Min-Juan Zheng. "Ultrasonic Characteristics of Cardiovascular Changes in Children with Hutchinson–Gilford Progeria Syndrome: A Comparative Study with Normal Children and Aging People." BioMed Research International 2020 (April 15, 2020): 1–8. http://dx.doi.org/10.1155/2020/9631851.

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Background. The cardiovascular characteristics of children with Hutchinson-Gilford progeria syndrome (HGPS) remain unclear. The present study is aimed at evaluating the cardiovascular changes with ultrasound examination in children with HGPS and compared these with those in normal children and older people. Methods. Seven HGPS children, 21 age-matched healthy children, and 14 older healthy volunteers were evaluated by three-dimensional echocardiography (including strain analysis) and carotid elasticity examination with the echo-tracking technique. Results. Children with HGPS had higher left ventricular ejection fraction (LVEF) and global longitudinal strain, when compared to older healthy volunteers (P<0.05). However, these parameters were not significantly different, when compared to those in healthy children. Furthermore, children with HGPS had lower average peak times in the left ventricle, when compared with the other two groups. For the structure of the carotid artery detected by ultrasound, the abnormality rates were similar between children with HGPS and older healthy volunteers (83.3% vs. 71.4%). The elastic parameters, elastic modulus, stiffness parameter, and pulsed wave transmittal velocity of children with HGPS were lower, when compared to those in older healthy volunteers (P<0.05), while they were higher with arterial compliance (P>0.05). Furthermore, no significant difference existed among the vascular elastic parameters between HGPS and normal children. Conclusion. HGPS children had impaired left ventricular (LV) synchrony, when compared to normal children, although the difference in LVEF was not statistically significant. Furthermore, the structural abnormality of the carotid artery in HGPS children was similar to that in older people, although the index of elasticity appears to be more favorable. These results suggest that the cardiovascular system in HGPS children differs from natural aging.
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von Kleeck, Ryan, Emilia Roberts, Paola Castagnino, Kyle Bruun, Sonja A. Brankovic, Elizabeth A. Hawthorne, Tina Xu, John W. Tobias, and Richard K. Assoian. "Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase." Life Science Alliance 4, no. 5 (March 9, 2021): e202000997. http://dx.doi.org/10.26508/lsa.202000997.

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Arterial stiffening and cardiac dysfunction are hallmarks of premature aging in Hutchinson–Gilford Progeria Syndrome (HGPS), but the molecular regulators remain unknown. Here, we show that the LaminAG609G mouse model of HGPS recapitulates the premature arterial stiffening and early diastolic dysfunction seen in human HGPS. Lysyl oxidase (LOX) is up-regulated in the arteries of these mice, and treatment with the LOX inhibitor, β-aminopropionitrile, improves arterial mechanics and cardiac function. Genome-wide and mechanistic analysis revealed reduced expression of the LOX-regulator, miR-145, in HGPS arteries, and forced expression of miR-145 restores normal LOX gene expression in HGPS smooth muscle cells. LOX abundance is also increased in the carotid arteries of aged wild-type mice, but its spatial expression differs from HGPS and its up-regulation is independent of changes in miR-145 abundance. Our results show that miR-145 is selectively misregulated in HGPS and that the consequent up-regulation of LOX is causal for premature arterial stiffening and cardiac dysfunction.
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von Kleeck, Ryan, Paola Castagnino, and Richard K. Assoian. "Progerin mislocalizes myocardin-related transcription factor in Hutchinson–Guilford Progeria syndrome." Vascular Biology 4, no. 1 (March 1, 2022): 1–10. http://dx.doi.org/10.1530/vb-21-0018.

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Hutchinson–Guilford Progeria syndrome (HGPS) is a rare genetic disease of premature aging and early death due to cardiovascular disease. The arteries of HGPS children and mice are pathologically stiff, and HGPS mice also display reduced arterial contractility. We recently showed that reduced contractility is an early event in HGPS and linked to an aberrantly low expression of smooth muscle myosin heavy chain (smMHC). Here, we have explored the basis for reduced smMHC abundance and asked whether it is a direct effect of progerin expression or a longer-term adaptive response. Myh11, the gene encoding for smMHC, is regulated by myocardin-related transcription factors (MRTFs), and we show that HGPS aortas have a reduced MRTF signature. Additionally, smooth muscle cells (SMCs) isolated from HGPS mice display reduced MRTF nuclear localization. Acute progerin expression in WT SMCs phenocopied both the decrease in MRTF nuclear localization and expression of Myh11 seen in HGPS. Interestingly, RNA-mediated depletion of MRTF-A in WT SMCs reproduced the preferential inhibitory effect of progerin on Myh11 mRNA relative to Acta2 mRNA. Our results show that progerin expression acutely disrupts MRTF localization to the nucleus and suggest that the consequent decrease in nuclear coactivator activity can help to explain the reduction in smMHC abundance and SMC contractility seen in HGPS.
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Kreienkamp, Ray, and Susana Gonzalo. "Metabolic Dysfunction in Hutchinson–Gilford Progeria Syndrome." Cells 9, no. 2 (February 8, 2020): 395. http://dx.doi.org/10.3390/cells9020395.

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Hutchinson–Gilford Progeria Syndrome (HGPS) is a segmental premature aging disease causing patient death by early teenage years from cardiovascular dysfunction. Although HGPS does not totally recapitulate normal aging, it does harbor many similarities to the normal aging process, with patients also developing cardiovascular disease, alopecia, bone and joint abnormalities, and adipose changes. It is unsurprising, then, that as physicians and scientists have searched for treatments for HGPS, they have targeted many pathways known to be involved in normal aging, including inflammation, DNA damage, epigenetic changes, and stem cell exhaustion. Although less studied at a mechanistic level, severe metabolic problems are observed in HGPS patients. Interestingly, new research in animal models of HGPS has demonstrated impressive lifespan improvements secondary to metabolic interventions. As such, further understanding metabolism, its contribution to HGPS, and its therapeutic potential has far-reaching ramifications for this disease still lacking a robust treatment strategy.
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Najdi, Farah, Peter Krüger, and Karima Djabali. "Impact of Progerin Expression on Adipogenesis in Hutchinson—Gilford Progeria Skin-Derived Precursor Cells." Cells 10, no. 7 (June 25, 2021): 1598. http://dx.doi.org/10.3390/cells10071598.

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Hutchinson–Gilford progeria syndrome (HGPS) is a segmental premature aging disease caused by a mutation in LMNA. The mutation generates a truncated and farnesylated form of prelamin A, called progerin. Affected individuals develop several features of normal aging, including lipodystrophy caused by the loss of general subcutaneous fat. To determine whether premature cellular senescence is responsible for the altered adipogenesis in patients with HGPS, we evaluated the differentiation of HGPS skin-derived precursor stem cells (SKPs) into adipocytes. The SKPs were isolated from primary human HGPS and normal fibroblast cultures, with senescence of 5 and 30%. We observed that the presence of high numbers of senescent cells reduced SKPs’ adipogenic differentiation potential. Treatment with baricitinib, a JAK–STAT inhibitor, ameliorated the ability of HGPS SKPs to differentiate into adipocytes. Our findings suggest that the development of lipodystrophy in patients with HGPS may be associated with an increased rate of cellular senescence and chronic inflammation.
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Maloney, W. J. "Hutchinson-Gilford Progeria Syndrome: Its Presentation in F. Scott Fitzgerald’s Short Story ‘The Curious Case of Benjamin Button’ and Its Oral Manifestations." Journal of Dental Research 88, no. 10 (September 25, 2009): 873–76. http://dx.doi.org/10.1177/0022034509348765.

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Hutchinson-Gilford Progeria Syndrome (HGPS) was first documented in the medical literature in 1886. A HGPS patient has the physical characteristics and appearances of an elderly individual. In 1921, F. Scott Fitzgerald published a short story entitled ‘The Curious Case of Benjamin Button’. The main character of Fitzgerald’s fictional work is born with a very rare condition in which he looks like an elderly person. The main difference between the fictional individual and individuals with HGPS is that Fitzgerald’s character becomes younger as the years go by. This paper serves three purposes. The first purpose is to scientifically present the possibility that Fitzgerald consciously based his character, Benjamin Button, upon individuals with HGPS. The second purpose is to describe the rare condition of HGPS, along with its many manifestations in the head and neck region. The third purpose is to postulate that HGPS individuals might not only have the appearance of an aged person, but also might actually undergo true physical aging, which would enable researchers to gain valuable information into the treatment of ailments commonly associated with the natural process of aging.
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Strandgren, Charlotte, Gwladys Revêchon, Agustín Sola Carvajal, and Maria Eriksson. "Emerging candidate treatment strategies for Hutchinson-Gilford progeria syndrome." Biochemical Society Transactions 45, no. 6 (November 10, 2017): 1279–93. http://dx.doi.org/10.1042/bst20170141.

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Hutchinson-Gilford progeria syndrome (HGPS, progeria) is an extremely rare premature aging disorder affecting children, with a disease incidence of ∼1 in 18 million individuals. HGPS is usually caused by a de novo point mutation in exon 11 of the LMNA gene (c.1824C>T, p.G608G), resulting in the increased usage of a cryptic splice site and production of a truncated unprocessed lamin A protein named progerin. Since the genetic cause for HGPS was published in 2003, numerous potential treatment options have rapidly emerged. Strategies to interfere with the post-translational processing of lamin A, to enhance progerin clearance, or directly target the HGPS mutation to reduce the progerin-producing alternative splicing of the LMNA gene have been developed. Here, we give an up-to-date resume of the contributions made by our and other research groups to the growing list of different candidate treatment strategies that have been tested, both in vitro, in vivo in mouse models for HGPS and in clinical trials in HGPS patients.
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Dissertations / Theses on the topic "HGPS"

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Kocharyan, Avetik. "Derivation and Characterization of Pax7 Positive Skeletal Muscle Precursor Cells from Control and HGPS-derived induced Pluripotent Stem Cells." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37517.

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Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder associated with premature aging in various tissues and organs of the afflicted individuals, including accelerated skeletal muscle atrophy. Classical HGPS manifests due to single-base substitution in the LAMNA gene which encodes Lamin A/C proteins. As a result of the mutation, a truncated form of Lamin (known as Progerin) is produced which undergoes persistent farnesylation during post-translational modification. Accumulation of Progerin in the nucleus has been linked to various cellular abnormalities including abnormal nuclear morphologies and altered chromatin organization, among others. However, the exact molecular mechanisms leading to skeletal muscle atrophy have not yet been elucidated. In this study, the iPSC approach was implemented in order to study the skeletal muscle phenotype of HGPS by generating and characterizing a population of Pax7 positive skeletal muscle precursor cells (SMPs). During the course of this project, we have demonstrated the need for excessive optimization of the previously developed directed differentiation protocol for successful application on induced Pluripotent Stem Cells. Furthermore, we have successfully modified the protocol to allow for a more rapid expansion of the SMPs through regular passaging of the myogenic cells starting on day 20 of differentiation. Additionally, this new method produced more uniform distribution of the myogenic cells and allowed for successful freezing/thawing of the myogenic cells. When compared to the controls, the HGPS-derived SMPs did not appear to be defective in formation, proliferation or differentiation. Abnormal nuclear morphology and DNA damage, documented in HGPS fibroblasts and vascular smooth muscle cells, were not detected the in myogenic cells. Furthermore, we were not able to detect Progerin protein accumulation in the generated myogenic cultures, offering an explanation for the absence of these phenotypes in the skeletal muscle system.
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Gabriel, Diana [Verfasser], Karima [Akademischer Betreuer] Djabali, Bernhard [Gutachter] Küster, Karima [Gutachter] Djabali, and Angelika [Gutachter] Noegel. "Towards restoring the protein degradation pathway(s) in Hutchinson-Gilford progeria syndrome (HGPS) / Diana Gabriel ; Gutachter: Bernhard Küster, Karima Djabali, Angelika Noegel ; Betreuer: Karima Djabali." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/118506947X/34.

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Liu, Chang [Verfasser], Karima [Akademischer Betreuer] Djabali, Thomas [Gutachter] Brück, and Karima [Gutachter] Djabali. "Baricitinib reduces inflammation and improves cell homeostasis of HGPS fibroblasts by inhibiting JAK-STAT signaling / Chang Liu ; Gutachter: Thomas Brück, Karima Djabali ; Betreuer: Karima Djabali." München : Universitätsbibliothek der TU München, 2021. http://d-nb.info/123513959X/34.

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Johnson, McKayla. "The Effect of Ultraviolet Light on Cell Viability, DNA Damage and Repair in Hutchinson-Gilford Progeria Syndrome and BJ Fibroblasts." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/honors/90.

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Patients of Hutchinson-Gilford Progeria Syndrome (HGPS) display a rate of aging up to ten times that of normal human populations. It might be expected that HGPS cells would have a decreased ability to repair DNA damage through the cell cycle as compared to normal cells such as those of the BJ cell line since DNA damage accumulation is a hallmark phenotype of aging. On earth, we are exposed to far more ultraviolet-B (UV-B, 280-315 nm) and UV-A (315-400 nm) than UV-C (100-280 nm) radiation, since the latter is filtered-out by the atmospheric ozone layer. The relative sensitivity of prematurely aging HGPS cells to UV-B irradiation is unknown. It was hypothesized that the normal fibroblast cell line (BJ) would exhibit a higher rate of DNA repair and a higher level of cell viability after exposure to ultraviolet radiation than would be observed with the HGPS cells, and that these differences would be greater as the HGPS cells age in culture. A Cell-Titer Blue Viability Assay (Promega) was used to determine the effect of UV-B and UV-C on metabolic activity, an indicator for cell viability, in HGPS, BJ, and A549 (a human lung carcinoma) cells. A translesion DNA synthesis protein, pol-η, and several other DNA transcription and repair-related proteins also were hypothesized to be altered in the HGPS cell line, both before and after UV-induced DNA damage, as compared to the BJ cell line. Western blotting was used to monitor these proteins in BJ and HGPS cells following UV-C exposure. No differences in short-term viability were observed between BJ and HGPS cells, reflecting similarities in their repair abilities on the cellular level; however, there were significant differences in long-term viability. Enzyme Linked Immunosorbant Assays (ELISA) revealed a significant difference in DNA repair at the molecular level. Moreover, Western blotting revealed differences in the amounts of several repair-related proteins following UV exposure, including pol-η, an important trans-lesion synthesis protein. Although the difference in DNA repair did not appear at the cellular level, it is apparent that HGPS cells show a greater sensitivity to both UV-B and UV-C irradiation as compared to normal BJ fibroblasts and A549 carcinoma cells.
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Levesque, Steve. "DNA Methylation, Cellular Stress Response and Expression of Inner Nuclear Membrane Proteins." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19949.

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Hutchinson-Gilford Progeria Syndrome is described as a series of mutations within the lamin A gene leading to the accumulation of progerin in the nucleus, contributing to premature aging and affecting the epigenetic control. Epigenetic control, such as DNA methylation, relies on DNA methyltransferase enzymes. In human cells, heat shock (HS) leads to the formation of nuclear stress bodies (nSBs); ribonucleoprotein aggregates of Sat III RNA and RNA-binding proteins. The objectives of this study were to determine if epigenetic status induces varying responses to HS and assess the variability of nuclear proteins in similar conditions. Results show epigenetic modifications do not prevent a stress response; however the extent may be affected. In addition the functions of most nuclear antigens were not affected. It is most likely the sum of interactions at the inner nuclear membrane and nuclear lamina interface that result in nuclear strength pertaining to lamin A.
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Fernandes, Luiz Carlos do Carmo. "Possibilidades contra-hegemônicas da cidadania na construção do HGPE." Universidade Federal de Goiás, 2009. http://repositorio.bc.ufg.br/tede/handle/tde/1412.

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Made available in DSpace on 2014-07-29T15:22:33Z (GMT). No. of bitstreams: 1 dissertacao luiz fernandes.pdf: 553158 bytes, checksum: 8471ccb04c568beedb227fa26fa836f9 (MD5) Previous issue date: 2009-04-03
Based on qualitative researches done by political marketing group during the elective period aimed the legitimacy of political discourse on the free tv elective program, this work verifies the not hegemonic possibilities of civil society in building the agenda of that discourse and, as a result, empowering the democracy and the citizenship. The political rationality of the poor citizens was investigated by comparing it to the dominant classes. this study also investigated the subjects and perceptions raised in the qualitative researches and its match to the public interest to the political citizenship, besides its reflection in the tv program. The methodology was the same suggested by palacios (2007) in digital journalism. first, a literature review was done considering democracy and citizenship concepts. after that, the research object was delimited- the elective discourse on free tv elective program, followed by the citizen agenda hypothesis. then, analysis categories to do the empirical study seen in here as a case study was created by using qualitative researches done during municipal election in 2008 in Goiânia. It was done in two moments. in the first (pre-elective, 45 days before the propaganda ruled by elective justice court) the collected material was analyzed according to oliveira´s interactive methodology (2007). in the second moment, the results were compared to the free tv elective program conducted by the winner candidate.The conclusion is that citizenship is not a factor of influence in the political discourse agenda. it is not due to other discourses such as the media , negative propaganda or interferences in political field, but because there is a consolidate idea among poor citizens against political discussions in primary communicative spaces, where micro or alternative public spheres could exist. there were not agreements or understandings among those citizens which could convince the politicians to include them in their discourses
Tomando como base as pesquisas qualitativas, realizadas pelo marketing político no período eleitoral, com o objetivo estratégico de legitimar o discurso político no Horário Gratuito de Propaganda Eleitoral, esse trabalho verifica as possibilidades contra-hegemônicas da sociedade civil de fazer o agendamento desse mesmo discurso, fortalecendo a democracia e a cidadania. Procurou-se investigar a racionalidade política nos subcidadãos das classes subalternas, em comparação com as classes privilegiadas ou classes dominantes; verificar os temas e percepções levantadas nas pesquisas qualitativas e sua aproximação do interesse público e da cidadania política, bem como seus reflexos no discurso político eleitoral transmitido através do HGPE. A metodologia utilizada nesta dissertação foi a de Palácios (2007) para estudar o jornalismo digital. Inicialmente foi realizada uma revisão bibliográfica sobre os conceitos de democracia e cidadania para, em seguida, delimitar o objeto dessa dissertação que é o discurso eleitoral veiculado através do Horário Gratuito de Propaganda Eleitoral e formular hipótese de agendamento cidadão. Num terceiro momento, foram elaboradas as categorias de análise para a realização do estudo empírico por meio de um estudo de caso utilizando as pesquisas qualitativas nas eleições municipais de 2008 em Goiânia, em dois momentos: o primeiro, pré-eleitoral, iniciado um mês antes da eleição, e outro, eleitoral, durante os 45 dias de propaganda estabelecida pela Justiça Eleitoral. O material coletado foi processado e analisado com base na Metodologia Interativa de Oliveira (2007) e, ao final, comparado com o HGPE do candidato vencedor do pleito.A conclusão a que se chegou é que a cidadania não tem grande influência como fator de agendamento do discurso político eleitoral. Não porque divide com outros fatores a possibilidade de agendamento do discurso político no caso: a mídia, a propaganda negativa e as interferências do campo político , mas sim porque há uma consolidada aversão dos eleitores das classes subalternas em levar para os espaços comunicativos primários a discussão política que transformaria esses espaços em micro esferas públicas ou esferas públicas alternativas e, conseqüentemente, permitisse a realização de um consenso que chegue a um lugar de entendimento que contemple a todos e possa ser apresentado como argumento de convencimento dos atores políticos para se fazer o agendamento cidadão
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Zulqarnain, Kamran. "Scale-up of affinity separation based on magnetic support particles." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313426.

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Oliveira, Christine Bahia de. "Horário gratuito político eleitoral - HGPE: o leitor e a cidadania política." Pontifícia Universidade Católica do Rio Grande do Sul, 2008. http://hdl.handle.net/10923/2058.

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The modern world differs fundamentally from former epochs by virtue of the comprehensive, transforming phenomenon of communication. Fastened on this phenomenon, political speeches, particularly when delivered over nationwide television, get across to everyone in a democratic manner by enticing and inducing voters into casting their ballots for a certain candidate or party. Nonetheless, amongst so many appeals, which one will strengthen me as a citizen? To which am I to surrender myself; with which should I comply? The present study has the purpose of providing the reader with a deeper and more perceptive view to the material presented on the free political electoral time, HGPE. The approach takes place with qualitative and quantitative insight, comprising a contemplative and critical movement toward the meaning of Political Marketing versus Electoral Marketing, and the understanding of how these concepts, applied to HGPE, would heighten or lessen the elements that build up voters into politicized citizens.
O mundo moderno se diferencia das épocas anteriores, fundamentalmente, pelo fenômeno abrangente e transformador da comunicação. Ancorado a este fenômeno o discurso político pronunciado, principalmente, na televisão chega democraticamente a todos, seduzindo e inquirindo aos eleitores que votem em determinado candidato ou partido. Mas, em meio a tantos apelos, qual me fortalece como cidadão e devo me render ou atender? O presente estudo teve como objetivo proporcionar ao leitor um entendimento mais aprofundado e perceptivo do material que é apresentado no Horário Gratuito Político Eleitoral - HGPE. A abordagem realiza-se dentro de uma visão qualitativa e quantitativa, compreendendo um movimento reflexivo e crítico, objetivando investigar o que é Marketing Político x Marketing Eleitoral e como estes, usados no HGPE, aumentam ou diminuem os elementos que constroem o eleitor como cidadão político.
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Lima, Alice Marina lira. "Guerreiras, maternais e profissionais - candidatas à presidência do Brasil no HGPE televisivo." reponame:Repositório Institucional da UFPR, 2017. http://hdl.handle.net/1884/47990.

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Orientadora: Profa. Dra. Luciana Panke
Dissertação (mestrado) - Universidade Federal do Parana, Setor de Artes, Comunicação e Design, Programa de Pós-Graduação em Comunicação. Defesa: Curitiba, 23/03/2017
Inclui referências : f. 113-122
Resumo: A pesquisa tem como tema o feminino sob o viés da comunicação política e eleitoral. O objetivo é identificar imagens de candidatas no Horário Gratuito de Propaganda Eleitoral (HGPE) de todas as mulheres que disputaram a presidência do Brasil. Entre os anos de 1989 e 2014, sete participaram dos pleitos. Assim, o problema de pesquisa é: de que maneira as candidatas à presidência do Brasil se apresentaram no HGPE de acordo com perfis considerados ideais, elaborados por Luciana Panke (2015), que são a guerreira, a maternal e a profissional? Para responder à pergunta, abordam-se conceitos e pesquisas de gênero que entendem o termo enquanto construção social e cultural de identidades (LAMAS, 2013; SCOTT, 1995; PANKE, 2015). Autores como Luís Felipe Miguel e Flávia Biroli (2011; 2014), e Panke (2015; 2016) discorrem sobre as características da relação entre mulheres e política, suas representações, tendências e desafios. Para a contextualização sobre comunicação política e eleitoral, são adotados trabalhos como os de Afonso Albuquerque (2004) e Panke (2010; 2011). Já na etapa empírica, a partir do método de análise de conteúdo, busca-se identificar os perfis de candidaturas femininas sistematizados por Panke (2015): a guerreira, a maternal e a profissional. A pesquisa verificou que a primeira é a que mais se destaca entre as candidatas, em média, em 50% do tempo. Em seguida, a maternal, com 29% e, em menor quantidade, a profissional - 21%. Embora possuam características, estruturas de campanha e partidos diferentes, diversas semelhanças foram encontradas na comunicação projetada por essas candidatas. O argumento de que a mulher tem uma forma diferente de fazer política e o apelo à questão de gênero foram mais presentes entre as primeiras postulantes ao cargo, Lívia Maria Pio e Thereza Ruiz. Contudo, alguns posicionamentos que buscam levar características do espaço doméstico, com o qual as mulheres são relacionadas historicamente, à atividade pública, na qual está inserida a política, continuam presentes nas últimas campanhas realizadas no país, como nas da presidenta eleita em 2010 e reeleita em 2014, Dilma Rousseff. Palavras-chave: Comunicação Política. Mulheres. HGPE. Eleições. Candidatas presidenciais.
Abstract: The research has the theme of females under the bias of political and electoral communication. The objective is to identify profiles of female candidates in the Free Political Advertising Time (description for Horário Gratuito de Propaganda Eleitoral, HPGE), of all those who disputed the presidency of Brazil. Between the years of 1989 and 2014, seven women participated in the election lawsuit. Thus, the research question is: how did the candidates for the Brazilian presidency present themselves in the HGPE according to profiles considered ideal, elaborated by Panke (2015), which are the brave, the maternal and the professional? To answer the question, the dissertation approaches concepts and gender research that understand the term as a social construction and culture of identities (LAMAS, 2013; SCOTT, 1995; PANKE, 2015). Authors such as Luís Felipe Miguel and Flávia Biroli (2011, 2014), and Luciana Panke (2015, 2016) write about the characteristics of the relationship between women and politics - their representations, trends and challenges. For the contextualization on political and electoral communication, works like those from Afonso Albuquerque (2004) and Panke (2010; 2011) are adopted. In contrast, in the empirical stage, from the method of content analysis, it is sought to identify profiles of female applications systematized by Panke (2015): the brave; the maternal; and the professional. The research identified that the first is the one that stands out among the candidates, on average, in 50% of the time. Then, the maternal, with 29% and, to a lesser extent, the professional - 21%. Although they have characteristics, campaign structures and different parties, several similarities were found in the images projected by these candidates. The argument that women have a different way of doing politics and appealing to the gender issue were more present among the first candidates, Lívia Maria Pio and Thereza Ruiz. However, some positions that seek to take characteristics of the domestic space with which women are historically related to the public activity in which the policy is inserted continue to be present in the last campaigns held in the country, such as those of the president elected in 2010 and re-elected In 2014, Dilma Rousseff. Keywords: Political Communication. Women. HGPE. Elections. Presidential female candidates.
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Shehab, Mahdi. "The effects of heavy goods vehicles (HGVs) on driver behaviour while car-following." Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439347.

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Books on the topic "HGPS"

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Clube Historia e Geografia de Portugal HGP5 (HGP5, 5 Ano). Porto Editora, 2003.

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Hgs-Kalottenmodelle - Grundbaukasten. Wiley-VCH, 1992.

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Hgs-Kalottenmodelle - Biochemie-Baukasten. Wiley-VCH, 1992.

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Abu-Zahra, Nadia. To HGIS or not to HGIS: What are the potential and actual applications in low- to middle-income countries of health-based geographic information systems (HGIS)? 2002, 2002.

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(NA), Not Available. HGS Molecular Structure Model Kit. Not Available (NA), 2001.

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NA. Longm Anth Brit Cmpct Vol B& Wuthering Hgts. Addison Wesley Publishing Company, 2005.

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Maruzen, Benjamin. Hgs Molecular Structure Models: Organic Chemistry. Addison Wesley Publishing Company, 1988.

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Wallis, Joanne, Lia Kent, Miranda Forsyth, Sinclair Dinnen, and Srinjoy Bose, eds. Hybridity on the Ground in Peacebuilding and Development: Critical Conversations. ANU Press, 2018. http://dx.doi.org/10.22459/hgpd.03.2018.

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HGS Molecular Structure Model Kit: Organic Chemistry : With Instruction Manual. W.H. Freeman & Company, 1998.

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Organic Chemistry: Includes Study Guide & Solutions Manual and HGS Molecular Structure Model. 4th ed. Oxford University Press, USA, 2002.

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Book chapters on the topic "HGPS"

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Padhy, Chinmaya Prasad, S. Suryakumar, and N. Raghunath Reddy. "Anatomy of a Fused Filament Fabrication (FFF) 3D Printing System for High-Grade Polymers (HGPs)—An Overview." In Lecture Notes in Mechanical Engineering, 179–96. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7787-8_13.

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Arnemann, J. "HGVS-Database." In Lexikon der Medizinischen Laboratoriumsdiagnostik, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_3501-1.

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Arnemann, J. "HGVS-Database." In Springer Reference Medizin, 1111. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_3501.

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Chu, J. "HgS: resistivity." In New Data and Updates for III-V, II-VI and I-VII Compounds, 395. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-92140-0_290.

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Chu, J. "HgS: conductivity." In New Data and Updates for III-V, II-VI and I-VII Compounds, 393–94. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-92140-0_289.

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Villars, P., K. Cenzual, J. Daams, R. Gladyshevskii, O. Shcherban, V. Dubenskyy, V. Kuprysyuk, and I. Savysyuk. "HgS α." In Structure Types. Part 8: Space Groups (156) P3m1 – (148) R-3, 415. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-70892-6_216.

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Strauch, D. "HgS: enthalpy." In Landolt-Börnstein - Group III Condensed Matter, 199. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-23415-6_117.

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Chu, J. "HgS: energy gaps." In New Data and Updates for III-V, II-VI and I-VII Compounds, 392. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-92140-0_288.

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Strauch, D. "HgS: phase transitions." In Landolt-Börnstein - Group III Condensed Matter, 197–98. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-23415-6_116.

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Strauch, D. "HgS: lattice parameters." In Landolt-Börnstein - Group III Condensed Matter, 200–202. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-23415-6_118.

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Conference papers on the topic "HGPS"

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Al-Taq, Ali, Luai Alhmad, Abdullah Alrustum, and Sajjad Aldarweesh. "Hydrogels for Water Shut-Off Treatments: Evaluation of a New Polymer Gel System." In SPE Conference at Oman Petroleum & Energy Show. SPE, 2022. http://dx.doi.org/10.2118/200041-ms.

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Abstract Hydrogel polymers have served the oil and gas industry in different applications including water shot-off. Hydrogel polymers can create impermeable gels to optimize water injection profile, improve sweep efficiency, and seal undesirable permeable zones. They have been successfully applied as remediation treatments to control water production from thief zones, natural fractures, and matrix formation. In this study, a new hydrogel polymer system (HGPS) was examined for water control treatments in sandstone formations. The experimental work included swelling testing, viscosity measurements, and coreflood experiments. The effects of water salinity, HGPS concentrations, pH values and temperature on examined HGPS properties were investigated. The HGPS concentrations examined in this study ranged between 0.3 to 2%, while water salinity ranged from 20,000 to 250,000 mg/L of NaCl. The examined pH values were between 7 and 1 and the temperatures ranged from ambient to 90°C. The coreflood experiments were conducted at 80°C using sandstone core plugs. The results showed that the viscosity of the HGPS increased with concentration and temperature but decreased with water salinity. The viscosity of the HGPS at 1.5 wt% and at a temperature of 60°C decreased from 575 to 16 cP when the pH value was decreased from 7 to 1. The results also demonstrated that the salinity had a negative impact on swelling properties and, eventually, the HGPS viscosity. Coreflood experiments showed that the HGPS should be squeezed into the core plug at higher injection rates (below frac pressure) in order to achieve high water control. The residual resistant factor to water obtained at an injection rate of 5 cm3/min was 158 while it was found to be &lt; 5 at an injection rate of 1 cm3/min. At lower injecting rate, the HGPS was found to form an external filtercake at the inlet face of the core plug. The paper presents in detail the major lab findings of the evaluation of a newly developed hydrogel polymer system and recommends the optimum conditions to control water production successfully.
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Usune, Yoshie, Masahiko Onda, Yasuoki Tomita, and Balaji Jayaraj. "OEM’s Approach to Maintain High Reliability of Hot Gas Path Parts." In ASME Turbo Expo 2010: Power for Land, Sea, and Air. ASMEDC, 2010. http://dx.doi.org/10.1115/gt2010-23241.

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The reliability of gas turbine (GT) Hot Gas Path components requires both design and metallurgical expertise. There are numerous repair facilities around the world with general metallurgical expertise. However, the maintenance process can be noticeably improved through a feedback approach that incorporates the original part design know-how and the fleet wide experience gathered from operational data. A lot of users apply daily start-stop cycles so these peaking operations will impose more severe duties on the hot gas path parts (HGPPs). For this reason, we have achieved high GT reliability, low fall out rate, and improved repair processes utilizing our in-house verification plant (combined power plant of G class GT). For service units, the Remote Monitoring concept [1] was developed to provide an extra level of protection and diagnostics for power generation equipment and it has also facilitated correlation between HGPPs distress and operational profiles. The use of historical operating data, including number of cycles, trips, and rapid load changes can reveal valuable information on the HGPPs distress and assist repair process improvement. Fleet database can give lots of feedback on the reliability and durability of the repaired components. This paper describes our own process of improving HGPP design and feedback to the maintenance. This process includes analysis of thermal barrier coating (TBC) degradation, careful application of life assessment techniques on substrate metallurgy, and analysis of operational data to improve design and repair techniques for increasing fleet availability.
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Gerber, R., D. R. Kelland, and M. Takayasu. "Collision effects in axial HGMs." In International Magnetics Conference. IEEE, 1989. http://dx.doi.org/10.1109/intmag.1989.690180.

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Lawson, P., and R. Gerber. "Viscosity effects in multi-wire HGMS." In International Conference on Magnetics. IEEE, 1990. http://dx.doi.org/10.1109/intmag.1990.734449.

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Gerber, R., and P. Lawson. "The HGMS filter performance exponential law." In International Magnetics Conference. IEEE, 1989. http://dx.doi.org/10.1109/intmag.1989.690182.

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Blaurock, Carl, Kuo-Chia Liu, and Peter Mule. "Solar Dynamics Observatory (SDO) HGAS Induced Jitter." In 49th AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference
16th AIAA/ASME/AHS Adaptive Structures Conference
10t. Reston, Virigina: American Institute of Aeronautics and Astronautics, 2008. http://dx.doi.org/10.2514/6.2008-1951.

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Tae-Kyung Kim, Sang-Keun Oh, Kyung-Hee Lee, Dong-Hyun Roh, and Wan-Sup Cho. "HGBS: a hardware-oriented grid BLAST system." In CCGrid 2005. IEEE International Symposium on Cluster Computing and the Grid, 2005. IEEE, 2005. http://dx.doi.org/10.1109/ccgrid.2005.1558597.

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Zainuddin, Shaik, Arefin Tauhid, Mahesh V. Hosur, Shaik Jeelani, and Ashok Kumar. "Recovery of Low-Velocity Impact Properties of Glass Fiber Reinforced Composites Through Self-Healing Technique." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-66771.

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In this study, we report the self-healing of e-glass/epoxy composites achieved through embedding self-healing agents (SHA) filled hollow glass fibers (HGFs). At first, catalytic technique was used to fill bonded HGFs with SHA. The HGFs were then laid on e-glass fibers and the laminates were fabricated using vacuum assisted resin molding (VARIM) technique. Low-velocity impact tests at two different energy levels were conducted multiple times in the closest proximity to determine the healing efficiency. Optical microscopic study was done to see the changes in the SHA filled HGFs samples before and after impact. Results showed significant recovery of impact properties with 4.47% lost in peak load after second impact in SHA samples whereas it was 27.7% in control samples. The loss in energy to peak load was 20.44% in SHA filled samples, whereas 41% in control samples. Optical microscopy images showed filling of cracks produced after impact with SHA reflecting the significant recovery of impact properties.
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Song, Kee-Nam, and Yong-Wan Kim. "Preliminary Design Analysis of a Hot Gas Ducts for the Nuclear Hydrogen System." In 16th International Conference on Nuclear Engineering. ASMEDC, 2008. http://dx.doi.org/10.1115/icone16-48145.

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Korea Atomic Energy Research Institute (KAERI) is in the process of carrying out a nuclear hydrogen system by considering the indirect cycle gas cooled reactors that produce heat at temperatures in the order of 950 °C. A coaxial double-tube hot gas duct (HGD) is a key component connecting the reactor pressure vessel and the intermediate heat exchanger (IHX) for the nuclear hydrogen system. Recently, a preliminary design analysis for the primary and secondary hot gas ducts of the nuclear hydrogen system was carried out. These preliminary design activities include a preliminary decision on the geometric dimensions, a preliminary strength evaluation and an appropriate material selection. In this study, a preliminary strength evaluation for the HGDs of the nuclear hydrogen system has been undertaken. Preliminary strength evaluation results for the HGDs showed that the geometric dimensions of the proposed HGDs would be acceptable for the design requirements.
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Chen, Peng, and Bin Wang. "Finite Time Control of a Fractional Order Hydro-Turbine Governing System With Load Rejection." In ASME 2021 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/detc2021-67359.

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Abstract This study focuses on the finite time control of a fractional order hydro-turbine governing system (HGS) with load rejection. First, the hydraulic servo system has significant historical reliance. Since it is a powerful advantage for fractional calculus to describe the function which has significant historical reliance, the fractional order hydraulic servo system is adopted and the more actual fractional order hydro-turbine governing system is presented. Second, some definitions and properties are given, and the state trajectories of HGS with load rejection is observed. The simulation results show that the state trajectory of the system is not stable, so it is necessary to design a controller with better control effect. Third, based on the frequency distribution model, the equivalent transformation model of HGS is presented. A new finite time sliding mode control scheme is proposed for the stability control of the HGS with load rejection. Furthermore, the no chattering sliding mode controller and its detailed mathematical derivation are given. The system stability is proved, and the upper limit of HGS finite time stability is given. Finally, numerical simulations have verified the theoretical results. The controller can make the state trajectories of the HGS converge to zero in a finite time, and the control time is very short.
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Reports on the topic "HGPS"

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Lipinska, Kris, and Oliver Hemmers. HGMS: Glasses and Nanocomposites for Hydrogen Storage. Office of Scientific and Technical Information (OSTI), February 2013. http://dx.doi.org/10.2172/1063116.

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Anderson, H. L., S. D. Balsley, and P. V. Brady. Iodide retention by cinnabar (HgS) and chalcocite (Cu{sub 2}S). Office of Scientific and Technical Information (OSTI), July 1995. http://dx.doi.org/10.2172/97329.

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Thomas, Donald M. The Geochemistry of the HGP-A Geothermal Well: A Review and an Update. Office of Scientific and Technical Information (OSTI), January 1988. http://dx.doi.org/10.2172/882392.

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De Carlo, E. H. Chemical behaviour of geothermal silica after precipitation from geothermal fluids with inorganic flocculating agents at the Hawaii Geothermal Project Well-A (HGP-A). Office of Scientific and Technical Information (OSTI), January 1987. http://dx.doi.org/10.2172/6784371.

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Dubcovsky, Jorge, Tzion Fahima, and Ann Blechl. Positional cloning of a gene responsible for high grain protein content in tetraploid wheat. United States Department of Agriculture, September 2003. http://dx.doi.org/10.32747/2003.7695875.bard.

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High Grain Protein Content (GPC) is a desirable trait in breadmaking and pasta wheat varieties because of its positive effects on quality and nutritional value. However, selection for GPC is limited by our poor understanding of the genes involved in the accumulation of protein in the grain. The long-term goal of this project is to provide a better understanding of the genes controlling GPC in wheat. The specific objectives of this project were: a) to develop a high-density genetic map of the GPC gene in tetraploid wheat, b) to construct a T. turgidum Bacterial Artificial Chromosome (BAC) library, c) to construct a physical map of the GPC gene and identify a candidate for the GPC gene. A gene with a large effect on GPC was detected in Triticum turgidum var. dicoccoides and was previously mapped in the short arm of chromosome 6B. To define better the position of the Gpc-B1 locus we developed homozygous recombinant lines with recombination events within the QTL region. Except for the 30-cM region of the QTL these RSLs were isogenic for the rest of the genome minimizing the genetic variability. To minimize the environmental variability the RSLs were characterized using 10 replications in field experiments organized in a Randomized Complete Block Design, which were repeated three times. Using this strategy, we were able to map this QTL as a single Mendelian locus (Gpc-B1) on a 2.6-cM region flanked by RFLP markers Xcdo365 and Xucw67. All three experiments showed that the lines carrying the DIC allele had an average absolute increase in GPC of 14 g/kg. Using the RFLP flanking markers, we established the microcolinearity between a 2.l-cM region including the Gpc-B1 gene in wheat chromosome 6BS and a 350-kb region on rice chromosome 2. Rice genes from this region were used to screen the Triticeae EST collection, and these ESTs were used to saturate the Gpc-B1 region with molecular markers. With these new markers we were able to map the Gpc-B1 locus within a 0.3-cM region flanked by PCR markers Xucw83 and Xucw71. These flanking markers defined a 36-kb colinear region with rice, including one gene that is a potential candidate for the Gpc-B1 gene. To develop a physical map of the Gpc-B1 region in wheat we first constructed a BAC library of tetraploid wheat, from RSL#65 including the high Gpc-B1 allele. We generated half- million clones with an average size of l3l-kb (5.1 X genome equivalents for each of the two genomes). This coverage provides a 99.4% probability of recovering any gene from durum wheat. We used the Gpc-BI flanking markers to screen this BAC library and then completed the physical map by chromosome walking. The physical map included two overlapping BACs covering a region of approximately 250-kb, including two flanking markers and the Gpc-B1 gene. Efforts are underway to sequence these two BACs to determine if additional wheat genes are present in this region. Weare also developing new RSLs to further dissect this region. We developed PCR markers for flanking loci Xucw79andXucw71 to facilitate the introgression of this gene in commercial varieties by marker assisted selection (httQ://maswheat.ucdavis.edu/ orotocols/HGPC/index.hlm). Using these markers we introgressed the Gpc-B1 gene in numerous pasta and common wheat breeding lines.
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An information and dialogue conference on the human genome project (HGP) for the minority communities in the state of Louisiana. Office of Scientific and Technical Information (OSTI), June 1999. http://dx.doi.org/10.2172/770634.

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