To see the other types of publications on this topic, follow the link: HIC.
Journal articles on the topic 'HIC'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'HIC.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Harrison, Robert Pogue. "Hic Jacet." Critical Inquiry 27, no. 3 (April 2001): 393–407. http://dx.doi.org/10.1086/449014.
Full text
2
Conze, Eckart. "Hic sunt leones." Historische Anthropologie 10, no. 2 (August 2002): 295–99. http://dx.doi.org/10.7788/ha.2002.10.2.295.
Full text
3
Göttel, Dennis. "Hic sunt leones." Maske und Kothurn 56, no. 2 (June 2010): 11–24. http://dx.doi.org/10.7767/muk.2010.56.2.11.
Full text
4
Weil-Malherbe, Hans. "Hic, Haec, Hoc . . ." Science 232, no. 4752 (May 16, 1986): 811. http://dx.doi.org/10.1126/science.232.4752.811.a.
Full text
5
Scherr, Elisabeth, and Arne Ziegler. "Hic et ibi." Linguistik Online 110, no. 5 (October 19, 2021): 3–8. http://dx.doi.org/10.13092/lo.110.8101.
Full textAbstract:
Even though spacious conditions are integral parts of the vast majority of studies in the fields of sociolinguistics and variationist linguistics, they are not always discussed as subject matters per se. The special issue In Stadt und Land – Perspektiven variations- und soziolinguistischer Forschung aims at uniting different approaches that construe spatial categories not as sheer preconditions for the assignment of linguistic features or for the drawing up of maps but as central parameters in the analyses. The contributions thus illustrate one of the current trends in sociolinguistic and variationist linguistic research to explicitly discuss, conceptualize and systematize spatial categories.
6
LENTINI, Gabrielle. "Hic Sunt Leones?" Journal of the European Society of Women in Theological Research 9 (January 1, 2001): 137–61. http://dx.doi.org/10.2143/eswtr.9.0.2002911.
Full text
7
Carrera, Arturo. "Hic Sunt Leones." Journal of Latin American Cultural Studies 18, no. 1 (March 2009): 5. http://dx.doi.org/10.1080/13569320902819463.
Full text
8
Salatowsky, Sascha. "Dic cur hic?" Bochumer Philosophisches Jahrbuch für Antike und Mittelalter 11 (December 31, 2006): 103–58. http://dx.doi.org/10.1075/bpjam.11.07sal.
Full textAbstract:
In order to attain a deeper understanding of Aristotelian philosophy in the Renaissance, it is necessary to consider the theological implications of given facts. This article discusses a basic problem centring on the reception of Aristotle’s Ethics. The Nicomachean Ethics was widely regarded as the basis for a virtuous ethical life, yet how could a pagan philosophy, with its concepts of happiness, virtue, justice, etc., be the basis of a Christian society? The aim of the present article is to show how Lutheran scholars solved this problem in confrontation with Catholic and Calvinist scholars of the time. The first part deals with the two basic components of Aristotle’s Ethics, namely the doctrines of happiness (Eudaimonologia) and virtue (Aretologia), and attempts to show that Aristotle’s Ethics should not be understood as a system of rules, but rather as a handbook for the cultivation of practical habits in the free human being who strives to live a good life. The second part examines two key ideological confrontations in relation to Aristotle’s philosophy: between Lutherans and Calvinists in respect of definition of theology and philosophical and theological virtues on the one hand, and between Lutherans and ›the Enthusiasts‹ in respect of the concept of virtues on the other.
9
Chazaud, J. "Hic et nunc." L'Évolution Psychiatrique 65, no. 2 (April 2000): 395–407. http://dx.doi.org/10.1016/s0014-3855(00)80014-6.
Full text
10
Andrieu, B. "Hic et nunc." L'Évolution Psychiatrique 65, no. 2 (April 2000): 409–20. http://dx.doi.org/10.1016/s0014-3855(00)80015-8.
Full text
11
Izcovich, L. "Hic et nunc." L'Évolution Psychiatrique 66, no. 1 (January 2001): 122–32. http://dx.doi.org/10.1016/s0014-3855(01)90011-8.
Full text
12
Birmes, P., and L. Schmitt. "Hic et nunc." L'Évolution Psychiatrique 64, no. 2 (April 1999): 399–409. http://dx.doi.org/10.1016/s0014-3855(99)80078-4.
Full text
13
Gaudriault, P. "Hic et nunc." L'Évolution Psychiatrique 64, no. 2 (April 1999): 425–31. http://dx.doi.org/10.1016/s0014-3855(99)80080-2.
Full text
14
WEIL-MALHERBE, H. "Hic, Haec, Hoc .." Science 232, no. 4752 (May 16, 1986): 811. http://dx.doi.org/10.1126/science.232.4752.811.
Full text
15
Culyer, Anthony J. "Hic Sunt Dracones." Medical Decision Making 32, no. 1 (November 18, 2011): E25—E32. http://dx.doi.org/10.1177/0272989x11426483.
Full text
16
Borgy, Jacques. "Hic et nunc !" Psychologues et Psychologies N°247, no. 5 (January 6, 2016): 3. http://dx.doi.org/10.3917/pep.247.0003.
Full text
17
Iams, Wade Thomas, Kimberly Le, Nicole Princic, and Taylor Marlin. "Real-world healthcare resource utilization amongst non-small cell lung cancer (NSCLC) patients tested with a host immune classifier (HIC)." Journal of Clinical Oncology 41, no. 16_suppl (June 1, 2023): e21210-e21210. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e21210.
Full textAbstract:
e21210 Background: The HIC is a blood-based proteomic test that measures immune response in patients with NSCLC. The test stratifies patients into two groups, HIC-H and HIC-C which helps evaluate patient prognosis and response to treatment. While clinical validity of the HIC test has been published, no real-world studies have described healthcare resource utilization (HCRU) amongst patients who have been tested with the HIC. This claims analysis describes HCRU amongst patients with NSCLC tested with the HIC. Methods: MarketScan Commercial and Medicare Supplemental Databases linked to Biodesix data files of HIC test results were retrospectively queried to identify patients who were age 18 and older on index date (date of HIC testing), underwent a HIC proteomic test, were continuously enrolled in the MarketScan database for the 6-months before index (pre-index period) and one month post-index, and had at least one non-diagnostic medical claim of lung cancer during the pre-index period. Data utilized was between January 1, 2016 to June 30, 2021. HCRU was measured per patient per month (PPPM) during the pre-index and post-index period and compared between HIC-H and HIC-C cohorts. Results: Of the 328 included patients, 260 patients were HIC-H and 68 were HIC-C. On index, 178 patients had non-metastatic lung cancer and 150 patients had metastatic lung cancer. When examining HCRU in all patients prior to the HIC test, significantly more HIC-C patients had an outpatient visit with an oncologist (40% vs 27%, P < 0.05) or a primary care physician (71% vs 56%, P < 0.05). When assessing only patients with metastatic lung cancer prior to index, significantly more HIC-C patients had inpatient admissions (57% vs 37%, P < 0.05) and more outpatient visits with a primary care physician (73% vs 50%, P < 0.05). When examining HCRU in patients after the HIC test, metastatic patients had significantly more prescriptions (4.6 vs 3.6, P < 0.05). Metastatic HIC-H patients also had significantly more visits to the emergency room (64% vs 43%, P < 0.05). Conclusions: Patients who are identified as HIC-C tend to have higher HCRU earlier in their lung cancer diagnosis and treatment course (prior to HIC testing). In the post-index period, metastatic HIC-H patients had higher HCRU with respect to prescriptions and emergency visits. Other post-index HCRU metrics such as primary care utilization and inpatient admissions were similar among HIC-C and HIC-H patients. Earlier identification of HIC-C and HIC-H patients may help identify those most likely to benefit from additional health system navigation support.
18
Fujishiro, Taishi, and Takuya Hara. "In Situ Observation of Hydrogen-Induced Cracking Propagation Behavior." Corrosion 74, no. 10 (June 16, 2018): 1054–62. http://dx.doi.org/10.5006/2757.
Full textAbstract:
Hydrogen-induced cracking (HIC) is one of the major issues of line pipe exposed to sour environments. There are some guidelines on materials requirements for carbon and low alloy steels for H2S-containing environments in oil and gas production. Generally, HIC susceptibility is evaluated after the test duration, typically 96 h, in accordance with NACE Standard TM0284-2016. However, HIC propagation behavior during HIC test has not been fully understood. In this study, a new in situ HIC measurement method has been developed in order to make the connection between HIC propagation behavior and microstructure. This technique is based on the combination of an automatic ultrasonic wave inspection system and a scanning electron microscopy (SEM) observation. HIC propagation rate and HIC propagation behavior of carbon steels with different textures were investigated, using this in situ technique. Texture components of tested steels were changed by controlled rolling process in the alpha-gamma dual phase region. The {100} intensity parallel to the rolling plane was developed with increasing controlled rolling reduction in the alpha-gamma dual phase region. HIC propagation rate increased and crack length of HIC grew in a staircase pattern with time when the {100} texture was highly developed. In addition, HIC propagation behavior could be overlapped with fracture surface, just like a projection mapping. The overlapping could make the connection between HIC propagation behavior and HIC fracture surface. Microstructure and texture just under the HIC fracture surface was also characterized by SEM and an electron backscatter diffraction pattern method. The results obtained in this study showed that HIC propagation behavior was affected by a texture. In addition, the new in situ HIC observation technique, which can make the direct connection between HIC propagation behavior and microstructure, revealed a detailed HIC propagation behavior and an effect of microstructure.
19
Okura, Tsuyoshi, Yohei Fujioka, Risa Nakamura, Mari Anno, Yuichi Ito, Sonoko Kitao, Kazuhisa Matsumoto, et al. "Hepatic insulin clearance is increased in patients with high HbA1c type 2 diabetes: a preliminary report." BMJ Open Diabetes Research & Care 8, no. 1 (April 2020): e001149. http://dx.doi.org/10.1136/bmjdrc-2019-001149.
Full textAbstract:
IntroductionHepatic insulin clearance (HIC) is an important pathophysiology of type 2 diabetes. HIC was reported to decrease in patients with type 2 diabetes and metabolic syndrome. However, hyperglycemia was suggested to enhance HIC, and it is not known whether poorly controlled diabetes increases HIC in patients with type 2 diabetes. We investigated whether HIC was increased in patients with poorly controlled diabetes, and whether HIC was associated with insulin resistance and incretins.Research design and methodsWe performed a meal tolerance test and the hyperinsulinemic–euglycemic clamp in 21 patients with type 2 diabetes. We calculated the postprandial C-peptide area under the curve (AUC)-to-insulin AUC ratio as the HIC; measured fasting and postprandial glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon levels and analyzed serum adiponectin and zinc transporter-8 (ZnT8) gene polymorphism.ResultsThe HIC significantly correlated with glycated hemoglobin (HbA1c) (r_S=0.58, p<0.01). In patients with high HIC above the median of 6.5, the mean HbA1c was significantly higher compared with low HIC below the median. Homeostatic model assessment (HOMA)-beta (r_S=−0.77, p<0.01) and HOMA-IR (r_S=−0.66, p<0.005) were correlated with HIC. The M/I value in the clamp study was correlated with HIC. GLP-1-AUC and GIP-AUC were not correlated with HIC. Glucagon-AUC was negatively correlated with HIC, but there were no significant differences between the high and low HIC groups. Adiponectin was positively correlated with HIC. The ZnT8 gene polymorphism did not affect HIC.ConclusionsThese results suggest that HIC was increased in patients with high HbA1c type 2 diabetes, low insulin secretion, low insulin resistance and high adiponectin conditions.
20
Iams, Wade Thomas, Kimberly Le, Nicole Princic, and Taylor Marlin. "Real-world healthcare costs amongst non-small cell lung cancer (NSCLC) patients tested with a host immune classifier (HIC)." Journal of Clinical Oncology 41, no. 16_suppl (June 1, 2023): e21187-e21187. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e21187.
Full textAbstract:
e21187 Background: The HIC is a proteomic test that measures immune response in patients diagnosed with NSCLC. The blood based HIC stratifies patients into two groups, HIC-H and HIC-C which helps evaluate the patient’s prognosis and response to treatment. Currently, no real-world studies have described healthcare costs amongst patients tested with the HIC. This subset analysis of HIC claims examined costs among patients with NSCLC prior to and after using the HIC proteomic test. Methods: HIC test results were retrospectively queried using MarketScan Commercial and Medicare Supplemental Databases using data between January 1, 2016 to June 30, 2021 linked to Biodesix data files. Patients were included if they were age 18 and older on index date (date of HIC testing), underwent a HIC proteomic test, were continuously enrolled in the MarketScan database for the 6-months before index (pre-index period) and one month post-index, and had at least one non-diagnostic medical claim of lung cancer during the pre-index period. Healthcare costs were measured per patient per month (PPPM) during the pre-index and post-index period and compared between HIC-H and HIC-C cohorts. All-cause healthcare costs analyzed included inpatient costs, outpatient costs, outpatient pharmacy costs, total medical costs (inpatient + outpatient), and total costs (total medical + outpatient pharmacy). Results: Of the 328 included patients, 260 patients were HIC-H and 68 were HIC-C. On index, 178 patients had non-metastatic lung cancer and 150 patients had metastatic lung cancer. When examining healthcare costs prior to HIC testing, total costs and inpatient costs were higher amongst HIC-C patients ($10,299 vs $9,689 and $4,032 vs $3,218, respectively) although not statistically significant. HIC-C patients had significantly higher biopsy costs compared to HIC-H patients ($1,285 vs $400, P < 0.05) even though less HIC-C patients underwent a lung biopsy (41% vs 53%, P = 0.091). When assessing healthcare costs post HIC testing, total medical costs were significantly higher in the HIC-C patients ($25,255 vs $17,210, P < 0.05). Although not statistically significant, HIC-C patients had higher inpatient costs and total costs ($9,903 vs $5,583 and $26,237 vs $18,652, respectively). Amongst the patients had significantly higher inpatient costs ($18,580 vs $4,278, P < 0.05), total medical costs ($29,574 vs $12,446, P < 0.05) and total costs ($31,316 vs $13,500, P < 0.05). Conclusions: Patients with NSCLC who are identified as HIC-C have higher healthcare costs, including lung cancer diagnostic and total costs, prior to and post HIC testing. Utilization of the HIC test may help to identify patients who may benefit from additional health system navigation support to mitigate their anticipated increased health care costs.
21
Avraamides, C., M. E. Bromberg, J. P. Gaughan, S. M. Thomas, A. Y. Tsygankov, and T. S. Panetti. "Hic-5 promotes endothelial cell migration to lysophosphatidic acid." American Journal of Physiology-Heart and Circulatory Physiology 293, no. 1 (July 2007): H193—H203. http://dx.doi.org/10.1152/ajpheart.00728.2006.
Full textAbstract:
Endothelial cell migration is critical for proper blood vessel development. Signals from growth factors and matrix proteins are integrated through focal adhesion proteins to alter cell migration. Hydrogen peroxide-inducible clone 5 (Hic-5), a paxillin family member, is enriched in the focal adhesions in bovine pulmonary artery endothelial (BPAE) cells, which migrate to lysophosphatidic acid (LPA) on denatured collagen. In this study, we investigate the role of Hic-5 in LPA-stimulated endothelial cell migration. LPA recruits Hic-5 to the focal adhesions and to the pseudopodia in BPAE cells plated on collagen, suggesting that recruitment of Hic-5 to focal adhesions is associated with endothelial cell migration. Knockdown of endogenous Hic-5 significantly decreases migration toward LPA, confirming involvement of Hic-5 in migration. To address the role of Hic-5 in endothelial cell migration, we exogenously expressed wild-type (WT) Hic-5 and green fluorescent protein Hic-5 C369A/C372A (LIM3 mutant) constructs in BPAE cells. WT Hic-5 expression increases chemotaxis of BPAE cells to LPA, whereas migration toward LPA of the green fluorescent protein Hic-5 C369A/C372A-expressing cells is similar to that shown in vector control cells. Additionally, ERK phosphorylation is enhanced in the presence of LPA in WT Hic-5 cells. A pharmacological inhibitor of MEK activity inhibits LPA-stimulated WT Hic-5 cell migration and ERK phosphorylation, suggesting Hic-5 enhances migration via MEK activation of ERK. Together, these studies indicate that Hic-5, a focal adhesion protein in endothelial cells, is recruited to the pseudopodia in the presence of LPA and enhances migration.
22
Emond, Mary J., Mary P. Bronner, Timothy H. Carlson, Masami Lin, Robert F. Labbe, and Kris V. Kowdley. "Quantitative Study of the Variability of Hepatic Iron Concentrations." Clinical Chemistry 45, no. 3 (March 1, 1999): 340–46. http://dx.doi.org/10.1093/clinchem/45.3.340.
Full textAbstract:
Abstract Background: The hepatic iron concentration (HIC) is widely used in clinical practice and in research; however, data on the variability of HIC among biopsy sites are limited. One aim of the present study was to determine the variability of HIC within both healthy and cirrhotic livers. Methods: Using colorimetric methods, we determined HIC in multiple large (microtome) and small (biopsy-sized) paraffin-embedded samples in 11 resected livers with end-stage cirrhosis. HIC was also measured in multiple fresh samples taken within 5 mm of each other (“local” samples) and taken at sites 3–5 cm apart (“remote” samples) from six livers with end-stage cirrhosis and two healthy autopsy livers. Results: The within-organ SD of HIC was 13–1553 μg/g (CV, 3.6–55%) for microtome samples and 60–2851 μg/g (CV, 15–73%) for biopsy-sized samples. High variability of HIC was associated with mild to moderate iron overload, because the HIC SD increased with increasing mean HIC (P <0.002). Livers with mean HIC >1000 μg/g exhibited significant biological variability in HIC between sites separated by 3–5 cm (remote sites; P <0.05). The SD was larger for biopsy-sized samples than for microtome samples (P = 0.02). Conclusion: Ideally, multiple hepatic sites would be sampled to obtain a representative mean HIC.
23
Piera-Velazquez, Sonsoles, Jolanta Fertala, Gonzalo Huaman-Vargas, Natalia Louneva, and Sergio A. Jiménez. "Increased expression of the transforming growth factor β–inducible gene HIC-5 in systemic sclerosis skin and fibroblasts: a novel antifibrotic therapeutic target." Rheumatology 59, no. 10 (May 23, 2020): 3092–98. http://dx.doi.org/10.1093/rheumatology/keaa200.
Full textAbstract:
Abstract Objective SSc is a systemic fibrotic disease affecting skin, numerous internal organs and the microvasculature. The molecular pathogenesis of SSc tissue fibrosis has not been fully elucidated, although TGF-β1 plays a crucial role. The Hic-5 protein encoded by the TGF-β1-inducible HIC-5 gene participates in numerous TGF-β-mediated pathways, however, the role of Hic-5 in SSc fibrosis has not been investigated. The aim of this study was to examine HIC-5 involvement in SSc tissue fibrosis. Methods Affected skin from three patients with diffuse SSc and dermal fibroblasts cultured from affected and non-affected SSc skin were examined for HIC-5 and COL1A1 gene expression. Real-time PCR, IF microscopy, western blotting and small interfering RNA–mediated HIC-5 were performed. Results HIC-5 and COL1A1 transcripts and Hic-5, type 1 collagen (COL1) and α-smooth muscle actin (α-SMA) protein levels were increased in clinically affected SSc skin compared with normal skin and in cultured dermal fibroblasts from affected SSc skin compared with non-affected skin fibroblasts from the same patients. HIC-5 knockdown caused a marked reduction of COL1 production in SSc dermal fibroblasts. Conclusion HIC-5 expression is increased in affected SSc skin compared with skin from normal individuals. Affected SSc skin fibroblasts display increased HIC-5 and COL1A1 expression compared with non-affected skin fibroblasts from the same patients. Hic-5 protein was significantly increased in cultured SSc dermal fibroblasts. HIC-5 mRNA knockdown in SSc fibroblasts caused >50% reduction of COL1 production. Although these are preliminary results owing to the small number of skin samples studied, they indicate that Hic-5 plays a role in the profibrotic activation of SSc dermal fibroblasts and may represent a novel molecular target for antifibrotic therapy in SSc.
24
Iams, Wade, Kimberly Le, Nicole Princic, Isabelle Winer, and Taylor Marlin. "Abstract 942: Real-world demographics, baseline characteristics, healthcare resource utilization and costs amongst non-small cell lung cancer (NSCLC) patients tested with a Host Immune Classifier (HIC)." Cancer Research 83, no. 7_Supplement (April 4, 2023): 942. http://dx.doi.org/10.1158/1538-7445.am2023-942.
Full textAbstract:
Abstract Background: The Host Immune Classifier is a proteomic test that identifies a chronic inflammatory disease state for patients diagnosed with NSCLC. The test stratifies patients into two groups, HIC-H and HIC-C and helps evaluate patient prognosis and response to treatment. While much work has been done to evaluate the clinical validity of the HIC test, to date, no recent real-world studies have described healthcare resource utilization (HCRU) and costs amongst patients utilizing the test. This subset analysis of HIC claims examined demographic and baseline clinical characteristics among patients with lung cancer using the HIC proteomic test as well as HCRU and costs prior to test use. Methods: This retrospective claims analysis utilized MarketScan® Commercial and Medicare Supplemental Databases using data from January 1, 2016 to June 30, 2021 linked to Biodesix data files of HIC test results. Patients were age 18 or older on index date (date of HIC testing), underwent a HIC proteomic test, were continuously enrolled in the MarketScan database for the 6-months before index (pre-index period), and had at least one non-diagnostic medical claim of lung cancer during the pre-index period. Clinical characteristics and HCRU and costs were measured per patient per month (PPPM) during the pre-index period and compared between HIC-H and HIC-C cohorts. Results: Of the 328 included patients, 260 patients were HIC-H and 68 were HIC-C. On index, 178 patients had non-metastatic lung cancer and 150 patients had metastatic lung cancer. When assessing lung cancer related comorbid conditions, significantly more HIC-C patients had empyema (3% vs 0%, P<0.05) and pneumonia (34% vs 19%, P<0.05). When examining HCRU in patients prior to the HIC test, significantly more HIC-C patients had an outpatient visit with an oncologist (40% vs 27%, P<0.05) or a primary care physician (71% vs 56%, P<0.05). Total costs and inpatient costs were higher amongst HIC-C patients ($10,299 vs $9,689 and $4,032 vs $3,218, respectively) although not significant. While fewer HIC-C patients underwent lung biopsy (41% vs 53%), HIC-C patients had significantly higher biopsy costs than HIC-H patients ($1,285 vs $400, P<0.05). Although not statistically significant, more HIC-C patients had an inpatient admission (47% vs 38%) and longer average length of stay (5.3 vs 4.2 days). Conclusion: Patients with NSCLC who are identified as HIC-C have higher HCRU and costs, including lung cancer workup costs, prior to HIC testing. Further analyses are planned to determine long-term clinical outcomes, HCRU, and costs amongst patients post-testing. Citation Format: Wade Iams, Kimberly Le, Nicole Princic, Isabelle Winer, Taylor Marlin. Real-world demographics, baseline characteristics, healthcare resource utilization and costs amongst non-small cell lung cancer (NSCLC) patients tested with a Host Immune Classifier (HIC) [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 942.
25
Kohler, Sylvia, Teresia Hallström, Birendra Singh, Kristian Riesbeck, Giuseppina Spartà, Peter F. Zipfel, and Sven Hammerschmidt. "Binding of vitronectin and Factor H to Hic contributes to immune evasion of Streptococcus pneumoniae serotype 3." Thrombosis and Haemostasis 113, no. 01 (January 2015): 125–42. http://dx.doi.org/10.1160/th14-06-0561.
Full textAbstract:
SummaryStreptococcus pneumoniae serotype 3 strains are highly resistant to opsonophagocytosis due to recruitment of the complement inhibitor Factor H via Hic, a member of the pneumococcal surface protein C (PspC) family. In this study, we demonstrated that Hic also interacts with vitronectin, a fluid-phase regulator involved in haemostasis, angiogenesis, and the terminal complement cascade as well as a component of the extracellular matrix. Blocking of Hic by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In parallel, ectopic expression of Hic on the surface of Lactococcus lactis conferred binding to soluble and immobilised vitronectin as well as Factor H. Molecular analyses with truncated Hic fragments narrowed down the vitronectin-binding site to the central core of Hic (aa 151–201). This vitronectin-binding region is separate from that of Factor H, which binds to the N-terminus of Hic (aa 38–92). Binding of pneumococcal Hic was localised to the C-terminal heparin-binding domain (HBD3) of vitronectin. However, an N-terminal region to HBD3 was further involved in Hic-binding to immobilised vitronectin. Finally, vitronectin bound to Hic was functionally active and inhibited formation of the terminal complement complex. In conclusion, Hic interacts with vitronectin and simultaneously with Factor H, and both human proteins may contribute to colonisation and invasive disease caused by serotype 3 pneumococci.
26
Nishiya, Naoyuki, Kouichi Tachibana, Motoko Shibanuma, Jun-Ichi Mashimo, and Kiyoshi Nose. "Hic-5-Reduced Cell Spreading on Fibronectin: Competitive Effects between Paxillin and Hic-5 through Interaction with Focal Adhesion Kinase." Molecular and Cellular Biology 21, no. 16 (August 15, 2001): 5332–45. http://dx.doi.org/10.1128/mcb.21.16.5332-5345.2001.
Full textAbstract:
ABSTRACT Hic-5 is a paxillin homologue that is localized to focal adhesion complexes. Hic-5 and paxillin share structural homology and interacting factors such as focal adhesion kinase (FAK), Pyk2/CAKβ/RAFTK, and PTP-PEST. Here, we showed that Hic-5 inhibits integrin-mediated cell spreading on fibronectin in a competitive manner with paxillin in NIH 3T3 cells. The overexpression of Hic-5 sequestered FAK from paxillin, reduced tyrosine phosphorylation of paxillin and FAK, and prevented paxillin-Crk complex formation. In addition, Hic-5-mediated inhibition of spreading was not observed in mouse embryo fibroblasts (MEFs) derived from FAK−/− mice. The activity of c-Src following fibronectin stimulation was decreased by about 30% in Hic-5-expressing cells, and the effect of Hic-5 was restored by the overexpression of FAK and the constitutively active forms of Rho-family GTPases, Rac1 V12 and Cdc42 V12, but not RhoA V14. These observations suggested that Hic-5 inhibits cell spreading through competition with paxillin for FAK and subsequent prevention of downstream signal transduction. Moreover, expression of antisense Hic-5 increased spreading in primary MEFs. These results suggested that the counterbalance of paxillin and Hic-5 expression may be a novel mechanism regulating integrin-mediated signal transduction.
27
Yang, Lan, Jennifer Guerrero, Heng Hong, Donald B. DeFranco, and Michael R. Stallcup. "Interaction of the τ2 Transcriptional Activation Domain of Glucocorticoid Receptor with a Novel Steroid Receptor Coactivator, Hic-5, Which Localizes to Both Focal Adhesions and the Nuclear Matrix." Molecular Biology of the Cell 11, no. 6 (June 2000): 2007–18. http://dx.doi.org/10.1091/mbc.11.6.2007.
Full textAbstract:
Hic-5 (hydrogen peroxide–inducible clone-5) is a focal adhesion protein that is involved in cellular senescence. In the present study, a yeast two-hybrid screen identified Hic-5 as a protein that interacts with a region of the glucocorticoid receptor that includes a nuclear matrix–targeting signal and the τ2 transcriptional activation domain. In transiently transfected mammalian cells, overexpression of Hic-5 potentiated the activation of reporter genes by all steroid receptors, excluding the estrogen receptor. The activity of the estrogen receptor and the thyroid hormone receptor was stimulated by Hic-5 in the presence but not in the absence of coexpressed coactivator GRIP1. In biochemical fractionations and indirect immunofluorescence assays, a fraction of endogenous Hic-5 in REF-52 cells and transiently expressed Hic-5 in Cos-1 cells was associated with the nuclear matrix. The C-terminal region of Hic-5, which contains seven zinc fingers arranged in four LIM domains, was required for interaction with focal adhesions, the nuclear matrix, steroid receptors, and the τ2 domain of glucocorticoid receptor. The N-terminal region of Hic-5 possesses a transcriptional activation domain and was essential for the coactivator activity of Hic-5. Given the coexisting cytoplasmic and nuclear distributions of Hic-5 and its role in steroid receptor–mediated transcriptional activation, it is proposed that Hic-5 might transmit signals that emanate at cell attachment sites and regulate transcription factors, such as steroid receptors.
28
Shibanuma, Motoko, Joo-ri Kim-Kaneyama, Keiko Ishino, Nobuko Sakamoto, Tomoko Hishiki, Kaeko Yamaguchi, Kazunori Mori, Jun-ichi Mashimo, and Kiyoshi Nose. "Hic-5 Communicates between Focal Adhesions and the Nucleus through Oxidant-Sensitive Nuclear Export Signal." Molecular Biology of the Cell 14, no. 3 (March 2003): 1158–71. http://dx.doi.org/10.1091/mbc.02-06-0099.
Full textAbstract:
hic-5 was originally isolated as an H2O2-inducible cDNA clone whose product was normally found at focal adhesions. In this study, we found that Hic-5 accumulated in the nucleus in response to oxidants such as H2O2. Other focal adhesion proteins including paxillin, the most homologous to Hic-5, remained in the cytoplasm. Mutation analyses revealed that the C- and N-terminal halves of Hic-5 contributed to its nuclear localization in a positive and negative manner, respectively. After the finding that leptomycin B (LMB), an inhibitor of nuclear export signal (NES), caused Hic-5 to be retained in the nucleus, Hic-5 was demonstrated to harbor NES in the N-terminal, which was sensitive to oxidants, thereby regulating the nuclear accumulation of Hic-5. NES consisted of a leucine-rich stretch and two cysteines with a limited similarity to Yap/Pap-type NES. In the nucleus, Hic-5 was suggested to participate in the gene expression of c-fos. Using dominant negative mutants, we found that Hic-5 was actually involved in endogenous c-fos gene expression upon H2O2 treatment. Hic-5 was thus proposed as a focal adhesion protein with the novel aspect of shuttling between focal adhesions and the nucleus through an oxidant-sensitive NES, mediating the redox signaling directly to the nucleus.
29
Chodankar, Rajas, Dai-Ying Wu, Daniel S. Gerke, and Michael R. Stallcup. "Selective Coregulator Function and Restriction of Steroid Receptor Chromatin Occupancy by Hic-5." Molecular Endocrinology 29, no. 5 (May 1, 2015): 716–29. http://dx.doi.org/10.1210/me.2014-1403.
Full textAbstract:
Abstract Steroid receptors (SRs) bind specific DNA regulatory sequences, thereby activating and repressing gene expression. We previously showed that transcriptional coregulator Hic-5 facilitates glucocorticoid regulation of some genes but blocks glucocorticoid regulation of others. Here, in a genome-wide analysis, Hic-5 depletion dramatically increased the global number of sites occupied by glucocorticoid receptor (GR) α (the major GR isoform), and many binding sites blocked by Hic-5 were associated with genes for which Hic-5 also blocked glucocorticoid-regulated expression. Hic-5 had similar effects on GRγ (a splice variant of GRα) and estrogen receptor α (ERα), facilitating hormonal regulation of some genes and blocking hormonal regulation of others. As with GRα, Hic-5 blocking of hormonal gene regulation mediated by GRγ and ERα was associated with blocking of GRγ and ERα occupancy at nearby sites. Hic-5 supported hormonal regulation of many more genes for GRα than for GRγ or ERα and thus exhibited selective coregulator functions for different SRs. In contrast, the number of Hic-5–blocked genes was similar for all 3 SRs. In addition to classic coregulator activity, Hic-5 influences the genomic occupancy of multiple SRs and thereby blocks some aspects of hormonal regulation. Thus, Hic-5, because of its tissue-specific expression, could contribute to tissue-specific genomic occupancy and gene regulation by SRs.
30
Pignatelli, Jeanine, David A. Tumbarello, Ronald P. Schmidt, and Christopher E. Turner. "Hic-5 promotes invadopodia formation and invasion during TGF-β–induced epithelial–mesenchymal transition." Journal of Cell Biology 197, no. 3 (April 23, 2012): 421–37. http://dx.doi.org/10.1083/jcb.201108143.
Full textAbstract:
Transforming growth factor β (TGF-β)–stimulated epithelial–mesenchymal transition (EMT) is an important developmental process that has also been implicated in increased cell invasion and metastatic potential of cancer cells. Expression of the focal adhesion protein Hic-5 has been shown to be up-regulated in epithelial cells in response to TGF-β. Herein, we demonstrate that TGF-β–induced Hic-5 up-regulation or ectopic expression of Hic-5 in normal MCF10A cells promoted increased extracellular matrix degradation and invasion through the formation of invadopodia. Hic-5 was tyrosine phosphorylated in an Src-dependent manner after TGF-β stimulation, and inhibition of Src activity or overexpression of a Y38/60F nonphosphorylatable mutant of Hic-5 inhibited matrix degradation and invasion. RhoC, but not RhoA, was also required for TGF-β– and Hic-5–induced matrix degradation. Hic-5 also induced matrix degradation, cell migration, and invasion in the absence of TGF-β via Rac1 regulation of p38 MAPK. These data identify Hic-5 as a critical mediator of TGF-β–stimulated invadopodia formation, cell migration, and invasion.
31
Rich, Patricia, R. Brian Mitchell, Eric Schaefer, Paul R. Walker, John W. Dubay, Jason Boyd, David Oubre, et al. "Real-world performance of blood-based proteomic profiling in first-line immunotherapy treatment in advanced stage non-small cell lung cancer." Journal for ImmunoTherapy of Cancer 9, no. 10 (October 2021): e002989. http://dx.doi.org/10.1136/jitc-2021-002989.
Full textAbstract:
PurposeImmune checkpoint inhibition (ICI) therapy has improved patient outcomes in advanced non-small cell lung cancer (NSCLC), but better biomarkers are needed. A clinically validated, blood-based proteomic test, or host immune classifier (HIC), was assessed for its ability to predict ICI therapy outcomes in this real-world, prospectively designed, observational study.Materials and methodsThe prospectively designed, observational registry study INSIGHT (Clinical Effectiveness Assessment of VeriStrat® Testing and Validation of Immunotherapy Tests in NSCLC Subjects) (NCT03289780) includes 35 US sites having enrolled over 3570 NSCLC patients at any stage and line of therapy. After enrolment and prior to therapy initiation, all patients are tested and designated HIC-Hot (HIC-H) or HIC-Cold (HIC-C). A prespecified interim analysis was performed after 1-year follow-up with the first 2000 enrolled patients. We report the overall survival (OS) of patients with advanced stage (IIIB and IV) NSCLC treated in the first-line (ICI-containing therapies n=284; all first-line therapies n=877), by treatment type and in HIC-defined subgroups.ResultsOS for HIC-H patients was longer than OS for HIC-C patients across treatment regimens, including ICI. For patients treated with all ICI regimens, median OS was not reached (95% CI 15.4 to undefined months) for HIC-H (n=196) vs 5.0 months (95% CI 2.9 to 6.4) for HIC-C patients (n=88); HR=0.38 (95% CI 0.27 to 0.53), p<0.0001. For ICI monotherapy, OS was 16.8 vs 2.8 months (HR=0.36 (95% CI 0.22 to 0.58), p<0.0001) and for ICI with chemotherapy OS was unreached vs 6.4 months (HR=0.41 (95% CI 0.26 to 0.67), p=0.0003). HIC results were independent of programmed death ligand 1 (PD-L1). In a subgroup with PD-L1 ≥50% and performance status 0–1, HIC stratified survival significantly for ICI monotherapy but not ICI with chemotherapy.ConclusionBlood-based HIC proteomic testing provides clinically meaningful information for immunotherapy treatment decision in NSCLC independent of PD-L1. The data suggest that HIC-C patients should not be treated with ICI alone regardless of their PD-L1 expression.
32
Bai, Yiwen, Xubo Wu, Raymond CC Tsang, Ruisheng Yun, Yan Lu, Elizabeth Dean, and Alice YM Jones. "A Randomised Controlled Trial to Evaluate the Administration of the Health Improvement Card as a Health Promotion Tool: A Physiotherapist-Led Community-Based Initiative." International Journal of Environmental Research and Public Health 17, no. 21 (November 2, 2020): 8065. http://dx.doi.org/10.3390/ijerph17218065.
Full textAbstract:
A randomised controlled trial was conducted to evaluate the administration of the Health Improvement Card (HIC) on lifestyle practices and biometric variables in community-dwelling Chinese participants. Adults living in Shanghai were randomly assigned to either the HIC-intervention or control group. Measurements/assessments were conducted at baseline and three-month follow-up. Supervised physiotherapy students administered the HIC and four standardised questionnaires related to health and wellbeing. Both groups received a health promotion education pamphlet. Based on participants’ HIC biometric and lifestyle scores, students prescribed lifestyle, and exercise advice to the HIC-intervention group. 171 individuals (39 men, 132 women) (mean age 68.4 ± 9.7 y) participated. At follow-up, body mass index (BMI) and waist circumference decreased significantly in the HIC-intervention group. Furthermore, the number of participants in the HIC-intervention group categorised as low risk regarding their physical activity and dietary practices, increased by 32.2% and 20%, respectively. Changes in standardised questionnaire scores did not meet minimum clinically importance differences in either group. This is the first study to demonstrate that HIC-informed health promotion education can improve people’s lifestyle practices, thereby, objective biometric variables. Evaluation of the effect of HIC-informed lifestyle education on some biometric parameters (blood pressure and BMI) may warrant a longer timeframe.
33
Lodes, Birgit, and Matthias Miller. ""Hic jacet Ludevicus Fenfflius"." Die Musikforschung 58, no. 3 (September 22, 2021): 260–66. http://dx.doi.org/10.52412/mf.2005.h3.628.
Full textAbstract:
Aufgrund neu entdeckter Quellen lassen sich einige Lebensdaten Ludwig Senfls näher bestimmen: Senfl wurde zwischen 1489 und 1491 geboren; er muss vor dem 10. August 1543 gestorben sein; und er hatte vermutlich eine zweite Ehefrau: Maria Halbhirn.
bms online (Schöner, Oliver)
34
Baldran, Jacqueline. "Barbarus hic ego sum." Sigila N�33, no. 1 (2014): 99. http://dx.doi.org/10.3917/sigila.033.0099.
Full text
35
OSADA, Makoto, Tsukasa OHMORI, Yutaka YATOMI, Kaneo SATOH, Shigemi HOSOGAYA, and Yukio OZAKI. "Involvement of Hic-5 in platelet activation: integrin αIIbβ3-dependent tyrosine phosphorylation and association with proline-rich tyrosine kinase 2." Biochemical Journal 355, no. 3 (April 24, 2001): 691–97. http://dx.doi.org/10.1042/bj3550691.
Full textAbstract:
Hic-5 and paxillin, members of the LIM protein family, have been shown to be localized in focal adhesion and to have a role in integrin-mediated signalling. In the present study we examined the involvement of Hic-5 in human platelet activation: platelets express Hic-5 but not paxillin, whereas human umbilical-vein vascular endothelial cells and MEG-01 cells express mainly paxillin. When platelets were stimulated with thrombin, collagen or the stable thromboxane A2 analogue U46619, Hic-5 was markedly tyrosine-phosphorylated, in a manner dependent on integrin αIIbβ3-mediated aggregation. In addition, direct activation of protein kinase C with PMA resulted in tyrosine phosphorylation of Hic-5 only when platelets were fully aggregated with the exogenous addition of fibrinogen. Furthermore, PMA-induced Hic-5 tyrosine phosphorylation was also observed when platelets adhered to immobilized fibrinogen. In studies on immunoprecipitation and immunodepletion, Hic-5 seemed to associate with proline-rich tyrosine kinase 2 (Pyk2) but only marginally with focal adhesion kinase. When platelets were stimulated with thrombin, both Hic-5 and Pyk2 translocated to the cytoskeleton from the cytosol and membrane fractions in a manner dependent on αIIbβ3-mediated aggregation. Finally, on stimulation with PMA, Hic-5, as well as Pyk2, translocated to the cell periphery, where a meshwork of actin filaments assembled after adhesion to immobilized fibrinogen. Our results suggest that Hic-5 might be important in platelet aggregation and adhesion, in a manner dependent on αIIbβ3-mediated outside-in signalling, through association with Pyk2.
36
Agapejev, Svetlana, Ana Flávia P. Pouza, Rodrigo Bazan, and Antonio Tadeu S. Faleiros. "Aspectos clínicos e evolutivos da hidrocefalia na neurocisticercose." Arquivos de Neuro-Psiquiatria 65, no. 3a (September 2007): 674–80. http://dx.doi.org/10.1590/s0004-282x2007000400025.
Full textAbstract:
Com o propósito de analisar os aspectos clínicos da hidrocefalia (HDC) na neurocisticercose (NCC), realizou-se o estudo retrospectivo de 47 prontuários de pacientes com HDC e NCC. Verificou-se que 70,2% eram homens, entre 21 e 50 anos. A hipertensão intracraniana (HIC) ocorreu em todos os pacientes, cefaléia (CEF) em 89,4%, meningoencefalite (ME) em 80,8% e distúrbios psíquicos (PSI) em 74,5%. A síndrome liquórica da NCC foi detectada em 65,9% pacientes. Além da HDC, as tomografias computadorizadas de crânio (TC) mostraram lesões císticas e edema cerebral difuso em 59,6% cada, calcificações em 55,3%. Dos 41 pacientes (87,2%) com derivação ventriculoperitoneal (DVP), em 22 (53,7%) deles foram necessárias uma a sete revisões/paciente (média=3). A evolução foi satisfatória em 51,1% e fatal em 31,9%. Conclui-se que a hidrocefalia é mais comum no sexo masculino em idade produtiva, tendo a HIC, CEF, MN e PSI como manifestações freqüentes e que, a necessidade de revisões de DVP, piora o prognóstico.
37
Park, Jin Sung, Jin Woo Lee, Joong Ki Hwang, and Sung Jin Kim. "Effects of Alloying Elements (C, Mo) on Hydrogen Assisted Cracking Behaviors of A516-65 Steels in Sour Environments." Materials 13, no. 18 (September 21, 2020): 4188. http://dx.doi.org/10.3390/ma13184188.
Full textAbstract:
This study examined the effects of alloying elements (C, Mo) on hydrogen-induced cracking (HIC) and sulfide stress cracking (SSC) behaviors of A516-65 grade pressure vessel steel in sour environments. A range of experimental and analytical methods of HIC, SSC, electrochemical permeation, and immersion experiments were used. The steel with a higher C content had a larger fraction of banded pearlite, which acted as a reversible trap for hydrogen, and slower diffusion kinetics of hydrogen was obtained. In addition, a higher hardness in the mid-thickness regions of the steel, due to center segregation, resulted in easier HIC propagation. On the other hand, the steel with a higher Mo content showed more dispersed banded pearlite and a larger amount of irreversibly trapped hydrogen. Nevertheless, the addition of Mo to the steel can deteriorate the surface properties through localized pitting and the local detachment of corrosion products with uneven interfaces, increasing the vulnerability to SSC. The mechanistic reasons for the results are discussed, and a desirable alloy design for ensuring an enhanced resistance to hydrogen assisted cracking (HAC) is proposed.
38
Demunter, H., H. Jossa, K. Vandenhout, S. Claes, and R. Bruffaerts. "Scientific evaluation of the High and Intensive Care (HIC) pilot projects in Belgian mental healthcare." European Psychiatry 65, S1 (June 2022): S621. http://dx.doi.org/10.1192/j.eurpsy.2022.1590.
Full textAbstract:
Introduction The systematic monitoring and evaluation of innovative healthcare programs are essential to develop long-term sustainable solutions that respond to the health needs in the population (Porter & Teisberg, 2006). One such innovative healthcare program is the psychiatric High and Intensive Care (HIC) model, gradually implemented in 9 Belgian psychiatric hospitals since 2019. The HIC-model focuses on intensive patient-oriented care, in an attempt to exclude coercive measures and promote collaborative efforts between staff, patients, and relatives (Voskes et al., 2021). Objectives We discuss the following research questions: (1) which clinical profiles of patients are treated in HIC units in Belgium?; (2) Is the implementation of HIC units associated with decrease of coercive measures?; (3) What are self-reported aspects of HIC treatment approaches as experienced by patients, family and/or close friends, and professional staff (both working on the HIC units as well as in external healthcare facilities), and (4) what is the role of HIC units in the organization of mental healthcare on the societal level (e.g. The function of HIC in regional psychiatric networks or the health economic aspects)? Methods In order to develop a sustainable policy on HIC in Belgium, we use a scientist-practitioner perspective including a multimethod approach. Results The preliminary results of the first six months of data collection will be presented. Conclusions The preliminary conclusions of the first six months of data collection will be presented. Disclosure No significant relationships.
39
Kusano, Shuichi, and Nancy Raab-Traub. "I-mfa Domain Proteins Interact with Axin and Affect Its Regulation of the Wnt and c-Jun N-Terminal Kinase Signaling Pathways." Molecular and Cellular Biology 22, no. 18 (September 15, 2002): 6393–405. http://dx.doi.org/10.1128/mcb.22.18.6393-6405.2002.
Full textAbstract:
ABSTRACT I-mfa has been identified as an inhibitor of myogenic basic helix-loop-helix transcription factors, and a related human I-mfa domain-containing protein (HIC) also has been identified as a protein that regulates Tat- and Tax-mediated expression of viral promoters. HIC and I-mfa represent a family of proteins that share a highly conserved cysteine-rich domain, termed the I-mfa domain. We show here that both I-mfa domain proteins, HIC and I-mfa, interacted in vivo with the Axin complex through their C-terminal I-mfa domains. This interaction inhibited Axin-mediated downregulation of free levels of cytosolic β-catenin. I-mfa and HIC also both directly interacted with lymphocyte enhancer factor (LEF); however, I-mfa but not HIC significantly inhibited reporter constructs regulated by β-catenin. The overexpression of HIC but not I-mfa decreased the inhibitory effects of Axin on β-catenin-regulated reporter constructs, while both HIC and I-mfa decreased Axin-mediated c-Jun N-terminal kinase (JNK) activation. These data reveal for the first time that I-mfa domain proteins interact with the Axin complex and affect Axin regulation of both the Wnt and the JNK activation pathways. Interestingly, HIC differs from I-mfa in that I-mfa affects both Axin function and T-cell factor- or LEF-regulated transcription in the Wnt signaling pathway while HIC affects primarily Axin function.
40
Shibanuma, M., E. Mochizuki, R. Maniwa, J. Mashimo, N. Nishiya, S. Imai, T. Takano, M. Oshimura, and K. Nose. "Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts." Molecular and Cellular Biology 17, no. 3 (March 1997): 1224–35. http://dx.doi.org/10.1128/mcb.17.3.1224.
Full textAbstract:
The hic-5 gene encodes a novel protein with Zn finger-like (LIM) motifs, the expression of which increases during cellular senescence. The ectopic expression of hic-5 in nontumorigenic immortalized human fibroblasts, whose expression levels of hic-5 were significantly reduced in comparison with those of mortal cells, decreased colony-forming efficiency. Stable clones expressing high levels of hic-5 mRNA showed higher levels of mRNAs for several extracellular matrix-related proteins, along with the alteration of an alternative splicing as seen in senescent cells and decreased c-fos inducibility. Furthermore, these clones acquired a senescence-like phenotype, such as growth retardation; senescence-like morphology; and increased expression of Cip1/WAF1/sdi1 after 20 to 40 population doublings. On the other hand, antisense RNA expression of hic-5 in human normal diploid fibroblasts delayed the senescence process. HIC-5 was localized in nuclei and had affinity for DNA. Based on these observations, we speculated that HIC-5 affected the expression of senescence-related genes through interacting with DNA and thereby induced the senescence-like phenotypes. To our knowledge, hic-5 is the first single gene that could induce senescence-like phenotypes in a certain type of immortalized human cell and mediate the normal process of senescence.
41
Li, Ji Hui, Li Qiang Ma, Yan Zhao Li, Wen Jing Li, and Jian Wei Yue. "The Flotation Process with High Intensity Conditioning and Cleaning for Fine Coal." Advanced Materials Research 1010-1012 (August 2014): 1636–39. http://dx.doi.org/10.4028/www.scientific.net/amr.1010-1012.1636.
Full textAbstract:
The properties analyzing of flotation feed sample told that this fine coal sample is high-ash and hard-to-float coal slime. The ash reduction comparison of the step-by-step release flotation test with high intensity conditioning (HIC) or not, and the comparison of flotation test with HIC and adding depressant were made. The results showed that HIC can significantly improve the flotation effect for high-ash and hard-to-float coal slime. Comparing with the traditional step-by-step flotation process, if it meets the demand of ash content is 10.00% and 8.00%, the clean coal yield with HIC will increase 18 and 29 percentage points respectively; comparing with the effect of floatation adding depressant, HIC has more help to reduce the ash content and increase the yield of clean coal. In addition, HIC will save a lot of flotation reagents.
42
Sahasrabudhe, Kieran, Melanie Rebechi, Ying Huang, Gregory Behbehani, Bhavana Bhatnagar, James Stewart Blachly, Bradley Wayne Blaser, et al. "Effect of induction intensity on survival in patients with acute myeloid leukemia." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e19004-e19004. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e19004.
Full textAbstract:
e19004 Background: Acute Myeloid Leukemia (AML) has traditionally been treated frontline with intensive induction chemotherapy in patients fit enough for this treatment. The FDA has approved several oral targeted therapies for AML in recent years. The survival impact of these agents vs induction chemotherapy is unknown. Methods: In this single-center, retrospective study, patients diagnosed with AML from 2015-2020 were included if they received treatment with either high intensity chemotherapy (HiC) or lower intensity targeted therapy (LITT). HiC was defined as a regimen containing cytarabine + anthracycline given on a “7+3” based schedule. Patients treated with liposomal cytarabine-daunorubicin were excluded. LITT was defined as venetoclax, gilteritinib, enasidenib, or ivosidenib alone or in combination with a hypomethylating agent. Patients fell into four groups: HiC only, LITT only, HiC followed by LITT, and LITT followed by HiC with assignment censored at transplant. Overall survival (OS) was estimated using Kaplan-Meier method and patients receiving any HiC vs LITT only were compared using log-rank test. Results: A total of 332 patients were included: 177 received HiC only, 116 LITT only, 32 HiC before LITT, and 7 LITT before HiC. Baseline characteristics and OS data are outlined in the table. The any HiC group had a lower median age and more patients with WBC >10 K/µL at diagnosis, as well as more patients receiving allogeneic hematopoietic cell transplant (HCT). OS was superior in the any HiC group vs LITT only group. Receipt of any HiC remained predictive of OS after adjusting for age (HR 0.65, 95% CI 0.44-0.96, p = 0.03); however, was no longer predictive of OS after adjusting for age and receipt of HCT. Conclusions: While HiC was associated with superior OS compared to LITT only treatment in univariable analysis, the survival benefit was no longer apparent after adjusting for age and receipt of HCT. The results suggest that intensity of AML treatment is less impactful on prognosis than ability to receive HCT. Differences in age were likely confounded by clinical trial eligibility and prescribing information specifically affecting patients receiving LITT. In the era of LITT, prospective randomized studies of intensity of AML therapy, particularly in non-favorable risk disease, are imperative to striking a balance between toxicity and cure for patients of all ages.[Table: see text]
43
Pootrakul, Pensri, Wanida Chua-anusorn, Adam Fleming, Paul Clark, Pornpan Sirankapracha, Udom Kachintorn, Somsak Chanyawattiwongse, Pichest Metarugcheep, and Tim St. Pierre. "Non-Invasive Monitoring of Hepatic Iron Concentration during Oral Chelation in Patients with Non-Regularly Transfused β-Thalassemia/Hb E Disease." Blood 104, no. 11 (November 16, 2004): 3615. http://dx.doi.org/10.1182/blood.v104.11.3615.3615.
Full textAbstract:
Abstract Current non-invasive measurement techniques of hepatic iron concentration (HIC) include magnetic susceptometry (SQUID) and the magnetic resonance imaging (MRI) methods utilising T2 and T2*. HIC can be quantified through image measurement of the proton transverse relaxation rate (R2) (St. Pierre et al Blood 2004). The potential for using the St Pierre method to monitor changes in HIC of patients with β-thalassemia/Hb E undergoing iron chelation therapy was investigated. Seventeen non-tansfusion dependant β-thal/Hb E patients who had not previously undergone chelation were studied. Subjects were chelated with the oral iron chelator Deferiprone (DFP) and had their HIC measured using both the R2-MRI and biopsy non-heme iron techniques pre and post treatment. Ferritin levels were also assayed for comparison. The subjects ages ranged from of 13 to 53 years (mean 31.6, SD 11.5). DFP was administered at a low dose of 50 mg/kg/Day with divided doses 2 –3 times daily. The periods of drug exposure ranged between 53 and 77 weeks (mean 64.1, SD 8.4). HIC by R2-MRI and tissue iron chemical analysis, and serum ferritin Measurement R2-HIC (mg/g DW) Biopsy-HIC (mg/g DW) Serum Ferritin (ng/ml) Mean ± SD Range Mean ± SD Range G.Mean ± SE Range Initial 17.8 ± 6.6 5.7 – 29.7 18.3 ± 9.0 6.0 – 40.1 2526 ± 432 842 – 6072 Final 8.4 ± 7.9 1.0 – 23.9 7.4 ± 7.3 0.2 – 25.5 416 ± 236 113 – 4030 The results show a significant decrease of HIC after long term administration of DFP with MRI and biopsy (p= .0004 and p<0.0001 respectively). Spearman rank correlations of R2-HIC with the liver non-heme Fe and serum ferritin measures gave positive values of 0.866 (p < 0.0001) and 0.768 (p < 0.0001) respectively. The mean reduction of R2-HIC, biopsy-HIC and serum ferritin were 53%, 69%, and 74%, respectively. A decrease of 20.5% (SD ±14.9%) in the standard deviation of the R2 distribution was observed suggesting a decrease in iron heterogeneity accompanied the mean HIC decrease. The results suggest that R2 MRI has the potential to be used as a clinical monitoring tool in chelation therapy.
44
Suhir, E. "On a Paradoxical Phenomenon Related to Beams on Elastic Foundation: Could External Compliant Leads Reduce the Strength of a Surface-Mounted Device?" Journal of Applied Mechanics 55, no. 4 (December 1, 1988): 818–21. http://dx.doi.org/10.1115/1.3173727.
Full textAbstract:
Compliant external electrical leads are often utilized as strain buffers in surface-mounted device technology to provide the necessary stress relief for the device, when the substrate is subjected to bending. A paradoxical situation was observed, however, during testing of compliant leaded hybrid integrated circuits (HIC): In some tests the bending moment, applied to the printed wire board (PWB) and causing HIC fracture, turned out smaller (not greater), when leads of greater compliance were installed. We show that such a paradoxical situation is due to the redistribution of lead reactions at certain combinations of HIC length, HIC and PWB flexural rigidity, and spring constant of the elastic attachment. Our analysis has indicated, that only sufficiently compliant leads can essentially reduce the stresses, while leads of moderate compliance can result in even greater stresses in the HIC than stiff leads. We suggest an easy-to-calculate governing parameter, which characterizes the mechanical behavior of HIC/PWB and similar assemblies with compliant attachments.
45
Mitchell, R. Brian, Patricia Rich, Paul R. Walker, Eric S. Schaefer, Jiahuai Tan, Nagaprasad Nagajothi, John W. Dubay, et al. "Real-world performance of blood-based host immune profiling in first-line immunotherapy treatment in advanced-stage non-small cell lung cancer." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 9545. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.9545.
Full textAbstract:
9545 Background: Immune checkpoint inhibition (ICI) has improved outcomes for many treatment-naïve advanced non-small cell lung cancer (NSCLC) patients. However, better biomarkers are needed to predict patient response and guide treatment decisions considering added toxicity and higher cost of combination treatments. A prospectively designed, observational study assessed the ability of a clinically validated, blood-based, host immune classifier (HIC) to predict ICI therapy outcomes. Methods: The study (NCT03289780) includes 33 US sites having enrolled over 3,000 NSCLC patients at any stage and line of therapy. All enrolled patients are tested and designated HIC-Hot (HIC-H) or HIC-Cold (HIC-C) prior to therapy initiation. An interim analysis of secondary and exploratory endpoints was performed after 12- 18 months (mo) follow-up with the first 2,000 enrolled patients. We report the overall survival (OS) of HIC-defined subgroups comprising advanced stage (IIIB and higher) NSCLC patients treated with first-line regimens (284 ICI containing treatments, 877 total first-line patients). Results: In a real-world clinical setting, OS of advanced stage NSCLC treatment-naïve patients receiving platinum-based chemotherapy (n = 392) did not differ significantly from patients receiving any type of ICI containing regimen (n = 284); 11.7 mo vs. 14.4 mo; hazard ratio (HR) = 0.94 [95% confidence interval (CI): 0.76–1.17], p = 0.59. HIC-H patients experienced longer survival than HIC-C across multiple regimens, including ICI. For all ICI, median OS (mOS) was not reached for HIC-H (n = 196, CI: 15.4 mo–undefined) vs. 5.0 mo (n = 88, CI: 2.9 mo–6.4 mo) for HIC-C patients (HR = 0.38 [CI: 0.27–0.53], p < 0.0001). Similar results were seen in the ICI only (16.8 mo vs. 2.8 mo; n = 117, HR = 0.36 [CI: 0.22–0.58], p < 0.0001) and ICI/chemotherapy combination subgroups (unreached vs. 6.4 mo; n = 161, HR = 0.41 [CI: 0.26–0.67], p = 0.0003). In the PD-L1 high cohort (PD-L1 ≥50%), mOS for HIC-H was not reached (n = 81, CI: 13.9 mo–undefined) vs. 3.9 mo (n = 41, CI: 2.1 mo–7.8 mo) for HIC-C (HR: 0.39 [CI: 0.24-0.66], p = 0.0003). HIC results were independent of PD-L1 score (p = 0.81) and remained predictive of OS in first-line ICI-treated patients when adjusted for PD-L1 and other covariates by multivariate analysis (HR = 0.40 [CI: 0.28-0.58], p < 0.0001). Conclusions: Blood-based host immune profiling may provide clinically meaningful information for selecting NSCLC patients for two common ICI containing regimens independent of and complementary to PD-L1 score.
46
Fujishiro, Taishi, Takuya Hara, Kyono Yasuda, Daisuke Mizuno, Nobuyuki Ishikawa, Eiji Tada, and Mitsuo Kimura. "Sour Environmental Severity for Hydrogen-Induced Cracking Susceptibility." Corrosion 78, no. 2 (January 2, 2022): 189–97. http://dx.doi.org/10.5006/3901.
Full textAbstract:
The severity of sour environments has been determined in accordance with the European Federation of Corrosion 16 and NACE MR0175/ISO 15156-2:2015 standards for carbon and low-alloy steels, based on the experimental results of sulfide stress cracking (SSC). However, the severity map obtained from SSC test results cannot be applicable to the hydrogen-induced cracking (HIC) susceptibility. In this study, the hydrogen permeability and crack area ratio of HIC under various pH and H2S partial pressures (pH2S) were measured to establish the link between the sour environmental severity and HIC susceptibility using grades X65 to X80 steels for linepipes. In addition, the hydrogen concentration at the location of the HIC was calculated by the finite element analysis. The results showed that the sour environmental severity map obtained from hydrogen permeation tests changes with time because the hydrogen permeability reached maximum values in the early stage and steady-state values in the later stage. Then, the HIC susceptibility did not correspond to the maximum permeability, but to the steady-state hydrogen permeability. In addition, the hydrogen content at the location of the HIC did not correspond to the maximum hydrogen permeability but corresponded to the steady-state hydrogen permeability, because HIC occurred in the center segregation part and the hydrogen atoms required a certain time to diffuse from the metal surface to the mid-thickness. These results suggest that the HIC susceptibility is dominated by the severity map obtained from the steady-state hydrogen permeability.
47
Maier, Lisa, Ricarda von Krüchten, Roberto Lorbeer, Jule Filler, Johanna Nattenmüller, Barbara Thorand, Wolfgang Koenig, et al. "Distribution and Associated Factors of Hepatic Iron—A Population-Based Imaging Study." Metabolites 11, no. 12 (December 15, 2021): 871. http://dx.doi.org/10.3390/metabo11120871.
Full textAbstract:
Hepatic iron overload can cause severe organ damage; therefore, an early diagnosis and the identification of potential risk factors is crucial. We aimed to investigate the sex-specific distribution of hepatic iron content (HIC) in a population-based cohort and identify relevant associated factors from a panel of markers. We analyzed N = 353 participants from a cross-sectional sample (KORA FF4) who underwent whole-body magnetic resonance imaging. HIC was assessed by single-voxel spectroscopy with a high-speed T2-corrected multi-echo technique. A large panel of markers, including anthropometric, genetic, and laboratory values, as well as behavioral risk factors were assessed. Relevant factors associated with HIC were identified by variable selection based on LASSO regression with bootstrap resampling. HIC in the study sample (mean age at examination: 56.0 years, 58.4% men) was significantly lower in women (mean ± SD: 39.2 ± 4.1 s−1) than in men (41.8 ± 4.7 s−1, p < 0.001). Relevant factors associated with HIC were HbA1c as well as prediabetes for men and visceral adipose tissue as well as age for women. Hepatic fat, alcohol consumption, and genetic risk score for iron levels were associated with HIC in both sexes. In conclusion, there are sex-specific associations of HIC with markers of body composition, glucose metabolism, and alcohol consumption.
48
Mahdi, Hashim A., Mohammed Alluhidan, Abdulrahman B. Almohammed, Mohammad Alfelali, Ramon Z. Shaban, Robert Booy, and Harunor Rashid. "Epidemiological Differences in Hajj-Acquired Airborne Infections in Pilgrims Arriving from Low and Middle-Income versus High-Income Countries: A Systematised Review." Tropical Medicine and Infectious Disease 8, no. 8 (August 17, 2023): 418. http://dx.doi.org/10.3390/tropicalmed8080418.
Full textAbstract:
This systematised review aims to compare the epidemiological patterns of Hajj-acquired airborne infections among pilgrims from low and middle-income countries (LMIC) versus those from high-income countries (HIC). A PubMed search was carried out for all published articles before February 2023, using a combination of MeSH terms and text words. The Newcastle–Ottawa Scale (NOS) was used to assess data quality. From a total of 453 titles identified, 58 studies were included in the review (LMIC = 32, and HIC = 26). In the pooled sample, there were 27,799 pilgrims aged 2 days to 105 years (male: female = 1.3:1) from LMIC and 70,865 pilgrims aged 2 months to 95 years (male: female = 1:1) from HIC. Pilgrims from both HIC and LMIC had viral and bacterial infections, but pilgrims from HIC tended to have higher attack rates of viral infections than their LMIC counterparts. However, the attack rates of bacterial infections were variable: for instance, pilgrims from LMIC seemed to have higher rates of meningococcal infections (0.015–82% in LMIC vs. 0.002–40% in HIC) based on the study population, but not Mycobacterium tuberculosis (0.7–20.3% in LMIC vs. 38% in HIC). Targeted measures are needed to prevent the spread of airborne infections at Hajj.
49
Petropoulos, Christos, Christiane Oddou, Anouk Emadali, Edwige Hiriart-Bryant, Cyril Boyault, Eva Faurobert, Scott Vande Pol, et al. "Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes." Journal of Cell Biology 213, no. 5 (June 6, 2016): 585–99. http://dx.doi.org/10.1083/jcb.201510036.
Full textAbstract:
Invadosomes are acto-adhesive structures able to both bind the extracellular matrix (ECM) and digest it. Paxillin family members—paxillin, Hic-5, and leupaxin—are implicated in mechanosensing and turnover of adhesion sites, but the contribution of each paxillin family protein to invadosome activities is unclear. We use genetic approaches to show that paxillin and Hic-5 have both redundant and distinctive functions in invadosome formation. The essential function of paxillin-like activity is based on the coordinated activity of LD motifs and LIM domains, which support invadosome assembly and morphology, respectively. However, paxillin preferentially regulates invadosome assembly, whereas Hic-5 regulates the coupling between ECM degradation and acto-adhesive functions. Mass spectrometry analysis revealed new partners that are important for paxillin and Hic-5 specificities: paxillin regulates the acto-adhesive machinery through janus kinase 1 (JAK1), whereas Hic-5 controls ECM degradation via IQGAP1. Integrating the redundancy and specificities of paxillin and Hic-5 in a functional complex provides insights into the coupling between the acto-adhesive and ECM-degradative machineries in invadosomes.
50
Wood, John C., Cathleen Enriquez, Nilesh Ghugre, J. Michael Tyzka, Susan Carson, Marvin D. Nelson, and Thomas D. Coates. "MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients." Blood 106, no. 4 (August 15, 2005): 1460–65. http://dx.doi.org/10.1182/blood-2004-10-3982.
Full textAbstract:
Abstract Measurements of hepatic iron concentration (HIC) are important predictors of transfusional iron burden and long-term outcome in patients with transfusion-dependent anemias. The goal of this work was to develop a readily available, noninvasive method for clinical HIC measurement. The relaxation rates R2 (1/T2) and R2* (1/T2*) measured by magnetic resonance imaging (MRI) have different advantages for HIC estimation. This article compares noninvasive iron estimates using both optimized R2 and R2* methods in 102 patients with iron overload and 13 controls. In the iron-overloaded group, 22 patients had concurrent liver biopsy. R2 and R2* correlated closely with HIC (r2 ≥ .95) for HICs between 1.33 and 32.9 mg/g, but R2 had a curvilinear relationship to HIC. Of importance, the R2 calibration curve was similar to the curve generated by other researchers, despite significant differences in technique and instrumentation. Combined R2 and R2* measurements did not yield more accurate results than either alone. Both R2 and R2* can accurately measure hepatic iron concentration throughout the clinically relevant range of HIC with appropriate MRI acquisition techniques. (Blood. 2005;106:1460-1465)