Relevant bibliographies by topics / HIFU

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  2. Dissertations / Theses
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  5. Conference papers
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Academic literature on the topic 'HIFU'

Author: Grafiati
Published: 4 June 2021
Last updated: 12 April 2025

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Journal articles on the topic "HIFU"

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Shin, Eui-Ji, Byungwoo Kang, and Jin Chang. "Real-Time HIFU Treatment Monitoring Using Pulse Inversion Ultrasonic Imaging." Applied Sciences 8, no. 11 (November 11, 2018): 2219. http://dx.doi.org/10.3390/app8112219.

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Real-time monitoring of high-intensity focused ultrasound (HIFU) surgery is essential for safe and accurate treatment. However, ultrasound imaging is difficult to use for treatment monitoring during HIFU surgery because of the high intensity of the HIFU echoes that are received by an imaging transducer. Here, we propose a real-time HIFU treatment monitoring method based on pulse inversion of imaging ultrasound; an imaging transducer fires ultrasound twice in 0° and 180° phases for one scanline while HIFUs of the same phase are transmitted in synchronization with the ultrasound transmission for imaging. By doing so, HIFU interferences can be eliminated after subtracting the two sets of the signals received by the imaging transducer. This function was implemented in a commercial research ultrasound scanner, and its performance was evaluated using the excised bovine liver. The experimental results demonstrated that the proposed method allowed ultrasound images to clearly show the echogenicity change induced by HIFU in the excised bovine liver. Additionally, it was confirmed that the moving velocity of the organs in the abdomen due to respiration does not affect the performance of the proposed method. Based on the experimental results, we believe that the proposed method can be used for real-time HIFU surgery monitoring that is a pivotal function for maximized treatment efficacy.
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Bespalov, Vladimir, Grigoriy Tochilnikov, Konstantin Senchik, Yelena Yermakova, Yelizaveta Kovalevskaya, Georgiy Gafton, and A. Berkovich. "HIGH-INTENSITY FOCUSED ULTRASOUND IN THE TREATMENT OF MALIGNANT AND BENIGN TUMORS." Problems in oncology 66, no. 1 (January 1, 2020): 29–35. http://dx.doi.org/10.37469/0507-3758-2020-66-1-29-35.

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The review article discusses the possibilities of using high-intensity focused ultrasound (HIFU) in oncology. The technical principles and features of HIFU ablation, a brief history of the development of HIFU therapy, the principles of HIFU therapy, the physical basis of the HIFU ablation method, and the mechanisms of antitumor action of HIFU therapy are presented. The results and benefits of HIFU therapy for various malignant and benign tumors are discussed.
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Pasticier, Gilles, Ji-Wann Lee, Sebastien Crouzet, J. Soria, Christelle Medollima, Florence Mege-Lechevallier, Jean-Yves Chapelon, Olivier Rouviere, and Albert Gelet. "Localized prostate cancer and salvage treatment: EBRT first + salvage HIFU or HIFU first + salvage EBRT? A single-institution matched pair analysis over a 20-year period." Journal of Clinical Oncology 35, no. 6_suppl (February 20, 2017): 77. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.77.

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77 Background: In the field of curative treatment for localized prostate cancer, HIFU (High Intensity Focused ultrasound) is one of salvage option after EBRT(external beam radiation therapy) failure and EBRT is the standard salvage option for local relapse after HIFU.Our aim was to compare and evaluate the oncologic outcomes between HIFU first + salvage EBRT versus EBRT first +salvage HIFU. Methods: Using a matched pair analysis, 342 Patients (171 in each group) treated between 1994 and 2014 in the same institution were prospectively followed and matched to a 1:1 basis. Outcome measurements: Overall Survival Rate(OSR), cancer specific(CSSR) and metastasis free (MFSR) survival rates were the primary endpoints. Secondary endpoints were survival rate free of hormone therapy (HTFR) and the rate of side effects Clavien score ≥ 3. Results: Mean follow-up were 114 and 124 months for HIFU+ S-EBRT and EBRT + S-HIFU respectively. At 7 years from the primary treatment , the MFSR were significantly better after HIFU first +S- EBRT than after EBRT first+S- HIFU: 96% vs 91%% (p:0.011). The OSR and the CSSR were not significantly different in the two arms (97% and 99% after HIFU+S- EBRT versus 96% and 98% after EBRT+S- HIFU). The HTFR at 7 years was significantly different (p <0.001) after HIFU+ S-EBRT than after EBRT+ S-HIFU 90% versus 69%. In multivariable Cox regression, the initial Gleason sum ≥ 8 and the treatment strategy were predictors of MFSR (risk ratio 3.2 for treatment modality). The rate of side effect Clavien score≥ 3 was significantly higher (p:0.01) in the EBRT+ S-HIFU arm than in the HIFU+ S-EBRT arm. The rate of urinary toxicity (severe incontinence and bladder outlet obstruction) were worse in the EBRT+ S-HIFU arm than in HIFU+S-EBRT arm: 9.4% and 15.2% vs 1.2% and 7.6% (p:0.01 and 0.078). Conclusions: In this single-institution Matched Pair comparison, the MFSR and HTFR were significantly better in the HIFU+S-EBRT arm than in the EBRT+S-HIFU arm. The rate of urinairy toxicity and Clavien≥3 side-effects were Higher in the EBRT + S-HIFU arm than in the HIFU + S-EBRT arm.
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Wang, James, Chin-Hsin Huang, Oscar Echeagaray, Siamak Amirfakhri, Sarah Blair, William Trogler, Andrew Kummel, and Clark Chen. "SURG-33. IMMUNO-STIMULATION THROUGH SURGICALLY ADMINISTERED MECHANICAL HIGH INTENSITY FOCUSED ULTRASOUND." Neuro-Oncology 21, Supplement_6 (November 2019): vi246. http://dx.doi.org/10.1093/neuonc/noz175.1033.

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Abstract INTRODUCTION While immunotherapy through anti-PD1 checkpoint inhibition has demonstrated impressive clinical efficacy against a number of tumor types, its application has been ineffective against glioblastomas. METHODS We wished to determine whether high intensity focused ultrasound (HIFU) augment the efficacy of anti-PD1 checkpoint inhibition against glioblastomas. HIFU can be surgically administered through low-duty cycle to induce subcellular fragmentation without causing temperature elevation (termed mechanical HIFU). Alternatively, HIFU delivered through high duty cycle can induce foci of temperature elevation and thermal ablation (termed thermal HIFU). We tested the impact of mechanical and thermal HIFU on the anti-glioblastoma effects of the immune checkpoint inhibitor, ipililumab. RESULTS In an in vivomurine glioblastoma model, sites targeted by mechanical HIFU exhibited a 10–100 fold increase in accumulation in tumor infiltrating lymphocytes and interferon-γ (IFN-γ) in the presence of PD-1 blockade. At least 75% of mice engrafted with glioblastomas achieved remission when treated with mechanical HIFU and PD-1 blockade. In contrast, none of the mice treated with single therapies achieved durable remission. Likelihood of remission correlated with the abundance of tumor infiltrating lymphocytes (p< 0.001) and IFN- γ levels (p=0.001). The synergy observed between mechanical HIFU and PD-1 blockade was not seen when combining thermal HIFU and PD-1 blockade, suggesting thermal protein denaturation is prohibitive to immune-stimulatory effects of HIFU. CONCLUSION Mechanical HIFU, but not thermal HIFU, augments the anti-glioblastoma effects of PD-1 blockade. Our findings inform the utility of HIFU as an immune-adjuvant in glioblastoma therapy that can be surgically administered.
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Siedek, Florian, Sin Yuin Yeo, Edwin Heijman, Olga Grinstein, Grischa Bratke, Carola Heneweer, Michael Puesken, Thorsten Persigehl, David Maintz, and Holger Grüll. "Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU): Technical Background and Overview of Current Clinical Applications (Part 1)." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 191, no. 06 (January 10, 2019): 522–30. http://dx.doi.org/10.1055/a-0817-5645.

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Background Extracorporeal high-intensity focused ultrasound (HIFU) is a promising method for the noninvasive thermal ablation of benign and malignant tissue. Current HIFU treatments are performed under ultrasound (US-HIFU) or magnetic resonance (MR-HIFU) image guidance offering integrated therapy planning, real-time control (spatial and temperature guidance) and evaluation. Methods This review is based on publications in peer-reviewed journals addressing thermal ablation using HIFU and includes our own clinical results as well. The technical background of HIFU is explained with an emphasis on MR-HIFU applications. A brief overview of the most commonly performed CE-approved clinical applications for MR-HIFU is given. Results Over the last decade, several HIFU-based applications have received clinical approval in various countries. In particular, MR-HIFU is now approved for the clinical treatment of uterine fibroids, palliation of bone pain, ablation of the prostate and treatment of essential tremor as a first neurological application. Conclusion MR-HIFU is a patient-friendly noninvasive method for thermal ablation which has received clinical approval for several applications. Overall, clinical data demonstrate treatment efficacy, safety and cost efficiency. Key Points: Citation Format
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Youn, Youngwon, Abigail Hellman, Ian Walling, Lucy Gee, Jiang Qian, Clif Burdette, Lance Frith, and Julie G. Pilitsis. "High-Intensity Ultrasound Treatment for Vincristine-Induced Neuropathic Pain." Neurosurgery 83, no. 5 (February 9, 2018): 1068–75. http://dx.doi.org/10.1093/neuros/nyx488.

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Abstract BACKGROUND Vincristine is a commonly used chemotherapeutic agent that results in debilitating untreatable peripheral neuropathy. OBJECTIVE To determine the effects of pulsed high-intensity focused ultrasound (HIFU) on sensory thresholds in a validated vincristine-induced neuropathy (VIN) rodent model. METHODS VIN was induced and mechanical allodynia was confirmed by nociceptive testing. von Frey fibers and Randall-Sellito test were used as measures of innocuous and noxious mechanical thresholds, respectively, and the hot plate test for thermal thresholds. Tests were performed before VIN, after 2 wk of vincristine, at 24, 48, 72, and 120 h after HIFU applied to the left L5 dorsal root ganglia at 3 Watts for 3 min. Comparisons were made between a VIN cohort who underwent HIFU, a VIN cohort who underwent sham HIFU, and naïve rodents who underwent HIFU. RESULTS VIN HIFU rats had significantly increased mechanical thresholds at 24 h (P &lt; .001), 48 h (P = .008), 72 h (P = .003), and 120 h (P = .03) after treatment, when compared to pre-HIFU thresholds. Furthermore, at 24 and 48 h following treatment, VIN HIFU rats had significantly higher innocuous and noxious mechanical thresholds and thermal thresholds than VIN sham HIFU rats (P &lt; .001). Thresholds were not altered in naïve rodents who underwent HIFU. Histological data of L5 dorsal root ganglia of VIN HIFU rats suggest that transient cellular edema resolves by 48 h. CONCLUSION Our data suggest that HIFU increases mechanical and thermal thresholds in VIN rodents. Whether HIFU can preclude the development of reduced thresholds in the VIN model warrants further study.
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Xiao, Juhua, Xin Zhou, Ye Luo, Shuang Wang, Zhili Yang, Yingchun Yi, and Hui Xiong. "A Novel High-Intensity Focused Ultrasound-Treated Herpes Simplex Virus 2 Vaccine Induces Long-Term Protective Immunity against Lethal Challenge in Mice." mSphere 5, no. 6 (December 23, 2020): e00859-20. http://dx.doi.org/10.1128/msphere.00859-20.

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ABSTRACTHigh-intensity focused ultrasound (HIFU), a noninvasive ablation therapy that has been widely used clinically in ablation of solid tumors, induces immune sensitization. We therefore in this study investigated whether HIFU treatment could enhance the efficacy of a herpes simplex virus 2 (HSV-2) vaccine. First, we observed that in HSV-2-positive cervical intraepithelial neoplasia (CIN) II patients, HIFU treatment induced significantly higher anti-HSV-2 neutralization response than surgical removal. Next, we tested the efficacy of HIFU-treated, UV-inactivated HSV-2-infected cells as a proof-of-concept vaccine in mice. Our data showed that HIFU-treated formulation significantly enhanced HSV-2 antibody titers and neutralization titers, compared to UV-, microwave (MW)-, or freeze-thaw (FT)-treated formulations. HIFU treatment also promoted the Th1/2 cell-mediated response. A long-term full protection was observed in mice that received the HIFU-treated formulation, and no weight loss was detected. Our findings indicate that the novel application of HIFU in vaccine production may represent a rational way to improve vaccine efficacy.IMPORTANCE High-intensity focused ultrasound (HIFU) is mainly used in tumor ablation and tumor vaccinology study. It has been shown to induce immune sensitization and enhance tumor responsiveness to other therapies. Our study has shown enhanced anti-HSV-2 response in HIFU-treated CIN II patients. Furthermore, in a murine model, we have demonstrated that HIFU-treated HSV-2 vaccine induced long-term protective immunity against lethal challenge. Our findings indicate that the novel application of HIFU in vaccine production may represent a rational way to improve vaccine efficacy.
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Zhao, Lu-Yan, Jian-Zhong Zou, Zong-Gui Chen, Shan Liu, Jiao Jiao, and Feng Wu. "Acoustic Cavitation Enhances Focused Ultrasound Ablation with Phase-Shift Inorganic Perfluorohexane Nanoemulsions: AnIn VitroStudy Using a Clinical Device." BioMed Research International 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/7936902.

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Purpose.To investigate whether acoustic cavitation could increase the evaporation of a phase-shift inorganic perfluorohexane (PFH) nanoemulsion and enhance high intensity focused ultrasound (HIFU) ablation.Materials and Methods.PFH was encapsulated by mesoporous silica nanocapsule (MSNC) to form a nanometer-sized droplet (MSNC-PFH). It was added to a tissue-mimicking phantom, whereas phosphate buffered saline (PBS) was added as a control (PBS-control). HIFU (Pac=150 W,t=5/10 s) exposures were performed in both phantoms with various duty cycles (DC). US images, temperature, and cavitation emissions were recorded during HIFU exposure. HIFU-induced lesions were measured and calculated.Results.Compared to PBS-control, MSNC-PFH nanoemulsion could significantly increase the volume of HIFU-induced lesion (P<0.01). Peak temperatures were 78.16 ± 5.64°C at a DC of 100%, 70.17 ± 6.43°C at 10%, 53.17 ± 4.54°C at 5%, and 42.00 ± 5.55°C at 2%, respectively. Inertial cavitation was much stronger in the pulsed-HIFU than that in the continuous-wave HIFU exposure. Compared to 100%-DC exposure, the mean volume of lesion induced by 5 s exposure at 10%-DC was significantly larger, but smaller at 2%-DC.Conclusions.MSNC-PFH nanoemulsion can significantly enhance HIFU ablation. Appropriate pulsed-HIFU exposure could significantly increase the volume of lesion and reduce total US energy required for HIFU ablation.
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Gunderman, Anthony, Rudy Montayre, Ashish Ranjan, and Yue Chen. "Review of Robot-Assisted HIFU Therapy." Sensors 23, no. 7 (April 3, 2023): 3707. http://dx.doi.org/10.3390/s23073707.

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This paper provides an overview of current robot-assisted high-intensity focused ultrasound (HIFU) systems for image-guided therapies. HIFU is a minimally invasive technique that relies on the thermo-mechanical effects of focused ultrasound waves to perform clinical treatments, such as tumor ablation, mild hyperthermia adjuvant to radiation or chemotherapy, vein occlusion, and many others. HIFU is typically performed under ultrasound (USgHIFU) or magnetic resonance imaging guidance (MRgHIFU), which provide intra-operative monitoring of treatment outcomes. Robot-assisted HIFU probe manipulation provides precise HIFU focal control to avoid damage to surrounding sensitive anatomy, such as blood vessels, nerve bundles, or adjacent organs. These clinical and technical benefits have promoted the rapid adoption of robot-assisted HIFU in the past several decades. This paper aims to present the recent developments of robot-assisted HIFU by summarizing the key features and clinical applications of each system. The paper concludes with a comparison and discussion of future perspectives on robot-assisted HIFU.
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Yu, Tinghe, and Xiao Fu. "Extracorporeal Ultrasound-Guided High Intensity Focused Ultrasound: Implications from the Present Clinical Trials." Scientific World Journal 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/537260.

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Extracorporeal ultrasound-guided high intensity focused ultrasound (HIFU) has been clinically used for 15 years, and over 36000 cases have been reported. However, there yet lacked a consensus in the clinical values, suggesting the necessity of checking clinical findings. Clinical trials were searched and data reevaluated. HIFU was hardly performed alone; almost all present anticancer means have been applied during an HIFU treatment, and a specific regimen varied between trials; there were heterogeneity and disagreement between trials. The complexity made it difficult to distinguish the effect of HIFU. Based upon evaluable data, the efficacy of HIFU was similar to that of radio frequency, chemoembolization, chemotherapy, radiotherapy, or hormone therapy; a combined therapy did not improve the efficacy. The survival rate of HIFU plus radiotherapy was lower than that of radical surgery in liver cancers. Adverse events had no downtrend in the past years. HIFU was not a standardized procedure where the intensity and insonation mode were modified constantly throughout a treatment, limiting an evaluation from the perspective of ultrasonics. These implied that HIFU should be applied as an alternative at most occasions. The present clinical trials had defects making against the understating of HIFU.
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Dissertations / Theses on the topic "HIFU"

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Rabkin, Brian Alan. "High-intensity focused ultrasound (HIFU) induced hyperechoic regions for the ultrasound guidance of HIFU therapy /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8037.

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Ritchie, Robert Wilson. "Improving clinical outcomes in renal HIFU therapy." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572839.

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The rising incidence of small, asymptomatic renal tumours discovered usmg abdominal imaging during the investigation of unrelated symptoms has fuelled the desire for new therapies which avoid surgical excision. Extracorporeal High Intensity Focused Ultrasound (HIFU) was proposed as one of these modalities but so far clinical research has been ,~." inconclusive. The present work was designed to improve these clii teal outcomes through the conduct of further clinical trials, laboratory based research and the translation of new technology into existing HIFU devices. A Phase II clinical trial of patients (n=13) with newly diagnosed <4cm renal tumours (clinical stage T1a) was designed, peer reviewed and received ethical approval (Ox REC 09/H0606104). Ten of 13 patients underwent renal HIFU using a clinical HIFU device (Model JCIJC200, HAIFU, China). One patient could not be treated due to poor tumour visualisation after anaesthesia and two patients could not be treated as they became unwell before or during anaesthesia. Histological evidence of HIFU ablation in either tumour or normal renal parenchyma was seen in all ten patients. Evidence of sub-total tumour ablation was seen in 8/10 of patients. Grade 1 «50%), 2 (50-90%) & 3 (90-99%) ablation was achieved in 4/10, 3/1 0 & 3/1 0 patients respectively but complete (100%) tumour ablation was not possible. HIFU treatment caused minimal morbidity - no Grade III- V (Clavien-Dindo) complications related to HIFU treatment occurred. Grade I skin pain and induration was seen in 9/1 0 patients; Grade II skin pain occurred in a single patient. Patient demographics, imaging and tumour characteristics were used to design parameters to improve patient selection for renal HIFU. The tumour location, thickness of peri-nephric fat and renal nephrometry score were useful predictors of successful screening for treatment. Page /ii Dr R. W Ritchie Nutiield Department of Surgical Sciences - TT 2012 Abstract Diligent use of these factors could limit unnecessary treatments and Improve ablation outcomes. , It is well known that ultrasound imaging of small renal masses can be challenging. Ultrasound imaging often deteriorates further during HIFU as the abdominal wall and fat tissues swell and cause increased attenuation. This loss of imaging quality was clearly demonstrated in this clinical trial and resulted in the early termination of treatment, before ,#,J' ... ~ .•.. endpoints were reached, in a number of cases. The current clinical method for monitoring the success of HIFU ablation using hyperecho analysis of B-mode ultrasound images is also questionable. Laboratory based studies using ex-vivo bovine liver subjected to HIFU confirmed that hyperecho monitoring had low sensitivity, predictive values and overall accuracy. A novel method of HIFU monitoring - passive mapping of the emissions received from acoustic cavitation activity and other sources of non-linearity during HIFU treatment - is believed to represent a significant opportunity to improve feedback. This technique uses the passively received signature of cavity activity which, when time-reversed, gives high- resolution images of the precise location of the activity. Laboratory-based ex-vivo work, using a commercially available ultrasound system (z.one, Zonare, USA), demonstrates its superiority over hyperecho monitoring. Indeed, thresholds could be applied to successfully predict HIFU ablation with high sensitivity and specificity. This technique was successfully translated into the clinical setting through the design of a Passive Acoustic Mapping (P AM) device. Custom-built receiving elements were applied without limiting the function of the existing HIFU devices. Both pre-clinical and ethically- Page [iii Dr R. W Ritchie Nuffield Department of Surgical Sciences - TT 2012 Abstract approved clinical studies demonstrated its safe integration without significant impact on the device energy output or treatment accuracy. Using similar passive beamfonning algorithms, acoustic cavitation activity was successfully mapped and corresponded with the location of thermal ablation in both ex-vivo tissue phantoms and during clinical HIFU therapy. ,~-' It is believed that the development of new patient selection paral~~tel's will elimil?ate target those patients who are most suitable for renal HIFU - small tumours, minimal peri-nephric fat & low nephrometry score .. The use of P AM will lead to a significant improvement in the efficacy of treatment. It can be successfully applied to existing devices and predicts the location and extent ofHIFU ablation with greater accuracy that existing techniques.
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Greillier, Paul. "Évaluation d’une sonde HIFU transoesophagienne sur coeur battant." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1342/document.

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Une sonde HIFU transoesophagienne a été proposée comme une alternative aux traitements actuels de fibrillation auriculaire. Le présent travail décrit une étude de faisabilité de l'ablation thermique transoesophagienne sur des coeurs battant in vivo chez des primates non humains et ex vivo sur un cœur isolé
Transesophageal HIFU was proposed as an alternative to the current atrial fibrillation treatments. The present work described a feasibility study of transesophageal thermal ablation in the heart on beating hearts in vivo non-human primates and ex vivo on isolated heart
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Greillier, Paul. "Évaluation d’une sonde HIFU transoesophagienne sur coeur battant." Electronic Thesis or Diss., Lyon, 2017. http://www.theses.fr/2017LYSE1342.

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Une sonde HIFU transoesophagienne a été proposée comme une alternative aux traitements actuels de fibrillation auriculaire. Le présent travail décrit une étude de faisabilité de l'ablation thermique transoesophagienne sur des coeurs battant in vivo chez des primates non humains et ex vivo sur un cœur isolé
Transesophageal HIFU was proposed as an alternative to the current atrial fibrillation treatments. The present work described a feasibility study of transesophageal thermal ablation in the heart on beating hearts in vivo non-human primates and ex vivo on isolated heart
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Souris, Line. "Suivi en imagerie par résonance magnétique de la température et des propriétés viscoélastiques des tissus cérébraux dans le cadre des thermothérapies." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00630658.

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Mon travail de thèse se place dans le cadre du projet ANR TUCCIRM de développement d'un système de thérapie par ultrasons focalisés de haute intensité (HIFU) dédié au cerveau implantable dans un IRM clinique 1,5 T. Les développements IRM ont été l'objet de mon travail. Dans un premier temps, l'IRM a été utilisée pour suivre l'évolution en température des tissus en cours de traitement. Pour cela, nous avons tout d'abord réalisé une étude d'optimisation et de comparaison de séquences de thermométrie basées sur le principe du décalage chimique (PRFS). Puis, nous avons optimisé le rapport signal sur bruit pour améliorer la qualité des images ainsi que la précision en température. Ces développements ont été appliqués au cours de tests HIFU suivi par IRM de têtes de cadavres humains.Dans un deuxième temps, l'IRM a été utilisée pour caractériser la viscoélasticité des tissus cérébraux par la technique d'élastograhie par résonance magnétique. Ces propriétés changeant avec la température, cette méthode permettrait de suivre l'état des tissus pendant le traitement HIFU pour en déterminer l'effet thermique. Dans ce contexte, nous avons développé un nouveau concept de générateur d'onde, testé ensuite sur six rats in vivo.
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Chauhan, Sunita. "The applications of HIFU and robotic technology in surgery." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313994.

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Ye, Guoliang. "Model-based ultrasonic temperature estimation for monitoring HIFU therapy." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:6f4c4f84-3ca6-46f2-a895-ab0aa3d9af51.

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High Intensity Focused Ultrasound (HIFU) is a new cancer thermal therapy method which has achieved encouraging results in clinics recently. However, the lack of a temperature monitoring makes it hard to apply widely, safely and efficiently. Conventional ultrasonic temperature estimation based on echo strain suffers from artifacts caused by signal distortion over time, leading to poor estimation and visualization of the 2D temperature map. This thesis presents a novel model-based stochastic framework for ultrasonic temperature estimation, which combines the temperature information from the ultrasound images and a theoretical model of the heat diffusion. Consequently the temperature estimation is more consistent over time and its visualisation is improved. There are 3 main contributions of this thesis related to: improving the conventional echo strain method to estimate temperature, developing and applying approximate heat models to model temperature, and finally combining the estimation and the models. First in the echo strain based temperature estimation, a robust displacement estimator is first introduced to remove displacement outliers caused by the signal distortion over time due to the thermo-acoustic lens effect. To transfer the echo strain to temperature more accurately, an experimental method is designed to model their relationship using polynomials. Experimental results on a gelatine phantom show that the accuracy of the temperature estimation is of the order of 0.1 ◦C. This is better than results reported previously of 0.5 ◦C in a rubber phantom. Second in the temperature modelling, heat models are derived approximately as Gaussian functions which are mathematically simple. Simulated results demonstrate that the approximate heat models are reasonable. The simulated temperature result is analytical and hence computed in much less than 1 second, while the conventional simulation of using finite element methods requires about 25 minutes under the same conditions. Finally, combining the estimation and the heat models is the main contribution of this thesis. A 2D spatial adaptive Kalman filter with the predictive step defined by the shape model from the heat models is applied to the temperature map estimated from ultrasound images. It is shown that use of the temperature shape model enables more reliable temperature estimation in the presence of distorted or blurred strain measurements which are typically found in practice. The experimental results on in-vitro bovine liver show that the visualisation on the temperature map over time is more consistent and the iso-temperature contours are clearly visualised.
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Peters, Kristina. "Experimentelle Untersuchungen zur nichtinvasiven Gewebeablation durch hochenergetischen fokussierten Ultraschall (HIFU)." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-66433.

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Pather, Paramaselvan. "A robotic system for HIFU surgery applied to liver tumours." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251651.

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Collin, James R. T. "Detection and interpretation of thermally relevant cavitation during HIFU exposure." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526574.

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Books on the topic "HIFU"

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Satō, Atsushi. Zō no hifu: Zou no hifu. Tōkyō: Shinchōsha, 2021.

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Dazai, Osamu. Hifu to kokoro: Shōsetsushū. Tōkyō: Nihon Kindai Bungakukan, 1992.

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1950-, Kobayashi Yasuo, and Matsuura Hisaki, eds. Shintai, hifu no shūjigaku. Tōkyō: Tōkyō Daigaku Shuppankai, 2000.

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Akasaka, Mari. Chō no hifu no shita. Tōkyō: Kawade Shobō Shinsha, 1997.

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1965-, Satō Naoki, Geissmar Christoph, Hijiya-Kirschnereit Irmela, and Kokuritsu Seiyō Bijutsukan, eds. Hifu no sōzōryoku =: The faces of skin. Tōkyō: Kokuritsu Seiyō Bijutsukan, 2001.

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1967-, Hirayoshi Yukihiro, and Kokuritsu Kokusai Bijutsukan (Japan), eds. Gendai bijutsu no hifu =: Skin of/in contemporary art. [Osaka]: Kokuritsu Kokusai Bijutsukan, 2007.

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Snitselaar, Nicole. Hiku. Woodbridge, England: Top That, 2014.

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Āhameda, Humāẏūna. Himu. Ḍhākā: Pratīka, 1993.

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ʻAbdulqadīru, Kāñon, ed. Qaumiyata: Hiku tajziyo, hiku mutālaʻo. Haidarābād [Pakistan]: Sindhu Naishnal Ikaiḍamī, 1985.

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1954-, Joyu Tāju, ed. Shāhu Lat̤īfu hiku taḥruk, hiku taḥrīku. Ḥaidarābādu [Sind]: Bhaṭu Shahu S̲aqāftī Markazu, 2002.

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Book chapters on the topic "HIFU"

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Winter, Patrick M., Gregory M. Lanza, Samuel A. Wickline, Marc Madou, Chunlei Wang, Parag B. Deotare, Marko Loncar, et al. "Pulsed HIFU." In Encyclopedia of Nanotechnology, 2180. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-90-481-9751-4_100688.

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Zhu, Xiaogang, Felix Wong, and Min Xue. "HIFU Ablation." In Adenomyosis, 129–35. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-33-4095-4_14.

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Crouzet, Sébastien. "Salvage Focal HIFU." In Focal Therapy of Prostate Cancer, 95–98. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-14160-2_9.

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Wong, Felix, Lian Zhang, and Zhibiao Wang. "Adenomyosis and HIFU Ablation." In Focused Ultrasound Surgery in Gynecology, 63–70. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-0939-8_5.

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Wong, Felix, Lian Zhang, and Zhibiao Wang. "Complications of HIFU Ablation." In Focused Ultrasound Surgery in Gynecology, 71–79. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-0939-8_6.

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Bhansali, Anita P., and Ryder P. Gwinn. "Ablation: Radiofrequency, Laser, and HIFU." In Stereotactic and Functional Neurosurgery, 223–33. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-34906-6_16.

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Wong, Felix, Lian Zhang, and Zhibiao Wang. "Uterine Fibroids and HIFU Ablation." In Focused Ultrasound Surgery in Gynecology, 37–61. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-0939-8_4.

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Wong, Felix, Lian Zhang, and Zhibiao Wang. "Other Issues of HIFU Treatment." In Focused Ultrasound Surgery in Gynecology, 89–92. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-0939-8_8.

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Crouzet, Sebastien, Olivier Rouvière, Cyril Lafond, Jean-Yves Chapelon, and Albert Gelet. "Focal High-Intensity Focused Ultrasound (HIFU)." In Technical Aspects of Focal Therapy in Localized Prostate Cancer, 137–51. Paris: Springer Paris, 2014. http://dx.doi.org/10.1007/978-2-8178-0484-2_12.

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ter Haar, Gail. "HIFU Tissue Ablation: Concept and Devices." In Advances in Experimental Medicine and Biology, 3–20. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-22536-4_1.

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Conference papers on the topic "HIFU"

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Yang, Kun, Qiang Li, and Xiaowei Zhou. "Adaptive eigen subspace projection for suppressing HIFU interference." In 2024 IEEE Ultrasonics, Ferroelectrics, and Frequency Control Joint Symposium (UFFC-JS), 1–4. IEEE, 2024. https://doi.org/10.1109/uffc-js60046.2024.10794116.

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Zhou, Yingying, Kun Yang, Jiahong Xu, Dejia Cai, and Xiaowei Zhou. "HIFU ablation monitoring with weighted ultrasound entropy imaging." In 2024 IEEE Ultrasonics, Ferroelectrics, and Frequency Control Joint Symposium (UFFC-JS), 1–4. IEEE, 2024. https://doi.org/10.1109/uffc-js60046.2024.10793626.

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Wang, Hai, and Wei Li. "Selective HIFU Foaming to Fabricate Porous Polymer for Tissue Engineering Scaffolds." In ASME 2006 International Manufacturing Science and Engineering Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/msec2006-21043.

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A novel technique is presented in this paper for the fabrication of tissue engineering scaffolds using the High Intensity Focused Ultrasound (HIFU). This acoustic method is a solvent-free, highly efficient and low cost process that has the potential in scaffold-based tissue engineering. HIFU fabrication technique is capable of creating hierarchically-structured porous polymeric materials, which have various topographical features at different length scales. This will in turn affect the cellular response and behavior of certain type of cells, such as the integration and growth of smooth muscle cells (SMCs). In this study, the effect of HIFU porous polymer fabrication was investigated. Scanning-mode HIFU insonation was performed in the HIFU polymer foaming experiments. The acoustic power and the scanning speed were chosen as the parameters and varied in different groups of experiments. The created microstructures were characterized using the scanning electron microscopy (SEM). The fabricated samples were used for cell culture studies with human aortic SMCs (Passage 4). It was found that the selective HIFU foaming process could be used to create hierarchical structures by choosing appropriate ultrasound parameters. The SMCs were viable on the HIFU-created porous PMMA specimens, and the topographical nature of a HIFU-created porous structure affected the cellular response of SMCs.
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Yuan, Fang, Chris Pua, Pei Zhong, and Yunbo Liu. "HIFU-Induced Gene Activation in a Cell-Embedded Tissue Mimicking Phantom." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-43996.

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The synergistic integration of high intensity focused ultrasound (HIFU) thermal ablation and HIFU-induced gene therapy represents a promising approach in improving the overall efficacy and quality of cancer therapy. Previous studies have demonstrated that HIFU can induce GFP gene activation under the control of hsp70B promoter in a murine tumor model [1]. Thermal stress has been identified as the primary mechanism to regulate the gene expression. However, the natural heterogeneity and opacity of solid tumors has hindered direct correlation of site-specific gene expression level with in situ thermal dosimetry. We have developed a homogeneous and transparent cell-embedded tissue mimicking phantom as an alternative for simultaneous assessment of temperature distribution, HIFU lesion formation, and gene expression.
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Park, Chan Yuk, Da Sol Kwon, Jin Ho Sung, and Jong Seob Jeong. "High Intensity Focused Ultrasound Transducer Using Inversion Layer Technique for Ultrasound Therapy." In 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3369.

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Recently, high intensity focused ultrasound (HIFU) has been used for non-invasive surgery of prostate, uterus, and brain. However, a HIFU therapy is suffered from relatively long surgical time mainly due to small focal area per each sonication. In order to solve this problem, a HIFU therapy using multi-frequency was suggested by several researchers, and they demonstrated that this technique can increase the area of the coagulated lesion due to enhanced cavitation effect compared to single-frequency HIFU [1–3]. To generate multi-frequency especially dual-frequency, dual-element and dual-layer HIFU transducers have been developed and provided an expanded lesion size [1–3]. In this study, we present an alternative technique of making dual-frequency HIFU transducer using inversion layer technique. Generally, a single layer piezoelectric element can excite the strong fundamental resonance (f0) and the weak odd-order harmonic resonance (3f0) [4]. In the inversion layer technique, on the other hand, a piezoelectric component consisting of two piezo-ceramic plates bonded together with opposite poling directions and different thicknesses can produce the relatively strong even-order harmonic (2f0) in addition to the fundamental resonance [5]. Additionally, only a pair of electrode at the outside of the each piezo-ceramic plate is required to stimulate dual-frequency ultrasound while two pairs of electrodes are typically required for conventional dual-element and dual-layer transducers [2,3]. A specially designed prototype HIFU transducer was built, and we verified that the dual-frequency ultrasound was successfully generated through electrical impedance and pulse-echo response measurements.
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Okita, Kohei, Ryuta Narumi, Takashi Azuma, Shu Takagi, and Yoichiro Matsumoto. "Modeling and Simulation of High-Intensity Focused Ultrasound Therapy for Breast Cancer." In ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/fmd2013-16055.

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Therapeutic application of ultrasound is of interest for a tumor treatment, thrombolysis, drag delivery, blood-brain barrier opening and so on. High-intensity focused ultrasound (HIFU) therapy has been developed as the noninvasive treatment deep cancers in particular. Issues as the defocusing and distortion of ultrasound in the body and the long treatment time in current HIFU should be resolved quickly. Numerical simulation is required for the early development of the advance HIFU system.
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Dasgupta, Subhashish, Janaka Wansapura, Prasanna Hariharan, Ron Pratt, David Witte, Matthew R. Myers, and Rupak K. Banerjee. "Determination of Lesion Size as Function of HIFU Sonication Time Using MRI Monitored HIFU Ablations." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-205163.

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The purpose of this study is to determine the dependence of the size of the thermal lesion on sonication time in an ex-vivo porcine liver sample during simulated High Intensity Focused Ultrasound (HIFU) tissue ablation. MRI guided HIFU ablations were performed on a freshly excised porcine liver sample at 70 W acoustic power. The size of the lesion (ablated zone) was measured at sonication times, 20 s, 30 s and 40 s. Numerical calculations were performed to validate the experimental lesion size. Also, a histology study of the ablated liver sample was performed to confirm cell necrosis within the ablated zones. It was found that the HIFU induced lesion size is strongly dependant on sonication time and lesion size almost doubles (increases from 0.368 to 0.715 cm2) as sonication time increases from 20s to 40s. The area of lesions, determined experimentally, agreed within 5% with results of numerical calculations.
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Arif, Tariq M., and Zhiming Ji. "A Fast Estimation Model for Angular Spectrum Based Focused Ultrasound Wave Simulation in Layered Tissue Media." In ASME 2019 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/imece2019-11088.

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Abstract High-Intensity Focused Ultrasound (HIFU) is a popular non-invasive therapeutic tool and widely used in many clinical settings. The simulation models used for HIFU responses are computationally expensive and time-consuming. Among many numerical HIFU simulation methods, the Rayleigh-Sommerfeld approach is considered to be a reliable one. However, Rayleigh-Sommerfeld is suitable for homogeneous medium, and for a heterogeneous media, many approximations should be made in order to reduce the calculation time. In this study, we propose a fast methodology for estimating focused ultrasound pressure-temperature field responses through layered tissue media. A computationally efficient nonlinear angular spectrum-based method that can address the effects of varying attenuations, reflections and refractions from tissue layers is implemented to calculate reference datasets. From the simulation datasets, a profile function coupled with a GUI code is constructed for estimating the pressure-temperature response by using a Gaussian function and a Genetic Algorithm. The HIFU response model illustrated in this study can be advantageous and time-effective when multiple simulations are required on a similar complex patient model, and it can be used to guide and reduce the sets of simulations required for planning HIFU treatment.
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Jungsoon Kim, Moojoon Kim, and Kanglyeol Ha. "HIFU transducer with controllable curvature." In 2013 IEEE International Ultrasonics Symposium (IUS). IEEE, 2013. http://dx.doi.org/10.1109/ultsym.2013.0290.

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King, Randy L., Bruce A. Herman, Subha Maruvada, Keith A. Wear, and Gerald R. Harris. "Development of a HIFU Phantom." In 6TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. AIP, 2007. http://dx.doi.org/10.1063/1.2744296.

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Reports on the topic "HIFU"

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Chen, Yishan, Zhenhong Wang, Xi Xie, Jingsong YI, Shunhe Lin, and Sun-Wei Guo. HIFU babies: Dose the high-intensity focused ultrasound (HIFU) treatment of adenomyosis improve pregnancy? INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2023. http://dx.doi.org/10.37766/inplasy2023.9.0097.

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Li, Yu. Noninvasive MR-Guided HIFU Therapy of TSC-Associated Renal Angiomyolipomas. Fort Belvoir, VA: Defense Technical Information Center, September 2014. http://dx.doi.org/10.21236/ada609479.

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Li, Yu. Non-invasive MR-guided HIFU Therapy of TSC-Associated Renal Angiomyolipomas. Fort Belvoir, VA: Defense Technical Information Center, July 2012. http://dx.doi.org/10.21236/ada566994.

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Li, Yu. Non-invasive MR-guided HIFU Therapy of TSC-Associated Renal Angiomyolipomas. Fort Belvoir, VA: Defense Technical Information Center, July 2013. http://dx.doi.org/10.21236/ada586278.

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Li, Yanhui, and Cuiju Hua. Comparison of the Efficacy and Subsequent Pregnancy Outcomes of High-intensity Focused Ultrasound and Uterine Artery Embolization in the Chinese Population: Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2022. http://dx.doi.org/10.37766/inplasy2022.10.0053.

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Review question / Objective: The combination of high-intensity focused ultrasound (HIFU), and uterine artery embolization (UAE) with uterine curettage has been proposed as a therapy strategy for cesarean scar pregnancy (CSP), which can provide a high success rate while reducing blood loss, adverse events, hospital time and cost. Therefore, we performed this meta-analysis to assess the effects of this combination therapy on the efficacy, safety, and pregnancy outcomes in patients with CSP. Eligibility criteria: (1) Study design: Cohort, case-control, or randomized controlled trials that compare the efficacy, safety, and recurrence of UAE combined with curettage and HIFU combined with uterine scraping in the treatment of cesarean section scar pregnancy. (2) Outcome: Success rate, blood loss, time of β-hCG normalization, adverse events, length of stay, hospital costs, menstrual recovery, re-pregnancy status, and pain score.
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O'Neill, Brian E. Treatment of Breast Tumors using Pulsed HIFU for Delivery and Activation of Sonosensitizers. Fort Belvoir, VA: Defense Technical Information Center, February 2010. http://dx.doi.org/10.21236/ada524139.

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Kim, Eun-Jin, Youngshin Shim, and Sang Yeon Min. Safety and Efficacy of Herbal Medicine for Symptom Management After HIFU Treatment in Adenomyosis: A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2025. https://doi.org/10.37766/inplasy2025.3.0088.

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Zhou, Yushan, Zubang Zhou, Minghua Zhang, Ya’e Xue, Xueting Zhang, and Li Wang. Comparison of prognosis among patients with colorectal cancer liver metastases treated by surgical resection, radiofrequency ablation and HIFU: a protocol for network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2021. http://dx.doi.org/10.37766/inplasy2021.5.0044.

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Keefe, D. HIF/HIFAR accomplishments: A synopsis (December 1988). Office of Scientific and Technical Information (OSTI), December 1988. http://dx.doi.org/10.2172/6134974.

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Logan, Grant, Joe Kwan, John Barnard, Alex Friedman, Erik Gilson, Matthaeus Leitner, Will Waldron, and Frank Bieniosek. HIFS VNL Monthly Progress Report Preparation for NDCX-II Project. Office of Scientific and Technical Information (OSTI), May 2009. http://dx.doi.org/10.2172/981731.

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