Relevant bibliographies by topics / Higenamine

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  1. Journal articles
  2. Dissertations / Theses
  3. Conference papers

Academic literature on the topic 'Higenamine'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Higenamine"

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Shi, Hanghao, Long Cheng, Huixin Li, et al. "A Narrative Review on Higenamine: Pharmacological Properties and Clinical Applications." Nutrients 17, no. 6 (2025): 1030. https://doi.org/10.3390/nu17061030.

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Background: Higenamine, a bioactive alkaloid derived from plants such as Aconitum and Annona squamosa, has been traditionally used in Chinese medicine for treating heart diseases like bradycardia, arrhythmia, and heart failure. It exhibits multiple pharmacological effects, including anti-oxidative stress, improved cellular energy metabolism, anti-apoptosis, and enhanced erectile dysfunction. Aim and Methods: To investigate the reasons for these functions of higenamine and its application in the clinic, the literature of the database was searched and read in this study. Results: As a non-select
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Geng, Chao, та Shaowu Ou. "Higenamine Induces Glioma Cell Death by Modulating Nuclear Factor-κB Nuclear Translocation, Phosphoinositide-3-Kinase/Protein Kinase B Signaling and Caspase Cascade". Current Topics in Nutraceutical Research 19, № 3 (2020): 317–25. http://dx.doi.org/10.37290/ctnr2641-452x.19:317-325.

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We have investigated the effectiveness of higenamine in the treatment of malignant glioma, and explored its possible mechanism in C6 glioma cells. The efficacy of higenamine on viability of cells, apoptosis, cell cycle arrest, DNA fragmentation, and biochemical markers was examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry, enzyme-linked immunosorbent assay, and Western blotting. The biochemical markers investigated included the effect of higenamine on the expression of phosphoinositide-3-kinase/protein kinase B, B-cell lymphoma 2, BCL2- associated X
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Nuntawong, Poomraphie, Hiroyuki Tanaka, Seiichi Sakamoto, and Satoshi Morimoto. "ELISA for the Detection of the Prohibited Doping Agent Higenamine." Planta Medica 86, no. 11 (2020): 760–66. http://dx.doi.org/10.1055/a-1181-2084.

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AbstractHigenamine is a natural benzyltetrahydroisoquinoline alkaloid produced by various plants. In the World Anti-Doping Agency report of 2020, higenamine is classified as a class S3 (selective and nonselective β2-agonist) prohibited substance. To minimize the problems resulting from the misuse of higenamine-containing products as well as from the abuse of doping agents in sport, numerous higenamine-detection methods have been investigated. In the present study, a monoclonal antibody against the (S)-enantiomer of higenamine was successfully produced and applied in the indirect competitive EL
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Rangelov Kozhuharov, Vanya, Kalin Ivanov, and Stanislava Ivanova. "Higenamine in Plants as a Source of Unintentional Doping." Plants 11, no. 3 (2022): 354. http://dx.doi.org/10.3390/plants11030354.

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Background: Higenamine is a β2 agonist of plant origin. The compound has been included in WADA’s prohibited list since 2017. Higenamine may be detected in different plants and many food supplements of natural origin. Methods: Our literature search was conducted through PubMed, Science Direct, Google Scholar, and Web of Science studies investigating the presence of higenamine in plants that are used in traditional folk medicine or included in food supplements. Our study aimed to assess the risk of adverse analytical findings caused by higenamine-containing plants. Results: Based on our literatu
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Xie, Yulu, Xican Li, Jingyu Chen, Yuman Deng, Wenbiao Lu, and Dongfeng Chen. "pH Effect and Chemical Mechanisms of Antioxidant Higenamine." Molecules 23, no. 9 (2018): 2176. http://dx.doi.org/10.3390/molecules23092176.

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In this article, we determine the pH effect and chemical mechanism of antioxidant higenamine by using four spectrophotometric assays: (1) 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide radical (PTIO•)-scavenging assay (at pH 4.5, 6.0, and 7.4); (2) Fe3+-reducing power assay; (3) Cu2+-reducing power assay; and (4) 1,1-diphenyl-2-picryl-hydrazyl (DPPH•)-scavenging assay. The DPPH•-scavenging reaction product is further analyzed by ultra-performance liquid chromatography, coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC-ESI-Q-TOF-MS/MS) technol
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Shailaja, Amol D., and Jaykumar S. Pramodkumar. "Isolation, In-silico Studies, and Biological Evaluation of Higenamine from Annona squamosa L. against Breast Cancer." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 14, no. 04 (2023): 1039–47. http://dx.doi.org/10.25258/ijpqa.14.4.34.

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The efficacy of Annona squamosa L. in cancer treatment has been documented, inspiring the authors to investigate the plant further for potential novel anticancer compounds. Therefore, the current study aimed to isolate and characterize Higenamine from leaves extract of A. squamosa L. and studied for the in-vitro cancer cell line and molecular docking. The high performance liquid chromatography (HPLC) and thin layer chromatography (TLC) method development of A. squamosa L. leaves extract furnished Higenamine of which characterization was established by HPLC, infrared radiation (IR), liquid chro
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Kim, DongHyun, JeaHyeok Yun, Eunmiri Roh, Han-Seung Shin, and Jong-Eun Kim. "Higenamine Reduces Fine-Dust-Induced Matrix Metalloproteinase (MMP)-1 in Human Keratinocytes." Plants 12, no. 13 (2023): 2479. http://dx.doi.org/10.3390/plants12132479.

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Environmental pollutants such as fine dust are increasingly linked to premature skin aging. In this study, we investigated the protective effects of higenamine, a natural plant alkaloid, against fine-dust-induced skin aging in human keratinocytes (HaCaT cells). We found that higenamine significantly attenuated fine-dust-induced expression of matrix metalloproteinase-1 (MMP-1), a key enzyme involved in collagen degradation. Furthermore, higenamine was found to modulate fine-dust-induced AP-1 and NF-κB transactivation, which are crucial factors for MMP-1 transcription. Higenamine also impeded fi
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Yen, Ching-Chi, Chun-Wei Tung, Chih-Wei Chang, Chin-Chuan Tsai, Mei-Chich Hsu, and Yu-Tse Wu. "Potential Risk of Higenamine Misuse in Sports: Evaluation of Lotus Plumule Extract Products and a Human Study." Nutrients 12, no. 2 (2020): 285. http://dx.doi.org/10.3390/nu12020285.

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Since 2017, higenamine has been added to the World Anti-Doping Agency (WADA) prohibited list as a β2-agonist prohibited at all times for sportspersons. According to WADA’s report, positive cases of higenamine misuse have been increasing yearly. However, higenamine occurs naturally in the Chinese herb lotus plumule—the green embryo of lotus (Nelumbo nucifera Gaertn) seeds—commercially available as concentrated powder on the Asian market. This study evaluated the major phytochemical components of lotus plumule products using an appropriate extraction method, followed by a human study in which th
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9

Chen, Yan-Ling, Xiao-Dong Zhuang, Zhi-Wei Xu, et al. "Higenamine Combined with [6]-Gingerol Suppresses Doxorubicin-Triggered Oxidative Stress and Apoptosis in Cardiomyocytes via Upregulation of PI3K/Akt Pathway." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–14. http://dx.doi.org/10.1155/2013/970490.

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Sini decoction is a well-known formula of traditional Chinese medicine, which has been used to treat cardiovascular disease for many years. Previously, we demonstrated that Sini decoction prevented doxorubicin-induced heart failure in vivo. However, its active components are still unclear. Thus, we investigated the active components of Sini decoction and their cardioprotective mechanisms in the in vitro neonatal rat cardiomyocytes and H9c2 cell line models of doxorubicin-induced cytotoxicity. Our results demonstrated that treatment with higenamine or [6]-gingerol increased viability of doxorub
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10

Bloomer, RJ, JM Schriefer, and TA Gunnels. "Clinical safety assessment of oral higenamine supplementation in healthy, young men." Human & Experimental Toxicology 34, no. 10 (2015): 935–45. http://dx.doi.org/10.1177/0960327114565490.

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Objective: Higenamine, an herbal agent also known as norcoclaurine, is thought to stimulate β-androgenic receptors and possess lipolytic activity. It is currently making its way into the dietary supplement market. To our knowledge, no studies have been conducted to determine the safety profile of oral higenamine when used alone and in conjunction with other commonly used lipolytic agents. Methods: Forty-eight men were assigned to ingest either a placebo, higenamine, caffeine, or higenamine + caffeine + yohimbe bark extract daily for a period of 8 weeks. Before and after 4 and 8 weeks of supple
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Dissertations / Theses on the topic "Higenamine"

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LO, CHI-FANG, and 羅吉方. "Pharmacokinetic and Metabolic Studies of Higenamine in Rabbits." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/y233ed.

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博士<br>台北醫學院<br>藥學類<br>84<br>Pharmacokinetic and Metabolic Studies of Higenamine in Rabbits ((+/-)-Higenamine, (+/-)- HG), a potent cardiotonic principle, is isolated as a racemate from Aconitum japonicium, and other natural resource such as Annona squamosa, Asiasarum heterotropodes, and Gnetum parvifolium. It acts directly on the adrenergic beta-1 and beta-2 receptors. (+)-HG is isolated from Nelumbo nucifera as smooth muscle relaxant. A method for the pharmacokinetic studies of HG i
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Conference papers on the topic "Higenamine"

1

Rasic Ozegovic, Jelena, Marija Takic, Nevena Ivanovic, Danijela Ristic-Medic, Milica Vukasinovic Vesic, and Brizita Djordjevic. "The Effect of Higenamine Supplementation on the Fatty Acid Profiles of Serum Phospholipids." In European Nutrition Conference. MDPI, 2024. http://dx.doi.org/10.3390/proceedings2023091213.

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