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1

Moore, Lorna G. "Measuring high-altitude adaptation." Journal of Applied Physiology 123, no. 5 (2017): 1371–85. http://dx.doi.org/10.1152/japplphysiol.00321.2017.

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High altitudes (>8,000 ft or 2,500 m) provide an experiment of nature for measuring adaptation and the physiological processes involved. Studies conducted over the past ~25 years in Andeans, Tibetans, and, less often, Ethiopians show varied but distinct O2transport traits from those of acclimatized newcomers, providing indirect evidence for genetic adaptation to high altitude. Short-term (acclimatization, developmental) and long-term (genetic) responses to high altitude exhibit a temporal gradient such that, although all influence O2content, the latter also improve O2delivery and metabolism
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2

Bakker-Dyos, J., S. Vanstone, and AJ Mellor. "High altitude adaptation and illness: military implications." Journal of The Royal Naval Medical Service 102, no. 1 (2016): 33–39. http://dx.doi.org/10.1136/jrnms-102-33.

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AbstractBritish military personnel are frequently exposed to high altitude (HA) (>1500m). Operations in Afghanistan have occurred at altitudes of up to 3000m and there remains the possibility of rapid deployment of non-acclimatised troops to HA areas. British military personnel also deploy to HA frequently on Adventurous Training (AT) and there are numerous expeditions every year to the Greater Ranges. As such, there remains a reasonable likelihood of the development of high altitude illness (HAI) with potentially life-threatening consequences. This article aims to provide an overview of th
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3

Gonzales, Gustavo. "Importance of Testosterone on Adaptation at High Altitude." International Journal of Medical and Surgical Sciences 2, no. 4 (2018): 689–97. http://dx.doi.org/10.32457/ijmss.2015.043.

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Adaptation or natural acclimatization results from the interaction between genetic variations and acclimatization resulting in individuals with ability to live and reproduce without problems at high altitudes. Testosterone is a hormone that increases erythropoiesis and inhibits ventilation. It could therefore, be associated to the adaptation to high altitudes. Excessive erythrocytosis, which in turn will develop chronic mountain sickness is caused by low arterial oxygen saturation and ventilatory inefficiency and blunted ventilatory response to hypoxia. Testosterone is elevated in natives at h
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4

Stobdan, Tsering, Jayashree Karar, and M. A. Qadar Pasha. "High Altitude Adaptation: Genetic Perspectives." High Altitude Medicine & Biology 9, no. 2 (2008): 140–47. http://dx.doi.org/10.1089/ham.2007.1076.

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5

Wu, Tianyi, and Bengt Kayser. "High Altitude Adaptation in Tibetans." High Altitude Medicine & Biology 7, no. 3 (2006): 193–208. http://dx.doi.org/10.1089/ham.2006.7.193.

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6

O'Brien, Katie A., Tatum S. Simonson, and Andrew J. Murray. "Metabolic adaptation to high altitude." Current Opinion in Endocrine and Metabolic Research 11 (April 2020): 33–41. http://dx.doi.org/10.1016/j.coemr.2019.12.002.

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7

Scheinfeldt, Laura B., and Sarah A. Tishkoff. "Living the high life: high-altitude adaptation." Genome Biology 11, no. 9 (2010): 133. http://dx.doi.org/10.1186/gb-2010-11-9-133.

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8

Huerta-Sánchez, Emilia, and Fergal P. Casey. "Archaic inheritance: supporting high-altitude life in Tibet." Journal of Applied Physiology 119, no. 10 (2015): 1129–34. http://dx.doi.org/10.1152/japplphysiol.00322.2015.

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The Tibetan Plateau, often called the roof of the world, sits at an average altitude exceeding 4,500 m. Because of its extreme altitude, the Plateau is one of the harshest human-inhabited environments in the world. This, however, did not impede human colonization, and the Tibetan people have made the Tibetan Plateau their home for many generations. Many studies have quantified their markedly different physiological response to altitude and proposed that Tibetans were genetically adapted. Recently, advances in sequencing technologies led to the discovery of a set of candidate genes which harbor
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9

Aryal, Binod. "Effects of high altitude in pregnancy: an opportunity of research in KAHS." Journal of Karnali Academy of Health Sciences 1, no. 3 (2018): 1–2. http://dx.doi.org/10.3126/jkahs.v1i3.24145.

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Pregnancy is a special condition in a women’s life with unique physiological changes. There has been some research on physiological changes in human body in high altitude; however, there are many things still unknown about pregnancy at high altitude. It is an estimation that about 140 million people worldwide live in high altitude of above 2500 m, and it is believed that the hypobaric hypoxia of pregnancy at high altitude is the most common cause for maternofetal hypoxia. It has been seen that the babies born at high altitude are smaller, and the degree of smallness is inversely correlated wit
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10

Zubieta-Castillo, Gustavo, and Gustavo Zubieta-Calleja. "Polyerythrocythemia and Adaptation to High Altitude." Wilderness & Environmental Medicine 26, no. 1 (2015): e4. http://dx.doi.org/10.1016/j.wem.2014.11.016.

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11

Wilson, Megan J., Colleen Glyde Julian, and Robert C. Roach. "Genomic Analysis of High-Altitude Adaptation." Current Sports Medicine Reports 10, no. 2 (2011): 59–61. http://dx.doi.org/10.1249/jsr.0b013e31820f21a2.

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12

Moore, Lorna G. "Human Genetic Adaptation to High Altitude." High Altitude Medicine & Biology 2, no. 2 (2001): 257–79. http://dx.doi.org/10.1089/152702901750265341.

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13

Getu, Ayechew. "Ethiopian Native Highlander’s Adaptation to Chronic High-Altitude Hypoxia." BioMed Research International 2022 (April 15, 2022): 1–5. http://dx.doi.org/10.1155/2022/5749382.

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People living in a high-altitude environment have distinct lifelong challenges. Adaptive mechanisms have allowed high-altitude residents to survive in a low-oxygen environment for thousands of years. The purpose of this review was to provide a brief review of the Ethiopian native highlanders’ adaptive mechanisms to chronic hypoxia problems at high altitude. Traditionally, an elevated hemoglobin concentration has been considered as a hallmark of lifelong adaptation to high-altitude hypoxia, though this notion has been refuted recently as a result of the establishment of the alternative adaptive
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14

Guan, Jiuqiang, Keren Long, Jideng Ma, et al. "Comparative analysis of the microRNA transcriptome between yak and cattle provides insight into high-altitude adaptation." PeerJ 5 (November 2, 2017): e3959. http://dx.doi.org/10.7717/peerj.3959.

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Extensive and in-depth investigations of high-altitude adaptation have been carried out at the level of morphology, anatomy, physiology and genomics, but few investigations focused on the roles of microRNA (miRNA) in high-altitude adaptation. We examined the differences in the miRNA transcriptomes of two representative hypoxia-sensitive tissues (heart and lung) between yak and cattle, two closely related species that live in high and low altitudes, respectively. In this study, we identified a total of 808 mature miRNAs, which corresponded to 715 pre-miRNAs in the two species. The further analy
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15

Rupert, J. L., and P. W. Hochachka. "Genetic approaches to understanding human adaptation to altitude in the Andes." Journal of Experimental Biology 204, no. 18 (2001): 3151–60. http://dx.doi.org/10.1242/jeb.204.18.3151.

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SUMMARYDespite the initial discomfort often experienced by visitors to high altitude, humans have occupied the Andean altiplano for more than 10000 years, and millions of people, indigenous and otherwise, currently live on these plains, high in the mountains of South America, at altitudes exceeding 3000m. While, to some extent, acclimatisation can accommodate the one-third decrease in oxygen availability, having been born and raised at altitude appears to confer a substantial advantage in high-altitude performance compared with having been born and raised at sea level. A number of characterist
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16

Luo, Yongjun, Xiaohong Yang, and Yuqi Gao. "Mitochondrial DNA response to high altitude: A new perspective on high-altitude adaptation." Mitochondrial DNA 24, no. 4 (2013): 313–19. http://dx.doi.org/10.3109/19401736.2012.760558.

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17

Litch, James A. "High Altitude: An Exploration of Human Adaptation." Wilderness & Environmental Medicine 13, no. 3 (2002): 230. http://dx.doi.org/10.1580/1080-6032(2002)013[0230:br]2.0.co;2.

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18

Otten, Edward J. "High altitude: an exploration of human adaptation." Journal of Emergency Medicine 25, no. 3 (2003): 345–46. http://dx.doi.org/10.1016/s0736-4679(03)00209-9.

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19

Moore, Lorna G. "Comparative human ventilatory adaptation to high altitude." Respiration Physiology 121, no. 2-3 (2000): 257–76. http://dx.doi.org/10.1016/s0034-5687(00)00133-x.

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20

Huey, R. B. "High Altitude: An Exploration of Human Adaptation." Integrative and Comparative Biology 42, no. 4 (2002): 910. http://dx.doi.org/10.1093/icb/42.4.910.

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21

Beall, Cynthia M. "High altitude: An exploration of human adaptation." American Journal of Human Biology 14, no. 6 (2002): 786–87. http://dx.doi.org/10.1002/ajhb.10096.

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22

Beall, Cynthia M. "Adaptation to High Altitude: Phenotypes and Genotypes." Annual Review of Anthropology 43, no. 1 (2014): 251–72. http://dx.doi.org/10.1146/annurev-anthro-102313-030000.

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23

Simonson, Tatum S., Donald A. McClain, Lynn B. Jorde, and Josef T. Prchal. "Genetic determinants of Tibetan high-altitude adaptation." Human Genetics 131, no. 4 (2011): 527–33. http://dx.doi.org/10.1007/s00439-011-1109-3.

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24

Julian, Colleen G. "Epigenomics and human adaptation to high altitude." Journal of Applied Physiology 123, no. 5 (2017): 1362–70. http://dx.doi.org/10.1152/japplphysiol.00351.2017.

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Over the past decade, major technological and analytical advancements have propelled efforts toward identifying the molecular mechanisms that govern human adaptation to high altitude. Despite remarkable progress with respect to the identification of adaptive genomic signals that are strongly associated with the “hypoxia-tolerant” physiological characteristics of high-altitude populations, many questions regarding the fundamental biological processes underlying human adaptation remain unanswered. Vital to address these enduring questions will be determining the role of epigenetic processes, or
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25

Frisancho, A. Roberto. "Developmental Functional Adaptation to High Altitude: Review." American Journal of Human Biology 25, no. 2 (2013): 151–68. http://dx.doi.org/10.1002/ajhb.22367.

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26

Horscroft, James A., Aleksandra O. Kotwica, Verena Laner, et al. "Metabolic basis to Sherpa altitude adaptation." Proceedings of the National Academy of Sciences 114, no. 24 (2017): 6382–87. http://dx.doi.org/10.1073/pnas.1700527114.

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The Himalayan Sherpas, a human population of Tibetan descent, are highly adapted to life in the hypobaric hypoxia of high altitude. Mechanisms involving enhanced tissue oxygen delivery in comparison to Lowlander populations have been postulated to play a role in such adaptation. Whether differences in tissue oxygen utilization (i.e., metabolic adaptation) underpin this adaptation is not known, however. We sought to address this issue, applying parallel molecular, biochemical, physiological, and genetic approaches to the study of Sherpas and native Lowlanders, studied before and during exposure
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27

de Aquino Lemos, Valdir, Ronaldo Vagner Thomatieli dos Santos, Fabio Santos Lira, Bruno Rodrigues, Sergio Tufik, and Marco Tulio de Mello. "Can High Altitude Influence Cytokines and Sleep?" Mediators of Inflammation 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/279365.

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The number of persons who relocate to regions of high altitude for work, pleasure, sport, or residence increases every year. It is known that the reduced supply of oxygen (O2) induced by acute or chronic increases in altitude stimulates the body to adapt to new metabolic challenges imposed by hypoxia. Sleep can suffer partial fragmentation because of the exposure to high altitudes, and these changes have been described as one of the responsible factors for the many consequences at high altitudes. We conducted a review of the literature during the period from 1987 to 2012. This work explored th
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28

Witt, Kelsey E., and Emilia Huerta-Sánchez. "Convergent evolution in human and domesticate adaptation to high-altitude environments." Philosophical Transactions of the Royal Society B: Biological Sciences 374, no. 1777 (2019): 20180235. http://dx.doi.org/10.1098/rstb.2018.0235.

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Humans and their domestic animals have lived and thrived in high-altitude environments worldwide for thousands of years. These populations have developed a number of adaptations to survive in a hypoxic environment, and several genomic studies have been conducted to identify the genes that drive these adaptations. Here, we discuss the various adaptations and genetic variants that have been identified as adaptive in human and domestic animal populations and the ways in which convergent evolution has occurred as these populations have adapted to high-altitude environments. We found that human and
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29

Castiglione, Gianni M., Frances E. Hauser, Brian S. Liao, et al. "Evolution of nonspectral rhodopsin function at high altitudes." Proceedings of the National Academy of Sciences 114, no. 28 (2017): 7385–90. http://dx.doi.org/10.1073/pnas.1705765114.

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High-altitude environments present a range of biochemical and physiological challenges for organisms through decreases in oxygen, pressure, and temperature relative to lowland habitats. Protein-level adaptations to hypoxic high-altitude conditions have been identified in multiple terrestrial endotherms; however, comparable adaptations in aquatic ectotherms, such as fishes, have not been as extensively characterized. In enzyme proteins, cold adaptation is attained through functional trade-offs between stability and activity, often mediated by substitutions outside the active site. Little is kno
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30

Zhu, Lu-lu, Zhi-jun Ma, Ming Ren, et al. "Distinct Features of Gut Microbiota in High-Altitude Tibetan and Middle-Altitude Han Hypertensive Patients." Cardiology Research and Practice 2020 (November 21, 2020): 1–15. http://dx.doi.org/10.1155/2020/1957843.

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Indigenous animals show unique gut microbiota (GM) in the Tibetan plateau. However, it is unknown whether the hypertensive indigenous people in plateau also have the distinct gut bacteria, different from those living in plains. We sequenced the V3-V4 region of the gut bacteria 16S ribosomal RNA (rRNA) gene of feces samples among hypertensive patients (HPs) and healthy individuals (HIs) from 3 distinct altitudes: Tibetans from high altitude (3600–4500 m, n = 38 and 34), Hans from middle altitude (2260 m, n = 49 and 35), and Hans from low altitude (13 m, n = 34 and 35) and then analyzed the GM c
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31

Wilsterman, Kathryn, and Zachary A. Cheviron. "Fetal growth, high altitude, and evolutionary adaptation: a new perspective." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 321, no. 3 (2021): R279—R294. http://dx.doi.org/10.1152/ajpregu.00067.2021.

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Residence at high altitude is consistently associated with low birthweight among placental mammals. This reduction in birthweight influences long-term health trajectories for both the offspring and mother. However, the physiological processes that contribute to fetal growth restriction at altitude are still poorly understood, and thus our ability to safely intervene remains limited. One approach to identify the factors that mitigate altitude-dependent fetal growth restriction is to study populations that are protected from fetal growth restriction through evolutionary adaptations (e.g., high a
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32

Holden, J. E., C. K. Stone, C. M. Clark, et al. "Enhanced cardiac metabolism of plasma glucose in high-altitude natives: adaptation against chronic hypoxia." Journal of Applied Physiology 79, no. 1 (1995): 222–28. http://dx.doi.org/10.1152/jappl.1995.79.1.222.

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The metabolism of glucose in mammalian heart is 25–50% more O2 efficient than the metabolism of free fatty acids. To assess the role of substrate preference in adaptations to chronic hypoxia, positron emission tomographic measurements of heart regional glucose uptake rates after an overnight fast were made in volunteer Quechua subjects and in Sherpa subjects, both indigenous to altitudes of over 3,000 m, and in a group of lowlander volunteers. Highest uptake rates were found in the Quechuas on arrival and in the Sherpas after a 3-wk period at low altitude, intermediate rates in Quechuas after
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33

Yang, Jian, Zi-Bing Jin, Jie Chen, et al. "Genetic signatures of high-altitude adaptation in Tibetans." Proceedings of the National Academy of Sciences 114, no. 16 (2017): 4189–94. http://dx.doi.org/10.1073/pnas.1617042114.

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Indigenous Tibetan people have lived on the Tibetan Plateau for millennia. There is a long-standing question about the genetic basis of high-altitude adaptation in Tibetans. We conduct a genome-wide study of 7.3 million genotyped and imputed SNPs of 3,008 Tibetans and 7,287 non-Tibetan individuals of Eastern Asian ancestry. Using this large dataset, we detect signals of high-altitude adaptation at nine genomic loci, of which seven are unique. The alleles under natural selection at two of these loci [methylenetetrahydrofolate reductase (MTHFR) and EPAS1] are strongly associated with blood-relat
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34

Bonnon, M., M.-C. Noël-Jorand, and P. Therme. "Criteria for Psychological Adaptation to High-Altitude Hypoxia." Perceptual and Motor Skills 89, no. 1 (1999): 3–18. http://dx.doi.org/10.2466/pms.1999.89.1.3.

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35

Storz, Jay F., and Hideaki Moriyama. "Mechanisms of Hemoglobin Adaptation to High Altitude Hypoxia." High Altitude Medicine & Biology 9, no. 2 (2008): 148–57. http://dx.doi.org/10.1089/ham.2007.1079.

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36

Cheviron, Z. A., and R. T. Brumfield. "Genomic insights into adaptation to high-altitude environments." Heredity 108, no. 4 (2011): 354–61. http://dx.doi.org/10.1038/hdy.2011.85.

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37

Ge, Ri-Li, Tatum S. Simonson, Victor Gordeuk, Josef T. Prchal, and Donald A. McClain. "Metabolic aspects of high-altitude adaptation in Tibetans." Experimental Physiology 100, no. 11 (2015): 1247–55. http://dx.doi.org/10.1113/ep085292.

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38

Ahmed, Sarah I. Y., Muntaser E. Ibrahim, and Eltahir A. G. Khalil. "High altitude and pre-eclampsia: Adaptation or protection." Medical Hypotheses 104 (July 2017): 128–32. http://dx.doi.org/10.1016/j.mehy.2017.05.007.

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39

GROVER, ROBERT F., JOHN V. WEIL, and JOHN T. REEVES. "9 Cardiovascular Adaptation to Exercise at High Altitude." Exercise and Sport Sciences Reviews 14 (1986): 269???302. http://dx.doi.org/10.1249/00003677-198600140-00012.

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40

Lorenzo, Felipe R., Chad Huff, Mikko Myllymäki, et al. "A genetic mechanism for Tibetan high-altitude adaptation." Nature Genetics 46, no. 9 (2014): 951–56. http://dx.doi.org/10.1038/ng.3067.

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41

Hull, A. D., L. D. Longo, D. M. Long, and W. J. Pearce. "Pregnancy alters cerebrovascular adaptation to high-altitude hypoxia." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 266, no. 3 (1994): R765—R772. http://dx.doi.org/10.1152/ajpregu.1994.266.3.r765.

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We have previously shown alterations in cerebrovascular composition, contractility, and endothelial function in normoxic pregnant (P) and chronically hypoxic nonpregnant (HNP) adult sheep compared with nonpregnant normoxic controls (NP). This study focuses on a fourth group, pregnant sheep exposed to chronic high-altitude hypoxia (HP) (110 days at 3,820 m). The combined challenges of pregnancy and high-altitude hypoxia resulted in significant alterations in cerebrovascular function that were not simply the summation of the responses seen in the P and HNP animals. Compared with NP, HP arteries
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42

Liu, Yang. "High-altitude adaptation in a flutter of sparrows." National Science Review 7, no. 1 (2019): 130–31. http://dx.doi.org/10.1093/nsr/nwz175.

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43

Friedrich, J., and P. Wiener. "Selection signatures for high‐altitude adaptation in ruminants." Animal Genetics 51, no. 2 (2020): 157–65. http://dx.doi.org/10.1111/age.12900.

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44

Simonson, T. S., Y. Yang, C. D. Huff, et al. "Genetic Evidence for High-Altitude Adaptation in Tibet." Science 329, no. 5987 (2010): 72–75. http://dx.doi.org/10.1126/science.1189406.

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45

Strohl, Kingman P. "Lessons in hypoxic adaptation from high-altitude populations." Sleep and Breathing 12, no. 2 (2007): 115–21. http://dx.doi.org/10.1007/s11325-007-0135-9.

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46

Wu, Dong-Dong, Cui-Ping Yang, Ming-Shan Wang, et al. "Convergent genomic signatures of high-altitude adaptation among domestic mammals." National Science Review 7, no. 6 (2019): 952–63. http://dx.doi.org/10.1093/nsr/nwz213.

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Abstract Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these
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47

Han, Xing-Tai, Ao-Yun Xie, Xi-Chao Bi, Shu-Jie Liu, and Ling-Hao Hu. "Effects of high altitude and season on fasting heat production in the yak Bos grunniens or Poephagus grunniens." British Journal of Nutrition 88, no. 2 (2002): 189–97. http://dx.doi.org/10.1079/bjn2002610.

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Thirty growing yaks Bos grunniens or Poephagus grunniens, 1·0–3·5 years and 50–230kg, from their native altitudes (3000–4000m), were used to study the basal metabolism in this species and to evaluate the effects of high altitude and season on the energy metabolism. Fasting heat production (FHP) was measured at altitudes of 2260, 3250 and 4270m on the Tibetan plateau in both the summer and the winter, after a 90d adaptation period at each experimental site. Gas exchanges of the whole animals were determined continuously for 3d (4–5 times per d, 10–12 min each time) after a 96 h starvation perio
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48

Liu, Yanjie, Huiyue Zhao, Qihua Luo, et al. "De Novo Transcriptomic and Metabolomic Analyses Reveal the Ecological Adaptation of High-Altitude Bombus pyrosoma." Insects 11, no. 9 (2020): 631. http://dx.doi.org/10.3390/insects11090631.

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Bombus pyrosoma is one of the most abundant bumblebee species in China, with a distribution range of very varied geomorphology and vegetation, which makes it an ideal pollinator species for research into high-altitude adaptation. Here, we sequenced and assembled transcriptomes of B. pyrosoma from the low-altitude North China Plain and the high-altitude Tibet Plateau. Subsequent comparative analysis of de novo transcriptomes from the high- and low-altitude groups identified 675 common upregulated genes (DEGs) in the high-altitude B. pyrosoma. These genes were enriched in metabolic pathways and
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49

Zhou, Q. "P224Relationship between high altitude de-adaptation and acute high altitude response, cardiac function injury after returning to lower altitude population exposure to high altitude environment." Cardiovascular Research 103, suppl 1 (2014): S40.1—S40. http://dx.doi.org/10.1093/cvr/cvu082.157.

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50

Keenan, Daniel M., Jacqueline Pichler Hefti, Johannes D. Veldhuis, and Michael Von Wolff. "Regulation and adaptation of endocrine axes at high altitude." American Journal of Physiology-Endocrinology and Metabolism 318, no. 2 (2020): E297—E309. http://dx.doi.org/10.1152/ajpendo.00243.2019.

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As a model of extreme conditions, eight healthy women, part of a 40-member Nepal mountain-climbing expedition, were monitored for dynamic endocrine adaptations. Endocrine measurements were made at frequent intervals over a 6–10-h period at four altitudes: 450 m, 4,800 m (base camp), 6,050 m, and again at 4,800 m (on descent) after an acclimatization (A) period (4,800 mA). Quantified hormones were growth hormone (GH), prolactin (PROL), cortisol (Cort), thyroid-stimulating hormone (TSH), and free thyroxine. These hormones are important to the anabolic/catabolic balance of the body, and are vital
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