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Relevant bibliographies by topics / High malignancy / Dissertations / Theses

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Dissertations / Theses on the topic 'High malignancy'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Enyakoit, G. O. "Cytogenetic analysis of DNA copy number aberrations in high malignancy grade astrocytomas." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444158/.

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Astrocytomas are the most common variety of primary tumours of the central nervous system (CNS). The incidence increases with age, peaking in patients aged 65--75 years. They are generally unresponsive to treatment, and most patients die within one year of diagnosis. Recent genetic studies of astrocytoma susceptibility syndromes, familial- and sporadic astrocytomas have led to the discovery of many genes and molecular mechanisms underlying astrocytoma oncogenesis. A few of the genes involved in inherited astrocytoma associated-syndromes (e.g., Cowden and Li-Fraumeni syndromes) are also strongl

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2

Enyakoit, George Ojula. "A genome-wide investigatin of DNA copy number aberrations in high malignancy grade astrocytomas." Thesis, University College London (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500063.

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3

Brown, I. "High linear energy transfer endoradiotherapeutic drugs for malignant disease." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596984.

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4

Jackson, L. A. "Cytogenetic and molecular genetic analysis of normal, pre-malignant and malignant breast tissue from patients in high-risk families." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604988.

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The data presented in this thesis demonstrates that 60.0% of the morphologically normal samples from women at high risk for breast cancer showed genomic copy number aberrations by CGH. There was an average of 1.45 aberrations per sample analysed. These aberrations seemed to be spread throughout the genome, however, there were some regions of interest. These were gains on 1p, 9p, 16p 16q and 19. The presence of these aberrations suggests that morphologically normal epithelial cells analysed from these cases have a degree of genomic instability. The CGH results for HUT presented a complicated pr

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Arlotta, Paola. "The high mobility group protein I-C : transcriptional regulation and involvement in the formation of lipomas in transgenic mice." Thesis, University of Portsmouth, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311184.

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6

Garcia, Paulo A. "Irreversible Electroporation for the Treatment of Aggressive High-Grade Glioma." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/77269.

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Malignant gliomas (MG), most notably glioblastoma multiforme (GBM), are among the most aggressive of all malignancies. High-grade variants of this type of brain cancer are generally considered incurable with singular or multimodal therapies. Many patients with GBM die within one year of diagnosis, and the 5-year survival rate in people is approximately 10%. Despite extensive research in diagnostic and therapeutic technologies, very few developments have emerged that significantly improve survival over the last seven decades. Irreversible electroporation (IRE) is a new non-thermal focal tissue

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7

Chikada, Ai. "A descriptive analysis of end-of-life discussions for high-grade glioma patients." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/264666.

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京都大学<br>新制・課程博士<br>博士(人間健康科学)<br>甲第23385号<br>人健博第92号<br>新制||人健||6(附属図書館)<br>京都大学大学院医学研究科人間健康科学系専攻<br>(主査)教授田村恵子, 教授稲富宏之, 教授溝脇尚志<br>学位規則第4条第1項該当<br>Doctor of Human Health Sciences<br>Kyoto University<br>DFAM

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8

Ivey, Jill Winters. "Investigating the Applications of Electroporation Therapy for Targeted Treatment of Glioblastoma Multiforme Based on Malignant Properties of Cells." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/78806.

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Glioblastoma multiforme (GBM) is the most common and lethal primary brain cancer with an average survival time of 15 months. GBM is considered incurable with even the most aggressive multimodal therapies and is characterized by near universal recurrence. Irreversible electroporation (IRE) is a cellular ablation method currently being investigated as a therapy for a variety of cancers. Application of IRE involves insertion of electrodes into tissue to deliver pulsed electric fields (PEFs), which destabilize the cell membrane past the point of recovery, thereby inducing cell death. While this tr

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9

Callanan, Mary. "Caractérisation moléculaire d'une t(1;22)(q21;q11) impliquée dans la progression tumorale dans les lymphomes malins non Hodgkiniens." Université Joseph Fourier (Grenoble ; 1971-2015), 1997. http://www.theses.fr/1997GRE10177.

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Les rearrangements du bras long du chromosome 1 sont parmi les plus frequemment observes dans les tumeurs humaines. La plupart de ces rearrangements impliquent la bande chromosomique 1q21. Ce sont soit des translocations desequilibrees soit moins frequemment des translocations equilibrees avec de nombreux chromosomes partenaires. Ces anomalies surviennent plutot au cours de l'evolution d'une tumeur et seraient donc impliquees dans la progression tumorale. Cependant elles ont aussi ete observees dans des etats preneoplasiques precedant de plusieurs mois, voire annees, l'eclosion de la tumeur ma

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10

Nkosana-Nyawata, Idah D. "Understanding delay : a grounded theory examination of the pre-diagnostic journey of individuals with malignant melanoma. An analysis of the experiences of individuals subsequently diagnosed with high risk malignant melanoma from problem identification through to initial specialist treatment." Thesis, University of Bradford, 2008. http://hdl.handle.net/10454/4314.

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11

Nkosana-Nyawata, Idah Dzanisa. "Understanding delay : a grounded theory examination of the pre-diagnostic journey of individuals with malignant melanoma : an analysis of the experiences of individuals subsequently diagnosed with high risk malignant melanoma from problem identification through to initial specialist treatment." Thesis, University of Bradford, 2008. http://hdl.handle.net/10454/4314.

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12

Hussenet, Thomas. "Toward the identification of oncogenes by high resolution mapping of gene amplifications of the 3q25-qter region in malignant fibrous histiocytoma and squamous cell carcinoma." Strasbourg 1, 2005. https://publication-theses.unistra.fr/public/theses_doctorat/2005/HUSSENET_Thomas_2005.pdf.

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L’approche de clonage positionnel a été appliquée à la cartographie haute résolution des aberrations du chromosome 3 dans différents types tumoraux afin d’identifier de nouveaux candidats oncogènes du bras long du chromosome 3 (3q), amplifiés et sur-exprimés en conséquence. Une première partie a été dédiée aux Fibro-Histiocytomes Malins (MFH). Des amplicons chevauchants du locus 3q28 ont été caractérisés dans une lignée cellulaire et deux tumeurs de MFH. A ce locus, nous avons identifié un oncogène candidat, hsa-miR-28, codant pour un microARN ainsi que trois de ses cibles, impliquées dans la

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13

Leventoux, Nicolas. "Etude des foyers d’hétérogénéité tumorale dans les gliomes diffus de bas grade de l’adulte mutés IDH1." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT037.

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Les gliomes sont les principales tumeurs primitives du cerveau affectant environ 4000 nouveaux patients par an en France. La moitié des gliomes est détectée au stade avancé de glioblastome (grade IV) tandis que 15% des tumeurs sont diagnostiquées au stade II de gliomes diffus dit de bas grade. Ces tumeurs affectent des patients jeunes et présentent des mutations caractéristiques, notamment une mutation pour l’enzyme IDH1 communément retrouvée dans les glioblastomes secondaires. Ces tumeurs de bas grade sont traitées par une chirurgie, idéalement en condition éveillée mais du fait de leur natur

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14

Ciappuccini, Renaud. "Apport de l'imagerie fonctionnelle par TEMP/TDM et TEP/TDM dans la prise en charge des cancers différenciés de la thyroïde Incremental Value of a Dedicated Head and Neck Acquisition during 18F-FDG PET/CT in Patients with Differentiated Thyroid Cancer Full text links full-text provider logo Actions Favorites Share Page navigation Title & authors Abstract Conflict of interest statement Figures Similar articles Cited by References Related information LinkOut - more resources EJNMMI Res . 2018 Dec 3;8(1):104. doi: 10.1186/s13550-018-0461-x. Optimization of a dedicated protocol using a small-voxel PSF reconstruction for head-and-neck 18 FDG PET/CT imaging in differentiated thyroid cancer 78 Lymph node involvement in head-and-neck and thyroid cancers with digital PET/CT: the impact of ultra-high definition voxels and point-spread function Tumor burden of persistent disease in patients with differentiated thyroid cancer: correlation with postoperative risk-stratification and impact on outcome 133 18F-Fluorocholine PET/CT is a highly sensitive but poorly specific tool for identifying malignancy in thyroid nodules with indeterminate cytology: The Chocolate study PSMA expression in neovasculature of persistent/recurrent differentiated thyroid cancerin the neck: relationship with radioiodine uptake, 18Fluorodeoxyglucose avidity and outcome." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC424.

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L’imagerie scintigraphique des cancers thyroïdiens différenciés (CTD) présente la particularité d’utiliser deux radiopharmaceutiques, l’iode 131 (131I) et le 18-Fluorodésoxyglucose (18FDG). La fixation de ces traceurs dépend habituellement du degré de différenciation et de l’agressivité de la tumeur. L’objectif de ce travail était d’étudier l’apport de différents aspects techniques et d’instrumentation, à savoir l’imagerie hybride par TEMP/TDM et TEP/TDM, la point-spread function (PSF), la taille des voxels et la technologie TEP digitale, et d’explorer si d’autres traceurs TEP pouvaient présen

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15

Su, Yu-Chieh, and 蘇裕傑. "High Dose Chemotherapy followed by Autologous Peripheral Stem Cell Transplantation in Patients with Metastatic Cancer and Hematological Malignancy — A Single Institute’s Experience and Result Analysis." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/03748394885187779628.

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碩士<br>高雄醫學大學<br>醫學研究所<br>91<br>There has been a dramatic increase in the number of autologous peripheral blood stem cell transplants (PBSCT) over the last decade. Faster recovery of cell counts, lesser transplant morbidity, shorter hospital stay and reduced cost compared with marrow autografts have been the main advantages. Numerous clinical trials demonstrated improved outcome using HDCT with autologous PBSCT in non-Hodgkin’s lymphoma (NHL). But there are few reports evaluating the role of HDCT with autologous PBSCT in metastatic nasopharyngeal carcinoma (NPC). Here we report our experience i

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16

Chang, Shao-En, and 張韶恩. "AAD01 reduces tumor hypoxia by increasing tissue perfusion in high grade malignant gliomas." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/04381384016067650565.

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碩士<br>國立陽明大學<br>腦科學研究所<br>98<br>Background: Intra-tumoral hypoxia is associated with malignant progression, tumor invasion and resistance to radiotherapy and chemotherapy of cancers. Anti-angiogenic therapies targeting the vascular endothelial growth factor (VEGF) / VEGF receptor (V EGFR) have shown therapeutic effect for malignant tumors. However, they also increase intra-tumoral hypoxia. Anti-angiogenic drug 01 (AAD01), on the other hand, targets endothelial cells directly. Tetramethylpyrazine (TMP) decreased the expression of VEGF and reduced angiogenesis. This study would test these two dr

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17

Chen, Li-chiu, and 陳麗秋. "Identification of serum tumor markers for malignant disease using high-throughput proteomic technologies." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/73930771765341250337.

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碩士<br>長庚大學<br>醫學生物技術研究所<br>92<br>Background: Malignant tumors are at the top leading cause of death in Taiwan in the past decades. Currently, there is no serum marker for detecting oral or nasopharyngeal cancers (ORC or NPC), neither available serum marker with high sensitivity and specificity for breast, lung, and prostate cancers (BC, LC, and PC). Methods: Affinity purification with magnet beads and MALDI-TOF mass spectrometry analysis were used to screen and identify potential serum tumor markers for BC, LC, PC, ORC, and NPC. Compiled protein profile of each cancer group was comp

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18

Hung, Tsui Lien, and 洪翠蓮. "The underlying mechanisms of high invasiveness in tumor cells from lung cancer patients with malignant pleural effusion." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/52852434576744912387.

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碩士<br>國立成功大學<br>分子醫學研究所<br>89<br>Non-small cell lung cancer (NSCLC) associated with malignant pleural effusion (MPE) is a common presentation of lung cancer in Taiwan. The major histological classification of this entity is adenocarcinoma. Microscopically, the patients’ pleurae were infiltrated by numerous tumor foci, which suggests that the adenocarcinoma cells are highly invasive. Among the NSCLC, lung adenocarcinom also has the highest incidence of distant metastasis. Because the malignant pleural effusion is closely related to lung adenocarcinoma and it is easily obtained, we tried to ana

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19

Chen, Shao-Ching, and 陳少卿. "Risk Factors Associated with the Progression of Pre-malignant Oral Lesion and Oral Cancer: A Screening Project in High-risk Group." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/00620268438093399814.

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碩士<br>國立臺灣大學<br>流行病學研究所<br>89<br>Background: The impacts of the duration and the quantity of betel nuts, cigarettes, and alcohol on the disease natural history of oral pre-malignancy and economic aspect of oral cancer screening in betel nuts user have not been fully addressed. Objectives: The purposes of this study are therefore (1) to quantify the impact of the duration and the quantity of betel nut, cigarette and alcohol on different oral pre-malignancy and transition parameters between states with respect to the disease natural history; and (2) to perform cost-effectiveness analy

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20

CHEN, YI-WEN, and 陳怡文. "High Folic Acid Supplementation Reprograms The Bioenergetics Mechanism of Lactate Metabolic Microenvironment to Promote The Malignant Progression in Non-small Cell Lung Cancer." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/4t8vj9.

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碩士<br>輔仁大學<br>營養科學系碩士班<br>107<br>Lung cancer is the leading cause of cancer deaths in Taiwan, and of which 85% is non-small cell lung cancer (NSCLC). The five-year survival rate of lung cancer patients with metastasis is less than 10%. Studies showed that the poor prognosis of lung cancer patients was mainly due to highly invasion and metastasis. It was known that malignant tumors were viewed as cancer stem cell (CSC) metabolic variability diseases, and CSCs were involved in regulating epithelial-mesenchymal transition (EMT), invasion, metastasis, and chemotherapy resistance. Tumor cells under

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