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Journal articles on the topic 'High malignancy'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Alvegård, T. A., and N. O. Berg. "Histopathology peer review of high-grade soft tissue sarcoma: the Scandinavian Sarcoma Group experience." Journal of Clinical Oncology 7, no. 12 (1989): 1845–51. http://dx.doi.org/10.1200/jco.1989.7.12.1845.

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From 1981 to 1986, a total of 240 patients with a primary soft tissue sarcoma with malignancy grade III or IV were entered into an adjuvant chemotherapy multicenter trial conducted by the Scandinavian Sarcoma Group (SSG). Histopathologic peer review of all the specimens was performed by an expert pathology committee. The most common soft tissue sarcoma after review was malignant fibrous histiocytoma (MFH) (40%), followed by synovial sarcoma (15%), leiomyosarcoma (9%), liposarcoma (8%), and malignant Schwannoma (6%). In 25% of the cases the histologic type of sarcoma was reclassified, and in 40

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Liang, Yuanxin, Robert S. Heller, Julian K. Wu, Carl B. Heilman, Arthur S. Tischler, and Knarik Arkun. "High p16 Expression Is Associated with Malignancy and Shorter Disease-Free Survival Time in Solitary Fibrous Tumor/Hemangiopericytoma." Journal of Neurological Surgery Part B: Skull Base 80, no. 03 (2018): 232–38. http://dx.doi.org/10.1055/s-0038-1669419.

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Objective Solitary fibrous tumors (SFT) and hemangiopericytomas (HPC) are now classified along a single spectrum of fibroblastic mesenchymal tumors with NAB2–STAT6 fusion. This fusion acts as a driver mutation that constitutively activates EGR1, which is known to be involved in the p16 pathway. Overexpression of p16 is associated with malignancy and worse prognosis in multiple mesenchymal tumors. The authors sought to investigate p16 immunoexpression in association with malignancy and prognosis of SFT/HPC tumors. Design Twenty-three SFT/HPC tumors (central nervous system [CNS]: 12, non CNS: 11

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Paul, Prasad, Karatparambil Abid Ali, and Mohammed Jasir. "Predictors of malignancy in solitary nodule thyroid." International Surgery Journal 4, no. 2 (2017): 703. http://dx.doi.org/10.18203/2349-2902.isj20170217.

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Background: Solitary nodule thyroid is one of the common surgical problems and incidence of malignancy is also high compared to multinodular goiter. If you can avoid aggressive surgery in benign cases, we can reduce the occurrence of complications. So it’s important to look for the malignant predictors. The aim of the study was to evaluate the malignant predictors in solitary nodule thyroid.Methods: Total of 80 patients with solitary thyroid nodule were included in prospective study. The study was done from January 2015 to January 2016.Results: Most of the malignant cases are occurring in fema

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Black, Keith L., Randall A. Hawkins, Kenneth T. Kim, Donald P. Becker, Carole Lerner, and Donna Marciano. "Use of thallium-201 SPECT to quantitate malignancy grade of gliomas." Journal of Neurosurgery 71, no. 3 (1989): 342–46. http://dx.doi.org/10.3171/jns.1989.71.3.0342.

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✓ A quantitative preoperative technique using thallium-201 single-photon emission computerized tomography is described which predicts whether specific gliomas are of high- or low-grade malignancy. An index, based on the ratio of thallium uptake in the tumor versus the homologous contralateral brain, was calculated and compared with tumor histology. The index in 14 patients with low-grade malignant gliomas was 1.27 ± 0.40 in contrast to an index of 2.40 ± 0.61 in 11 patients with high-grade malignant gliomas (p < 0.0005). Whether gliomas were of low- or high-grade malignancy could be predict

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Bhardwaj, Rajeev, and Rishabh Kumar Rana. "Exploring the Diagnostic Efficacy of Fine-Needle Aspiration Cytology in Thyroid Nodules ≥ 4 cm: Results from a Tertiary Health Care Center in Jharkhand." International Journal of Recent Surgical and Medical Sciences 4, no. 02 (2018): 054–56. http://dx.doi.org/10.1055/s-0038-1676561.

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Abstract Background Any nodules of the thyroid, ≥ 4 cm, are generally associated with false-negative results for malignancy on fine-needle aspiration cytology (FNAC), which generally are confirmed cases of malignancy after histopathologic examinations. Methods A retrospective hospital-based study was done in which data of patients having thyroid lesions ≥ 4 cm were reviewed. We checked the FNAC and histopathologic examination done on these lesions. Ultrasonography (USG)–guided aspiration records were also assessed. Sensitivity and specificity of FNAC for the detection of neoplastic or malignan

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Mahalingappa, Y. B., and H. S. Khalil. "Sinonasal malignancy: presentation and outcomes." Journal of Laryngology & Otology 128, no. 7 (2014): 654–57. http://dx.doi.org/10.1017/s0022215114001066.

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AbstractObjective:We wanted to identify the presentation, diagnostic work-up and treatment outcomes of patients with sinonasal malignancy at Derriford Hospital, Plymouth, UK and compare these with the European Position Paper on Endoscopic Management of Tumours of the Nose, Paranasal Sinuses and Skull Base.Materials and methods:This was a retrospective audit of all patients diagnosed with sinonasal malignancy over a five-year period. The clinical records and picture archiving and communications system data of the patients were reviewed.Results:Thirty patients with sinonasal malignancy were iden

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Rorive, Sandrine, Nicky D'Haene, Caroline Fossion, et al. "Ultrasound-guided fine-needle aspiration of thyroid nodules: stratification of malignancy risk using follicular proliferation grading, clinical and ultrasonographic features." European Journal of Endocrinology 162, no. 6 (2010): 1107–15. http://dx.doi.org/10.1530/eje-09-1103.

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ObjectiveTo evaluate the diagnostic value of fine-needle aspiration (FNA) cytology and the additive contribution brought by clinical and ultrasound (US) features.MethodCytological and histological diagnoses were compared in a series of 924 patients who underwent US-guided FNA before surgery. We additionally developed a grading system for follicular proliferation (FP) FNA diagnosis, and investigated its impact on the malignancy risk as well as the additive contribution of clinical and US features by means of decision tree analysis.ResultsExcluding FP cases (n=395), our data demonstrated that st

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Rai, Rojna, Pema Choden Bhutia, and Ugyen Tshomo. "Clinicopathological profile of adnexal masses presenting to a tertiary-care hospital in Bhutan." South Asian Journal of Cancer 08, no. 03 (2019): 168–72. http://dx.doi.org/10.4103/sajc.sajc_303_18.

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Abstract Context: Adnexal masses of ovarian origin are of growing concern due to high fatality associated with ovarian malignancy because they are diagnosed at advanced stage due to vague symptoms and absence of recommended screening tests. Aims: The aim was to study the prevalence of histopathologic types of adnexal masses in different age groups and to analyze the accuracy of preoperative evaluation in diagnosing ovarian malignancy. Settings and Design: This was a cross-sectional study carried out in the Department of Obstetrics and Gynecology of a tertiary care hospital in Bhutan with gynec

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Hui, Kathleen K., John G. Batsakis, Mario A. Luna, Bruce MacKay, and Robert M. Byers. "Salivary duct adenocarcinoma: a high grade malignancy." Journal of Laryngology & Otology 100, no. 1 (1986): 105–14. http://dx.doi.org/10.1017/s0022215100098807.

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AbstractSalivary duct carcinomas of the major salivary glands have two major distinguishing features. They closely resemble ductal carcinomas of the breast and they are high-grade malignancies. In general, but particularly for carcinomas measuring three or more centimeters in size, the clinical course is one characterized by a resistance to local control, metastases to regional lymph nodes and distant sites, and death within a few years after primary surgical treatment.

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10

Lucas, Fletcher, Adsay, and Zalupski. "High-grade extraskeletal myxoid chondrosarcoma: a high-grade epithelioid malignancy." Histopathology 35, no. 3 (1999): 201–8. http://dx.doi.org/10.1046/j.1365-2559.1999.00735.x.

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Hakala, T., I. Kholová, J. Sand, R. Saaristo, and P. Kellokumpu-Lehtinen. "A core needle biopsy provides more malignancy-specific results than fine-needle aspiration biopsy in thyroid nodules suspicious for malignancy." Journal of Clinical Pathology 66, no. 12 (2013): 1046–50. http://dx.doi.org/10.1136/jclinpath-2013-201559.

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Background and aimsThe most commonly used diagnostic method for the preoperative diagnosis of thyroid nodules is ultrasound-guided fine-needle aspiration biopsy (FNA), which often yields non-diagnostic or non-definitive results and seldom produces definite malignant diagnoses. To improve upon the malignancy-specific sensitivity, we tested core needle biopsies (CNBs) of thyroid lesions taken from surgical specimens.Material and methods52 consecutive patients with malignant or malignant-suspicious thyroid nodules were referred to Tampere University Hospital between May 2010 and December 2011. Pr

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Zhu, Jianwei, Jianhua Zou, Zhanjie Zhang, et al. "An NIR triphenylamine grafted BODIPY derivative with high photothermal conversion efficiency and singlet oxygen generation for imaging guided phototherapy." Materials Chemistry Frontiers 3, no. 8 (2019): 1523–31. http://dx.doi.org/10.1039/c9qm00044e.

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Osteosarcoma, the most common malignant bone tissue tumor, with a high degree of malignancy, strong metastasis, and early lung metastasis, can result in extremely high mortality, and is a serious threat to human health.

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Hjorth, Lisbet, Hans Dommerby, Steen Kruse, and Annemarie Nielsen. "Primary Malignant Lymphoma of the Salivary Glands." Tumori Journal 72, no. 5 (1986): 491–97. http://dx.doi.org/10.1177/030089168607200507.

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Five cases of primary malignant lymphomas of the salivary glands are reported. Four lymphomas arose in the parotid gland and one in the submandibular gland. All were non-Hodgkin lymphomas. In 4 cases the lymphomas were of low-grade malignancy, viz. 2 immunocytomas and 2 centroblastic/centrocytic malignant lymphomas, and 1 was a T-immunoblastic malignant lymphoma of high-grade malignancy. Four patients with localized disease were treated with radiotherapy and 1 patient with disseminated disease was treated with chemotherapy. One patient died from a disease unrelated to the malignant lymphoma, a

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Möröy, T., P. E. Fisher, G. Lee, P. Achacoso, F. Wiener, and F. W. Alt. "High frequency of myelomonocytic tumors in aging E mu L-myc transgenic mice." Journal of Experimental Medicine 175, no. 2 (1992): 313–22. http://dx.doi.org/10.1084/jem.175.2.313.

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Transgenic mice that contain constructs of the L-myc gene under the transcriptional control of the immunoglobulin heavy chain enhancer (E mu) develop thymic hyperplasia and are predisposed to T cell lymphomas. Here we describe a second form of malignancy that occurs in aging E mu L-myc transgenic mice. The mean latency period for the development of this malignancy is longer compared with the E mu L-myc T cell lymphomas but the overall incidence is increased threefold. The histopathological morphology is that of a highly malignant mesenchymal neoplasm that closely resembles human fibrous histio

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Wong, Michael, Nikolaos Thanatsis, Federica Nardelli, Tejal Amin, and Davor Jurkovic. "Risk of Pre-Malignancy or Malignancy in Postmenopausal Endometrial Polyps: A CHAID Decision Tree Analysis." Diagnostics 11, no. 6 (2021): 1094. http://dx.doi.org/10.3390/diagnostics11061094.

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Background and aims: Postmenopausal endometrial polyps are commonly managed by surgical resection; however, expectant management may be considered for some women due to the presence of medical co-morbidities, failed hysteroscopies or patient’s preference. This study aimed to identify patient characteristics and ultrasound morphological features of polyps that could aid in the prediction of underlying pre-malignancy or malignancy in postmenopausal polyps. Methods: Women with consecutive postmenopausal polyps diagnosed on ultrasound and removed surgically were recruited between October 2015 to O

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Sharma, Pooja, Prashant Ramteke, Abhishek Satapathy, and MD Ray. "Xanthogranulomatous Orchitis Presenting as a Scrotal Mass in an Elderly Male: Malignancy or Mimicker?" Clinical Medicine Insights: Case Reports 12 (January 2019): 117954761989029. http://dx.doi.org/10.1177/1179547619890295.

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Xanthogranulomatous inflammation is a rare, destructive pattern of inflammation, affecting different organs, that often produces a mass-like lesion, simulating malignancy. Although benign, it can coexist with malignancy. We, herein, report the case of a 60-year-old male patient, who presented with a testicular mass that was partly necrotic and showed heterogeneous enhancement on contrast study. Testicular tumor markers were normal. In view of clinicoradiological suspicion of a malignant cause, high inguinal orchidectomy was performed. However, histopathology showed features of a xanthogranulom

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Bent, Talitha, Derya Yakar, and Thomas C. Kwee. "Clinical and FDG-PET/CT Suspicion of Malignant Disease: Is Biopsy Confirmation Still Necessary?" Diagnostics 11, no. 3 (2021): 559. http://dx.doi.org/10.3390/diagnostics11030559.

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Background: Biopsy of 18F-fluoro-2-deoxy-D-glucose (FDG)-avid lesions suspected for malignancy remains an invasive procedure associated with a variety of risks. It is still unclear if the positive predictive value (PPV) of positron emission tomography (PET)/computed tomography (CT) is sufficiently high to avoid tissue sampling. Therefore, the purpose of this study was to determine the PPV of 18F-FDG-PET/CT for malignancy in patients with a clinical suspicion of active malignant disease. Methods: This single-center retrospective study included 83 patients who had undergone FDG-PET/CT within 60

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Crespo, Manuel, Bernardo Sopeña, John J. Orloff, et al. "Immunohistochemical Detection of Parathyroid Hormone–Related Protein in a Cutaneous Squamous Cell Carcinoma Causing Humoral Hypercalcemia of Malignancy." Archives of Pathology & Laboratory Medicine 123, no. 8 (1999): 725–30. http://dx.doi.org/10.5858/1999-123-0725-idophr.

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Abstract Humoral hypercalcemia of malignancy is a cancer-related hypercalcemia caused by production of humoral factors by malignant cells in patients without bone metastases. Squamous cell carcinomas are the tumors most frequently associated with humoral hypercalcemia of malignancy, and parathyroid hormone–related protein is the main humoral factor implicated. In spite of the fact that normal keratinocytes produce parathyroid hormone–related protein, it is highly unusual for patients with squamous cell carcinomas of the skin to present with humoral hypercalcemia of malignancy. We present a wel

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Milos, Ruxandra Iulia, Francesca Pipan, Anastasia Kalovidouri, et al. "The Kaiser score reliably excludes malignancy in benign contrast-enhancing lesions classified as BI-RADS 4 on breast MRI high-risk screening exams." European Radiology 30, no. 11 (2020): 6052–61. http://dx.doi.org/10.1007/s00330-020-06945-z.

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Abstract Objectives MRI is an integral part of breast cancer screening in high-risk patients. We investigated whether the application of the Kaiser score, a clinical decision-support tool, may be used to exclude malignancy in contrast-enhancing lesions classified as BI-RADS 4 on breast MRI screening exams. Methods This retrospective study included 183 consecutive, histologically proven, suspicious (MR BI-RADS 4) lesions detected within our local high-risk screening program. All lesions were evaluated according to the Kaiser score for breast MRI by three readers blinded to the final histopathol

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Gunay, Yusuf, Ebru Demiralay, and Alp Demirag. "Pancreatic Metastasis of High-Grade Papillary Serous Ovarian Carcinoma Mimicking Primary Pancreas Cancer: A Case Report." Case Reports in Medicine 2012 (2012): 1–3. http://dx.doi.org/10.1155/2012/943280.

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Introduction. Reports of epithelial ovarian carcinomas metastatic to the pancreas are very rare. We herein present a metastasis of high grade papillary serous ovarian cancer to mid portion of pancreas.Case. A 42-year-old patient was admitted with a non-specified malignant cystic lesion in midportion of pancreas. She had a history of surgical treatment for papillary serous ovarian adenocarcinoma. A cystic lesion was revealed by an abdominal computerized tomography (CT) performed in her follow up . It was considered as primary mid portion of pancreatic cancer and a distal pancreatectomy was perf

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Musawwir, Raihana, Sheuly Akhter, and Fatema Begum. "High CA-125 in Endometrioma: An Unusual Presentation." KYAMC Journal 9, no. 3 (2018): 139–40. http://dx.doi.org/10.3329/kyamcj.v9i3.38788.

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CA-125 (cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) also known as mucin 16 or MUC16 is a protein of mucin family glycoprotein that is encoded by the MUC16 gene. It is the most frequently used biomarker for ovarian cancer. It may also be elevated in other cancers, including endometrium, fallopian tube, lung, breast and gastrointestinal cancer and in a number of relatively benign conditions, such as endometriosis, menstruation and pregnancy. High plasma levels of more than 200 U/mL are usually suggestive of malignancy but rarely found in benign conditions of female ge

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Munitiz, Vicente, Pascual Parrilla, Angeles Ortiz, Luisa F. Martinez-de-Haro, Jose Yelamos та Joaquin Molina. "High Risk of Malignancy in Familial Barrettʼs Esophagus". Journal of Clinical Gastroenterology 42, № 7 (2008): 806–9. http://dx.doi.org/10.1097/mcg.0b013e3180329015.

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NAPOLI, DENISE. "Risk High for Second Primary Malignancy After Melanoma." Skin & Allergy News 41, no. 6 (2010): 5. http://dx.doi.org/10.1016/s0037-6337(10)70151-0.

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Inoue, K. i. "Is the Discordance Rate of Malignancy Still High?" Archives of Internal Medicine 159, no. 9 (1999): 1013. http://dx.doi.org/10.1001/archinte.159.9.1013.

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Nahar, Begum Afrin, Rama Saha, Chhanda Das, and Gourishankar Kamilya. "Immunohistochemical expression of human epididymis 4 in ovarian malignancy." International Journal of Research in Medical Sciences 7, no. 12 (2019): 4493. http://dx.doi.org/10.18203/2320-6012.ijrms20195506.

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Background: Ovarian malignancies has the highest mortality rate among all gynaecological malignancies. Surface epithelial tumors form two thirds of all ovarian neoplasm and 90% of all ovarian cancers are surface epithelial carcinomas. Mortality in case of ovarian malignancy is high due to late diagnosis. Early and accurate diagnosis can improve the case specific management. HE4 (Human Epididymis Protein 4) which is proved to be overexpressed in the ovarian cancer cells, is considered a new biomarker for ovarian cancer diagnosis which helps in early diagnosis and patient management. Aims and ob

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Alcázar, Juan Luis, Laura Pineda, and Jesús Utrilla-Layna. "Predicting Malignancy in Entirely Solid-appearing Adnexal Masses on Gray-Scale Ultrasound Based on Additional Ultrasound Findings, Clinical Complaints and Biochemical Parameters: A Retrospective Study." Donald School Journal of Ultrasound in Obstetrics and Gynecology 7, no. 1 (2013): 80–85. http://dx.doi.org/10.5005/jp-journals-10009-1273.

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ABSTRACT Purpose To determine which clinical, biochemical and other sonographic parameters could be useful to predict malignancy in sonographically solid adnexal masses. Materials and methods Clinical, biochemical and other sonographic features from 227 women diagnosed as having an entirely solid adnexal mass on B-mode gray-scale ultrasound were reviewed for this retrospective study. All patients had undergone surgery and mass removal. Definitive histologic diagnosis was available in all cases. All parameters were compared to final histological diagnosis (benign or malignant) in univariate sta

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Alcázar, Juan Luis, Pedro Royo, Rosendo Galván, et al. "Assessment of an Ultrasound-based Scoring System for Triaging Ovarian Tumors in Symptomatic Women." Donald School Journal of Ultrasound in Obstetrics and Gynecology 3, no. 1 (2009): 9–14. http://dx.doi.org/10.5005/jp-journals-10009-1003.

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Abstract Objective To evaluate prospectively an ultrasound-based scoring system as a method for triaging symptomatic women presenting with an adnexal mass for surgical treatment. Methods 151 symptomatic women scheduled for surgical treatment at our institution were included in this prospective study. Patients were evaluated by transvaginal power Doppler ultrasound prior to surgery. Patients were classified as low-risk or high-risk for malignancy according an ultrasound-based scoring system. Patients with low risk for malignancy were scheduled for laparoscopy and patients for high risk for mali

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Bansal, Dhananjay, Anubhav Gupta, Sameek Bhattacharya, Sudesh Kumar, Vijay Kumar Gupta, and Palash Aiyer. "Recurrent high-grade chondrosarcoma abutting the right ventricular outflow tract." Asian Cardiovascular and Thoracic Annals 27, no. 6 (2019): 501–4. http://dx.doi.org/10.1177/0218492319840967.

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Chondrosarcoma is the most common malignancy of the sternum. Removal of the sternum for a malignant tumor results in large defects in bone and soft tissue, causing deformity and paradoxical chest wall movement, making subsequent repair of the thorax very important. Herein we report a rare case of recurrent anterior chest wall chondrosarcoma after surgery 4 years earlier. The patient underwent resection of the chondrosarcoma followed by three-layer chest wall reconstruction with a split rib graft for the bony defect. He had an uneventful postoperative course and was healthy at 9 months postoper

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TARRAR, AIMEL MUNIR, MADIHA SAEED WAHLA, SOHAIL ILYAS, Obaid Ullah Khan, Ahmed Waqas, and Ahmed Raza. "SOLITARY THYROID NODULE." Professional Medical Journal 17, no. 04 (2010): 598–602. http://dx.doi.org/10.29309/tpmj/2010.17.04.2978.

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Objectives: To determine frequency of malignancy in solitary thyroid nodule. Design: Case-series study. Place and Duration of Study: The study was conducted at Department of Surgery, Combined Military Hospital Rawalpindi, from April 2002 till April 2003. Patients and Methods: Sixty patients with clinical solitary thyroid nodule fulfilled the selection criteria and were included in the study. Thyroid function tests, ultrasonography and thyroid scanning was done. Finally FNAC and histopathology were done in all the operated cases and record was evaluated. Results: Out of 60 cases studied, 8 (13.

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Kakudo, Kennichi, Kaori Kameyama, Mitsuyoshi Hirokawa, Ryohei Katoh, and Hirotoshi Nakamura. "Subclassification of Follicular Neoplasms Recommended by the Japan Thyroid Association Reporting System of Thyroid Cytology." International Journal of Endocrinology 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/938305.

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Background. The Japan Thyroid Association recently published guidelines for clinical practice for the management of thyroid nodules, which include a diagnostic system for reporting thyroid fine needle aspiration cytology. It is characterized by the subclassification of follicular neoplasms, which is different from other internationally accepted reporting systems.Materials and Methods. This study examined observer variability in the subclassification of follicular neoplasms among 4 reviewers using Papanicolaou-stained smear samples from 20 surgically treated patients with indeterminate cytology

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Karaki, Shino, Joji Mochida, Yoon Hwan Lee, Kazuhiro Nishimura, and Yutaka Tsutsumi. "Low-grade malignant perineurioma of the paravertebral column, transforming into a high-grade malignancy." Pathology International 49, no. 9 (1999): 820–25. http://dx.doi.org/10.1046/j.1440-1827.1999.00948.x.

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Creo, Ana, Fares Alahdab, Alaa Al Nofal, Kristen Thomas, Amy Kolbe, and Siobhan T. Pittock. "Ultrasonography and the American Thyroid Association Ultrasound-Based Risk Stratification Tool: Utility in Pediatric and Adolescent Thyroid Nodules." Hormone Research in Paediatrics 90, no. 2 (2018): 93–101. http://dx.doi.org/10.1159/000490468.

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Background: Pediatric thyroid nodules are more likely to be malignant compared to those in adults and may have different concerning ultrasound (US) features. Recent adult guidelines stratify malignancy risk by US features. Our aim is to (1) describe and confirm US features that predict pediatric malignancy, and (2) apply the Adult American Thyroid Association (ATA) Risk Stratification Guidelines to a large pediatric cohort. Methods: We identified 112 children with 145 thyroid nodules from 1996 to 2015. Two blinded pediatric radiologists independently read all US images, described multiple feat

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Nieto, Hannah, and Kristien Boelaert. "WOMEN IN CANCER THEMATIC REVIEW: Thyroid-stimulating hormone in thyroid cancer: does it matter?" Endocrine-Related Cancer 23, no. 11 (2016): T109—T121. http://dx.doi.org/10.1530/erc-16-0328.

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Differentiated thyroid cancer is the most common endocrine malignancy and the incidence is increasing rapidly worldwide. Appropriate diagnosis and post-treatment monitoring of patients with thyroid tumours are critical. Fine needle aspiration cytology remains the gold standard for diagnosing thyroid cancer, and although there have been significant refinements to this technique, diagnostic surgery is often required for patients suspected to have malignancy. Serum thyroid-stimulating hormone (TSH) is higher in patients with malignant thyroid nodules than in those with benign disease, and TSH is

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Langen, H. J., S. Koehler, J. Bielmeier, et al. "Microradiography of Microcalcifications in Breast Specimen: A New Histological Correlation Procedure and the Effect of Improved Resolution on Diagnostic Validity." Radiology Research and Practice 2012 (2012): 1–13. http://dx.doi.org/10.1155/2012/526293.

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Introduction. Does high-resolution visualization of microcalcifications improve diagnostic reliability?Method. X-rays were taken of mamma specimens with microcalcifications in 32 patients (10 malignant; 22 benign) using conventional radiography (12 Lp/mm) and high-resolution radiography (2000 Lp/mm). Histological sections were subsequently prepared and correlated to the microradiographic image and every calcification was assigned an exact malignant or benign histological diagnosis. Five radiologists classified single groups of calcifications in both methods according to the BIRADS classificati

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Hanselaar, A. G. J. M. "Additional Techniques in Serous Effusions." Analytical Cellular Pathology 24, no. 1 (2002): 1–4. http://dx.doi.org/10.1155/2002/376731.

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Cytological examination is a valuable diagnostic tool in case of a serous effusion. The firstmanifestation of malignancy may be an effusion of the pleural, pericardial, or peritoneal cavity, especially in carcinoma of the ovary, or lung, and malignant mesothelioma. In other malignancies effusions may occur in the course of the disease. The contribution by Motherby et al. in this issue of ACP focuses on the contribution of image and flow cytometry to establish the presence or absence of malignancy in serous effusions [16]. They point out that the sensitivity of DNA image cytometry in equivocal

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Cohen, David S., Jane E. Tongson-Ignacio, Christopher M. Lolachi, Vanessa S. Ghaderi, Babak Jahan-Parwar, and Lester D. R. Thompson. "Rethinking Malignancy Risk in Indeterminate Thyroid Nodules with Positive Molecular Studies: Southern California Permanente Experience." Otolaryngology–Head and Neck Surgery 161, no. 3 (2019): 419–23. http://dx.doi.org/10.1177/0194599819842859.

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Objectives To recognize that thyroid nodules with atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS; Bethesda III) have different risks of malignancy based on genetic mutation and to consider molecular testing of nodules with AUS/FLUS to help avoid unnecessary morbidity or cost. Study Design Retrospective cohort study. Setting Multiple locations within Southern California Permanente Medical Group. Subjects and Methods Patients included those with indeterminate thyroid nodules and AUS/FLUS on 2 separate fine-needle aspirations with positive ThyGenX tes

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Shoda, Waseem A. "Combine preoperative estimation of serum thyroglobulin and ACR-thyroid imaging reporting and data system scoring could accurately define malignant thyroid nodules." International Surgery Journal 8, no. 1 (2020): 32. http://dx.doi.org/10.18203/2349-2902.isj20205866.

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Background: Evaluation of diagnostic ability of preoperative estimation of serum thyroglobulin (TG) to detect malignant thyroid nodules (TN) in comparison to the American College of Radiology, Thyroid imaging reporting and data system (ACR-TIRADS), fine needle aspiration cytology (FNAC) and intraoperative frozen section (IO-FS).Methods: 34 patients with ACR-TIRADS 2-4 TN were evaluated preoperatively for identification of malignancy and all underwent total thyroidectomy with bilateral neck block dissection if indicated. Results of preoperative investigations were statistically analyzed using t

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Nikolic, B., and R. Lukic. "Choriocarcinoma – postdisease ultrasonographic findings." International Journal of Gynecologic Cancer 14, no. 4 (2004): 677–79. http://dx.doi.org/10.1136/ijgc-00009577-200407000-00017.

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This is a case report of consequences that malignant gestational trophoblastic disease (GTD) can cause on reproductive health protruding into uterine wall and damaging uterine tissue. Transvaginal Doppler ultrasound examination can be of great value in detecting molar tissue, protrusion of malignant trophoblast in uterine wall, and neovasularization in malignant tissue. It is expected to measure a low resistance index in a field of neovascularization, because neovascularization in malignancy is not rare and those vessels do not have muscular stratum. This case is an example of possible irrever

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Barman, Geetanjali, Kabita Bujarbaruah, Binoy Kumar Choudhury, and Amal Chandra Kataki. "Ultrasound evaluation of biopsy proven malignant breast mass." International Journal of Research in Medical Sciences 8, no. 2 (2020): 706. http://dx.doi.org/10.18203/2320-6012.ijrms20200261.

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Background: Breast cancer is the most common malignancy in female worldwide. Ultrasound (US) is a safe and easily available modality for evaluation of breasts in females of all age groups. It can detect characteristic features of breast malignancy with high degree of accuracy. This study was undertaken with the aims to evaluate the ultrasonographic features of malignant breast mass, to identify the most commonly encountered gray scale ultrasound findings and to study the role of Doppler ultrasound in those cases.Methods: The study was conducted in Dr B. Borooah Cancer Institute, Guwahati from

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WASEER, MUHAMMAD HUSSAIN, JAVAID IQBAL, and SAJID REHMAN RANDHAWA. "THYROID MALIGNANCY." Professional Medical Journal 14, no. 04 (2007): 573–79. http://dx.doi.org/10.29309/tpmj/2007.14.04.4807.

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Objectives: (1). Audit of our one year experience of management of thyroidcarcinoma in accordance with latest approved guidelines. (2) To point-out high risks of malignancy in population withthyroid diseases. Design: Prospective study. Setting: Surgical Unit-IV of DHQ Hospital Faisalabad with cooperationof Department of Pathology, Punjab Medical Collage, Faisalabad. Period: From 2000– 2001. Patients & method. Allpatients irrespective of age and sex with suspicious of thyroid malignancy were included in this study . Out of total 56patients of thyroid diseases 13 cases were proved thyroid ca

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Sugita, Reiji. "Magnetic resonance evaluations of biliary malignancy and condition at high-risk for biliary malignancy: Current status." World Journal of Hepatology 5, no. 12 (2013): 654. http://dx.doi.org/10.4254/wjh.v5.i12.654.

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Howard, Daniel, Ryan Rigby, and Kevin Winegar. "Primary High-Grade Squamous Cell Carcinoma of the Foot." Journal of the American Podiatric Medical Association 104, no. 5 (2014): 514–17. http://dx.doi.org/10.7547/0003-0538-104.5.514.

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Squamous cell carcinoma is the second most common type of skin cancer and may present in the distal extremities including the foot. We present a case in which a primary squamous cell carcinoma of the foot, which presented as a granulomatous ulcerating lesion, was diagnosed and successfully treated with a radical resection. Our case shows an atypical presentation of a very common malignancy and, it is therefore essential for health-care providers to consider malignancy in all suspicious lesions of the foot.

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Baral, Gehanath, Rijuta Joshi, and Benju Pandit. "Diagnostic Accuracy of Risk of Malignancy Indices in Ovarian Tumor." Journal of Nepal Health Research Council 18, no. 2 (2020): 253–58. http://dx.doi.org/10.33314/jnhrc.v18i2.2627.

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Background: Screening test for ovarian cancer has not been developed yet but several tools exist to predict it. The aim is to find out the relative accuracy of commonly practiced versions of Risk of Malignancy Indices to predict ovarian malignancy pre-operatively.Methods: Intention to treat cross sectional study at Paropakar Maternity and Women’s Hospital in Kathmandu during last six months of year 2018. Cases with ovarian mass were taken pre-operatively with serum tumor markers, ultrasound and tumor Doppler study report. Pregnancy and diagnosed malignancy were excluded. Histopathology report

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Woon, Tian K., Sarat K. Sanamandra, Parag R. Salkade, et al. "Subcentimetre thyroid nodules: Sonographic features associated with malignancy." Ultrasound 28, no. 3 (2020): 155–63. http://dx.doi.org/10.1177/1742271x20902159.

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Introduction The aim of this study was to identify the ultrasound features which are associated with malignancy in subcentimetre thyroid nodules. Methods This retrospective study included 454 thyroid nodules <10 mm in size in 413 patients from 2012 to 2016, which were subjected to fine needle aspiration cytology. Each nodule was classified according to the ultrasound patterns of the 2015 American Thyroid Association guidelines and the high suspicion ultrasound features (solid, hypo-echogenicity, irregular margins, microcalcifications, taller-than-wide, interrupted rim calcifications, and ex

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Mlika, Mouna, Adel Marghli, Ines Souilem, et al. "A single-institution experience of neurogenic tumors of the mediastinum." Asian Cardiovascular and Thoracic Annals 27, no. 8 (2019): 661–69. http://dx.doi.org/10.1177/0218492319878575.

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Background Neurogenic tumors of the mediastinum are rare tumors located mainly in the posterior mediastinum. The aim of this study was to report a single-institution experience of these tumors. Methods This study was conducted between 2005 and 2017. Bivariate analysis was performed to assess correlations between the cellularity, mitotic index, presence of a capsule, and potential for malignancy of peripheral nerve sheath tumors. Results There were 86 patients enrolled in the study. The mean age was 42.51 years. Nineteen patients were asymptomatic and their tumors were discovered incidentally.

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Negro, Roberto, Gabriele Greco, and Ermenegildo Colosimo. "Ultrasound Risk Categories for Thyroid Nodules and Cytology Results: A Single Institution’s Experience after the Adoption of the 2016 Update of Medical Guidelines by the American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi." Journal of Thyroid Research 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/8135415.

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Objectives. In 2016, the American Association of Clinical Endocrinologists (AACE) and Associazione Medici Endocrinologi (AME) released updated guidelines for the diagnosis and management of thyroid nodules. The aim of this study was to evaluate the AACE/AME recommendations for FNA in clinical practice, by comparing the (US) stratification risk and indications for FNA with cytologic results. Methods. From May to December 2016, we collected the cytologic results from FNAs of nodules that were classified using a three-tier US category system (low, intermediate, and high risk). Results. We obtaine

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Hunter, Alasdair. "High risk of malignancy in mosaic variegated aneuploidy syndrome." American Journal of Medical Genetics Part A 117A, no. 2 (2002): 199. http://dx.doi.org/10.1002/ajmg.a.10904.

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Schembri, J., MS Lau, and J. Hebden. "PTH-144 Anaemia of Chronic Disease: High Malignancy Yield." Gut 65, Suppl 1 (2016): A290.3—A291. http://dx.doi.org/10.1136/gutjnl-2016-312388.547.

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MacLeod, Craig, Robyn Cheuk, Mike Dally, et al. "Australian high-dose-rate brachytherapy protocols for gynaecological malignancy." Australasian Radiology 45, no. 1 (2001): 43–48. http://dx.doi.org/10.1046/j.1440-1673.2001.00872.x.

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Appolloni, I., M. Barilari, S. Caviglia, E. Gambini, E. Reisoli, and P. Malatesta. "A cadherin switch underlies malignancy in high-grade gliomas." Oncogene 34, no. 15 (2014): 1991–2002. http://dx.doi.org/10.1038/onc.2014.122.

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