Relevant bibliographies by topics / High resolution accurate mass (HRAM) mass spectrometry (MS)

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'High resolution accurate mass (HRAM) mass spectrometry (MS)'

Author: Grafiati
Published: 22 June 2024
Last updated: 31 July 2025

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Journal articles on the topic "High resolution accurate mass (HRAM) mass spectrometry (MS)"

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Hines, Jolaine M., Irina Bancos, Cristian Bancos, et al. "High-Resolution, Accurate-Mass (HRAM) Mass Spectrometry Urine Steroid Profiling in the Diagnosis of Adrenal Disorders." Clinical Chemistry 63, no. 12 (2017): 1824–35. http://dx.doi.org/10.1373/clinchem.2017.271106.

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Abstract BACKGROUND Steroid profiling is a promising diagnostic tool with adrenal tumors, Cushing syndrome (CS), and disorders of steroidogenesis. Our objective was to develop a multiple-steroid assay using liquid-chromatography, high-resolution, accurate-mass mass spectrometry (HRAM LC-MS) and to validate the assay in patients with various adrenal disorders. METHODS We collected 24-h urine samples from 114 controls and 71 patients with adrenal diseases. An HRAM LC-MS method was validated for quantitative analysis of 26 steroid metabolites in hydrolyzed urine samples. Differences in steroid ex
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Wiesinger, Thomas, Thomas Mechtler, Markus Schwarz та ін. "Investigating the suitability of high-resolution mass spectrometry for newborn screening: identification of hemoglobinopathies and β-thalassemias in dried blood spots". Clinical Chemistry and Laboratory Medicine (CCLM) 58, № 5 (2020): 810–16. http://dx.doi.org/10.1515/cclm-2019-0832.

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AbstractA fast and reliable method for the determination of hemoglobinopathies and thalassemias by high-resolution accurate mass spectrometry (HRAM/MS) is presented. The established method was verified in a prospective clinical study (HRAM/MS vs. high-pressure liquid chromatography [HPLC]) of 5335 de-identified newborn samples from the Hamburg area. The analytical method is based on a dual strategy using intact protein ratios for thalassemias and tryptic digest fragments for the diagnosis of hemoglobinopathies. Due to the minimal sample preparation and the use of flow injection, the assay can
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Lanzon, Borja, Marina Martin-Taboada, Victor Castro-Alves, et al. "Lipidomic and Metabolomic Signature of Progression of Chronic Kidney Disease in Patients with Severe Obesity." Metabolites 11, no. 12 (2021): 836. http://dx.doi.org/10.3390/metabo11120836.

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Severe obesity is a major risk for chronic kidney disease (CKD). Early detection and careful monitoring of renal function are critical for the prevention of CKD during obesity, since biopsies are not performed in patients with CKD and diagnosis is dependent on the assessment of clinical parameters. To explore whether distinct lipid and metabolic signatures in obesity may signify early stages of pathogenesis toward CKD, liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-high resolution accurate mass-mass spectrometry (GC-HRAM-MS) analyses were performed in the serum and the
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Ramanathan, Lakshmi, and Helen Shen. "LC–TOF–MS methods to quantify siRNAs and major metabolite in plasma, urine and tissues." Bioanalysis 11, no. 21 (2019): 1983–92. http://dx.doi.org/10.4155/bio-2019-0134.

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There are a few different bioanalytical approaches that have been used for the quantification of siRNA in biological matrices, such as S1 nuclease protection ‘cutting ELISA’, fluorescent probe hybridization HPLC, HPLC UV, LC–MS/high-resolution accurate-mass (HRAM) and LC–MS/MS. We have developed and validated plasma assays for several oligonucleotides such as GalNAc-conjugated siRNA, using uHPLC and high-resolution mass spectrometer by TOF detection. Although the molecular weights are in the range of 7000–9000, we were able to meet the same assay acceptance criteria as for the small molecules
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Yao, Jiaxu, Jinrui Zhu, Minjie Zhao, Li Zhou, and Eric Marchioni. "Untargeted Lipidomics Method for the Discrimination of Five Crab Species by Ultra-High-Performance Liquid Chromatography High-Resolution Mass Spectrometry Combined with Chemometrics." Molecules 28, no. 9 (2023): 3653. http://dx.doi.org/10.3390/molecules28093653.

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In this study, ultra-high-performance liquid chromatography high-resolution accurate mass-mass spectrometry (UHPLC-HRAM/MS) was applied to characterize the lipid profiles of five crab species. A total of 203 lipid molecular species in muscle tissue and 176 in edible viscera were quantified. The results indicate that Cancer pagurus contained high levels of lipids with a docosahexaenoic acid (DHA) and eicosapntemacnioc acid (EPA) structure in the muscle tissue and edible viscera. A partial least squares discriminant analysis (PLS-DA) showed that PE 16:0/22:6, PE P-18:0/20:5, PA 16:0/22:6 and PC
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Vanhee, Celine, Cloë Degrève, Niels Boschmans, et al. "Validated UHPLC Methods for Melatonin Quantification Reveal Regulatory Violations in EU Online Dietary Supplements Commerce." Molecules 30, no. 12 (2025): 2647. https://doi.org/10.3390/molecules30122647.

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The global sleep aids market has grown significantly due to rising stress and increased awareness of sleep’s importance. Melatonin, available in the EU as a prescription or over-the-counter medicine, depending on the country, is also permitted in dietary supplements with country-specific limits. Recent reports indicate concerning levels of excessive melatonin in EU dietary supplements, necessitating accurate quantification methods. We developed and validated, by applying accuracy profiles, ISO17025-compliant, rapid ultra-high performance liquid chromatography (UHPLC) methodologies coupled with
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Byrdwell, William C., and Hari Kiran Kotapati. "Multi-Dimensional Liquid Chromatography of Pulse Triacylglycerols with Triple Parallel Mass Spectrometry." Separations 10, no. 12 (2023): 594. http://dx.doi.org/10.3390/separations10120594.

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We analyzed ten pulses (the dried seeds of legumes), i.e., baby lima beans, black beans, black-eyed peas, butter beans, cranberry beans, garbanzo beans, green split peas, lentils, navy beans, and pinto beans, using three-dimensional liquid chromatography (3D-LC) with parallel second dimensions, LC × (LC + LC). We combined non-aqueous reversed-phase (NARP) chromatography as the first dimension separation, 1D, with argentation UHPLC for separation based on degree and location of unsaturation in the first second dimension, 2D(1), and multi-cycle NARP-UHPLC in the second second dimension, 2D(2). P
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Kiyonami, Reiko, Rafael Melani, Ying Chen, AI De Leon, and Min Du. "Applying UHPLC-HRAM MS/MS Method to Assess Host Cell Protein Clearance during the Purification Process Development of Therapeutic mAbs." International Journal of Molecular Sciences 25, no. 17 (2024): 9687. http://dx.doi.org/10.3390/ijms25179687.

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Host cell proteins (HCPs) are one of the process-related impurities that need to be well characterized and controlled throughout biomanufacturing processes to assure the quality, safety, and efficacy of monoclonal antibodies (mAbs) and other protein-based biopharmaceuticals. Although ELISA remains the gold standard method for quantification of total HCPs, it lacks the specificity and coverage to identify and quantify individual HCPs. As a complementary method to ELISA, the LC-MS/MS method has emerged as a powerful tool to identify and profile individual HCPs during the downstream purification
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Moore, Eli K., Ellen C. Hopmans, W. Irene C. Rijpstra, et al. "Novel Mono-, Di-, and Trimethylornithine Membrane Lipids in Northern Wetland Planctomycetes." Applied and Environmental Microbiology 79, no. 22 (2013): 6874–84. http://dx.doi.org/10.1128/aem.02169-13.

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ABSTRACTNorthern peatlands represent a significant global carbon store and commonly originate fromSphagnummoss-dominated wetlands. These ombrotrophic ecosystems are rain fed, resulting in nutrient-poor, acidic conditions. Members of the bacterial phylumPlanctomycetesare highly abundant and appear to play an important role in the decomposition ofSphagnum-derived litter in these ecosystems. High-performance liquid chromatography coupled to high-resolution accurate-mass mass spectrometry (HPLC-HRAM/MS) analysis of lipid extracts of four isolated planctomycetes from wetlands of European north Russ
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Sternberg, Johanna, Insa Peters, Nana Naumann, Andreas Thomas, and Mario Thevis. "In Vitro Metabolism of Doping Agents (Stanozolol, LGD-4033, Anastrozole, GW1516, Trimetazidine) by Human Seminal Vesicle and Liver Fractions." Metabolites 15, no. 7 (2025): 452. https://doi.org/10.3390/metabo15070452.

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Background: In order to address complex scenarios in anti-doping science, especially in cases where an unintentional exposure of athletes to prohibited substances and a corresponding contamination of doping control samples at the collection event are argued, an understanding of tissue-specific drug metabolism is essential. Hence, in this study, the metabolic capacity of the seminal vesicle using in vitro assays was investigated. Methods: The aim was to assess whether selected doping-relevant substances—stanozolol, LGD-4033, GW1516, trimetazidine, and anastrozole—are metabolised in seminal vesi
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Dissertations / Theses on the topic "High resolution accurate mass (HRAM) mass spectrometry (MS)"

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Maknun, Luluil. "Development of mass spectrometric analytical methods for the determination of iron complexes in plants and bacteria and for the determination of cobalt using bimetallic nanoparticles." Electronic Thesis or Diss., Pau, 2023. http://www.theses.fr/2023PAUU3039.

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L'objectif principal de cette recherche est le développement de méthodes analytiques utilisant une technique de séparation couplée à la spectrométrie de masse pour l'analyse de complexes de fer de faible poids moléculaire et une technique de single-particle ICP MS pour la détection de nanoparticules bimétalliques.Dans la première partie, une méthode utilisant la chromatographie liquide avec spectrométrie de masse à double détecteur, spectrométrie de masse (MS) à haute résolution par électrospray (HRAM) et spectrométrie de masse à couplage inductif (ICPMS), a été développée pour les complexes d
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Huang, Fan. "APPLICATION OF HIGH-RESOLUTION ACCURATE MASS (HRAM) MASS SPECTROMETRY FOR ANALYSIS OF LIGNIN MODEL COMPOUNDS AND THE POST-PRETREATMENT PRODUCTS." UKnowledge, 2017. http://uknowledge.uky.edu/chemistry_etds/74.

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Lignin, one of main components in the woody cell walls, is a complex heterogeneous biopolymer, which provides structural support and transportation of water in plants. It is highly recalcitrant to degradation (both chemically and environmentally) and protects cellulose from being degraded/hydrolyzed. Due to the structural complexity of native lignin, complete characterization and elucidation of lignin’s structure remains very challenging. The overarching goal of this work is to develop mass spectrometry based analytical methods to contribute to a better understanding of lignin structures. This
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Broecker, Sebastian. "Aufbau und Anwendung einer Methode zur Identifizierung und Quantifizierung von Giften und deren Metaboliten in Blut und Haaren in der Systematischen Toxikologischen Analyse mittels Flüssigchromatographie-Quadrupol-Flugzeitmassenspektrometrie-Kopplung (LC-QTOF-MS)." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16461.

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Die Systematische Toxikologische Analyse (STA) stellt auf Grund der großen Vielfalt und der ständigen Zunahme an toxikologisch relevanten Substanzen eine der größten Herausforderungen in der chemischen Analyse dar. In der vorliegenden Arbeit wurde daher die Eignung der Flüssigchromatographie in Kombination mit der Hybrid-Quadrupol-Flugzeitmassenspektrometrie (LC-QTOF-MS) für diesen Zweck untersucht. Dazu wurden eine Datenbank mit über 7360 und eine CID-Spektrenbibliothek mit mehr als 2720 toxikologisch relevanten Substanzen erstellt und geeignete Probenvorbereitungsmethoden entwickelt. Die Erp
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Larabi, Islam Amine. "Nouveaux produits de synthèse : analyse, consommation et métabolisme ; Applications cliniques et médicolégales Rapid and simultaneous screening of new psychoactive substances and conventional drugs of abuse. A comparative study of Biochip Array Technology versus LC-MS/MS in whole blood and urine Development of a sensitive untargeted liquid chromatography– high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances Validation of an UPLC-MS/MS method for the determination of sixteen synthetic cannabinoids in human hair. Application to document chronic use of JWH-122 following a non-fatal overdose Development and validation of liquid chromatography-tandem mass spectrometry targeted screening of 16 fentanyl analogs and U-47700 in hair: Application to 137 authentic samples Prevalence and Surveillance of Synthetic Cathinones Use by Hair Analysis: An Update Review Prevalence of New Psychoactive Substances(NPS) and conventional drugs of abuse (DOA) in high risk populations from Paris(France) and its suburbs A cross sectional study by hair testing(2012–2017) Evaluation of drug abuse by hair analysis and self-reported use among MSM under PrEP: Results from a sub-study of the ANRS-IPERGAY trial. Hair testing for 3‑fluorofentanyl, furanylfentanyl, methoxyacetylfentanyl, carfentanil, acetylfentanyl and fentanyl by LC–MS/MS after unintentional overdose Drug‐facilitated sexual assault (DFSA) involving 4‐methylethcathinone (4‐MEC),3,4‐Methylenedioxypyrovalerone (MDPV), and doxylamine highlighted by hair analysis Metabolic Profiling of Deschloro-N-ethyl-ketamine (O-PCE) and identification of new target metabolites in urine and hair using human liver microsomes and high-resolution accurate mass spectrometry." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL029.

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L’objectif de ce travail a été de développer deux approches analytiques dédiées à l’analyse toxicologique des nouveaux produits de synthèse (NPS) dans différentes matrices biologiques (sang, urine et cheveux). La première est basée sur le criblage non ciblé par chimiluminescence sur biopuces et chromatographie liquide couplée à la spectrométrie de masse haute résolution (LC-HRMS) et la deuxième correspond à un criblage ciblé par spectrométrie de masse en tandem (LC-MS/MS). Ces deux approches ont ensuite été appliquées dans des études observationnelles pour évaluer la consommation de NPS dans d
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Book chapters on the topic "High resolution accurate mass (HRAM) mass spectrometry (MS)"

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Crutchfield, C. A., and W. Clarke. "High resolution accurate mass (HRAM) mass spectrometry." In Mass Spectrometry for the Clinical Laboratory. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-800871-3.00012-2.

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McCullagh, James, and Neil Oldham. "Resolution, accurate mass, and sensitivity." In Mass Spectrometry. Oxford University Press, 2019. http://dx.doi.org/10.1093/hesc/9780198789048.003.0004.

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This chapter explains resolving power, resolution, accurate mass, and sensitivity, and shows how these properties can be used for analytical purposes. It highlights the key properties of a mass spectrometer, which include the limit to which an instrument can separate ions of different m/z value and the error limit within which an instrument can measure an ion's m/z value relative to its theoretical value. It also refers to the relationship between the ion current measured by the mass spectrometer and the concentration of the sample analyte. The chapter clarifies that analyzers with high resolv
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Gangwar, Shivanshu, Rohit Kumar, Mandeep Yadav, Himanshi Rathaur, and Rizwan Ahmad. "ROLE OF LC-MS IN HIGH-THROUGHPUT SCREENING OF BIOMARKER." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 9. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bipn9ch12.

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The identification and quantification of biomarkers play a crucial role in biomedical research and clinical diagnostics. High throughput screening (HTS) methods have emerged as powerful tools for rapidly assessing numerous biomolecules across large sample sets. Liquid chromatography-mass spectrometry (LC-MS) has become a leading technology in biomarker analysis due to its unparalleled sensitivity, selectivity, and versatility. This abstract aim to explore the pivotal role of LC-MS in HTS of biomarker analysis. We begin by highlighting the importance of biomarkers as key indicators of biologica
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Conference papers on the topic "High resolution accurate mass (HRAM) mass spectrometry (MS)"

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Byrdwell, William, and Hari Kiran Kotapati. "Fast chromatography with dual parallel mass spectrometry for lipidomic analysis and regioisomer quantification of pulse lipids." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/kxye7490.

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Pulses are seeds produced from legumes. More specifically, the United Nations Food and Agricultural Organization (FAO) defines pulses as “Leguminosae crops harvested exclusively for their grain, including dry beans, peas and lentils”. This excludes oilseeds, such as soybeans and peanuts. Pulses are well known for their high content of protein and fiber. Most pulses do not contain a lot of oil, and there is not abundant information in the literature on pulse oil triglycerides, or triacylglycerols (TAGs). But pulses are consumed in large quantities in diets around the globe, so even lower am
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Ow, Hooisweng, Sehoon Chang, Gawain Thomas, Wei Wang, Afnan A. Mashat, and Hussein Shateeb. "Automatable High Sensitivity Tracer Detection: Toward Tracer Data Enriched Production Management of Hydrocarbon Reservoirs." In SPE Annual Technical Conference and Exhibition. SPE, 2021. http://dx.doi.org/10.2118/206338-ms.

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Abstract The development of automatable high sensitivity analytical methods for tracer detection has been one of the most central challenges to realize ubiquitous full-field tracer deployment to study reservoirs with many cross-communicating injector and producer wells. Herein we report a tracer analysis approach, inspired by strategies commonly utilized in the biotechnology industry, that directly addresses key limitations in process throughput, detection sensitivity and automation potential of state-of-the-art technologies. A two-dimensional high performance liquid chromatography (2D-HPLC) m
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Santos, Luiz, Tom Buchanan, Kristina Srzentic, Kai Scheffler, Sara Carillo, and Jonathan Bones. "Characterization of an IgG1 monoclonal antibody oxidation variants at intact, subunit and peptide levels by High Resolution Accurate Mass (HRAM) mass spectrometry." In International Symposium on Immunobiological. Instituto de Tecnologia em Imunobiológicos, 2024. http://dx.doi.org/10.35259/isi.biomang.2024_63764.

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Wei, Na, Enada Archibold, Grace Jairo, and Heather Kuiper. "Development of a method for separation of geometric isomers of alpha-linolenic acid in human plasma by silver Ion HPLC and GC-NCI-MS." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/fvyw5862.

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Alpha-linolenic acid (ALA), an omega-3 fatty acid essential for humans, must be supplied by diet, mainly from plants. It's a precursor of omega-3 long-chain fatty acids, eicosapentaenoic and docosahexaenoic acids which are essential for human cardiovascular health. ALA consumption may also reduce the risk of heart disease. The geometric isomers of ALA in humans are derived from consumption of industrially produced partially hydrogenated and deodorized vegetable oils. The presence of trans-isomers of ALA in humans may affect the levels of regular ALA, potentially impacting the beneficial effect
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Koksalan, T., K. A. Khan, R. Alhadhrami, A. Salahuddin, E. Warsito, and T. Ruble. "Cracking the Code: High Oil Saturation Without Oil Production? A Game-Changing Novel Geochemical Methodology for Assessing Total, Mobile/Immobile and EOR Oil; A Case Study from Abu Dhabi, UAE." In ADIPEC. SPE, 2024. http://dx.doi.org/10.2118/222868-ms.

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ABSTRACT It is a common yet perplexing phenomenon in the oil industry that high-saturation zones, as indicated by petrophysical measurements, are frequently perforated and tested, yet they often yield negligible or no oil flow, which can be quite puzzling and disappointing. Additionally, the original oil in place (OOIP) is typically estimated through conventional core analysis techniques and geochemical tests, such as programmed non-isothermal pyrolysis. However, these estimates are often revised over the lifecycle of the field as the actual OOIP values are found to deviate from the predicted
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Luo, Pan, Jonathan Harrist, Rabah Mesdour, and Nathan Stmichel. "Moving Gas Geochemical Analysis from Lab to Field by Advanced Gas Sensor for Onsite Fluid Characterization and Time-Lapse Monitoring." In SPE Middle East Oil & Gas Show and Conference. SPE, 2021. http://dx.doi.org/10.2118/204775-ms.

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Abstract Natural gas is sampled or produced throughout the lifespan of a field, including geochemical surface survey, mud gas logging, formation and well testing, and production. Detecting and measuring gas is a common practice in many upstream operations, providing gas composition and isotope data for multiple purposes, such as gas show, petroleum system analysis, fluid characterization, and production monitoring. Onsite gas analysis is usually conducted within a mud gas unit, which is operationally unavailable after drilling. Gas samples need be taken from the field and shipped back to labor
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