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Journal articles on the topic 'High risk junctions'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Wu, Peijie, Xianghai Meng, Li Song, and Wenze Zuo. "Crash Risk Evaluation and Crash Severity Pattern Analysis for Different Types of Urban Junctions: Fault Tree Analysis and Association Rules Approaches." Transportation Research Record: Journal of the Transportation Research Board 2673, no. 1 (2019): 403–16. http://dx.doi.org/10.1177/0361198118822817.

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Urban junctions usually present significant safety concerns, and the majority of all crashes in urban areas occur in or near junctions. Factors contributing to crash severity at junctions have been explored, but crash risk levels and crash severity patterns of different junction types have hardly been investigated. In order to fill this gap, this study analyzed the safety performance of six junction types and the factors contributing to crash severity, in order to assist city transportation authorities to implement effective countermeasures. Fault tree analysis (FTA) was applied for the risk e

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Stelow, Edward B., Erik A. Dill, Jonathan J. Davick, Michael B. McCabe, and Vanessa M. Shami. "High-Grade Squamous Intraepithelial Lesion of the Gastroesophageal Junction Secondary to High-Risk Human Papillomavirus." American Journal of Clinical Pathology 152, no. 3 (2019): 359–64. http://dx.doi.org/10.1093/ajcp/aqz039.

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ABSTRACT Objectives Although the role of human papillomavirus (HPV) in the development of some carcinomas (eg, anogenital and oropharyngeal squamous cell carcinomas) is nondebatable, there is still significant controversy regarding the relationship of HPV and esophageal squamous cell carcinomas (SCCs). Methods All cases were sampled at or near the gastroesophageal junctions in patients with reflux and/or known Barrett esophagus and appear to have been initially sampled “incidentally.” Patients were all men, aged 56 to 80 years. None had a known history of other HPV-related disease. Results We

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Nta, Samuel Akpan, Erewari Ukoha-Onuoha, Ikpe Jimmy Udom, and Unwana Iniobong Udoumoh. "Concentration and Health Risk Assessment of Heavy Metal in Roadside Soil in Eket, Akwa Ibom State, Nigeria." Asian Soil Research Journal 9, no. 2 (2025): 122–32. https://doi.org/10.9734/asrj/2025/v9i2185.

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Aims: This study determines the heavy metal impacts on roadside soils and its potential health hazards in Eket, Akwa Ibom State, Nigeria. Background: Roads affect natural environment to a large extent because automobile act as line sources of heavy metal pollutants. Emission from heavy traffic have been reported to contain Pb, Cd, Zn and Ni which are present in fuel as anti-knock agent. Heavy metals in the soil can also generate airborne particles and dust which may affect the quality of air. Inhalation of substantial quantities of heavy metal particle over period of time may add to human body

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Storrs, Carina H., and Saul J. Silverstein. "PATJ, a Tight Junction-Associated PDZ Protein, Is a Novel Degradation Target of High-Risk Human Papillomavirus E6 and the Alternatively Spliced Isoform 18 E6*." Journal of Virology 81, no. 8 (2007): 4080–90. http://dx.doi.org/10.1128/jvi.02545-06.

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ABSTRACT The E6 protein from high-risk human papillomavirus types interacts with and degrades several PDZ domain-containing proteins that localize to adherens junctions or tight junctions in polarized epithelial cells. We have identified the tight junction-associated multi-PDZ protein PATJ (PALS1-associated TJ protein) as a novel binding partner and degradation target of high-risk types 16 and 18 E6. PATJ functions in the assembly of the evolutionarily conserved CRB-PALS1-PATJ and Par6-aPKC-Par3 complexes and is critical for the formation of tight junctions in polarized cells. The ability of t

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Wu, Aiming, Mingjing Zhao, Lixia Lou, et al. "Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction." BioMed Research International 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/3495021.

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Myocardial infarction (MI) patients are at high risk of potential lethal arrhythmia. Gap junction and microRNA-1 (miR-1) are both arrhythmia generating conditions. The present study investigated whether Wenxin Granules (Wenxin-Keli, WXKL) could prevent potential lethal arrhythmia by improving gap junctions and miR-1 following MI. Male Sprague-Dawley rats were divided randomly into control, model, metoprolol, low dose WXKL, and high dose WXKL groups. The MI rat model was created by coronary artery ligation. Treatments were administrated intragastrically to the rats for 4 weeks. Conventional tra

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Nakagawa, Shunsuke, and Jon M. Huibregtse. "Human Scribble (Vartul) Is Targeted for Ubiquitin-Mediated Degradation by the High-Risk Papillomavirus E6 Proteins and the E6AP Ubiquitin-Protein Ligase." Molecular and Cellular Biology 20, no. 21 (2000): 8244–53. http://dx.doi.org/10.1128/mcb.20.21.8244-8253.2000.

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ABSTRACT The high-risk human papillomavirus (HPV) E6 proteins stimulate the ubiquitination and degradation of p53, dependent on the E6AP ubiquitin-protein ligase. Other proteins have also been shown to be targeted for degradation by E6, including hDlg, the human homolog of the Drosophila melanogaster Discs large (Dlg) tumor suppressor. We show here that the human homolog of theDrosophila Scribble (Vartul) (hScrib) tumor suppressor protein is also targeted for ubiquitination by the E6-E6AP complex in vitro and that expression of E6 induces degradation of hScrib in vivo. Characterization of the

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Bischel, Oliver E., Arnold J. Suda, Paul M. Böhm, Therese Bormann, Sebastian Jäger, and Jörn B. Seeger. "Breakage of Tapered Junctions of Modular Stems in Revision Total Hip Arthroplasty—High Incidence in a Consecutive Series of a Single Institution." Bioengineering 10, no. 3 (2023): 341. http://dx.doi.org/10.3390/bioengineering10030341.

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Background: Modularity in revision THA (RTHA) has become accepted during the last three decades. Nevertheless, specific risks of modularity of current revision devices such as breakage of taper junctions occur during follow-up. Data reporting failure rates are predominantly given by the manufacturers but independent data acquisition is missing so far. Questions/Purposes: 1. What time-related risk of breakage of taper junction between neck and body of an established modular revision device can be expected in a consecutive single institutional series and a mid-term follow-up? 2. Are there specif

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Karpenko, Mykola, Olegas Prentkovskis, and Šarūnas Šukevičius. "Research on high-pressure hose with repairing fitting and influence on energy parameter of the hydraulic drive." Eksploatacja i Niezawodnosc - Maintenance and Reliability 24, no. 1 (2021): 25–32. http://dx.doi.org/10.17531/ein.2022.1.4.

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Reliability and maintenance analysis of transport machines hydraulic drives, basically focused to power units: pumps, cylinders etc., without taking in to account junction elements. Therefore, this paper proposes a research analysis on high-pressure hoses and junctions during technical maintenance. Comparative analysis of fluid behavior and energy efficiency inside non-repaired and repaired high-pressure hoses is presented in this research. Theoretical and experimental research results for hydraulic processes inside high-pressure hose is based on the numerical simulations using Navier–Stokes e

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Miyamoto-Mikami, Eri, Hiroshi Kumagai, Naoki Kikuchi, Nobuhiro Kamiya, Naokazu Miyamoto, and Noriyuki Fuku. "eQTL variants in COL22A1 are associated with muscle injury in athletes." Physiological Genomics 52, no. 12 (2020): 588–89. http://dx.doi.org/10.1152/physiolgenomics.00115.2020.

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The myotendinous junction (MTJ) is at high risk of muscle injury, and collagen XXII is strictly expressed at tissue junctions, specifically at the MTJ. We investigated the hypothesis that single-nucleotide polymorphisms (SNPs) related to collagen type XXII α-1 chain gene ( COL22A1) mRNA expression are associated with susceptibility to muscle injury in athletes. History of muscle injury was assessed in 3,320 Japanese athletes using a questionnaire, and two expression quantitative trait loci (eQTL) SNPs for COL22A1 (rs11784270 A/C and rs6577958 T/C) were analyzed using the TaqMan SNP Genotyping

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Shen, Jun, Xiao-Chang Chen, Wang-Jun Li, et al. "Identification of Parkinson’s disease-related pathways and potential risk factors." Journal of International Medical Research 48, no. 10 (2020): 030006052095719. http://dx.doi.org/10.1177/0300060520957197.

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Objective To identify Parkinson’s disease (PD)-associated deregulated pathways and genes, to further elucidate the pathogenesis of PD. Methods Dataset GSE100054 was downloaded from the Gene Expression Omnibus, and differentially expressed genes (DEGs) in PD samples were identified. Functional enrichment analyses were conducted for the DEGs. The top 10 hub genes in the protein–protein interaction (PPI) network were screened out and used to construct a support vector machine (SVM) model. The expression of the top 10 genes was then validated in another dataset, GSE46129, and a clinical patient co

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Daya, Shankar Pandey, and Agarwal P.K. "Assessment of Safety Risk for Signalized and Un-signalized Intersection in a Road Network." International Journal of Recent Technology and Engineering (IJRTE) 9, no. 4 (2020): 13–17. https://doi.org/10.35940/ijrte.B2107.119420.

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The spectacular increase of number of motor vehicles on the road is mainly attributed ingeneration of traffic problems like accidents, congestions, delays etc., especially in the urban premises of developing countries. This paper examines the traffic problems and sustainable improvement of road intersection at Bhopal, India. The special and temporal constitutions of the vehicle as well as pedestrian traffic at the intersections were examined and the characteristics of the junction indoctrinating the delay problems are identified. Data regarding the traffic volume, land use and pedestrian movem

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Park, Zion, Gunwoo Lee, Choongheon Yang, and Jin-Kak Lee. "Factors Affecting Rear-End Collisions in Underground Road Junctions Using VISSIM." Applied Sciences 14, no. 18 (2024): 8509. http://dx.doi.org/10.3390/app14188509.

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Due to urban overcrowding, available land is limited and traffic congestion has increased. Underground roads are being built to mitigate traffic congestion as an alternative. Studies associated with underground roads are needed because these roads are dark and closed and have a high risk of accidents compared to surface roads. In particular, there is limited study on junctions that connect two or more underground roads. In this study, an underground road network including junctions was constructed to analyze the factors behind rear-end collisions at underground road connections. To reflect the

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Ghosh, Poulami, Subrata Biswas, and Prithwiraj Purkait. "Methodology for incisive foraging of high-risk junctions and elimination of injected false data in smart grid." International Journal of Applied Power Engineering (IJAPE) 14, no. 2 (2025): 347. https://doi.org/10.11591/ijape.v14.i2.pp347-358.

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The present work represents a method for identification of the vulnerable nodes in smart grid as well as assessment of the performance of voltage stability indicator technique with the help of weighted least square scheme. in today’s smart grid system, false data injection (FDI) is the major issue to supply uninterruptedly at demand side in advanced metering infrastructure (AMI). The recent blackouts are the consequence of non-identifying FDI as research on FDI is not considered under power system analysis. In our research, vulnerable nodes of a power system network have been identified and a

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Huang, Shu-Hung, Yun-Nan Lin, Su-Shin Lee, et al. "Three Simple Steps for Refining Transcutaneous Lower Blepharoplasty for Aging Eyelids: The Indispensability of Micro-Autologous Fat Transplantation." Aesthetic Surgery Journal 39, no. 11 (2019): 1163–77. http://dx.doi.org/10.1093/asj/sjz005.

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AbstractBackgroundLower blepharoplasty has been used for rejuvenating lower eyelids, and diverse modifications have been used to treat conjunct deformities at the tear trough/lid-cheek junction. Strategies for recontouring prominent tear trough/lid-cheek junctions, including orbital fat manipulation, have been reported with good results in the literature. Micro-autologous fat transplantation (MAFT) is a previously unevaluated, potentially advantageous approach to blending the prominent tear trough/lid-cheek junction.ObjectivesWe determined the long-term results after 3-step transcutaneous lowe

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Ahn, Eunyong, Se Ik Kim, Sungmin Park, et al. "Abstract 1065: Two-step method for early detection of ovarian cancer with high specificity via platelet RNA." Cancer Research 84, no. 6_Supplement (2024): 1065. http://dx.doi.org/10.1158/1538-7445.am2024-1065.

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Abstract Owing to lack of disease-specific symptoms and screening methods, most of patients with ovarian cancer are diagnosed at an advanced stage. Recent technology based on platelet RNA aids in detection of tumors at the early stages. Also, for population screening of low-prevalence diseases like cancer, accurate detection with high specificity is essential to improve diagnostic methods. Thus, we proposed platelet RNA-based early ovarian cancer detection with great specificity. It is a two-step method for detecting ovarian tumors with more than 99% specificity using exon-exon junction featur

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Li, Hui, Ruifen Zhang, Yupin Cai, et al. "Determination of Integrated HPV58 Sequences in Cervical Lesions." International Journal of Gynecologic Cancer 22, no. 7 (2012): 1234–37. http://dx.doi.org/10.1097/igc.0b013e31825d4716.

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Integration of high-risk HPV in host genome is an important event in cervical cancer development. This study was aimed to analyze the integration of HPV58, a high-risk type that is prevalent in cervical lesions from southeastern Asia. Detection of integrated papillomavirus sequences by ligation-mediated polymerase chain reaction followed by DNA sequencing revealed 8 integrations in 5 samples, and virus integration was found present in 2 samples with early lesion. Sequence analysis of the viral-cellular junctions showed that E1 disruption in virus genome was an early and common event during HPV

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Ziolkowski, Robert. "The Influence of Roundabouts on Drivers’ Speed and Behaviour." Advanced Materials Research 1020 (October 2014): 674–79. http://dx.doi.org/10.4028/www.scientific.net/amr.1020.674.

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Driving speed is one of the most important factors in road safety and speed not only affects the severity of a crash, but is also related to the risk of being involved in a crash. Inappropriate speed is responsible for more than a third of all fatal accidents occurring on roads. In Poland every year about 70% of all traffic accidents occur in urban areas from which most is recorded at junctions. In order to improve traffic safety many efforts have been undertaken but their performance is still not satisfactory. One of the solutions for improving safety in cities is designing new and replacing

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Yee, Wai Mun, Mario Paniccia, Travis Eiles, and Valluri Rao. "Laser Voltage Probe (LVP): A Novel Optical Probing Technology for Flip-Chip Packaged Microprocessors." EDFA Technical Articles 2, no. 3 (2000): 20–25. http://dx.doi.org/10.31399/asm.edfa.2000-3.p020.

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Abstract Laser voltage probing (LVP), an IR-based technique, facilitates through-silicon signal waveform acquisition and high frequency timing measurements from active p-n junctions on CMOS ICs. The ICs can be in flip-chip as well as wire-bond packages with backside access to the IC. As the article explains, LVP significantly improves silicon debug and failure analysis throughput time compared to electron-beam probing because it eliminates the need for backside trenching and probe-hole generating operations.

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Feeney, A. J. "Predominance of the prototypic T15 anti-phosphorylcholine junctional sequence in neonatal pre-B cells." Journal of Immunology 147, no. 12 (1991): 4343–50. http://dx.doi.org/10.4049/jimmunol.147.12.4343.

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Abstract The primary antibody response to phosphorylcholine (PC) is dominated by T15 antibodies. There are three families of anti-PC antibodies which can be made in mice: T15, 511, and 603. All use the same H chain V, D, and J segments, but each anti-PC family has a different L chain, as well as a family-specific Vh-D junctional sequence. Here we test the hypothesis that T15 antibodies are dominant because the prototypic T15 V-D junction is generated in pre-B cells more often than the alternative non-T15 V-D junctional sequences. Rearranged IgH genes from DNA derived from fetal or newborn live

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Sharafutdinov, Irshad, Nicole Tegtmeyer, Mathias Müsken, and Steffen Backert. "Campylobacter jejuni Serine Protease HtrA Induces Paracellular Transmigration of Microbiota across Polarized Intestinal Epithelial Cells." Biomolecules 12, no. 4 (2022): 521. http://dx.doi.org/10.3390/biom12040521.

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Campylobacter jejuni represents an eminent zoonotic germ responsible for foodborne infections causing campylobacteriosis. In addition, infections with C. jejuni constitute a risk factor for the occurrence of inflammatory bowel disease (IBD). In the latter case, patients show inflammatory reactions not only against C. jejuni, but also against the non-infectious microbiota. However, the involved mechanisms and molecular basis are still largely unclear. We recently reported that C. jejuni breaches the intestinal epithelial barrier by secretion of serine protease HtrA (high temperature requirement

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M Miller, David, Akinori Yoda, Yuka Yoda, and David M. Weinstock. "Mechanisms of CRLF2 Rearrangement with IGH and P2RY8 in B-Cell Acute Lymphoblastic Leukemia." Blood 114, no. 22 (2009): 3243. http://dx.doi.org/10.1182/blood.v114.22.3243.3243.

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Abstract Abstract 3243 Poster Board III-180 Introduction Precursor B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy in children. While the great majority of these children achieve long-term remission, the disease exacts a high mortality in adults, and children with high-risk features. Fusion oncogenes such as BCR-ABL, MLL-AF4, E2A-PBX and TEL-AML1 are present in 60% of B-ALL cases. Cloning of these rearrangements has provided significant insight into the mechanisms involved in their formation. The gene alterations that affect the remaining 40% are poorly understood. We

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Burger, Evalina L., Andriy Noshchenko, Vikas V. Patel, Emily M. Lindley, and Andrew P. Bradford. "Ultrastructure of Intervertebral Disc and Vertebra-Disc Junctions Zones as a Link in Etiopathogenesis of Idiopathic Scoliosis." Advances in Orthopedic Surgery 2014 (March 23, 2014): 1–23. http://dx.doi.org/10.1155/2014/850594.

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Background Context. There is no general accepted theory on the etiology of idiopathic scoliosis (IS). An important role of the vertebrae endplate physes (VEPh) and intervertebral discs (IVD) in spinal curve progression is acknowledged, but ultrastructural mechanisms are not well understood. Purpose. To analyze the current literature on ultrastructural characteristics of VEPh and IVD in the context of IS etiology. Study Design/Setting. A literature review. Results. There is strong evidence for multifactorial etiology of IS. Early wedging of vertebra bodies is likely due to laterally directed ap

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Shi, Xiaokai, Xiao Zhou, Chuang Yue, et al. "A Five Collagen-Related Gene Signature to Estimate the Prognosis and Immune Microenvironment in Clear Cell Renal Cell Cancer." Vaccines 9, no. 12 (2021): 1510. http://dx.doi.org/10.3390/vaccines9121510.

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Collagen is the main component of the extracellular matrix (ECM) and might play an important role in tumor microenvironments. However, the relationship between collagen and clear cell renal cell cancer (ccRCC) is still not fully clarified. Hence, we aimed to establish a collagen-related signature to predict the prognosis and estimate the tumor immune microenvironment in ccRCC patients. Patients with a high risk score were often correlated with unfavorable overall survival (OS) and an immunosuppressive microenvironment. In addition, the collagen-related genetic signature was highly correlated w

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Zeng, Huawei, Bryan Safratowich, Wen-Hsing Cheng, Kate Claycombe-Larson, and Mary Briske-Anderson. "Deoxycholic Acid Modulates Cell-Junction Gene Expression and Increases Intestinal Barrier Dysfunction in Caco-2 Cell Monolayers." Current Developments in Nutrition 5, Supplement_2 (2021): 956. http://dx.doi.org/10.1093/cdn/nzab050_023.

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Abstract Objectives Diet-related obesity is associated with an increased risk of developing intestinal hyperpermeability. High dietary fat intake causes an increase in colonic bile acids (BAs), particularly deoxycholic acid (DCA, secondary BA), which may disrupt the intestinal epithelial barrier. To determine the potential role of bile acids in barrier dysfunction, we hypothesize that DCA modulates the gene expression in multiple cell junction pathways and increases intestinal permeability. Methods With a Caco-2 cell intestinal barrier model, we used cell proliferation, PCR array, biochemical,

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Kim, Sanggu, Namshin Kim, Angela P. Presson, et al. "High-Throughput, Sensitive Quantification of Repopulating Hematopoietic Stem Cell Clones." Journal of Virology 84, no. 22 (2010): 11771–80. http://dx.doi.org/10.1128/jvi.01355-10.

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ABSTRACT Retroviral vector-mediated gene therapy has been successfully used to correct genetic diseases. However, a number of studies have shown a subsequent risk of cancer development or aberrant clonal growths due to vector insertion near or within proto-oncogenes. Recent advances in the sequencing technology enable high-throughput clonality analysis via vector integration site (VIS) sequencing, which is particularly useful for studying complex polyclonal hematopoietic progenitor/stem cell (HPSC) repopulation. However, clonal repopulation analysis using the current methods is typically semiq

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Güney, Ertuğrul, and Mehmet Döker. "Assessment of black ice risk levels in the city center of Erzurum (Turkey) using geospatial data." Journal of the Geographical Institute Jovan Cvijic, SASA, no. 00 (2025): 1. https://doi.org/10.2298/ijgi241028001g.

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Severe winter conditions, including extended snow cover and frequent frosty days, increase the risk of traffic accidents due to icing, leading to more accidents, even with injuries and fatalities. Erzurum (Eastern Anatolia Region, Turkey), with its harsh winters, stands out as a city requiring attention in this regard. The study focused on Erzurum city center, where the combination of winter weather conditions (October-April) and high traffic volume heightened the accident risk from icing in the period 2017-2022. Accident data from the General Directorate of Security of the Republic of Turkey

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Yahiaoui, K., D. N. Moreton, and D. G. Moffat. "Response and Damping of Fabricated Branch Pipe Junctions Subjected to Internal Pressure and Simulated Seismic Bending." Journal of Pressure Vessel Technology 117, no. 2 (1995): 156–61. http://dx.doi.org/10.1115/1.2842104.

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This paper presents some of the results obtained from fifteen tests performed to investigate the ratcheting behavior of fabricated piping branch junctions subjected to steady internal pressure and dynamic resonant run pipe in-plane bending imposed to simulate seismic events. The experimental evidence confirms that the dynamic stresses are self-limiting, and thus secondary in nature. The logarithmic decrement method is used to estimate the percentage damping ratios from the steadily decaying free vibration data at the end of a forcing event. It is demonstrated that the percentage damping, measu

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Balmer, Lois, Caroline Ann O’Leary, Marilyn Menotti-Raymond, et al. "Mapping of Diabetes Susceptibility Loci in a Domestic Cat Breed with an Unusually High Incidence of Diabetes Mellitus." Genes 11, no. 11 (2020): 1369. http://dx.doi.org/10.3390/genes11111369.

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Genetic variants that are associated with susceptibility to type 2 diabetes (T2D) are important for identification of individuals at risk and can provide insights into the molecular basis of disease. Analysis of T2D in domestic animals provides both the opportunity to improve veterinary management and breeding programs as well as to identify novel T2D risk genes. Australian-bred Burmese (ABB) cats have a 4-fold increased incidence of type 2 diabetes (T2D) compared to Burmese cats bred in the United States. This is likely attributable to a genetic founder effect. We investigated this by perform

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Feng, Jinyong, Tarek Frahi, and Emilio Baglietto. "STRUCTure-based URANS simulations of thermal mixing in T-junctions." Nuclear Engineering and Design 340 (December 2018): 275–99. http://dx.doi.org/10.1016/j.nucengdes.2018.10.002.

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Hart, J., P. J. Hamersma, and J. M. H. Fortuin. "Phase distribution during gas—liquid flow through horizontal dividing junctions." Nuclear Engineering and Design 126, no. 3 (1991): 293–312. http://dx.doi.org/10.1016/0029-5493(91)90022-a.

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Mullen, Craig A., Sana Usmani, Leti Nunez, and Olena Tkachenko. "Efficient Delivery of Antiapoptotic Signals from Marrow Stromal Cells to Acute Lymphoblastic Leukemia Cells Is Associated with Differential Expression of Genes Related to the Membrane and to Regulation of Apoptosis and Is Dependent in Part on Gap Junction Function." Blood 128, no. 22 (2016): 5066. http://dx.doi.org/10.1182/blood.v128.22.5066.5066.

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Abstract Nonmalignant marrow stroma provides a favorable microenvironment for leukemia cell survival. The mechanisms of support are not well understood. Some studies have identified roles for some stromal derived molecules including some growth factors (EGF, FGF, PDGF), adhesion molecules (VCAM, selectins, osteopontins, integrins, fibronectin), cytokines (IL3, IL6, IL7) and others (KITLG, ANGPT1, CXCL12, LGALS3). It is clearly a multifactorial mechanism. We have developed a simple but powerful experimental system of human marrow derived stromal cells co-cultured with primary human high risk AL

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_, _. "Esophageal Cancer." Journal of the National Comprehensive Cancer Network 6, no. 9 (2008): 818. http://dx.doi.org/10.6004/jnccn.2008.0062.

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Upper gastrointestinal (GI) tract cancers originating in the esophagus, gastroesophageal (GE) junctions, and stomach constitute a major health problem worldwide; esophageal cancer is the eighth most common cancer worldwide. An estimated 16,470 new cases of and 14,280 deaths from esophageal cancer will occur in the United States in 2008. Risk factors associated with development of esophageal cancer include age, male gender, Caucasian race, high body mass index, Barrett's esophagus, and history of gastroesophageal reflux disease. Important updates for the 2009 guidelines include a new page on “P

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Salahi, A., W. A. Abd El-Ghany, Y. A. Attia, N. M. Zabermawi, F. Bovera, and V. Tufarelli. "Gut dysbiosis: Nutritional causes and risk prevention in poultry, with reference to other animals." South African Journal of Animal Science 55, no. 2 (2025): 32–63. https://doi.org/10.4314/sajas.v55i2.01.

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The poultry gastrointestinal microbiome consists of more than 900 bacterial species and their metabolites; it serves as an indicator of bird health and is influenced by nutrition, medication, and other factors. Dysbiosis is a form of reduced microbial diversity, characterised by the loss of beneficial microbes, the expansion of opportunistic microbes, and the disruption of tight junctions, as well as raised pro-inflammatory cytokines (interleukin-6 and interleukin-17), tumour necrosis factor-α, and Enterobacteriaceae, and decreased short-chain fatty acids. Dysbiosis leads to various disorders,

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Nedzvetsky, V. S., D. M. Masiuk, V. Y. Gasso, S. V. Yermolenko, A. O. Huslystyi, and V. A. Spirina. "Low doses of imidacloprid induce disruption of intercellular adhesion and initiate proinflammatory changes in Caco-2 cells." Regulatory Mechanisms in Biosystems 12, no. 3 (2021): 430–37. http://dx.doi.org/10.15421/022159.

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Imidacloprid is the most widely used pesticide of the neonicotinoid class. Neonicotinoid toxicities against various insects are well known. Nevertheless, there are rising evidences that neonicotinoids exert cytotoxic effects on different non-target organisms including mammals, fish, birds etc. Besides, depending on pesticide application, the exposed plants absorb some part of used neonicotinoids and their residues are detected in agricultural products worldwide. Thus, the continuous consumption of fruits and vegetables contaminated with neonicotinoids is a high risk factor for humans despite t

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Xuan, Fu-Zhen, Pei-Ning Li, and Shan-Tung Tu. "Plastic limit load of welded piping branch junctions under internal pressure." Nuclear Engineering and Design 224, no. 1 (2003): 1–9. http://dx.doi.org/10.1016/s0029-5493(03)00075-x.

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Johnsson, D., M. Mayerhofer, J. Willemen, et al. "Avalanche Breakdown Delay in High-Voltage p-n Junctions Caused by Pre-Pulse Voltage From IEC 61000-4-2 ESD Generators." IEEE Transactions on Device and Materials Reliability 9, no. 3 (2009): 412–18. http://dx.doi.org/10.1109/tdmr.2009.2023513.

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Zhu, Jiyue, Xiang Zhu, Tingting Su, Huiqing Zhou, Shouhua Wang, and Weibin Shi. "The Development and Assessment of a Unique Disulfidptosis-Associated lncRNA Profile for Immune Microenvironment Prediction and Personalized Therapy in Gastric Adenocarcinoma." Biomedicines 13, no. 5 (2025): 1224. https://doi.org/10.3390/biomedicines13051224.

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Background: Long non-coding RNAs (lncRNAs) are crucial factors affecting the occurrence, progression, and prognosis of gastric carcinoma (GC). The accumulation of disulfide bonds to excessive levels in cells expressing high SLC7A11 triggers disulfidptosis, which functions as a regulated form of cellular death. Research has demonstrated that upregulated SLC7A11 is common in human cancers, but the effect of disulfidptosis on GC remains unclear. Identifying lncRNAs associated with disulfidptosis (drlncRNAs) and establishing a prognostic risk profile holds considerable importance for advancing GC

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Meyer, N. K., W. Schwanghart, O. Korup, and F. Nadim. "Roads at risk: traffic detours from debris flows in southern Norway." Natural Hazards and Earth System Sciences 15, no. 5 (2015): 985–95. http://dx.doi.org/10.5194/nhess-15-985-2015.

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Abstract. Globalisation and interregional exchange of people, goods, and services has boosted the importance of and reliance on all kinds of transport networks. The linear structure of road networks is especially sensitive to natural hazards. In southern Norway, steep topography and extreme weather events promote frequent traffic disruption caused by debris flows. Topographic susceptibility and trigger frequency maps serve as input into a hazard appraisal at the scale of first-order catchments to quantify the impact of debris flows on the road network in terms of a failure likelihood of each l

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Meyer, N. K., W. Schwanghart, O. Korup, and F. Nadim. "Roads at risk – traffic detours from debris flows in southern Norway." Natural Hazards and Earth System Sciences Discussions 2, no. 10 (2014): 6623–51. http://dx.doi.org/10.5194/nhessd-2-6623-2014.

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Abstract. Globalization and interregional exchange of people, goods, and services has boosted the importance of and reliance on all kinds of transport networks. The linear structure of road networks is especially sensitive to natural hazards. In southern Norway, steep topography and extreme weather events promote frequent traffic disruption caused by debris flows. Topographic susceptibility and trigger frequency maps serve as input into a hazard appraisal at the scale of first-order catchments to quantify the impact of debris flows on the road network in terms of a failure likelihood of each l

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Soekojo, Cinnie Yentia, Tae-Hoon Chung, Muhammad Shaheryar Furqan, and Wee-Joo Chng. "Identifying the Genomic Profile of Functional High-Risk Multiple Myeloma Patients." Blood 136, Supplement 1 (2020): 51–52. http://dx.doi.org/10.1182/blood-2020-136553.

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Background: Multiple myeloma (MM) patients with suboptimal response to induction therapy or early relapse, classified as the functional high-risk (FHR) patients, have been shown to have poor outcomes. However, the current risk stratification at diagnosis has not been able to accurately identify these patients. In clinical practice, we saw patients who were not identified as being high-risk at diagnosis having refractory disease or early relapse. The aim of our study is to evaluate the genomic profile of FHR MM patients at diagnosis. Method: We evaluated newly-diagnosed MM patients in the CoMMp

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Xuan, Fu-Zhen, and Pei-Ning Li. "Finite element-based limit load of piping branch junctions under combined loadings." Nuclear Engineering and Design 231, no. 2 (2004): 141–50. http://dx.doi.org/10.1016/j.nucengdes.2004.03.007.

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Selvam, P. Karthick, Rudi Kulenovic, Eckart Laurien, John Kickhofel, and Horst-Michael Prasser. "Thermal mixing of flows in horizontal T-junctions with low branch velocities." Nuclear Engineering and Design 322 (October 2017): 32–54. http://dx.doi.org/10.1016/j.nucengdes.2017.06.041.

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Hwang, In Tae, Gil Tae Kim, Jung Hyun Yoo, and Jong Sung Lee. "Improvement of the Korean Design Criteria on Wall-To-Wall Junctions to Prevent Condensation in Apartment Houses." Sustainability 11, no. 12 (2019): 3272. http://dx.doi.org/10.3390/su11123272.

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Maintaining a proper temperature and humidity in a living space is very important for the health and comfort of apartment residents. Poor residential thermal conditions are recognized as a potential risk to the overall physical health. Thus, building development criteria that maintain an indoor environment separate from the outside environment have been continuously strengthened. However, this has not been the case in Korea, with regards to design criteria for the prevention of indoor condensation. In Korea, condensation occurs indoors frequently, during the winter season. When the outside tem

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Wang, Shaohua, Bo Wang, Sidharth Mishra, et al. "A novel probiotics therapy for aging-related leaky gut and inflammation." Innovation in Aging 5, Supplement_1 (2021): 668–69. http://dx.doi.org/10.1093/geroni/igab046.2521.

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Abstract Inflammaging characterized with increased low grade inflammation in older adults is common determinant of unhealthy aging; and is a major risk factor of morbidity and mortality in older adults. The precise origin of inflammation in older adults is not known, however, emerging evidence indicate that increased intestinal epithelial permeability (leaky gut) and abnormal (dysbiotic) gut microbiota could be one of the key source. However, no preventive and treatment therapies are available to reverse the leaky gut and microbiome dysbiosis in older adults. Here, we presented the evidence th

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Ziółkowski, Robert. "Vehicles speed analysis in roundabouts vicinity." Budownictwo i Architektura 13, no. 4 (2014): 309–16. http://dx.doi.org/10.35784/bud-arch.1861.

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Driving speed is one of the most important factors in road safety as it not only affects the severity of a crash but it is also related to the risk of being involved in a crash. One of the solutions for improving safety in cities is to design new and replace already existing crossroads by roundabouts which offer improved safety over other types of intersections having fewer conflict points, slower speeds and easier decision making. Previously conducted studies considering traffic safety at crossroads in Bialystok have confirmed lower number of accidents and casualties at roundabouts when compa

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Zboray, Robert, and Horst-Michael Prasser. "On the relevance of low side flows for thermal loads in T-junctions." Nuclear Engineering and Design 241, no. 8 (2011): 2881–88. http://dx.doi.org/10.1016/j.nucengdes.2011.05.002.

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Chougule, V. A., J. B. Sapkale, and V. S. Pawar-Patil. "RUSLE and SDR model for erosional risk assessment and sediment yield estimation of Achara basin, western coast, India." Disaster Advances 14, no. 7 (2021): 19–31. http://dx.doi.org/10.25303/147da1921.

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The phenomenon of accelerated soil erosion, the resulting of irresponsible land use practices and human interference bring considerable changes within the Achara basin. The high rate of soil erosion deteriorates the fertility of the soil and consequently reduces crop productivity. Accumulation of transported soil at the lower part of the basin creates a severe problem of sedimentation within the channel and affects the hydraulic characteristics. The estimated potential sediment yield has been derived by using an integrated RUSLE model accompanied remote sensing database in geospatial environme

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Bunchorntavaku, Chalermrat l. "Acute liver failure." Thai Journal of Hepatology 1, no. 1 (2018): 1–13. http://dx.doi.org/10.30856/th.jhep2018vol1iss1_001.

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Acute liver failure (ALF) is a life threatening condition defined by the evidence of hepatic injury, jaundice, coagulopathy, and encephalopathy in a patient without preexisting cirrhosis and with an illness duration of <26 weeks. The etiologies of ALF are heterogeneous: viral hepatitis being the most common in the East, whereas drug-induced, particularly acetaminophen, being the most common in the West. Over the past decades, the outcomes of ALF have been improving with early recognition and prompt initiation of etiology-specific therapy (especially N-acetylcysteine), complex intensive care

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Bunchorntavakul, Chalermrat. "Acute liver failure." Thai Journal of Hepatology 1, no. 1 (2018): 1–13. http://dx.doi.org/10.30856/th.jhep2018vol1iss1_01.

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Acute liver failure (ALF) is a life threatening condition defined by the evidence of hepatic injury, jaundice, coagulopathy, and encephalopathy in a patient without preexisting cirrhosis and with an illness duration of <26 weeks. The etiologies of ALF are heterogeneous: viral hepatitis being the most common in the East, whereas drug-induced, particularly acetaminophen, being the most common in the West. Over the past decades, the outcomes of ALF have been improving with early recognition and prompt initiation of etiology-specific therapy (especially N-acetylcysteine), complex intensive care

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Urtishak, Karen A., Blaine W. Robinson, Jaclyn A. Biegel, Kim E. Nichols, Julie W. Stern, and Carolyn A. Felix. "Unique Familial MLL-rearranged Precursor B Cell Infant Acute Lymphoblastic Leukemia (ALL) in Non-Twin Siblings." Blood 118, no. 21 (2011): 2417. http://dx.doi.org/10.1182/blood.v118.21.2417.2417.

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Abstract Abstract 2417 Leukemia is the commonest malignancy in infants, the most frequently occurring form of which is infant ALL. When ALL occurs in infants the disease is clinically aggressive and associated with poor outcome. MLL gene rearrangements producing transforming fusion oncoproteins are found in 75% of infant ALL and they are adverse prognostic factors. Infant ALL has never occurred in families except in monozygous twins, where concordance in leukemia occurrence is nearly 100%. Identical but non-germline genomic breakpoint junction sequences have pointed to an in utero origin of ML

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