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Relevant bibliographies by topics / High-throughput compound screening

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Dissertations / Theses
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Academic literature on the topic 'High-throughput compound screening'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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Journal articles on the topic "High-throughput compound screening"

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Gosnell, Paul A., Amy D. Hilton, Lynette M. Anderson, Lyman Wilkins, and William P. Janzen. "Compound Library Management in High Throughput Screening." Journal of Biomolecular Screening 2, no. 2 (1997): 99–102. http://dx.doi.org/10.1177/108705719700200208.

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Compound library management is inherent to the success of a high throughput screen. The library management system developed at Sphinx Pharmaceuticals accomplishes this through a series of Paradox and Orade database applications. This suite of applications allows compounds to be grouped as libraries, inventoried, and scheduled for testing in a screen. Compound libraries can be defied using any combination of source, structure, and target, and may be divided into sublibraries, allowing a flexible mix of compounds to be scheduled across several targets. Test requests can then be made for an entir

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Entzeroth, Michael, Béatrice Chapelain, Jacques Guilbert, and Valérie Hamon. "High throughput drug profiling." Journal of Automated Methods and Management in Chemistry 22, no. 6 (2000): 171–73. http://dx.doi.org/10.1155/s1463924600000304.

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High throughput screening has significantly contributed to advances in drug discovery. The great increase in the number of samples screened has been accompanied by increases in costs and in the data required for the investigated compounds. High throughput profiling addresses the issues of compound selectivity and specificity. It combines conventional screening with data mining technologies to give a full set of data, enabling development candidates to be more fully compared.

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Astle, Thomas W. "MicroTape-A 384-Well Ultra High Throughput Screening System." JALA: Journal of the Association for Laboratory Automation 4, no. 2 (1999): 31–34. http://dx.doi.org/10.1177/221106829900400207.

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The use of a sprocket driven carrier tape provides a unique solution for Ultra High Throughput Screening. 10-microliter wells in the 384 well pattern are embossed in a polypropylene or polycarbonate carrier tape. For compound handling, 100,000 compounds in 5 microliter aliquots may be stored, sealed and frozen in a roll 16 inches in diameter and 4 inches wide. The sprocket drive provides recall to any given compound. At time of use, the peelable seal is removed for access to the compound aliquots. Two levels of assay automation are provided. In Phase I the compound MicroTape is used to support

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Hansen, Clinton H. "High-Throughput Compound Screening using DNA Nanoswitches." Biophysical Journal 110, no. 3 (2016): 653a. http://dx.doi.org/10.1016/j.bpj.2015.11.3496.

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YASGAR, A. "Compound Management for Quantitative High-Throughput Screening." Journal of the Association for Laboratory Automation 13, no. 2 (2008): 79–89. http://dx.doi.org/10.1016/j.jala.2007.12.004.

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Patel, Dhara A., Anand C. Patel, William C. Nolan, et al. "High-Throughput Screening Normalized to Biological Response." Journal of Biomolecular Screening 19, no. 1 (2013): 119–30. http://dx.doi.org/10.1177/1087057113496848.

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The process of conducting cell-based phenotypic screens can result in data sets from small libraries or portions of large libraries, making accurate hit picking from multiple data sets important for efficient drug discovery. Here, we describe a screen design and data analysis approach that allow for normalization not only between quadrants and plates but also between screens or batches in a robust, quantitative fashion, enabling hit selection from multiple data sets. We independently screened the MicroSource Spectrum and NCI Diversity Set II libraries using a cell-based phenotypic high-through

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Falk, Shaun P., Andrew T. Ulijasz, and Bernard Weisblum. "Differential Assay for High-Throughput Screening of Antibacterial Compounds." Journal of Biomolecular Screening 12, no. 8 (2007): 1102–8. http://dx.doi.org/10.1177/1087057107308161.

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The previously described Bacillus subtilis reporter strain BAU-102 is capable of detecting cell wall synthesis inhibitors that act at all stages of the cell wall synthesis pathway. In addition, this strain is capable of detecting compounds with hydrophobic/ surfactant activity and alternative mechanisms of cell wall disruption. BAU-102 sequesters preformed β-gal in the periplasm, suggesting leakage of β-gal as the means by which this assay detects compound activities. A model is proposed according to which β-gal release by BAU-102 reflects activation of pathways leading to autolysis. The autho

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Kondo, Mitsuyo, Makiko Kawamoto, Atsushi Hasuoka, Masahiro Kajino, Nobuhiro Inatomi, and Naoki Tarui. "High-Throughput Screening of Potassium-Competitive Acid Blockers." Journal of Biomolecular Screening 17, no. 2 (2011): 177–82. http://dx.doi.org/10.1177/1087057111421004.

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H+,K+-ATPase is a key enzyme in the process of gastric acid secretion, and proton pump inhibitors (PPIs) have been accepted as one of the most effective treatments for peptic ulcer and gastroesophageal reflux disease. To discover a novel class of PPIs, the authors screened a low-molecular-weight compound library and identified two prospective acid blockers that were pyrrole derivatives. Both compounds inhibited H+,K+-ATPase in a reversible and potassium-competitive manner. These compounds led to the development of TAK-438 (1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methyl

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Schmid, Ingrid, Isabel Sattler, Susanne Grabley, and Ralf Thiericke. "Natural Products in High Throughput Screening: Automated High-Quality Sample Preparation." Journal of Biomolecular Screening 4, no. 1 (1999): 15–25. http://dx.doi.org/10.1177/108705719900400104.

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At present, compound libraries from combinatorial chemistry are the major source for high throughput screening (HTS) programs in drug discovery. On the other hand, nature has been proven to be an outstanding source for new and innovative drugs. Secondary metabolites from plants, animals, and microorganisms show a striking structural diversity that supplements chemically synthesized compounds or libraries in drug discovery programs. Unfortunately, extracts from natural sources are usually complex mixtures of compounds, often generated in time-consuming and, for the most part, manual processes.

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Xia, Menghang, Ruili Huang, Kristine L. Witt, et al. "Compound Cytotoxicity Profiling Using Quantitative High-Throughput Screening." Environmental Health Perspectives 116, no. 3 (2008): 284–91. http://dx.doi.org/10.1289/ehp.10727.

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Dissertations / Theses on the topic "High-throughput compound screening"

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Brehm, Marius [Verfasser], and P. [Akademischer Betreuer] Levkin. "Miniaturized and Parallel Synthesis of Compound Libraries for High-Throughput On-Chip Screening on Hydrophilic-Hydrophobic Patterned Surfaces / Marius Brehm ; Betreuer: P. Levkin." Karlsruhe : KIT-Bibliothek, 2021. http://d-nb.info/123507241X/34.

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Hinrichs, Wilko [Verfasser], Klaus-Armin [Akademischer Betreuer] Nave, Martin [Akademischer Betreuer] Göpfert, André [Akademischer Betreuer] Fischer, and Moritz [Akademischer Betreuer] Rossner. "A cell-based NRG1-ERBB4 assay designed for high-throughput compound screening to identify small molecule modulators with relevance for schizophrenia / Wilko Hinrichs. Gutachter: Martin Göpfert ; André Fischer ; Moritz Rossner. Betreuer: Klaus-Armin Nave." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1044869100/34.

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Malo, Nathalie. "Statistical contributions to data analysis for high-throughput screening of chemical compounds." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102680.

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High-throughput Screening (HTS) is a relatively new process which allows several thousand chemical compounds to be tested rapidly in order to identify their potential as drug candidates. Despite increasing numbers of promising candidates, however, the numbers of new compounds that ultimately reach the market have declined. One way to improve upon this situation is to develop efficient and accurate data processing and statistical testing methods tailored for HTS. Human, biological or mechanical errors may develop across the several days it takes to run the entire screen and cause unwanted varia

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Barker, Samuel Peter. "Early stage drug discovery screening for novel compounds active against the persister phenotype in Burkholderia thailandensis." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/26236.

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Many pathogenic microorganisms are believed to stochastically switch into low metabolic states that display resistance to supra-lethal levels of antibiotics. These so-called “persister” cells have been associated with recurrent infections and the development of antibiotic resistance. Whilst a compound that eliminates Staphylococcus aureus persister cells has been described, it is not active against Gram-negative bacteria. The aim of my PhD project was to develop a high-throughput assay for compounds that eradicate persister cells in the -proteobacterium Burkholderia thailandensis. Further to

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Nishihara, Kana. "Identification of Genotoxic Compounds Using Isogenic DNA Repair Deficient DT40 Cell Lines on a Quantitative High Throughput Screening Platform." Kyoto University, 2016. http://hdl.handle.net/2433/215414.

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This is a pre-copyedited, author-produced PDF of an article accepted for publication in Mutagenesis following peer review. The definitive publisher-authenticated version is available online at:http://mutage.oxfordjournals.org/content/early/2015/08/03/mutage.gev055.full.<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第19588号<br>医博第4095号<br>新制||医||1014(附属図書館)<br>32624<br>京都大学大学院医学研究科医学専攻<br>(主査)教授小泉昭夫, 教授渡邊直樹, 教授高田穣<br>学位規則第4条第1項該当

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Shubbar, Ahmed. "Novel neuroprotective compounds for use in Parkinson's disease." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1384806955.

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Hoffmann, Hans-Heinrich [Verfasser]. "The identification of novel antivirals and enhancers of influenza virus replication via high-throughput screening of small molecular weight compounds / Hans-Heinrich Hoffmann." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025354036/34.

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Vazquez, Ana Carolina. "Identification and characterization of compounds with antiviral activity against influenza viruses." [Kent, Ohio] : Kent State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1227644336.

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Thesis (Ph.D.)--Kent State University, 2008.<br>Title from PDF t.p. (viewed Dec. 14, 2009) Advisor: Miguel E. Quinones-Mateu. Keywords: biomedical research, cellular biology, molecular biology, virology. Includes bibliographical references (p. 201-228)

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Aftab, Obaid. "Towards High-Throughput Phenotypic and Systemic Profiling of in vitro Growing Cell Populations using Label-Free Microscopy and Spectroscopy : Applications in Cancer Pharmacology." Doctoral thesis, Uppsala universitet, Cancerfarmakologi och beräkningsmedicin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-234565.

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Modern techniques like automated microscopy and spectroscopy now make it possible to study quantitatively, across multiple phenotypic and molecular parameters, how cell populations are affected by different treatments and/or environmental disturbances. As the technology development at the instrument level often is ahead of the data analytical tools and the scientific questions, there is a large and growing need for computational algorithms enabling desired data analysis. These algorithms must have capacity to extract and process quantitative dynamic information about how the cell population is

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Hsieh, Meng-Lun, and 謝孟倫. "Identification of small-molecule human PTGR-2 inhibitor through high-throughput compound screening." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/11717556324919987625.

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碩士<br>國立臺灣大學<br>基因體暨蛋白體醫學研究所<br>105<br>Peroxisome proliferator-activated receptor γ (PPARγ) is a master regulator of whole-body energy metabolism, glucose homeostasis, and insulin resistance mainly expressed in adipose tissue. PPARγ acts through transcriptional regulation of genes involved in glucose and energy homeostasis upon ligand binding. The widely used anti-diabetic agent thiazolidinediones (TZD) are potent synthetic PPARγ agonist. However, most PPARγ agonists are associated with significant side effects, such as water retention, increased adiposity, and osteoporosis. There is an urgent

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Book chapters on the topic "High-throughput compound screening"

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Conway, Michael, Ayla Annac, and Tetsuro Wakatsuki. "Three-dimensional engineered tissues for high-throughput compound screening." In Technology Platforms for 3D Cell Culture. John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781118851647.ch15.

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Petry, Stefan, Karl-Heinz Baringhaus, Karl Schoenafinger, Christian Jung, Horst Kleine, and Günter Müller. "High-throughput Screening of Hormone-sensitive Lipase and Subsequent Computer-assisted Compound Optimization." In Lipases and Phospholipases in Drug Development. Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527601910.ch7.

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Kwanten, Leen, Ben De Clerck, and Dirk Roymans. "A Fluorescence-Based High-Throughput Antiviral Compound Screening Assay Against Respiratory Syncytial Virus." In Antiviral Methods and Protocols. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-484-5_26.

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Kiefer, Jeff, Hongwei H. Yin, Qiang Q. Que, and Spyro Mousses. "High-Throughput siRNA Screening as a Method of Perturbation of Biological Systems and Identification of Targeted Pathways Coupled with Compound Screening." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-175-2_15.

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Halder, Vivek, and Erich Kombrink. "High-Throughput Screening of Chemical Compound Libraries for Modulators of Salicylic Acid Signaling by In Situ Monitoring of Glucuronidase-Based Reporter Gene Expression." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7874-8_5.

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van Vugt-Lussenburg, Barbara, Harrie T. Besselink, Bart van der Burg, and Abraham Brouwer. "Dr-Calux®: A High-Throughput Screening Assay for the Detection of Dioxin and Dioxin-Like Compounds in Food and Feed." In High-Throughput Screening Methods in Toxicity Testing. John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118538203.ch29.

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Eremin, Sergey. "Immunochemical methods for detection of organophosphorus compounds." In ORGANOPHOSPHORUS NEUROTOXINS. Publishing Center RIOR, 2020. http://dx.doi.org/10.29039/33_219-230.

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Organophosphorus compounds (OP) are found in environmental objects and food products. Due to their high toxicity and inhibition of cholinesterase activity, it is necessary to control residual amounts of OP. The most common methods for determining OP are gas and liquid chromatography with various detection methods. However, chromatographic analysis is lengthy, requires complex sample preparation and expensive equipment, which limits its use for screening a large number of samples and continuous monitoring of the content of OP. To detect the OP, it is necessary to use High Throughput Screening methods, using simple, fast and inexpensive analysis methods. Currently, immunochemical methods are increasingly used to determine OP. These methods are based on the recognition of the analyte (antigen) by specific receptors (antibodies) with the formation of the antigen-antibody complex and the measurement of the analytical signal generated by the immunochemical test system in response to complex formation, which leads to high sensitivity and specificity of the analysis.

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Wong, Catherine C. K., and Yung Hou Wong. "High-Throughput Screening in Traditional Chinese Medicine-Based Drug Discovery." In Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6214-5_26.

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Pedemonte, Nicoletta, Olga Zegarra-Moran, and Luis J. V. Galietta. "High-Throughput Screening of Libraries of Compounds to Identify CFTR Modulators." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-117-8_2.

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Barradas, Marta, Wolfgang Link, Diego Megias, and Pablo J. Fernandez-Marcos. "High-Throughput Image-Based Screening to Identify Chemical Compounds Capable of Activating FOXO." In FOXO Transcription Factors. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8900-3_13.

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Conference papers on the topic "High-throughput compound screening"

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Kirkbride, Kellye C., Kevin J. Polach, Samantha J. Braxton, et al. "Abstract 294: ChemoINTEL: A high-throughput, multi-parametric compound screening platform for intelligent lead compound and therapeutic combination identification." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-294.

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Kirkbride, Kellye C., Kevin J. Polach, Samantha J. Braxton, et al. "Abstract 294: ChemoINTEL: A high-throughput, multi-parametric compound screening platform for intelligent lead compound and therapeutic combination identification." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-294.

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Swift, Kerry M., and Edmund D. Matayoshi. "Evaluation of a red fluorescent dye for high-throughput compound screening applications in pharmaceutical discovery research." In BiOS '99 International Biomedical Optics Symposium, edited by Joseph R. Lakowicz, Steven A. Soper, and Richard B. Thompson. SPIE, 1999. http://dx.doi.org/10.1117/12.347522.

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Fei, Y. Y., J. P. Landry, Y. S. Sun, et al. "Label-free screening small-molecule compound libraries for protein-ligands using a high-throughput optical scanning microscope." In SPIE BiOS: Biomedical Optics, edited by Daniel L. Farkas, Dan V. Nicolau, and Robert C. Leif. SPIE, 2009. http://dx.doi.org/10.1117/12.809700.

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Landry, J. P., Y. Y. Fei, Y. S. Sun, J. T. Luo, K. S. Lam, and X. D. Zhu. "Label-Free Screening of Protein Binding to Small Molecule Compound Microarrays with A High-Throughput Optical Scanning Microscope." In Frontiers in Optics. OSA, 2009. http://dx.doi.org/10.1364/fio.2009.ftuy4.

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Hong Zhao, Kemi Cui, Patrick Smollen, and Stephen TC Wong. "A high-throughput multi-scale assay for anti-migration compound screening by bioluminescence imaging: From in vitro to in vivo." In 2007 IEEE/NIH Life Science Systems and Applications Workshop. IEEE, 2007. http://dx.doi.org/10.1109/lssa.2007.4400899.

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OGrady, Mike, Leticia A. Montoya, Michelle Yan, et al. "Abstract 3643: Flow cytometry multiplexing used to analyze metabolic activity and assess pharmaceutical compound toxicity as a high throughput screening tool." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-3643.

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Bingham, Patrick J., Karen Maegley, and Cody T. Krivacic. "Abstract 5155: RapidFire MS/MS enables both rapid evaluation of multiple histone methyltransferases and label-free high throughput screening of targeted compound libraries." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-5155.

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Minogue, Edel M., George J. Havrilla, Tammy P. Taylor, Anthony K. Burrell, and Benjamin P. Warner. "High-throughput screening of metal chelating compounds." In Biomedical Optics 2005, edited by Dan V. Nicolau, Joerg Enderlein, Robert C. Leif, Daniel L. Farkas, and Ramesh Raghavachari. SPIE, 2005. http://dx.doi.org/10.1117/12.601911.

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Villeneuve, Nicole F., Yu Du, Xiao-Jun Wang, Zheng Sun, and Donna D. Zhang. "High-throughput screening of chemopreventive compounds targeting Nrf2." In 2008 3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems. IEEE, 2008. http://dx.doi.org/10.1109/nems.2008.4484518.

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Reports on the topic "High-throughput compound screening"

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Caughey, Byron, and David Kocisko. High-Throughput Screening of Compounds for Anti-Transmissible Spongiform Encephalopathy Activity Using Cell-Culture and Cell-Free Models and Infected Animals. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada475121.

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