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Relevant bibliographies by topics / Higher in vivo antiplasmodial activities

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Academic literature on the topic 'Higher in vivo antiplasmodial activities'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Higher in vivo antiplasmodial activities"

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Kidima, Winifrida, Rebecca Wambura, Vitus Nyigo, Shabban Katani, and Hamisi Malebo. "Synergy and Antagonism in Antimalarial Crude Extract Combinations." Tanzania Journal of Health Research 25, no. 2 (2024): 934–46. http://dx.doi.org/10.4314/thrb.v25i2.17.

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Background Malaria accounts for around 4.8% of all recorded fatalities in Tanzania. Medicinal plants such as Caesalpinia bonducella, Azadirachta indica, and Annickia kummeriae have demonstrated promise in treating many diseases, including malaria. However, their combined activity against malaria has not been documented. Combination therapy using some medicinal plants with antimalarial activities may enhance safety and efficacy and reduce the evolution of parasite resistance. Objectives This study aimed to investigate antiplasmodium activities of different combinations of crude extracts from se

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Kuranen, Fabian, Charles Nnadi, and Matthias Agbo. "Antiplasmodial and cytotoxic activities of Jussiaea linifolia G. Don extracts." Tropical Journal of Pharmaceutical Research 23, no. 12 (2025): 2043–52. https://doi.org/10.4314/tjpr.v23i12.9.

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Purpose: To evaluate the in vivo and in vitro antiplasmodial activity of Jussiaea linifolia extracts using validated models.Methods: Methanol extract was partitioned into n-hexane, ethyl acetate and n-butanol fractions and subjected to antiplasmodial and cytotoxic activity assays. The in vivo assay adopted Peter’s four-day suppressive and Ranes curative tests to estimate Plasmodium berghei NK47 growth suppression while the in vitro antiplasmodial activities were performed using chloroquine-sensitive Plasmodium falciparumNF54 and L6 mammalian myoblast to determine growth inhibition and cytotoxi

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Chhour, Monivan, Agnès Aubouy, Sandra Bourgeade-Delmas, et al. "Antimalarial Properties of Dunnione Derivatives as NQO2 Substrates." Molecules 24, no. 20 (2019): 3697. http://dx.doi.org/10.3390/molecules24203697.

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Dunnione, a natural product isolated from the leaves of Streptocarpus dunnii (Gesneriaceae), acts as a substrate for quinone-reductases that may be associated with its antimalarial properties. Following our exploration of reactive oxygen species-producing compounds such as indolones, as possible new approaches for the research of new ways to treat this parasitosis, we explored derivatives of this natural product and their possible antiplasmodial and antimalarial properties, in vitro and in vivo, respectively. Apart from one compound, all the products tested had weak to moderate antiplasmodial

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Nadia, Noumedem Anangmo Christelle, Yamssi Cédric, Ngongang Ouankou Christian, et al. "In Vivo Antiplasmodial Activity of Entandrophragma cylindricum (Sprague) Sprague Ethyl Acetate Extract in Plasmodium berghei-Infected Mice." Journal of Parasitology Research 2020 (November 13, 2020): 1–7. http://dx.doi.org/10.1155/2020/8846067.

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Background. One of the most dangerous Plasmodium species is Plasmodium falciparum. Hence, it causes a higher rate of mortality. The resistance of Plasmodium falciparum to the ACT (Artemisinin-based Combination Therapies) has led to the search for new antimalarial drugs. The purpose of this research was to assess the in vivo antiplasmodial activity of Entandrophragma cylindricum ethyl acetate extract to provide a scientific basis for the use of this medicinal plant to treat malaria. Methods. Entandrophragma cylindricum stem bark powder was macerated in ethyl acetate to obtain the extract. The e

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Olanlokun, John Oludele, Janet Adenike Adetutu, and Olabode Olufunso Olorunsogo. "ln vitro inhibition of beta-hematin formation and in vivo effects of Diospyros mespiliformis and Mondia whitei methanol extracts on chloroquine-susceptible Plasmodium berghei-induced malaria in mice." Interventional Medicine and Applied Science 11, no. 4 (2021): 197–206. http://dx.doi.org/10.1556/1646.2020.00001.

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AbstractBackground and aimThis study was carried out to investigate antiplasmodial activities of Diospyros mespiliformis (DM) and Mondia whitei (MW) in Plasmodium berghei-infected mice.Materials and methodsAir-dried stem of DM and root of MW were soaked in methanol, decanted and concentrated to give extracts. Parts of these extracts were partitioned successively to give dichloromethane, ethylacetate and methanol fractions. Mice (18 ± 3 g) were infected with Plasmodium berghei-infected erythrocytes from a donor mouse and were treated with the extracts, while the drug control group received 10 m

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Koech, Joan C., M. Ngeiywa, J. Makwali, J. Gathirwa, F. Kimani, and E. Kigondu. "<i>In Vitro</i> Antiplasmodial Activities and Safety of <i>Ocimum gratissimum</i> L and <i>Rhoicissus tridentate</i> L. F Inorganic and Organic Solvents Extracts." Journal of Medical Science, Biology, and Chemistry 2, no. 1 (2025): 21–31. https://doi.org/10.69739/jmsbc.v2i1.230.

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This study evaluated Ocimum gratissimum and Rhoicissus tridentata for their In vitro antimalarial activity and safety. The plant samples collected from Keiyo South in Kenya were processed and their compounds were extracted using inorganic and organic solvents. Phytochemical screening, antiplasmodial bioassays, cytotoxicity tests, and statistical analyses were conducted to validate and compare the efficacies of the two plant used traditionally in treatment of malaria in Kenya. O. gratissimum extracts showed strong inhibition and low toxicity, with methanol as the most effective solvent. Methano

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AKOSILE, Oluwayomi Rebecca, Samuel Akintunde Odediran, Rachael Adebola BAMIGBOYE, Praise Adetola ADEBAYO та Deborah Abimbola ADEBOLU. "ANTIPLASMODIAL AND Β-HEMATIN INHIBITORY POTENTIAL OF THE EXTRACT AND SOLVENT FRACTIONS OF NEPHROLEPIS UNDULATA". African Journal of Traditional, Complementary and Alternative Medicines 20, № 1 (2024): 8–20. https://doi.org/10.21010/ajtcamv20n1.2.

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Background: The beta-hematin-inhibitory potential of the extract and the partitioned fractions of Nephrolepis undulata have not been determined, neither the likely constituents responsible for the observed in vivo antiplasmodial activities identified, hence this study. Materials and Methods: The methanol extract of N. undulata (MNU), was evaporated in vacuo and subsequently partitioned to give HNU (n hexane), DNU (dichloromethane), ENU (ethyl acetate) and ANU (aqueous phase) which were investigated in vivo in mice at 0-800mg/kg against chloroquine-sensitive Plasmodium berghei berghei using Pet

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Nyandwaro, Kevin, Job Oyweri, Francis Kimani, and Amos Mbugua. "Evaluating Antiplasmodial and Antimalarial Activities of Soybean (Glycine max) Seed Extracts on P. falciparum Parasite Cultures and P. berghei-Infected Mice." Journal of Pathogens 2020 (February 18, 2020): 1–8. http://dx.doi.org/10.1155/2020/7605730.

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Background. Plasmodium parasite resistance to artemisinin-based combination therapies (ACTs) calls for development of new, affordable, safe, and effective antimalarial drugs. Studies conducted previously on soybean extracts have established that they possess antimicrobial, anti-inflammatory, anticancerous, and antioxidant properties. The activity of such extracts on Plasmodium parasites has not been potentially exploited. Objectives. The aim of this study was to determine the antiplasmodial activity of soybean extracts using Plasmodium falciparum cultures, followed by an in vivo evaluation of

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AKOSILE, Oluwayomi Rebecca, Samuel Akintunde Odediran, Rachael Adebola BAMIGBOYE, Praise Adetola ADEBAYO та Deborah Abimbola ADEBOLU. "The ANTIPLASMODIAL AND Β-HEMATIN INHIBITORY POTENTIAL OF THE EXTRACT AND SOLVENT FRACTIONS OF NEPHROLEPIS UNDULATA". African Journal of Traditional, Complementary and Alternative Medicines 20, № 1 (2025): 8–20. https://doi.org/10.21010/ajtcamv20i1.2.

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Background: The beta-hematin-inhibitory potential of the extract and the partitioned fractions of Nephrolepis undulata have not been determined, neither the likely constituents responsible for the observed in vivo antiplasmodial activities identified, hence this study. Materials and Methods: The methanol extract of N. undulata (MNU), was evaporated in vacuo and subsequently partitioned to give HNU (n hexane), DNU (dichloromethane), ENU (ethyl acetate) and ANU (aqueous phase) which were investigated in vivo in mice at 0-800mg/kg against chloroquine-sensitive Plasmodium berghei berghei using Pet

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Sulaiman Ayodeji Apampa and David Adeniran Adedapo. "Phytochemical investigation, in-vitro antiplasmodial assessment and cytotoxic effect of ethanol extract of whole plant of Crotalaria arenaria (Benth)." International Journal of Biological and Pharmaceutical Sciences Archive 7, no. 2 (2024): 013–23. http://dx.doi.org/10.53771/ijbpsa.2024.7.2.0033.

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Crotataria arenaria (Benth) is a native plant from Northern part of Nigeria which is employed as antimalarial herb in traditional medicine in the communities where it grows. The phytochemical composition, In-vitro antiplasmodial activity and in-vitro cytotoxic effect of the extract and fractions of the whole plant of Crotalaria arenaria were investigated. The mature and fresh whole plant of C. arenaria were collected, air dried and pulverized. The pulverized form of the plant were soaked in ethanol for two weeks and later decanted, filtered and concentrated using rotatory evaporator at 40oC an

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Book chapters on the topic "Higher in vivo antiplasmodial activities"

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Douce, Roland. "Mitochondrial Oxidative Activities in Relation to in Vivo Metabolism." In Mitochondria in Higher Plants. Elsevier, 1985. http://dx.doi.org/10.1016/b978-0-12-221280-2.50010-x.

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Snijders Chris J., Molenbroek Johan F.M., and Plante Rozemarijn A. "Biomechanical Aspects of Defecation with Implications for the Height of the Toilet." In Assistive Technology Research Series. IOS Press, 2011. https://doi.org/10.3233/978-1-60750-752-9-207.

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Study Design: Questionnaire on impairments, biomechanics of posture and anthropometrics of seating height. Objective: To question the suitability of a higher toilet for the elderly. Methods: The first study is a verbal inquiry held among fourteen elderly of which twelve were living independently in a care institute and two needed help for daily activities. This chapter is a selection of aspects related to toilet height. The second study deals with biomechanics of pelvic floor geometry in relation to sitting posture with in vitro and in vivo measurements. The third study was an analysis of anth

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Dhiman, Sukhvinder, Gulshan Kumar, Ajay Kumar, Sapna Devi, Sonika, and Manoj Kumar. "Anthraquinones as Bioactive Agents: Recent Trends and Developments in Phytotherapy." In Anthraquinones: Bioactive Multifaceted Therapeutic Agents. BENTHAM SCIENCE PUBLISHERS, 2025. https://doi.org/10.2174/9789815313987125030006.

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Anthraquinones are organic compounds and members of the Quinone family comprising 9, 10-anthracenedione core. Anthraquinone is a chemical scaffold that has been employed for many years in a variety of therapeutic applications such as antimicrobial, anticancer, diuretic, anti-inflammatory, and phytoestrogen activities. Anthraquinones are commonly produced as secondary metabolites in various higher plant species (senna, buckthorn, yellow dock) or they can either be synthesized using chemical routes such as the condensation of 1, 4-naphthoquinone with butadiene, naphthalene oxidation, anthracene

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Li, Xiaohan, and Bing Hu. "Improvement of Oleanolic Acid Production in Saccharomyces Cerevisiae Based on OptKnock Framework." In Studies in Health Technology and Informatics. IOS Press, 2023. http://dx.doi.org/10.3233/shti230831.

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Biosynthesis of plant-derived natural products in the eukaryotic microbe Saccharomyces cerevisiae often faces the issue of the inefficient production due to the poor compatibility between the heterologous genes and chassis cells. In order to improve the biosynthetic efficiency of heterologous production of plant secondary metabolites in S. cerevisiae, people usually do metabolic engineering in and around the heterologous metabolic pathways based on researchers’ experience and mass of trials, which usually consumes a lot of manpower and financial resources. Herein, to further improve the hetero

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Conference papers on the topic "Higher in vivo antiplasmodial activities"

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Patwardhan, Avinash, Robert Havey, Kevin Meade, Brian Lee, Brian Dunlap, and Thomas Gavin. "Stability of the Lumbar Spine Subjected to a Follower Load: Part I — Experimental Results." In ASME 1998 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/imece1998-0087.

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Abstract Compression on the lumbar spine is estimated to reach 1000 N during standing and walking activities and is higher during lifting (McGill, 1990). Ex vivo experiments show it buckles at approximately 80–100 N (Crisco and Panjabi, 1992). Differences between maximum ex vivo and in vivo loads have not been satisfactorily explained. Many studies agree that muscles stabilize the spine. However, there is no agreement on the mechanism of stabilization.

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Papaioannou, George, William Anderst, and Scott Tashman. "Elevated Joint Contact Forces in ACL-Reconstructed Knees: A Finite Element Analysis Driven by In Vivo Kinematic Data." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43067.

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Assessment of in vivo human cartilage loading generally requires computer modeling, since loads usually cannot be directly measured. The utility of these models for assessing knee behavior during complex activities has been limited by the relatively poor quality of experimental data on in vivo knee function. We have developed a method combining high-accuracy knee kinematics (from high-speed stereo-radiography) with subject-specific finite-element models to estimate in vivo cartilage contact pressures during stressful tasks. When applied to ACL reconstruction, significantly higher contact press

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ten Cate, H., Ch P. HENNY, A. Sturk, A. Prins, and J. W. ten Cate. "COMPARATIVE INVESTIGATION OF CLOTTING AND CHROMOGENIC ASSAYS FOR HEPARIN AND LOW MOLECULAR WEIGHT HEPARIN-(OID) IN PLASMA OF VOLUNTEERS AND PATIENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644166.

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Two recently developed and simplified anti-Xa methods, a chromogenic assay and a clot-based assay (Heptest) were investigated on their accuracy and ex-vivo characteristics. The coefficients of variation (c.v.) for heparin, a heparin fragment (K 2165) and a LMW hepa-rinoid (Org 10172) were respectively: Heptest, within assay c.v.: 5.4; 4.5; 5.0 % between-assay c.v.: 7.8; 5.8; 9.5 %. Chromogenic Anti-Xa assay, within assay c.v.: 3.7; 5.6; 4.6 %, between assay c.v.: 6.6; 8.2; 12.1 %. In plasma samples obtained from volunteers and patients who participated in clinical studies using heparin, K 2165

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Norm, R., J. Fareed, I. Silber, A. Belo, R. Fenchel, and R. McGuire. "SUBCUTANEOUS PHARMACOKINETICS/PHARMACODYNAMICS OF A LOW MOLECULAR WEIGHT DERIVATIVE (RD 11885) AND UNFRACTIONATED HEPARIN (PM 16885) IN PRIMATES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644174.

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Subcutaneous pharmacokinetics/pharmacodynamics of a depolymerized low molecular weight heparin (RD 11885) and an unfractionated porcine mucosal heparin (PM 16885) were studied in primates (Macaca mulatta) at 0.5, 1.0 and 2.5 mg/kg/24 hr for 10 days after repeated administration. Ex vivo actions were determined using partial thromboplastin time (APTT), thrombin time (TT), IieptestR time (HT) , anti-factor Xa and anti-factor Ila assays at various time periods. Platelet counts and bleeding times were also measured. The cumulative bioavailability of RD 11885 calculated ex vivo was found to be 2-3

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Henak, Corinne R., Eric D. Carruth, Andrew E. Anderson, et al. "Finite Element Predictions of Cartilage Contact Mechanics in Hips With Retroverted Acetabula." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14125.

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Acetabular retroversion, defined by the crossover sign (COS) on plain film radiographs, (Figure 1) is thought to cause early onset osteoarthritis (OA). When the COS is present, the anterior acetabular rim is lateral to the posterior acetabular rim proximally. As the rim progresses distally, the posterior rim crosses lateral to the anterior rim, creating the COS. Clinical studies have demonstrated that hips with OA have a higher incidence of acetabular retroversion than normal hips [1–3]. There are two possible mechanical links between acetabular retroversion and OA. First, decreased area in th

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Hashimoto, Shigehiro, and Hiroki Yonezawa. "Tracings of Behavior of Myoblasts Cultured Under Couette Type of Shear Flow Between Parallel Disks." In ASME 2021 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/fedsm2021-65207.

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Abstract A cell deforms and migrates on the scaffold under mechanical stimuli in vivo. In this study, a cell with division during shear stress stimulation has been observed in vitro. Before and after division, both migration and deformation of each cell were analyzed. To make a Couette-type shear flow, the medium was sandwiched between parallel disks (the lower stationary culture-disc and the upper rotating disk) with a constant gap. The wall shear stress (1.5 Pa &lt; τ &lt; 2 Pa) on the surface of the lower culture plate was controlled by the rotational speed of the upper disc. Myobla

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Qin, Y. X., M. Hu, F. Serra-Hsu, et al. "Local and Distant Intramedullary Pressure and Bone Strain by Dynamic Hydraulic Stimulation." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-54017.

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Osteoporosis gives rise to fragile bones that have higher fracture risks due to diminished bone mass and altered bone microarchitecture [1]. Mechanical loading mediated bone adaptation has demonstrated promising potentials as a non-pharmacological alteration for both osteogenic response and attenuation of osteopenia [2]. Intramedullary pressure (ImP) has been proposed as a key factor for fluid flow initiation and mechanotransductive signal inductions in bone. It is also suggested that integration of strain signals over time allows low-level mechanical strain in the skeleton to trigger osteogen

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Reports on the topic "Higher in vivo antiplasmodial activities"

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Stern, David B., and Gadi Schuster. Manipulation of Gene Expression in the Chloroplast: Control of mRNA Stability and Transcription Termination. United States Department of Agriculture, 1993. http://dx.doi.org/10.32747/1993.7568750.bard.

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Chloroplasts are the site of photosynthesis and of other essential biosynthetic activities in plant cells. Chloroplasts are semi-autonomous organelles, since they contain their own genomes and protein biosynthetic machinery, but depend on the coordinate expression of nuclear genes to assemble macromolecular complexes. The bioeingineering of plants requires manipulation of chloroplast gene expression, and thus a knowledge of the molecular mechanisms that modulate mRNA and protein production. In this proposal the heterotrophic green alga Chlamydomonas reinhardtii has been used as a model system

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