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Journal articles on the topic 'Higuchi And Connors'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Balakhonova, Olga Mikhailovna, Viktoriya Sergeevna Tyukova та Stanislav Anatolievich Kedik. "Evaluation of the phase solubility of inclusion complexes of diisopropylphenol (INN) with hydroxypropyl-β-cyclodextrin". Terapevt (General Physician), № 1 (1 січня 2021): 27–32. http://dx.doi.org/10.33920/med-12-2101-05.

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The paper presents the results of a study of the stability of aqueous solutions of inclusion complexes of hydroxypropyl-β-cyclodextrin with diisopropylphenol in various systems by the Higuchi-Connors phase solubility method. The phase solubility profiles for each system corresponding to the AN type are determined graphically, and the stability constants of the resulting inclusion complexes are calculated. An aqueous solution containing 0.2 % Tween 80 and 0.2 % mannitol was selected as the optimal condition for obtaining the hydroxypropyl-β-cyclodextrin inclusion complex with diisopropylphenol.

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2

Stepniak, Artur, Marta Biernacka, Magdalena Malecka, and Bartlomiej Palecz. "Host-Guest Complexes of Flavanone and 4′-Chloroflavanone with Naturals and Modified Cyclodextrin: A Calorimetric and Spectroscopy Investigations." Molecules 29, no. 13 (2024): 3123. http://dx.doi.org/10.3390/molecules29133123.

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The aim of the research was to investigate and compare the interaction between flavanones (flavanone, 4-chloro-flavanone) with potential anticancer activity and selected cyclodextrins. Measurements were made using calorimetric (ITC, DSC) and spectrophotometric (UV-Vis spectroscopy, FT-IR, 1H NMR) methods. The increase in the solubility in aqueous medium caused by the complexation process was determined by the Higuchi-Connors method. As a result of the study, the stoichiometry and thermodynamics of the complexation reaction were determined. The formation of stable inclusion complexes at a 1:1 M

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3

Chopade, Tanaji Abhiman Joshi Hrushikesh Anantrao. "PHASE SOLUBILITY STUDIES OF GLIMEPIRIDE WITH β-CYCLODEXTRIN AND HYDROXY PROPYL-β-CYCLODEXTRIN IN DIFFERENT pH". INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, № 09 (2017): 604–12. https://doi.org/10.5281/zenodo.1036514.

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An oral route of drug administration is most preferred rout of delivery, as it is convenient and ease of ingestion. One of the disadvantages of this rout is low bioavailability, as most of the drugs have poor solubility in water. In the case of poorly water-soluble drugs (BCS Class II and IV), dissolution is the rate-limiting step in the process of drug absorption. Cyclodextrins are widely used for to improve the physicochemical and pharmaceutical properties such as solubility, stability, and bioavailability of poorly soluble drug molecules. Glimepiride, is an antidiabetic drug, has poor solub

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4

Sandhan, Shallu, Kavita Sapra, and Jitender Mor. "Formulation and Evaluation of sustained release matrix tablets of Glipizide." Indian Journal of Pharmaceutical and Biological Research 1, no. 04 (2013): 89–94. http://dx.doi.org/10.30750/ijpbr.1.4.16.

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The aim of present investigation was to enhance the solubility of glipizide (BCS Class II). Glipizide is an oral antidiabetic agent with relatively short elimination half life. Inclusion complex of Glipizide with _-cyclodextrin was prepared by kneading method and evaluated for its in-vitro release. Phase solubility studies were performed according to method reported by Higuchi and Connors which was classified as AL type characterized by apparent 1:1 stability constant. The Glipizide and Beta Cyclodextrin found to be compatible which was observed from FTIR spectra of Glipizide _- CD Complex. Th

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5

Jagtap, Sneha, та Magdum Chandrakant. "Enhanced dissolution and solubility of Epalrestat with β-Cyclodextrin ternary complex using Arginine". Journal of Drug Delivery and Therapeutics 8, № 6 (2018): 62–67. http://dx.doi.org/10.22270/jddt.v8i6.2014.

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The objective of present is work to achieve improvement in solubility and dissolution using Epalrestat with β-cyclodextrin ternary complex with addition of L-arginine. Kneading method with and without incorporation of L-arginine was used to obtain the solid systems (binary and ternary complex) of Epalrestat with β-cyclodextrin and characterized for DSC, PXRD, SEM. Phase solubility, saturation solubility, dissolution and stability studies were carried out. The effect of L-arginine was investigated on complexation efficiency of β-cyclodextrin towards Epalrestat in an aqueous media through phase

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6

Matencio, Adrián, Samanta Hernández-García, Francisco García-Carmona, and José Manuel López-Nicolás. "A Way to Increase the Bioaccesibility and Photostability of Roflumilast, a COPD Treatment, by Cyclodextrin Monomers." Polymers 11, no. 5 (2019): 801. http://dx.doi.org/10.3390/polym11050801.

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Roflumilast is an orally available inhibitor of phosphodiesterase (PDE) type 4, which is widely used in chronic obstructive pulmonary diseases. However, it has low solubility and adverse effects include diarrhea and nausea. Since its solubilization may improve treatment and, dismissing any adverse effects, its interaction with cyclodextrins (CDs) was studied. The Higuchi-Connors method was used to determine the complexation constant with different CDs, pH values and temperatures. Molecular docking was used to predict interaction between the complexes. An in vitro digestion experiment was carri

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7

Kosecka-Judin, Ewa, Marek Wesolowski, and Dominik Paukszta. "Pattern recognition methods as supplementary techniques for identification of salicylamide — cyclodextrins inclusion complexes." Open Chemistry 10, no. 5 (2012): 1534–46. http://dx.doi.org/10.2478/s11532-012-0067-5.

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AbstractThe objective of this study was to learn whether or not the pattern recognition methods, such as agglomerative cluster analysis (CA) and principal component analysis (PCA), can be used as supplementary techniques for identification of salicylamide (SAA) inclusion complexes with β-cyclodextrin (β-CD) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). To do this, phase-solubility of SAA in the presence of the cyclodextrins was studied by the Higuchi-Connors method, which showed that the cyclodextrins enhanced the solubility of SAA in water as compared to that of the drug. Next, the solid phas

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8

Kaya, Ayşe, Basel Arafat, Havovi Chichger, et al. "Preparation and Characterisation of Zinc Diethyldithiocarbamate–Cyclodextrin Inclusion Complexes for Potential Lung Cancer Treatment." Pharmaceutics 16, no. 1 (2023): 65. http://dx.doi.org/10.3390/pharmaceutics16010065.

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Zinc diethyldithiocarbamate (Zn (DDC)2), a disulfiram metabolite (anti-alcoholism drug), has shown a strong anti-cancer activity in vitro. However, its application was limited by its low aqueous solubility and rapid metabolism. In this study, the solubility enhancement of Zn (DDC)2 is investigated by forming inclusion complexes with cyclodextrins. The inclusion complexes were prepared using two different types of beta-cyclodextrins, SBE-CD and HP-CD. Phase solubility diagrams for the resulting solutions were assessed; subsequently, the solutions were freeze-dried for further characterisation s

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9

Huremovic, Melita, Majda Srabovic, Mirsada Salihovic, and Ekrem Pehlic. "Inclusion Complex of Fexofenadine Hydrochloride with Cyclodextrins." Mediterranean Journal of Chemistry 11, no. 3 (2021): 282. http://dx.doi.org/10.13171/mjc02112181597huremovic.

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<p>Fexofenadine hydrochloride (FFN), (±)-4-[1-hydroxy-4[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butyl] α,α-dimethylbenzeneacetic acid hydrochloride, is a second-generation antihistamine that is used to treat allergies. The drug is highly hydrophobic and slightly soluble in water. Cyclodextrins are widely used to improve the physicochemical and pharmaceutical properties such as solubility, stability, and bioavailability of poorly soluble drug molecules.Cyclodextrins can molecularly encapsulate various drugs into their hydrophobic cavity without forming any covalent bonds. Cyclodextrin (C

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10

Kobrina, Larisa, Valentina Boyko, Halyna Hliieva, Sergii Riabov, Sergiy Rogalsky та Karolina Yanova. "PECULIARITIES OF COMPLEX FORMATION IN THE SULFOBUTYL ETHER-β-CYCLODEXTRIN - IONIC LIQUID SYSTEM". Ukrainian Chemistry Journal 88, № 1 (2022): 49–66. http://dx.doi.org/10.33609/2708-129x.88.01.2022.49-66.

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The inclusion complexation of sulfobutyl ether-β-cyclodextrin sodium salt (SBECD) - ionic liquid (IL) has been investigated by a series of appropriate methods. The stability constant of the complex of SBECD-IL (K = 72.4 m-1) was determined by the method of Higuchi and Connors. An increase in the surface tension of solutions with different SBECD’s content was recorded by using the method of Wilhelm's plate, which could serve as an additional evidence of the formation of inclusion complex between SBECD and IL. Analysis of the TGA results provided for the initial IL and SBECD, their mechanical mi

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11

Bessarabov, Volodymyr, Viktor Kostiuk, Viktoriia Lyzhniuk, et al. "Polymer solid dispersion system of nimesulide: in vitro dissolution assessment, thermodynamic and physicochemical characteristics." ScienceRise: Pharmaceutical Science, no. 1 (53) (February 28, 2025): 41–53. https://doi.org/10.15587/2519-4852.2025.322985.

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Nimesulide is a well-known non-steroidal anti-inflammatory active pharmaceutical ingredient (API), but it is poorly soluble in water, which makes its bioavailability relatively low. The aim of the work was to investigate the effect of polyvinylpyrrolidone (PVP) of different molecular weights on the phase solubility of nimesulide and to evaluate the thermodynamic parameters of the obtained complexes in order to determine the optimal polymer for further development of a solid dispersed system (SDS) of nimesulide and to study its physicochemical properties, which lead to an improvement in the sol

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12

Бессарабов, В. І., В. П. Плаван, Г. І. Кузьміна, В. М. Лісовий та Л. М. Вахіова. "Використання полімерних композиційних матеріалів для підвищення біодоступності гесперидина". Bulletin of the Kyiv National University of Technologies and Design. Technical Science Series 150, № 5 (2021): 74–82. http://dx.doi.org/10.30857/1813-6796.2020.5.7.

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Purpose. Investigation of the influence of the composition of polymeric solubilizers on the phase solubilization in water of the model active pharmaceutical ingredient of flavonoid nature hesperidin.Methods. Hesperidin was chosen as a model substance of characteristic chemical structure. Pharmaceutically acceptable high molecular weight polymers based on polyvinylpyrrolidone (PVP) with a molecular weight of from 2500 to 58000 D were used for research; cetylpyridinium chloride; β-cyclodextrin. Phase solubilization of hesperidin was investigated by the method of Higuchi and Connors. The concentr

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13

Sahu, Anjali, Khushi Chouksey та Kuldeep Ganju. "FORMULATING β-CYCLODEXTRIN INCLUSION COMPLEXES FOR SOLUTION STABILITY ENHANCEMENT OF GRISEOFULVIN". Journal of Advanced Scientific Research 13, № 08 (2022): 64–70. http://dx.doi.org/10.55218/jasr.202213810.

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Griseofulvin is a poorly soluble antifungal antibiotic drug, the solubility of which can be enhanced by complexation with β-cyclodextrin. The inclusion complex was prepared by Physical and Kneading method in various molar ratios of 1:1, 1:2 and 2:1 of the drug and β-cyclodextrin, respectively. IR spectra of drug, polymer and a physical mixture of drug and polymer were obtained using FT-IR. The inclusion complex was characterized and evaluated by determination of aqueous solubility, determination of pH stability, estimation of griseofulvin in complexes and stability study. The aqueous solubilit

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14

Chopade, Tanaji Abhiman Joshi Hrushikesh Anantrao. "PHASE SOLUBILITY STUDIES OF GLIMEPIRIDE WITH β-CYCLODEXTRIN AND HYDROXY PROPYL-β-CYCLODEXTRIN IN DIFFERENT pH". 31 серпня 2017. https://doi.org/10.5281/zenodo.2526817.

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An oral route of drug administration is most preferred rout of delivery, as it is convenient and ease of ingestion. One of the disadvantages of this rout is low bioavailability, as most of the drugs have poor solubility in water. In the case of poorly water-soluble drugs (BCS Class II and IV), dissolution is the rate-limiting step in the process of drug absorption. Cyclodextrins are widely used for to improve the physicochemical and pharmaceutical properties such as solubility, stability, and bioavailability of poorly soluble drug molecules. Glimepiride, is an antidiabetic drug, has poor solub

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15

Hernández-García, Lucero, Alberto Rojas-Hernández та Annia Galano. "Mangiferin/β-cyclodextrin complex: determination of the Inclusion constant in aqueous solution by Higuchi–Connors method and molecular absorption and photoluminescence UV spectroscopies at pH 3.4". Chemical Papers, 8 серпня 2022. http://dx.doi.org/10.1007/s11696-022-02381-z.

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16

KAUSHIK, SAKSHI, RAVINDER VERMA, DEEPIKA PUROHIT, et al. "DEVELOPMENT OF BINARY AND TERNARY COMPLEX OF CEFUROXIME AXETIL WITH CYCLODEXTRIN FOR IMPROVING PHARMACEUTICAL CHARACTERISTICS." International Journal of Applied Pharmaceutics, September 16, 2020, 107–17. http://dx.doi.org/10.22159/ijap.2020v12i6.38927.

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Objective: The current research objective is systematic development and characterization of binary and ternary inclusion complexes of cefuroxime axetil with β-cyclodextrin to improve its pharmaceutical characteristics by using the kneading method. Methods: Phase solubility study was carried out using Higuchi and Connors method. Based on its result, binary complexes of cefuroxime axetil with different ratio of β-cyclodextrin were developed and characterized using differential scanning calorimeter (DSC), fourier transform infrared spectroscopy (FT-IR) and X-ray powder diffractometry (XRD).

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17

Thi Thanh Binh, Nguyen, Ho Thi Quynh Xuan та Nguyen Thi Hai Yen. "Preparation and Characterization of Flurbiprofen/β-Cyclodextrin Inclusion Complex". VNU Journal of Science: Medical and Pharmaceutical Sciences 36, № 3 (2020). http://dx.doi.org/10.25073/2588-1132/vnumps.4259.

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This study aims to ameliorate the water solubility of flurbiprofen by using β-cyclodextrin (β-CD). The drug/ligand 1:1 (M/M) stoichiometry was determined based on the effect of β-CD on the solubility of flurbiprofen. Several methods of preparing flurbiprofen/β-CD inclusion complex were investigated and a solvent method using hot water to dissolve the starting materials was selected. The selected method showed a lot of advantages such as high complexing ability, good product yield, simple and eco-friendly process. The obtained product was characterized using various analytical techniques such a

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