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Journal articles on the topic 'HILIC-A'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Molnarova, Katarina, and Petr Kozlík. "Comparison of Different HILIC Stationary Phases in the Separation of Hemopexin and Immunoglobulin G Glycopeptides and Their Isomers." Molecules 25, no. 20 (2020): 4655. http://dx.doi.org/10.3390/molecules25204655.

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Protein glycosylation analysis is challenging due to the structural variety of complex conjugates. However, chromatographically separating glycans attached to tryptic peptides enables their site-specific characterization. For this purpose, we have shown the importance of selecting a suitable hydrophilic interaction liquid chromatography (HILIC) stationary phase in the separation of glycopeptides and their isomers. Three different HILIC stationary phases, i.e., HALO® penta-HILIC, Glycan ethylene bridged hybrid (BEH) Amide, and ZIC-HILIC, were compared in the separation of complex N-glycopeptide

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2

Alsaeedi, Majidah, Huda Alghamdi, Phyllis Hayes, Anna Hogan, and Jeremy Glennon. "Efficient Sub-1 Minute Analysis of Selected Biomarker Catecholamines by Core-Shell Hydrophilic Interaction Liquid Chromatography (HILIC) with Nanomolar Detection at a Boron-Doped Diamond (BDD) Electrode." Separations 8, no. 8 (2021): 124. http://dx.doi.org/10.3390/separations8080124.

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A rapid, sensitive method for the separation of catecholamine biomarkers (CAs), of importance in traumatic brain injury (TBI) and in Parkinson’s disease (PD), has been successfully developed using hydrophilic interaction liquid chromatography (HILIC). Dopamine (DA), epinephrine (EPI), and norepinephrine (NE) are known to be three to fivefold elevated above normal in traumatic brain injury (TBI) patients. HILIC facilitates the rapid and efficient separation of these polar biomarkers, which can be poorly retained by reversed-phase liquid chromatography (RPLC), while electrochemical detection (EC

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3

Peris-García, Ester, María José Ruiz-Angel, Juan José Baeza-Baeza, and María Celia García-Alvarez-Coque. "Comparison of the Fitting Performance of Retention Models and Elution Strength Behaviour in Hydrophilic-Interaction and Reversed-Phase Liquid Chromatography." Separations 8, no. 4 (2021): 54. http://dx.doi.org/10.3390/separations8040054.

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Hydrophilic interaction liquid chromatography (HILIC) is able to separate from polar to highly polar solutes, using similar eluents to those in the reversed-phase mode (RPLC) and a polar stationary phase, where water is adsorbed onto its surface. It is widely accepted that multiple modes of interaction take place in the HILIC environment, which can be far more complex than the interactions in an RPLC column. The behaviour in HILIC should be adequately modelled to predict the retention with optimisation purposes and improve the understanding on retention mechanisms, as is the case for RPLC. In

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4

Acevska, Jelena, Gjoshe Stefkov, Natalija Nakov, et al. "Chemometric approach for development, optimization and validation of HILIC methods used for the determination of alkaloids from poppy straw." Macedonian Journal of Chemistry and Chemical Engineering 33, no. 1 (2014): 73. http://dx.doi.org/10.20450/mjcce.2014.6.

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<p class="abstract">Two hydrophilic interaction liquid chromatography (HILIC) methods for simultaneous determination of the major alkaloids (morphine, codeine, thebaine, oripavine, papaverine and noscapine) in opium poppy straw (<em>Papaver somniferum</em> L., Papaveraceae) were developed.</p><p class="abstract">The chromatographic behavior of target alkaloids was investigated on two different HILIC stationary phases: bare silica (Si-HILIC) and zwitterionic (ZIC-HILIC). Systematic optimization of the methods was carried out by use of chemometrics. A full factorial

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Sommella, Eduardo, Emanuela Salviati, Simona Musella, Veronica Di Sarno, Francesco Gasparrini, and Pietro Campiglia. "Comparison of Online Comprehensive HILIC × RP and RP × RP with Trapping Modulation Coupled to Mass Spectrometry for Microalgae Peptidomics." Separations 7, no. 2 (2020): 25. http://dx.doi.org/10.3390/separations7020025.

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In this work, two online comprehensive two-dimensional liquid chromatography platforms, namely Hydrophilic interaction liquid chromatography × Reversed phase (HILIC × RP) and Reversed phase × Reversed Phase (RP × RP) coupled to mass spectrometry, were compared for the analysis of complex peptide samples. In the first dimension, a HILIC Amide and C18 Bioshell peptide (150 × 2.1 mm, 1.7 and 2.0 μm) columns were selected, while, in the second dimension, a short C18 (50 × 3.0 mm, 2.7 μm) Bioshell peptide column was used. Two C18 trapping columns (10 × 3.0 mm, 1.9 μm), characterized by high retenti

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6

Turrell, Elizabeth, Lesley Stobo, Jean-Pierre Lacaze, Sergey Piletsky, and Elena Piletska. "Optimization of Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry and Development of Solid-Phase Extraction for the Determination of Paralytic Shellfish Poisoning Toxins." Journal of AOAC INTERNATIONAL 91, no. 6 (2008): 1372–86. http://dx.doi.org/10.1093/jaoac/91.6.1372.

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Abstract The combination of hydrophilic interaction liquid chromatography (HILIC) and liquid chromatography/mass spectrometry (LC/MS) for the determination of paralytic shellfish poisoning (PSP) toxins has been proposed for use in routine monitoring of shellfish. In this study, methods for the detection of multiple PSP toxins [saxitoxin (STX), neosaxitoxin (NEO), decarbamoyl saxitoxin (dcSTX), decarbamoyl neosaxitoxin (dcNEO), gonyautoxins 15 (GTX1, GTX2, GTX3, GTX4, GTX5), decarbamoyl gonyautoxins (dcGTX2 and dcGTX3), and the N-sulfocarbamoyl C toxins (C1 and C2)] were optimized using single

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7

Ares, Ana, and José Bernal. "Hydrophilic interaction chromatography in drug analysis." Open Chemistry 10, no. 3 (2012): 534–53. http://dx.doi.org/10.2478/s11532-012-0003-8.

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AbstractHydrophilic interaction chromatography (HILIC) is an increasingly popular alternative to conventional HPLC for drug analysis. It offers increased selectivity and sensitivity, and improved efficiency when quantifying drugs and related compounds in complex matrices such as biological and environmental samples, pharmaceutical formulations, food, and animal feed. In this review we summarize HILIC methods recently developed for drug analysis (2006–2011). In addition, a list of important applications is provided, including experimental conditions and a brief summary of results. The reference

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8

Buszewski, Bogusław, and Sylwia Noga. "Hydrophilic interaction liquid chromatography (HILIC)—a powerful separation technique." Analytical and Bioanalytical Chemistry 402, no. 1 (2011): 231–47. http://dx.doi.org/10.1007/s00216-011-5308-5.

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9

Towner, Justin, Brian Rago, David Rodrigues, Manoli Vourvahis, and Chris Holliman. "A novel hydrophilic interaction chromatography assay characterization of 4-pyridoxic acid, an emergent renal organic anion transporter 1/3 transporter biomarker." Bioanalysis 13, no. 18 (2021): 1391–400. http://dx.doi.org/10.4155/bio-2021-0110.

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Aim: 4-pyridoxic acid (PDA) has been proposed as an endogenous biomarker for renal organic anion transporter 1/3 (OAT1/3) inhibition. Clinical data are needed to support the proposal. Materials & methods: A hydrophilic interaction chromatography (HILIC)–LC/MS/MS assay was developed and characterized to support clinical drug–drug interaction (DDI) studies. Results: A HILIC–LC/MS/MS assay was successfully developed. PDA was measured in two clinical DDI studies; one where no significant OAT1/3 inhibition was observed and a second where a known inhibitor of the transporter was dosed. In both c

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Fical, Luboš, Maria Khalikova, Hana Kočová Vlčková, et al. "Determination of Antiviral Drugs and Their Metabolites Using Micro-Solid Phase Extraction and UHPLC-MS/MS in Reversed-Phase and Hydrophilic Interaction Chromatography Modes." Molecules 26, no. 8 (2021): 2123. http://dx.doi.org/10.3390/molecules26082123.

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Two new ultra-high performance liquid chromatography (UHPLC) methods for analyzing 21 selected antivirals and their metabolites were optimized, including sample preparation step, LC separation conditions, and tandem mass spectrometry detection. Micro-solid phase extraction in pipette tips was used to extract antivirals from the biological material of Hanks balanced salt medium of pH 7.4 and 6.5. These media were used in experiments to evaluate the membrane transport of antiviral drugs. Challenging diversity of physicochemical properties was overcome using combined sorbent composed of C18 and i

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11

Galeano Garcia, Zimmermann, and Carazzone. "Hydrophilic Interaction Liquid Chromatography Coupled to Mass Spectrometry and Multivariate Analysis of the De Novo Pyrimidine Pathway Metabolites." Biomolecules 9, no. 8 (2019): 328. http://dx.doi.org/10.3390/biom9080328.

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In this study, we describe the optimization of a Hydrophilic Interaction Liquid Chromatography coupled to mass spectrometry (HILIC-MS) method for the evaluation of 14 metabolites related to the de novo synthesis of pyrimidines (dnSP) while using multivariate analysis, which is the metabolic pathway for pyrimidine nucleotide production. A multivariate design was used to set the conditions of the column temperature, flow of the mobile phase, additive concentration, gradient rate, and pH of the mobile phase in order to attain higher peak resolution and ionization efficiency in shorter analysis ti

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12

Jandera, Pavel, and Tomáš Hájek. "A New Definition of the Stationary Phase Volume in Mixed-Mode Chromatographic Columns in Hydrophilic Liquid Chromatography." Molecules 26, no. 16 (2021): 4819. http://dx.doi.org/10.3390/molecules26164819.

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Polar columns used in the HILIC (Hydrophilic Interaction Liquid Chromatography) systems take up water from the mixed aqueous–organic mobile phases in excess of the water concentration in the bulk mobile phase. The adsorbed water forms a diffuse layer, which becomes a part of the HILIC stationary phase and plays dominant role in the retention of polar compounds. It is difficult to fix the exact boundary between the diffuse stationary and the bulk mobile phase, hence determining the column hold-up volume is subject to errors. Adopting a convention that presumes that the volume of the adsorbed wa

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13

Peris-García, Ester, Raquel Burgos-Gil, María Celia García-Alvarez-Coque, and María José Ruiz-Angel. "Hydrophilic Liquid Chromatography versus Reversed-Phase Liquid Chromatography in the Absence and the Presence of 1-Hexyl-3-methylimidazolium Chloride for the Analysis of Basic Compounds." Separations 7, no. 2 (2020): 30. http://dx.doi.org/10.3390/separations7020030.

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In reversed-phase liquid chromatography (RPLC), positively charged basic compounds yield broad and asymmetric peaks, as a result of ionic interactions with free silanols that remain on conventional silica-based columns. Diverse solutions have been proposed to mask the silanophilic activity, which is translated to an improved peak shape. In this work, the chromatographic performance of hydrophilic interaction liquid chromatography (HILIC) was evaluated as an alternative to the addition of an ionic liquid (IL) to the aqueous-organic mobile phase used with RPLC columns, for the analysis of eight

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14

Si, Tiantian, Licheng Wang, Xiaofeng Lu, Xiaojing Liang, Shuai Wang, and Yong Guo. "An alternative approach for the preparation of a core–shell bimetallic central metal–organic framework as a hydrophilic interaction liquid chromatography stationary phase." Analyst 145, no. 11 (2020): 3851–56. http://dx.doi.org/10.1039/d0an00304b.

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15

Yan, Kui, Haiyan Yang, Shaohua Huang, and Zhengwu Bai. "A sulfonated chitooligosaccharide modified silica material for hydrophilic interaction liquid chromatography and its chromatographic evaluation." Analytical Methods 10, no. 10 (2018): 1258–65. http://dx.doi.org/10.1039/c8ay00070k.

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16

Narduzzi, Luca, Anne-Lise Royer, Emmanuelle Bichon, et al. "Ammonium Fluoride as Suitable Additive for HILIC-Based LC-HRMS Metabolomics." Metabolites 9, no. 12 (2019): 292. http://dx.doi.org/10.3390/metabo9120292.

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Hydrophilic Interaction Liquid Chromatography (HILIC) chromatography is widely applied in metabolomics as a complementary strategy to reverse phase chromatography. Nevertheless, it still faces several issues in terms of peak shape and compounds ionization, limiting the automatic de-convolution and data semi-quantification performed through dedicated software. A way to improve the chromatographic and ionization performance of a HILIC method is to modify the electrostatic interactions of the analytes with both mobile and stationary phases. In this study, using a ZIC-HILIC chromatographic phase,

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17

Pandey, Saurabh, Jayesh Dhanani, Jeffrey Lipman, Jason A. Roberts, Steve C. Wallis, and Suzanne L. Parker. "Development and validation of LC-MS/MS methods to measure tobramycin and lincomycin in plasma, microdialysis fluid and urine: application to a pilot pharmacokinetic research study." Clinical Chemistry and Laboratory Medicine (CCLM) 58, no. 2 (2020): 274–84. http://dx.doi.org/10.1515/cclm-2019-0780.

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AbstractBackgroundThe aim of our work was to develop and validate a hydrophilic interaction liquid chromatography-electrospray ionization-tandem mass spectrometry (HILIC-ESI-MS/MS) methods for the quantification of tobramycin (TMC) and lincomycin (LMC)in plasma, microdialysis fluid and urine.MethodsProtein precipitation was used to extract TMC and LMC from plasma, while microdialysis fluid and urine sample were diluted prior to instrumental analysis. Mobile phase A consisted of 2 mM ammonium acetate in 10% acetonitrile with 0.2% formic acid (v/v) and mobile phase B consisted of 2 mM ammonium a

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18

Mao, Zhenkun, Changjun Hu, Zhentao Li, and Zilin Chen. "A reversed-phase/hydrophilic bifunctional interaction mixed-mode monolithic column with biphenyl and quaternary ammonium stationary phases for capillary electrochromatography." Analyst 144, no. 14 (2019): 4386–94. http://dx.doi.org/10.1039/c9an00428a.

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19

van der Laan, Tom, Isabelle Boom, Joshua Maliepaard, Anne-Charlotte Dubbelman, Amy C. Harms, and Thomas Hankemeier. "Data-Independent Acquisition for the Quantification and Identification of Metabolites in Plasma." Metabolites 10, no. 12 (2020): 514. http://dx.doi.org/10.3390/metabo10120514.

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A popular fragmentation technique for non-targeted analysis is called data-independent acquisition (DIA), because it provides fragmentation data for all analytes in a specific mass range. In this work, we demonstrated the strengths and weaknesses of DIA. Two types of chromatography (fractionation/3 min and hydrophilic interaction liquid chromatography (HILIC)/18 min) and three DIA protocols (variable sequential window acquisition of all theoretical mass spectra (SWATH), fixed SWATH and MSALL) were used to evaluate the performance of DIA. Our results show that fast chromatography and MSALL ofte

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20

Gosetti, Fabio, Eleonora Mazzucco, Andrea Secco, Elisa Robotti, Marcello Manfredi, and Emilio Marengo. "A hydrophilic interaction liquid chromatography–tandem mass spectrometry method for the identification and determination of cationic starch derivatives in air samples." Analytical Methods 9, no. 10 (2017): 1634–42. http://dx.doi.org/10.1039/c6ay03409h.

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21

Ji, Shunli, Yang Zheng, Feifang Zhang, Xinmiao Liang, and Bingcheng Yang. "A polyvinyl alcohol-coated silica gel stationary phase for hydrophilic interaction chromatography." Analyst 140, no. 18 (2015): 6250–53. http://dx.doi.org/10.1039/c5an01159k.

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22

Wang, Meng, Ryoichi Hiraki, Norihiro Nakamura, et al. "Determination of Gemcitabine in Plasma of Bladder Cancer Patients by Hydrophilic Interaction Chromatography with Ultraviolet Detection." Journal of Chromatographic Science 58, no. 7 (2020): 587–90. http://dx.doi.org/10.1093/chromsci/bmaa020.

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Abstract Gemcitabine is a deoxycytidine analog that has been used for a broad spectrum of tumor, such as nonsmall-cell lung cancer, bladder cancer and pancreatic cancer. Because gemcitabine is hydrophilic, hydrophilic interaction liquid chromatography (HILIC), where analytes are retained on a polar column according to their hydrophilicity, should be adequate for separation analysis of gemcitabine. In the present study, we proposed a hydrophilic interaction chromatography with ultraviolet (HILIC-UV) method with liquid–liquid extraction and adding tetrahydrouridine to plasma samples for gemcitab

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Yan, Xun. "Short-Chain Polysaccharide Analysis in Ethanol–Water Solutions." Journal of AOAC INTERNATIONAL 100, no. 4 (2017): 1134–36. http://dx.doi.org/10.5740/jaoacint.16-0426.

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Abstract This study demonstrates that short-chain polysaccharides, or oligosaccharides, could be sufficiently separated with hydrophilic interaction LC (HILIC) conditions and quantified by evaporative light-scattering detection (ELSD). The multianalyte calibration approach improved the efficiency of calibrating the nonlinear detector response. The method allowed easy quantification of short-chain carbohydrates. Using the HILIC method, the oligosaccharide solubility and its profile in water/alcohol solutions at room temperature were able to be quantified. The results showed that the polysacchar

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Sun, Yongming, Biqi Xia, Xiangzhun Chen, Chuansong Duanmu, Denghao Li, and Chao Han. "Rapid Quantification of Four Anthocyanins in Red Grape Wine by Hydrophilic Interaction Liquid Chromatography/ Triple Quadrupole Linear Ion Trap Mass Spectrometry." Journal of AOAC INTERNATIONAL 98, no. 6 (2015): 1628–31. http://dx.doi.org/10.5740/jaoacint.15-098.

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Abstract The identification and quantification of four anthocyanins (cyanidin-3-O -glucoside, peonidin- 3-O -glucoside, delphinidin-3-O -glucoside, and malvidin-3-O-glucoside) in red grape wine were carried out by hydrophilic interaction liquid chromatography/triple quadrupole linear ion trap MS (HILIC/QTrap-MS/MS). Samples were diluted directly and separated on a Merck ZIC HILIC column with 20 mM ammonium acetate solution–acetonitrile mobile phase. Quantitative data acquisition was carried out in the multiple reaction monitoring mode. Additional identification and confirmation of target compo

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Gargano, Andrea F. G., Liana S. Roca, Ryan T. Fellers, Max Bocxe, Elena Domínguez-Vega, and Govert W. Somsen. "Capillary HILIC-MS: A New Tool for Sensitive Top-Down Proteomics." Analytical Chemistry 90, no. 11 (2018): 6601–9. http://dx.doi.org/10.1021/acs.analchem.8b00382.

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Berthelette, Kenneth D., Thomas H. Walter, Martin Gilar, Fabrice Gritti, Thomas S. MacDonald, and Miguel Soares. "Evaluating MISER chromatography as a tool for characterizing HILIC column equilibration." Journal of Chromatography A 1619 (May 2020): 460931. http://dx.doi.org/10.1016/j.chroma.2020.460931.

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27

Lu, Haoyang, Xiaoyun Zeng, Lihua Yu, et al. "Development and Validation of a Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry Method for the Determination of Asparagine in Human Serum." International Journal of Analytical Chemistry 2020 (February 28, 2020): 1–9. http://dx.doi.org/10.1155/2020/6980392.

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L-Asparagine (ASN) is the catalyze substrate of L-asparaginase (ASNase), which is an important drug for acute lymphoblastic leukemia (ALL) patients. The ASN level is found to be closely associated with the effectiveness of ASNase treatment. In this study, a hydrophilic interaction liquid chromatography tandem mass spectrometry (HILIC-MS/MS) method was developed for the determination of ASN in the human serum using a stable isotope-labeled internal standard (ASN-D3). Serum samples were prepared by a one-step precipitation procedure using methanol and separated by an Agilent HILIC Plus column wi

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Wouters, Sam, Sebastiaan Eeltink, Rob Haselberg, Govert W. Somsen, and Andrea F. G. Gargano. "Microfluidic ion stripper for removal of trifluoroacetic acid from mobile phases used in HILIC-MS of intact proteins." Analytical and Bioanalytical Chemistry 413, no. 17 (2021): 4379–86. http://dx.doi.org/10.1007/s00216-021-03414-4.

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AbstractTrifluoroacetic acid (TFA) is commonly used as mobile phase additive to improve retention and peak shape characteristics in hydrophilic interaction liquid chromatography (HILIC) of intact proteins. However, when using electrospray ionization-mass spectrometry (ESI-MS) detection, TFA may cause ionization suppression and adduct formation, leading to reduced analyte sensitivity. To address this, we describe a membrane-based microfluidic chip with multiple parallel channels for the selective post-column removal of TFA anions from HILIC. An anion-exchange membrane was used to physically sep

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Song, Qingqing, Yunfang Zhao, Xiaojia Chen, et al. "New instrumentation for large-scale quantitative analysis of components spanning a wide polarity range by column-switching hydrophilic interaction chromatography-turbulent flow chromatography-reversed phase liquid chromatography-tandem mass spectrometry." RSC Advances 7, no. 51 (2017): 31838–49. http://dx.doi.org/10.1039/c7ra03788k.

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Miękus, Natalia, Lucyna Konieczna, Przemysław Kowiański, Janusz Moryś, and Tomasz Bączek. "HILIC-MS rat brain analysis, a new approach for the study of ischemic attack." Translational Neuroscience 8, no. 1 (2017): 70–75. http://dx.doi.org/10.1515/tnsci-2017-0012.

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AbstractClinicians often rely on selected small molecular compounds from body fluids for the detection, screening or monitoring of numerous life-threatening diseases. Among others, important monoamines – biogenic amines (BAs) – and their metabolites serve as sensitive biomarkers to study the progression or even early detection of on-going brain pathologies or tumors of neuroendocrine origins. Undertaking the task to optimize a reliable method for the simultaneous analysis of the most relevant BAs in biological matrices is of utmost importance for scientists.Hydrophilic interaction liquid chrom

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Li, Lei, Yunpeng Liu, Cheng Ma, et al. "Efficient chemoenzymatic synthesis of an N-glycan isomer library." Chemical Science 6, no. 10 (2015): 5652–61. http://dx.doi.org/10.1039/c5sc02025e.

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Raikou, Vasiliki, Eleni Kalogria, Athanasia Varvaresou, Efthimios Tsirivas, and Irene Panderi. "Quantitation of Acetyl Hexapeptide-8 in Cosmetics by Hydrophilic Interaction Liquid Chromatography Coupled to Photo Diode Array Detection." Separations 8, no. 8 (2021): 125. http://dx.doi.org/10.3390/separations8080125.

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Bioactive peptides are gaining more and more popularity in the research and development of cosmetic products with anti-aging effect. Acetyl hexapeptide-8 is a hydrophilic peptide incorporated in cosmetics to reduce the under-eye wrinkles and the forehead furrows. Hydrophilic interaction liquid chromatography (HILIC) is the separation technique of choice for analyzing peptides. In this work, a rapid HILIC method coupled to photodiode array detection operated at 214 nm was developed, validated and used to determine acetyl-hexapeptide-8 in cosmetics. Chromatography was performed on a Xbridge® HIL

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Wang, Qian, Yue Yuan, Mingxin Li, et al. "Application of solvent demulsification dispersive liquid–liquid microextraction for nicotine and cotinine measurement in human urine combined with hydrophilic interaction chromatography tandem mass spectrometry." Analytical Methods 9, no. 29 (2017): 4311–18. http://dx.doi.org/10.1039/c7ay00840f.

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Staples, Gregory O., Michael J. Bowman, Catherine E. Costello, et al. "A chip-based amide-HILIC LC/MS platform for glycosaminoglycan glycomics profiling." PROTEOMICS 9, no. 3 (2009): 686–95. http://dx.doi.org/10.1002/pmic.200701008.

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Liu, Xiaodong, and Christopher A. Pohl. "HILIC behavior of a reversed-phase/cation-exchange/anion-exchange trimode column." Journal of Separation Science 33, no. 6-7 (2010): 779–86. http://dx.doi.org/10.1002/jssc.200900645.

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Bertuzzi, Terenzio, Barbara Agosti, Alessia Gualla, and Amedeo Pietri. "LC–MS–MS Determination of Sanguinarine and Chelerythrine Using a HILIC Column." Chromatographia 72, no. 9-10 (2010): 969–73. http://dx.doi.org/10.1365/s10337-010-1745-0.

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Redón, Lídia, Xavier Subirats, and Martí Rosés. "HILIC characterization: Estimation of phase volumes and composition for a zwitterionic column." Analytica Chimica Acta 1130 (September 2020): 39–48. http://dx.doi.org/10.1016/j.aca.2020.06.035.

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Jang, Seok-In, Han Young Eom, Jeong Ho Hwang, Lila Kim, and Jong-Hwa Lee. "Simultaneous Quantification of 3′- and 6′-Sialyllactose in Rat Plasma Using Liquid Chromatography-Tandem Mass Spectrometry and Its Application to a Pharmacokinetic Study." Molecules 26, no. 4 (2021): 1177. http://dx.doi.org/10.3390/molecules26041177.

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Sialyllactose (SL), an acidic oligosaccharide, has immune-protective effects against pathogens and helps with the development of the immune system and intestinal microorganisms. To elucidate the pharmacokinetic characterization after oral administration to rats, the simultaneous quantification method for 3′-SL and 6′-SL in rat plasma was validated, using liquid chromatography-tandem mass spectrometry (LC-MS/MS) in an electrospray ionization (ESI) mode. Several types of columns [C18, amide, and hydrophilic interaction liquid chromatography (HILIC) phase] were used to separate the peaks of 3′-SL

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Peng, Yahui, Feifang Zhang, Xiao Pan, Yanjie Hou, and Bingcheng Yang. "Poly(vinyl alcohol)–cationic cellulose copolymer encapsulated SiO2 stationary phase for hydrophilic interaction liquid chromatography." RSC Advances 7, no. 34 (2017): 21336–41. http://dx.doi.org/10.1039/c7ra01958k.

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Panderi, Irene, Eugenia Taxiarchi, Constantinos Pistos, Eleni Kalogria, and Ariadni Vonaparti. "Insights into the Mechanism of Separation of Bisphosphonates by Zwitterionic Hydrophilic Interaction Liquid Chromatography: Application to the Quantitation of Risedronate in Pharmaceuticals." Separations 6, no. 1 (2019): 6. http://dx.doi.org/10.3390/separations6010006.

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Bisphosphonates are used to treat various skeletal disorders, as they modulate bone metabolism by inhibition of the osteoclast-mediated bone resorption. These compounds are both polar and ionic, and therefore, by using reversed phase liquid chromatography are eluted rapidly. Hydrophilic interaction liquid chromatography (HILIC) is an advantageous technique for the separation and analysis of polar molecules. As the elution order in HILIC is reversed to reversed phase liquid chromatography, a reasonable retention and selectivity for polar compounds is expected. In this work the retention mechani

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Andrade-Eiroa, Auréa, Roya Shahla, Manolis N. Romanías, and Philippe Dagaut. "An alternative to trial and error methodology in solid phase extraction: an original automated solid phase extraction procedure for analysing PAHs and PAH-derivatives in soot." RSC Adv. 4, no. 63 (2014): 33636–44. http://dx.doi.org/10.1039/c4ra03214d.

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This paper introduces the generalization of reverse-phase HPLC fundamentals to normal-phase liquid chromatography, hydrophilic interaction chromatography (HILIC) and Automated Solid Phase Extraction (A-SPE).

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Guo, Yong. "Recent progress in the fundamental understanding of hydrophilic interaction chromatography (HILIC)." Analyst 140, no. 19 (2015): 6452–66. http://dx.doi.org/10.1039/c5an00670h.

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Pérez-Míguez, Raquel, María Castro-Puyana, Elena Sánchez-López, Merichel Plaza, and María Luisa Marina. "Untargeted HILIC-MS-Based Metabolomics Approach to Evaluate Coffee Roasting Process: Contributing to an Integrated Metabolomics Multiplatform." Molecules 25, no. 4 (2020): 887. http://dx.doi.org/10.3390/molecules25040887.

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Abstract:

An untargeted metabolomics strategy using hydrophilic interaction chromatography-mass spectrometry (HILIC-MS) was developed in this work enabling the study of the coffee roasting process. Green coffee beans and coffee beans submitted to three different roasting degrees (light, medium, and strong) were analyzed. Chromatographic separation was carried out using water containing 10 mM ammonium formate with 0.2 % formic acid (mobile phase A) and acetonitrile containing 10 mM ammonium formate with 0.2 % formic acid (mobile phase B). A total of 93 molecular features were considered from which 31 wer

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Oehrle, Stuart, Kathryn SP Higginbotham, and Erin D. Strome. "A Benchtop Approach To Measuring S-AdenosylMethionine Metabolite Levels Using HILIC UPLC-MS." Journal of the Kentucky Academy of Science 80, no. 1 (2019): 1. http://dx.doi.org/10.3101/1098-7096-80.1.1.

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Wei, Jianqiang, Hui Wang та Song Wu. "A HILIC Mechanism Discussion for the Retention of HP-β-CD". OALib 01, № 04 (2014): 1–6. http://dx.doi.org/10.4236/oalib.1100435.

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Liu, Qi, Weiya Zhang, Hongyu Wang, et al. "Validation of a HILIC Method for the Analysis of Ergothioneine in Fermentation Broth." Journal of Chromatographic Science 54, no. 6 (2016): 934–38. http://dx.doi.org/10.1093/chromsci/bmw023.

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Stander, Marietjie A., Wernich Kühn, and Nicholas F. Hiten. "Survey of South African fruit juices using a fast screening HILIC-MS method." Food Additives & Contaminants: Part A 30, no. 9 (2013): 1473–84. http://dx.doi.org/10.1080/19440049.2013.811545.

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Yuan, Qin, Zhaojiang Liao, Fengling Wang, Huilian Zhang, Yali Guo, and Ruiping Li. "A RAPID HILIC METHOD FOR ANALYSIS OF DIAZEPAM AND ESTAZOLAM IN HUMAN PLASMA." Journal of Liquid Chromatography & Related Technologies 36, no. 7 (2013): 958–67. http://dx.doi.org/10.1080/10826076.2012.678459.

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Virgiliou, Christina, Ioannis Sampsonidis, Helen G. Gika, Nikolaos Raikos, and Georgios A. Theodoridis. "Development and validation of a HILIC-MS/MS multitargeted method for metabolomics applications." ELECTROPHORESIS 36, no. 18 (2015): 2215–25. http://dx.doi.org/10.1002/elps.201500208.

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Tyteca, Eva, Stefan Bieber, Thomas Letzel, and Gert Desmet. "Possibilities and Limitations of Computer-Assisted Method Development in HILIC: A Case Study." Chromatographia 80, no. 5 (2016): 771–81. http://dx.doi.org/10.1007/s10337-016-3127-8.

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