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Dissertations / Theses on the topic 'Hippocampus (Brain) Memory'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Manns, Joseph Robert. "Episodic memory, semantic memory, and the human hippocampus /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 2002. http://wwwlib.umi.com/cr/ucsd/fullcit?p3061654.

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Wais, Peter Edward. "The roles of the hippocampus in recognition memory." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3315575.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed September 3, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 128-137).

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3

Yim, Tonia Tan-Ling, and University of Lethbridge Faculty of Arts and Science. "Multiple-object memory requires the hippocampus." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2007, 2007. http://hdl.handle.net/10133/678.

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This thesis investigates the role of the hippocampus in object memory. Currently, the role of the hippocampus in object recognition is unclear, with some studies demonstrating a delay-dependent impairment after hippocampal damage, others showing no impairment. The present thesis used the novel object recognition task and its variants to investigate various types of object memory in hippocampal lesion rats. In the first study, impairments were observed in discriminating object order and associating objects with contexts, while no impairment was observed in novel object recognition. In the secon

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4

Gulbrandsen-MacDonald, Tine L., and University of Lethbridge Faculty of Arts and Science. "The role of the hippocampus and post-learning hippocampal activity in long-term consolidation of context memory." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2011, 2011. http://hdl.handle.net/10133/2635.

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Sutherland, Sparks and Lehmann (2010) proposed a new theory of memory consolidation, termed Distributed Reinstatement Theory (DRT), where the hippocampus (HPC) is needed for initial encoding but some types of memories are established in non-HPC systems through post-learning HPC activity. An evaluation of the current methodology of temporary inactivation was conducted experimentally. By permanently implanting two bilateral guide cannulae in the HPC and infusing ropivacaine cellular activity could be reduced by 97%. Rats were trained in a context-fear paradigm. Six learning episodes distributed

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5

McNeill, Damon Lee. "Hippocampal damage and novelty preference in the ischemic gerbil dissociating object and arrangement memory /." Thesis, Montana State University, 2007. http://etd.lib.montana.edu/etd/2007/mcneill/McNeillD0507.pdf.

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The most insidious consequences of transient ischemia are its effect on the hippocampus and the memory systems it serves. The novelty preference test is a direct measure of memory function and has been used in the rat and primate animal models. The gerbil animal model has been used extensively to study the mechanism of ischemic brain damage; however, the novelty preference paradigm has not been used to study memory impairment in this species. In addition, the novelty preference paradigm has not been tested with models of ischemia. In the present experiment, Mongolian gerbils were tested in two

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6

Krebs, Desiree L. "Glucose modulation of the septo-hippocampal system implications for memory /." unrestricted, 2006. http://etd.gsu.edu/theses/available/etd-09272006-142645/.

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Thesis (Ph. D.)--Georgia State University, 2006.<br>Marise B. Parent, committee chair; Timothy J. Bartness, Kim L. Huhman, Kyle J. Frantz, committee members. Electronic text (352 p. : ill.)) : digital, PDF file. Description based on contents viewed July 12, 2007. Includes bibliographical references (p. 307-352).

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7

Epp, Jonathon, and University of Lethbridge Faculty of Arts and Science. "The hippocampus, retrograde amnesia, and memory deconsolidation." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2005, 2005. http://hdl.handle.net/10133/219.

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There are numerous clinical and experimental accounts of retrograde and anterograde amnesia resulting from damage to the hippocampus (HPC). Several theories on the HPC hold that only certain types of recent memories should be affected by HPC damage. These theories do not accurately predict the circumstances within which memories are vulnerable to HPC damage. Here I show the HPC plays a role in the formation and storage of a wider range of memories than is posited in contemporary theories. I will demonstrate that an important factor in elciting retrograde amnesia is the number of similar learni

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8

Koene, Randal A. "Functional requirements determine relevant ingredients to model for on-line acquisition of context dependent memory." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85561.

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Biophysical simulations of memory must choose which aspects of known neurophysiology and neuroanatomy to model. Relevant aspects were constrained by functional requirements determined for on-line acquisition in context dependent memory, memory that is retrieved by contextual cues. In an on-line task, the protocol of data presentation and the tunes at which encoding or retrieval in memory is needed are not predetermined. A sequence of neuronal spike patterns representing items may be presented only once. Yet, episodic memory of the sequence immediately encodes the temporal context of fam

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9

Packard, Mark G. "The organization of memory in the brain : role of caudate nucleus and hippocampus." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74684.

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The present experiments were designed to examine the hypothesis that the hippocampus and caudate nucleus are parts of independent memory systems which differ in the type of memory they mediate. In experiment 1, the mnemonic functions of the hippocampus and caudate were doubly dissociated; lesions of the caudate nucleus impaired acquisition of the "habit memory" component of the 4 x 4 radial maze task, but had no effect the "cognitive memory" component of the task. Lesions of the fimbria-fornix produced the opposite behavioral dissociation. In experiment 2, lesions of the caudate nucleus produc

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10

Sparks, Fraser T. "Interactions of the hippocampus and non-hippocampal long-term memory systems during learning, remembering, and over time." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2012, 2012. http://hdl.handle.net/10133/3116.

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The hippocampus and non-hippocampal long-term memory systems each have the capacity to learn and express contextual fear memory. How these systems interact during learning and remembering revolves around hippocampal mediated interference, where the hippocampus dominates for both the acquisition and expression of long-term memory. Hippocampal interference during learning can be overcome by modifying learning parameters such that learning is distributed across multiple independent sessions. The standard view of the role of the hippocampus in long-term memory retrieval is that it is temporally li

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11

Murtha, Susan (Susan J. E. ). Carleton University Dissertation Psychology. "Neurotoxin induced lesions of acetylcholine and Serotonin afferents to the hippocampus; mnemonic, neurochemical, and histopathological effects." Ottawa, 1993.

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12

Coombs, Katie Marie. "Behavioral consequences following AAV mediated hippocampal EAAC1 knockdown." Thesis, Montana State University, 2007. http://etd.lib.montana.edu/etd/2007/coombs/CoombsK0507.pdf.

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13

O'Neill, Joseph. "Reactivation of waking firing patterns during sleep." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670153.

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14

McDonald, Robert James. "Interactions among learning and memory systems : amygdala, dorsal striatum, and hippocampus." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28491.

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This series of experiments used the multiple learning and memory systems hypothesis of the mammalian nervous system to investigate the possibility that the amygdala, dorsal striatum, and hippocampal systems might, in certain situations, interact to produce behavior in the normal animal. Using variations of the conditioned-cue preference (CCP) task, evidence is presented showing that context-specific information acquired by the hippocampus interferes with acquisition of amygdala-based stimulus-reward learning. It was also demonstrated that there are amygdala-, dorsal striatum-, and hippocampus-

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15

Driscoll, Ira, and University of Lethbridge Faculty of Arts and Science. "The aging hippocampus : a multilevel analysis in the rat." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2005, 2005. http://hdl.handle.net/10133/12.

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The purpose of the current thesis was twofold: (1) to examine various factors that might be contributing to age-related learning and memory deficits specifically related to the hippocampus, and (2) to validate our rat model of aging, employing a multilevel analysis. We found age-related deficits on both spatial and non-spatial hippocampus-dependent taks that were accompanied by structural alterations observed in vivo (volune, but not neuronal metabolic function) and post mortem (neuronal density and neurogenesis, but not synaptic or mitochondrial density). Furthermore, our results suggest th

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16

Espinoza, Guillermo Ysidro. "Granule cell plasticity in the developing rat hippocampus from specific reward schedule experience in learning /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004262.

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17

Quirk, Michael C. (Michael Clayton) 1974. "Neural mechanisms involved in memory formation and retrieval within the rodent hippocampus : an in vivo electrophysiological study." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/8353.

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Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2002.<br>Includes bibliographical references.<br>While it is well established that the rodent hippocampus plays a crucial role in the formation and retrieval of spatial memories, the neural mechanisms underlying this process have not been completely characterized. In this thesis I have combined large-scale recordings from multiple single cells within the hippocampus of behaving rodents with pharmacological and genetic manipulations of hippocampal function in order to investigate how the cellular and n

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18

Chai, Sin-Chee 1969. "The functions of amygdala and hippocampus in conditioned cue preference learning /." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38470.

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The experiments in this thesis examined the roles of stimulus configuration on conditioned cue preference (CCP) learning by asking what information is processed and by which neural substrates. Results from Experiments 1 and 2 showed that lesions of the lateral nucleus of the amygdala (LNA) but not of fimbria-fornix (FF) impaired CCP learning when the cues paired with food during training were distinct from those not paired with food in either of two different apparatuses. In Experiments 3 and 4 LNA lesions increased the size of the CCP when the cues paired with food and no food were ambiguous

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19

Hulme, Sarah R., and n/a. "Heterosynaptic metaplasticity in area CA1 of the hippocampus." University of Otago. Department of Psychology, 2009. http://adt.otago.ac.nz./public/adt-NZDU20090818.161738.

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Long-term potentiation (LTP) is an activity-dependent increase in the efficacy of synaptic transmission. In concert with long-term depression (LTD), this synaptic plasticity likely underlies some types of learning and memory. It has been suggested that for LTP/LTD to act as effective memory storage mechanisms, homeostatic regulation is required. This need for plasticity regulation is incorporated into the Bienenstock, Cooper and Munro (BCM) theory by a threshold determining LTD/LTP induction, which is altered by the previous history of activity (Bienenstock et al., 1982). The present work aime

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20

Cole, Rachel Amelia Clark. "Beneficial contribution of health behaviors to learning and related brain mechanisms in older adults." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6080.

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Aging is associated with adverse structural and functional changes in the brain. These changes have been directly linked to declines in certain types of learning and memory, likely due to the negative impact of aging on the hippocampus, a region necessary for cognitive functions such as relational learning, memory, and spatial navigation. Health behaviors and characteristics, like exercise and cardiorespiratory fitness (CRF), are related to better brain and cognitive aging, though more research is needed to better understand which age-sensitive aspects of cognitive function are most benefited

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21

Lee, Albert K. (Albert Kimin) 1972. "Combinatorial analysis of sequential firing patterns across multiple neurons decoding memory of sequential spatial experience in rat hippocampus." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/29932.

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Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2003.<br>Includes bibliographical references (p. 100-104).<br>There is broad agreement that the hippocampus is crucially involved in the formation of richly-detailed, long term memories of events in humans. A key aspect of such memories is the temporal order and spatial context of the events experienced. Evidence from a wide variety of behavioral and electrophysiological experiments indicates that the rodent hippocampal spatial memory system is a model system for studying this type of memory in humans

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22

Roberts, Michael J. 1973. "NMDA receptor activity is necessary for long-term memory in the non-spatial, hippocampal-dependent, social transmission of food preference task." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31532.

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Memory of some forms requires the hippocampus, a brain structure in the medial temporal lobe that reveals remarkable synaptic plasticity. Most synapses in the hippocampus require NMDA-receptors for the induction of this plasticity. Memories that require the hippocampus may also require NMDA-receptor mediated plasticity. This thesis tested the involvement of NMDA receptor activity in memory for a non-spatial, social learning task that requires the hippocampus: the social transmission of food preference, NMDA receptor antagonist (CPP) injected systemically 55 minutes prior to training impaired p

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23

Day, Elaine Baird. "Medial and dorsal cortex function and foraging strategy in lizards /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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24

Whiting, Mark D. "Cognitive Mechanisms of Memory Impairment Following Traumatic Brain Injury." VCU Scholars Compass, 2007. http://hdl.handle.net/10156/2040.

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25

Verma, Manu. "Deficiency of 11β-HSD1 modulates energy homeostasis in the brain following systemic inflammation". Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/33323.

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Chronically elevated brain glucocorticoid (GC) levels impair cognition. Age-related cognitive deficits or "sickness" behaviour is often associated with neuroinflammation. In rodents, raised GC levels prior to lipopolysaccharide (LPS) administration potentiate neuroinflammation although GC suppresses neuroinflammation if administered after LPS. 11β-hydroxysteroid dehydrogenase-1 (11β-HSD1) reductase activity can increase intracellular GC levels, including in the brain, without alteration in circulating levels. Deficiency/pharmacological inhibition of 11β-HSD1 is protective against age related c

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26

Lundberg, Louise. "Effect of exposure to electromagnetic fields on brain function and behaviour in mice." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:ec41f92c-f240-4821-8120-0d33a38d3eb7.

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There is a need for improved understanding of interactions between electromagnetic fields and biological tissues. In this thesis, the effects of exposure to 50 Hz magnetic fields, associated with power generation and use, and 1800 MHz fields associated with mobile phones were investigated with particular focus on the plastic processes that are involved in cognitive function. After repeated, daily exposure of young adult C57Bl/6J mice to an 1800 MHz field at 3 W/kg, very subtle changes in expression of genes involved in synaptic plasticity were found (p < 0.05). Spatial memory as measured in th

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Pudas, Sara. "Brain characteristics of memory decline and stability in aging : Contributions from longitudinal observations." Doctoral thesis, Stockholms universitet, Psykologiska institutionen, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-93026.

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Aging is typically associated with declining mental abilities, most prominent for some forms of memory. There are, however, large inter-individual differences within the older population. Some people experience rapid decline whereas others seem almost spared from any adverse effects of aging. This thesis examined the neural underpinnings of such individual differences by using longitudinal observations of episodic memory change across 15-20 years, combined with structural and functional magnetic resonance imaging of the brain. Study I found significant correlations between volume and activity

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Pan, Meixia, and 潘妹霞. "Effects of phytoestrogens on hippocampal neuron proliferation and spatial memory performance in ovariectomized rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B4370377X.

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Pan, Meixia. "Effects of phytoestrogens on hippocampal neuron proliferation and spatial memory performance in ovariectomized rats." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B4370377X.

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30

Packard, Mark G. "Differential roles of hippocampus and caudate nucleus in memory : selective mediation of "cognitive" and "associative" learning." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=64070.

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31

Lu, Xiaodong, and n/a. "Contribution of the perirhinal cortex to the firing properties of hippocampal pyramidal neurons." University of Otago. Department of Psychology, 2007. http://adt.otago.ac.nz./public/adt-NZDU20080128.154906.

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The hippocampus appears to carry out spatial memory processing and navigation. As one of the inputs to the hippocampus originates in the perirhinal cortex and the spatial behaviour is affected by lesion of the perirhinal cortex, this structure may be critical for the functioning of hippocampal place cells. To investigate this hypothesis, the firing properties of hippocampal place cells were compared between control rats and rats with perirhinal cortex lesions. Rats were randomly assigned to control and lesion groups. Animals from both groups received recording electrode implantation and the

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Puighermanal, Puigvert Emma 1983. "Molecular mechanisms underlying the effects of cannabinoids in the brain." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/53574.

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The endocannabinoid system is an endogenous neuromodulatory system that regulates a plethora of physiological functions, including the control of movement, memory, anxiety, and pain, among others. Cannabinoid compounds are mainly found in the Cannabis sativa plant and exert their effects by acting at the endocannabinoid system. Cannabinoids are potential therapeutic agents, mainly for multiple sclerosis, pain, and emesis, although an important caveat to their use is the possible adverse effects, such as memory impairment and anxiety. This thesis mainly addresses the molecular mechanisms underl

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33

Spanswick, Simon, and University of Lethbridge Faculty of Arts and Science. "A behavioural analysis of visual pattern separation ability by rats : effects of damage to the hippocampus." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2005, 2005. http://hdl.handle.net/10133/236.

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Different events usually contain similar elements that can contribute to interference during memory encoding and retrieval. The hippocampus (HPC), a structure that is critically involved in some forms of memory, has been hypothesized to reduce interference between memories with overlapping content, thus facilitating correct recall. Pattern separation is one hypothetical process whereby input ambiguity is reduced. Here we test the hypothesis that the HPC and/or dentate gyrus (DG) are important for pattern separation by measuring performance by rats with damage in tasks that require discriminati

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34

Bodily, Ty Alvin. "A Graph Theoretical Analysis of Functional Brain Networks Related to Memory and Healthy Aging." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7567.

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The cognitive decline associated with healthy aging begins in early adulthood and is important to understand as a precursor of and relative to mild cognitive impairment and Alzheimer disease. Anatomical atrophy, functional compensation, and network reorganization have been observed in populations of older adults. In the current study, we examine functional network correlates of memory performance on the Wechsler Memory Scale IV and the Mnemonic Discrimination Task (MST). We report a lack of association between global graph theory metrics and age or memory performance. In addition, we observed

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35

Flesher, Mary Melissa. "Acetylcholine levels in the prefrontal cortex and hippocampus during trace and delay conditioning." CSUSB ScholarWorks, 2008. https://scholarworks.lib.csusb.edu/etd-project/3370.

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36

Pyter, Leah M. "Seasonal plasticity of physiological systems, brain, and behavior." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1141319505.

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37

Fu, Yu. "Modulating effects of Chinese green tea on hippocampal neurons against glutamate neurotoxicity and hippocampal dependent memory during aging in mice." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B32017893.

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Fu, Yu, and 傅玉. "Modulating effects of Chinese green tea on hippocampal neurons againstglutamate neurotoxicity and hippocampal dependent memory during agingin mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B32017893.

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Puryear, Corey Brown. "A role for hippocampal and midbrain neural processing in context-dependent spatial memory /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/9165.

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Greer, Kisha Michelle. "Aberrant hippocampal neurogenesis contributes to learning and memory deficits in a mouse model of repetitive mild traumatic brain injury." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/94329.

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Adult hippocampal neurogenesis, or the process of creating new neurons in the dentate gyrus (DG) of the hippocampus, underlies learning and memory capacity. This cognitive ability is essential for humans to operate in their everyday lives, but cognitive disruption can occur in response to traumatic insult such as brain injury. Previous findings in rodent models have characterized the effect of moderate traumatic brain injury (TBI) on neurogenesis and found learning and memory shortfalls correlated with limited neurogenic capacity. While there are no substantial changes after one mild TBI, r

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Greer, Kisha. "Aberrant hippocampal neurogenesis contributes to learning and memory deficits in a mouse model of repetitive mild traumatic brain injury." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/94329.

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Adult hippocampal neurogenesis, or the process of creating new neurons in the dentate gyrus (DG) of the hippocampus, underlies learning and memory capacity. This cognitive ability is essential for humans to operate in their everyday lives, but cognitive disruption can occur in response to traumatic insult such as brain injury. Previous findings in rodent models have characterized the effect of moderate traumatic brain injury (TBI) on neurogenesis and found learning and memory shortfalls correlated with limited neurogenic capacity. While there are no substantial changes after one mild TBI, r

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Mitchell, Damon John, and n/a. "Phase-reset and effects of ethanol in non-verbal working memory tasks : is there a homologue of hippocampal theta in the human EEG." University of Otago. Department of Psychology, 2009. http://adt.otago.ac.nz./public/adt-NZDU20090309.150949.

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Anxiety disorder is prevalent and costly. But its diagnosis is underdeveloped and treatment ad hoc. This could be corrected if the neural mechanisms of anxiety were known. All anxiolytic medications produce a decrease in rodent hippocampal theta rhythm - so hippocampal theta could underlie some types of anxiety. But, a review (Chapter 2) showed that ethanol and other anxiolytics increase FM-theta in the human scalp EEG and have other properties unlike hippocampal theta. The experiments in this thesis, therefore, tested for other potential homologues (Chapter 3) of hippocampal theta in the huma

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Hunter, Russell I. "Improving associative memory in a network of spiking neurons." Thesis, University of Stirling, 2011. http://hdl.handle.net/1893/6177.

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In this thesis we use computational neural network models to examine the dynamics and functionality of the CA3 region of the mammalian hippocampus. The emphasis of the project is to investigate how the dynamic control structures provided by inhibitory circuitry and cellular modification may effect the CA3 region during the recall of previously stored information. The CA3 region is commonly thought to work as a recurrent auto-associative neural network due to the neurophysiological characteristics found, such as, recurrent collaterals, strong and sparse synapses from external inputs and plastic

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Taylor, Chanel Jayne, and n/a. "Secreted amyloid precursor protein-alpha modulates hippocampal long-term potentiation, in vivo." University of Otago. Department of Psychology, 2008. http://adt.otago.ac.nz./public/adt-NZDU20081217.144344.

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Alzheimer�s disease (AD) is a neurodegenerative disorder, charaeterised by progressive loss of memory. It is important to understand what factors initiate the onset of AD so that effective therapeutic treatments can be developed to target the precise mechanisms that initiate this disease. Currently, synaptic dysfunction is widely believed to be the first significant alteration preceding the onset of AD, and is thought to be initiated by an intracellular accumulation of amyloid-β (Aβ), or a free radical-induced increase of oxidative stress. As Aβ levels rise during the onset of AD, a concomitan

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Edler, Melissa. "A comparative analysis of hippocampus size and ecological factors in primates." [Kent, Ohio] : Kent State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1184945831.

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Thesis (M.A.)--Kent State University, 2007.<br>Title from PDF t.p. (viewed March 27, 2008). Advisor: Chet C. Sherwood. Keywords: hippocampus, spatial memory, diet, habitat, home range, activity pattern, primate, independent contrast. Includes bibliographical references (p. 67-89).

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Elgh, Eva. "Neuropsychological Function in Relation to Structural and Functional Brain Changes in Alzheimer’s Disease." Doctoral thesis, Umeå universitet, Geriatrik, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-323.

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The aim of this doctoral thesis was to study neuropsychological function in relation to structural and functional brain changes in Alzheimer´s disease (AD). In the first study relations between hippocampal volume, neuropsychological function and limbic-hypothalamic-pituitary-adrenal (LHPA) axis disturbances in AD were investigated with magnetic resonance imaging (MRI). Reduced hippocampal CA1 volume and suppressed cortisol levels in combination, best predicted the variation in neuropsychological performance. The conclusion was that reduced hippocampal volume and LHPA axis disturbances are asso

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Dörfel, Denise. "Functional Investigations into the Recognition Memory Network, its Association with Genetic Polymorphisms and Implications for Disorders of Emotional Memory." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-39423.

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Recent research, that has been focused on recognition memory, has revealed that two processes contribute to recognition of previously encountered items: recollection and familiarity (Aggleton & Brown, 1999; Eichenbaum, 2006; Eichenbaum, Yonelinas, & Ranganath, 2007; Rugg & Yonelinas, 2003; Skinner & Fernandes, 2007; Squire, Stark, & Clark, 2004; Wixted, 2007a; Yonelinas, 2001a; Yonelinas, 2002). The findings of neural correlates of recollection and familiarity lead to the assumption that there are different brain regions activated in either process, but there are, to the best of my knowledge,

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48

Allerborn, Marina. "Recent and remote episodic-like memory : characteristics and circuits : approach via multi-site recordings of oscillatory activity in rat hippocampal and cortical brain regions." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1207.

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La mémoire épisodique, notre capacité de se rappeler des épisodes particuliers de notre vie, a été initialement définie chez l'homme en termes de l'information qu'elle contient, quel événement a eu lieu, où et dans quel contexte /quand s'est-il produit? La démonstration de l'existence de cette forme de mémoire chez l'animal a été réalisée chez le geais buissonnier. En effet, cet oiseau cacheur est capable de former une représentation mentale complexe du type de nourriture qu'il a caché, où et quand. Cette forme de mémoire qualifiée d' « episodic-like » a depuis une dizaine d'année été établie

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49

Bett, David. "An investigation of the postsubiculum's role in spatial cognition." Thesis, University of Stirling, 2011. http://hdl.handle.net/1893/6659.

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The hippocampal formation has been implicated in spatial formation for many decades. The hippocampus proper has received the most attention but other regions of the hippocampal formation contribute largely to spatial cognition. This thesis concentrated on one such region, the postsubiculum. The postsubiculum is considered important because it contains head direction cells and because it thought to be a major input to the hippocampus, via the entorhinal cortex. This thesis aims to test the functional role of the rat postsubiculum under two types of situation: one where the rat must rely on idio

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Frazier, Hilaree N. "Exploring the Role of Insulin Receptor Signaling in Hippocampal Learning and Memory, Neuronal Calcium Dysregulation, and Glucose Metabolism." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacol_etds/32.

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In the late 90’s, emerging evidence revealed that the brain is insulin-sensitive, highlighted by broad expression of brain-specific insulin receptors and reports of circulating brain insulin. Contemporary literature robustly supports the role of insulin signaling in normal brain function and suggests that insulin-related processes diminish with aging, evidenced by decreased signaling markers, reduced insulin receptor density, and lower levels of insulin transport across the blood-brain barrier. In the context of pathological cognitive decline, clinical trials using intranasal insulin delivery

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