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Journal articles on the topic 'Hippocratea africana extract'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Ndem, JI, AF Uwah, BO Effiong, UE Bassey, BM Umanah, and CP Chukwudike. "Ethanol leaf extract of Jatropha tanjorensis ameliorates hepatorenal toxicity of Plasmodium berghi-berghi infected mice treated with Hippocratea africana root bark extract." Journal of Phytopharmacology 9, no. 5 (2020): 374–77. http://dx.doi.org/10.31254/phyto.2020.9515.

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The effect of ethanol leaf extract of Jatropha tanjorensis on hepatorenal function of Plasmodium berghiberghi infected mice treated with root bark extract of Hippocratea africana was evaluated. Twenty-One (21) male mice weighing between 27 – 33 g used for the study were divided into seven groups. Group 1 served as normal control while Groups 2 – 7 were parasitized with Plasmodium berghi-berghi and Group 2 was the test control group (parasitized without treatment). Group 3 was administered 8 mg/kg bw of artemether-lumefantrine for 3 days. Group 4 and 5 received daily, 200 mg/kg bw and 300 mg/kg

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2

A., D. Folawewo, N. Madu A., V. Agbaje-Daniels F., O. Faboyede A., and R. Coker A. "Phytochemical Screening and Antibacterial Activities of the Root Bark Extracts of Hippocratea africana (Willd.) Loes. ex Engl." European Journal of Medicinal Plants 19, no. 1 (2017): 1–8. https://doi.org/10.9734/EJMP/2017/32765.

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The root of <em>Hippocratea africana</em> (Celastraceae) is used in ethnomedicine in South-Western Nigeria to treat infectious and parasitic diseases. This study aimed at identifying the compound(s) that are responsible for the antimicrobial activities of the roots and also to contribute to the chemistry of the plant species. Investigation of the phytochemical constituents and antimicrobial activity of the n-hexane and methanol root bark extracts of <em>Hippocratea africana </em>was carried out. These extracts were subjected to screening of preliminary phytochemical test, which showed the pres

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3

Oboho, D. E., P. M. E. Ubulom, I. O. Aguzie, P. E. Umoh, and K. R. Okokon. "Larvicidal efficacy of methanol leaf extracts of Hippocratea africana WILD and Lasianthera africana P. BEAUV against Anopheles gambiae (Diptera:Culicidae)." Dutse Journal of Pure and Applied Sciences 9, no. 1b (2023): 45–52. http://dx.doi.org/10.4314/dujopas.v9i1b.5.

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Developing potent adulticidal and larvicidal products for mosquito control remains a major control strategy for several mosquito-borne parasitic disease. The bio-efficacy of Hippocratea africana and Lasianthera africana methanol leaf extracts were assessed against the larvae of Anopheles gambiae. Plant extracts were shade dried at room temperature and powdered coarsely. Extracts concentrations used for larvicidal bioassays were 0.15, 0.30, 0.45, 0.60 and 0.75 w/v. Observations were made after 24, 48 and 72 h of exposure. The LC50 and LC90 of L. africana and H. africana against the larval of An

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4

Joseph, Oyepata, Jude Okokon, and Jude Okokon. "Hepatoprotective activity of ethanol root extract and fractions of Hippocratea africana against doxorubicin-induced liver toxicity." Journal of Current Biomedical Research 3, no. 4, July-August (2023): 1132–53. http://dx.doi.org/10.54117/jcbr.v3i4.6.

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Doxorubicin (DOX) is an anthracycline glycoside antibiotic with high efficacy against various forms of cancer, whose clinical usefulness has been limited by associated undesirable organs toxicities such as cardiomyopathy, nephrotoxicity and hepatotoxicity despite its high therapeutic index. Hippocratea africana root used locally in the treatment of poisoning was evaluated for antidotal potentials against DOX-induced liver toxicity in rats. Hippocratea africana ethanol root extract as well as dichloromethane and aqueous fractions were evaluated for hepatoprotective activity against doxorubicin-

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5

Johnny, I. I., Okokon, J. E., Ochigbo, E. B., Udo, I. J., and Adefabi, A. M. "Genotoxic and Cytotoxic Activities of Hippocratea africana Loes. Ex. Engl. Celastraceae Root Extract." Asian Journal of Biochemistry, Genetics and Molecular Biology 15, no. 2 (2023): 38–45. http://dx.doi.org/10.9734/ajbgmb/2023/v15i2331.

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Hippocratea africana, a medicinal plant, used in ethnomedicine for the treatment of antimalarial, diabetes, poisoning and inflammatory diseases was investigated for cytotoxic and genotoxic effects on the root meristem cells of Allium cepa. The extract and fractions was also screened for total flavonoid and phenol content using standard methods. Onion bulbs were exposed to 2.5 mg/ml, 5mg/ml, and 10 mg/ml concentrations of the leaf extract for macroscopic and microscopic analysis. Tap water was used as a negative control and Methotrexate (0.1 mg/ml) as a positive control. There was statistically

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6

A., Edagha Innocent, Usoh Itoro F., Akpan Henry D., and Timothy Harrison C. "Hepato-Renal Toxicity Following Administration of Hippocratea africana Ethanolic Leaf Extract." International Journal of Sciences Volume 7, no. 2018-12 (2018): 1–7. https://doi.org/10.5281/zenodo.3350494.

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Hippocratea africana (HA) extract has been widely reported for its anti-plasmodial and antioxidant activites. This study was designed to investigate the plants' ethanolic leaf extract on the liver and renal functions, and histology in experimental animal model. Fifteen female adult Wistar rats weighing 150 - 160 g were divided into 3 groups (A - C) of 5 rats each. Group A, the normal control received distilled water 4 ml/ kg body weight, groups B and C received HA extract (524.4 and 786.6 mg/kg body weights respectively); representing 20% and 30% of LD50 which was 2622.2 mg/kg body weight. Ext

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7

Noah, Kufre U., John A. Udobang, Jude E. Okokon, Martin O. Anagboso, and Nwakaego Omonigho Ebong. "Nephroprotective Activities of Ethanol Root Extract and Fractions of Hippocratea africana Against Doxorubicin-Induced Kidney Toxicity." Biology, Medicine, & Natural Product Chemistry 12, no. 2 (2023): 477–84. http://dx.doi.org/10.14421/biomedich.2023.122.477-484.

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Hippocratea africana root used locally in the treatment of poisoning was investigated to confirm its antidotal potential in rats. The root extract (200-600 mg/kg) and fractions; dichloromethane (DCM) and aqueous, 400 mg/kg) were evaluated for nephroprotective activity against doxorubicin-induced kidney injury in rats. Kidney function parameters, kidney oxidative stress markers and kidney histology were used to assess the kidney protective effect of the extract. The root extract and fractions (200-600 mg/kg) significantly (p<0.05-0.01) reduced the levels of creatinine, urea and electrolytes

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8

Noah, Kufre, Martin O. Anagboso, Uchechukwu L. Iyanyi, Daniel L. Ajaghaku, and Jude E. Okokon. "Hippocratea africana Root Extract and Fractions Ameliorates Paracetamol (PCM)-Induced Oxidative Stress and Liver Injuries in Rats." Asian Journal of Biochemistry, Genetics and Molecular Biology 15, no. 3 (2023): 114–22. http://dx.doi.org/10.9734/ajbgmb/2023/v15i3344.

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Aim: The antidotal potential of Hippocratea africana root, which is used locally to cure poisoning, was studied in rats. Methodology: The hepatoprotective activity of the root extract (200-600 mg/kg), fractions (dichloromethane (DCM) and aqueous, 400 mg/kg) and Silymarin (100 mg/kg), were investigated against paracetamol-induced liver injury in rats. Assay of liver function parameters, markers of antioxidative stress in addition to liver histological analysis were employed to evaluate the hepatoprotective potential of root extract and fractions. Results: Administration of the root

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9

Obioha Kennedy Chinonye, Elizabeth Obioma Nweke, Iheukwumere Barry Chinedu, and Chijioke Ikejiaku. "Anti-Plasmodium berghei activity of Ethanol root bark extract of Hippocratea africana." Open Access Research Journal of Biology and Pharmacy 7, no. 2 (2023): 033–37. http://dx.doi.org/10.53022/oarjbp.2023.7.2.0014.

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Drug resistance is the major challenge that has undermined the viability of the synthetic anti-malaria drugs. The active ingredients inherent in plants are distributed to the various parts which can only be explored based on available information on them. Thus, the aim of this study was to evaluate the anti-plasmodium berghei activity of ethanol root bark extract of Hippocratea Africana. Freshly harvested root bark of H. Africana was dried at room temperature and afterwards ground into fine powder. 500 g of the powdered plant sample was extracted. Twenty five adult mice were divided into five

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10

A. Edagha, Innocent, Itoro F. Usoh, Henry D. Akpan, and Harrison C. Timothy. "Hepato-Renal Toxicity Following Administration of Hippocratea africana Ethanolic Leaf Extract." International Journal of Sciences 4, no. 12 (2018): 1–7. http://dx.doi.org/10.18483/ijsci.1819.

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11

Eseyin, Olorunfemi Abraham, Iweh Emmanuel Etim, Emmanuel E. Attih, et al. "In vitro antiplasmodial, cytotoxic and antioxidant effects, and phytochemical constituents of eleven plants used in the traditional treatment of malaria in Akwa Ibom State, Nigeria." Tropical Journal of Pharmaceutical Research 20, no. 1 (2021): 105–11. http://dx.doi.org/10.4314/tjpr.v20i1.16.

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Purpose: To evaluate the antiplasmodial effects of eleven plants (Bombax buonopozense, Carica papaya, Anthocleista djalonensis, Milicia excelsa, Heterotis rotundifolia, Homalim letestui, Starchystarpheta cayennnensis, Ocimum gratissimum, Cleistopholis patens, Chromolaena odorata and Hippocratea africana) reportedly used in the treatment of malaria in Akwa Ibom State of Nigeria. Methods: Phytochemical analysis was done by standard methods, while in vitro antiplasmodial evaluation was carried out using Plasmodium falciparum chloroquine-sensitive and chloroquineresistant strains using lacta

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12

Uwah AF, Effiong BO, Obot JS, Obioku IJ, and Udoh AE. "Therapeutic potential of concurrent administration of Hippocratea africana and Eremomastax speciosa in the treatment of Plasmodium berghei infected mice." Ibom Medical Journal 15, no. 2 (2022): 166–74. http://dx.doi.org/10.61386/imj.v15i2.255.

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Context: Despite the commonness of polyherbal therapy among the locals in the treatment of malaria in Nigeria, there are no adequate data on the therapeutic potentials and safety profile of these herbal combinations. The use of these plants in combination in the treatment of suspected and confirmed malaria infection is very common among the Niger Delta dwellers in Nigeria. Aim: To evaluate the therapeutic potential of co-administration of Hippocratea Africana, a medicinal plant with well documented antimalarial properties, and Eremomastax speciosa, a tropical plant with well reported ant

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13

Oboho, Diligent Efiong, Rosemary Anietie Essien, Emem Okon Mbong, et al. "Toxic Effects of Methanolic Extracts of Plants Leaves on the Mortality and Enzymatic Parameters of Callosobruchus maculatus Fab. (Coleoptera: Bruchidae) Juveniles." Asian Journal of Research in Zoology 6, no. 2 (2023): 1–10. http://dx.doi.org/10.9734/ajriz/2023/v6i2106.

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This study was conducted in the laboratory to evaluate the effect of leaves extract of three botanicals on the biochemical parameters of insect pest of stored beans, Callosobruchus maculatus. The results of the qualitative phytochemicals revealed the presence of different metabolites such as tannins, saponins, cardiac glycosides, phenolic compounds, flavonoids, alkaloids etc. The toxic effect of methanolic leaves extracts of Lasianthera africana, Hippocratea africana and Uvaria chamae on the mortality and biochemical parameters after treatment against C. maculatus was evaluated. The result sho

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14

Okokon, Jude E., Bassey S. Antia, and Emem Umoh. "Analgesic and Anti-Inflammatory Effects of Ethanolic Root Extract of Hippocratea africana." International Journal of Pharmacology 4, no. 1 (2007): 51–55. http://dx.doi.org/10.3923/ijp.2008.51.55.

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15

Noah, Kufre U., and Jude E. Okokon. "Hippocratea africana Ethanol Root Extract and Fractions Attenuate Doxorubicin-Induced Testicular Toxicity and Oxidative Stress." Biology, Medicine, & Natural Product Chemistry 13, no. 2 (2024): 397–406. http://dx.doi.org/10.14421/biomedich.2024.132.397-406.

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Hippocratea africana root, used locally in treating poisoning, was investigated to confirm its antidotal potential in rats. The root extract (200-600 mg/kg) and fractions; dichloromethane (DCM) and aqueous, 400 mg/kg) were evaluated for hepatoprotective activity against doxorubicin-induced testicular toxicity in male rats. Testosterone level, lipid profile indices, testicular oxidative stress markers, and testis histology were used to assess the testicular protective effect of the extract. The root extract (200-600 mg/kg) and fractions, dichloromethane (DCM) and aqueous, 400 mg/kg reduced the

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16

Okokon, Jude E., Martin O. Anagboso, and Kufre U. Noah. "Hippocratea africana Root Extract and Fractions Attenuated Carbon Tetrachloride-Induced Oxidative Stress and Liver Injuries in Rats." Journal of Complementary and Alternative Medical Research 25, no. 8 (2024): 71–83. http://dx.doi.org/10.9734/jocamr/2024/v25i8561.

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Hippocratea africana root is used locally in ethnomedicine to treat various diseases such as diabetes, malaria and poisoning. This work aimed to investigate the antidotal potential of the root extract and fractions against carbon tetrachloride induced liver injury to justify its ethnomedicinal uses and give scientific proof to its claimed antidotal activity in traditional medicine. Therefore, 40 rats were randomly divided into eight (8) groups of 5 rats each and treated as follows: Group 1- (normal control) received oral 10 mL/kg of distilled water, Group 2- served as the organotoxic group, gr

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17

Ndem, Jessie Idongesit, and Victor Eno Johnson. "Testosterone Concentration and Testicular Histomorphology of Rats Exposed to Hippocratea Africana Root Bark Extract." IOSR Journal of Pharmacy and Biological Sciences 12, no. 02 (2017): 13–17. http://dx.doi.org/10.9790/3008-1202011317.

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18

Ndem, Jessie, and Efosa Ewere. "Comparative Hepatic Effects of Hippocratea africana Root Bark Extract on Female and Male Albino Wistar Rats." British Journal of Pharmaceutical Research 9, no. 3 (2016): 1–11. http://dx.doi.org/10.9734/bjpr/2016/22379.

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19

Idongesit, Ndem, Jessie, and David, Imoh Kingsley. "Biochemical Indices of Cardaic Function of Albino Wistar Rats Exposed to Hippocratea Africana Root Bark Extract." IOSR Journal of Biotechnology and Biochemistry 03, no. 01 (2017): 101–6. http://dx.doi.org/10.9790/264x-0301101106.

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20

em, Nd, Jessie Idongesit, Bas sey, and Eno-Obong Ikpeme. "Effect of Hippocratea africana Root Bark Extract on the Pituitary-Gonadal Hormones of Female Wistar Rats." International Journal of Medical Science 4, no. 6 (2017): 1–7. http://dx.doi.org/10.14445/23939117/ijms-v4i6p101.

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21

Ndem, J., M. Eteng, and A. Uwah. "Effect of Hippocratea africana Root Bark Extract on Lipid Profile of Female and Male Albino Wistar Rats." Journal of Scientific Research and Reports 3, no. 19 (2014): 2574–83. http://dx.doi.org/10.9734/jsrr/2014/12491.

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22

Idongesit Ndem, Jessie, Eno-Obong Ikpeme Bassey, Blessing Obinaju Effiong, Utibe Evans Bassey, and Sylvester Daniel Ini. "Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in <i>Plasmodium berghi-berghi</i> Infected Mice Treated with <i>Hippocratea africana</i> Root Bark Extract." Journal of Diseases and Medicinal Plants 5, no. 4 (2019): 69. http://dx.doi.org/10.11648/j.jdmp.20190504.12.

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23

Folawewo, A., A. Madu, F. Agbaje-Daniels, A. Faboyede, and A. Coker. "Phytochemical Screening and Antibacterial Activities of the Root Bark Extracts of Hippocratea africana (Willd.) Loes. ex Engl." European Journal of Medicinal Plants 19, no. 1 (2017): 1–8. http://dx.doi.org/10.9734/ejmp/2017/32765.

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24

NOAH, KUFRE, UTIBE A. EDEM, UCHECHUKWU L. IYANYI, DANIEL L. AJAGHAKU, and JUDE E. OKOKON. "Hippocratea africana root extract and fractions ameliorated carbon tetrachloride-induced oxidative stress and kidney injuries in rats." Asian Journal of Natural Product Biochemistry 22, no. 2 (2024). https://doi.org/10.13057/biofar/f220201.

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Abstract. Noah K, Edem UA, Iyanyi UL, Ajaghaku DL, Okokon JE. 2024. Hippocratea africana root extract and fractions ameliorated carbon tetrachloride-induced oxidative stress and kidney injuries in rats. Asian J Nat Prod Biochem 22: 51-58. A common cause of renal failure with potential side effects is drug-induced nephrotoxicity. Renal damage in experiments is frequently induced chemically using carbon tetrachloride (CCl4), a well-known environmental contaminant with nephrotoxic effects. Intoxicated animals to CCl4 experience experimental oxidative stress in various physiological conditions tha

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25

Nwakaego, Ebong. "Hippocratea africana root extract and fractions attenuate paracetamol-induced oxidative stress and kidney injuries in rats." Journal of Current Biomedical Research 3, no. 4, July-August (2023). http://dx.doi.org/10.54117/jcbr.v3i4.2.

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Hippocratea africana root used locally in the treatment of poisoning was investigated to confirm its antidotal potential in rats. The root extract (200-600 mg/kg) and fractions; dichloromethane (DCM) and aqueous, 400 mg/kg) were evaluated for nephroprotective activity against paracetamol-induced kidney injury in rats. Anti-oxidative stress and renoprotective potentials of root extract and fractions were assessed by determining oxidative stress markers levels, kidney function parameters and histopathology in rats. The root extract and fractions caused significant (p<0.05 – 0.001) increases i

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26

Ndem, Jessie Idongesit. "PARASITAEMIA REDUCTION AND MODERATELY IMPROVED HAEMATOLOGICAL INDICES POTENTIALS OF HIPPOCRATEA AFRICANA ROOT BARK EXTRACT IN PLASMODIUM BERGHEIBERGHEI INFECTED MICE." World Journal of Pharmaceutical Research, July 1, 2017, 63–74. http://dx.doi.org/10.20959/wjpr20177-8735.

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