Relevant bibliographies by topics / Hiromi Itō

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Hiromi Itō'

Author: Grafiati
Published: 11 June 2021
Last updated: 8 February 2022

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Journal articles on the topic "Hiromi Itō"

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Morita, Keitaro. "Ecopoeta queer? Uma análise de "Chitô [Tito]", da poeta japonesa Hiromi Ito." Revista Estudos Feministas 19, no. 1 (April 2011): 265–83. http://dx.doi.org/10.1590/s0104-026x2011000100018.

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O conceito de natureza tem sido caracterizado por uma série de dicotomias, como natureza externa/natureza interna e ambiente natural/corpo. De uma forma geral, a crítica ambientalista japonesa tem ignorado o lado direito desses dualismos - natureza interna e corpo. Este trabalho enfoca essas dimensões suprimidas através do exame do ecopoema de Hiromi Ito "Chitô [Tito]", retirado do livro Noro to Saniwa [Noro e Saniwa], que escreveu com Chizuko Ueno. Ao falar sobre natureza interna e corpo, o presente estudo ocupa-se especialmente da sexualidade e da queeridade. Hiromi Ito é perspectivada como uma ecopoeta queer, porque em "Chitô", ao questionar implicitamente a 'naturalidade' da heterossexualidade universal, ela problematiza as fronteiras entre heterossexualidade e homossexualidade, mostra sem inibições sua significação erótica retida do estágio anal pré-edipiano em suas explorações sexuais adultas, assim como uma utopia onanista sadomasoquista (SM) reservada apenas a uma mulher, e trata os homens no poema como sendo meros corpos desmembrados e órgãos sexuais objetificados; mais ainda, sua queeridade encontra outras encorporações significantes em sua recusa de se deixar cair na armadilha de identidades sexuais ou sexualidades fixas. Nesse sentido, este trabalho ilumina as dimensões esquecidas das dicotomias natureza externa/ natureza interna e ambiente natural/corpo em "Chitô".
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SAKAGUCHI, SAKIKO ORUI, and HIROSHI UEDA. "A new species closely related to Acartia sinjiensis (Copepoda: Calanoida), from river estuaries of northern Luzon, the Philippines." Zootaxa 4881, no. 3 (November 20, 2020): 532–44. http://dx.doi.org/10.11646/zootaxa.4881.3.6.

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We describe a brackish-water calanoid copepod Acartia (Acanthacartia) cagayanensis sp. nov. collected from river estuaries in the northernmost Luzon, the Philippines. The new species has several characteristic features that are typical to the A. plumosa group (A. (A.) plumosa Scott T., 1894, A. (A.) sinjiensis Mori, 1940 and A. (A.) tropica Ueda & Hiromi, 1987); specifically, a short apical spine on the long terminal segment of male left leg 5, which is unique to the group. The morphological features of A. cagayanensis sp. nov. different from those of the A. plumosa group are the barrel-shaped genital double somite and the cylindrical basal part of the terminal segment of female leg 5. Among the species in the group, A. cagayanensis sp. nov. is closest to A. sinjiensis in terms of the spinule patterns on the female antennule, the posterior corner of the prosome, and the male second urosomite. The genetic analysis using DNA sequences of mitochondrial gene cytochrome oxidase subunit I (COI) revealed that A. sinjiensis from Japan and A. cagayanensis sp. nov. differed by 16.5–16.9%, in contrast to a small variation (0.0–0.5%) within each population. We confirmed that previous records of A. sinjiensis from the Philippines were not A. cagayanensis sp. nov., and therefore, A. cagayanensis sp. nov. is the third species of the subgenus Acanthacartia Steuer, 1925, after A. sinjiensis and A. (A.) tsuensis Ito, 1956.
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SAKAMOTO, K. "Ito Hirobumi to Kankoku Tochi (Ito Hirobumi and Japanese Rule in Korea)." Social Science Japan Journal 14, no. 2 (April 2, 2011): 259–61. http://dx.doi.org/10.1093/ssjj/jyr006.

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Goto, Hiromi. "Cross-Cultural Creatures: Hiromi Goto Brings Magic into Everyday Life." Women's Review of Books 19, no. 10/11 (July 2002): 17. http://dx.doi.org/10.2307/4023885.

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Ma, Wen-Xiu, Jie Li, and Chaudry Masood Khalique. "A Study on Lump Solutions to a Generalized Hirota-Satsuma-Ito Equation in (2+1)-Dimensions." Complexity 2018 (December 2, 2018): 1–7. http://dx.doi.org/10.1155/2018/9059858.

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The Hirota-Satsuma-Ito equation in (2+1)-dimensions passes the three-soliton test. This paper aims to generalize this equation to a new one which still has abundant interesting solution structures. Based on the Hirota bilinear formulation, a symbolic computation with a new class of Hirota-Satsuma-Ito type equations involving general second-order derivative terms is conducted to require having lump solutions. Explicit expressions for lump solutions are successfully presented in terms of coefficients in a generalized Hirota-Satsuma-Ito equation. Three-dimensional plots and contour plots of a special presented lump solution are made to shed light on the characteristic of the resulting lump solutions.
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Niu, Xiaoxing, Mengxia Zhang, and Shuqiang Lv. "A Darboux Transformation for Ito Equation." Zeitschrift für Naturforschung A 71, no. 5 (May 1, 2016): 427–31. http://dx.doi.org/10.1515/zna-2016-0004.

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AbstractA system proposed by Ito is reconsidered. The corresponding Darboux transformation is presented explicitly. The resulted Bäcklund transformation is shown to be equivalent to the one found by Hirota. Also, a nonlinear superposition formula, which is of differential-algebraic, is obtained.
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Shen, Wang, Zhengyi Ma, Jinxi Fei, and Quanyong Zhu. "Novel characteristics of lump and lump–soliton interaction solutions to the (2+1)-dimensional Alice–Bob Hirota–Satsuma–Ito equation." Modern Physics Letters B 34, no. 36 (August 25, 2020): 2050419. http://dx.doi.org/10.1142/s0217984920504199.

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Based on the Hirota bilinear method and symbolic computation, abundant exact solutions, including lump, lump–soliton, and breather solutions, are computed for the coupled Alice–Bob system of the Hirota–Satsuma–Ito equation in (2 + 1)-dimensions. The three-dimensional figures of these solutions are presented, which illustrate the characteristics of these solutions.
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Yu, Jian-Ping, Wen-Xiu Ma, Chaudry Masood Khalique, and Yong-Li Sun. "Localized interaction solution and its dynamics of the extended Hirota–Satsuma–Ito equation." Modern Physics Letters B 35, no. 19 (May 10, 2021): 2150313. http://dx.doi.org/10.1142/s0217984921503139.

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In this research, we will introduce and study the localized interaction solutions and their dynamics of the extended Hirota–Satsuma–Ito equation (HSIe), which plays a key role in studying certain complex physical phenomena. By using the Hirota bilinear method, the lump-type solutions will be firstly constructed, which are almost rationally localized in all spatial directions. Then, three kinds of localized interaction solutions will be obtained, respectively. In order to study the dynamic behaviors, numerical simulations are performed. Two interesting physical phenomena are found: one is the fission and fusion phenomena happening during the procedure of their collisions; the other is the rogue wave phenomena triggered by the interaction between a lump-type wave and a soliton wave.
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Ma, Hongcai, Xiangmin Meng, Hanfang Wu, and Aiping Deng. "A class of lump solutions for ito equation." Thermal Science 23, no. 4 (2019): 2205–10. http://dx.doi.org/10.2298/tsci1904205m.

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In this paper, we investigate the exact solutions for the (1+1)-D Ito equation. Some lump solutions are obtained by using Hirota?s bilinear method, and the conditions to guarantee analytical and rational localization of the lump solutions are presented. Suitable choices of the involved parameters guaranteeing analyticity of the solution are given. The 3-D plots with particular choices of the involved parameters are illustrated.
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Hyun, Kwang Ho. "Perception on Ito Hirobumi of the France in the Residency-General Period." Historical Association for Soong-Sil 40 (June 30, 2018): 157–86. http://dx.doi.org/10.16942/ssh.2018.40.6.05.

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Dissertations / Theses on the topic "Hiromi Itō"

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Davidsson, Matilda. "Grieving the Ungrievable: Searching for Home through Nonhuman Becoming in Hiromi Itō’s Wild Grass on the Riverbank and Elizabeth-Jane Burnett’s The Grassling." Thesis, Linnéuniversitetet, Institutionen för språk (SPR), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-104195.

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This thesis aims to examine non-human agency in Elizabeth Jane Burnett’s The Grassling and Hiromi Itō’s Wild Grass on the Riverbank. Using a theoretical framework based on material ecocriticism, queer ecology and affect theory, the thesis explores how Burnett’s and Itō’s poetic narratives reconfigure the relationship between human and nonhuman in non-anthropocentric ways with the help of the irreal. The thesis discusses how the texts reimagine desire, moving from a Freudian view in which desire is repressed, to an understanding of desire as becoming as expressed by Deleuze. In the stories, humans metamorphose into plants, showing the interconnectedness of all matter and the importance of care exceeding species. These strands of the narratives contest anthropocentrism, and by extension also the heteropatriarchy to which it is related. Grief over traumatic experiences like family loss and migration in the stories are shown to be related to the loss of a planetary home as a result of climate change.
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Otomo, Kanako [Verfasser], Manfred [Akademischer Betreuer] Kössl, Hiroshi [Akademischer Betreuer] Ito, Jochen [Akademischer Betreuer] Roeper, Manfred [Gutachter] Kössl, Gilles [Gutachter] Laurent, Amparo [Gutachter] Acker-Palmer, and Henner [Gutachter] Hollert. "Exploring the in vivo subthreshold membrane activity of phasic firing in midbrain dopamine neurons / Kanako Otomo ; Gutachter: Manfred Kössl, Gilles Laurent, Amparo Acker-Palmer, Henner Hollert ; Manfred Kössl, Hiroshi Ito, Jochen Roeper." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2021. http://nbn-resolving.de/urn:nbn:de:hebis:30:3-613882.

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Books on the topic "Hiromi Itō"

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Moshiogusa: Ino Hiroya jijoden : denki Ino Hiroya. Tōkyō: Ōzorasha, 2000.

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Kumar, Sivasubramanian, ed. Hiroki Endo's tanpenshu. Milwaukie, OR: Dark Horse Manga, 2007.

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It'o Hirobumi wa Taehan Cheguk. Sŏul-si: Kkach'i, 2015.

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4

Hiroshi, Sekine. Cinderellas: The selected poetry of Sekine Hiroshi = "Shinderera" Eiyaku Sekine Hiroshi shū. Stanwood, WA: Yakusha, 1995.

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Itō, Takatoshi. Efficiency of the Tokyo housing market / Takatoshi Ito, Keiko Nosse Hirono. Cambridge, MA: National Bureau of Economic Research, 1993.

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6

It'o Hirobumi ŭi Han'guk pyŏnghap kusang kwa Chosŏn sahoe. Kyŏnggi-do P'aju-si: Yŏllin Ch'aektŭl, 2012.

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Ichikyūrokukyū Shinjuku Nishiguchi Chika Hiroba. Tōkyō: Shinjuku Shobō, 2014.

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8

Tong-sŏng, Cho, and Kim Sŏng-min 1980-, eds. It'o Hirobumi, An Chung-gŭn ŭl ssoda: Tanp'yŏn yŏksa sosŏl. Sŏul T'ŭkpyŏlsi: IWELL, 2009.

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9

Hisae, Sawachi. Yuki wa yogorete ita: Shōwa shi no nazo Nīnīroku Jiken saigo no hiroku. Tōkyō: Nihon Hōsō Shuppan Kyōkai, 1988.

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Sakutarō, Hagiwara. Howling at the moon: Poems and prose of Hagiwara Sakutarō ; translated from the Japanese, with an introduction, by Hiroaki Sato. Københaven: Green Integer, 2002.

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Book chapters on the topic "Hiromi Itō"

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Morita, Keitaro. "A Queer Ecofeminist Reading of “Matsuri [Festival]“ by Hiromi Ito." In East Asian Ecocriticisms, 59–73. New York: Palgrave Macmillan US, 2013. http://dx.doi.org/10.1057/9781137345363_4.

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Verma, Pallavi, and Lakhveer Kaur. "Bilinearization and Analytic Solutions of $$(2+1)$$-Dimensional Generalized Hirota-Satsuma-Ito Equation." In Advances in Intelligent Systems and Computing, 235–44. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-5414-8_19.

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Cucinelli, Diego. "幻の春の声. 近現代日本文学における「亀鳴く」/ The illusory voice of the spring: the motif of ‘crying turtle’ in modern and contemporary Japanese literarure." In Studi e saggi, 29–50. Florence: Firenze University Press, 2020. http://dx.doi.org/10.36253/978-88-5518-260-7.02.

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The turtle (kame) is of great importance in East Asian culture and it is seen as a supernatural creature. In Japanese literature, we can find examples of the turtle in works dating back to the Nara period, such as Tangokuni fudoki and Nihonshoki. Just like the crane, the turtle is a symbol of longevity. However, from the Kamakura period a new and unique interpretation of the turtle as the “singing/crying turtle” makes its appearance. Of this topos, known as kame naku, we can find only very few examples in literature until the Meiji era and the most known are the waka anthologies Shinsen waka rokujō and Fuboku wakashō, and Kyokutei Bakin’s kigo collection Haikai saijiki shiorigusa. However, from the beginning of the modern age, kame naku has been used by many poets as a kigo connected to spring and its frequency has hugely increased. After the war, it began to appear not only in poetry but also in novels and essays. The best known examples of this being Mishima Yukio’s short novel Chūsei, Uchida Hyakken’s essay Kame naku ya, Kawakami Hiromi’s work Oboreru. Using kame naku as a keyword, in this paper we will analyze the attitudes and approaches of modern and contemporary poets and novelists toward the topos.
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"Mental health policy and services: where we stand: Hiroto Ito." In Mental Health Care in Japan, 53–73. Routledge, 2012. http://dx.doi.org/10.4324/9780203098349-9.

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Colson, Robin, and Atsusi Hirumi. "A Framework for the Design of Online Competency-Based Education to Promote Student Engagement." In Student Engagement and Participation, 203–20. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-2584-4.ch010.

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Advances in technology offer opportunities for many varieties of online learning but much online learning design is based on past practices and technologies (Hirumi, 2013). This practice could prove to be particularly detrimental for competency-based education (CBE) given its unique profile as a form of online learning that is self-driven and asynchronous. Furthermore, the majority of CBE students in higher education are non-traditional adult learners who require a high level of support and engagement from their educational experiences. One instructional technique that has proven to be effective for promoting student engagement in online learning is interaction (Wang, Chen, & Anderson, 2014; Hirumi, 2006; Anderson, 2003). This chapter draws from Hirumi's (2002, 2006, 2013) framework for designing interaction in online learning courses to provide suggestions for creating online CBE instruction that engages and motivates non-traditional students in higher education.
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Colson, Robin, and Atsusi Hirumi. "A Framework for the Design of Online Competency-Based Education to Promote Student Engagement." In Handbook of Research on Competency-Based Education in University Settings, 168–85. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-0932-5.ch009.

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Advances in technology offer opportunities for many varieties of online learning but much online learning design is based on past practices and technologies (Hirumi, 2013). This practice could prove to be particularly detrimental for competency-based education (CBE) given its unique profile as a form of online learning that is self-driven and asynchronous. Furthermore, the majority of CBE students in higher education are non-traditional adult learners who require a high level of support and engagement from their educational experiences. One instructional technique that has proven to be effective for promoting student engagement in online learning is interaction (Wang, Chen, & Anderson, 2014; Hirumi, 2006; Anderson, 2003). This chapter draws from Hirumi's (2002, 2006, 2013) framework for designing interaction in online learning courses to provide suggestions for creating online CBE instruction that engages and motivates non-traditional students in higher education.
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Taber, Douglass F. "Intramolecular Diels-Alder Cycloaddition: 7-Isocyanoamphilecta- 11(20),15-diene (Miyaoka), (–)-Scabronine G (Kanoh), Basiliolide B (Stoltz), Hirsutellone B (Uchiro), Echinopine A (Chen)." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0078.

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The amphilectane diterpenes, exemplified by 7-isocyanoamphilecta-11(20),15-diene 3, have been little investigated. In the course of a synthesis of 3, Hiroaki Miyaoka of the Tokyo University of Pharmacy and Life Sciences took advantage (Synlett 2011, 547) of the kinetic enolization and silylation of 1 to convert it into a trienone that spontaneously cyclized to 2. Scabronine G 6, isolated from the mushroom Sarcodon scabrosus, was found to enhance the secretion of neurotrophic factors from 1321N1 astrocytoma cells. To set the absolute configuration of the two quaternary centers that are 1, 4 on the cyclohexane ring of 6, Naoki Kanoh and Yoshiharu Iwabuchi of Tohoku University cyclized (Org. Lett. 2011, 13, 2864) 4 to 5. Although described by the authors as a double Michael addition, this transformation has the same connectivity as an intramolecular Diels-Alder cycloaddition. The diterpenes isolated from the genus Thapsia, represented by basiliolide B 9, induce rapid mobilization of intracellular Ca2+ stores. Brian M. Stoltz of Caltech effected (Angew. Chem. Int. Ed. 2011, 50, 3688) Claisen rearrangement of 7 to give an intermediate that cyclized to 8 as a mixture of diastereomers. A significant challenge in the synthesis was the assembly of the delicate enol ether/lactone of 9. Hirsutellone B 12, isolated from Hirsutella nivea, shows significant antituberculosis activity. Hiromi Uchiro of the Tokyo University of Science found it useful (Org. Lett. 2011, 13, 6268) to protect the intermediate unsaturated keto ester by intermolecular cycloaddition with pentamethylcyclopentadiene before constructing the triene of 10. Simple thermolysis reversed the intermolecular addition, opening the way to intramolecular cycloaddition to give 11. The tetracyclic ring system of the diterpene echinopine A 15 represents a substantial synthetic challenge. David Y.-K. Chen of Seoul National University approached this problem (Org. Lett. 2011, 13, 5724) by Pd-mediated cyclization of 13 to the diene, which then underwent intramolecular Diels-Alder cycloaddition to give 14, with control of the relative configuration of two of the three ternary centers of 15. Double bond migration followed by oxidative cleavage of the resulting cyclohexenone then set the stage for the intramolecular cyclopropanation that completed the synthesis of 15.
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Allosso, Dan. "Peppermint Bank." In Peppermint Kings, 99–133. Yale University Press, 2020. http://dx.doi.org/10.12987/yale/9780300236828.003.0006.

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This chapter recounts how Hiram Hotchkiss opened his own Peppermint Bank in order to avoid the difficulties he continually had with local bankers. It explains how Hiram used his Peppermint Bank primarily as a payment mechanism for his essential oil business. It also discusses how Hiram spent his money in western New York and in Michigan to pay for oil rather than loan his notes into the local market. The chapter traces back free banking, which was the dominant regulatory system for antebellum banks that has taken too much of the blame for economic instability before the Civil War. It also explains that free banking refers to the ability of banks to be established without legislative charters, but the lack of state charters does not imply that the banks were allowed to print money indiscriminately.
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Ekici, Mustafa, and Metin Ünal. "Application of the Exponential Rational Function Method to Some Fractional Soliton Equations." In Emerging Applications of Differential Equations and Game Theory, 13–32. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-0134-4.ch002.

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In this chapter, the authors study the exponential rational function method to find new exact solutions for the time-fractional fifth-order Sawada-Kotera equation, the space-time fractional Whitham-Broer-Kaup equations, and the space-time fractional generalized Hirota-Satsuma coupled KdV equations. These fractional differential equations are converted into ordinary differential equations by using the fractional complex transform. The fractional derivatives are defined in the sense of Jumarie's modified Riemann-Liouville. The proposed method is direct and effective for solving different kind of nonlinear fractional equations in mathematical physics.
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Nagasaki, Hiroko. "Duality in the Language and Literary Style of Raskhan’s Poetry." In Text and Tradition in Early Modern North India, 159–73. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199478866.003.0008.

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Hiroko Nagasaki looks closely at the poet Raskhan’s signature chands, that is, the metrical forms in which he most frequently composed, focusing in particular on the savaiyā. What she finds is a metrical structure that combined Persian and Indic systems of prosody, allowing different methods of scansion and therefore different stylistic options. This discovery in turn reveals a connection between Raskhan’s poems of Vaishnava bhakti and the highly stylized world of the Persian ghazzal, a form heavily influenced by the idiom of Sufi devotion. These insights into stylistic crossover are especially significant in light of the hagiographical tradition surrounding Raskhan, which claims he was a Muslim who took up devotion to Krishna at some point in adulthood.
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Conference papers on the topic "Hiromi Itō"

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Breedveld, Paul, and Shigeo Hirose. "Development of the Endo-Periscope for Improvement of Depth Perception in Laparoscopic Surgery." In ASME 2001 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/detc2001/dac-21031.

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Abstract Laparoscopic surgery is carried out by using an endoscope with a camera that is inserted through a small incision in the abdominal wall. The camera pictures are presented on a monitor. The light source of the endoscope forms a ring around the camera lens, and the endoscope movements are limited by the incision point. The absence of shadows in the camera picture and the restricted ability to observe organs from aside complicate the surgeon’s depth perception. This paper describes the development of a new steerable endoscope that is the product of a close co-operation between the Man-Machine Systems Group of the Delft University of Technology and the Hirose & Yoneda Laboratory of the Tokyo Institute of Technology. The endoscope, which is called Endo-Periscope, uses a new spatial parallelogram-mechanism to transform the movements of the handgrip into movements of the steerable tip. The handgrip contains an arrow that points always in the direction of the line-of-sight of the tip-camera. This provides intuitive control of the tip and it shows the surgeon how the camera is oriented in the abdominal cavity. The light source is located on the shaft and the tip-camera can be moved in six degrees of freedom. This enables the surgeon to observe organs from different sides and to use shadows as a depth information source. Part of the parallelogram-mechanism is a new kind of spring which combines a very high torsional stiffness with a low, asymmetric bending stiffness. The spring and the working principle of the Endo-Periscope have been applied for two patents.
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Wu, K., C. Manner, and A. Tsai. "CHARACTERIZATION OF SERUM PROSTACYCLIN BINDING DEFECTS IN THROMBOTIC THROMBOCYTOPENIC PURPURA (TTP)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643978.

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To understand further the pathophysiologic significance of PGI2 binding defects in TTP, we measured serum PGI2 binding activity in 12 TTP patients and matched controls. Serum binding of PGI2 was measured by Sephadex G-25 gel filtration. The mean binding activity in 33 healthy subjects ages 20-40 years was 39.9 ± S.D 4.4%. The mean value of TTP (n=12) was significantly lower (26.2 ± 4.1, P <0.01). Serum from 5 severe ITP, 5 DIC and 5 thrombocythemia exhibited normal binding ctivity. To determine the binding kinetics we utilized 3H-iloprost in a gel filtration method described by Hirose and Kano (Biochim. Biophys. Acta. 751:376, 1971). To 50 mg of Sephadex G-50, 0.435 ml of 50mM Tris buffer (pH 7.4) was added. After swelling of the gel was completed 0.195 ml of the buffer solution containing serum and 3H-iloprost was added. The sample was mixed and the protein and ligand concentration was determined. The computer fitting of the binding isotherm according to the originally proposed equation yielded a binding curve consistent with a single class of binding sites. The Kd value of normal serum was 70 μM and the B 48 nmol/ml. Acute TTP serum exhibited a reduced bindingXaffinity (Kd 236 μM) and a slightly elevated capacity (Bmax 85 nmols/ml). The binding parameters improved following successful treatment but the Kd remained subnormal (120 μM). These data indicate that reduced PGI2 binding activity is due to lower affinity of the PGI2 binding proteins. The relationship between defective PGI2 binding activity and PGI2 production was then evaluated. Serial serum and 24 hour urine were collected. Urinary samples were extracted and their 6-Keto-PGF1α (6KP) and thromboxane TXB2 levels were measured by RIA. TTP patients in remission had normal levels of urinary 6KP and TXB2 while urinary 6KP and TXB2 were elevated in relapsing TTP. Defective binding was noted when relapse began to occur while elevated 6KP and TXB2 were noted 48 hrs later. Both 6KP and TXB2 were normalized when the disease was controlled. Our findings indicate that defective PGI2 binding plays an important role in causing excessive platelet activation and platelet-vessel wall interaction in TTP.
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