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Journal articles on the topic 'His95'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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1

Rehl, Kristen M., Jayaraman Selvakumar, Rhonda L. Pitsch, et al. "A new ferrocene derivative blocks K-Ras localization and function by oxidative modification at His95." Life Science Alliance 6, no. 11 (2023): e202302094. http://dx.doi.org/10.26508/lsa.202302094.

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Ras proteins are membrane-bound GTPases that regulate essential cellular processes at the plasma membrane (PM). Constitutively active mutations of K-Ras, one of the three Ras isoforms in mammalian cells, are frequently found in human cancers. Ferrocene derivatives, which elevate cellular reactive oxygen species (ROS), have shown to block the growth of non-small cell lung cancers harboring oncogenic mutant K-Ras. Here, we tested a novel ferrocene derivative on the growth of pancreatic ductal adenocarcinoma and non-small cell lung cancer. Our compound, which elevated cellular ROS levels, inhibit

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2

Gao, Miaomiao, Kaili Nie, Meng Qin, Haijun Xu, Fang Wang та Luo Liu. "Molecular Mechanism Study on Stereo-Selectivity of α or β Hydroxysteroid Dehydrogenases". Crystals 11, № 3 (2021): 224. http://dx.doi.org/10.3390/cryst11030224.

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Hydroxysteroid dehydrogenases (HSDHs) are from two superfamilies of short-chain dehydrogenase (SDR) and aldo–keto reductase (AKR). The HSDHs were summarized and classified according to their structural and functional differences. A typical pair of enzymes, 7α–hydroxysteroid dehydrogenase (7α–HSDH) and 7β–hydroxysteroid dehydrogenase (7β–HSDH), have been reported before. Molecular docking of 7-keto–lithocholic acid(7–KLA) to the binary of 7β–HSDH and nicotinamide adenine dinucleotide phosphate (NADP+) was realized via YASARA, and a possible binding model of 7β–HSDH and 7–KLA was obtained. The α

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3

Viles, John H., Mark Klewpatinond, and Rebecca C. Nadal. "Copper and the structural biology of the prion protein." Biochemical Society Transactions 36, no. 6 (2008): 1288–92. http://dx.doi.org/10.1042/bst0361288.

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PrP (prion-related protein) is a cell-surface Cu2+-binding glycoprotein which, when misfolded, is responsible for a number of transmissible spongiform encephalopathies. The co-ordination geometry, stoichiometry and affinity of Cu2+ for PrP are the subject of much debate. In the present paper, we review the recent progress we have made in these areas. As many as six Cu2+ ions bind to PrP with submicromolar affinity. Initially, two Cu2+ ions bind to full-length PrP in the amyloidogenic region, between the octarepeats and the structured domain, at His95 and His110. Only subsequent Cu2+ ions bind

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4

Yang, Hailong, Lu Gan, and Huabei Zhang. "Design, Synthesis, Anticancer Evaluation and Molecular Docking of Pyrimidine, Pyrido[4,3-d]pyrimidine and 5,6,7,8-Tetrahydropyrido[3,4-d]pyrimidine Derivatives as Novel KRAS-G12D Inhibitors and PROTACs." Pharmaceuticals 18, no. 5 (2025): 696. https://doi.org/10.3390/ph18050696.

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Background: KRAS-G12D mutations drive 20–50% of pancreatic/biliary cancers yet remain challenging to target due to GTP-pocket conservation and high cellular GTP levels. While allosteric inhibitors targeting the SWII pocket (e.g., MRTX1133) show promise, limited chemical diversity and paradoxical cellular/enzymatic activity relationships necessitate the exploration of novel scaffolds. This study aims to develop KRAS-G12D inhibitors and PROTACs to offer a selection of new chemical entities through systematic structure–activity optimization and evaluate their therapeutic potential through PROTAC

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5

Bsat, Nada, and John D. Helmann. "Interaction of Bacillus subtilis Fur (Ferric Uptake Repressor) with the dhb Operator In Vitro and In Vivo." Journal of Bacteriology 181, no. 14 (1999): 4299–307. http://dx.doi.org/10.1128/jb.181.14.4299-4307.1999.

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ABSTRACT Bacillus subtilis contains three metalloregulatory proteins belonging to the ferric uptake repressor (Fur) family: Fur, Zur, and PerR. We have overproduced and purified Fur protein and analyzed its interaction with the operator region controlling the expression of the dihydroxybenzoate siderophore biosynthesis (dhb) operon. The purified protein binds with high affinity and selectivity to the dhb regulatory region. DNA binding does not require added iron, nor is binding reduced by dialysis of Fur against EDTA or treatment with Chelex. Fur selectively inhibits transcription from the dhb

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6

Wang, Xixi, Jiankai Shan, Wei Liu, et al. "Theoretical Studies on the Binding Mode and Reaction Mechanism of TLP Hydrolase kpHIUH." Molecules 26, no. 13 (2021): 3884. http://dx.doi.org/10.3390/molecules26133884.

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In this work, we have investigated the binding conformations of the substrate in the active site of 5-HIU hydrolase kpHIUH and its catalytic hydrolysis mechanism. Docking calculations revealed that the substrate adopts a conformation in the active site with its molecular plane laying parallel to the binding interface of the protein dimer of kpHIUH, in which His7 and His92 are located adjacent to the hydrolysis site C6 and have hydrogen bond interactions with the lytic water. Based on this binding conformation, density functional theory calculations indicated that the optimal catalytic mechanis

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7

Sanyanga, Taremekedzwa Allan, Bilal Nizami та Özlem Tastan Bishop. "Mechanism of Action of Non-Synonymous Single Nucleotide Variations Associated with α-Carbonic Anhydrase II Deficiency". Molecules 24, № 21 (2019): 3987. http://dx.doi.org/10.3390/molecules24213987.

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Human carbonic anhydrase II (CA-II) is a Zinc (Zn 2 + ) metalloenzyme responsible for maintenance of acid-base balance within the body through the reversible hydration of CO 2 to produce protons (H + ) and bicarbonate (BCT). Due to its importance, alterations to the amino acid sequence of the protein as a result of single nucleotide variations (nsSNVs) have detrimental effects on homeostasis. Six pathogenic CA-II nsSNVs, K18E, K18Q, H107Y, P236H, P236R and N252D were identified, and variant protein models calculated using homology modeling. The effect of each nsSNV was analyzed using motif ana

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8

Hempelmann, Franziska, Soraya Hölper, Mirka-Kristin Verhoefen, et al. "His75−Asp97 Cluster in Green Proteorhodopsin." Journal of the American Chemical Society 133, no. 12 (2011): 4645–54. http://dx.doi.org/10.1021/ja111116a.

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9

Tanley, Simon W. M., Antoine M. M. Schreurs, Loes M. J. Kroon-Batenburg, and John R. Helliwell. "Room-temperature X-ray diffraction studies of cisplatin and carboplatin binding to His15 of HEWL after prolonged chemical exposure." Acta Crystallographica Section F Structural Biology and Crystallization Communications 68, no. 11 (2012): 1300–1306. http://dx.doi.org/10.1107/s1744309112042005.

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The anticancer complexes cisplatin and carboplatin are known to bind to both the Nδand the N∊atoms of His15 of hen egg-white lysozyme (HEWL) in the presence of dimethyl sulfoxide (DMSO). However, neither binds in aqueous media after 4 d of crystallization and crystal growth, suggesting that DMSO facilitates cisplatin/carboplatin binding to the N atoms of His15 by an unknown mechanism. Crystals of HEWL cocrystallized with cisplatin in both aqueous and DMSO media, of HEWL cocrystallized with carboplatin in DMSO medium and of HEWL cocrystallized with cisplatin andN-acetylglucosamine (NAG) in DMSO

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10

Plowman, Jeffrey E., та Lawrence K. Creamer. "Restrained molecular dynamics study of the interaction between bovine κ-casein peptide 98–111 and bovine chymosin and porcine pepsin". Journal of Dairy Research 62, № 3 (1995): 451–67. http://dx.doi.org/10.1017/s0022029900031150.

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SummaryThe cleavage of bovine κ-casein at the Phe105–Met106* bond by chymosin or pepsin is the first stage in casein micelle coagulation and casein digestion. The nature of the interaction of the peptide His98–Pro–His–Pro–His–Leu–Ser–Phe105–Met–Ala–Ile–Pro-Pro-Lys111 with chymosin and porcine pepsin was investigated using molecular modelling and energy minimization techniques. This study verified and extended a proposed model that electrostatic binding (involving His98, His100, His102 and Lys111 or Lys112) at either end of the active site cleft of chymosin is important for the positioning of r

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11

Ni, Jie, Guochao Xu, Wei Dai, Yi-Lei Zhao, and Ye Ni. "Hyperconjugation promoted by hydrogen bonding between His98/His241 and a carboxyl group contributes to tyrosine decarboxylase catalysis." Catalysis Science & Technology 9, no. 22 (2019): 6222–26. http://dx.doi.org/10.1039/c9cy01290g.

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12

Ishikawa, Yasuko, Tomasz D. Pieczonka, Aneta M. Bragiel-Pieczonka, et al. "Long-Term Oral Administration of LLHK, LHK, and HK Alters Gene Expression Profile and Restores Age-Dependent Atrophy and Dysfunction of Rat Salivary Glands." Biomedicines 8, no. 2 (2020): 38. http://dx.doi.org/10.3390/biomedicines8020038.

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Xerostomia, also known as dry mouth, is caused by a reduction in salivary secretion and by changes in the composition of saliva associated with the malfunction of salivary glands. Xerostomia decreases quality of life. In the present study, we investigated the effects of peptides derived from β-lactoglobulin C on age-dependent atrophy, gene expression profiles, and the dysfunction of salivary glands. Long-term oral administration of Leu57-Leu58-His59-Lys60 (LLHK), Leu58-His59-Lys60 (LHK) and His59-Lys60 (HK) peptides induced salivary secretion and prevented and/or reversed the age-dependent atr

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13

de Cristóbal, Ricardo E., Jose O. Solbiati, Ana M. Zenoff, et al. "Microcin J25 Uptake: His5 of the MccJ25 Lariat Ring Is Involved in Interaction with the Inner Membrane MccJ25 Transporter Protein SbmA." Journal of Bacteriology 188, no. 9 (2006): 3324–28. http://dx.doi.org/10.1128/jb.188.9.3324-3328.2006.

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ABSTRACT Escherichia coli microcin J25 (MccJ25) is a plasmid-encoded antibiotic peptide consisting of 21 l-amino acid residues (G1-G-A-G-H5-V-P-E-Y-F10-V-G-I-G-T15-P-I-S-F-Y20-G). E. coli RNA polymerase (RNAP) is the intracellular target of MccJ25. MccJ25 enters cells after binding to specific membrane transporters: FhuA in the outer membrane and SbmA in the inner membrane. Here, we studied MccJ25 mutants carrying a substitution of His5 by Lys, Arg, or Ala. The inhibitory effects on cellular growth and in vitro RNAP activity were determined for each mutant microcin. The results show that all m

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14

HO, Heng-Chien, and Ta-Hsiu LIAO. "Protein structure and gene cloning of Syncephalastrum racemosum nuclease." Biochemical Journal 339, no. 2 (1999): 261–67. http://dx.doi.org/10.1042/bj3390261.

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The complete amino acid sequence of the fungus Syncephalastrum racemosum (Sr-) nuclease has been delineated on the basis of protein sequencing of the intact protein and its protease-digested peptides. The resulting 250-residue sequence shows a carbohydrate side chain attached at Asn134 and two half-cystine residues (Cys242 and Cys247) cross-linked to form a small disulphide loop. On the basis of the sequence of Sr-nuclease, a computer search in the sequence database yielded 60% and 48% positional identities with the sequences of Cunninghamella echinulata nuclease C1 and yeast mitochondria nucl

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15

Gras, Stephanie, Zhenjun Chen, John J. Miles, et al. "Allelic polymorphism in the T cell receptor and its impact on immune responses." Journal of Experimental Medicine 207, no. 7 (2010): 1555–67. http://dx.doi.org/10.1084/jem.20100603.

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In comparison to human leukocyte antigen (HLA) polymorphism, the impact of allelic sequence variation within T cell receptor (TCR) loci is much less understood. Particular TCR loci have been associated with autoimmunity, but the molecular basis for this phenomenon is undefined. We examined the T cell response to an HLA-B*3501–restricted epitope (HPVGEADYFEY) from Epstein-Barr virus (EBV), which is frequently dominated by a TRBV9*01+ public TCR (TK3). However, the common allelic variant TRBV9*02, which differs by a single amino acid near the CDR2β loop (Gln55→His55), was never used in this resp

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16

Pham, Vy H., Vu Q. Tran, and An Q. Pham. "Computational prediction of the potential L-type Lectin Receptor Kinases in Extracellular Adenosine Triphosphate binding." Research Journal of Biotechnology 20, no. 5 (2025): 175–81. https://doi.org/10.25303/205rjbt1750181.

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Plants can perceive extracellular adenosine triphosphate (eATP) as a signaling molecule via purinergic 2 kinase (P2K) receptors. However, (1) how eATP binds to these receptors is not well understood and (2) apart from AtP2K1 and AtP2K2, which have been experimentally confirmed in Arabidopsis thaliana, what other plant species besides Brassicaceae perceive eATP? Our report visualizes eATP in active binding sites of P2K1 and P2K2 compared with mutant p2k1His99Ala and p2k2His99Ala. Tomato, Solanum lycopersicum, was used to search for homologous eATP receptors outside Brassicaceae. Given that His9

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17

Ran, Tingting, Gabriel Ozorowski, Yanyan Gao, et al. "Cross-protomer interaction with the photoactive site in oligomeric proteorhodopsin complexes." Acta Crystallographica Section D Biological Crystallography 69, no. 10 (2013): 1965–80. http://dx.doi.org/10.1107/s0907444913017575.

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Proteorhodopsins (PRs), members of the microbial rhodopsin superfamily of seven-transmembrane-helix proteins that use retinal chromophores, comprise the largest subfamily of rhodopsins, yet very little structural information is available. PRs are ubiquitous throughout the biosphere and their genes have been sequenced in numerous species of bacteria. They have been shown to exhibit ion-pumping activity like their archaeal homolog bacteriorhodopsin (BR). Here, the first crystal structure of a proteorhodopsin, that of a blue-light-absorbing proteorhodopsin (BPR) isolated from the Mediterranean Se

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18

Tanley, Simon W. M., Antoine M. M. Schreurs, Loes M. J. Kroon-Batenburg, and John R. Helliwell. "Re-refinement of 4g4a: room-temperature X-ray diffraction study of cisplatin and its binding to His15 of HEWL after 14 months chemical exposure in the presence of DMSO." Acta Crystallographica Section F Structural Biology Communications 72, no. 3 (2016): 253–54. http://dx.doi.org/10.1107/s2053230x16000856.

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A re-refinement of 4g4a, the room-temperature X-ray diffraction study of cisplatin and its binding to His15 of HEWL after 14 months chemical exposure in the presence of DMSO is published as an addendum to Tanleyet al.[(2012),Acta Cryst.F68, 1300–1306]. This example illustrates the benefits of sharing raw diffraction images, as well as structure factors and molecular coordinates, as the diffraction resolution of the study is now much improved at 1.70 Å.

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19

Funhoff, Enrico G., Yunling Wang, Goran Andersson, and Bruce A. Averill. "Substrate positioning by His92 is important in catalysis by purple acid phosphatase." FEBS Journal 272, no. 12 (2005): 2968–77. http://dx.doi.org/10.1111/j.1742-4658.2005.04686.x.

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20

Yang, X., Y. Li, L. Huang, et al. "Diethylpyrocarbonate modification reveals HisB5 as an important modulator of insulin amyloid formation." Journal of Biochemistry 157, no. 1 (2014): 45–51. http://dx.doi.org/10.1093/jb/mvu052.

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21

Liu, Wen, Corina E. Rogge, Giordano F. Z. da Silva, et al. "His92 and His110 selectively affect different heme centers of adrenal cytochrome b561." Biochimica et Biophysica Acta (BBA) - Bioenergetics 1777, no. 9 (2008): 1218–28. http://dx.doi.org/10.1016/j.bbabio.2008.04.039.

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22

Ji, Keunho, Sondavid Nandanwar, So Yeon Jeon, et al. "Enhancing Paenibacillus sp. Cold-Active Acetyl Xylan Esterase Activity through Semi-Rational Protein Engineering." Applied Sciences 14, no. 13 (2024): 5546. http://dx.doi.org/10.3390/app14135546.

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Interest in protein engineering for the enzymatic production of valuable products, such as pharmaceutical compounds and biofuels, is growing rapidly. The cold-active acetyl xylan esterase from Paenibacillus sp. (PbAcE) presents unusually broad substrate specificity. Here, we engineered a hydrophobic substrate-binding pocket to enable the accommodation of relatively large alcohol substrates, such as linalyl acetate and α-terpinyl acetate. To identify candidate residues for engineering, we performed covalent docking of substrates to the Ser185 active site using the HCovDock program. Functional h

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23

Castro Torres, Mario Eduardo, Pablo Marcelo Vargas-Piérola, Carlos F. Pinto, and Rubén Alvarado. "Serial Mediation Model of Social Capital Effects over Academic Stress in University Students." European Journal of Investigation in Health, Psychology and Education 12, no. 11 (2022): 1644–56. http://dx.doi.org/10.3390/ejihpe12110115.

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Background: Although several studies have shown that social capital and social support decreases academic stress (AS), there has been lack of atheoretical model to explain how this occurs. This study aims to verify a model that explains the effect of bonding social capital (BSC) over academic stress psychological symptoms (PsyS), considering the multiple sequential mediation of socio-emotional support (SES), self-efficacy (sEffic) and self-esteem (sEstee). Methods: In a transversal study, 150 undergraduate volunteer students were recruited using non-probabilistic purposive sampling. Data were

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24

Zhang, Liang, Jacqueline Wax, Renliang Huang, Frank Petersen, and Xinhua Yu. "Meta-Analysis and Systematic Review of the Association between a Hypoactive NCF1 Variant and Various Autoimmune Diseases." Antioxidants 11, no. 8 (2022): 1589. http://dx.doi.org/10.3390/antiox11081589.

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Genetic association studies have discovered the GTF2I-NCF1 intergenic region as a strong susceptibility locus for multiple autoimmune disorders, with the missense mutation NCF1 rs201802880 as the causal polymorphism. In this work, we aimed to perform a comprehensive meta-analysis of the association of the GTF2I-NCF1 locus with various autoimmune diseases and to provide a systemic review on potential mechanisms underlying the effect of the causal NCF1 risk variants. The frequencies of the two most extensively investigated polymorphisms within the locus, GTF2I rs117026326 and NCF1 rs201802880, v

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25

Magrì, Antonio, Giovanni Tabbì, Irina Naletova, Francesco Attanasio, Giuseppe Arena, and Enrico Rizzarelli. "A Deeper Insight in Metal Binding to the hCtr1 N-terminus Fragment: Affinity, Speciation and Binding Mode of Binuclear Cu2+ and Mononuclear Ag+ Complex Species." International Journal of Molecular Sciences 23, no. 6 (2022): 2929. http://dx.doi.org/10.3390/ijms23062929.

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Ctr1 regulates copper uptake and its intracellular distribution. The first 14 amino acid sequence of the Ctr1 ectodomain Ctr1(1-14) encompasses the characteristic Amino Terminal Cu2+ and Ni2+ binding motif (ATCUN) as well as the bis-His binding motif (His5 and His6). We report a combined thermodynamic and spectroscopic (UV-vis, CD, EPR) study dealing with the formation of Cu2+ homobinuclear complexes with Ctr1(1-14), the percentage of which is not negligible even in the presence of a small Cu2+ excess and clearly prevails at a M/L ratio of 1.9. Ascorbate fails to reduce Cu2+ when bound to the

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26

King, Judy A., and Robert P. Millar. "Identification of His5, Trp7, Tyr8-GnRH (chicken GnRH II) in amphibian brain." Peptides 7, no. 5 (1986): 827–34. http://dx.doi.org/10.1016/0196-9781(86)90102-6.

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Bergo, Vladislav B., Joel M. Kralj, John L. Spudich, and Kenneth J. Rothschild. "His75 in Proteorhodopsin, a Novel Component in Light-Driven Proton Translocation by Primary Pumps." Biophysical Journal 96, no. 3 (2009): 526a. http://dx.doi.org/10.1016/j.bpj.2008.12.2713.

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28

Blank, J., T. Kupke, E. Lowe, P. Barth, R. B. Freedman, and L. W. Ruddock. "The Influence of His94 and Pro149 in Modulating the Activity of V. cholerae DsbA." Antioxidants & Redox Signaling 5, no. 4 (2003): 359–66. http://dx.doi.org/10.1089/152308603768295087.

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29

Qiu, Shenshen, Dongqing Xu, Mengxue Xu, et al. "Crystal structures of PigF, an O-methyltransferase involved in the prodigiosin synthetic pathway, reveal an induced-fit substrate-recognition mechanism." IUCrJ 9, no. 2 (2022): 316–27. http://dx.doi.org/10.1107/s2052252521011696.

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Prodigiosin, a red linear tripyrrole pigment, is a typical secondary metabolite with numerous biological functions, such as anticancer, antibacterial and immunosuppressant activities, and is synthesized through a bifurcated biosynthesis pathway from 4-methoxy-2,2′-bipyrrole-5-carbaldehyde (MBC) and 2-methyl-3-n-amylpyrrole (MAP). The last step in the biosynthetic pathway of MBC is catalysed by PigF, which transfers a methyl group to 4-hydroxy-2,20-bipyrrole-5-carbaldehyde (HBC) to form the final product MBC. However, the catalytic mechanism of PigF is still elusive. In this study, crystal stru

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30

Tanley, Simon W. M., and John R. Helliwell. "Chemical conversion of cisplatin and carboplatin with histidine in a model protein crystallized under sodium iodide conditions." Acta Crystallographica Section F Structural Biology Communications 70, no. 9 (2014): 1127–31. http://dx.doi.org/10.1107/s2053230x14013995.

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Cisplatin and carboplatin are platinum anticancer agents that are used to treat a variety of cancers. Previous X-ray crystallographic studies of carboplatin binding to histidine in hen egg-white lysozyme (HEWL) showed a partial chemical conversion of carboplatin to cisplatin owing to the high sodium chloride concentration used in the crystallization conditions. Also, the co-crystallization of HEWL with carboplatin in sodium bromide conditions resulted in the partial conversion of carboplatin to the transbromoplatin form, with a portion of the cyclobutanedicarboxylate (CBDC) moiety still presen

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31

Tsai, H., and L. A. Bobek. "Studies of the mechanism of human salivary histatin-5 candidacidal activity with histatin-5 variants and azole-sensitive and -resistant Candida species." Antimicrobial Agents and Chemotherapy 41, no. 10 (1997): 2224–28. http://dx.doi.org/10.1128/aac.41.10.2224.

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Histatins are a group of small, cationic, antifungal peptides present in human saliva. A previous molecular modeling analysis suggested structural similarity between the Phe14-His15 and His18-His19 dipeptide sequences in histatin-5 (Hsn-5; a 24-amino-acid polypeptide) and the sequence of miconazole (one of the azole-based antifungal therapeutic agents), implying that the mechanisms of killing of Candida albicans by these two molecules may be similar. To further elaborate on this observation, we have produced two variants of Hsn-5 in which Phe14-His15 or His18-His19 dipeptide sequences were rep

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KIMURA, Shigenobu, Akihiro KIKUCHI, Toshiya SENDA, Yoshitsugu SHIRO, and Masao FUKUDA. "Tolerance of the Rieske-type [2Fe-2S] cluster in recombinant ferredoxin BphA3 from Pseudomonas sp. KKS102 to histidine ligand mutations." Biochemical Journal 388, no. 3 (2005): 869–78. http://dx.doi.org/10.1042/bj20042077.

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BphA3 from Pseudomonas sp. KKS102 is a Rieske-type [2Fe-2S] ferredoxin that transfers electrons from an NADH-dependent oxidoreductase, BphA4, to a biphenyl dioxygenase complex. A high-level expression and purification system for the recombinant BphA3 in Escherichia coli was constructed. Two histidine ligands of the Rieske-type cluster in BphA3, were each replaced with serine, cysteine, asparagine and tyrosine. The single mutants, in which either His44 or His65 was replaced with a cysteine residue (CH and HC mutants respectively), and the double mutant, in which both histidine residues were rep

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Wang, Chunxue, Leslie L. Lovelace, Shengfang Sun, John H. Dawson, and Lukasz Lebioda. "Structures of K42N and K42Y sperm whale myoglobins point to an inhibitory role of distal water in peroxidase activity." Acta Crystallographica Section D Biological Crystallography 70, no. 11 (2014): 2833–39. http://dx.doi.org/10.1107/s1399004714017787.

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Sperm whale myoglobin (Mb) functions as an oxygen-storage protein, but in the ferric state it possesses a weak peroxidase activity which enables it to carry out H2O2-dependent dehalogenation reactions. Hemoglobin/dehaloperoxidase fromAmphitrite ornata(DHP) is a dual-function protein represented by two isoproteins DHP A and DHP B; its peroxidase activity is at least ten times stronger than that of Mb and plays a physiological role. The `DHP A-like' K42Y Mb mutant (K42Y) and the `DHP B-like' K42N mutant (K42N) were engineered in sperm whale Mb to mimic the extended heme environments of DHP A and

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34

Tito, Gabriella, Giarita Ferraro, and Antonello Merlino. "Dirhodium Tetraacetate Binding to Lysozyme at Body Temperature." International Journal of Molecular Sciences 26, no. 14 (2025): 6582. https://doi.org/10.3390/ijms26146582.

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Paddlewheel dirhodium complexes are cytotoxic compounds that are also used as catalysts and in the formation of Rh-based artificial metalloenzymes. Low-temperature structures of adducts formed by the model protein hen egg white lysozyme (HEWL) with dirhodium tetraacetate ([Rh2(μ-O2CCH3)4]) when crystals of the protein were treated with the metal compound at 20 °C demonstrated that [Rh2(μ-O2CCH3)4] in part breaks down upon reaction with HEWL; dimeric Rh-Rh units bind the side chains of Asp18 and the C-terminal carboxylate, and monometallic fragments coordinate the side chains of Arg14 and His15

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35

Grinthal, Alison, and Guido Guidotti. "Substitution of His59 Converts CD39 Apyrase into an ADPase in a Quaternary Structure Dependent Manner†." Biochemistry 39, no. 1 (2000): 9–16. http://dx.doi.org/10.1021/bi991751k.

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36

Dance, Ian. "New insights into the reaction capabilities of His195 adjacent to the active site of nitrogenase." Journal of Inorganic Biochemistry 169 (April 2017): 32–43. http://dx.doi.org/10.1016/j.jinorgbio.2017.01.005.

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37

Mirzabekov, Andrei D., Dmitrii V. Pruss, and Konstantin K. Ebralidse. "Chromatin superstructure-dependent crosslinking with DNA of the histone H5 residues Thr1, His25 and His62." Journal of Molecular Biology 211, no. 2 (1990): 479–91. http://dx.doi.org/10.1016/0022-2836(90)90366-t.

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38

Zeidler, Waltraud, Christian Egle, Sofia Ribeiro, et al. "Site-Directed Mutagenesis of Thermus thermophilus Elongation Factor Tu. Replacement of His85, Asp81 and Arg300." European Journal of Biochemistry 229, no. 3 (1995): 596–604. http://dx.doi.org/10.1111/j.1432-1033.1995.tb20503.x.

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39

Verhoef, Daniël, Mark Schreuder, Ka Lei Cheung, Pieter H. Reitsma, and Mettine H. A. Bos. "Engineered Factor Xa Variants Retain Procoagulant Activity Independent of Direct Factor Xa-Inhibitors." Blood 126, no. 23 (2015): 126. http://dx.doi.org/10.1182/blood.v126.23.126.126.

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Abstract The venom of the Australian Elapid snake Pseudonaja textilis contains a prothrombin-activating complex that consists of factor Xa (FXa) and factor Va (FVa) homologs which are evolutionary adapted to derail the hemostatic system of its prey, leading to runaway coagulation. These adaptations include functional resistance to inactivation by the main inhibitors of coagulation, antithrombin and activated protein C. Further studies revealed that venom FXa, unlike other FXa species, is also resistant to inhibition by direct oral FXa-inhibitors such as rivaroxaban and apixaban (Ki >1000 nM

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40

Tanley, Simon W. M., Laurina-Victoria Starkey, Lucinda Lamplough, Surasek Kaenket, and John R. Helliwell. "The binding of platinum hexahalides (Cl, Br and I) to hen egg-white lysozyme and the chemical transformation of the PtI6octahedral complex to a PtI3moiety bound to His15." Acta Crystallographica Section F Structural Biology Communications 70, no. 9 (2014): 1132–34. http://dx.doi.org/10.1107/s2053230x14014009.

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This study examines the binding and chemical stability of the platinum hexahalides K2PtCl6, K2PtBr6and K2PtI6when soaked into pre-grown hen egg-white lysozyme (HEWL) crystals as the protein host. Direct comparison of the iodo complex with the chloro and bromo complexes shows that the iodo complex is partly chemically transformed to a square-planar PtI3complex bound to the Nδatom of His15, a chemical behaviour that is not exhibited by the chloro or bromo complexes. Each complex does, however, bind to HEWL in its octahedral form either at one site (PtI6) or at two sites (PtBr6and PtCl6). As heav

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Py, Béatrice, Bortoli-German Isabelle, Jacques Haiech, Marc Chippaux, and Frédéric Barras. "Cellulase EGZ of Erwinia chrysanthemi: structural organization and importance of His98 and Glu133 residues for catalysis." "Protein Engineering, Design and Selection" 4, no. 3 (1991): 325–33. http://dx.doi.org/10.1093/protein/4.3.325.

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42

Tyukhtenko, Sergiy, Karrie Chan, Rubin Jiang, et al. "Hydrogen-Bonded His93 As a Sensitive Probe for Identifying Inhibitors of the Endocannabinoid Transport Protein FABP7." Chemical Biology & Drug Design 85, no. 5 (2014): 534–40. http://dx.doi.org/10.1111/cbdd.12440.

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43

Xue, Yafeng, Bengt-Harald Jonsson, Anders Liljas, and Sven Lindskog. "Modification of a metal ligand in carbonic anhydrase: Crystal structure of His94 →Glu human isozyme II." FEBS Letters 352, no. 2 (1994): 137–40. http://dx.doi.org/10.1016/0014-5793(94)00936-8.

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44

Mashima, Tsuyoshi, Koji Oohora, and Takashi Hayashi. "Substitution of an amino acid residue axially coordinating to the heme molecule in hexameric tyrosine-coordinated hemoprotein to enhance peroxidase activity." Journal of Porphyrins and Phthalocyanines 21, no. 12 (2017): 824–31. http://dx.doi.org/10.1142/s1088424617500936.

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To convert an originally tyrosine-coordinated heme to histidine-coordinated heme in hexameric tyrosine-coordinated hemoprotein, HTHP, Tyr45, a residue coordinating to the heme cofactor, and Arg25 located in the distal site are replaced with Phe45 and His25, respectively in each of the subunits of the protein. The obtained HTHP mutant (HTHP[Formula: see text] was characterized by SDS-PAGE, ESI-TOF MS, dynamic light scattering measurements and size exclusion chromatography. These analyses indicate that HTHP[Formula: see text] maintains its stable hexameric structure with the altered ligation of

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Plamondon, Pascale, Denis Brochu, Suzanne Thomas, et al. "Phenotypic Consequences Resulting from a Methionine-to-Valine Substitution at Position 48 in the HPr Protein of Streptococcus salivarius." Journal of Bacteriology 181, no. 22 (1999): 6914–21. http://dx.doi.org/10.1128/jb.181.22.6914-6921.1999.

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ABSTRACT In gram-positive bacteria, the HPr protein of the phosphoenolpyruvate:sugar phosphotransferase system (PTS) can be phosphorylated on a histidine residue at position 15 (His15) by enzyme I (EI) of the PTS and on a serine residue at position 46 (Ser46) by an ATP-dependent protein kinase (His∼P and Ser-P, respectively). We have isolated fromStreptococcus salivarius ATCC 25975, by independent selection from separate cultures, two spontaneous mutants (Ga3.78 and Ga3.14) that possess a missense mutation in ptsH (the gene encoding HPr) replacing the methionine at position 48 by a valine. The

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Lin, Ying-Ju, and Suh-Chin Wu. "Histidine at Residue 99 and the Transmembrane Region of the Precursor Membrane prM Protein Are Important for the prM-E Heterodimeric Complex Formation of Japanese Encephalitis Virus." Journal of Virology 79, no. 13 (2005): 8535–44. http://dx.doi.org/10.1128/jvi.79.13.8535-8544.2005.

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ABSTRACT The formation of the flavivirus prM-E complex is an important step for the biogenesis of immature virions, which is followed by a subsequent cleavage of prM to M protein through cellular protease to result in the production and release of mature virions. In this study, the intracellular formation of the prM-E complex of Japanese encephalitis virus was investigated by baculovirus coexpression of prM and E in trans in Sf9 insect cells as analyzed by anti-E antibody immunoprecipitation and sucrose gradient sedimentation analysis. A series of carboxyl-terminally truncated prM mutant bacul

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Budanov, Andrei V., Tzipora Shoshani, Alexander Faerman, et al. "Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability." Oncogene 21, no. 39 (2002): 6017–31. http://dx.doi.org/10.1038/sj.onc.1205877.

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48

Sakurada, Tkukasa, Akinori Sugiyama, Koichi Tanno, Shinobu Sakurada, Masataka Ohba, and Kensuke Kisara. "Pharmacological profile of tachykinin NK1 receptor antagonist, [Tyr6, D-Trp7, D-His9] substance P." Japanese Journal of Pharmacology 67 (1995): 81. http://dx.doi.org/10.1016/s0021-5198(19)46292-6.

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Nishiwaki, Kiyoji, Naoyuki Hayashi, Shinji Irie, Dong-Hyo Chung, Satoshi Harashima, and Yasuji Oshima. "Structure of the yeast HIS5 gene responsive to general control of amino acid biosynthesis." Molecular and General Genetics MGG 208, no. 1-2 (1987): 159–67. http://dx.doi.org/10.1007/bf00330437.

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50

PLOWMAN, JEFFREY E., LAWRENCE K. CREAMER, MICHAEL J. LIDDELL та JENNIFER J. CROSS. "Structural features of a peptide corresponding to human κ-casein residues 84–101 by 1H-nuclear magnetic resonance spectroscopy". Journal of Dairy Research 66, № 1 (1999): 53–63. http://dx.doi.org/10.1017/s0022029998003318.

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The peptide Val–Arg–Arg–Pro–Asn–Leu–His–Pro–Ser–Phe–Ile–Ala–Ile–Pro–Pro–Lys–Lys–Ile, which corresponds to residues 84–101 of human κ-casein, has been synthesized and its conformation preferences determined by 1H-nuclear magnetic resonance spectroscopy in dimethyl sulphoxide. The peptide adopted a largely extended chain conformation in solution and there was evidence for the presence of a β-turn involving residues Pro87–His90 of human κ-casein. The presence of a turn in this position would make the physiologically significant Arg85 residue of human κ-casein (which is equivalent to Arg97 in bovi

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