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Journal articles on the topic 'Histamine_ mediated symptoms and topical corticosteroids'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Muralinath, E., Kumar A. Tanuz, Kumar S. Mumtesh, et al. "Exploring the Role of Antihistamines in Dermatology: A Comprehensive Overview." Research and Reviews: Journal of Dermatology Nursing 1, no. 1 (2024): 1–6. https://doi.org/10.5281/zenodo.10554243.

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<em>Anti-histamines, originally developed to alleviate symptoms of allergies, play an important role in the field of dermatology. These drugs, which primarily target histamine receptors, participate on in a multifaceted role in managing different types of skin conditions. Histamine plays an important role in allergic reactions and inflammatory responses. In dermatology, conditions namely allergic contact dermatitis, pruritus and urticaria are manifested by an overactive histaminergic response. Anti-histamine performs by blocking histamine receptors, thereby mitigating symptoms associated with

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Hartanto, Firstine Kelsi, Jeff Jeff Tjokro, Vivi Angelina, and Maria Leny Raiyon. "SIBLINGS WITH ALLERGIC ANGIOEDEMA: A CASE SERIES ON ORAL ALLERGIC SYNDROME AND FAMILIAL ATOPY." Dentino: Jurnal Kedokteran Gigi 10, no. 1 (2025): 100. https://doi.org/10.20527/dentino.v10i1.22212.

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Background: Oral Allergy Syndrome (OAS) is a localized IgE-mediated food allergy triggered by certain fruits and vegetables in patients with atopic history. This case report describes two siblings with Oral Allergy Syndrome (OAS) presenting as allergic angioedema triggered by specific food allergens. Case Presentation: Case 1 involves a 25-year-old female who developed lip swelling, a burning sensation, numbness, multiple oral ulcers on the lower lip, and surrounding redness 30 minutes after consuming mint sauce in an Indian dish. Case 2 details a 21-year-old male who experienced immediate lip

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Starostina, Svetlana V., and Alexey V. Toldanov. "Intranasal corticosteroid use in patients with allergic rhinitis." Consilium Medicum 23, no. 12 (2021): 950–55. http://dx.doi.org/10.26442/20751753.2021.12.201301.

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Allergic rhinitis (AR) is one of the most common diseases in the world, which is based on IgE-mediated inflammation that develops after exposure to various allergens. About 40% of people suffer from the same or other allergic diseases, every third inhabitant of the Earth has symptoms of AR and every tenth has bronchial asthma. According to the ARIA classification, ARs are divided: by the nature of the flow, by the severity of the flow and by the stage of the flow; for symptoms, the proposed therapy, consisting of sequential steps. Groups of drugs include: systemic or topical blockers of histam

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Elsayed, Eiman Hamza Ahmed, and Rabab Elsayed Ali Hassan Khater. "Revolutionizing Pediatric Dermatology: Dupilumab’s Impact on Atopic Dermatitis in Kids." American Journal of Life Science and Innovation 3, no. 1 (2024): 61–68. http://dx.doi.org/10.54536/ajlsi.v3i1.2696.

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Eczema, or atopic dermatitis, is a common, non-communicable, immune-mediated, inflammatory skin illness mainly affecting children. It is a chronic condition. It causes mental health problems like anxiety, sadness, anxiety, depression, hyperactivity, and obesity. It is the first skin ailment and the fifteenth non-fatal disease. The purpose of the present research study was to evaluate the Safety and Effectiveness of biological treatment for atopic dermatitis using monoclonal antibodies against non-biological treatment, including antibiotics, immunosuppressants, demards, histamine antagonists an

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Sakshi, Sharma* Anchal Sankhyan Dr. Dev Prakash Dahiya Shelly Indu. "A Review of Eczema: Current Therapies and Emerging Treatments." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2718–26. https://doi.org/10.5281/zenodo.15440679.

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Atopic dermatitis, commonly known as eczema, is a chronic relapsing skin disease characterized by pruritus, disruption of the epidermal barrier function, and immunoglobulin E-mediated sensitization to food and environmental allergens, which can lead to morbidity. Eczema is not always easy to control and every physician should know the essential principles of treatment. Symptoms, such as inflamed papules, plaques, and itching, and associated consequences, such as sleep disturbances, can have a significant impact on the quality of life of the patient and his family. Basic pharmacological treatme

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Raj, Vishwanath Prem, Nitin Pandit Tayade, Chandrashekhar V. Kiswe, et al. "Topical therapy with clobetasol propionate 0.025% for various dermatological conditions." International Journal of Research in Medical Sciences 10, no. 2 (2022): 512. http://dx.doi.org/10.18203/2320-6012.ijrms20220301.

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Topical corticosteroids (TC) are the most commonly prescribed medications for the treatment of several dermatoses. Owing to their potent effect of relieving symptoms, these drugs are indicated for the use of inflammatory and pruritic presentations of dermatologic conditions. Clobetasol propionate (CP) is the most common TC used to treat itching, redness, and swelling caused by some skin conditions. It possesses anti-inflammatory, antipruritic, and vasoconstrictive properties. To exert its effect, CP binds to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid recepto

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Choi, Hyun Ho. "Eosinophilic Esophagitis: Emerging Insights Into Diagnosis and Management." Korean Journal of Helicobacter and Upper Gastrointestinal Research 25, no. 2 (2025): 117–25. https://doi.org/10.7704/kjhugr.2025.0013.

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Eosinophilic esophagitis (EoE) is a chronic, immune-mediated, esophageal disease characterized by eosinophilic infiltration and symptoms such as dysphagia, food impaction, and esophageal dysfunction. Advances in diagnostic tools, including the EoE Endoscopic Reference Score and the Eosinophilic Esophagitis Histologic Scoring System, have improved disease characterization and monitoring. First-line treatments, such as proton pump inhibitors and topical corticosteroids, achieve significant histological and clinical remission rates. Dietary approaches, including the six-food elimination diet and

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Yashdeep, Singh. "Dermatology OPD Patients' Misuse of Topical Steroid." International Journal of Toxicological and Pharmacological Research 13, no. 1 (2023): 316–19. https://doi.org/10.5281/zenodo.11410687.

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<strong>Background: </strong>Today, topical corticosteroids are the most often prescribed medications in dermatology offices. The therapeutic effects are mediated by their anti-inflammatory, vasoconstrictive, anti-proliferative, and immunosuppressive properties. They are powerful drugs used to manage a range of inflammatory and autoimmune dermatological conditions. According to information on acknowledged dermatological indications of TC provided on the Central Drugs Standard Control Organization (CDSCO) website (although indications are not specified for all the TC molecules), off-label

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Armario-Hita, JC, M. Galán-Gutiérrez, JM Dodero-Anillo, JM Carrascosa, and R. Ruiz-Villaverde. "Updated Review on Treatment of Atopic Dermatitis." Journal of Investigational Allergy and Clinical Immunology 33, no. 3 (2023): 158–67. http://dx.doi.org/10.18176/jiaci.0906.

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Atopic dermatitis (AD) is a chronic or chronically recurrent Inflammatory dermatosis associated with multiple triggers that has a complex pathophysiological mechanism. It is characterized by a heterogeneous clinical expression, signs, and symptoms. Its etiology and pathogenesis are complex and are influenced by multiple immune-mediated factors. Treatment of AD can also be complex, given the high number of available drugs and multiple therapeutic targets. In this review, we summarize current literature on the efficacy and safety of topical and systemic drugs to treat moderate-to-severe AD. We b

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Soares, Alexa, and Olayemi Sokumbi. "Recent Updates in the Treatment of Erythema Multiforme." Medicina 57, no. 9 (2021): 921. http://dx.doi.org/10.3390/medicina57090921.

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Erythema multiforme (EM) is an immune-mediated condition that classically presents with discrete targetoid lesions and can involve both mucosal and cutaneous sites. While EM is typically preceded by viral infections, most notably herpes simplex virus (HSV), and certain medications, a large portion of cases are due to an unidentifiable cause. EM can be confused with other more serious conditions like Stevens–Johnson syndrome (SJS); however, clinical research has provided significant evidence to classify EM and SJS as separate disorders. Treatment of EM is highly variable, depending on the etiol

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Forouzanpour, Diba, Golara Ostovari, Mehrdad Mashhadi, Hossein Dehghani, and Ali Hajimohammadi. "Habronemiasis (Equine Summer Sore) in an 8-year-old Arab Horse." Farm Animal Health and Nutrition 1, no. 2 (2022): 46–49. http://dx.doi.org/10.58803/fahn.v1i2.12.

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Introduction: Habronemiasis, equine summer sore, is caused by habronema larvae, commonly in tropical and subtropical climates. House flies, face flies, and stable flies transmit the pathogenic nematode larvae. Cutaneous habronemiais is the most common form of habronemiasis in horses. Cutaneous habronemiais is associated with the deposition of larvae in areas where they cannot complete their life cycle. Deposition of larvae is related to local hypersensitivity. Habronema larvae could cause preocular infectious resulting in conjunctivitis, blepharitis, or dermatitis. Case report: An eight-year-o

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Sruthi Ramanan, Bipneet Singh, Thai Hau Koo, et al. "Meta-analysis of the role of steroids in Eosinophilic esophagitis." International Journal of Science and Research Archive 14, no. 3 (2025): 141–47. https://doi.org/10.30574/ijsra.2025.14.3.0616.

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Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory disease of the esophagus that manifests as eosinophil-predominant infiltration. Swallowed topical steroids have been the preferred medications for EoE as they relieve symptoms and restore the pathology. This meta-analysis comprehensively examined whether steroid application is the best therapy for histologic, cell morphologic, and endoscopic findings compared to placebo in eosinophilic esophagitis. A literature search was conducted on various medical databases to identify relevant randomized controlled trials (RCTs) that

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Wąsik, Jakub, and Ewa Małecka-Wojciesko. "Eosinophilic Esophagitis—What Do We Know So Far?" Journal of Clinical Medicine 12, no. 6 (2023): 2259. http://dx.doi.org/10.3390/jcm12062259.

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Eosinophilic esophagitis is a Th-2 antigen-mediated disease in which there is an influx of eosinophils to all layers of the esophagus, triggering an inflammatory response. Chronic inflammatory process causes esophageal remodeling, leading to difficulties in swallowing. Food impaction, heartburn, and chest pain are other characteristic (but not pathognomonic) symptoms in adults. Although the disease has only been described since in the early 1970s, its incidence and prevalence are rapidly growing, especially in Western countries. According to the diagnostic guidelines, there should be at least

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Paganelli, Alessia, Luca Contu, Elena Ficarelli, Federico Garbarino, and Alberico Motolese. "Management of Lichen Sclerosus and Related Comorbidities at a Tertiary Referral Center: Beyond Topical Steroids." Dermatology Practical & Conceptual 14, no. 4 (2024): e2024262. http://dx.doi.org/10.5826/dpc.1404a262.

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Introduction: Lichen sclerosus (LS) is a chronic inflammatory dermatosis predominantly affecting the anogenital area, with potential systemic implications. Objective: Our aim is to elucidate its clinical characteristics and management strategies. Methods: We conducted a retrospective observational study on adult patients with LS referred to our center between January 2022 and December 2023. Results: Forty-six adult subjects affected by LS were enrolled in the present study. The majority of patients presented with genital involvement, but a significant subset exhibited extragenital LS and conco

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Gasruthi, Margana, and SripathiSonika Shruti. "Phenytoin Induced Exfoliative Dermatitis: Adverse Drug Reaction (Adr): Case Report." International Journal of Pharmaceutical Research and Applications 09, no. 06 (2024): 804–6. https://doi.org/10.35629/4494-0906804806.

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Phenytoin-induced exfoliative dermatitis, a severe adverse reaction to the antiepileptic medication phenytoin, poses significant clinical challenges. This rare but serious condition, encompassing Stevens - Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in its severe forms, is characterized by widespread skin inflammation, blistering, and epidermal detachment. The exact mechanisms triggering phenytoin-induced exfoliative dermatitis involve a complex interplay of immune-mediated responses and genetic predispositions. Phenytoin can induce a hypersensitivity reaction, leading to the r

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Araujo-Silva, Gabriel, Gabriel de Toledo Telles-Araújo, and Liliane Lins-Kusterer. "Therapeutic Test for Differential Diagnosis of Erosive oral Lichen Planus: a Case Report." ARCHIVES OF HEALTH INVESTIGATION 13, no. 7 (2024): 2351–54. http://dx.doi.org/10.21270/archi.v13i7.6397.

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Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease, mediated by T cells, whose etiology remains unknown. Clinically, OLP can also be classified into reticular, papular, atrophic, and erosive, being erosive oral lichen planus (EOLP) the second most common. The objective of this study is to report a case of EOLP submitted to a therapeutic test. A 51-year-old female patient presented with a crusted ulcerative lesion on the lower lip, bleeding to the touch, and painful symptoms, within a five-year evolution. Extraoral examination revealed an ulcerated lesion on the lower lip,

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Surdea-Blaga, Teodora, Elvis Popovici, Mihaela Fadgyas Stănculete, Dan Lucian Dumitrascu, and Carmelo Scarpignato. "Eosinophilic Esophagitis: Diagnosis and Current Management." Journal of Gastrointestinal and Liver Diseases 29, no. 1 (2020): 85–97. http://dx.doi.org/10.15403/jgld-768.

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Eosinophilic esophagitis (EoE) is an eosinophil-rich, Th2 antigen-mediated disease of increasing worldwideprevalence. Originally considered common in children and young adults, it can be seen at any age, withthe highest prevalence between 30 and 40 years. Symptoms reflect esophageal dysfunction, and typicalendoscopic pictures consist of rings, furrows, exudates and edema. Progressive disease leads to pathologictissue remodeling, with ensuing esophageal rigidity and loss of luminal diameter caused by strictures. Thedefinitive diagnosis is histological (at least 15 eosinophils/HPF, high power fi

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Rutwa, Rabadiya Rutwa Rabadiya, Neha Kevat Neha Kevat, Patel Sneha Patel Sneha, Rohit Pratham, and Khushboo katharotiya Dr. "Psoriasis : A Comprehensive Review of Current and Emerging Therapies." International Journal for Research Trends and Innovation 10, no. 1 (2025): a90—a107. https://doi.org/10.5281/zenodo.14629519.

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The inflammatory skin condition known as psoriasis is a chronic immune-mediated condition marked by keratinocyte hyperproliferation and a number of systemic comorbidities. With an emphasis on recent developments in our knowledge of the functions of particular immune cells and cytokines in the onset and maintenance of disease, we examine the intricate interactions between genetic, environmental, and immunological factors that contribute to its pathogenesis. There is a thorough discussion of the clinical signs and symptoms of psoriasis, which include guttate, inverted, p

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Kalandra, Kara Citra, and Rifna Lutfiamida. "NON-NECROTIZING DIFFUSE ANTERIOR SCLERITIS AS AN ISOLATED OCULAR MANIFESTATION OF SYSTEMIC LUPUS ERYTHEMATOSUS: A CASE REPORT." Ophthalmologica Indonesiana 49, no. 2 (2023): 197–202. http://dx.doi.org/10.35749/journal.v49i2.100763.

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Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disorder with heterogeneous clinical manifestation in numerous organ systems, including the eye. Ocular involvements have been reported in up to one-third of patients with SLE, although scleritis is considered a less common manifestation of the disease found in only about 1% of cases Case Report: A 46-year-old female patient presented with a painful right eye for 1 week. She reported having the same symptom last year which resolved without treatment. There was no known history of systemic immune-mediated diseases and no prior oc

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Alghamdi, Fadi A., Shahad T. Khayyat, Mohammed M. Alshareef, and Wala’a Felemban. "New-Onset Lichen Planus Induced by the Pfizer COVID-19 Vaccine." Case Reports in Dermatological Medicine 2022 (September 17, 2022): 1–4. http://dx.doi.org/10.1155/2022/2082445.

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Objective. Coronavirus disease 2019 (COVID-19) vaccine distribution continues to expand; however, increased cutaneous reactions have been reported. Several recent studies suggest a link between COVID-19 vaccination and the development of various cutaneous complications. Lichen planus is a chronic, immune-mediated, inflammatory dermatological illness with an unclear etiology. In this case report, we assessed the relationship between COVID-19 vaccination (Pfizer) and lichen planus diagnosis and evaluated the link between additional doses of the vaccine and disease progression. Methods. Complete

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Pastuszka, Artur, Karolina Serwońska, Aleksandra Galanty-Ochyra, et al. "Atopic condition of the esophagus - eosinophilic esophagitis - literature review." Journal of Education, Health and Sport 80 (April 26, 2025): 59373. https://doi.org/10.12775/jehs.2025.80.59373.

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Introduction and purpose Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disorder causing esophageal dysfunction in children and adults. Characterized by eosinophilic inflammation, EoE leads to dysphagia, food impaction, and esophageal remodeling. Since its classification in the 1990s, research has expanded, yet aspects of its pathogenesis, diagnosis, and management remain under investigation. This review compiles current knowledge on EoE, covering its pathophysiology, epidemiology, clinical presentation, diagnosis, treatment, and prognosis. By integrating recent findings and guid

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Syabbalo, Nightingale. "The role of biologics in the pathogenesis and treatment of eosinophilic esophagitis." Gastroenterology & Hepatology: Open Access 14, no. 1 (2023): 27–29. http://dx.doi.org/10.15406/ghoa.2023.14.00539.

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Eosinophilic esophagitis (EoE) is a chronic immune-mediated disorder characterized by inflammation, and intraepithelial infiltration of eosinophils in the esophageal epithelium. It is associated with unbearable symptoms, such as dysphagia, and bolus impaction which affect the nutritional status, and quality of life of the patients. It is diagnosed from a thorough medical history, and confirmed by endoscopy and esophageal biopsy. Traditionally, it has been treated with elimination diet, proton pump inhibitors, and swallowed topical corticosteroids. However, several of the patients with EoE are

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Surjani, Lylys. "PENANGANAN KOMPREHENSIF PADA VERNAL CONJUNGTIVITIS." Majalah Ilmiah METHODA 10, no. 1 (2020): 47–52. http://dx.doi.org/10.46880/methoda.vol10no1.pp47-52.

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Vernal keratoconjunctivitis (VKC) is an allergic eye disease with a chronic inflammatory condition, mostly bilateral, and affects upper tarsal conjunctiva. VKC is characterized by conjunctival infiltration by various types of inflammatory cells, especially eosinophils, although VKC was previously considered an IgE-mediated disease, but several other immunological pathways such as an increase of activated CD4 + T-lymphocytes, especially Th2, indicates that hypersensitivity reactions are found against unknown pathogens. The rate of eye infection with shield ulcers ranges from about 9-10% which S

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Surjani, Lylys. "PENANGANAN KOMPREHENSIF PADA VERNAL CONJUNGTIVITIS." Majalah Ilmiah METHODA 10, no. 1 (2020): 47–52. http://dx.doi.org/10.46880/methoda.v10i1.546.

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Vernal keratoconjunctivitis (VKC) is an allergic eye disease with a chronic inflammatory condition, mostly bilateral, and affects upper tarsal conjunctiva. VKC is characterized by conjunctival infiltration by various types of inflammatory cells, especially eosinophils, although VKC was previously considered an IgE-mediated disease, but several other immunological pathways such as an increase of activated CD4 + T-lymphocytes, especially Th2, which indicates that hypersensitivity reactions are found against unknown pathogens. The rate of eye infection with shield ulcers ranges from about 9-10% w

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Vracaric, Vladimir, Zeljka Savic, Mirjana Zivojinov, Dragomir Damjanov, Zarko Krnetic, and Tatiana Jocic. "An enigma of eosinophilic esophagitis." Vojnosanitetski pregled 74, no. 1 (2017): 64–68. http://dx.doi.org/10.2298/vsp150723148v.

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Introduction. Eosinophilic esophagitis is a chronic immunogenic-antigen mediated disease of the esophagus, characterized by symptoms related to esophagus dysfunction, histologically defined by over 15 eosinophil counts seen in high-power microscopic field, without gastroesophageal reflux disease. In adults, the most common clinical manifestations are dysphagia, reflux, chest pain, regurgitation and bolus impaction. Case report. We presented the case of a female patient, hospitalized for a serious form of pancreatitis with complications, which required artificial ventilation and enteral feeding

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Farah, Amir, Tarek Assaf, Jawad Hindy, et al. "The Dynamic Evolution of Eosinophilic Esophagitis." Diagnostics 15, no. 3 (2025): 240. https://doi.org/10.3390/diagnostics15030240.

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Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory condition of the esophagus characterized by eosinophilic infiltration, and hallmark symptoms of esophageal dysfunction such as dysphagia and food impaction. Over the past three decades, EoE has been recognized as a distinct clinical entity, distinguished from gastroesophageal reflux disease (GERD) through advancements in diagnostic techniques, particularly endoscopy with biopsy. The rising global prevalence of EoE reflects enhanced diagnostic awareness, evolving criteria, and environmental along with lifestyle changes. T

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Kaibysheva, V. O., S. V. Shchelochenkov, T. D. Shchelochenkova, et al. "Eosinophilic gastritis, enteritis, and colitis: understudied subtypes within the spectrum of eosinophilic gastrointestinal disorders. A literature review." Russian Journal of Evidence-Based Gastroenterology 14, no. 2 (2025): 50. https://doi.org/10.17116/dokgastro20251402150.

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Objective. In recent years, several key consensus documents have been published on eosinophilic gastrointestinal disorders (EGIDs). This review aims to analyze the literature and discuss core concepts, including terminology and classification, etiology, pathogenesis, and treatment of eosinophilic gastritis, enteritis, and colitis. Key points. Eosinophilic gastrointestinal disorders are a group of immune-mediated diseases of unknown etiology, characterized by eosinophilic infiltration of the walls of hollow gastrointestinal organs—from the mucosa to the serosa—resulting in significant clinical

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Swati, Prasad, Chandra Shradha, and Babu Helena. "Bilastine with Montelukast and Fexofenadine with Montelukast in Allergic Rhinitis: A Randomized Control Trial." International Journal of Pharmaceutical and Clinical Research 16, no. 6 (2024): 2282–89. https://doi.org/10.5281/zenodo.13120255.

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<strong>Introduction:</strong> Allergic rhinitis is a global disease. It is an inflammatory disease affecting the mucosa of nasal cavity caused by exposure to an allergen which triggers IgE- mediated inflammation. There are four major symptoms of Allergic Rhinitis which includes – sneezing, rhinorrhea, nasal itching, and nasal congestion. The mainstay of management of allergic rhinitis is avoidance of allergens. Other treatments include intranasal corticosteroids, short term nasal decongestants, oral or topical H1 receptor antagonists (antihistamines), anticholinergic agents, intran

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Afri Ahya Suardi, Deis Hikmawati, and Rafdi Ahmed. "Karakteristik Pasien Dermatitis Kontak Alergi di RSAl Bandung (2019–2023)." Bandung Conference Series: Medical Science 5, no. 1 (2025): 1177–84. https://doi.org/10.29313/bcsms.v5i1.17612.

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Abstract. Allergic contact dermatitis (ACD) is a skin condition mediated by an immunological reaction caused by skin contact with allergens previously encountered. This study aims to describe the prevalence and characteristics of ACD patients at the Skin and Venereology Polyclinic of RSAI Bandung during the period of 2019–2023. The study used a descriptive retrospective cross-sectional method, collecting data from 58 medical records of patients who met the inclusion criteria using a total sampling approach, where data were collected without calculating a minimum sample size. The data collected

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Masic, N., S. I. Anjie, R. Sungur, et al. "P1120 New-onset Inflammatory Bowel Disease is uncommon in patients with psoriasis, psoriatic arthritis and spondylarthritis treated with secukinumab: a retrospective cohort study in a tertiary centre." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i2010—i2011. http://dx.doi.org/10.1093/ecco-jcc/jjad212.1250.

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Abstract Background Secukinumab (SEC) is an IL-17A inhibitor prescribed in patients with immune mediated inflammatory diseases like psoriasis (PsO), psoriatic arthritis (PsA) and spondylarthritis (SpA). Conflicting data are available on the onset of inflammatory bowel disease (IBD) among patients after the start of SEC. We aimed to provide data evaluating pre-existing and newly diagnosed IBD in patients being treated with SEC. Methods All patients receiving SEC at a single tertiary centre in The Netherlands between 2012-2022 were identified through the pharmacy registry. Data from electronic m

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Ringer, A., A. M. Smichowski, R. Gomez, et al. "POS1334 OCULAR CICATRICIAL PEMPHIGOID: IS THERE AN ASSOCIATION WITH AUTOIMMUNE DISEASES?" Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1005.1–1005. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1425.

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BackgroundOcular Cicatricial Pemphigoid (OCP) is an infrequent, systemic cicatricial immune-mediated disease, belonging to the group of membranous-mucosal pemphigoids (MMP). Due to the possibility of coexistence of multiple autoimmune diseases (ADs), OCP could be associated with other diseases. In the literature, association of OCP and ADs is reported in 9-35% of patients, but most reports correspond to MMP.ObjectivesTo assess the prevalence of autoimmune diseases associated with OCP and to analyse clinical, laboratorial and treatment associations between these entities.MethodsA multicentre cr

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Samantha, Boever Andrew Chang Kylie Daguio James Keane and Leonard B. Goldstein*. "Low-Dose Radiation Therapy for Painful Osteoarthritis: An Emerging Treatment Modality." World Journal of Health and Medicine 1, no. 3 (2024): 80–86. https://doi.org/10.5281/zenodo.10611600.

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<strong>Abstract</strong> Osteoarthritis is the most common degenerative joint disease worldwide, and its prevalence is steadily rising due to an aging population and increased risk factors such as obesity and sedentary lifestyles. Despite the increase in investigative research on Low-Dose Radiation Therapy (LDRT) occurring in other countries and current clinical use, LDRT is inappreciably used in the United States. Numerous studies published outside the U.S. indicate moderate to long-term pain relief and increased mobility following the treatment of joints affected by osteoarthritis with LDRT

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Shetty, Kshitya, and Atul P. Sherje. "Nano intervention in topical delivery of corticosteroid for psoriasis and atopic dermatitis—a systematic review." Journal of Materials Science: Materials in Medicine 32, no. 8 (2021). http://dx.doi.org/10.1007/s10856-021-06558-y.

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AbstractAtopic dermatitis (AD) and psoriasis are highly prevalent, complex, chronic inflammatory skin diseases that immensly affect the patient’s quality of life. While there is no definitive cure for these conditions, suppressive medications aim at managing the symptoms of these diseases. The application of emollients accompanied by symptomatic anti-inflammatory therapy consisting of topical corticosteroids (TCS) is extensively employed for controlling the symptoms among general practitioners making this therapeutic class an indispensable pillar of dermatotherapeutics. The first TCS, hydrocor

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Alsohaibani, Fahad I., Musthafa C. Peedikayil, Mohammed A. Alzahrani, et al. "Eosinophilic esophagitis: Current concepts in diagnosis and management." Saudi Journal of Gastroenterology, May 16, 2024. http://dx.doi.org/10.4103/sjg.sjg_50_24.

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Abstract Eosinophilic esophagitis is an antigen-mediated chronic inflammatory disorder that has risen in incidence and prevalence over the past 2 decades. The clinical presentation is variable and consists of mainly esophageal symptoms such as dysphagia, heartburn, food impaction, and vomiting. Current management relies on dietary elimination, proton-pump inhibitors, and topical corticosteroids with different response rates and relapses after treatment discontinuation. With a better understanding of the underlying pathophysiology, many molecules emerged recently as targeted treatment including

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"Mechanistic Action, Clinical Efficacy, and Comparative Effectiveness of Ozone Therapy Versus Standard Treatments in Psoriasis: A Review." Studies in Multidisciplinary Medical Research, January 4, 2025, 40–49. https://doi.org/10.32592/smmr.202501.04.06.

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Psoriasis, a chronic immune-mediated inflammatory skin disease, is driven by keratinocyte hyperproliferation and dysregulated cytokine activity (e.g., TNF-α, IL-17, IL-23), significantly impacting quality of life. Standard treatments, including topical corticosteroids, phototherapy, and biologics, are effective but often limited by relapses, adverse effects, and high costs. Ozone therapy, an investigational approach utilizing ozone’s oxidative and immunomodulatory properties, has emerged as a potential alternative or adjunctive treatment. This review synthesizes evidence on ozone therapy’s mec

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Akyüz, Mehmet, Sultan Uzun, Ali Altındağ, Guldane Magat, and Kaan Orhan. "Corticosteroids and Immunosuppressants on Oral Lichen Planus’ Treatment." European Journal of Therapeutics, May 14, 2024. http://dx.doi.org/10.58600/eurjther2111.

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Dear Editor, Lichen planus (LP), a chronic inflammatory condition primarily targeting skin and mucous membranes, was first outlined by Wilson in 1869 and histologically by Dubreuilh in 1906 [1]. It predominantly affects women in their 4th and 5th decades [2]. Oral lichen planus (OLP) occurs mainly on the buccal mucosa, gingiva, and tongue, presenting in six types, with erosive ones causing eating discomfort. While 25% of LP cases manifest solely orally, some lesions can appear in areas like the anogenital region and esophagus [2]. OLP is postulated to be a T cell-mediated response to antigens,

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Andrist, Caroline Michèle, Lukas Jörg, Thomas Greuter, Anna Gschwend, Alex Straumann, and Arthur Helbling. "Delayed hypersensitivity reaction to orodispersible budesonide in a case with eosinophilic esophagitis." BMC Gastroenterology 20, no. 1 (2020). http://dx.doi.org/10.1186/s12876-020-01554-y.

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Abstract Background Eosinophilic esophagitis (EoE) is a chronic inflammatory disease that has been known since the early 1990s. Swallowed topical corticosteroids (STC) belong to the therapeutic cornerstones. We describe a delayed hypersensitivity reaction to Jorveza®, a newly developed orodispersible budesonide tablet licensed for the treatment of eosinophilic esophagitis. Case presentation A 32-year-old Caucasian woman with EoE was newly treated with Jorveza®. Hours after the first intake, she felt a “strange pruritus” in the throat. This sensation worsened with each subsequent intake. On day

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Jeimy, Samira, Tiffany Wong, Moshe Ben-Shoshan, Ana Maria Copaescu, Ghislaine A. C. Isabwe, and Anne K. Ellis. "Drug allergy." Allergy, Asthma & Clinical Immunology 20, S3 (2025). https://doi.org/10.1186/s13223-024-00936-1.

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Abstract Drug allergy encompasses a spectrum of immunologically-mediated hypersensitivity reactions (HSRs) with varying mechanisms and clinical presentations. This type of adverse drug reaction (ADR) not only affects patient quality of life, but may also lead to delayed treatment, unnecessary investigations, and increased morbidity and mortality. Given the spectrum of symptoms associated with the condition, diagnosis can be challenging. Therefore, referral to an allergist experienced in the diagnosis and management of drug allergy is recommended if a drug-induced allergic reaction is suspected

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Monzani, Alice, Marta Cerutti, Sara Curto, et al. "Eosinophilic esophagitis improved by the discontinuation of sublingual immunotherapy for aeroallergens: a case report." Frontiers in Pediatrics 12 (March 19, 2024). http://dx.doi.org/10.3389/fped.2024.1379162.

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IntroductionEosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammation of the esophagus, characterized by symptoms related to esophageal dysfunction, resulting from severe eosinophilic infiltration of the esophageal mucosa. It is common in atopic subjects and food antigens have been identified as the most common triggers. However, a seasonal variation in EoE prevalence, correlated with air pollen levels, is reported, suggesting that also aeroallergens may play a role. Little is known about the interplay between EoE and concomitant atopy treatment for aeroallergens.Case presentat

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Oliva, Salvatore, Serena Arrigo, Matteo Bramuzzo, et al. "Eosinophilic esophagitis in children and adolescents: a clinical practice guideline." Italian Journal of Pediatrics 51, no. 1 (2025). https://doi.org/10.1186/s13052-025-02056-x.

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Abstract Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition that affects the esophagus and is marked by the presence of eosinophils. This disease is becoming more common in children and adolescents and can result in symptoms like swallowing difficulties, food impaction and abdominal pain. Managing pediatric EoE requires a team effort including gastroenterologists, allergists and dietitians. Medical treatments may include topical corticosteroids, proton pump inhibitors, and elimination diets. Endoscopy plays a key role in the diagnosis, management and monitoring of the condit

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Kumar, Deepak, Sagarika Majhi, and Meenakshi Sharma. "A Review on Psoriasis Pathophysiology, Clinical Appearance, and Pharmacotherapeutic Interventions." Current Indian Science 01 (December 8, 2023). http://dx.doi.org/10.2174/012210299x256032231127060853.

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Abstract: A chronic skin condition called psoriasis can manifest as plaque, flexural, guttate, pustular, and erythrodermic lesions, among other clinical symptoms. Sixty million people are believed to be affected by psoriasis worldwide. In India, the frequency ranges from 0.44 to 2.8%, with males affected two times more frequently than females in their third or fourth decade of life. An immune-mediated inflammation condition with a sizable genetic component is psoriasis. Due to its connection to psoriatic arthritis and the increased prevalence of cardiometabolic, hepatic, and psychiatric proble

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Nidha, Shapoo, Rehman Abdul, Mattana Joseph, Jen-Chin Wang, and Gotlieb Vladimir. "Cemiplimab-Induced Vogt-Koyanagi-Harada-Like Syndrome in a Patient With Cutaneous Squamous Cell Carcinoma of the Lower Back." Journal of Investigative Medicine High Impact Case Reports 13 (June 2025). https://doi.org/10.1177/23247096251355151.

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Cemiplimab is a programmed death receptor-1 inhibitor that has been approved for the treatment of advanced cutaneous squamous cell carcinoma (CSCC). The immune-related adverse events most commonly reported with cemiplimab are thyroiditis, pneumonitis, and hepatitis. Ocular adverse events have been rarely reported. We present a rare case of Vogt-Koyanagi-Harada (VKH)-like syndrome in a patient with CSCC being treated with cemiplimab. A 53-year-old woman presented with bilateral progressive visual disturbances, eye pain, and headache for 4 weeks after 4 cycles of neo-adjuvant cemiplimab therapy

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Ma, Christopher, and Eldon A. Shaffer. "Eosinophilic Oesophagitis: Current Understanding and Future Directions." EMJ Gastroenterology, December 1, 2016, 96–106. http://dx.doi.org/10.33590/emjgastroenterol/10313659.

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Eosinophilic oesophagitis (EoE) is an emerging disorder that manifests clinically with characteristic symptoms of oesophageal dysfunction and histologically by tissue eosinophilia. This chronic immune-mediated oesophageal disease represents a response primarily to food antigens. The incidence of EoE is escalating in both adults and children. This rise stems not only from heightened recognition but also an increased frequency of allergic/atopic diseases and defective immune tolerance. In adults, EoE presents as intermittent solid-food dysphagia or food impaction, heartburn, and chest pain, typi

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Bestué, Ana Pueyo, Ignacio Pueyo‐Bestué, Diego Fernández‐Velasco, et al. ""Tinu‐like syndrome" as a rare adverse effect of nivolumab: A clinical case." Acta Ophthalmologica 103, S284 (2025). https://doi.org/10.1111/aos.17337.

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Aims/Purpose: By presenting this clinical case, our main purpose is to raise awareness of the growing incidence of immune‐related adverse effects (irAEs) with patients undergoing treatments such as Nivolumab.Methods: Presentation of clinical case from our Ophthalmology departmentResults: Our clinical case consists of a patient 66‐year‐old male, presenting pain in both eyes since a couple of days. On examination, in addition to reduced visual acuity (VA) of 6/10 in both eyes, bilateral cellular Tyndall grade 2 was noticed, with no other findings in the anterior or posterior segment. When inquir

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Ghosalkar, E., A. Goldstein, C. Moss, et al. "(002) LONG-TERM PATIENT SATISFACTION FOLLOWING SURGICAL TREATMENT OF CLITORAL PHIMOSIS AND LABIAL ADHESIONS IN LICHEN SCLEROSUS." Journal of Sexual Medicine 22, Supplement_1 (2025). https://doi.org/10.1093/jsxmed/qdaf068.002.

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Abstract Introduction Vulvar lichen sclerosus (LS) is a chronic inflammatory skin condition primarily affecting the anogenital region, leading to scarring, sexual dysfunction, and increased risk of squamous cell carcinoma. The pathophysiology involves immune-mediated fibrosis, causing architectural distortment and functional impairment. Women with LS frequently present with vulvar pain, pruritus, irritation, voiding dysfunction, and sexual dysfunction, with progressive scarring leading to conditions like clitoral phimosis and labial adhesions. Initial interventions typically include topical ul

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