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Journal articles on the topic 'Histoid Leprosy'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

N, SindhuShree. "Clinicopathological study of lepromatous leprosy and histoid leprosy in a tertiary care institute." Journal of Pathology of Nepal 11, no. 1 (2021): 1818–24. http://dx.doi.org/10.3126/jpn.v11i1.31929.

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Background: Lepromatous leprosy is a clinical course seen in patients with inefficient cellular immunity against Mycobacterium leprae, resulting in anergy. A highly bacilliferrous type of lepromatous leprosy is histoid leprosy. Histoid leprosy was initially reported to manifest after the failure of long-term dapsone monotherapy, irregular therapy, or inadequate therapy. However, it is now well known that histoid leprosy develops de-novo as well. This study was undertaken to know the incidence and clinicopathological characteristics of lepromatous leprosy and histoid leprosy.Materials and Metho

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2

Karthikeyan, Kaliaperumal. "Histoid Leprosy." American Journal of Tropical Medicine and Hygiene 92, no. 6 (2015): 1085–86. http://dx.doi.org/10.4269/ajtmh.14-0658.

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3

Rinasari, Umi, Sawitri Sawitri, M. Yulianto Listiawan, et al. "Histoid Leprosy." Indonesian Journal of Tropical and Infectious Disease 1, no. 1 (2010): 27. http://dx.doi.org/10.20473/ijtid.v1i1.3719.

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Histoid Leprosy is a variant of lepromatous leprosy with characteristic clinical and histopathological features. Usually it is occured in lepromatous patients who relaps after dapsone monotherapy, in those with dapsone resistance , sometimes even after multidrug treatment, or at times, de novo with characteristic clinical and histopathological features. A 36 years old male, originated from Papua, visited to the skin outpatient clinic with translucent shiny nodules on the left elbow and thumb for the last 18 months. The nodules were multiple, painless and firm. There were nasal congestion, tick

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4

Sehgal, Virender N., and Govind Srivastava. "Histoid Leprosy." International Journal of Dermatology 24, no. 1 (1985): 286–92. http://dx.doi.org/10.1111/j.1365-4362.1985.tb05468.x.

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5

Sehgal, Virender N., and Govind Srivastava. "Histoid Leprosy." International Journal of Dermatology 24, no. 5 (1985): 286–92. http://dx.doi.org/10.1111/j.1365-4362.1985.tb05783.x.

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6

Murthy, Srinivasa V., Sudha M. Rao, and Keerti Mannan. "De-novo Histoid Leprosy." Journal of Laboratory Physicians 3, no. 02 (2011): 110–12. http://dx.doi.org/10.4103/0974-2727.86844.

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ABSTRACTHistoid leprosy is a rare form of multibacillary leprosy with distinct clinical and histopathological features. It is a variant of lepromatous leprosy. It occurs in lepromatous patients, who relapse after dapsone monotherapy, in the presence of dapsone resistance or at times ′de-novo′. We describe here a case of histoid leprosy, clinically mimicking neurofibromatosis.

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7

International, Journal of Medical Science and Innovative Research (IJMSIR). "De Novo Histoid Leprosy - A Rare Variant of Lepromatous Leprosy." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 5 (2024): 144–47. https://doi.org/10.5281/zenodo.15432012.

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<strong>Abstract</strong> Histoid leprosy (HL) is a rare variant of lepromatous leprosy (LL) which is a highly transmissible disease. Here, we describe a de novo case of histoid leprosy. This variant typically arises in multibacillary patients who have received irregular or insufficient treatment for lepromatous leprosy. Its distinctive clinical presentation makes diagnosis challenging, potentially delaying treatment and contributing to the persistence of the disease as an endemic condition. So biopsy and histopathological examination are essential for the accurate diagnosis of histoid leprosy

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8

Bangaru, H., and Seema Afreen Kazi. "Clinical Study of De novo Histoid Leprosy." Clinical Dermatology Review 9, no. 1 (2025): 59–64. https://doi.org/10.4103/cdr.cdr_82_23.

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Histoid leprosy is an uncommon variant of lepromatous leprosy with a unique clinical presentation with asymptomatic multiple, discrete, shiny, dome-shaped skin-colored to erythematous papules and nodules seen over the face, trunk, extremities, histopathological findings, and a characteristic bacterial morphology that usually follows treatment failure especially after dapsone monotherapy. Occasionally, it occurs de novo without any history of previous inadequate or irregular treatment. In this study, we present a total of 8 cases of histoid leprosy with their clinical and histopathological find

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9

Santhanakrishnaan, Soundarya, and Manjumeena Dakshinamoorthy. "Histoid leprosy, an unusual variant of leprosy − review of literature." Egyptian Journal of Dermatology and Venereology 43, no. 3 (2023): 161–63. http://dx.doi.org/10.4103/ejdv.ejdv_19_22.

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Histoid leprosy is a rare variant of leprosy with distinctive immunological, clinical, microbiological, and histological characteristics first described by Wade in the year 1963. This is usually reported following dapsone monotherapy, irregular or improper therapy, and rarely de novo. Early diagnosis and treatment of histoid is important as it might serve as a reservoir and source of community spread of leprosy. In this article, we highlight the important aspects of clinical manifestations, immunological, histological, bacteriological, and management aspects of histoid leprosy.

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10

Sahi, R., A. Singh, R. Vaidya, GG Swamy, JM Ahuja, and S. Chauhan. "Histoid leprosy: an uncommon variant of lepromatous leprosy." Journal of College of Medical Sciences-Nepal 6, no. 4 (2012): 76–78. http://dx.doi.org/10.3126/jcmsn.v6i4.6733.

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Histoid leprosy is an uncommon variant of lepromatous leprosy with characteristic clinical, immunologic and bacteriologic finding. Histoid leprosy can be eliminated by early diagnosis and complete treatment. Journal of College of Medical Sciences-Nepal,2011,Vol-6,No-4, 76-78 DOI: http://dx.doi.org/10.3126/jcmsn.v6i4.6733

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11

Kalvit, Kushal R. "De novo histoid leprosy in an immunocompetent male: a rare case report from North east India." International Journal of Scientific Reports 5, no. 11 (2019): 338. http://dx.doi.org/10.18203/issn.2454-2156.intjscirep20194650.

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Histoid leprosy is a rare form of lepromatous (multibacillary) leprosy. This form of leprosy is fairly common in patients on dapsone monotherapy and irregular treatment. Sometimes it can arise de novo as well. Very few cases have been reported in immunocompetent individuals from India. I report a case of de novo histoid leprosy in a 22 year old male from north east India.

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12

Mendiratta, Vibhu, Arpita Jain, Ram Chander, Anamita Khan, and Meenu Barara. "A nine-year clinico-epidemiological study of Histoid Hansen in India." Journal of Infection in Developing Countries 5, no. 02 (2011): 128–31. http://dx.doi.org/10.3855/jidc.1190.

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Introduction: Histoid Hansen is rare but a well-defined entity with specific clinical, histopathological, and bacteriological features. The incidence has been reported to vary from 1-2% amongst total leprosy patients. Methodology: We performed a retrospective analysis of the records of patients identified as histoid Hansen on the basis of clinico-histopathological criteria, who attended the Hansen clinic from 2000-2009. Results: A total of 962 leprosy patients attended the Hansen clinic from 2000-2009, and of these, 11 (1.14%) were diagnosed as histoid Hansen. The youngest patient on record wa

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13

Hashmi, S. A., G. S. Bhadauria, K. S. Rajmohan, et al. "HANSEN’S DISEASE DIAGNOSED AFTER ANTI-CANCER CHEMOTHERAPY." International Journal of Medicine and Medical Research 5, no. 2 (2020): 20–24. http://dx.doi.org/10.11603/ijmmr.2413-6077.2019.2.10458.

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Background. Leprosy or Hansen’s disease is a chronic granulomatous disease involving predominantly skin, peripheral nerves and nasal mucosa but capable of affecting any tissue or organ. Histoid leprosy is a very rare well-defined clinicopathological variant of multibacillary lepromatous leprosy, which is very difficult to diagnose due to different specific clinical and histopathological ﬁndings that mimic a ﬁbromatous disorder. Histoid leprosy occurs generally after treatment failure and sometimes de novo. Objective. The aim of the study was to explore histoid leprosy throughout a case r

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14

Pandey, Pooja, MavinrkainahalliSrinivasa Murthy Suresh, and Vivekkumar Dey. "De Novo Histoid Leprosy." Indian Journal of Dermatology 60, no. 5 (2015): 525. http://dx.doi.org/10.4103/0019-5154.159666.

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15

Kantaria, ShaileshM. "De novo histoid leprosy." Indian Dermatology Online Journal 5, no. 4 (2014): 556. http://dx.doi.org/10.4103/2229-5178.142578.

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16

Malik, Nishtha, Pooja Chaurasia, Aravind Reddy, and Shubham Vijay Deokar. "De novo histoid leprosy." BMJ Case Reports 17, no. 7 (2024): e260263. http://dx.doi.org/10.1136/bcr-2024-260263.

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17

KONTOCHRISTOPOULOS, GEORGE J., KYRIAKI ARONI, DEMETRIOS N. PANTELEOS, and ANDRONIKI D. TOSCA. "IMMUNOHISTOCHEMISTRY IN HISTOID LEPROSY." International Journal of Dermatology 34, no. 11 (1995): 777–81. http://dx.doi.org/10.1111/j.1365-4362.1995.tb04396.x.

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18

Nair, S. Pradeep, K. Prasanna Moorthy, Sukumaran Suprakasan, Sabeena Jayapalan, and Gomathy Mini. "Histoid leprosy - unusual presentation." International Journal of Dermatology 45, no. 4 (2006): 433–34. http://dx.doi.org/10.1111/j.1365-4632.2006.02669.x.

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19

Rao, AngooriGnaneshwar. "Borderline tuberculoid leprosy associated with histoid leprosy." Indian Journal of Dermatology 61, no. 5 (2016): 580. http://dx.doi.org/10.4103/0019-5154.190130.

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20

Siddiqui, Moin Ahmad. "De novo Histoid Leprosy of face mimicking Lupus Miliaris Disseminatus Faciei: An uncommon presentation." Afghanistan Journal of Infectious Diseases 2, no. 1 (2024): 103–6. http://dx.doi.org/10.60141/ajid/v.2.i.1.11.

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Background: Background: Histoid leprosy is a rare variant of lepromatous leprosy with distinct clinical features and characteristic histopathology. It is diagnosed using classical histopathological findings and Fite staining, distinguishing it from dermatofibroma and neurofibroma using factor XIIIa and S100 on immunohistochemistry. A middle-aged female presented with facial lesions mimicking Lupus Miliaris Disseminatus Faciei (LMDF). Case report: A 35-year-old female with facial lesions for two months, previously treated with oral isotretinoin for acne vulgaris, presented with multiple papules

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21

Patel, Dhara D., Arpita H. Solanki, and Shankar S. Ganvit. "An unusual ocular presentation of histoid leprosy." International Journal Of Community Medicine And Public Health 8, no. 2 (2021): 841. http://dx.doi.org/10.18203/2394-6040.ijcmph20210249.

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Leprosy is a chronic granulomatous infection caused by mycobacterium leprae, mainly affecting the skin and peripheral nerve. Histoid type of leprosy, which is considered as an extremely rare variant of lepromatous leprosy. We report a case of a 50/year old male presented to our institute with chief complain of conjunctival swelling in both eyes, encroaching over cornea and involving limbus and sclera, associated with painless blurring of vision. An incisional biopsy of the right eye was performed under local anesthesia. Histopathology of right eye biopsy revealed spindle shaped cells having bl

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22

Dimri, Deepak, Bhawna Sethi, and Yogesh Kumar. "De NovoHistoid Leprosy in an Elderly: A Case Report and Review of the Literature." Case Reports in Pathology 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/219421.

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Histoid leprosy, an uncommon variant of lepromatous leprosy, develops usually as relapse in lepromatous patients who are on dapsone monotherapy, but uncommonly arisesde novo. This rare form of the disease, with unique clinical and histopathological features, may pose a diagnostic challenge even to astute clinicians. We report the case that occurredde novoin an elderly who presented with small to large lesions all over the body. A fresh focus on histoid leprosy is the primary objective of this paper, especially in the context of the postglobal leprosy elimination era.

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23

Annigeri, SR, SC Metgud, and JR Patil. "Lepromatous leprosy of histoid type." Indian Journal of Medical Microbiology 25, no. 1 (2007): 70. http://dx.doi.org/10.4103/0255-0857.31069.

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24

Annigeri, SR, SC Metgud, and JR Patil. "LEPROMATOUS LEPROSY OF HISTOID TYPE." Indian Journal of Medical Microbiology 25, no. 1 (2007): 70–71. http://dx.doi.org/10.1016/s0255-0857(21)02241-6.

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25

Pokhrel, K., R. Ghimire, and S. Subedi. "Histoid leprosy with ENL reaction." Nepal Journal of Dermatology, Venereology & Leprology 11, no. 1 (2013): 70–72. http://dx.doi.org/10.3126/njdvl.v11i1.7938.

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26

Pandhi, D., BSN Reddy, N. Khurana, and S. Agarwal. "Nodular syphilis mimicking histoid leprosy." Journal of the European Academy of Dermatology and Venereology 19, no. 2 (2005): 256–57. http://dx.doi.org/10.1111/j.1468-3083.2005.00972.x.

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27

Janniger, Camila Krysicka, Rajendra Kapila, Robert A. Schwarts, William R. Levis, and W. Clark Lambert. "Histoid Lepromas of Lepromatous Leprosy." International Journal of Dermatology 29, no. 7 (1990): 494–96. http://dx.doi.org/10.1111/j.1365-4362.1990.tb04842.x.

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28

GUPTA, CM, SK SAYAL, AK MALIK, and ND ROY. "HISTOID RELAPSE IN LEPROMATOUS LEPROSY." Medical Journal Armed Forces India 54, no. 2 (1998): 173. http://dx.doi.org/10.1016/s0377-1237(17)30519-1.

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29

MARQUES, VANESSA TONETTO, NAIARA PRISCILA QUALIO, GIOVANI ANTÔNIO RODRIGUES, et al. "HISTOID LEPROSY WITH ORAL MANIFESTATION." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 124, no. 2 (2017): e78. http://dx.doi.org/10.1016/j.oooo.2017.05.097.

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30

Kumar, Vijay, Vibhu Mendiratta, Ravi C. Sharma, Nirupama Kakar, and Promila Bajaj. "Erythema Nodosum Leprosum in Histoid Leprosy: A Case Report." Journal of Dermatology 24, no. 9 (1997): 611–14. http://dx.doi.org/10.1111/j.1346-8138.1997.tb02302.x.

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31

M., Kaveri, and Vishal V. Wali. "Clinico-pathological study of cases of histoid leprosy." International Journal of Research in Dermatology 6, no. 4 (2020): 474. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20202650.

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<p class="abstract"><strong>Background:</strong> Rare variants of leprosy pose a diagnostic challenge and histoid leprosy is one such form of disease with unique clinical and histopathological features. The objective of the study was to study clinical and histopathological features of histoid leprosy.</p><p class="abstract"><strong>Methods:</strong> A prospective observational study was conducted at M. R. Medical College and Basveshwar teaching and general hospital, Kalaburagi from July 2018 to October 2019. Newly diagnosed and histologically proven ca

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32

Andrade, Pedro Jose Secchin de, Sulamita dos Santos Nascimento Dutra Messias, Paola Cristina Brandão Oliveira Ferreira, Anna Maria Sales, Alice de Miranda Machado, and José Augusto da Costa Nery. "Histoid leprosy: a rare exuberant case." Anais Brasileiros de Dermatologia 90, no. 5 (2015): 756–57. http://dx.doi.org/10.1590/abd1806-4841.20154049.

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33

Kaliyadan, Feroze, MalayilJ Cyriac, and AndezthuD Dharmaratnam. "Histoid leprosy with penile shaft lesions." Indian Dermatology Online Journal 3, no. 1 (2012): 68. http://dx.doi.org/10.4103/2229-5178.93485.

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34

Bauer, Angélica, Letícia Maria Eidt, Renan Rangel Bonamigo, and Renata Heck. "Histoid leprosy - A rare clinical presentation." Anais Brasileiros de Dermatologia 96, no. 5 (2021): 598–601. http://dx.doi.org/10.1016/j.abd.2021.02.003.

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35

Wali, Vishal. "Histoid leprosy: Clinical and pathological corelation." MedPulse International Journal of Medicine 19, no. 1 (2021): 24–28. http://dx.doi.org/10.26611/10211916.

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36

Maroja, Maria De Fatima, Cesare Massone, and Antonio Pedro Schettini. "Histoid leprosy with Type 1 reaction." Leprosy Review 87, no. 3 (2016): 417–24. http://dx.doi.org/10.47276/lr.87.3.417.

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37

Gupta, Sunil Kumar. "Histoid leprosy: review of the literature." International Journal of Dermatology 54, no. 11 (2015): 1283–88. http://dx.doi.org/10.1111/ijd.12799.

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38

Vinay, Keshavamurthy, Tarun Narang, Chougule Abhijit, and Sunil Dogra. "Unilateral nipple involvement in histoid leprosy." International Journal of Dermatology 54, no. 11 (2015): 1289–90. http://dx.doi.org/10.1111/ijd.13021.

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39

Pereyra, Susana B., Cristián A. Danielo, Gustavo J. Ponssa, Javier E. Consigli, Mariana B. Papa, and Graciela Ghirardi. "Wade's histoid leprosy: three clinical presentations." International Journal of Dermatology 46, no. 9 (2007): 944–46. http://dx.doi.org/10.1111/j.1365-4632.2007.03233.x.

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40

Pathania, Vikas, Jatinder Singh, Anwita Sinha, Rohit Kothari, Sukriti Baveja, and Prerna Shankar. "Are We Witnessing a Paradigm Shift in Leprosy." International Journal of Mycobacteriology 9, no. 1 (2020): 103–6. http://dx.doi.org/10.4103/ijmy.ijmy_187_19.

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Hansen's disease is a chronic infectious granulomatous disease with varied clinical presentation. In the postelimination era, histoid Hansen's disease is an important emerging lepromatous subset known to mimic varied dermatoses, thereby making clinical diagnosis difficult and often delayed. We report two cases of histoid Hansen's disease bereft of clinical cardinal signs of leprosy.

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41

Paudyal, P., S. Shrestha, M. Agarwal, et al. "Histoid leprosy on scrotal skin: an unusual case." International Journal of Infection and Microbiology 2, no. 2 (2013): 64–67. http://dx.doi.org/10.3126/ijim.v2i2.8325.

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INTRODUCTION: Although no part of the skin is immune from invasion by mycobacterium leprae it is commonly seen over cooler parts of the body and very rarely found over external genitalia because of their warm temperature. Histoid leprosy is rare but a well-defined entity with specific clinical, histopathological, and bacteriological features. CASE REPORT: A Punch biopsy measuring 3x3 cm of a 73 year old male having an erythematous plaque over scrotum since 2 months was received for histopathologic examination with the clinical differentials of pilomatrixoma and steatocystoma multiplex. Histopa

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42

Sehgal, Virendra N., Ashok Aggarwal, Govind Srivastava, Neelima Sharma, and Sonal Sharma. "Evolution of histoid leprosy (de novo) in lepromatous (multibacillary) leprosy." International Journal of Dermatology 44, no. 7 (2005): 576–78. http://dx.doi.org/10.1111/j.1365-4632.2004.02540.x.

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43

Gadhe, Anandi, Jay Dhirajlal Modha, Bharti K. Patel, and Neela V. Bhuptani. "A case series of sweet syndrome like erythema nodosum leprosum at tertiary care centrein Western India." IP Indian Journal of Clinical and Experimental Dermatology 10, no. 2 (2024): 229–34. http://dx.doi.org/10.18231/j.ijced.2024.041.

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Leprosy is a chronic disease caused by Mycobacterium Leprae, mainly affecting skin and nerves. Chronic course of leprosy may be interrupted by acute inflammatory conditions called lepra reactions. Type 2 reaction (Erythema Nododsum Leprosum/ENL) classically presents as crops of multiple tender, evanescent nodules. Several pleomorphic variants of ENL has been described in the literature such as erythema necroticans, sweet syndrome–like, erythema multiforme like, livedoreticularis like and bullous ENL. Identification of unusual cutaneous features of ENL are of paramount importance ,which poses a

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44

Calvache, N., D. A. Arias, and V. M. Delgado. "Histoid Leprosy: An Enemy Not Yet Eradicated." Actas Dermo-Sifiliográficas (English Edition) 112, no. 3 (2021): 280–81. http://dx.doi.org/10.1016/j.adengl.2021.01.019.

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45

da Costa, Daniela A. M., Mílvia M. S. S. Enokihara, Suely Nonogaki, Solange M. Maeda, Adriana M. Porro, and Jane Tomimori. "Wade histoid Leprosy: histological and immunohistochemical analysis." Leprosy Review 84, no. 3 (2013): 176–85. http://dx.doi.org/10.47276/lr.84.3.176.

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46

Dandekeri, Sukumar, HyacinthPeter Pinto, MK Srinath, and RameshM Bhat. "Histoid leprosy in the era of elimination." Muller Journal of Medical Sciences and Research 4, no. 1 (2013): 29. http://dx.doi.org/10.4103/0975-9727.112275.

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47

Singh, Nidhi, Rashmi Kumari, Divya Gupta, Devinder Mohan Thappa, and Rajesh Nachiappa Ganesh. "Type 1 lepra reaction in histoid leprosy." International Journal of Dermatology 54, no. 5 (2014): 564–67. http://dx.doi.org/10.1111/ijd.12701.

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48

Sehgal, Virendra N., Govind Srivastava, and Vinay K. Sharma. "Immune Responses in Disseminated Necrotizing Histoid Leprosy." International Journal of Dermatology 27, no. 6 (1988): 413–14. http://dx.doi.org/10.1111/j.1365-4362.1988.tb02392.x.

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49

Nigam, Pramod K., and Gurmohan Singh. "Mucosal and Genital Lesions in Histoid Leprosy." International Journal of Dermatology 29, no. 3 (1990): 207–8. http://dx.doi.org/10.1111/j.1365-4362.1990.tb03802.x.

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50

Zhang, Guiying, Hui Jin, Huan Chen, and Qianjin Lu. "Cutaneous nodules with positive autoantibodies: histoid leprosy." Lancet 386, no. 10006 (2015): 1915–16. http://dx.doi.org/10.1016/s0140-6736(15)00678-9.

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