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Journal articles on the topic 'Histological diagnostics'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Grigoruk, O. G., T. A. Moskvina, D. A. Tsoy, et al. "Endocervical adenocarcinomas. Cytological, histological, and molecular diagnostics." Tumors of female reproductive system 18, no. 2 (2022): 109–18. http://dx.doi.org/10.17650/1994-4098-2022-18-2-109-118.

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This study was undertaken to analyze the effectiveness of cytological diagnostics of endocervical adenocarcinomas. We compared conventional liquid-based cytology, histology, immunohistochemistry, and molecular testing. A total of 25 endocervical adenocarcinomas, including endocervical adenocarcinomas in situ, were diagnosed using cytological methods over a year. Liquid-based cytology ensured better detection of glandular differentiation signs than conventional cytology. After molecular testing for human papillomavirus (HPV), we performed retrospective analysis of cytological characteristics of

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Grigoruk, O. G., E. Yu Bychkova, E. S. Sigitova, et al. "Adenocystic cancer diagnostics : cytological, histological and immunohistochemical." Russian Journal of Oncology 18, no. 4 (2013): 37–38. http://dx.doi.org/10.17816/onco40051.

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3

Liskina, I. V., O. O. Melnyk, S. D. Kuzovkova, and L. M. Zahaba. "Bening solitary pulmonary necrotic focal lesions: possibilities of morphological diagnostics." Tuberculosis, Lung Diseases, HIV Infection, no. 2 (June 15, 2023): 21–27. http://dx.doi.org/10.30978/tb-2023-2-21.

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Objective — to analyze the diagnostic possibilities of histological examination of single necrotized focal lung lesions by determining their histological features and etiology. Materials and methods. The study was conducted as a cohort, retrospective. The group included 68 patients with solitary focal lesions of the lungs (from 1 to 3), the size of each focus did not exceed 3 cm. The size, shape and contours of the detected foci were evaluated based on the results of radiographs or tomograms. Morphological diagnostics included cytological and histological examination. The results of microbiolo

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LZ, Gbaa, Ojo BA, Eke BA, et al. "Colorectal and Anal Malignancies in Makurdi, North Centra Nigeria: Insights from a 10-Year Registry Analysis." Asian Journal of Medicine and Health 23, no. 6 (2025): 196–203. https://doi.org/10.9734/ajmah/2025/v23i61254.

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Colorectal and anal cancers (CRACs) are increasingly reported in sub-Saharan Africa due to rising life expectancy, dietary shifts, and improved diagnostics. This study presents a 10-year review of CRACs in Makurdi, North Central Nigeria, analysing demographic, anatomical, and histological patterns. A retrospective review was conducted of histologically confirmed CRAC cases from January 1, 2016, to December 31, 2024. Data on age, sex, anatomical site, and histological subtype were analysed using descriptive statistics. We had a total of 2341 cancers, 129 (5.5%) of which were CRACs. Males consti

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Rama Rao, Tadikonda, Afshaan Tabassum, Hafsa Sharmeen, and Sena Jessy Jasmine. "Challenging Diagnosis of Intestinal Tuberculosis: A Review." International Journal of Science and Healthcare Research 9, no. 4 (2024): 317–29. https://doi.org/10.52403/ijshr.20240438.

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Intestinal tuberculosis (ITB), a subset of extrapulmonary tuberculosis (EPTB), arises from Mycobacterium tuberculosis infection, primarily affecting the ileocecal region due to its lymphatic tissue richness. Representing approximately 10% of global EPTB cases, ITB is most prevalent in regions with high tuberculosis (TB) incidence. Its nonspecific symptoms—abdominal pain, diarrhea, fever, and weight loss—pose significant diagnostic challenges and frequently overlap with conditions like Crohn’s disease (CD). This diagnostic complexity is compounded by shared clinical, endoscopic, and histologica

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Padure, Andrei, Oksana Bakun, Ivan Mikirin, et al. "DIFFERENTIAL MUELLER-MATRIX MAPPING OF THE POLYCRYSTALLINE COMPONENT OF BIOLOGICAL TISSUES OF HUMAN ORGANS." Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska 14, no. 4 (2024): 23–27. https://doi.org/10.35784/iapgos.6211.

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The article presents the materials of diagnostic application of the method of differential Mueller-matrix mapping of optically anisotropic architectonics of the layers of soft matter of the female reproductive sphere – histological sections of uterine biopsy. The efficiency and accuracy of differential diagnostics of benign and precancerous conditions of endometrial tissue are considered using statistical analysis of algorithmically reproduced maps of average values of linear and circular birefringence and dichroism parameters of optically anisotropic architectonics of representative samples o

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Gromov, I. N. "Noinfectious diseases in industrial poultry farming: histological diagnostics." Agrarian science 344, no. 1 (2021): 15–17. http://dx.doi.org/10.32634/0869-8155-2021-344-1-15-17.

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Under conditions of egg and poultry farming noninfectious diseases are widespread and cause significant economic damage. These diseases can be caused by a variety of etiological factors: the deficiency of the necessary chemical elements, substances or their combination, excessive amount of certain classes of organic substances in feed. Diseases of complex etiology are also recorded, which arise from a combination of unfavorable factors and anatomical and physiological properties of individual bird crosses. Under the influence of unfavorable factors in various organ systems, pathological proces

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Fedulova, M. V., D. V. Bogomolov, D. D. Kupriyanov, and A. N. Safronova. "Role of Kraevsky cells in forensic histological diagnostics." Sudebno-meditsinskaya ekspertiza 66, no. 1 (2023): 55. http://dx.doi.org/10.17116/sudmed20236601155.

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9

Takao, Toshitatsu, Takeshi Ishikawa, Takashi Ando, et al. "Multifaceted Assessment of Chronic Gastritis: A Study of Correlations between Serological, Endoscopic, and Histological Diagnostics." Gastroenterology Research and Practice 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/631461.

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Aim. Chronic gastritis was assessed serologically, endoscopically and histologically to identify correlations between these methods.Methods. Subjects comprised 319 patients who had provided informed consent. Serological assessment of chronic gastritis was based on the pepsinogen test method. Endoscopic gastritis and histological gastritis were assessed and scored according to the Kimura-Takemoto classification system and the updated Sydney classification system respectively, and correlations between these three methods were studied.Results. Pepsinogen I/II ratio showed a significant correlatio

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10

SAMTSOV, A. V., V. V. BARBINOV, D. A. RESHETNIK, I. K. MINULIN, G. V. BOGDANOV, and M. K. KAVOKIN. "Organization of histological diagnostics of dermatoses with the use of video and information technologies." Vestnik dermatologii i venerologii 88, no. 6 (2012): 11–19. http://dx.doi.org/10.25208/vdv749.

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Objective. To assess the efficacy of activities carried out by a dermatovenerology dispensary after the implementation of histological diagnostics of dermatoses with the use of the HISTODERM partner expert system. Materials and methods. The authors studied the results of activities carried out by two dermatovenerology dispensaries (in Surgut and Kazan) where histological diagnostics was implemented on the basis of the HISTODERM partner expert system. A dermatovenerologist used the system in the first institution while an anatomic pathologist used it in the second institution. Results. The qual

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11

Drozhdina, M. V., and S. V. Koshkin. "View of the clinic, diagnosis and treatment of familial benign pemphigus (Hailey — Hailey disease). Literature review." Vestnik dermatologii i venerologii 94, no. 4 (2018): 7–14. http://dx.doi.org/10.25208/0042-4609-2018-94-4-7-14.

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The article describes modern views on predisposing factors, histological and genetic changes, the role of ATP2C1 encoding a mutant gene, localized on chromosome 3 in the pathogenesis of Hailey — Hailey disease. Diagnostic criteria, differential diagnostics with other diseases and methods of modern treatment of this disease are presented.

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12

Sumtsov, D. G., I. Z. Gladchuk, G. O. Sumtsov, et al. "Problems of primary fallopian tube cancer diagnostics during and after surgery." REPRODUCTIVE ENDOCRINOLOGY, no. 59 (July 22, 2021): 66–71. http://dx.doi.org/10.18370/2309-4117.2021.59.66-71.

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To date, the reliable diagnoses primary fallopian tube cancer (PFTC) before surgery range from 0% to 10–15%. Number of misdiagnosis even during operations reaches 30–50% and PFTC is often disguised as innocent hydro-hematosalpinx or other diseases.Research objective: to study the possibilities of PFTC diagnosis during laparotomy and laparoscopy, macroscopic examination of removed macrodrugs, suboperative use of morphological studies, problems of histological interpretation of PFTC after surgery.Materials and methods. During the period from 1966 to 2020 authors of article selected and retrospec

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D.G., Sumtsov, Gladchuk I.Z., Sumtsov G.O., et al. "Problems of primary fallopian tube cancer diagnostics during and after surgery." REPRODUCTIVE ENDOCRINOLOGY, no. 59 (July 22, 2021): 66–71. https://doi.org/10.18370/2309-4117.2021.59.66-71.

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To date, the reliable diagnoses primary fallopian tube cancer (PFTC) before surgery range from 0% to 10–15%. Number of misdiagnosis even during operations reaches 30–50% and PFTC is often disguised as innocent hydro-hematosalpinx or other diseases. <strong>Research objective:</strong> to study the possibilities of PFTC diagnosis during laparotomy and laparoscopy, macroscopic examination of removed macrodrugs, suboperative use of morphological studies, problems of histological interpretation of PFTC after surgery. <strong>Materials and methods.</strong> During the period f

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14

Laenger, Florian Peter, Nicolaus Schwerk, Jens Dingemann, et al. "Interstitial lung disease in infancy and early childhood: a clinicopathological primer." European Respiratory Review 31, no. 163 (2022): 210251. http://dx.doi.org/10.1183/16000617.0251-2021.

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Children's interstitial lung disease (chILD) encompasses a wide and heterogeneous spectrum of diseases substantially different from that of adults. Established classification systems divide chILD into conditions more prevalent in infancy and other conditions occurring at any age. This categorisation is based on a multidisciplinary approach including clinical, radiological, genetic and histological findings. The diagnostic evaluation may include lung biopsies if other diagnostic approaches failed to identify a precise chILD entity, or if severe or refractory respiratory distress of unknown caus

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Vanovčanová, Lucia, and Eva Mináriková. "An updated perspective on diagnostics and treatment of idiopathic granulomatous mastitis." Česká gynekologie 88, no. 6 (2023): 435–41. http://dx.doi.org/10.48095/cccg2023435.

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Aim: To present our experiences with the anti-inflammatory treatment of idiopathic granulomatous mastitis (IGM) and highlight the imaging and anamnestic specifics of its diagnosis. Methods: Patients with acute inflammatory breast disease underwent ultrasound examination followed by a collection of anamnestic data, and histological analysis of the process was performed using core-cut biopsy, confirming IGM. Subsequently, anti-inflammatory treatment was administered, consisting of a combination of colchicine, vitamin E, and local compresses made from an infusion of Plantago lanceolata. We also r

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Yang, Desong, Xiaolong Sheng, Lianghui Gong, Xun Wu, Jinming Tang, and Wenxiang Wang. "Distinguishing MPLCs from IPMs using NGS-based molecular algorithms and histological assessment: A systematic review and validation study." Medicine 104, no. 8 (2025): e41673. https://doi.org/10.1097/md.0000000000041673.

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Distinguishing between multiple primary lung cancers and intrapulmonary metastases is crucial for staging, therapeutic planning, and prognosis. Traditional histological assessment provides a foundation for diagnosis, which can be limited when tumors showed identical or similar histological types. This systematic review and independent validation study aimed to evaluate the performance of next-generation sequencing (NGS)-based molecular algorithms alongside histological methods for the classification of multiple lung adenocarcinomas (MLAs). We conducted a literature search to identify relevant

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17

Kurkina, A. "Anatomical and morphological diagnostics of Tanacetum vulgare L. flowers." Modern Phytomorphology 4 (April 1, 2013): 245–48. https://doi.org/10.5281/zenodo.161387.

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The morphological, histological and microscopical investigations on tansy Tanacetum vulgare L. flowers were carried out. For the first time were studied the microscopic and histological structures of the inflorescence (the basket) of T. vulgare, its flowers and diagnostic signs are revealed. There were observed the presence of the layer of sclerenchyma in the mesophyll of the inflorescence spathe. For the first time were described the morphological and anatomical characteristics of the structure of the fertile part of the tubular flower, flower stalk and leaflets, which compose corymbiform inf

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18

Berchenko, Gennadiy N., Nina V. Fedosova, Mikhail G. Kochan, and Dmitriy V. Mashoshin. "Neural network model development for detecting atypical mitoses in histological slides." N.N. Priorov Journal of Traumatology and Orthopedics 31, no. 3 (2024): 337–50. http://dx.doi.org/10.17816/vto626361.

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Background: Modern computer systems allow digitizing and examining images of histological preparations, which led the authors to the idea of using machine learning tools in digital pathohistology. The ability of neural networks to find sub-visual image features in digitized histological preparations provides the basis for better qualitative and quantitative image analysis. Existing machine learning methods provide good accuracy and speed in recognizing various images, which gives hope for their wide application, including in oncologic diagnostics. AIM: Use methods of mathematical modeling to i

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19

Intriago, Pablo, Bolivar Montiel, Mauricio Valarezo, et al. "Co-Infection Dynamics of Baculovirus Penaei (BP–PvSNPV) in Penaeus vannamei Across Latin America." Viruses 17, no. 3 (2025): 374. https://doi.org/10.3390/v17030374.

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Baculovirus penaei (BP) is an enteric virus infecting the hepatopancreas and anterior midgut of shrimp, particularly affecting early developmental stages and contributing to hatchery losses. While BP’s role in co-infections is increasingly recognized, its impact on later life stages remains unclear. Despite advancements in molecular diagnostics, its high genetic diversity complicates reliable detection, often leading to discrepancies between PCR results and histological observations of occlusion bodies. This study evaluated seven primer pairs for BP detection in Penaeus vannamei. Among histolo

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20

Lisova, V., and N. Radsikhovskii. "Pathomorphological diagnostics of enteritis of viral etiology in dogs." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 20, no. 83 (2018): 299–303. http://dx.doi.org/10.15421/nvlvet8360.

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The article presents the results of the study of pathomorphological changes in organs and tissues of dogs at parvovirus and coronavirus infections. The pathoanatomical section and histological examination of pathological material selected from cadavers of dogs of different breeds and sex between 2 to 6 months who died with signs of infectious diarrhea were conducted. Pathomorphological study was performed only on cadavers of animals in which the life using PCR in stool specimens was established clinical diagnosis – parvovirus enteritis (n = 13) and coronavirus enteritis (n = 7). After selectio

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Bychkova, E. Yu, Olga G. Grigoruk, D. O. Kuratov, E. A. Afanasieva, L. M. Bazulina, and N. A. Bykova. "Uncommon case of the acral melanoma with chondro-osseous metaplasia." Russian Journal of Oncology 25, no. 6 (2020): 208–12. http://dx.doi.org/10.17816/1028-9984-2020-25-6-208-212.

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Aim. This study aimed to improve the diagnostics of acral melanoma and investigate tumor morphological features of the chondroid and osseous matrix. Materials and methods. The article presents a clinical case of metastatic acral melanoma with chondroid and osseous metaplasia in a 60-year-old patient. Cytological, histologic, immunohistochemical, and molecular genetic studies were performed. Results. A conglomerate of lymph nodes was noted in the inguinal region of the patient. Oxyphilic chondroid masses and tumor cells with morphological features of sarcoma were revealed using thin

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Bychkova, E. Yu, Olga G. Grigoruk, D. O. Kuratov, E. A. Afanasieva, L. M. Bazulina, and N. A. Bykova. "Uncommon case of the acral melanoma with chondro-osseous metaplasia." Russian Journal of Oncology 25, no. 6 (2020): 208–12. http://dx.doi.org/10.17816/1028-9984-2020-25-6-208-212.

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Aim. This study aimed to improve the diagnostics of acral melanoma and investigate tumor morphological features of the chondroid and osseous matrix. Materials and methods. The article presents a clinical case of metastatic acral melanoma with chondroid and osseous metaplasia in a 60-year-old patient. Cytological, histologic, immunohistochemical, and molecular genetic studies were performed. Results. A conglomerate of lymph nodes was noted in the inguinal region of the patient. Oxyphilic chondroid masses and tumor cells with morphological features of sarcoma were revealed using thin

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23

Ondrášik, Ivan, Janka Filická, Katarína Ondrášiková, and Miriam Tupá. "Laboratórna diagnostika akútnej myeloblastovej leukémie." Zdravotnícke štúdie 14, no. 2 (2022): 52–56. http://dx.doi.org/10.54937/zs.2022.14.2.52-56.

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The aim of the article is to approximate the possibilities of current laboratory diagnostics of acute myeloblastic leukemia (AML). AML diagnosis includes morphological, histological, immunofernotyping and molecular-biological parameters. We focus primarily on the morphological diagnostics of AML.

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Drews-Elger, Katherine, and Erik A. Williams. "Mesenchymal Tumors of the Skin: A Review." Advances in Anatomic Pathology 31, no. 6 (2024): 442–50. http://dx.doi.org/10.1097/pap.0000000000000465.

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Mesenchymal tumors of the skin are rare and clinically heterogeneous, and can represent diagnostic challenge for pathologists. Most of these lesions have overlapping clinical and histological features, thus the understanding of architectural patterns, cytoplasmic and stromal features can facilitate proper diagnosis. Anatomic site may be an important factor in the differential diagnosis, as are patient’s age and sex. Ancillary tests are often required and can be useful to rule out other entities. Molecular diagnostics is playing an increasingly important role in the diagnosis of soft tissue neo

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Novikov, Yuri A., Denis V. Zaslavsky, Olga V. Pravdina, et al. "During’s herpetiform dermatitis in pediatric dermatology: issues of diagnostics and treatment." Pediatrician (St. Petersburg) 11, no. 6 (2020): 79–86. http://dx.doi.org/10.17816/ped11679-86.

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This article presents a case of clinical observation of a 5-year-old child with herpetiformis dermatitis (Duhrings). This rare dermatosis is characterized by a chronic relapsing course, the presence of itching polymorphic rashes, typical histological and immunomorphological signs. The diagnosis was made on the basis of the clinical picture, histological and immunohistochemical studies of skin biopsy, as well as the results of HLA typing by PCR. Clinical observation of this case is of interest to practicing physicians-dermatologists due to the rare occurrence of Duhrings herpetiformis in childr

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Kubanov, A. A., L. F. Znamenskaya, and T. V. Abramova. "Differential diagnostics of bullous dermatoses." Vestnik dermatologii i venerologii 92, no. 6 (2016): 43–56. http://dx.doi.org/10.25208/0042-4609-2016-92-6-43-56.

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Bullous dermatoses are the diseases characterized by vesication and erosion of skin and/or mucos coats, production of autoantibodies against the structural components of epidermis and/or derma. The most frequent diseases of these disorders are pemphigus, bullous pemphigoid, dermatitis herpetiformis, beningn familial chronic pemphigus (Gougerot Hailey-Hailey disease).Diagnostics of bullous dermatoses is based on assessement of clinical signs, results of cytological and histological studies and immunological tests. However none of the current diagnostic methods allows to reveal bullous dermatosi

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Mollin, Edward, and Andrzej Skorek. "Diagnostic and therapeutic difficulties in the case of angiomatous polyps of the paranasal sinuses. Case presentation." Polski Przegląd Otorynolaryngologiczny 7, no. 4 (2018): 1–5. http://dx.doi.org/10.5604/01.3001.0012.7838.

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Preface: angiomatous nasal type polyps (SAP ‒ sinonasal angiomatous polyp) are benign lesions. The clinical and radiological picture of SAP may suggest other diseases of the nose and paranasal sinuses. Diagnostic imaging is based on computed tomography and magnetic resonance. SAP treatment involves their surgical removal. A case report: he aim of the study is to present diagnostic and therapeutic difficulties in a 17-year-old female patient with an inflammatory polyposis of the angiomatous of the paranasal sinuses. The course of disease, diagnostic difficulties and its treatment are presented.

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Filippova, A.Yu. "Diagnostics of progression of liver fibrosis in patients with non-alcoholic steatohepatitis combined with obesity and chronic calculous cholecystitis." Medicni perspektivi 25, no. 1 (2020): 65–73. https://doi.org/10.5281/zenodo.3953944.

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The aim of the work is to investigate the diagnostic value of laboratory blood biomarkers – alanine aminotransferase, aspartate aminotransferase, oxyproline and prothrombin time in comparison with morphological indicators for diagnosis of the degree of liver fibrosis in patients with comorbid course of non-alcoholic steatohepatitis (NASH) combined with obesity and chronic calculous cholecystitis. The data of 22 patients with NASH combined with obesity and chronic calculous cholecystitis was analyzed by laboratory and morphological indicators. There were 6 (27.2%) men and 16 (72.8%) women

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Kornevs, Egils. "Diagnostics and Treatment Strategies of Early (T1) Lower Lip Cancer." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 74, no. 1 (2020): 48–52. http://dx.doi.org/10.2478/prolas-2020-0007.

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AbstractData from 35 patients were analysed to identify the main factors that may have predisposed the unfavourable clinical course in early diagnosed lower lip cancer. Of 35 patients who were sent to the Oncology Centre of Latvia, Rīga East University Hospital, with the diagnosis of early lower lip cancer, histologically diagnosis was confirmed for 22 patients. Sizes of the primary tumours were less than 2 cm (T1 size tumour). Vermilionectomy was carried out for 17 patients, wedge- or V-shaped resection was performed for 13 patients, and in five cases patients refused to receive surgical trea

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Baskakov, V. P., J. V. Tsveliov, and N. N. Ruchliada. "Problem of the contemporary diagnostics of womb adenomyosis." Journal of obstetrics and women's diseases 51, no. 1 (2002): 105–11. http://dx.doi.org/10.17816/jowd90067.

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This article is dedicated to the review of contemporary methods of womb adenomyosis. Authors have performed the analysis of literature data about diagnostic informationness of various histological verification disease methods and have determined main tendencies of these methods improvement, have discussed perspectives.

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Ellinidi, Vera N., Andrey A. Feoktistov, Aleksandra V. Lyamina, Diana M. Obidnyak, and Inna Y. Suvorova. "Chronic polypoid and lymphofollicular endometritis: hysteroscopic and histologycal diagnostic." Journal of obstetrics and women's diseases 66, no. 6 (2017): 59–65. http://dx.doi.org/10.17816/jowd66659-65.

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Complex clinic-morphological study of uterine cavity scraping and a comparative hysteroscopic study of 964 women with infertility and unsuccessful IVF attemps were carried out. For the first time two prognostically meaningful clinic-morphological forms of chronic endometritis-polypoid and lymphofollicular are described. Specific features of their typical gradual morphogenesis and features of chronicity of diagnostic value are established. An algorithm for histological and hysteroscopic diagnostics is introduced.

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Zhukov, A. S., I. E. Belousova, and A. V. Samtsov. "Immunohistochemistry method and diagnostics of mycosis fungoides." Vestnik dermatologii i venerologii 90, no. 2 (2014): 38–46. http://dx.doi.org/10.25208/0042-4609-2014-90-2-38-46.

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Clinical patient examinations are not enough for diagnosing lymphoproliferative skin diseases now. Histological diagnostics is an important auxiliary method; however, it is not always applicable. PCR is not a universal method for determining the clonality of infiltrate cells. The article describes present-day diagnostics methods with an emphasis on the immunohistochemistry method making it possible to identify the cell composition of affected skin.

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Malovrh, Tadej, and Peter Hostnik. "Diagnostics procedures in rabies." Veterinarski glasnik 59, no. 1-2 (2005): 99–105. http://dx.doi.org/10.2298/vetgl0502099m.

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Rabies is a major zoonosis for which diagnostic techniques can only be performed in the laboratory. Laboratory techniques are preferably oriented on tissue removed from the cranium: hippocampus (Ammon's horn), cerebellum and the medulla oblongata or tissue liquids. Clinical observation may only lead to a suspicion of rabies. The only way to perform a reliable diagnosis of the disease is to identify the virus or some of its specific components using laboratory tests such as histological identification of characteristic cell lesions, immunochemical identification of rabies virus antigen and viru

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Baranovska, V. V., A. M. Romanenko, and L. M. Zakhartseva. "HISTOLOGICAL FEATURES OF CHROMOPHOBE RENAL CELL CARCINOMA." Eastern Ukrainian Medical Journal 8, no. 1 (2020): 15–23. http://dx.doi.org/10.21272/eumj.2020;8(1):15-23.

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Introduction. Renal neoplasms are a common disease. Differential diagnostics of different tumor subtypes for prognosis and treatment is necessary given that some of them, like renal cell oncocytomas, are benign, and others, like chromophobe renal cell carcinomas, are malignant. Unfortunately, the histological similarity between these tumors makes accurate diagnostics difficult. In some cases, additional diagnostic methods such as immunohistochemistry should be used. The aim of our study is to analyze the histological characteristics of chromophobe renal cell carcinomas and renal oncocytomas, i

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Ciochon, Urszula Maria, Grethe Schmidt, Ruben Juhl Jensen, Anand C. Loya, Lars Birger Lönn, and Nitesh Shekhrajka. "Preoperative Embolization of a Solitary Fibrous Tumor Originating from External Auditory Meatus: A Case Report with Literature Review." Diagnostics 11, no. 1 (2021): 62. http://dx.doi.org/10.3390/diagnostics11010062.

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Solitary fibrous tumors (SFTs) are mesenchymal, fibroblastic tumors with mostly favorable, but still unpredictable prognosis. Their rarity and occurrence at a variety of locations coupled with variable histological appearance make the diagnosis a challenge. This can be resolved by histological and immunohistochemical analysis on the histologic material eventually coupled with demonstration of NAB2-STAT6 gene fusion by next generation sequencing (NGS) analysis. Tumor removal with clear surgical margins is sufficient for complete cure in most cases. Percutaneous transcatheter embolization in wel

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Al'banova, V. I., and M. A. Nefedova. "Acquired bullous epidermolysis: complexity of diagnostics." Vestnik dermatologii i venerologii 93, no. 2 (2017): 64–72. http://dx.doi.org/10.25208/0042-4609-2017-93-2-64-72.

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The article describes the case of acquired bullous epidermolysis in a woman of 45 years old, suffering from a disease from 2.5 years. As a child, she was diagnosed with herpetiform dermatitis on the base of a clinical picture and histological data. After the period of puberty, when in addition to skin blistering a lesion of the oral mucosa, dystrophy and absence of nail plates, contracture of the 2 fingers of the hands arose, the diagnosis was changed to dystrophic congenital bullous epidermolysis, which did not contradict with re-histological examination of the skin. In order to clarify the d

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Klamminger, Gilbert Georg, Laurent Mombaerts, Karoline Klein, et al. "PATH-44. RAMAN SPECTROSCOPY AS A DIAGNOSTIC TOOL IN NEUROPATHOLOGY." Neuro-Oncology 23, Supplement_6 (2021): vi125. http://dx.doi.org/10.1093/neuonc/noab196.496.

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Abstract BACKGROUND Although microscopic assessment is still the diagnostic gold standard in pathology, non-light microscopic methods such as new imaging methods and molecular pathology have considerably contributed to more precise diagnostics. As an upcoming method, Raman spectroscopy (RS) offers a "molecular fingerprint" which could be used to differentiate tissue heterogeneity or diagnostic entities. RS has so far been successfully applied on fresh and frozen tissue, however more aggressively, chemically treated tissue such as formalin-fixed, paraffin-embedded (FFPE) samples are challenging

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Sumedi, I. R., T. I. Shalaeva, A. S. Plekhanova, N. P. Sharova, and T. P. Astakhova. "An approach for determination of proteasome activity in small amounts of thyroid tumor samples." Hirurg (Surgeon), no. 5 (October 22, 2022): 41–46. http://dx.doi.org/10.33920/med-15-2205-05.

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The accuracy of preoperative diagnosis of thyroid tumors is still insufficiently high. Determination of proteasome activity is a promising method for preoperative and/or intraoperative diagnosis of tumors of this localization, however, the method of its implementation involved obtaining a rather large tissue sample, from 20 to 70 mg. Separation of such a fragment from the tumor may complicate further histological examination. In this regard, the aim of this work was to determine the smallest amount of tissue sample suitable for measuring proteasome activity and diagnostics. The obtained result

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Busse, Madleen, Mark Müller, Melanie A. Kimm, et al. "Three-dimensional virtual histology enabled through cytoplasm-specific X-ray stain for microscopic and nanoscopic computed tomography." Proceedings of the National Academy of Sciences 115, no. 10 (2018): 2293–98. http://dx.doi.org/10.1073/pnas.1720862115.

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Many histological methods require staining of the cytoplasm, which provides instrumental details for diagnosis. One major limitation is the production of 2D images obtained by destructive preparation of 3D tissue samples. X-ray absorption micro- and nanocomputed tomography (microCT and nanoCT) allows for a nondestructive investigation of a 3D tissue sample, and thus aids to determine regions of interest for further histological examinations. However, application of microCT and nanoCT to biological samples (e.g., biopsies) is limited by the missing contrast within soft tissue, which is importan

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Prishchepa, Andrey. "Heavy form of placenta disfunction: early diagnostics and tactic of conduct of women." Perinatology and reproductology: from research to practice 4, no. 3-1 (2024): 27–34. https://doi.org/10.52705/2788-6190-2024-03.1-03.

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The objective: to develop the modern method of early diagnostics of heavy forms of placenta disfunction. Materials and methods. Taking into account clinical motion of pregnancy, from 100 women two groups of comparison were formed: I group was made by 50 women with placenta disfunction; II group – 50 women with placenta disfunction in combination with preeclampsia and by extragenital pathology. A control group (III group) was made 30 healthy expectant mothers. In the II group of comparison of preeclampsia diagnosed in 100% supervisions (easy degree – in 88,0% pregnant and middle degree – in 12,

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Rinaldi, Valentina, Laura Nordio, Massimo Vignoli, Stefano Masci, Lorenzo Ressel, and Paolo Emidio Crisi. "Clinical, Histological, and Immunohistochemical Insights into a Canine Hepatic Myofibroblastic Sarcoma." Veterinary Sciences 12, no. 6 (2025): 521. https://doi.org/10.3390/vetsci12060521.

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Hepatic sarcomas are rare and aggressive tumors in veterinary medicine, with limited reports in the literature. This case report describes a canine hepatic myofibroblastic sarcoma in a 5-year-old spayed female Dobermann. The dog presented with abdominal enlargement and was diagnosed with a large hepatic mass following comprehensive diagnostic evaluations, including blood tests, imaging, and histopathology. Histological and immunohistochemical analyses confirmed the tumor’s myofibroblastic origin, characterized by positivity for markers such as vimentin, glial fibrillary acidic protein (GFAP),

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Alempijevic, Tamara, Miodrag Krstic, Ivan Jovanovic, and Dragan Popovic. "A review of current methods in the diagnostics of morphological changes in chronic pancreatitis." Srpski arhiv za celokupno lekarstvo 136, no. 11-12 (2008): 675–79. http://dx.doi.org/10.2298/sarh0812675a.

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Chronic pancreatitis is a disease with well-defined histopathology, however, the diagnosis is not based on the grading of histological changes, but on the features registered by the methods of morphological and functional diagnostic procedures. The correct diagnosis of chronic pancreatitis is easy in advanced stages, but difficult in early stages of the disease. In this review, we present the current methods used (echosonography, computer tomography, magnetic resonance, endoscopic retrograde cholangiopancreatography, endoscopic echosonography) in the diagnostics of chronic pancreatitis.

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Roessner, Albert, Sabine Franke, Julian Schreier, Sarah R. Ullmann, and Franziska S. Karras. "Non-Coding RNAs in Diagnostic Pathology of High-Grade Central Osteosarcoma." Diagnostics 15, no. 11 (2025): 1355. https://doi.org/10.3390/diagnostics15111355.

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A histological evaluation remains the cornerstone of diagnosing highly malignant osteosarcoma, having demonstrated its efficacy and reliability over several decades. However, despite these advancements, misdiagnoses with severe consequences, including inadequate surgical procedures, continue to occur. Consequently, there is a pressing need to further enhance diagnostic security. Adjunct immunohistochemical approaches have demonstrated significant effectiveness in regard to cancer diagnostics, generally. However, their utility for identifying highly malignant osteosarcoma is limited. Molecular

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Kasoyan, K. T., E. G. Kirilenko, I. O. Tinkova, and Y. N. Khionidi. "CYTOLOGICAL DIAGNOSIS OF CHOROIDAL MELANOMA. CLINICAL CASE." Laboratornaya i klinicheskaya meditsina. Farmatsiya, no. 4 (2022): 60–66. http://dx.doi.org/10.14489/lcmp.2022.02.pp.060-066.

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COVID-19 infection can cause various pathological processes in the eyes [1]. Changes in the vascular membrane of the eye can not always be differentiated without mistakes from malignance. The miss-diagnostics of choroidal melanoma can lead to incorrect and aggressive treatment [2]. The clinical report shows the absence of positive dynamics in choroiditis in a patient in the COVID-19 convalescence which allowed the suspicion a tumor. The result of cytological examination indicated a neoplasm of melanocytic in origin which was an indication for enucleation. In the laboratory settings the role of

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Titov, S. E., S. A. Lukyanov, S. V. Sergiyko, et al. "Problems of follicular thyroid carcinoma diagnostics." Head and Neck Tumors (HNT) 13, no. 3 (2023): 10–23. http://dx.doi.org/10.17650/2222-1468-2023-13-3-10-23.

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Introduction. Follicular thyroid cancer is much less common than papillary cancer. Nevertheless, the main difficulties in preoperative diagnosis are associated with this morphological type. A fine needle aspiration biopsy is not able to distinguish a benign follicular adenoma from a follicular carcinoma, which forces surgeons to perform diagnostic resection of the thyroid gland in all patients with a cytological conclusion «follicular tumor».Aim. To search for microRNAs specific to follicular cancer by sequencing a new generation.Materials and methods. The data of patients with a preoperative

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Szőke, János, and Nóra Udvarhelyi. "Modern pathologic diagnostics of breast cancer." Orvosi Hetilap 153, no. 1 (2012): 22–30. http://dx.doi.org/10.1556/oh.2012.29251.

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The diagnosis of breast cancer is morphologically based. Pathologic parameters, such as tumor size, lymph node status, and histological grade are well accepted to guide treatment decisions in clinical practice. Estrogen receptor, progesterone receptor and HER2 status are also routinely assessed in today’s pathology laboratories to provide further information on predictive and prognostic factors affecting patients’ care. Newer molecular techniques, including gene-expression profiling have been widely used to study breast cancer and several molecular prognostic tests already available for clinic

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Chulovskaya, I. G., K. A. Egiazaryan, M. A. Skvortsova, and E. L. Lobachev. "ULTRASOUND DIAGNOSTICS OF SYNOVIAL CYSTS OF THE HAND AND WRIST." Traumatology and Orthopedics of Russia 24, no. 2 (2018): 108–16. http://dx.doi.org/10.21823/2311-2905-2018-24-2-108-116.

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Purpose– to evaluate the efficiency and rationale for a mandatory ultrasound examination of patients with synovial cysts of the hand and wrist joint.Material and methods. The authors performed examination and following treatment of 274 patients with synovial cysts of the hand from 2005 till 2017. The diagnostics was performed basing on clinical and medical history data, roentgenology findings, ultrasonographic data, intraoperative diagnostics and postoperative histological studies. When needed MRT was performed in 35 (12.8%) patients and CT scans in 7 (2.6%) patients. In the presence of clinic

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Nechipay, A. M., M. V. Zobnina, L. M. Cherkasova, I. B. Perfilyev, and V. A. Krivopuskov. "Morphological and endoscopic diagnostic criteria of serrated adenomas of the colon." Russian Journal of Gastroenterology, Hepatology, Coloproctology 26, no. 1 (2016): 107–15. http://dx.doi.org/10.22416/1382-4376-2016-26-1-107-115.

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The aim of review. To generalize literature data on endoscopic and morphological diagnostics of serrated adenomas of the colon. Key points. In 2010 a new variant of histological classification of colonic tumors have been accepted by WHO, according to which serrated neoplasms were defined as separate group of preneoplastic changes, along with colonic adenomas. At the present time hyperplastic polyps and other serrated neoplasms are considered to be precursor lesions for 15 to 20% of sporadic or asymptomatic colorectal cancers located mainly in proximal colon, that progress by specific serrated

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Orlov, Andrei E., Aleksei G. Gabrielyan, Oleg I. Kaganov, Mikhail A. Postnikov, Dmitrii A. Trunin, and Yuliya L. Denisova. "Identification of the site for biopsy in oral mucosa cancer diagnostics." Science and Innovations in Medicine 5, no. 3 (2020): 181–85. http://dx.doi.org/10.35693/2500-1388-2020-5-3-181-185.

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Objective to refine the method of incisional biopsy in the diagnosis of oral mucosa cancer using the auto-fluorescent stomatoscopy. Materials and method.The study was conducted on the base of the Samara Regional Clinical Oncology Center. The inclusion criterion for patients was the diagnose of the oral mucosa cancer of various localization. Patients were divided into 2 groups. The main group included patients (n=43), who were being diagnosed for cancer with the help of optimized incisional biopsy of the oral mucosa formations, using the "AFS-400" autofluorescence complex and glasses with

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Marutani, Akiko, Ryou Nakano, Noriyuki Nishi, and Tomonori Yamada. "Histological Characteristics of Myxoid (Metaplastic) Meningioma in a 44-Year-Old Woman." Case Reports in Oncological Medicine 2019 (December 6, 2019): 1–4. http://dx.doi.org/10.1155/2019/9207632.

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Myxoid (metaplastic) meningioma is the rarest WHO grade 1 meningioma, and its histological characteristics are useful in diagnostics. We present the case report of a myxoid (metaplastic) meningioma in a 44-year-old woman to highlight the important histological features and observations that are critical for making an accurate diagnosis. We report a rare myxoid meningioma using magnetic resonance imaging (MRI) images and its histopathological features.

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