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Journal articles on the topic 'Histological Subtype'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Erber, Ramona, and Arndt Hartmann. "Histology of Luminal Breast Cancer." Breast Care 15, no. 4 (2020): 327–36. http://dx.doi.org/10.1159/000509025.

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Background: Invasive breast cancer (IBC) can be categorized into prognostic and predictive molecular subtypes (including luminal breast cancer) using gene expression profiling. Luminal IBC comprises a variety of histological subtypes with varying clinical and pathological features. Summary: IBC of no special subtype is the most common histological subtype in general and likewise within luminal IBC. Classical invasive lobular breast cancer, typically clustering into luminal subgroup, is characterized by discohesive growth and loss of E-cadherin expression. Infrequent, morphologically distinct l

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S. Afriyie-Mensah, Jane, Ernest Kwarteng, John Tetteh, et al. "A three-year review of lung cancer patient characteristics in a tertiary hospital." Ghana Medical Journal 57, no. 3 (2023): 167–74. http://dx.doi.org/10.4314/gmj.v57i3.2.

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Objective: The study sought to determine clinical characteristics and histologic subtypes of a cohort of lung cancer patients in a tertiary facility.Design: Retrospective review of the medical records of histology-confirmed lung cancer cases at the respiratory clinic over a 3-year period.Setting: Respiratory Clinic, Korle-Bu Teaching Hospital, Accra, GhanaParticipants: All adult patients with histologically diagnosed lung cancer were enrolled.Main outcome measures: Lung cancer histological typesResults: The proportion of lung cancer cases was 12.4%. The majority were women (57.8%) and the mean

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Ferreira, Flavia Regina, Bruna da Costa Pevide, Rafaela Fabri Rodrigues, Luiz Fernando Costa Nascimento, and Marcia Lanzoni de Alvarenga Lira. "Differences in age and topographic distribution of the different histological subtypes of basal cell carcinoma, Taubaté (SP), Brazil." Anais Brasileiros de Dermatologia 88, no. 5 (2013): 726–30. http://dx.doi.org/10.1590/abd1806-4841.20132145.

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BACKGROUND: Basal cell carcinoma is the most common form of cancer in humans. OBJECTIVES: To identify the epidemiology of basal cell carcinoma in Taubaté-SP and verify a possible association between topography and the different histological subtypes of this tumor. METHODS: This was a cross-sectional study conducted at The University Hospital of Taubaté between 01/01/08 and 12/31/09. The study included patients with a confirmed diagnosis of basal cell carcinoma, of both genders, without age restrictions. The variables studied were incidence of basal cell carcinoma, topography, histological subt

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Ioannis, Manolis, Kafiri Georgia, Venetikou Maria, Thalassinos Nikolaos, and Anthouli-Anagnostopoulou Fragkiski. "Prognostic factors of Invasive Ductal Breast Carcinoma Non Special Type (NST). A Study of 98 cases." REVIEW CLINICAL PHARMACOLOGY AND PHARMACOKINETICS, INTERNATIONAL EDITION 37, no. 2 (2023): 53–62. https://doi.org/10.5281/zenodo.8337644.

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<em>Prognostic factors of histological subtypes in breast cancer, is still not well established, guidelines based on the histological subtype alone. The decisions for therapy are guided mostly independently of the histological subtype and are also guided by biomarkers and tumor stage. We analyzed a special histological subtype, Invasive Ductal Breast Carcinoma Non Special Type and correlated with patient’s age, tumor grade, comedo type necrosis, necrosis, ER and PR receptors, Ki67 expression, HER2 status, pT tumor stage, pN lymph nodes stage, TNM classification and clinical tumor stage,

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Leshchyshyn, Ivan M., Leonid Yu Markulan, Olga I. Okhotska, and Pavlo L. Byk. "The impact of colectomy on the quality of life in patients with chronic slow-transit constipation according to the pac-qol scale, depending on the histological subtype of the colonic wall." Polski Merkuriusz Lekarski 53, no. 3 (2025): 367–77. https://doi.org/10.36740/merkur202503111.

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Aim: To assess the quality of life using the PAC-QOL scale in patients with chronic slow-transit constipation depending on the histological subtypes of the colonic wall after colectomy. Materials and Methods: The dynamics of quality-of-life scores were studied in 107 patients with slow-transit constipation resistant to conservative treatment after colectomy using PAC-QOL questionnaire. Results: Significant improvement in quality of life was observed for all PAC-QOL subscales one year after surgery: physical discomfort improved by 58.7% to 67.7%, psychological discomfort – by 50.5%-67.2%, worri

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Han, Yuchen, Chan Xiang, Haohua Teng, et al. "Comprehensive investigation of mutational features of various lung adenocarcinoma histological subtypes among Chinese patients." Journal of Clinical Oncology 38, no. 15_suppl (2020): e21090-e21090. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e21090.

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e21090 Background: Lung adenocarcinoma (LUAD) is further classified into several histological subtypes according to the World Health Organization classification; however, data on the molecular profile of these histological subtypes are limited. In this study, we aimed to investigate the mutational features of various LUAD histological subtypes among Chinese patients. Methods: We retrospectively analyzed clinical, histopathologic, and sequencing data from 3,425 consecutive patients diagnosed with stage IA-IVB LUAD between January 2017 to December 2019 at the Department of Pathology. Results: Ba

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Srebnijs, Andrejs, Sergejs Isajevs, Jānis Eglītis, Viesturs Krūmiņš, Juris Bērziņš, and Uldis Vikmanis. "Distribution And Clinicopathological Features Of Breast Cancer Histological Subtypes In Latvia." Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 69, no. 1-2 (2015): 14–19. http://dx.doi.org/10.1515/prolas-2015-0001.

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Abstract Breast cancer is a heterogenous disease. It consists of several histological subtypes that can be separated by morphology and immunohistochemistry. The aim of our study was to determine the distribution of breast cancer histological and molecular subtypes, and their relationship with clinical and pathological characteristics. A total of 561 patients who underwent breast carcinoma surgical treatment from January 2003 till December 2012 were enrolled in the study. In total, invasive ductal carcinomas not otherwise specified (IDC-NOS) plus invasive ductal carcinomas no special type (IDC-

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Leschyshyn, I. M., L. Y. Markulan, O. I. Okhotska, P. L. Byk, and R. V. Gonza. "Clinical and anamnestic characteristics of patients with different subtypes of chronic slow transit constipation." General Surgery, no. 1 (May 15, 2025): 42–49. https://doi.org/10.30978/gs-2025-1-42.

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In recent years, chronic slow transit constipation (СSTC) continued to be an actual clinical challenge due to its high prevalence, multifactorial pathogenesis, and the limited efficacy of current therapeutic strategies. The literature still lacks clear evidence regarding the correlation between the clinical manifestations of CSTC and specific histological alterations within the intestinal wall. Objective – to identify the clinical course in peculiarities in patients with CSTC depending on the histological subtype of the colonic wall. Materials and methods. The study included 107 patients diagn

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Valouev, Anton, Wei Tian, Kunwar Singh, et al. "Abstract 1142: Non-invasive cell free DNA (cfDNA) methylation profiling for accurate proportional quantification of lung cancer subtypes." Cancer Research 85, no. 8_Supplement_1 (2025): 1142. https://doi.org/10.1158/1538-7445.am2025-1142.

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Abstract Background: Neoplastic progression in lung cancer often involves tumors with heterogeneous histologies, harboring multiple subclones of distinct histological subtypes - such as lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LSCC), and small cell lung carcinoma (SCLC) - within a single tumor. Determining histological subtype of the tumor typically requires invasive lung tissue biopsy, which precludes serial monitoring both during and after therapy. Treatment regimens targeting the predominant histology may inadvertently select for drug-resistant subclones of alternative subt

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Sugiyama, Eri, Koichi Goto, Genichiro Ishii, et al. "Does EGFR mutation define the histological predominant subtype of lung adenocarcinoma?" Journal of Clinical Oncology 31, no. 15_suppl (2013): 7557. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.7557.

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7557 Background: In 2011, invasive adenocarcinomas were newly classified into the five predominant subtypes by IASLC/ATS/ERS: lepidic, papillary, acinar, micropapillary, and solid. The purpose of this study is to investigate the correlation between EGFRmutation and the histological predominant subtype of lung adenocarcinoma. Methods: Among a total of 1,736 patients with lung adenocarcinoma who underwent surgical resection from 2002 to 2011 in National Cancer Center Hospital East, 1,507 were classified into invasive adenocarcinoma. 526 of whom were examined EGFR mutation status. Histological pr

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Efanov, M. G., N. S. Karnaukhov, N. N. Britskaia, et al. "Intrahepatic cholangiocarcinoma: correlation between histological subtype and survival." Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery 30, no. 1 (2025): 31–38. https://doi.org/10.16931/1995-5464.2025-1-31-38.

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Aim. To study the pathological histological subtypes of intrahepatic cholangiocarcinoma and their impact on survival.Materials and methods. The study involved the analysis of perioperative data from 65 patients with intrahepatic cholangiocarcinoma. Among them, 32 patients (49%) were found to have the small bile duct subtype, while 33 patients (51%) were diagnosed with the large bile duct subtype.Results. The histopathological subtype of intrahepatic cholangiocarcinoma originating from large bile ducts is considered to be a significant factor affecting overall survival (p < 0.0001) and disea

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Mariean, Claudia Raluca, Oana Mirela Tiuca, Alexandru Mariean, and Ovidiu Simion Cotoi. "Variation in CBC-Derived Inflammatory Biomarkers Across Histologic Subtypes of Lung Cancer: Can Histology Guide Clinical Management?" Diagnostics 15, no. 11 (2025): 1437. https://doi.org/10.3390/diagnostics15111437.

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Background/Objectives: The early detection of high levels of CBC-derived inflammatory biomarkers and cellular lines, as well as their variations across different histological subtypes of lung cancer, may aid in the early identification of high-risk lung cancer patients and further guide their clinical approach. Methods: A retrospective descriptive study was conducted and included 202 patients diagnosed with lung carcinoma at the Clinical County Hospital Mureș. The main analyzed parameters were the histological subtype and the stage of the tumor at diagnosis, white blood cell counts, and platel

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Devadass, Clement Wilfred, Angel Beula Royal, Prachi Saxena, Darshitha Devraj, and Mangala Gouri. "Breast Carcinoma: Correlation of Molecular Subtypes with Histopathologic Characteristics." Journal of Medical Sciences and Health 9, no. 3 (2023): 281–87. http://dx.doi.org/10.46347/jmsh.v9i3.23.103.

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Context: Breast carcinoma is a heterogenous disease and similar histological subtypes may exhibit different behavior and treatment response. The molecular classification may provide better prognostic, predictive and therapeutic information than histological classification. The study aimed at evaluating the distribution of molecular subtypes of breast cancer and its association with prognostic factors. Method: This prospective cross-sectional study was conducted on breast cancer cases, over a period of 2 years, at M.S. Ramaiah Medical College and Hospitals, Bengaluru. The resection specimens we

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Roetzer-Pejrimovsky, Thomas, Barbara Kiesel, Karl-Heinz Nenning, et al. "EPCO-15. LINKING HISTOLOGICAL GLIOBLASTOMA PHENOTYPES TO TRANSCRIPTIONAL SUBTYPES AND PROGNOSIS USING DEEP LEARNING." Neuro-Oncology 24, Supplement_7 (2022): vii118—vii119. http://dx.doi.org/10.1093/neuonc/noac209.450.

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Abstract Deep learning is increasingly utilized in medical image analysis and shows promise to substantially inform treatment decisions in clinical practice. While it finds broad applications in radiology or genomics, there are still relatively few applications of deep learning to the analysis of histological images. A disease in which a better understanding of underlying phenotype-genotype correlations seems crucial is glioblastoma, the most common malignant brain tumor in adults that features a dismal prognosis and limited therapeutic options. Using a large cohort of 276 glioblastoma patient

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Van Gelder, T., RA Damhuis, and HC Hoogsteden. "Prognostic factors and survival in malignant pleural mesothelioma." European Respiratory Journal 7, no. 6 (1994): 1035–38. http://dx.doi.org/10.1183/09031936.94.07061035.

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Malignant pleural mesothelioma is a lethal disease and little is known about prognostic factors. The prognostic significance of age, stage of disease, gender and histological subtype was studied in 167 new cases of cytologically (15%) or histologically (85%) proven malignant pleural mesothelioma in the Rotterdam area, during the period 1987-1989. Median survival of all patients was 242 days. Univariate analysis identified age, stage and histopathological subtype as significant prognostic factors, which was confirmed in multivariate analysis. Median survival rates for patients < 65, 65-74 an

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Harrison, L., T. McCulloch, and N. Beasley. "Soft tissue head and neck sarcoma: experience of a tertiary referral centre over a 15-year period." Journal of Laryngology & Otology 133, no. 12 (2019): 1053–58. http://dx.doi.org/10.1017/s0022215119002299.

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AbstractBackgroundHead and neck soft tissue sarcoma is uncommon. It is both histologically and clinically heterogeneous, ranging from an indolent, locally destructive tumour, to a locally aggressive neoplasm with metastatic potential.MethodsA retrospective review was conducted of all adult head and neck soft tissue sarcomas, including cases of malignant soft tissue sarcoma and all intermediate type tumours, diagnosed between 1997 and 2012.ResultsSixty-eight cases were identified in this series from the sarcoma multidisciplinary team. Seventeen different histological subtypes of sarcoma were id

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Tang, Phua Hwee, Sharon Low, Enrica Tan, and Kenneth Chang. "IMG-01. DWI RATIO OF HISTOLOGICAL MOLECULAR SUBTYPES OF PAEDIATRIC MEDULLOBLASTOMAS." Neuro-Oncology 22, Supplement_3 (2020): iii354. http://dx.doi.org/10.1093/neuonc/noaa222.337.

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Abstract AIM To evaluate if diffusion weighted imaging (DWI) ratio on MRI is able to distinguish between the histological molecular subtypes of paediatric medulloblastomas. MATERIALS AND METHODS From 2002 to 2017, 38 cases of medulloblastoma with preoperative MRI available had histological subtyping performed with NanoString nCounter technology. The medulloblastomas were classified into 4 subtypes. There were 3 Sonic Hedgehog (SHH), 9 Wingless (WNT), 12 Group 3 and 14 Group 4 subtypes. Single operator manually outlined solid non-haemorrhagic component of the tumour on DWI images with largest a

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Rampazzo, Alexandre, Guilherme Lang Mott, Kalil Fontana, and Renato B. Fagundes. "Gastric adenocarcinoma trends in the central region of Rio Grande do Sul (Southern Brazil): what has changed in 25 years?" Arquivos de Gastroenterologia 49, no. 3 (2012): 178–83. http://dx.doi.org/10.1590/s0004-28032012000300002.

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CONTEXT: Gastric cancer is the fourth most common malignancy in the world. Its incidence varies greatly by geographic region. The highest rate is in Eastern Asia, mainly in Japan and China. In Brazil, gastric cancer is the third most common cancer in males and the fifth most common cancer in females. Rio Grande do Sul state, in Southern Brazil, has similar figures. The main histological type of gastric cancer is adenocarcinoma. OBJECTIVE: To assess the trends of this cancer over 25 years in a reference center in central Rio Grande do Sul. METHODS: We reviewed the records of upper gastrointesti

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Radhakrishnan, Sourabh, Sreeja Raju, Jamuna Angel Joy, and Sanjana Ramakrishnan. "Histopathological subtypes of lung cancer presented at a tertiary care cancer hospital in Kerala: a cross sectional study." International Journal of Advances in Medicine 8, no. 1 (2020): 11. http://dx.doi.org/10.18203/2349-3933.ijam20205402.

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Background: Lung cancer is one of the commonest cancers causes high rate of mortality worldwide. An increasing incidence of lung cancer and the pathological profile varies among gender and geographical regions. The present study was aimed to assess the pattern of histological subtypes of lung cancer and their distribution with age and gender.Methods: Histologically proven primary lung cancers were selected from the cancer registry. Distribution of subtypes of lung cancer in various age and gender was collected. The major clinical presentation among the non-small cell lung carcinoma (NSCLC) and

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Siskou, Styliani, Paola Pasquali, and Myrto Trakatelli. "High Frequency Ultrasound of Basal Cell Carcinomas: Ultrasonographic Features and Histological Subtypes, a Retrospective Study of 100 Tumors." Journal of Clinical Medicine 12, no. 12 (2023): 3893. http://dx.doi.org/10.3390/jcm12123893.

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(1) Background: 22 MHz high frequency ultrasound (HFUS) is a non-invasive imaging technique that gives information on depth, length, volume and shape of skin tumors. (2) Methods: We reviewed the clinical, ultrasound, and histological records of 54 patients with 100 histologically confirmed basal cell carcinoma (BCC) tumors with the use of HFUS. (3) Results: Most infiltrative tumors (n = 16/21, 76.2%) were irregular shaped, followed by five (23.8%) being round shaped; most superficial tumors (n = 25/29, 86.2%) were ribbon shaped, followed by four (13.8%) being round shaped; most nodular tumors

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Goyal, Namisha, Prita Pradhan, Ranjana Giri, and Subrat Kumar Sahoo. "Histomolecular subtyping of periampullary adenocarcinoma and its correlation with pathological prognostic factors." Journal of Integrative Medicine and Research 2, no. 3 (2024): 143–48. http://dx.doi.org/10.4103/jimr.jimr_27_24.

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Abstract Introduction: Periampullary adenocarcinoma (PAC) is a less frequent tumor accounting for approximately 0.5%–2% of all gastrointestinal malignancies. Histologically, PAC subtyped into intestinal and pancreaticobiliary adenocarcinoma which is further confirmed by immunohistochemistry (IHC). Subtyping of PAC has emerged as an important prognostic factor with potential therapeutic implications. Aim: The aim of the study was to assess morphology and IHC expression of CK7, CK20, and CDX2 to subtype PAC and correlate the subtype predicted on histomorphology with the immunohistochemical expre

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Olazo Cárdenas, Kamyla Mychele, Juan Carlos Zea Burga, Gabriel De La Cruz Ku, and Ramiro Fernández. "Gallbladder cancer at a tertiary referral hospital in Peru: characteristics and outcomes in 20 years’ experience." ACTA MEDICA PERUANA 42, no. 2 (2025): 100–110. https://doi.org/10.35663/amp.2025.422.3259.

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Objective: Gallbladder cancer is a relatively uncommon neoplasm of the biliary system, characterized by a notably high mortality rate. Thisstudy aimed to identify prognostic factors for overall survival (OS) in Peruvian patients undergoing surgery for gallbladder cancer. Materials and methods: We conducted a retrospective cohortstudy of patientswith gallbladder carcinoma who underwent surgery at the Instituto Nacional de Enfermedades Neoplásicas between 2000 and 2020. OS was analyzed using the Kaplan–Meier method, and prognostic factors were identified using Cox proportional hazardsregressionm

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Han, Yiqun, Ahmed Shah, Yuan Yao, Robert W. Mutter, and Meng Xu-Welliver. "Clinical Differences Among Histological Categories of Sarcoma: Insights from 97,062 Patients." Cancers 17, no. 10 (2025): 1706. https://doi.org/10.3390/cancers17101706.

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Objectives: To evaluate the clinical heterogeneity of sarcomas by examining associations between histological subtypes, metastatic patterns, treatment modalities, and survival outcomes. Methods: We analyzed data from 97,062 adult patients diagnosed with sarcoma between 2000 and 2020, using the Surveillance, Epidemiology, and End Results (SEER) database. Fourteen histological subtypes were included. Propensity score matching (PSM) was employed to adjust for baseline differences, and Cox proportional hazards models were used to identify prognostic variables. Results: The most prevalent subtypes

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Mansoor, Nafisa Awadh. "The patterns and age distribution of breast cancer in South Yemen." University of Aden Journal of Natural and Applied Sciences 21, no. 2 (2017): 357–62. http://dx.doi.org/10.47372/uajnas.2017.n2.a14.

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Breast cancer is the most common malignancy type diagnosed in women in developed countries and the second most common type diagnosed in developing countries. The aim of this study is to determine the pattern of breast cancer, to correlate the age distribution with the histological subtypes, and to compare our study with other geographic regions. It is a retrospective study, the data were collected from the records of the cancer Registration Center including 489 breast cancer patients during 10 years from(2002-2011). The most common subtype of breast cancer was invasive ductal carcinoma (88.1%)

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Gotoh, Osamu, Norio Tanaka, Tomoko Kaneyasu, Seiichi Mori, and Tetsuo Noda. "Abstract 6606: Genomic features of histological and molecular subtypes in Japanese ovarian cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 6606. https://doi.org/10.1158/1538-7445.am2025-6606.

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Abstract Ovarian cancer is an intractable disease and comprises a number of histological subtypes that are associated with clinical characteristics such as therapeutic efficacy and likelihood of relapse. Since ovarian cancer exhibits heterogeneity even within a same histological subtype, it is critical to develop a complementary classification framework, in which clinicopathological and biological features are associated with each subtype. Previously, for endometrial cancer, a molecular subtyping scheme based on genomic features was developed by The Cancer Genome Atlas (TCGA) and the scheme ha

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Mboungou Malanda, Dimitry Moudiongui, Anicet Luc Magloire Boumba, and Gervillien Arnold Malonga. "Breast Cancer in Women: Epidemiological, Histological, Immunohistochemical and Molecular Sub-Types in the Republic of Congo." International Journal of Health Sciences and Research 11, no. 5 (2021): 103–16. http://dx.doi.org/10.52403/ijhsr.20210515.

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Introduction: Breast cancer is a heterogeneous disease with a variety of morphological, molecular, treatment response and clinical outcome characteristics. The objective of this work was to assess the epidemiological, histological, immunohistochemical and molecular subtypes of breast cancer in women in the Republic of Congo. Material and Methods: We carried out a cross-sectional descriptive study which took place from January 1, 2014 to December 31, 2020. The study focused on 150 cases of breast cancer in patients diagnosed at the University Hospital of Brazzaville (CHU-B). The epidemiological

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Blay, Jean-Yves. "Treatment of advanced soft tissue sarcoma by histological subtype: wish, prediction or reality?" Future Oncology 15, no. 26s (2019): 5–10. http://dx.doi.org/10.2217/fon-2019-0488.

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Soft tissue sarcomas (STS) are heterogenous cancers encompassing more than 100 histological and molecular subtypes. Their extreme rarity underscores the need for international collaboration to identify specific treatment protocols. Increasing knowledge of STS complexity as defined by molecular biology has led to the introduction of targeted therapies for several sarcoma subtypes, which is an encouraging start. In advanced STS, doxorubicin-based regimens are standard first-line chemotherapy. Options for second and later lines include ifosfamide, trabectedin, pazopanib, eribulin and gemcitabine-

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Mørk, Erik, Patricia Mjønes, Olav A. Foss, et al. "Clinical versus Histological Assessment of Basal Cell Carcinoma Subtype and Thickness of Tumours Selected for Photodynamic Therapy." Acta Dermato-Venereologica 104 (May 15, 2024): adv18308. http://dx.doi.org/10.2340/actadv.v104.18308.

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Photodynamic therapy is an approved treatment for primary, superficial, and small nodular basal cell carcinomas with a thickness of < 2 mm located on low-risk sites. Histologically verified basal cell carcinomas clinically assessed as suited for photodynamic therapy were included. The study aimed to investigate the agreement between clinical and histological assessments of basal cell carcinoma subtypes and thickness of tumours selected for photodynamic therapy with histopathological evaluation as a reference. A total of 343 tumours were included. The agreement between clinical and histologi

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Adekunle AA, Idowu NA, Rasheed MW, Aderibigbe OA, and Olatide OO. "Chromophobe: A rare histological variant of renal cell carcinoma." Ibom Medical Journal 16, no. 3 (2023): 355–58. http://dx.doi.org/10.61386/imj.v16i3.338.

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Background: Renal cell carcinoma (RCC) is an adenocarcima of the kidney. It is a highly heterogeneous disease with sixteen known subtypes out of which five predominate. The most common subtype is clear cell RCC which accounts for 75-85%. The chromophobe subtype of RCC is rarely seen. It is reported to constitute 4-5% of RCC subtype. This study was aimed at reporting the first case of chromophobe renal cell carcinoma in our community a rare histological subtype of RCC which was discovered incidentally. Our objective was to describe the clinical, histological and immunohistochemical evaluation o

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Mlynska, Agata, Jolita Gibavičienė, Otilija Kutanovaitė, et al. "Defining Melanoma Immune Biomarkers—Desert, Excluded, and Inflamed Subtypes—Using a Gene Expression Classifier Reflecting Intratumoral Immune Response and Stromal Patterns." Biomolecules 14, no. 2 (2024): 171. http://dx.doi.org/10.3390/biom14020171.

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The spatial distribution of tumor infiltrating lymphocytes (TILs) defines several histologically and clinically distinct immune subtypes—desert (no TILs), excluded (TILs in stroma), and inflamed (TILs in tumor parenchyma). To date, robust classification of immune subtypes still requires deeper experimental evidence across various cancer types. Here, we aimed to investigate, define, and validate the immune subtypes in melanoma by coupling transcriptional and histological assessments of the lymphocyte distribution in tumor parenchyma and stroma. We used the transcriptomic data from The Cancer Ge

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Shubbar, Yassir Alaa Muhammed Hassan. "CORRELATION BETWEEN DIFFERENT CLINICOPATHOLOGICAL PARAMETERS AND MOLECULAR SUBTYPES OF FEMALE BREAST CARCINOMA IN SOUTH REGION OF IRAQ." Wiadomości Lekarskie 76, no. 1 (2023): 97–107. http://dx.doi.org/10.36740/wlek202301114.

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The aim: To correlate variable clincopathological parameters with molecular subtypes of the breast carcinoma, which affect the prognosis and management of breast malignancy. Materials and methods: In this study a total of 511 female patients with breast carcinoma were included, ranging from 32 to 85 years of age, with 35.8% premenopausal and 64.1% being post-menopausal. The sample slides were stained immunohistochemically for estrogen receptors (ER), progesterone receptors (PR), ki67 and HER2, the tumors were graded histologically using the Nottingham criteria system. Results: Most tumors (72.

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Ilić, Ivan, Jana Cvetković, Ratko Ilić, et al. "Differences in Histological Subtypes of Invasive Lobular Breast Carcinoma According to Immunohistochemical Molecular Classification." Diagnostics 14, no. 6 (2024): 660. http://dx.doi.org/10.3390/diagnostics14060660.

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The technical complexity of gene expression profiling in routine practice has necessitated the use of surrogate molecular classification of breast cancer, based on immunohistochemical analyses. Background and objectives: The aim of this study was to compare the differences between histological and molecular subtypes of invasive lobular carcinoma (ILC) of the breast, in order to be able to predict the behavior and prognosis of the disease, as well as to effectively determine therapy. Material and Methods: This study included 263 cases of breast ILC diagnosed over a seven-year period. The diagno

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Zullo, Lodovica, Mathilde Bateson, Jose Carlos Benitez-Montanez, et al. "Pathomics-based prediction of thymic epithelial tumor subtypes within the French RYTHMIC network." Journal of Clinical Oncology 43, no. 16_suppl (2025): 8112. https://doi.org/10.1200/jco.2025.43.16_suppl.8112.

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8112 Background: Thymic epithelial tumors (TETs) are classified into primary subtypes (A, AB, B1, B2, B3, C) and mixed classes, determined by varying proportions of tumoral and non-tumoral components, and different subtypes have different prognosis. This heterogeneity, combined with their rarity, poses significant diagnostic challenges that impact tumor treatment. We aim to develop and test a multiple-instance learning (MIL) model capable of classifying TETs major histological subtypes from hematoxylin-eosin/hematoxylin-eosin-saffron (HE/HES)-stained slides. Methods: Cases who underwent centra

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Tsuda, H. "Histological Significance of Intrinsic Subtype Classification." Annals of Oncology 23 (October 2012): xi59. http://dx.doi.org/10.1093/annonc/mds567.

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ÇOBAN, Elif, Berkan ALTAY, and Mehmet Hüseyin METİNEREN. "Oral Fibrolipoma: A Rare Histological Subtype." Turkiye Klinikleri Journal of Case Reports 30, no. 4 (2022): 223–25. http://dx.doi.org/10.5336/caserep.2022-88264.

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Anzillotti, Giuseppe, Francesca Vespasiano, Chiara Maria Scandavini, et al. "Histological Subtypes Might Help Risk Stratification in Different Morphological Types of IPMNs: Back to the Future?" Journal of Clinical Medicine 13, no. 22 (2024): 6759. http://dx.doi.org/10.3390/jcm13226759.

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Background: Intraductal papillary mucinous neoplasms (IPMNs) display four histological subtypes: gastric foveolar, pancreaticobiliary, intestinal, and oncocytic. All of these subtypes harbor a different risk of cancer development. The clinical impact of these subtypes concerning the occurrence of high-grade dysplasia (HGD)/cancer (C) in specific morphological types, such as branch-duct (BD), main-duct (MD), and mixed-type (MT) IPMNs, has been less investigated. Hence, our aim was to investigate the prevalence of histological subtypes and their possible association with HGD/C concerning morphol

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Ng, Sam, Sonia Zouaoui, Faiza Bessaoud, et al. "An epidemiology report for primary central nervous system tumors in adolescents and young adults: a nationwide population-based study in France, 2008–2013." Neuro-Oncology 22, no. 6 (2019): 851–63. http://dx.doi.org/10.1093/neuonc/noz227.

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Abstract Background Primary central nervous system tumors (PCNST) among adolescents and young adults (AYA, 15–39 y) have rarely been reported. We present a nationwide report of PCNST histologically confirmed in the French AYA population between 2008 and 2013. Methods Patients were identified through the French Brain Tumor Database (FBTDB), a national dataset that includes prospectively all histologically confirmed cases of PCNST in France. Patients aged 15 to 39 years with histologically confirmed PCNST diagnosed between 2008 and 2013 were included. For each of the 143 histological subtypes of

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Movchan, O. V., I. Yu Bagmut, and I. V. Dosenko. "Risk factors of local relapses in patients with breast cancer depending on the properties of the primary tumor." PROBLEMS OF UNINTERRUPTED MEDICAL TRAINING AND SCIENCE 43, no. 3-4 (2021): 67–73. http://dx.doi.org/10.31071/promedosvity2021.03-04.067.

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Of all a spread of disorders after mastectomy, most frequently we expect about the event of local relapse. The aim – to research the frequency of local relapses in patients with breast carcinoma, considering the subtype properties of the primary tumor. Materials. 6136 patients with breast carcinoma, including 146 patients with LR – main group, and 455 patients without LR – control group. They distributed betting on age, the state of the menstrual function, stage of the disease, histological type of cancer, grade, tumor subtype. Results. In step with the histological structure, ductal carcinoma

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Takei, Hidehiro, Yummy Nguyen, Vidya Mehta, Murali Chintagumpala, Robert C. Dauser, and Adekunle M. Adesina. "Low-level copy gain versus amplification of myc oncogenes in medulloblastoma: utility in predicting prognosis and survival." Journal of Neurosurgery: Pediatrics 3, no. 1 (2009): 61–65. http://dx.doi.org/10.3171/2008.10.peds08105.

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Object Medulloblastoma (MB) is a malignant embryonal tumor of the cerebellum. Amplification of c-myc or N-myc is infrequently identified and, when present, is often associated with the large cell/anaplastic (LC/A) phenotype. The frequency of low-level copy gain of myc oncogenes and its relationship to prognosis of MB has not been explored. Methods Archival cases of MB were histologically reviewed and classified into 3 major subtypes: classic, nodular, and LC/A. Using quantitative real-time polymerase chain reaction (PCR), the authors analyzed 58 cases with a pure histological subtype for the c

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Roseweir, Antonia K., James Hugh Park, Sanne ten Hoorn, et al. "Prognostic phenotypic subtypes to predict recurrence and response to adjuvant chemotherapy for colorectal cancer." Journal of Clinical Oncology 38, no. 4_suppl (2020): 205. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.205.

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205 Background: Histological phenotypic subtypes have been proposed that stratify survival in a discovery cohort of patients with stage I-III colorectal cancer (CRC). However, clinical utility has not been validated nor associations with recurrence and chemotherapy assessed. Therefore, this study assessed prognostic value in patients with stage I-III CRC as well as predictive value for recurrence and chemotherapy response. Methods: Two independent stage I-III CRC patient cohorts were utilized to assess associations between phenotypic subtypes, survival, and recurrence. Stage II-III patients, f

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Chawsheen, Mahmoud A., Ahmed A. Al-Naqshbandi, Rivan H. Ishaac, and Fairuz A. Kaka Sur. "Epidemiological Trends and Molecular Characterization of Breast Carcinoma in Erbil, Kurdistan Region of Iraq." ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY 13, no. 1 (2025): 86–93. https://doi.org/10.14500/aro.11860.

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Accumulated evidence suggests a tangible increase in breast cancer (BC) patients in the Kurdistan region of Iraq, yet data on their histological and molecular subtypes remain limited. This study aims to assess the prevalence, histopathologic features, and molecular profiles of BC incidences in Erbil. For this purpose, 261 clinical records of histologically confirmed BC cases from Rizgary Teaching Hospital are analyzed. Results reveal that invasive ductal carcinoma (IDC) emerged as the most frequent histological subtype. In terms of hormonal receptor status, mastectomy patients who tested posit

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Sahrish, Fariha. "Histological Subtypes & Staging of Post-Chemotherapy Wilms Tumor According to SIOP 2001 Protocol: Study at the Children’s Hospital, Lahore." Proceedings of Shaikh Zayed Medical Complex Lahore 35, no. 3 (2021): 1–5. http://dx.doi.org/10.47489/pszmc-800-35-3-1-5.

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Introduction: Pediatric renal tumors constitute 7 to 8% of pediatric solid malignancies and most common is Wilms tumor. It usually presents as unilateral mass with sporadic and familial associations. It is currently treated by NWTS and SIOP protocols worldwide. In our hospital setup we follow SIOP 2001 protocol to subcategorize different histological subtypes and staging of Wilms tumor after completing four cycles of chemotherapy. Aims & Objectives: To determine the frequency of histological subtypes of Wilms tumor (WT) in post chemotherapy nephrectomy specimens Place and duration of study

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Ravindran, Hiran Kattilaparambil. "Papillary Carcinoma Thyroid – Histological Subtypes and Clinical Significance." Journal of Head & Neck Physicians and Surgeons 10, no. 1 (2022): 30–35. http://dx.doi.org/10.4103/jhnps.jhnps_32_22.

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Papillary carcinoma thyroid is a very common malignancy of the thyroid having a very good overall prognosis. Among the subtypes of this tumor certain histological subtypes identified are more aggressive than the ones with classic histology. The purpose of this review is to stratify the prognosis concerning papillary thyroid carcinoma patients with different histopathological patterns, their features of identification, and molecular differences. This is a narrative review of various published articles including meta-analysis results. This does not contain any studies with human participants by

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Park, Hyung Kyu. "The Metastasis Pattern of Renal Cell Carcinoma Is Influenced by Histologic Subtype, Grade, and Sarcomatoid Differentiation." Medicina 59, no. 10 (2023): 1845. http://dx.doi.org/10.3390/medicina59101845.

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Background and Objectives: Metastasis is a major cause of death in renal cell carcinoma (RCC) patients; therefore, a better understanding of the metastatic process and the ability to predict metastasis in advance is important for treating patients with RCC. This study aimed to investigate whether histological subtypes of RCC and other factors, such as nuclear grade and sarcomatoid differentiation, could predict the probability and location of metastases in patients with RCC. Materials and Methods: Cases of clear-cell, papillary, chromophobe, and sarcomatoid RCC were retrieved and analyzed from

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Ajani, Mustapha Akanji, Ayodeji Akeem Salami, Olutosin Alaba Awolude, and Abideen Olayiwola Oluwasola. "Pattern of triple negative epithelial ovarian cancer in indigenous African women." F1000Research 5 (September 28, 2016): 2415. http://dx.doi.org/10.12688/f1000research.9632.1.

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Background: Triple negative epithelial ovarian cancer (TNEOC) refers to ovarian carcinomas that do not express estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor- type 2 (HER-2/neu). The aim of this study is to determine the pattern of triple negative epithelial ovarian cancer in indigenous African women. Methods: We performed a retrospective review of ER, PR and HER-2/neu expression in 90 Nigerian patients with histologically diagnosed epithelial ovarian cancer. Lack of expression of ER, PR and HER2/neu antigens was used to determine carcinomas that

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Kwon, Whi-An, Ho Kyung Seo, Geehyun Song, Min-Kyung Lee, and Weon Seo Park. "Advances in Therapy for Urothelial and Non-Urothelial Subtype Histologies of Advanced Bladder Cancer: From Etiology to Current Development." Biomedicines 13, no. 1 (2025): 86. https://doi.org/10.3390/biomedicines13010086.

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Urothelial carcinoma (UC) is the most common histological subtype of bladder tumors; however, bladder cancer represents a heterogeneous group of diseases with at least 40 distinct histological subtypes. Among these, the 2022 World Health Organization classification of urinary tract tumors identifies a range of less common subtypes of invasive UC, formerly known as variants, which are considered high-grade tumors, including squamous cell, small-cell, sarcomatoid urothelial, micropapillary, plasmacytoid, and urachal carcinomas, and adenocarcinoma. Their accurate histological diagnosis is critica

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Ajisebutu, Andrew, Jeffrey A. Zuccato, Vikas Patil, Julio Sosa, and Gelareh Zadeh. "CORRELATION OF CLINICAL FEATURES TO DNA METHYLATION-BASED PROGNOSTIC SUBTYPES IN CHORODOMA PATIENTS." Neuro-Oncology Advances 5, Supplement_2 (2023): i9. http://dx.doi.org/10.1093/noajnl/vdad071.036.

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Abstract Chordomas are rare aggressive primary bone cancers affecting the skull-base and spine. We have previously identified robust DNA methylation-based prognostic groups, immune infiltrated and cellular subtypes. Here we further characterize these prognostic subtypes with an extensively annotated clinical database to identify factors that correlate with subtype, and investigate methylation patterns between existing clinical scoring systems groups. METHODS: 68 patients from a multi-institutional 20-year series were identified. These patients’ tumor samples had undergone whole genome DNA meth

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Waterfield Price, Noah, Sam Janes, Fergus Gleeson, Pierre P. Massion, and Jonathan Lehman. "Prediction of adenocarcinoma among other subtypes of lung cancer from CT using deep learning." Journal of Clinical Oncology 39, no. 15_suppl (2021): 3057. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.3057.

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3057 Background: Determination of histological subtype is a crucial step in the management of patients with lung cancer as it informs prognosis and management. The identification of adenocarcinoma (AC) is particularly important with new targeted treatments becoming available. Although the gold standard for diagnosing histological subtype is pathological analysis of tissue samples, interventions can present a risk of complication. Imaging-based, computational approaches to distinguishing malignant from benign lesions have shown promising results. A similar approach may also be applied to determ

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Bjazevic, Jennifer, Jasmir G. Nayak, Premal Patel, et al. "The impact of renal cell carcinoma histopathological subtype on disease prognosis: A Canadian multi-institutional analysis." Journal of Clinical Oncology 33, no. 7_suppl (2015): 480. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.480.

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480 Background: Renal cell carcinoma (RCC) is divided into several histopathological subtypes, each with significantly different clinical features. However, current data regarding the prognostic value of histological subtype is limited and conflicted. We examined the impact of RCC histology on disease prognosis in a large, multi-institutional Canadian analysis. Methods: The Canadian Kidney Cancer Information System (CKCis), a prospective database from 14 Canadian institutions, was utilized for the study. 1284 patients with non-metastatic RCC, who underwent surgical intervention with curative i

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Ha, Gavin. "Abstract IA026: Methods for tumor subtype classification using cell-free DNA." Clinical Cancer Research 30, no. 21_Supplement (2024): IA026. http://dx.doi.org/10.1158/1557-3265.liqbiop24-ia026.

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Abstract Accurately diagnosing the tumor histological subtype is crucial for clinical care. Changes in subtype can emerge during treatment resistance. However, obtaining a biopsy to determine the tumor histology presents challenges for patients with advanced cancers. Circulating tumor DNA (ctDNA) is a non-invasive 'liquid biopsy' solution that overcomes this limitation of tissue accessibility. Current ctDNA approaches primarily focuses on detecting genetic mutations, but these alterations alone may not fully delineate tumor histological subtypes or explain treatment resistance. Recent advancem

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