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Dissertations / Theses on the topic 'Histology of a thymus'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

North, J. "The effects of soluble factors on thymocyte differentiation in the foetal mouse thymus." Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375161.

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2

Arnall, Jane Catherine. "Characterization of alloimmune responses and the generation of transplantation tolerance in thymectomized, thymus-implanted xenopus." Thesis, Durham University, 1987. http://etheses.dur.ac.uk/7066/.

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This Thesis investigates the role of the Xenopus thymus in educating T cells to destroy minor histocompatibility (H) antigen-disparate skin grafts and probes the extent to which allotolerance is established to major histocompatibility complex (MHC) antigens first encountered at metamorphosis. The work began with intrastrain skin grafting and mixed leucocyte culture (MLC) (Chapter 2) which confirmed that only minor H antigen differences exist between J strain Xenopus laevis individuals, thus making them suitable as an additional animal model to the X.laevis/X.gilli (LG) isogeneic hybrids availa

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3

Cunha, Wilton Darleans dos Santos. "Influência do exercício sobre a resposta imunológica de ratos desnutridos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-18112009-115338/.

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A desnutrição é capaz de induzir diversas alterações metabólicas afetando marcadamente a composição corporal e o sistema imunológico. O exercício físico, por sua vez, produz alterações no organismo para uma melhor capacidade de adaptação a situações de estresse. O desvio da situação de homeostase produzida pelo exercício físico induz uma reorganização de seus mecanismos funcionais, principalmente dos mecanismos endócrinos e imunológicos. Ainda é pouco conhecida a influência do exercício sobre a desnutrição e também as conseqüências sobre o sistema imunológico quando as duas variáveis são combi

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4

Paterson, D. J. "Differentiation in the thymus." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379914.

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5

Morris, Lucy. "Rhox4 : duplication, evolution and thymus organogenesis." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/11197.

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The thymus develops from the ventral portion of 3<sup>rd</sup> pharyngeal pouch endoderm. At E9.5 this region is marked by expression of the transcription factor <i>Rhox4, Rhox4 </i>may therefore have a role in the developing thymic primordia. <i>Rhox4 </i>is a member of the recently described <i>Rhox </i>family of homeobox-containing genes, which are present in 3 clusters on the mouse X chromosome and are primarily expressed in reproductive and extra-embryonic tissues. The expression of <i>Rhox4 </i>in the thymus, in addition to the testis and placenta makes it unique amongst family members.

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6

Aw, Danielle Pei Shan. "Age-Associated Alterations in the Murine Thymus." Thesis, Royal Veterinary College (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487448.

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The immune system progressively declines with age, which is associated with an increase in susceptibility and severity of infections, cancers and autoimmune diseases. Of all alterations, involution of the'thymus is the most dramatic and ubiquitous resulting in decreased exportation of na'ive T cells. This is linked with constriction of T cell diversity, alterations in their phenotype and function and corrosion of telomeres due to replicative senescence. These changes are believed to be a major driving factor in immunosenescence. The precise mechanisms regulating thymic atrophy remain obscure,

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7

Smith, R. C. "The regulation of thymus myosin filament assembly." Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372901.

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8

Tanaka, Yujiro. "Selection of T cells in the thymus." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294749.

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9

Gordon, Julie. "Lineage and molecular analysis of thymus organogenesis." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/13937.

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The current literature describes two conflicting hypotheses regarding the embryonic origin of the TE. The first aim of this thesis was to clarify the role of the pharyngeal ectoderm in thymus organogenesis using two independent experimental approaches. Firstly, direct assessment via a lineage analysis found no evidence for physical ectodermal contribution to the TE. Secondly, an ectopic grafting model indicated that pharyngeal endoderm was sufficient to form a normal thymus. The molecular mechanisms underlying thymus development were investigated via <i>in situ</i> hybridisation of candidate g

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10

Wadhwa, Meenu. "Control of proliferation in the rat thymus." Thesis, Aston University, 1987. http://publications.aston.ac.uk/14530/.

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Quiescent rat thymocytes were stimulated to divide by a variety of agents. One such mitogen was the neurotransmitter acetylcholine which exhibited a biphasic action. Interaction with low affinity nicotinic receptors was linked with an obligatory requirement for magnesium ions whereas combination with high affinity muscarinic receptors induced mitosis only if calcium ions were present in the medium. Binding of acetylcholine to its muscarinic receptor enhanced calcium influx and increased intracellular calcium levels causing calmodulin activation, a necessary prelude to DNA synthesis and mitosis

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11

Zoran, Zeković. "Ekstrakcija timijana (Thymus vulgaris L.) superkritičnim ugljendioksidom." Phd thesis, Univerzitet u Novom Sadu, Tehnološki fakultet Novi Sad, 1999. https://www.cris.uns.ac.rs/record.jsf?recordId=71448&source=NDLTD&language=en.

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<strong>Apstrakt je obrađen tehnologijama za optičko prepoznavanje teksta (OCR).</strong>Ispitana je ekstrakcija timijana (<em>Thymus vulgaris L.</em>) primenom ugljendioksida u superkritičnom stanju kao ekstragensa. Razrađen je postupak tečne hromatografije pod visokim pritiskom (HPLC) za određivanje farmakolo&scaron;ki aktivnih fenolnih jedinjenja, timola i karvakrola, koji obezbeđuje visok stepen reproduktivnosti određivanja (za timol K<sub>w</sub> = 1,29%). Za kvalitativnu i kvantitativnu analizu proizvoda na bazi timijana, etarskog ulja i ekstrakata, primenjen je metod gasne hromatografij

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12

MOHAMED, Nahid. "Comparison of Fetal Thymus Size in Normal and Preeclamptic Pregnancies: Is Thymus Size Smaller in Fetuses of Women with Preeclampsia?" Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/10003.

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Objective To determine whether the thymus is smaller in the fetuses of preeclamptic mothers than in those of normal controls. Methods This was a cross-sectional, prospective, comparative study of sonographically-determined fetal thymus measurements in 39 pregnancies with preeclampsia and 70 healthy pregnancies. Results Both the diameter and the perimeter of the fetal thymus were significantly smaller in pregnancies with preeclampsia than in healthy controls. The means of the thymus diameter were 28.6 ± 5.9 and 32.9 ± 4.5 mm and of the thymus perimeters 80.9 ± 16.5 and 93.1 ± 16.6 mm for preec

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13

Kimmig, Sonja. "Thymus-naive und zentral-naive humane Th-Lymphozyten." [S.l.] : [s.n.], 2003. http://www.diss.fu-berlin.de/2003/219/index.html.

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14

Veinotte, Linnea Lora. "Novel pathway of thymus-dependent NK cell development." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/31179.

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Natural killer (NK) cells are the major lymphocytes of the innate immune system, but their developmental pathway is not fully defined. It is commonly assumed that all NK cells develop in the bone marrow. In this thesis, I describe a novel thymus-dependent pathway of NK cell development that is specific to those in the thymus and lymph nodes. Microarray analysis revealed TCRγ mRNA expression in NK cells. Genomic and RT-PCR showed that some NK cells have rearranged TCRγ genes while TCRβ and TCRδ genes are in germline order. NK cells with rearranged TCRγ ( Tcrγ⁺ NK cells) were absent in nude mice

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15

Wang, Jian Xue. "Expression of the ST3 antigen in rat thymus." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=26172.

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By techniques of immunohistochemical staining, flow cytometry, and image analysis, the present study demonstrated the following: (1) The ST3 antigen is expressed on the surface of thymocytes of young rats, and decreases in both percentage and intensity with increasing age (after 12 months). (2) The ST3 antigen also is expressed on the surface of thymic nurse cells. Although the majority of lymphoid cells within nurse cells also bear the ST3 antigen, a subpopulation contains lymphocytes that do not. These results suggest that the ST3 antigen may be a useful new marker for cortical lymphocytes,

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16

Kinsella, Francesca Anna Maria. "Mechanisms regulating T cell selection in the thymus." Thesis, University of Birmingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433639.

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17

Glass, Rainer. "Purinergic signalling in endocrine organs : testis, thyroid, thymus." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250178.

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18

Bertrand-Blanchard, Françoise. "Carcinome neuroendocrine du thymus secretant de la calcitonine." Angers, 1993. http://www.theses.fr/1993ANGE1062.

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19

Lin, Shih-Yao. "Analyse des evenements de selection dans les thymus." Aix-Marseille 2, 1998. http://www.theses.fr/1998AIX22013.

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La selection positive est le procede permettant aux thymocytes dont les complexes tcrs se liant aux complexes du soi peptide-molecule du cmh, dechapper a la mort cellulaire programmee, tandis que les thymocytes dont les tcrs n'ont aucune affinite pour les molecules du soi du cmh, meurent. La selection negative elimine ou inactive les clones de thymocytes dont les tcrs se fixent aux complexes du soi peptide-molecule du cmh avec haute affinite/avidite. Suite a ces deux evenements de la selection thymique, les seuls thymocytes fonctionnels, autorises a vivre et a maturer sont ceux pouvant etre ac

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20

Besin, Gilles. "Genetic screen for positive selection in the thymus." [S.l. : s.n.], 2006.

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21

Andrew, Deborah Frances. "Thymic atrophy and the role of interleukin 7." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249322.

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22

Азаров, А. А. "Відмінності морфофункціонального стану тимуса при різних за перебігом і етіологією видах запалення". Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/60604.

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23

Darrigues, Julie. "Variations du développement thymique des lymphocytes T régulateurs : influence de l’âge et de la génétique." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30103.

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Les lymphocytes T régulateurs CD4+ Foxp3+ (Treg) sont des acteurs clés de l’homéostasie du système immunitaire. Grâce à des fonctions immunosuppressives, les Treg contrôlent la survenue et l’amplitude des réponses immunitaires. Ils sont ainsi essentiels à la prévention de pathologies auto-immunes et inflammatoires chroniques. Comme les autres lymphocytes Tαβ (Tconv), les Treg se différencient dans le thymus à partir d’un même précurseur hématopoïétique. Bien qu’encore méconnu, le développement des Treg diffère de celui des Tconv par la nature des interactions ou des signaux échangés entre les

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24

Schulte, Antje. "Expressionsmuster "Gewebe-spezifischer" Antigene in Thymus-Epithelzellen der Maus." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=963776061.

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25

Silva, Domingos Alberto B. "Expression and functional analysis of neuropeptides in the thymus." Thesis, Royal Veterinary College (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522745.

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26

Stephan, Nicolas. "Involution von Thymus und Peyer Plaques durch Interferon-α". Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-158645.

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27

Kamašina, Violeta. "Moteriškasis dvinamiškumas Lietuvos floros Thymus genties rūšyse ir hibriduose." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20101125_190734-49932.

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Thymus genties rūšims būdingas moteriškasis dvinamiškumas, kai rūšies populiaciją sudaro drauge augantys dvilyčiai ir vienalyčiai moteriški individai. Tiek skirtingose rūšyse, tiek tos pačios rūšies skirtingose augavietėse dvilyčių ir vienalyčių moteriškų individų santykis gali labai skirtis. Iki šiol nėra pilnai išaiškinta, kokie veiksniai ir kaip gali įtakoti šiuos skirtumus. Šio darbo tikslas buvo įvertinti Lietuvos floros Thymus genties rūšių Thymus pulegioides L., Thymus serpyllum L. bei jų tarprūšinio hibrido Thymus × oblongifolius Opiz lyties polimorfizmą nulemiančio moteriškojo dvinami

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28

Palmer, Donald B. "Expression and functional analysis of neuropeptides in the thymus." Thesis, Royal Veterinary College (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497525.

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29

Vidžiūnaitė, Gerda. "Fenolinių junginių įvairavimo čiobrelių (Thymus spp.) žolės mėginiuose tyrimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140630_134616-75186.

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Tyrimo objektas ir metodai: Thymus spp. genties augalų žolė. Fenoliniai junginiai nustatyti spektrofotometrijos metodais, timolis – efektyviosios skysčių chromatografijos metodu. Darbo tikslas: ištirti čiobrelio žolėje esančių fenolinių junginių kiekio ir laisvųjų radikalų surišimo gebos įvairavimą Lietuvos klimato sąlygomis augančių čiobrelių žolės mėginiuose. Darbo uždaviniai: surinkti čiobrelių žolės žaliavų mėginius skirtinguose Lietuvos regionuose; spektrofotometrijos metodu nustatyti ir įvertinti suminį fenolinių junginių kiekį čiobrelio žolės mėginiuose; spektrofotometrijos metodu nusta

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30

Carvalho, Ricardo Manuel Simões. "Avaliação da atividade antimicrobiana do óleo essencial Thymus mastichina." Master's thesis, Universidade da Beira Interior, 2012. http://hdl.handle.net/10400.6/1128.

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O presente trabalho encontra-se dividido em dois capítulos distintos: Investigação e Estágio em farmácia comunitária. No primeiro capítulo aborda-se a investigação realizada no Centro de Investigação em Ciências da Saúde da Universidade da Beira Interior (CICS-UBI); o segundo capítulo descreve o estágio realizado na Farmácia Central. Os óleos essenciais são misturas complexas de componentes voláteis provenientes de plantas. A sua reconhecida bioatividade tem sustentado o seu uso empírico e tradicional. O aumento exponencial das resistências dos microrganismos aos antimicrobianos correntemente

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31

Miyasaka, Masayuki. "Characterization of lymphatic and venous emigrants from the thymus." Kyoto University, 1992. http://hdl.handle.net/2433/168723.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・論文博士<br>博士(医学)<br>乙第7901号<br>論医博第1391号<br>新制||医||545(附属図書館)<br>UT51-92-P319<br>(主査)教授日合弘, 教授淀井淳司, 教授桂義元<br>学位規則第4条第2項該当

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32

Rousseau, Matthieu. "Rôles des phospholipases A2 dans la biologie du thymus." Doctoral thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/25749.

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Les précurseurs des lymphocytes T appelés thymocytes se développent dans le thymus, un organe lymphoïde primaire, via différents processus de sélections aboutissant à l’élimination par apoptose de ceux qui sont inutiles ou dangereux (autoréactifs). Le développement des thymocytes nécessite de nombreuses molécules comme les cytokines et les chimiokines. Bien que le rôle des médiateurs lipidiques dans l’immunité soit bien décrit, leur rôle dans la maturation des thymocytes l’est peu. Nous avons étudié le rôle de la phospholipase A2 cytosolique du groupe IVA (cPLA2α), une enzyme clé pour la biosy

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33

Elsaid, Ramy. "Ontogeny of hematopoietic progenitor cells seeding the embryonic thymus." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7024.

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Au cours du développement embryonnaire, de multiples vagues de progéniteurshématopoïétiques ayant un potentiel de lignage distinct sont régulées de manièredifférentielle dans le temps et dans l'espace. Deux vagues de progéniteurs thymiques (TSPs)colonisent le thymus foetal, où elles contribuent à l'organogenèse thymique et àl'homéostasie. Les TSPs de la première vague génèrent des lymphocytes spécialisés lorsl'embryogenèse et restent dans les tissus tout au long de la vie. De plus en plus de preuves de l’hétérogénéité et de l’organisation stratifiée du système hématopoïétique mènent à une hypo

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34

Ulyanchanka, Sviatlana. "Identification of stem/progenitor cells in the postnatal thymus." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/11736.

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The thymus is the principal site of T-cell development and maturation. Failure to develop a functional thymus leads to severe immunodeficiency, while partially incorrect function of the organ can lead to a variety of autoimmune diseases as well as higher risk for infections and cancer. The thymus is organized into cortical and medullary regions, which are functionally distinct. The diverse array of thymic epithelial cells (TEC) are the key components of the thymic stroma, both the cortical and medullary TEC subsets are responsible for the establishment of a self-tolerant and self-restricted T-

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35

Gillard, Geoffrey Oliver. "Developmental mechanisms regulate the generation and maintenance of mTEC heterogeneity and peripheral antigen expression /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8318.

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36

Kölare, Susanne. "Studies on thymocyte subpopulations in guinea pigs with special reference to proliferation and differentiation." Stockholm : Kongl. Carolinska Medico Chirurgiska Institutet, 1989. http://catalog.hathitrust.org/api/volumes/oclc/20784737.html.

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37

Guiet, Pascal. "Etude du microenvironnement et des populations lymphocytaires du thymus humain chez la souris SCID humanisée infectée par le virus de l'immunodéficience humaine de type 1 (VIH-1)." Paris 5, 1995. http://www.theses.fr/1995PA05P005.

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38

Asaad, Kamil. "Comparative histology of human skin." Thesis, University of Bradford, 2010. http://hdl.handle.net/10454/5711.

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There are 5 distinct aspects to this study. (i) Two histological stains for collagen were compared against each other for the first time, namely Herovici's technique and picrosirius-polarization. (ii) Skin samples from embalmed cadaveric tissue from human cadavers were compared against samples taken from surgical patients. (iii) Skin samples were studied from different regions of the body to assess if dermal structure correlates with scarring potential. (iv) Skin samples were sectioned in a plane parallel to the epidermis to gain further insight into dermal structure. (v) A novel basemen

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39

Beijleveld, Leonardus Johannes Josephus. "Thymus dependent autoimmunity thymic selection versus peripheral tolerance in the model of experimental Cyclosporin-A induced autoimmunity /." [Maastricht : Maastricht : Rijksuniversiteit Limburg] ; University Library, Maastricht University [Host], 1996. http://arno.unimaas.nl/show.cgi?fid=6692.

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40

Komesli, Sylviane. "Structure et fonctions des centrosomes isolés à partir de thymocytes de veau." Grenoble 1, 1991. http://www.theses.fr/1991GRE10016.

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Dans les cellules interphasiques, le centrosome joue le role de centre de nucleation du reseau mitrobutulaire. Lors de la mitose, le centrosome se duplique. Chaque centrosome sert alors de centre organisateur pour une moitie du fuseau mitotique. Les bases moleculaires des deux fonctions centrosomales, nucleation et replication, sont obscures. Un obstacle majeur dans l'etude des centrosomes est le cout et les faibles quantites de materiel obtenues par les preparations habituelles. Le point de depart de ce travail de these a consiste a mettre au point une methode de preparation en masse de centr

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41

Aboussaouira, Touria. "Etude de la prolifération des lymphocytes thymiques du rat Wistar par analyse d'images au SAMBA 200 : ontogenèse du thymus et action de trois hormones sur la prolifération chez le rat de 21 jours, le 17[bêta]-oestradiol, la prolactine et l'insuline." Grenoble 1, 1987. http://www.theses.fr/1987GRE10062.

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42

Broers, Anna Elisabeth Clasine. "Interleukin-7 and hematopoietic stem cell transplantation: beyond the thymus." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10697.

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43

Roxanis, Ioannis. "Studies in the thymus of early-onset myasthenia gravis patients." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301233.

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44

Farley, Alison. "Characterisation of epithelial progenitor cells for human and mouse thymus." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3870.

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The thymus is a complex cellular structure made up of several interdependent cell types and is the primary site for T cell development. A population of fetal thymic epithelial cells (TEC), marked by MTS20 and MTS24, when grafted in vivo can generate a functional thymus containing all thymic epithelial cells and is capab,e of supporting T cell differentiation. Further analysis using in vivo grafting experiments have determined the endoderm as the sole origin for all major thymic epithelial subsets. These findings suggest the possibility that a bipotent thmic epithelial progenitor cell (TEPC) gi

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45

Peters, Gavin. "Investigating the development of regulatory T cells in the thymus." Thesis, Queen Mary, University of London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528966.

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46

Weiss, Julia Miriam. "Characterization of thymic hyperplasia associated with autoimmune Myasthenia Gravis : role of the chemokines CXCL12 and CXCL13." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA114831/document.

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La myasthénie (Myasthenia Gravis) est une maladie neuromusculaire impliquant des auto-anticorps dirigés majoritairement contre le récepteur à l’acétylcholine (RACh) et entrainant une fatigabilité musculaire. Ces auto-anticorps pathogènes sont produits principalement par le thymus qui présente une hyperplasie caractérisée par le développement de centres germinatifs ectopiques. De récentes études ont démontré la surexpression de chimiokines dans le thymus des patients et la présence anormale de vaisseaux sanguins de type HEV (cellules endothéliales à paroi haute). L’objectif de ma thèse a été de

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47

Charaix, Jonathan. "La cytokine lymphotoxine α et le facteur de transcription Aire régulent la signature suppressive des lymphocytes T régulateurs". Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0507.

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Les lymphocytes T régulateurs (Treg) de phénotype Foxp3+ inhibent en périphérie les réactions immunitaires autoréactives, prévenant ainsi l’apparition de pathologies inflammatoires et auto-immunes. Des essais cliniques prometteurs basés sur l’injection de Treg restent actuellement limités par la quantité de cellules requise et nécessitent donc l’identification de molécules aptes à promouvoir l’activité suppressive des Treg afin de faciliter leur utilisation en thérapie.Des résultats préliminaires de mon équipe indiquent que les Treg expriment fortement la cytokine lymphotoxine α (LTa), suggéra

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McCann, Michael T. "Tools for Automated Histology Image Analysis." Research Showcase @ CMU, 2015. http://repository.cmu.edu/dissertations/678.

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In this thesis, we present three image processing tools inspired by and designed for histology image analysis. Histology, which is the examination of biological tissue under a microscope, is a critical technique in biomedical research and clinical practice. While slide preparation and imaging is increasingly becoming automated, the analysis of the resulting histology images is not: even routine analyses still require the trained eyes of a pathologist. In our work, we aim to understand histology images as a class of signals and develop tools to aid in the automated analysis of these signals. Ou

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Butterworth, Rosalind J. "The histology of human granulating wounds." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/34293.

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1. The prime aim of this study was to investigate the structure and cellularity of human granulation tissue, by the taking of punch biopsies from clinical wounds, a method not previously reported in wound research. It was intended both to further the understanding of wound biology, and to provide baseline information for clinical trials of therapeutic agents, such as dressing materials and growth factors. 2. To evaluate the validity of the universally used animal models of wound healing, and the extent to which data from them can be extrapolated to the human wound. 3. To relate histological cr

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Miszkiewicz, Justyna J. "Ancient human bone histology and behaviour." Thesis, University of Kent, 2014. https://kar.kent.ac.uk/38319/.

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