Journal articles: 'Histology, Pathological'

1

VIRCHOW, RUDOLF. "As Based upon Physiological and Pathological Histology." Nutrition Reviews 47, no. 1 (April 27, 2009): 23–25. http://dx.doi.org/10.1111/j.1753-4887.1989.tb02747.x.

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Simeone, C., A. Guerini, T. Zambolin, V. De Luca, E. Frego, G. P. Da Pozzo, V. Magri, and S. Cosciani Cunico. "Bladder Wall Histology and Duration of Obstruction." Urologia Journal 59, no. 1 (February 1992): 26–30. http://dx.doi.org/10.1177/039156039205900106.

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In BPH patients, obstruction leads to a progressive modification in the structure of the bladder wall, with histo-pathological changes which are often irreversible. In order to detect these changes and their possible correlation with function, muscle biopsies of the bladder were taken from 28 patients during endoscopic resection for benign prostatic hyperplasia. The samples were examined by means of electron microscope to show ultrastructural charges. The magnitude of the lesions can be correlated to function, seriousness and duration of the obstruction. Detecting histo-pathological damage can justify earlier treatment in obstructed BPH patients, in order to avoid those bladder lesions, which are the probable cause of clinical disorders which may persist even after therapy of the adenoma.

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Suo, Liye, Martha Caicedo Murillo, Brian Gallay, and Reut Hod-Dvorai. "Discrepancy Analysis between Histology and Molecular Diagnoses in Kidney Allograft Biopsies: A Single-Center Experience." International Journal of Molecular Sciences 24, no. 18 (September 7, 2023): 13817. http://dx.doi.org/10.3390/ijms241813817.

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Histology diagnosis is essential for the monitoring and management of kidney transplant patients. Nowadays, the accuracy and reproducibility of histology have been criticized when compared with molecular microscopy diagnostic system (MMDx). Our cohort included 95 renal allograft biopsies with both histology and molecular diagnoses. Discrepancies between histology and molecular diagnosis were assessed for each biopsy. Among the 95 kidney allograft biopsies, a total of 6 cases (6%) showed clear (n = 4) or borderline (n = 2) discrepancies between histology and molecular diagnoses. Four out of the six (67%) were cases with pathologically and clinically confirmed active infections that were diagnosed as mild to moderate T-cell-mediated rejection (TCMR) with MMDx. Two cases showed pathological changes that were not sufficient to make a definitive diagnosis of active rejection via histology, while MMDx results showed antibody-mediated rejection (ABMR). In addition, there were six cases with recurrent or de novo glomerular diseases diagnosed only via histology. All other biopsy results were in an agreement. Our results indicate that histology diagnosis of kidney allograft biopsy is superior to molecular diagnosis in the setting of infections and glomerular diseases; however, MMDx can provide helpful information to confirm the diagnosis of active ABMR.

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Fukuzawa, Hiroaki, Takeshi Aoba, Makiko Yoshida, Hideto Iwafuchi, Junki Koike, Hiroaki Kitagawa, Naoto Urushihara, Akiko Yokoi, and Kosaku Maeda. "Pathological Features of the Unilateral Favorable Histology Nephroblastoma with Relapse." Fetal and Pediatric Pathology 34, no. 6 (October 16, 2015): 383–90. http://dx.doi.org/10.3109/15513815.2015.1095258.

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Malmgaard-Clausen, Nikolaj Moelkjaer, Michael Kjaer, and Stephanie G. Dakin. "Pathological Tendon Histology in Early and Chronic Human Patellar Tendinopathy." Translational Sports Medicine 2022 (October 4, 2022): 1–9. http://dx.doi.org/10.1155/2022/2799665.

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The present pilot study investigated the extent of histological tissue changes in both chronic tendinopathy and in individuals that display early clinical signs of tendinopathy. The study included 8 individuals of whom 3 were healthy without any tendon symptoms, 2 had early symptoms (1–2 months), and 3 had chronic symptoms (>3 months) from their patellar tendons. Percutaneous needle biopsy samples were obtained from the affected tendon tissue region. Biopsy samples were stained with Haematoxylin & Eosin, and multiplex immunofluorescence staining was performed for markers of inflammation and resolution. Both early and chronic stage patellar tendon biopsy samples from this small patient cohort exhibited expansion of the interfascicular matrix (IFM) and endotenon regions together with increased cellularity and vascularity. These histological observations were moderate in early tendinopathy, whereas they were more pronounced and associated with marked disruption of tissue architecture in chronic tendinopathy. Early stage tendinopathic patellar tendons expressed markers associated with an activated phenotype of fibroblasts (CD90, CD34), macrophages (S100A8), and endothelial cells (ICAM1, VCAM1). These tissues also expressed enzymes implicated in inflammation (PTGS2, 15PGDH) and resolution (ALOX12) and the proresolving receptor ERV1. Immunopositive staining for these markers was predominantly located in the IFM regions. These preliminary findings suggest that mild to moderate structural histological changes including expansion of IFM and endotenon regions are pathological features of early tendinopathy, and support inflammatory and resolving processes are active in early-stage disease. Further investigation of the cellular and molecular basis of early-stage tendinopathy is required to inform therapeutic strategies that prevent the development of irreversible chronic tendon disease.

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Awad, Ziad T., Thomas C. Smyrk, Robert E. Marsh, Tetsuya Tomonaga, Yutaka Shiino, and Charles J. Filipi. "Eosinophilic esophagitis: Is histology specific for the clinico-pathological syndrome." Gastroenterology 114 (April 1998): A62. http://dx.doi.org/10.1016/s0016-5085(98)80249-7.

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Dhir, R. "Prediction by Quantitative Histology of Pathological Stage in Prostate Cancer." Yearbook of Pathology and Laboratory Medicine 2006 (January 2006): 146–47. http://dx.doi.org/10.1016/s1077-9108(08)70107-5.

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Pepe, P., A. Galia, F. Fraggetta, G. Grasso, R. Allegro, and F. Aragona. "Prediction by quantitative histology of pathological stage in prostate cancer." European Journal of Surgical Oncology (EJSO) 31, no. 3 (April 2005): 309–13. http://dx.doi.org/10.1016/j.ejso.2004.12.002.

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Erber, Ramona, and Arndt Hartmann. "Histology of Luminal Breast Cancer." Breast Care 15, no. 4 (2020): 327–36. http://dx.doi.org/10.1159/000509025.

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Background: Invasive breast cancer (IBC) can be categorized into prognostic and predictive molecular subtypes (including luminal breast cancer) using gene expression profiling. Luminal IBC comprises a variety of histological subtypes with varying clinical and pathological features. Summary: IBC of no special subtype is the most common histological subtype in general and likewise within luminal IBC. Classical invasive lobular breast cancer, typically clustering into luminal subgroup, is characterized by discohesive growth and loss of E-cadherin expression. Infrequent, morphologically distinct luminal IBC subtypes are tubular, invasive cribriform, mucinous, and invasive micropapillary carcinomas. Breast carcinoma with apocrine differentiation, with characteristic expression of androgen receptor (AR), often clusters into the luminal AR category. Rarely, neuroendocrine neoplasms of the breast can be seen. IBC of the male breast usually matches with the luminal subtype. Key Messages: Independently from histological subtypes, invasive breast cancer (IBC) can be divided into molecular subtypes based on mRNA gene expression levels. Using this molecular subtyping, risk scores based on gene expression profiling (established for hormone receptor-positive, HER2-negative IBC), grading, and Ki-67 index, prognosis of patients with luminal breast cancer and response to chemotherapy can be predicted. In routine diagnostics, the expression of estrogen receptor (ER) and progesterone receptor (PR), HER2 status, and the proliferation rate (Ki-67) are used to determine a surrogate (molecular-like) subtype. Within luminal(-like) IBC, no special subtype and invasive lobular breast carcinoma are the most common histological subtypes. Other rare histological subtypes (e.g., tubular carcinoma) should be recognized due to their distinct clinical and pathological features.

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Luo, Ju Dong, Xu Jing Lu, Ling Chen, Yan Ma, Ying Ze Kong, Yang Ling, Shu Yu Zhang, Jian Ping Cao, and Xi Fa Zhou. "The Relationship of Pathological Datas of Gastric Cancer Patients after Radical Gastrectomy with Radiotherapy." Advanced Materials Research 641-642 (January 2013): 828–33. http://dx.doi.org/10.4028/www.scientific.net/amr.641-642.828.

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Mdthod :110 gastric cancer patients were selected from Feb 2004 to Jan 2006, who had complete pathological data and were underwent radical resection. All patients were diagnosed by endoscopy, preoperative histologic diagnosis and exclusion from distant metastasis, using D1 or D2 lymph node dissection, postoperative pathology confirmed stump negative. Univariate analysis was applied on the pathologic information and multivariate analysis was applied based on the univariate analysis. Result :(1)Univariate analysis showed that tumor diameter、histology、vascular invasion、lymphatic vessel invasion and neural invasion were correlated with T/N classification.Multivariate analysis showed that vascular invasion and lymphatic vessel invasion were correlated with T classification and lymphatic vessel invasion was associated with N classification. (2) For T and N stages, lymphatic vessel invasion was strongly related factor. Conclusion: For T and N stages,, lymphatic vessel invasion was strongly relevant factor. For patients with confirmed lymphatic vessel invasion, postoperative adjuvant radiotherapy is suggested.

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RENSHAW, ANDREW A. "TESTICULAR CALCIFICATIONS: INCIDENCE, HISTOLOGY AND PROPOSED PATHOLOGICAL CRITERIA FOR TESTICULAR MICROLITHIASIS." Journal of Urology 160, no. 5 (November 1998): 1625–28. http://dx.doi.org/10.1016/s0022-5347(01)62364-4.

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Brambilla, Cecilia, Alexandra Rice, and Andrew G. Nicholson. "Histology of Pulmonary and Bronchiolar Disorders in Connective Tissue Diseases." Seminars in Respiratory and Critical Care Medicine 40, no. 02 (April 2019): 147–58. http://dx.doi.org/10.1055/s-0039-1684029.

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AbstractConnective tissue diseases (CTDs) are a heterogeneous group of disorders, acquired or hereditary, involving an autoimmune-mediated inflammation of connective tissues in the whole body. Lung involvement is common with CTDs, and associated with significant morbidity and mortality. Each compartment of the lung may be affected, often simultaneously, depending on the type of CTD. In addition, the lung may show pathological changes related to treatment, such as infection, drug reaction, and neoplasia. A multidisciplinary approach to diagnose these patients is essential and incorporates radiological and clinical as well as pathological data. In this review we describe the patterns of lung disease associated with common CTDs, lung disease in pediatric CTD patients, and newly recognized conditions.

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Truong, My, Till Dreier, Johan Wassélius, Lena Sundius, Ana Persson, Goran Lovric, Anne Bonnin, Isabel Goncalves, and Martin Bech. "Sub-micrometer morphology of human atherosclerotic plaque revealed by synchrotron radiation-based μCT—A comparison with histology." PLOS ONE 17, no. 4 (April 26, 2022): e0265598. http://dx.doi.org/10.1371/journal.pone.0265598.

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Histology is a long standing and well-established gold standard for pathological characterizations. In recent years however, synchrotron radiation-based micro-computed tomography (SRμCT) has become a tool for extending the imaging of two-dimensional thin sections into three-dimensional imaging of tissue blocks, enabling so-called virtual histology with arbitrary clipping planes, volumetric rendering and automatic segmentation. In this study, we present a thorough characterization of human carotid plaques after endarterectomy of patients with stroke or transient ischemic attack (TIA), investigating several different pathologic structures using both SRμCT and histology. Phase-contrast SRμCT was performed with two different magnifications (voxel sizes 6.5 μm and 0.65 μm, respectively), and histology was performed with multiple different stainings (Alpha-actin, Glycophorin A, von Kossa, Movat, CD68). The 0.65 μm high-resolution SRμCT was performed on selected areas with plaque typical relevant morphology, identified on the 6.5 μm low-resolution SRμCT. The tomography datasets were reconstructed with additional 3D volume rendering and compared to histology. In total, nine different regions with typical pathologic structures were identified and imaged with high-resolution SRμCT. The results show many characteristics typical for advanced atherosclerotic plaques, clinically relevant, namely ruptures with thrombosis, neo-vascularization, inflammatory infiltrates in shoulder regions, lipid rich necrotic cores (LRNC), thin fibrous cap, calcifications, lumen irregularities, and changes in vessel wall structures such as the internal elastic membrane. This method’s non-destructive nature renders details of micro-structures with an excellent visual likeness to histology, with the additional strength of multiplanar and 3D visualization and the possibility of multiple re-scans.

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Truong, My, Till Dreier, Johan Wassélius, Lena Sundius, Ana Persson, Goran Lovric, Anne Bonnin, Isabel Goncalves, and Martin Bech. "Sub-micrometer morphology of human atherosclerotic plaque revealed by synchrotron radiation-based μCT—A comparison with histology." PLOS ONE 17, no. 4 (April 26, 2022): e0265598. http://dx.doi.org/10.1371/journal.pone.0265598.

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Histology is a long standing and well-established gold standard for pathological characterizations. In recent years however, synchrotron radiation-based micro-computed tomography (SRμCT) has become a tool for extending the imaging of two-dimensional thin sections into three-dimensional imaging of tissue blocks, enabling so-called virtual histology with arbitrary clipping planes, volumetric rendering and automatic segmentation. In this study, we present a thorough characterization of human carotid plaques after endarterectomy of patients with stroke or transient ischemic attack (TIA), investigating several different pathologic structures using both SRμCT and histology. Phase-contrast SRμCT was performed with two different magnifications (voxel sizes 6.5 μm and 0.65 μm, respectively), and histology was performed with multiple different stainings (Alpha-actin, Glycophorin A, von Kossa, Movat, CD68). The 0.65 μm high-resolution SRμCT was performed on selected areas with plaque typical relevant morphology, identified on the 6.5 μm low-resolution SRμCT. The tomography datasets were reconstructed with additional 3D volume rendering and compared to histology. In total, nine different regions with typical pathologic structures were identified and imaged with high-resolution SRμCT. The results show many characteristics typical for advanced atherosclerotic plaques, clinically relevant, namely ruptures with thrombosis, neo-vascularization, inflammatory infiltrates in shoulder regions, lipid rich necrotic cores (LRNC), thin fibrous cap, calcifications, lumen irregularities, and changes in vessel wall structures such as the internal elastic membrane. This method’s non-destructive nature renders details of micro-structures with an excellent visual likeness to histology, with the additional strength of multiplanar and 3D visualization and the possibility of multiple re-scans.

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Truong, My, Till Dreier, Johan Wassélius, Lena Sundius, Ana Persson, Goran Lovric, Anne Bonnin, Isabel Goncalves, and Martin Bech. "Sub-micrometer morphology of human atherosclerotic plaque revealed by synchrotron radiation-based μCT—A comparison with histology." PLOS ONE 17, no. 4 (April 26, 2022): e0265598. http://dx.doi.org/10.1371/journal.pone.0265598.

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Histology is a long standing and well-established gold standard for pathological characterizations. In recent years however, synchrotron radiation-based micro-computed tomography (SRμCT) has become a tool for extending the imaging of two-dimensional thin sections into three-dimensional imaging of tissue blocks, enabling so-called virtual histology with arbitrary clipping planes, volumetric rendering and automatic segmentation. In this study, we present a thorough characterization of human carotid plaques after endarterectomy of patients with stroke or transient ischemic attack (TIA), investigating several different pathologic structures using both SRμCT and histology. Phase-contrast SRμCT was performed with two different magnifications (voxel sizes 6.5 μm and 0.65 μm, respectively), and histology was performed with multiple different stainings (Alpha-actin, Glycophorin A, von Kossa, Movat, CD68). The 0.65 μm high-resolution SRμCT was performed on selected areas with plaque typical relevant morphology, identified on the 6.5 μm low-resolution SRμCT. The tomography datasets were reconstructed with additional 3D volume rendering and compared to histology. In total, nine different regions with typical pathologic structures were identified and imaged with high-resolution SRμCT. The results show many characteristics typical for advanced atherosclerotic plaques, clinically relevant, namely ruptures with thrombosis, neo-vascularization, inflammatory infiltrates in shoulder regions, lipid rich necrotic cores (LRNC), thin fibrous cap, calcifications, lumen irregularities, and changes in vessel wall structures such as the internal elastic membrane. This method’s non-destructive nature renders details of micro-structures with an excellent visual likeness to histology, with the additional strength of multiplanar and 3D visualization and the possibility of multiple re-scans.

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Wang, Qian, Yaning Zhang, Meng Ru, Changchuan Jiang, Jessica Tran, Juan P. Wisnivesky, and Rajwanth Veluswamy. "Radical surgery in malignnant pleural mesothelioma (MPM): An analysis of SEER database." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): 8554. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.8554.

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8554 Background: MPM is an aggressive malignnancy with poor overall prognosis. A combined treatment approach involving radical surgery (RS), radiation (RT) and chemotherapy (CT) provide improved survival compared to systemic treatment alone. Selecting patients who may benefit from RS is challenging. The NCCN guidelines recommend that up to T3N1M0 (Stage IIIA) epithelioid or biphasic MPM should be considered for multimodality therapy incorporating RS. However, the impact of clinical and pathologic features within each histologic subtype of MPM on RS outcomes is unknown. Methods: MPM patients from the SEER 18 program from 2004-2015 were identified. Cox proportional hazard regression models were used to examine the independent contribution of several clinical and pathologic features on overall survival (OS) in patients who received RS vs those that did not. Results: A total of 5,498 MPM patients were identified, of which 531 underwent RS. Overall, RS was associated with improved OS in the multivariate model adjusting for important clinical and pathological characteristics (Table). When stratifying according to histology, epithelioid subtype was linked to improved OS with RS despite of the presence male gender, age > 60 years old, T3, T4 or N2 or above disease; and the OS improved among those who also underwent CT ± RT with RS. Patients with sarcomatoid histology also had OS benefit from RS (HR=0.59, 95%CI: 0.37-0.93), even those that were > 60 years old, but not among those with more advanced disease (T3/4, N2/3). Sarcomatoid patients who received CT ± RT (HR = 0.52, 95%CI: 0.30-0.90) also experienced OS benefit. Among biphasic histology, no OS benefit was found overall (P = 0.11) or within other high-risk clinical features except for those who were treated CT ± RT (HR = 0.64, 95%CI: 0.45-0.90). Conclusions: Our findings demonstrate that the presence of high-risk clinical and pathologic features does not impact OS benefit of RS in epithelioid MPM, however should be considered when deciding on RS in sarcomatoid and biphasic histologies. Poor prognostic histology especially sarcomatoid subtype may experience improved survival with RS if in conjunction with other treatment modalities.[Table: see text]

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Koskinas, John, Ilias P. Gomatos, Dina G. Tiniakos, Nikolaos Memos, Maria Boutsikou, Aspasia Garatzioti, Athanasios Archimandritis, and Alexander Betrosian. "Liver histology in ICU patients dying from sepsis: A clinico-pathological study." World Journal of Gastroenterology 14, no. 9 (2008): 1389. http://dx.doi.org/10.3748/wjg.14.1389.

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Knopman, David S. "Overview of Dementia Lacking Distinctive Histology: Pathological Designation of a Progressive Dementia." Dementia and Geriatric Cognitive Disorders 4, no. 3-4 (1993): 132–36. http://dx.doi.org/10.1159/000107354.

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Masterson, A. "Typically benign and typically malignant microcalcification with discordant histology: pathological-radiological review." European Journal of Cancer 38, no. 11 (March 2002): S143. http://dx.doi.org/10.1016/s0959-8049(02)80474-9.

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Dao, Aihua, and Chunhong Pan. "Advances in the Study of Pathological Histology and Pathogenesis of Endometrial Polyps." Current Research in Medical Sciences 2, no. 4 (December 2023): 47–53. http://dx.doi.org/10.56397/crms.2023.12.06.

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Endometrial polyps (EPs) are common gynecological diseases among women of childbearing age. They are formed by the proliferation of blood vessels and connective tissue in a portion of the endometrium, resulting in the formation of a polyp-like mass that protrudes into the uterine cavity and varies in size and number. Typically, the body of the uterus is the site of implantation of these polyp-like growths, which are attached to the medial wall of the uterine cavity by a long, thin tip. Irregular vaginal bleeding is the first clinical manifestation of endometrial polyps, and it can often lead to infertility. Studies have shown that the prevalence of endometrial polyps in the female population is approximately 25.0%. With the widespread use of hysteroscopic techniques in clinical practice, knowledge and diagnosis of endometrial polyps have significantly improved. However, pathological examination remains the “gold standard” for final diagnosis in clinical practice. This article aims to review the epidemiology, pathological histology, and pathogenesis of endometrial polyps to reveal their mechanisms and characteristics more accurately and guide further clinical research and treatment. The relevant progress in recent years in this field, both domestically and internationally, is reviewed below.

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Moroki, Takayasu, Yutaka Yoshikawa, Katsuhiko Yoshizawa, Airo Tsubura, and Hiroyuki Yasui. "Morphological analysis of the pancreas and liver in diabetic KK-Aymice treated with zinc and oxovanadium complexes." Metallomics 6, no. 9 (2014): 1632–38. http://dx.doi.org/10.1039/c4mt00087k.

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Rahmawati, Indra, Lailia Dwi Kusuma Wardhani, and Bagus Uda Palgunadi. "ANATOMICAL PATHOLOGY AND HISTOLOGICAL OF SMALL INTESTINAL ORGANS IN BROILER INFECTED WITH ASCARIDIA GALLI." International Journal of Tropical Veterinary and Biomedical Research 8, no. 2 (December 1, 2023): 51–54. http://dx.doi.org/10.21157/ijtvbr.v8i2.35096.

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Infection with Ascaridia galli still attacks poultry farms, especially chickens in Indonesia. This study aims to determine the causes of changes in anatomy pathological and histology in small intestine of broiler. The study was taken from Alif which had clinical symptoms of weakness and anorexia on July 5, 2022 in Gresik Jawa Timur. The results of anatomical pathology and histological examination showed changes in the duodenum and jejunum organs showing hemorrhagic and inflammatory cell infiltration. The results of parasite examination found A.galli worms in the lumen of the small intestine and A.galli worm eggs from feces. In this study, clinical symptoms and anatomy pathological and histology changes of the small intestine in the broiler were caused by infection with A. galli worms.

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Savu, Elena, Valeriu Șurlin, Liviu Vasile, Ileana Octavia Petrescu, Cristina Elena Singer, Nicolae-Daniel Pirici, and Stelian Stefanita Mogoanta. "Early-Onset Colorectal Cancer—A Retrospective Study from a Tertiary Referral Hospital in Romania." Diagnostics 14, no. 10 (May 19, 2024): 1052. http://dx.doi.org/10.3390/diagnostics14101052.

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Early-onset colorectal cancer emerges as a distinctive clinical and biological entity and is generally defined as the onset of colon or rectal neoplasia before the age of 50. Several reports describe an increasing incidence worldwide of colorectal cancers occurring in individuals younger than 50 years, along with particular histologic and molecular features. Although heredity may be an explanation in some cases with young-onset colorectal cancer, other driving factors remain partially unknown. The present study explores demographic, clinical, and pathological features within a group of patients diagnosed with colorectal cancer before the age of 50. It is a retrospective survey based on data collected between 2017 and 2023 within three surgical departments from a tertiary Romanian hospital. The clinical and pathological features we identified (later-stage disease, distal colon tumor localization, mucinous histology) are mainly superimposed with the existing data in the literature regarding this pathology. In order to lower the burden that colorectal neoplasia diagnosed in the young implies, a change of paradigm should be made in terms of establishing effective and targeted screening programs but also in the direction of enhancing complex clinical, pathological, and molecular diagnosis.

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Patard, J., N. Rioux-Leclercq, K. Bensalah, and P. Fergelot. "Biological significance of serum VEGF measurement in renal cell carcinoma." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 4596. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.4596.

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4596 Background: VEGF plays an important role in Renal Cell Carcinoma (RCC) tumor angiogenesis and is a relevant molecular target. Our objective was to correlate serum VEGF measurement to clinical, biological and pathological variables in renal tumors. Methods: 206 patients who were operated for a renal tumor at our institution were prospectively assessed for serum VEGF measurement (enzyme-linked immunosorbent assay, R&D systems). Informed consent was obtained in all cases. Symptoms at presentation, pre-operative biology (haemoglobin, WBC count, platelet count, serum creatinin, calcemia, CRP, ASAT, ALAT, gamma-glutamyltransferase (γGT), Alkaline Phosphatases), TNM stage, Fuhrman grade and final pathology (benign vs malignant histology, histologic subtype) were systematically recorded. Qualitative and quantitative variables were compared by using Chi-square (Fischer exact test) and Student t tests, respectively. Results: There were 128 males (62.1%) and 78 females (37.9%). 185 tumors were malignant at histology (89.8%) including 155 tumors with clear cell histology (83.8%). Median serum VEGF level was 361 ng/ml (41–3090). Mean serum VEGF was not significantly different between benign and malignant tumors as well as between clear cell and non clear cell carcinomas (p: 0.4 and 0.8 respectively). Serum VEGF was strongly associated with symptoms, T Stage (p: 0.0001), N Stage (p: 0.004), Fuhrman grade (p: 0.007) and tumor necrosis (p: 0.004) but not with M Stage (p: 0.3). Serum VEGF was also found to be strongly associated with: haemoglobin, CRP, platelet count (p: 0.0001) and Alkaline phosphatases (p: 0.001). A weaker association was found between serum VEGF and γGT, ASAT (p: 0.05) or ALAT (p: 0.09). Finally serum VEGF was associated with cancer specific survival (p: 0.01). Conclusion: Serum VEGF is strongly associated with most usual clinical, biological and pathological prognostic parameters in RCC. Serum VEGF measurement should be further evaluated for prognostic purpose as well as for treatment monitoring. No significant financial relationships to disclose.

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Nepal, Gopi, Pritam Gurung, Anik Jha, Durga Khadka, Resha Shrestha, and Basant Pant. "Pathological Laughing in a Patient with a Pontine Tumor." Nepal Journal of Neuroscience 20, no. 2 (July 21, 2023): 75–78. http://dx.doi.org/10.3126/njn.v20i2.52611.

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An 18-year-old man presented with the complaints of occasional headache and limb weakness associated with slurring of speech and purposeless laughing. Magnetic resonance imaging showed a diffuse altered signal intensity area involving the pons with asymmetrical expansion. The patient underwent surgical resection. Histology was suggestive of a WHO grade IV glioblastoma. Pathological laughing in a patient with a pontine lesion is a very rare presentation. Evidence for a mechanism of action underpinning how pontine lesions can cause such behavioral changes through the disruption of a network of cerebro-ponto-cerebellar pathways is discussed.

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Bonilla, E., and A. Prelle. "Application of nile blue and nile red, two fluorescent probes, for detection of lipid droplets in human skeletal muscle." Journal of Histochemistry & Cytochemistry 35, no. 5 (May 1987): 619–21. http://dx.doi.org/10.1177/35.5.3559182.

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Using frozen sections from human muscle biopsies, we assessed the value of Nile blue and Nile red, two fluorescent probes, as stains for lipid droplets in normal and pathological skeletal muscle fibers. In normal muscle, lipid storage disorders, and mitochondrial myopathies, Nile blue stained the lipid droplets as yellow-gold fluorescent structures. The lipid droplets were also seen as yellow-gold fluorescent structures in Nile red-stained sections, but the outstanding feature in these preparations was the staining of the membrane network of the muscle fibers and membrane proliferations in pathological muscle as red-orange fluorescent structures. These results suggest that both Nile blue and Nile red stains are useful for visualization of lipid droplets and membrane proliferations in pathological muscle biopsies.

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Yurova, Yu V., V. A. Ilina, E. V. Zinovev, and R. V. Vashetko. "Diagnostic algorithm for determining the risk of developing pathological types of scar tissue in patients with burn injury." Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations, no. 2 (August 3, 2022): 100–106. http://dx.doi.org/10.25016/2541-7487-2022-0-2-100-106.

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Relevance. The problem of the development of pathological scar tissue in combustiology is still relevant. It is necessary to determine a pathogenetically sound approach to the treatment of a burn wound that reduces the likelihood of the development of pathological scar tissue.Intention: To study the histological structure of the tissues from which skin scars are formed, to develop a diagnostic algorithm for predicting the development of pathological scars.Methodology. Tissue biopsies taken intraoperatively in the center and along the periphery of burn wounds before free autodermoplasty (FADP) were examined in 56 patients with burn injuries. In the selection zone, microcirculation parameters were determined by laser Doppler flowmetry (LDF) at the stage of treatment of burn wounds and during the formation of scar tissue. Clinical observation of patients was carried out for a year. Relationships between histology of tissues from which the scar would subsequently form, their perfusion indices before FADP and types of scar tissue were assessed over a year.Results and Discussion. It was revealed that pathological scar tissue develops from granulation tissue and fibrous-altered dermis. The possibility of predicting the formation of the type of scar tissue by determining perfusion (M) is shown: above 10 perfusion units (PE), pathological scar tissue arises from granulation tissue; less than 4 PE, a high risk of developing pathological scar tissue from fibrous-altered dermis. With perfusion (4≤M≤10) in the zone of burn defects, the dermis, elements of subcutaneous fat, fibrous layer of granulation tissue are histologically determined, and the risk of developing pathological scar tissue is minimal.Conclusion. Taking into account the revealed patterns, principles for predicting the formation of pathological scar tissue were justified based on perfusion parameters in various parts of the burn wound and histology at the early stages of treatment. Based on the results, an algorithm for diagnosing various types of scar tissue has been developed

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Rajchard J, J., and V. Rachard. "Papilloma squamocellulare in chaffinch (Fringilla coelebs)." Veterinární Medicína 48, No. 8 (March 30, 2012): 235–36. http://dx.doi.org/10.17221/5775-vetmed.

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In October 2000 there were netted and ringed passerines near Zliv in Ceske Budejovicearea, CzechRepublic. One female of chaffinch (Fringilla coelebs) with expressive pathological modifications on foot was catched. Histology investigation proved papilloma squamocellulare.

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Zago, Rodrigo de Rezende, Pedro Popoutchi, Lucas Santana Nova da Costa, and Marcelo Averbach. "Post-polypectomy surveillance interval based on flexible spectral color imaging enhancement (FICE) with magnifying zoom imaging for optical biopsy." Endoscopy International Open 06, no. 08 (August 2018): E1051—E1058. http://dx.doi.org/10.1055/a-0629-8985.

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Abstract Background and study aims Post-polypectomy surveillance interval (SI) is determined based on the number, size, and histology of colorectal polyps. Electronic chromoendoscopy in association with magnifying imaging colonoscopy allows “in vivo” polyp histology prediction. Colorectal polyps ≤ 5 mm can be resected and discarded without pathologic assessment if the endoscopic technology when used with high confidence provides ≥ 90 % agreement between the post-polypectomy SI and the SI based on pathological assessment. The aim of this study was to evaluate the agreement between the post-polypectomy SI based on flexible spectral color imaging enhancement (FICE) chromoendoscopy in association with magnified imaging and the pathology-based SI. Patients and methods Each diagnosed colorectal polyp received a histology prediction (neoplastic or non-neoplastic) based on the FICE capillary-vessel pattern classification. Each prediction was classified as high or low confidence. SI based on the FICE prediction was compared to the pathology-based SI recommendation according to the US Multi-Society Task Force on Colorectal Cancer guideline. Sensitivity, specificity and accuracy of FICE in diagnosing neoplastic lesions were compared with the pathology assessment. Interobserver and intraobserver agreement for FICE-based SI predictions was evaluated using the kappa coefficient. Results A total of 267 polyps had histology prediction assessed with high confidence in 136 patients. Sensitivity of FICE was 98.7 % (95 % CI: 93.5 – 99.3) and specificity was 62.5 % (95 % CI: 43.6 – 78.9). Prediction accuracy was 94.4 % (95 % CI: 88.6 – 96 – 1) in differentiating between neoplastic and non-neoplastic lesions. Therefore, magnifying FICE colonoscopy-based SI recommendation was consistent with pathological assessment in 88.3 % of general cases (95 % CI: 82.1 – 92.6) and in 89.7 % (95 % CI: 83 – 94.5) of the high-confidence evaluation cases. The intraobserver agreement value for FICE-based SI predictions was 0.87 (high-confidence evaluations), and the interobserver agreement values were 0.78 (high- and low-confidence evaluations) and 0.82 (high-confidence evaluations) (95 % CI: 0.79 – 0.95). Conclusions FICE-based SI demonstrated 89.7 % concordance with the pathology-based SI.

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Drake, Christopher J., and Charles D. Little. "VEGF and Vascular Fusion: Implications for Normal and Pathological Vessels." Journal of Histochemistry & Cytochemistry 47, no. 11 (November 1999): 1351–55. http://dx.doi.org/10.1177/002215549904701101.

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Vermeulen, A. H., C. Vermeer, and F. T. Bosman. "Histochemical detection of osteocalcin in normal and pathological human bone." Journal of Histochemistry & Cytochemistry 37, no. 10 (October 1989): 1503–8. http://dx.doi.org/10.1177/37.10.2789247.

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We investigated the immunohistochemical localization of osteocalcin in demineralized, paraffin-embedded normal and pathological human bone. Acid decalcification protocols appeared to be more suitable for osteocalcin detection than mild chelating agents. In normal lamellar bone, osteocalcin was detected in osteocytes and along the lamellar bone matrix in fine granular deposits. Under pathological conditions (osteomyelitis, neoplasia), appositional bone showed immunoreactivity in osteoblasts and osteocytes but not in the provisory woven bone matrix. Intense immunoreactivity could be seen at the cell borders of osteoclasts and the bone margins of Howship lacunae. In primary bone-forming tumors, osteocalcin immunoreactivity was detected in osteoblasts and their malignant counterparts. On the basis of these results, we conclude that optimal preservation of osteocalcin is obtained through mild acid decalcifiers. Osteocalcin is deposited in bone matrix, especially that of metabolically inactive bone. In neoplasms, osteocalcin could be a marker of osteoblastic differentiation.

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Banerjee, Somdeb, Di Tran, and Christopher Trevino. "PATH-43. HISTOLOGY OF RADIATION-INDUCED PSEUDOPROGRESSION WITH MULTIPLE FOCI IN TREATED GLIOBLASTOMA." Neuro-Oncology 24, Supplement_7 (November 1, 2022): vii160. http://dx.doi.org/10.1093/neuonc/noac209.616.

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Abstract Radiation induced pseudoprogression (PsP) of brain tumors is defined radiologically as new or enlarging areas of non-tumor magnetic resonance imaging (MRI) contrast enhancement developing within the initial 3-6 months after completing radiation. Distinguishing PsP from genuine tumor progression is of the utmost importance in deciding the clinical course of a patient. Although it is typically diagnosed radiologically, obtaining tissue histopathology can clarify diagnostic uncertainty. However, there is no consensus on defining PsP pathologically. We present the case of a 38-year-old man with a glioblastoma, IDH-wild type, CNS WHO Grade 4 (MGMT promoter methylated) with steroid-refractory PsP, and correlate both radiologic and pathologic features. After initial treatment with a gross total resection and radiation with concurrent temozolomide, he developed a new contrast-enhancing, mass-neutral enhancing lesion consistent with PsP, which did not resolve despite 4 cycles of temozolomide and prolonged steroid treatment. The enhancing lesion was resected, and the pathological examination demonstrated areas of non-pseudopallisading necrosis, numerous macrophages, astrocytosis, hyalinization of blood vessels, and low mitotic activity in the brain parenchyma with residual infiltrative glioma. These features were consistent with radiation-treatment effect and supported a diagnosis of PsP. Over time, varying definitions for PsP include a percentage threshold of treatment effect or necrosis per sample. However, the authors recognize potential sampling bias. Therefore, we recommend including treatment-related effects coupled with the absence of tumor proliferation in the results. These features include fibrinoid necrosis, hyalinization of blood vessels, and eosinophilic coagulation necrosis. From a therapeutic standpoint, it is important to comment on the presence or absence of residual glioma cell proliferation. This case highlights a unique paring of focal histopathology with correlative sections on MRI for pseudoprogression which has not been previously presented.

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Challa, Sundaram, SudhirBabu Karri, MeenaAnga Muthu Kannan, Liza Rajashekhar, and MeghaS Uppin. "Clinico pathological study of adult dermatomyositis: Importance of muscle histology in the diagnosis." Annals of Indian Academy of Neurology 18, no. 2 (2015): 194. http://dx.doi.org/10.4103/0972-2327.150603.

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Babu, R., P. Vittalraj, S. Sundaram, and S. Shalini. "Pathological changes in ureterovesical and ureteropelvic junction obstruction explained by fetal ureter histology." Journal of Pediatric Urology 15, no. 3 (May 2019): 240.e1–240.e7. http://dx.doi.org/10.1016/j.jpurol.2019.02.001.

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Montironi, Rodolfo, Antonio Lopez Beltran, Roberta Mazzucchelli, Liang Cheng, and Marina Scarpelli. "Handling of Radical Prostatectomy Specimens: Total Embedding with Large-Format Histology." International Journal of Breast Cancer 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/932784.

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A problem when handling radical prostatectomy specimens (RPS) is that cancer is often not visible at gross examination, and the tumor extent is always underestimated by the naked eye. The challenge is increased further by the fact that prostate cancer is a notoriously multifocal and heterogeneous tumor. For the pathologist, the safest method to avoid undersampling of cancer is evidently that the entire prostate is submitted. Even though whole mounts of sections from RPS appear not to be superior to sections from standard blocks in detecting adverse pathological features, their use has the great advantage of displaying the architecture of the prostate and the identification and location of tumour nodules more clearly, with particular reference to the index tumour; further, it is easier to compare the pathological findings with those obtained from digital rectal examination (DRE), transrectal ultrasound (TRUS), and prostate biopsies. We are in favour of complete sampling of the RPS examined with the whole mount technique. There are reasons in favour and a few drawbacks. Its implementation does not require an additional amount of work from the technicians’ side. It gives further clinical significance to our work of uropathologists.

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Jang, Bohee, Ayoung Kim, Jisun Hwang, Hyun-Kuk Song, Yunjeon Kim, and Eok-Soo Oh. "Emerging Role of Syndecans in Extracellular Matrix Remodeling in Cancer." Journal of Histochemistry & Cytochemistry 68, no. 12 (July 6, 2020): 863–70. http://dx.doi.org/10.1369/0022155420930112.

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The extracellular matrix (ECM) offers a structural basis for regulating cell functions while also acting as a collection point for bioactive molecules and connective tissue cells. To perform pathological functions under a pathological condition, the involved cells need to regulate the ECM to support their altered functions. This is particularly common in the development of cancer. The ECM has been recognized as a key driver of cancer development and progression, and ECM remodeling occurs at all stages of cancer progression. Thus, cancer cells need to change the ECM to support relevant cell surface adhesion receptor–mediated cell functions. In this context, it is interesting to examine how cancer cells regulate ECM remodeling, which is critical to tumor malignancy and metastatic progression. Here, we review how the cell surface adhesion receptor, syndecan, regulates ECM remodeling as cancer progresses, and explore how this can help us better understand ECM remodeling under these pathological conditions

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Sassi, Farah, Ghada Sahraoui, Lamia Charfi, Zemni Ines, Karima Mrad, and Raoudha Doghri. "A rare case report of a myxoid liposarcoma arising from the broad ligament." Rare Tumors 14 (January 2022): 203636132211488. http://dx.doi.org/10.1177/20363613221148839.

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Myxoid liposarcoma (MLPS) is the second most prevalent subtype of liposarcoma. It is usually found in the deep tissues of the lower limbs and rarely in gynecologic tract. Herein we present the second case in the English literature of a primary MLPS arising from the broad ligament which was thought to be a borderline ovarian tumor. The aim is to discuss its clinical and pathological characteristics. A 42-year-old woman presented with pelvic pain for the last 6 months. Magnetic resonance imaging was not specific. She underwent a surgical resection of the tumor mass, and pathological examination confirmed the diagnosis of MLPS deriving from the broad ligament. She received radiotherapy and the patient is doing well at 3 months follow-up. The clinical aspects, pathological diagnosis, prognosis, and therapy approach of broad ligament MLPS are all poorly understood. Complete surgical resection with or without radiotherapy is the mainstay of treatment in located MLPS.

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Zusman, I., Z. Madar, and A. Nyska. "Individual Variability of Pathological Parameters in Chemically Induced Rat Colon Tumors." Cells Tissues Organs 145, no. 2 (1992): 106–11. http://dx.doi.org/10.1159/000147350.

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Spreafico, Fernanda Servidoni, Cassio Cardoso-Filho, Cesar Cabello, Luis Otávio Sarian, Luiz Carlos Zeferino, and Diama Bhadra Vale. "Breast Cancer in Men: Clinical and Pathological Analysis of 817 Cases." American Journal of Men's Health 14, no. 4 (July 2020): 155798832090810. http://dx.doi.org/10.1177/1557988320908109.

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The objective of the current study was to describe breast cancer cases in men according to age, stage, and histology, calculating risks compared to women. It is a retrospective cross-sectional study of all breast cancer cases of the Hospital Cancer Registry of São Paulo state, Brazil, 2000–2015. Variables were age, sex, stage, and histology. Absolute numbers and proportions, Mann–Whitney test and prevalence ratio with 95% confidence interval were used. The study included 93,737 cases, of which 817 were males. The mean age at diagnosis was 60.3 years in men and 56.2 years in women ( p < .001). Stage II was the most common in both sexes (33.9% in men and 36.5% in women). Men had a higher frequency of stage III than women (PR 1.18, 95% CI 1.01–1.37). Stage 0 was significantly more common in women (PR 0.69, 95% CI 0.51–0.94). Ductal carcinoma and its variants were the most common histological types in both sexes (88.7% in men and 89.0% in women). Men had a higher frequency of rarer histological types such as papillary (PR 2.17, 95% CI 1.36–3.44) and sarcomas (PR 4.10, 95% CI 1.86–9.01). In conclusion, in men, breast cancer diagnosis occurred in more advanced ages and stages. Invasive ductal carcinoma was the primary histological type observed, although rarer types were more frequent.

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Sato, Tetsuhiko, Yasuhiro Otsuka, Yamato Kikkawa, Yoshiko Iwasaki, and Masafumi Fukagawa. "Semiquantitative analysis of virtual histology derived from intravascular ultrasound images at vascular access stenosis." Journal of Vascular Access 20, no. 1_suppl (April 28, 2019): 55–59. http://dx.doi.org/10.1177/1129729818769030.

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Vascular access failure, such as recurrent stenosis and thrombosis, is a major concern in patients with end-stage kidney disease. Neointimal hyperplasia development at the anastomosis site of outflow vessels is a primal cause for recurrent vascular access failure. We previously shed some lights into a role of vitamin D, which exerts a protective effect against neointimal hyperplasia formation. Virtual histology, derived from intravascular ultrasound technology, provides novel insights into plaque composition analysis in atherosclerotic diseases. However, there is so far a lack of evidence on the relation between virtual histology and pathophysiological findings. To elucidate this missing link, we comprehensively reviewed 10 chronic hemodialysis patients who underwent repeated intravascular ultrasound–guided balloon angioplasty. Their age, dialysis vintage, and follow-up period were 75.0 ± 4.24, 20.5 ± 2.12, and 11.5 ± 0.71 (mean ± standard deviation) years, respectively. Pathological cross-sectional analyses were performed using specimens from vascular access surgeries during the follow-up period. Interestingly, positive relation is found between virtual histology–constructed fibrous tissue and pathological neointimal hyperplasia. Strikingly, immunohistological analysis revealed that vitamin D receptor–positive myofibroblasts were abundantly distributed in the equivalent area to virtual histology fibrous tissue. Our 10-year follow-up data of resistant vascular access stenosis indicates strong correlation between vitamin D receptor–rich neointimal vessel hypertrophy and intravascular ultrasound–assisted virtual histological analysis. Intravascular ultrasound technology is one of the minimally invasive diagnostic tools to provide histologically relevant tissue structure information and help determine target vessel stenosis on vascular access.

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Sidhu, Manjinder Singh, Kunal Jain, Sandhya Sood, and Harpreet Kaur. "Localized aggressive angiomyxoma of axilla: A rare case report." Journal of Cancer Research and Therapeutics 19, no. 7 (2023): 2101–3. http://dx.doi.org/10.4103/jcrt.jcrt_2286_21.

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ABSTRACT Aggressive angiomyxoma (AAM) is a rare mesenchymal locally aggressive tumor arising in the pelvis and perineal region in females. On the other hand, extragenital AAMs are extremely rare, specifically in males. We are reporting male AAM which involves only axillary region along with its pathological features. To confirm it, immunohistochemistry (IHC) was done. In sum, pathological examination and IHC aid in distinguishing this lesion and help in differentiating it from other tumors of similar histology. Furthermore, it also aids in planning treatment.

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R Bhuyan, Rashmi. "Vaping Induced Pathological Changes In The Lung Comparing With Imaging Finding-A Case Report Study." Journal of Clinical Studies and Medical Case Reports 5, no. 3 (October 27, 2020): 1–4. http://dx.doi.org/10.24966/csmc-8801/100092.

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Vaping Associated Pulmonary Injury (VAPI) is a group of respiratory symptoms like shortness of breath and tachypnea and, oftentimes, it is associated with non-specific symptoms like generalized fatigue, body ache, fever, nausea, diarrhea, vomiting and chills. This entity has been previously categorized as a diagnosis of exclusion and best described as an exogenous lipoid pneumonia, or chemical pneumonitis. Exogenous lipoid pneumonia has characteristic finding in histology where inhaled fatty substances are recognized with special stain versus endogenous lipoid pneumonia, which is due to airway obstruction giving histology look of cholesterol crystals and accumulated debris. Here we describe the onset of an exogenous cause of lipoid pneumonia in an otherwise healthy patient using cannabis-containing products. We explore, similarities in the clinical case, identify common clinical features, characteristic radiologic findings along with cytological changes in the lungs.

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MacSween, R. N. M. "Pathological Correlation After Cardiac Surgery." Histopathology 20, no. 1 (January 1992): 93–94. http://dx.doi.org/10.1111/j.1365-2559.1992.tb00934.x.

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Campbell, F. "Pancreas – Pathological practice and research." Histopathology 51, no. 5 (November 2007): 708. http://dx.doi.org/10.1111/j.1365-2559.2007.02857.x.

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Matsumoto, Hiroaki, Kazuhiro Nagao, Masahiro Samoto, Junichi Mori, Kosuke Shimizu, Ryo Inoue, Yoshiaki Yamamoto, et al. "Relation between clinicopathological findings and PD-1 or PD-L1 status in non-clear cell renal cell carcinoma by a multicenter study." Journal of Clinical Oncology 37, no. 7_suppl (March 1, 2019): 654. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.654.

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654 Background: We investigated correlation of their pathological findings and their prognostic factors in non-clear cell renal cell carcinoma (ncRCC) diagnosed by both regional pathology (RP) and central pathology (CP) in multicenter study. Methods: In January 2005 to December 2014, 140 cases of ncRCC diagnosed by radical or partial nephrectomy were assessed. We assessed their pathological diagnosis by one central pathologist using the 2016 WHO classification tumor of the kidney. We assessed the correlation between clinical parameters or pathological findings and their prognosis. Then, we performed immunohistochemical analysis using PD-1 related antibody in ncRCC. Results: Median follow up was 32.7 months (1-134). Median age was 66 years, 99 males and 41 females. Pathological stage was pT1a: 58, pT1b: 30, pT2a: 17, pT2b: 6, pT3a: 21, pT3b: 2, pT4: 3 cases, respectively. In RP, histology was papillary (PAP): 60 (42.9%), chromophobe (CHR): 49 (35.0%), containing with sarcomatoid components (SAR): 14 (10.0%) and other histology: 17 (12.1%) cases, respectively. The tumors evaluable by CP were 127 cases, PAP: 52 (40.9%), CHR: 31 (24.4%), SAR: 20 (15.7%) and other histology: 24 cases (18.8%), respectively. The overall concordance rate was 59.5% between RP and CP. In multivariate analysis, SAR was extremely poor prognosis in ncRCC. The high neutrophil lymphocyte ratio (NLR) and at high CRP value were also poor prognostic factors. So, we stratified three risk groups using three factors, namely NLR, CRP and SAR. In overall survival, there were significant prognostic differences within three groups (p = 0.0014). In immunohistochemistry, PD-1 or PD-L1 expression correlated with poor overall, cancer specific and recurrence free survival in ncRCC. In multivariate analysis, PD-L1 expression was most significant prognostic factor for ncRCC. Conclusions: These results suggest that Risk stratification by three risk factors is useful prognostic model and the expression of PD-1 and PD-L1 may be a useful prognostic factor in ncRCC.

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Maleszewski, Joseph J. "Cardiac amyloidosis: a clinical and pathological review." Diagnostic Histopathology 28, no. 4 (April 2022): 181–90. http://dx.doi.org/10.1016/j.mpdhp.2022.02.001.

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Moore, Michelle, Gregory Y. Lauwers, and M. Priyanthi Kumarasinghe. "Challenges in pathological assessment of endoscopic resections." Diagnostic Histopathology 26, no. 1 (January 2020): 15–21. http://dx.doi.org/10.1016/j.mpdhp.2019.10.008.

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Compérat, Eva. "Pathological and molecular aspects of urothelial carcinomas." Diagnostic Histopathology 26, no. 7 (July 2020): 330–36. http://dx.doi.org/10.1016/j.mpdhp.2020.04.004.

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Laule, Cornelia, Irene M. Vavasour, Esther Leung, David KB Li, Piotr Kozlowski, Anthony L. Traboulsee, Joel Oger, Alex L. MacKay, and GR Wayne Moore. "Pathological basis of diffusely abnormal white matter: insights from magnetic resonance imaging and histology." Multiple Sclerosis Journal 17, no. 2 (October 21, 2010): 144–50. http://dx.doi.org/10.1177/1352458510384008.

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Background: The pathological basis of diffusely abnormal white matter (DAWM) in multiple sclerosis (MS) has not been elucidated in detail, but may be an important element in disability and clinical progression. Methods: Fifty-three subjects with MS were examined with T1, multi-echo T2 and magnetization transfer (MT). Twenty-three samples of formalin-fixed MS brain tissue were examined with multi-echo T2 and subsequently stained for myelin phospholipids using luxol fast blue, for axons using Bielschowsky, immunohistochemically for the myelin proteins myelin basic protein (MBP) and 2′,3′-cyclic nucleotide 3′ phosphohydrolase (CNP) and for astrocytes using glial fibrillary acidic protein (GFAP). Regions of interest in DAWM were compared with normal appearing white matter. Results: Fourteen of 53 subjects with MS in the in vivo study showed the presence of DAWM. Subjects with DAWM were found to have a significantly lower Expanded Disability Status Scale (EDSS) and shorter disease duration (DD) when compared with subjects without DAWM (EDSS: 1.5 versus 3.0, p = 0.031; DD: 5.4 versus 10.3 years, p = 0.045). DAWM in vivo had reduced myelin water and MT ratio, and increased T2 and water content. Histological analysis suggests DAWM, which shows a reduction of the myelin water fraction, is characterized by selective reduction of myelin phospholipids, but with a relative preservation of myelin proteins and axons. Conclusions: These findings suggest that the primary abnormality in DAWM is a reduction or perturbation of myelin phospholipids that correlates with a reduction of the myelin water fraction.

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Sugandhi, N., S. Agarwala, V. Bhatnagar, M. K. Singh, and R. Sharma. "Liver histology in choledochal cyst- pathological changes and response to surgery: the overlooked aspect?" Pediatric Surgery International 30, no. 2 (December 27, 2013): 205–11. http://dx.doi.org/10.1007/s00383-013-3453-y.

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Journal articles on the topic 'Histology, Pathological'

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