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Dissertations / Theses on the topic 'Histone acetylation in brain cells'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Clayton, Alison Louise. "Core histone acetylation of active genes." Thesis, University of Portsmouth, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240358.

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2

Crosato, Milena. "Characterization of histone acetylation in butyrate-resistant HeLa cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0033/MQ64337.pdf.

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3

Crosato, Milena. "Characterization of histone acetylation in butyrate-resistant HeLa cells." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30361.

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Butyrate is a short chained fatty acid that induces histone hyperacetylation by inhibiting histone deacetylases. This hyperacetylation of histones then leads to a change in chromatin conformation and transcription of genes. Histone deacetylases have recently been found to directly affect gene expression by associating with transcriptional repressor complexes. The present thesis describes the initial characterization of histone deacetylase activity in variants of HeLa cells that are capable of growth in cytotoxic concentrations of butyrate. Analysis of acetylation levels of total histones by tr

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4

Yildirim, Ferah [Verfasser]. "Involvement of histone acetylation in neuroprotection against brain ischemic injury / Ferah Yildirim." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2010. http://d-nb.info/1024502422/34.

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5

VIANELLO, ELEONORA. "In vivo evaluation of biomolecular mechanisms of bilirubin toxicity and pre-clinical therapies." Doctoral thesis, Università degli Studi di Trieste, 2017. http://hdl.handle.net/11368/2908155.

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Introduction. Neonatal jaundice is a common and benign condition usually resolved during the first week of life. Neonates with very high level of unconjugated bilirubin (UCB), with an increase of the free bilirubin (Bf), may develop encephalopathy, with different grade of severity. Typical symptoms include motor disorder, auditory dysfunction, memory and learning deficits, reflecting selective damage respectively for cerebellum and basal ganglia, inferior colliculus, and hippocampus. Several studies reported that bilirubin may activate signal cascades that culminate to cell survival or death,

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6

Pourian, Ali. "The effect of valproic acid on histone acetylation in FaDu-luc head and neck squamous cell carcinoma cells." Thesis, University of Iowa, 2011. https://ir.uiowa.edu/etd/1256.

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7

Ene, Chibawanye Isidore. "Relevance of histone 3 lysine 27 modifiers in neural stem cells and malignant brain tumours." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610540.

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8

Khilji, Saadia. "Dissecting the Epigenetic Signaling Underlying Early Myogenic Differentiation." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42092.

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9

Bressan, Raul Bardini. "Genome editing as a tool to explore transcriptional and epigenetic regulation in neural stem cells and brain cancer." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31095.

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Mammalian neural stem cell (NSC) lines provide a useful experimental model for basic and applied research across stem cell and developmental biology, regenerative medicine and neuroscience. NSCs are clonally expandable, genetically stable, and easily transfectable - experimental attributes compatible with functional genetic analyses. However, targeted genetic manipulations have not been reported for mammalian NSC lines. Here, we deploy the CRISPR/Cas9 technology and demonstrate a variety of diverse targeted genetic modifications in both mouse and human NSC lines such as: targeted transgene ins

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10

Guimarães, Douglas Magno. "Uso de inibidores de Histona Deacetilase como estratégia terapêutica para sensibilizar células-tronco tumorais a quimioterapia: uma nova visão terapêutica sobre carcinomas mucoepidermoide bucais." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-21092015-164942/.

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Carcinoma mucoepidermóide (CME) é o tumor maligno de glândulas salivares mais comum, representando cerca de 30% dos tumores malignos. O tratamento do CME é a ressecção cirúrgica com eventual radioterapia. Assim, o tratamento do CME pode levar a varias complicações estéticas e funcionais. A quimioterapia tem sido utilizadas apenas em casos recorrentes ou com metástases à distancia. Vários relatos na literatura tem mostrado que o tratamento com drogas isoladas ou combinadas possuem uma resposta insatisfatória e de curta duração em grande parte devido a aquisição de resistência a quimioterapia. R

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11

Stillman, Anthony D. "Targeting Sphingosine Kinase 2 as a Treatment for Cholangiocarcinoma." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/6067.

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Cholangiocarcinoma (CCA) has a high mortality rate and its occurrence is rising. This increase prompts the need for improved CCA treatments. Studies have suggested that CCA is highly reliant on the sphingosine-1-phosphate-receptor-2 (S1PR2) and sphingosine kinase 2 (SphK2). Recently, a competitive SphK2 inhibitor, ABC294640, has been approved for clinical trial. ABC294640 has the potential to treat CCA, which is support by a phase I clinical study that was able to temporarily treat a patient suffering from metastasized CCA with ABC294640. To determine the viability of ABC294640 as a treatment

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12

Murray, Elaine K. "The role of histone acetylation in sexual differentiation of the mouse brain." 2010. https://scholarworks.umass.edu/dissertations/AAI3409827.

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Sex differences are widespread throughout the nervous system and have been identified in relation to almost every neural characteristic, from basic anatomy, to behavior, to differences in the prevalence of neuropathology. Most sex differences arise following exposure to the steroid hormone, testosterone, but relatively little is known about the molecular mechanism of steroid hormone action. In many cases, perinatal hormone exposure determines life-long sex specific changes, suggesting a long-lasting cellular memory for the testosterone exposure. Testosterone-induced changes in chromatin struct

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13

McDonnell, Eoin. "The Role of Acetylation in the Metabolic Reprogramming of Cancer Cells." Diss., 2016. http://hdl.handle.net/10161/13387.

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<p>Identifying metabolic vulnerabilities of cancer cells remains a subject of investigation for the identification of potential metabolically based therapies for cancer. It is well known that proliferating cells become largely dependent on glucose and glutamine for their growth. Interestingly, we find that lipid oxidizing genes are consistently downregulated across a wide variety of cancers while lipid synthesizing genes are elevated. This indicates that lipid oxidation may be refractory to cancer cell growth. Studies have shown beneficial effects of carbohydrate restriction in various forms i

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14

Darwish, Manar M. "Investigating the Role of Lactate in Regulating Gene Expression through Epigenetic Modifications in Neuronal Cells." Diss., 2019. http://hdl.handle.net/10754/663537.

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Lactate has been long thought of as a dead-end waste product of glycolysis. In the brain, recent evidence has revealed a key role of L-lactate creating a paradigm-shift in our understanding of the neuronal energy metabolism. The Astrocyte neuron lactate shuttle (ANLS) model, has shown L-Lactate as the main energy substrate delivered by astrocytes to neurons to sustain neuronal oxidative metabolism. This metabolic coupling is an essential mechanism for long-term memory formation. Experimental evidence indicates that the role of lactate in cognitive function is not limited to being a neuro

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15

Hsu, Bo-Ting, and 許博婷. "Interaction of nervous necrosis virus coat protein with histone H3.3 in grouper brain cells." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/pz7h9v.

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碩士<br>國立臺灣大學<br>漁業科學研究所<br>105<br>Nervous necrosis virus (NNV), a piscine betanodavirus, is the causing agent of viral nervous necrosis and viral encephalopathy and retinopathy in larvae and juveniles of a wide range of marine teleost species. The mechanism of NNV infection was investigated using a virus overlay protein binding assay (VOPBA), which resulted in the identification of a nuclear protein, histone H3.3, from grouper brain cells. The histone H3.3 is the variant of histone H3 which gets together with H2A, H2B and H4 to form a histone octamer for DNA wrapped binding in nucleosome. The

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