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Dissertations / Theses on the topic 'Histone acetylation'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Choi, Jennifer Kristel. ""Open" chromatin : histone acetylation, linker histones & histone variants." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45271.

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2

Man, Pui-sum Ellen. "Histone acetylation in gynaecological malignancies." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31972068.

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3

Cervoni, Nadia. "DNA demethylation and histone acetylation." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38166.

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Unlike in somatic cells, cancer cells adopt an aberrant pattern of methylation as well as histone acetylation, and therefore distort the chromatin structure. Chapters 2--4 of this thesis look at mechanisms carried out by the recently cloned DNA demethylase, how its demethylation activity is closely linked with the semblance of acetylation of chromatin, and how this relationship can be skewed in cancer. The three intriguing mechanisms described provide attractive models by which to explain general genome wide demethylation, site specific demethylation of genes upon their activation, and the rel

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4

Man, Pui-sum Ellen, and 萬佩心. "Histone acetylation in gynaecological malignancies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31972068.

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5

Venkataraman, Shanmugasundaram. "Histone acetylation and nucleosome dynamics." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/23234.

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In this report, I will describe purification of core histone octamers from chicken blood, HeLa nuclei and yeast cells, along with preparation of DNA fragments containing the 208 bp 5S rDNA gene and the adult beta (b<sup>A</sup>)-globin gene promoter. <i>In vitro</i> experiments studying the effect of histone acetylation on the positioning and mobility of nucleosomes on the sea urchin 5S rDNA gene and the chicken b<sup>A</sup>-globin gene promoter will be described. The former provides a well studied nucleosome positioning and mobility model system, while the latter is a developmentally regulat

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6

Hebbes, T. R. "Histone acetylation and transcriptionally active chromatin." Thesis, University of Portsmouth, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382541.

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7

Clayton, Alison Louise. "Core histone acetylation of active genes." Thesis, University of Portsmouth, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240358.

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8

Choudhury, Mahua Shukla Shivendra D. "Alcohol induced histone acetylation mediated by histone acetyl transferase GCN5 in liver." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6866.

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The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on April 6, 2010). Vita. Thesis advisor: Shivendra D. Shukla. "August 2008" Includes bibliographical references

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9

Ou, Jing Ni. "Epigenetic crosstalk between DNA demethylation and histone acetylation." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32413.

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Abnormal methylation patterns such as regional hypermethylation and genomic hypomethylation often result in transcriptional changes of critical genes that are central to the progression of human cancers. It is therefore important to identify the mechanisms that are responsible for the alterations in order to identify proper pharmacological targets. This thesis examines whether specific cellular factors are involved in establishing the state of DNA hypomethylation in cancer cells and whether changes in chr

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10

Smith, Anna Elizabeth. "The role of histone acetylation in recognition memory." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715770.

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11

Jin, Yi. "Genetic and genomic studies of histone H3 methylation and acetylation." Pullman, Wash. : Washington State University, 2008. http://www.dissertations.wsu.edu/Dissertations/Fall2008/Y_Jin_120108.pdf.

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12

Pourhanifeh-Lemeri, Roghayeh. "Identification of Non-histone Acetylation Targets in Saccharomyces cerevisiae." Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22885.

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Lysine acetylation is a conserved post-translational modification (PTM) which was traditionally believed to be limited to histones and the regulation of gene expression. However, recent proteomic studies have identified lysine acetylation on proteins implicated in virtually all cellular processes indicating that this PTM plays a global regulatory role. Indeed, in humans, aberrance of lysine acetyltransferase (KAT) activity is associated with various pathogenesis. To date, over 2500 human proteins are known to be acetylated in vivo, but very few acetylations have been linked to specific KATs. H

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13

Crosato, Milena. "Characterization of histone acetylation in butyrate-resistant HeLa cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0033/MQ64337.pdf.

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14

Crosato, Milena. "Characterization of histone acetylation in butyrate-resistant HeLa cells." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30361.

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Butyrate is a short chained fatty acid that induces histone hyperacetylation by inhibiting histone deacetylases. This hyperacetylation of histones then leads to a change in chromatin conformation and transcription of genes. Histone deacetylases have recently been found to directly affect gene expression by associating with transcriptional repressor complexes. The present thesis describes the initial characterization of histone deacetylase activity in variants of HeLa cells that are capable of growth in cytotoxic concentrations of butyrate. Analysis of acetylation levels of total histones by tr

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15

Tsaprouni, Loukia G. "Histone acetylation and inflammatory mediators in inflammatory bowel disease." Thesis, University of Bedfordshire, 2003. http://hdl.handle.net/10547/620761.

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During cell activation the tightly compacted DNA is made available to DNA-binding proteins allowing the induction of gene transcription. In the resting cell, DNA is packaged into chromatin whose fundamental subunit is the nucleosome, composed of an octamer of four core histones (H) 3, 4, 2A and 2B. During the induction of gene transcription, modification of histones, by acetylation, methylation etc., results in unwinding of the DNA, permitting access of large DNAbinding proteins, such as RNA polymerase II, and subsequent induction of gene transcription. This investigation initially examined th

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16

Carey, Krystle Lea. "The search for small molecule inhibitors of histone acetylation." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/173969/.

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Histone acetylation is a key mechanism of transcriptional regulation, which is mediated by two sets of enzymes; HATs and HDACs. Under normal physiological circumstances there is an orchestrated balance between the actions of HATs and HDACs. Disruption of this balance can lead to a number of cellular events which can cause the onset of various diseases for example cancer and HIV. The search for small molecule inhibitors of histone acetylation focuses on anacardic acid and the azumamides. Anacardic acid is a natural compound found in cashew nut shell liquid. Its structure consists of salicylic a

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17

Hammond, Colin. "The structural analysis of histone H3 lysine 56 acetylation and related histone chaperone complexes." Thesis, University of Dundee, 2013. https://discovery.dundee.ac.uk/en/studentTheses/2e55b2c4-4821-4961-b4bb-eae1b24a446e.

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18

Sherman, Robyn. "Regulation of Histone H3 Proteolysis by Acetylation in Tetrahymena thermophila." Scholarship @ Claremont, 2015. http://scholarship.claremont.edu/scripps_theses/598.

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Chromatin is the combination of DNA and proteins in the nucleus that is used to aid in the compaction of DNA. Histones are a group of proteins used to condense DNA by forming a complex (nucleosome) around which DNA wraps around; there are two of each type of histone in a nucleosome: H2A, H2B, H3 and H4. Once the DNA is wrapped around the histones, the genome is further compacted. A shortened, "clipped" version of histone H3 has been found in some organisms including yeasts, flies, mammalian stem cells, and the ciliated protozoan, Tetrahymena thermophila. In each organism, clipping occurs at a

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19

Siriaco, Giorgia. "Relationship between histone acetylation and the transcriptional activity of genes." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/12953.

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20

Naiyachit, Yanin. "Global analysis of histone variant H2A.Z acetylation in Saccharomyces cerevisiae." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/global-analysis-of-histone-variant-h2az-acetylation-in-saccharomyces-cerevisiae(47129712-8f67-427f-bb7a-50e4e91260db).html.

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The histone variant H2A.Z is an evolutionarily conserved variant which is an essential chromatin component for many organisms. H2A.Z plays a pivotal role in a diverse array of chromatin-based processes such as gene transcription and chromosome segregation. In yeast, H2A.Z is acetylated at four N-terminal lysine residues (K3, K8, K10 and K14). Previous studies have shown that these acetylation sites are critical for H2A.Z function. My research aim was to examine how these four acetylatable lysines act to regulate the function of H2A.Z. Genome mapping of the acetylated K8, K10, K14 isoforms reve

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21

Taylor, Gillian Catherine Agnes. "H4K16 acetylation during embryonic stem cell differentiation." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8069.

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Eukaryote DNA is organised into the more compact nucleosome by wrapping 147bp of DNA around a histone octamer core. The N-terminal tails of the histones protrude through the DNA and can be modified by a variety of enzymes. Acetylation of Histone 4 Lysine 16 (H4K16ac) is an important modification associated with an increase in transcription, and in flies is an important component of the doseage compensation system. It is also unique amongst histone modifications in that it has been directly associated with chromatin decompaction. H4K16ac has been linked to development through its Histone Acetyl

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22

Ladipo, Paul B. "The effects of histone acetylation on the maize allele PL1-blotched." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5038.

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Thesis (M.A.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on September 29, 2008) Includes bibliographical references.

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23

Orr, Jenny Alexandra. "Chromatin phenotype and the role of histone acetylation in prostate cancer." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426718.

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24

Yau, Peter Mo-Ping. "Structural analysis of the nucleosome and the effects of histone acetylation." Thesis, Liverpool John Moores University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261657.

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25

Manohar, Mridula. "Chemically Modified Histone H3 to Study Acetylation at the Nucleosome Dyad." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1243525554.

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26

Agudelo, Garcia Paula A. "Identification of New Roles for Histone Acetyltransferase 1." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492599746298382.

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27

Qin, Song. "Acetylation of histone n-terminal tails contributes to DNA double strand break repair." The Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=osu1134575402.

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28

Randall, Tamzin Ellen. "The role of histone acetylation in the imprinted expression of IGF2-H19." Thesis, University of Birmingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270059.

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29

Rose, Sally Louisa. "Phosphorylation and acetylation of histone H3 concomitant with immediate early gene induction." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251624.

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30

Greenberger, Benjamin A. "Combined Effect of Histone Acetylation and Acetyl Mark Readers on Radiation Sensitivity." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:27007761.

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We are interested in studying potential drugs that have the ability to make tumors more sensitive to radiation. There has been much interest in examining the effect of modulation to chromatin structure on the DNA damage response (DDR). We therefore examined histone deacetylase (HDAC) inhibitors, small molecules that modify the structural features of chromatin involved in the packaging of DNA. HDAC inhibitors are considered to be potential drug candidates to complement radiation therapy, yet the mechanisms underlying their effects have been elusive. To study the DDR signaling effects of HDAC i

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31

Yildirim, Ferah [Verfasser]. "Involvement of histone acetylation in neuroprotection against brain ischemic injury / Ferah Yildirim." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2010. http://d-nb.info/1024502422/34.

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32

Hamed, Munerah. "Effect of p300 HAT Activity on Myogenic Differentiation." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23707.

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Skeletal muscle specification and differentiation programs are regulated by the myogenic regulatory factors which include Myf5, MyoD, myogenin and Mrf4. Upstream of the MRFs, the transcription co-activators and other intracellular and extracellular signals play crucial roles in regulating skeletal myogenesis. Histone acetyltransferase activity of p300 is required for Myf5 and MyoD expression. Furthermore, the MyoD core enhancer region is indispensable for MyoD expression. However, the mechanism by which p300 activates MyoD gene expression is to be determined. The histone acetyltransferase acti

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33

Danilenko, Nataliya [Verfasser]. "Structural basis for histone H3 acetylation by Rtt109 in complex with histone chaperones Asf1 and Vps75 / Nataliya Danilenko." Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2020. http://d-nb.info/1209268515/34.

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34

Tuttle, Camilla Susannah Laura. "The expression of HAT and HDAC enzymes in asthma airways." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/62873/1/Camilla_Tuttle_Thesis.pdf.

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Asthma is chronic inflammatory disease of the lower airways that is both, genetically inherited and environmentally influenced. This project investigated how molecular mechanisms known to be influenced both genetically and environmentally, contribute to the onset of asthma.

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35

Wu, Jheng-Yu. "Regulation of Extracellular Signal-Regulated Kinase by Histone Deacetylase 6." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6985.

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Extracellular signal-regulated kinases 1/2 (ERK1/2) are important kinases regulating cell proliferation and cell migration, and have been established as therapeutic targets for cancer treatment. Previously, we found that ERK1 phosphorylates histone deacetylase 6 (HDAC6) to regulate its enzymatic activity. However, whether HDAC6 reciprocally modulates ERK1 activity is unknown. Here, we have discovered that ERK1/2 are acetylated proteins and shown that HDAC6 manipulates ERK1’s kinase activity via deacetylation. We demonstrated that both ERK1 and ERK2 interact with HDAC6 physically. We showed tha

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36

Tong, Kevin. "Characterization of the Schizosaccharomyces Pombe Hat1 Complex: the Role of Histone H4 Acetylation in Telomeric Silencing." Thesis, Boston College, 2009. http://hdl.handle.net/2345/2222.

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Thesis advisor: Anthony T. Annunziato<br>Thesis advisor: Charles Hoffman<br>The Hat1 complex was characterized in S. pombe. Through tandem affinity purification and mass spectrometry, it was determined that Hat1 is associated with Mis16 (an orthologue of HAT2). Unlike HAT2 in S. cerevisiae, we confirm mis16 to be an essential gene in S. pombe. As expected, the S. pombe Hat1 complex was found to acetylate lysines 5 and 12 of histone H4. In contrast to budding yeast, deletion of hat1 alone resulted in the loss of telomeric silencing without concomitant mutations of the H3 N-terminal domain. Dele

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37

Alzoubi, Samer. "Histone acetylation and chemoresistance in colorectal cancer : an opportunity for effective personalized treatment." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11581.

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Colorectal cancer (CRC) is the most common cause of deaths in the West. Despite many therapeutic opportunities, drug resistance or recurrence has significant rates among patients. Nearly 50% of CRC patients develop metastases. Therefore, sensitive biomarker and effective treatments with minimal toxicity are needed. Genetic and epigenetic alterations play major roles in initiation, development, and chemoresistance of CRC. Histone deacetylase2 (HDAC2) over-expression is well-known in CRC. Many studies have associated HDAC2 over-expression and TP53 mutations with late stages of metastatic CRC (mC

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38

Dobosy, Joseph R. "Involvement of histone deacetylases in DNA methylation in Neurospora crassa, and characterization of four other histone acetylation associated genes /." view abstract or download file of text, 2003. http://wwwlib.umi.com/cr/uoregon/fullcit?p3102161.

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Thesis (Ph. D.)--University of Oregon, 2003.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 91-96). Also available for download via the World Wide Web; free to University of Oregon users.

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39

Chen, Chang-Shi. "Beyond induction of histone acetylation the multi-facets of the antineoplastic effect of HDAC inhibitors /." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164649581.

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40

Lim, Sean. "The Relationship Between Metabolic Circumstance and Epigenetic Acetylation in Myoblast Fate and Function." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42659.

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Muscle tissue is grown and maintained by muscle stem cells termed satellite cells. Activated satellite cells become myoblasts, which must proliferate then differentiate into functional muscle. This process, known as myogenesis, is controlled by a cascade of epigenetic regulatory events. One facet of this regulation is histone acetylation, which can be influenced by the availability of metabolites within a cell. In this study, the ability of glucose, pyruvate, or glutamine to change histone acetylation levels in cultured myoblasts was investigated. Changing concentrations of glucose or pyruvate

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41

Politis, Panagiotis K. "The role of chromatin in the regulation of PHO5 and PHO3 genes in Saccharomyces cerevisiae." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343632.

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42

Basford, Joshua E. "Colinear Expression of the Mouse HoxB Cluster: Potential Regulatory Role of Histone H4 Acetylation." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin997988435.

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43

Juliano, Camila Nóbrega. "Avaliação do padrão de acetilação das histonas por técnica imunohistoquímica em adenocarcinoma de pâncreas : influência epigenética na carcinogenese." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/40121.

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Introdução: O Adenocarcinoma ductal pancreático é um tumor bastante agressivo que apresenta uma alta de letalidade e, para o qual, poucas opções terapêuticas estão disponíveis. Isto pode ser parcialmente explicado pela complexidade derivada de múltiplas aberrações genéticas e da população celular mista presente em um tumor pancreático, o que também pode explicar o curso clínico heterogêneo observado na prática diária. Ultimamente, pesquisas científicas têm contribuído para ampliar o conhecimento sobre o impacto das alterações epigenéticas no desenvolvimento de múltiplos tipos de câncer, porém

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44

Eisenstatt, Jessica R. "Histone H4 Acetylation in the DNA Damage Response and Telomere Formation of Schizosaccharomyces pombe." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1440417554.

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45

Wettermark, Anna. "Histone modifications and their role in splicing." Thesis, Linköpings universitet, Biologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166639.

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Splicing is the process when introns gets removed and exons are spliced together. This is an important step to form a clean mRNA with no unnecessary sequences that could interrupt protein synthesis. There are different types of splicing and some of them need a complex called spliceosome. The spliceosome requires ATP, small nuclear RNAs and splicing factors. The spliceosome and the process splicing can be regulated by epigenetics, and one epigenetic mechanism is histone modification. There are four types of histone modifications; methylation, phosphorylation, ubiquitination and acetylation. The

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46

Ge, Zhongqi. "Role of Nuclear Hat1p Complex and Acetylation of Newly Synthesized Histone H4 in Chromatin Assembly." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1356622980.

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47

Rahman, Sunniyat. "Molecular mechanisms and outcomes of arsenic-induced histone acetylation and microRNA regulation in cellular transformation." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/30712.

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Chronic exposure to arsenic causes negative health outcomes, particularly malignant neoplasms of the skin, lung and bladder. Although epidemiological data has associated arsenic exposure to cancer, a clear molecular mechanism has remained elusive. This thesis studied the impact of arsenic trioxide (ATO) exposure on histone acetylation and microRNA expression at both tolerated and toxic levels in vitro to determine an epigenetic-based mechanism of carcinogenesis. This thesis outlines a framework for identifying tolerated and toxic ATO exposures, as a prerequisite to epigenetic characterisation.

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48

Crump, Nicholas T. "The role of p300/CBP in dynamic acetylation of histone H3K4me3 and immediate-early gene regulation." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534164.

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49

Kruhlak, Michael John. "Sub-nuclear distribution and mobility of nuclear proteins involved in histone acetylation and pre-mRNA splicing." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ64821.pdf.

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50

Shukla, Abhijit. "HISTONE POSTTRANSLATIONAL MODIFICATIONS AND GENE EXPRESSION IN SACCHAROMYCES CEREVISIAE." Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1967969411&sid=3&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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Thesis (Ph. D.)--Southern Illinois University Carbondale, 2009.<br>"Department of Molecular Biology, Microbiology and Biochemistry." Includes bibliographical references (p. 131-155). Also available online.

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