Relevant bibliographies by topics / Histone post-translational modifications (hPTMs)

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Academic literature on the topic 'Histone post-translational modifications (hPTMs)'

Author: Grafiati
Published: 9 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "Histone post-translational modifications (hPTMs)"

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Hu, Qiwen, Casey S. Greene, and Elizabeth A. Heller. "Specific histone modifications associate with alternative exon selection during mammalian development." Nucleic Acids Research 48, no. 9 (2020): 4709–24. http://dx.doi.org/10.1093/nar/gkaa248.

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Abstract Alternative splicing (AS) is frequent during early mouse embryonic development. Specific histone post-translational modifications (hPTMs) have been shown to regulate exon splicing by either directly recruiting splice machinery or indirectly modulating transcriptional elongation. In this study, we hypothesized that hPTMs regulate expression of alternatively spliced genes for specific processes during differentiation. To address this notion, we applied an innovative machine learning approach to relate global hPTM enrichment to AS regulation during mammalian tissue development. We found
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Andonegui-Elguera, Marco A., Rodrigo E. Cáceres-Gutiérrez, Alejandro López-Saavedra, et al. "The Roles of Histone Post-Translational Modifications in the Formation and Function of a Mitotic Chromosome." International Journal of Molecular Sciences 23, no. 15 (2022): 8704. http://dx.doi.org/10.3390/ijms23158704.

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During mitosis, many cellular structures are organized to segregate the replicated genome to the daughter cells. Chromatin is condensed to shape a mitotic chromosome. A multiprotein complex known as kinetochore is organized on a specific region of each chromosome, the centromere, which is defined by the presence of a histone H3 variant called CENP-A. The cytoskeleton is re-arranged to give rise to the mitotic spindle that binds to kinetochores and leads to the movement of chromosomes. How chromatin regulates different activities during mitosis is not well known. The role of histone post-transl
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Ghiani, Lavinia, and Susanna Chiocca. "High Risk-Human Papillomavirus in HNSCC: Present and Future Challenges for Epigenetic Therapies." International Journal of Molecular Sciences 23, no. 7 (2022): 3483. http://dx.doi.org/10.3390/ijms23073483.

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Head and Neck Squamous Cell Carcinoma (HNSCC) is a highly heterogeneous group of tumors characterized by an incidence of 650,000 new cases and 350,000 deaths per year worldwide and a male to female ratio of 3:1. The main risk factors are alcohol and tobacco consumption and Human Papillomavirus (HPV) infections. HNSCC cases are divided into two subgroups, the HPV-negative (HPV−) and the HPV-positive (HPV+) which have different clinicopathological and molecular profiles. However, patients are still treated with the same therapeutic regimens. It is thus of utmost importance to characterize the mo
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Tibana, Ramires, Octávio Franco, Rinaldo Pereira, James Navalta, and Jonato Prestes. "Exercise as an Effective Transgenerational Strategy to Overcome Metabolic Syndrome in the Future Generation: Are We There?" Experimental and Clinical Endocrinology & Diabetes 125, no. 06 (2017): 347–52. http://dx.doi.org/10.1055/s-0042-120538.

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AbstractMetabolic syndrome (MetS) consist in a combination of cardiovascular risk factors including elevated blood pressure, dyslipidemia, insulin resistance, hyperglycemia and abdominal obesity. Exercise performed before, during and after pregnancy can exert positive effects to counteract MetS risk factors. Here this review aims to analyze the effects of exercise performed before (fathers and mothers) and after periconception (mothers) by using experimental models and its effects on MetS risk factors in offspring. All selected studies investigated the effects of aerobic exercise before, durin
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Agnusdei, Angelo, Adrián González-García, Donato Gerin, et al. "Histone Methyltransferases AcDot1 and AcRmtA Are Involved in Growth Regulation, Secondary Metabolism, and Stress Response in Aspergillus carbonarius." Toxins 17, no. 4 (2025): 196. https://doi.org/10.3390/toxins17040196.

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Histone post-translational modifications (HPTMs) can affect gene expression by rearranging chromatin structure. Between these, histone methylation is one of the most studied in filamentous fungi, and different conserved domains coding for methyltransferase were found in Aspergillus spp. genomes. In this work, the role of the histone methyltransferases AcDot1 and AcRmtA in the mycotoxigenic fungus Aspergillus carbonarius was investigated, obtaining knockout or overexpression mutants through Agrobacterium tumefaciens-mediated transformation (ATMT). A. carbonarius is responsible for grape-bunch r
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Gaona-López, Carlos, Lenci K. Vazquez-Jimenez, Alonzo Gonzalez-Gonzalez, et al. "Advances in Protozoan Epigenetic Targets and Their Inhibitors for the Development of New Potential Drugs." Pharmaceuticals 16, no. 4 (2023): 543. http://dx.doi.org/10.3390/ph16040543.

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Protozoan parasite diseases cause significant mortality and morbidity worldwide. Factors such as climate change, extreme poverty, migration, and a lack of life opportunities lead to the propagation of diseases classified as tropical or non-endemic. Although there are several drugs to combat parasitic diseases, strains resistant to routinely used drugs have been reported. In addition, many first-line drugs have adverse effects ranging from mild to severe, including potential carcinogenic effects. Therefore, new lead compounds are needed to combat these parasites. Although little has been studie
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Taylor, Bethany C., and Nicolas L. Young. "Combinations of histone post-translational modifications." Biochemical Journal 478, no. 3 (2021): 511–32. http://dx.doi.org/10.1042/bcj20200170.

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Histones are essential proteins that package the eukaryotic genome into its physiological state of nucleosomes, chromatin, and chromosomes. Post-translational modifications (PTMs) of histones are crucial to both the dynamic and persistent regulation of the genome. Histone PTMs store and convey complex signals about the state of the genome. This is often achieved by multiple variable PTM sites, occupied or unoccupied, on the same histone molecule or nucleosome functioning in concert. These mechanisms are supported by the structures of ‘readers’ that transduce the signal from the presence or abs
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Hattori, Takamitsu, Joseph M. Taft, Kalina M. Swist, et al. "Recombinant antibodies to histone post-translational modifications." Nature Methods 10, no. 10 (2013): 992–95. http://dx.doi.org/10.1038/nmeth.2605.

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Fan, Jing, Kimberly A. Krautkramer, Jessica L. Feldman, and John M. Denu. "Metabolic Regulation of Histone Post-Translational Modifications." ACS Chemical Biology 10, no. 1 (2015): 95–108. http://dx.doi.org/10.1021/cb500846u.

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Abaturov, O. E., and A. O. Nikulina. "Post-translational histone modifications associated with the development of metabolic dysfunction-associated fatty liver disease. Part 1. General provisions." GASTROENTEROLOGY 58, no. 3 (2024): 210–21. http://dx.doi.org/10.22141/2308-2097.58.3.2024.626.

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Based on the analysis of literary sources of PubMed, MedLine, The Cochrane Library, EMBASE database, the authors of the article give general provisions regarding post-translational modifications of histones (small proteins with a molecular weight of 10–15 kDa, which make up the largest part of nuclear proteins), which are associated with the development of metabolic dysfunction-associated fatty liver disease. The authors emphasize that post-translational histone modifications regulate the activity of gene expression, and each of these types differently changes the structure of chromatin and, a
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Dissertations / Theses on the topic "Histone post-translational modifications (hPTMs)"

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GHIANI, LAVINIA. "THE HISTONE POST-TRANSLATIONAL MODIFICATION LANDSCAPE IN HPV+ AND HPV- HEAD AND NECK SQUAMOUS CELL CARCINOMA: CHARACTERIZING THE ONCOGENIC ROLE OF THE H3K36ME2 METHYLTRANSFERASE NSD2." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/820678.

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Background: HNSCC is a heterogeneous group of tumors caused mainly by environmental factors and human papillomavirus (HPV) infections. HPV- and HPV+ HNSCC are considered distinct entities, however, they are still treated with the same therapeutic strategies. HPV-induced tumorigenesis is mainly mediated by the E6/E7 oncoviral proteins, that, among all, alter the epigenetics of the host cells. Nevertheless, epigenetic profiles of HNSCC subtypes have not been clearly profiled. Results and Conclusion: hPTMs super-SILAC analysis of HNSCC cell lines and patients’ tissue samples revealed signific
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Parameswaran, Kalaivani Nithyha. "Understanding the mechanisms of histone modifications in vivo." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ097/document.

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Les modifications post-traductionnelles (MPTs) d’histones sont apparues comme un acteur majeur de la régulation de l’expression des gènes. Cependant peu de choses sont connues sur le réel impact des MPTs sur la chromatine. Il a été suggéré que les MPTs d’histones (H2A, H2B, H3 et H4) ont le potentiel de moduler la fonction chromatinienne selon un « codehistone » en recrutant des protéines spécifiques de liaison. L’objectif de mon projet est d’approfondir la fonction de l’acétylation du domaine globulaire de l’histone H3 et de comparer cette modification avec celles des queues N-terminale in vi
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Bodey, Elijah D. "Evaluation of Cell Permeability of Intact Histone Complexes in Mammalian Cells." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1525705861000928.

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Kurtz, Katryn Lucille. "Structure of chromatin, protein transitions, and post-translational histone modifications in several sperm models." Doctoral thesis, Universitat de Barcelona, 2008. http://hdl.handle.net/10803/1158.

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The study of chromatin structure in several simple sperm models of increasing complexity was performed. Species demonstrating different types of sperm nuclear protein transitions and structural changes in spermatic chromatin during spermiogenesis were selected as models for comparison: "H" (non-histone proteins are removed), "H->P" (protamine displaces histones), and "H->Pp->P" (precursor protamine displaces histones, and subsequently is converted into the mature protamine). This study has an evolutionary focus, in which a primitive sperm model is identified, from which more complex models may
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Minshull, Tom. "Studying the effects of severe sepsis on histone post translational modifications using mass spectrometry." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/13244/.

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Sepsis is a very serious clinical syndrome. It results from the host's systemic response to an infectious agent. In order to treat sepsis an effective therapeutic target and robust biomarkers are required, so that the appropriate drug can be given at the right time. However, 30 clinical trials of therapies attempting to treat sepsis by blocking the action of TNF? or IL-1 have proven ineffective and a meta-analysis of 3370 studies examining 178 biomarkers found that none displayed the necessary specificity to be routinely and robustly used in clinical practice (Hotchkiss et al. 2013b; Pierrakos
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Bock, Ina [Verfasser]. "Recognition of post-translational histone modifications by antibodies and epigenetic reading domains / Ina Bock." Bremen : IRC-Library, Information Resource Center der Jacobs University Bremen, 2013. http://d-nb.info/1037013751/34.

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López, Ramos Rita. "Linker histone post-translational modifications and effects of phosphorylation on secondary structure and chromatin aggregation." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/131313.

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Les histones linker juguen un paper important en l’organització i manteniment de la cromatina en estructures d'ordre superior i en la regulació transcripcional. La histona H1 en vertebrats té una estructura característica en tres dominis: un domini N-terminal curt i flexible; un domini globular central; i un domini C-terminal llarg. Els dominis N- i C-terminals (CTD) són molt bàsics i es troben desestructurats en solució aquosa. La distribució de càrrega és bastant uniforme al llarg de tot el CTD. La interacció amb el DNA indueix un plegament total i estable del CTD en condicions fisiològiques
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Shahidian, Lara [Verfasser], and Robert [Akademischer Betreuer] Schneider. "The role of novel histone post-translational modifications in transcription / Lara Shahidian ; Betreuer: Robert Schneider." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1236502051/34.

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Karim, Muhammed. "Study of the post-translational modifications of histone H4 by Fourier transform ion cyclotron resonance mass spectrometry." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9780.

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Post-translational modification (PTM) of proteins is known to be a method by which protein function can be regulated. The addition of selected chemical groups at specific amino acid residues can act as a switch by which the function of a modified protein can be attenuated. Histones are a group of proteins which are found in the nucleus of eukaryotic cells and interact with DNA, providing it with a structural foundation upon which the chromosome is built. Histone proteins have numerous sequence variants and are known to be extensively post-translationally modified in a dynamic manner. These mod
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Goudarzi, Afsaneh. "Male genome programming guided by histone acylations." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV059/document.

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Le principal intérêt de nos études présentées dans ce manuscrit, correspond à la compréhension des évènements, reliés aux acylations d’histones au niveau des lysines (Ks) dans les cellules germinales post méiotiques, qui régulent spécifiquement l’expression des gènes à l’échelle du génome entier.Dans la première partie de mon travail, nous avons élaboré une stratégie afin d’analyser le rôle des « histones acetyl transférases » (HATs), Cbp et p300, dans les cellules germinales post méiotiques. Pour ce faire, nous avons généré une lignée de souris conditionnellement et partiellement invalidée po
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Books on the topic "Histone post-translational modifications (hPTMs)"

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Chess, Andrew, and Schahram Akbarian. The Human Brain and its Epigenomes. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0003.

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Conventional psychopharmacology elicits an insufficient therapeutic response in more than one half of patients diagnosed with schizophrenia, bipolar disorder, depression, anxiety, or related disorders. This underscores the need to further explore the neurobiology and molecular pathology of mental disorders in order to develop novel treatment strategies of higher efficacy. One promising avenue of research is epigenetics.Deeper understanding of genome organization and function in normal and diseased human brain will require comprehensive charting of neuronal and glial epigenomes. This includes D
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Book chapters on the topic "Histone post-translational modifications (hPTMs)"

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Senda, Toshiya, and Naruhiko Adachi. "Post-Translational Modifications, Histone." In Encyclopedia of Systems Biology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_1490.

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Ratnakumar, Kajan, Avnish Kapoor, and Emily Bernstein. "Regulation of Chromatin Structure and Transcription Via Histone Modifications." In Post-Translational Modifications in Health and Disease. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6382-6_15.

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Vidali, Giorgio, Nicoletta Ferrari, and Ulrich Pfeffer. "Histone Acetylation: A Step in Gene Activation." In Advances in Post-Translational Modifications of Proteins and Aging. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-9042-8_49.

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Zhou, Mowei, Si Wu, David L. Stenoien, et al. "Profiling Changes in Histone Post-translational Modifications by Top-Down Mass Spectrometry." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6518-2_12.

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Tanguay, Robert M., and Richard Desrosiers. "Histone Methylation and Modulation of Gene Expression in Response to Heat Shock and Chemical Stress in Drosophila." In Advances in Post-Translational Modifications of Proteins and Aging. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-9042-8_28.

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Castillo, Josefa, Gerardo López-Rodas, and Luis Franco. "Histone Post-Translational Modifications and Nucleosome Organisation in Transcriptional Regulation: Some Open Questions." In Advances in Experimental Medicine and Biology. Springer Singapore, 2017. http://dx.doi.org/10.1007/5584_2017_58.

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Zhang, Yu, Wei Shen, Jin Zou, and Shibo Ying. "p300/CBP Methylation is Involved in the Potential Carcinogenic Mechanism of Lung Cancer." In Post-Translational Modifications in Cellular Functions and Diseases. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97241.

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p300/CBP is involved in the expression of a wide range of genes, both as a histone acetyltransferase (HAT) and as a coactivator of transcription factors. p300/CBP is the specific substrate of CARM1, and its KIX domain and GBD domain are the main sites methylated by arginine methyltransferase 4 (PRMT4/CARM1). p300/CBP plays an important role in lung cancer, which is a cell cycle disease. More importantly, the methylation of p300/CBP by CARM1 affects the progression of lung cancer through the cAMP-PKA pathway, p53 pathway and ER pathway. The structure, function, methylation modification sites, m
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Wolffe, Alan P. "Histone modification and transcriptional competence." In Nuclear Organization, Chromatin Structure, and Gene Expression. Oxford University PressOxford, 1997. http://dx.doi.org/10.1093/oso/9780198549239.003.0003.

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Abstract Chromosomes are highly differentiated and dynamic structures. Transcriptional activity and chromosome morphology vary throughout the cell cycle. These events can be correlated with global changes in the post-translational modification of the histone proteins that occur in all chromosomes. At a more local level individual chromosomes, chromatin domains, or genes can have their transcription modulated through developmental or signal transduction pathways. These local transitions in gene activity can also be related to changes in chromatin structure and histone modification. The focus of
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Mitchell, Amanda C., Yan Jiang, Cyril J. Peter, Ki A. Goosens, and Schahram Akbarian. "The Brain and Its Epigenome." In Neurobiology of Mental Illness, edited by Karl Deisseroth. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199934959.003.0013.

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Exploration of the epigenome—collectively defined by DNA methylation, post-translational histone modifications, histone variants and other regulators of genome organization and function—has emerged as one of the most prolific areas of the basic and clinical neurosciences alike. This is due to a number of recent developments, including a wealth of genetic information on psychiatric disorders indicating that many risk-associated DNA variants and mutations do not affect protein coding sequences. Furthermore, the hopeful prospect of chromatin modifying drugs to lead to novel therapeutic options—wh
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Umamaheswari, A., A. Puratchikody, and Sakthivel Balasubramaniyan. "Target Identification of HDAC8 Isoform for the Treatment of Cancer." In Advances in Medical Technologies and Clinical Practice. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-7326-5.ch007.

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Target identification has been considered as a chief parameter in drug discovery as it fully characterizes on-target and off-target effects of drug binding. Cell signaling receptors, structural proteins, and post-translational modifications of histones by histone deacetylases are the most widespread targets that are progressively being explored. The FDA approved histone deacetylases inhibitors and the majority of HDACi in and out of clinical trials based on the activities of 11 isoforms of the enzyme in non-selective influence approach. Unfortunately, reported HDACi does not possess a high deg
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Conference papers on the topic "Histone post-translational modifications (hPTMs)"

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Brenner, Benjamin, Daniela Matei, Cheng Sun, and Hao F. Zhang. "Quantifying the spatial distribution of post-translational histone modifications using 3D spectroscopic single-molecule localization microscopy." In Single Molecule Spectroscopy and Superresolution Imaging XVIII, edited by Rainer Erdmann, Felix Koberling, and Mike Heilemann. SPIE, 2025. https://doi.org/10.1117/12.3041466.

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Beaudet, Lucille, Jean-Philippe Lévesque Sergerie, Marie Boulé, et al. "Abstract 3879: High-throughput, homogeneousin cytoassays to monitor histone H3 post-translational modifications." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3879.

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Xu, Songhui, Lingling Fan, Xiaolu Cui, et al. "Abstract 4389: Post-translational modifications of histone demethylase JMJD1A in prostate cancer cells." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-4389.

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Xu, Songhui, Lingling Fan, Xiaolu Cui, et al. "Abstract 4389: Post-translational modifications of histone demethylase JMJD1A in prostate cancer cells." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-4389.

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Carrero, Gustavo, Nikhil Raghuram, John Th’ng, et al. "A Method for Assessing Kinetic Changes of Histone H1 after Post-Translational Modifications." In NUMERICAL ANALYSIS AND APPLIED MATHEMATICS: International Conference on Numerical Analysis and Applied Mathematics 2009: Volume 1 and Volume 2. AIP, 2009. http://dx.doi.org/10.1063/1.3241319.

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Davies, GF, AR Ross, BH Juurlink та HA Troy. "The thiazolidinedione peroxisome proliferator-activated receptor gamma (PPARγ) agonist troglitazone alters histone post-translational modifications in MCF7 breast cancer cells." У CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-2140.

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