Journal articles: 'Histostructure'

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O. A., Zayseva, Makhsumov Sh. M., Djanaev G. Yu., and Mamadaliev Sh. M. "Effect of HYD Drugs on Hemolytic Anemia Induced by Phenylhydrazine Hydrochloride." European Journal of Medical Genetics and Clinical Biology 1, no. 1 (2023): 149–54. http://dx.doi.org/10.61796/jmgcb.v1i1.268.

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In conclusion, the conducted experiments showed that the histostructure of the vital internal organs of rats in the control and experimental groups was almost the same. At the same time, drug-related histomorphological changes in their histostructure were not noted. It should be noted separately that the study of the histostructure of the liver and kidney from the parenchymatous organs of the animals that received the studied tincture showed that some morphological signs indicating their functional activity appeared. Therefore, long-term administration of the antianemic compound - DOY tincture to the body does not cause chronic poisoning in animals and any negative reactions in the histostructure of vital internal organs and biochemical analyzes of peripheral blood.

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Zayseva, O.A. Makhsumov Sh.M. Djanaev G.Yu. Mamadaliev Sh.M. "EFFECT OF HYD DRUGS ON HEMOLYTIC ANEMIA INDUCED BY PHENYLHYDRAZINE HYDROCHLORIDE." INTERNATIONAL BULLETIN OF MEDICAL SCIENCES AND CLINICAL RESEARCH 3, no. 9 (2023): 46–52. https://doi.org/10.5281/zenodo.8368906.

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In conclusion, the conducted experiments showed that the histostructure of the vital internal organs of rats in the control and experimental groups was almost the same. At the same time, drug-related histomorphological changes in their histostructure were not noted. It should be noted separately that the study of the histostructure of the liver and kidney from the parenchymatous organs of the animals that received the studied tincture showed that some morphological signs indicating their functional activity appeared. Therefore, long-term administration of the antianemic compound - DOY tincture to the body does not cause chronic poisoning in animals and any negative reactions in the histostructure of vital internal organs and biochemical analyzes of peripheral blood.

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Vinogradov, Aleksandr Anatol'evich, and Evgeniya Sergeevna Simakova. "AGE-RELATED CHANGES IN RAT LIVER HYDRATION AND HISTOSTRUCTURE." Ulyanovsk Medico-biological Journal, no. 3 (September 26, 2022): 120–28. http://dx.doi.org/10.34014/2227-1848-2022-3-120-128.

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One of the aging hypotheses is based on the fact that the percentage of water in the human body decreases with age. To a greater extent, the loss of water affects the most energy-dependent organs, such as liver, which undergoes a number of structural compensatory-adaptive changes. The parameters of age-related changes are currently understudied. However, they should be taken into account when determining the actual organ transformations in experiments. The purpose of the study was to examine the change in the level of total water and liver histostructure in rats during a 75-day observation. Materials and Methods. The changes in the level of total water in the liver parenchyma were assessed in young outbred intact rats during 75-day observation. The authors examined liver histostructure on sections stained with hematoxylin-eosin and picrofuchsin (Van Gieson's stain). Results. A decrease in the level of total water in the rat liver parenchyma by 0.54±0.042 % was observed during a 75-day observation. At the same time, no visible changes were detected in the liver histostructure. Conclusion. During the trial a decrease in the level of total water in the liver of intact animals was observed. It did not affect the change in liver histostructure.

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Meyramov, Gabit Gabdullowich, Klaus-Dieter Kohnert, Altynay Zhuparovna Shaibek та ін. "Indirect method of histochemical assessment of insulin content in pancreatic β-cells". Bulletin of the Karaganda University. “Biology, medicine, geography Series” 109, № 1 (2023): 160–66. http://dx.doi.org/10.31489/2023bmg1/160-166.

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Methods for analysis the state of histostructure and insulin and zinc content in pancreatic tissue allow to estimate either a state of histostructure alone or visual insulin content in ß-cells. Zinc content indicating the content of deposited insulin and the ability of ß-cells to form this form of hormone is possible using an additional method that increases the volume of work and complicates investigation. Authors have proposed a method that allows to simultaneously evaluate both the state of the histostructure and the quantitative content of deposited insulin and zinc in ß-cells of the pancreas. It has been experimentally confirmed that both the aldehyde-fucshsin method of insulin staining and Dithizone method for staining of zinc-ions in ß-cells can be separately used simultaneously for quantitative analysis of the content of deposited insulin and zinc in ß-cells. It has been experimentally confirmed that both the aldehyde-fucshsin method of insulin staining and the Dithizone method of detecting zinc in ß-cells can be separately used simultaneously for quantitative analysis of the content of deposited insulin and zinc in ß-cells. The use of both methods allows not only to assess the state of the histostructure, but to assess the content and functional ability of ß-cells to synthesize insulin, as well as to form its deposited form using zinc.

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Volkova, L. A., A. N. Vetokh, N. A. Volkova, Z. Alabdallah, and А. А. Nikishov. "FEATURES HISTOSTRUCTURE ORGANS OF TRANSGENIC CHICKEN." Theoretical & applied problems of agro-industry 38, no. 5 (2018): 34–37. http://dx.doi.org/10.32935/2221-7312-2018-38-5-34-37.

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Tamm, Tamara I., Valentyn V. Nepomniashchyi, Sergey B. Pavlov, Ivan M. Mamontov, Olena A. Shakalova, and Olga B. Litvinova. "Histostructure of bone tissue after restoration of blood flow in patients with ischemic form of diabetic foot syndrome." Polski Merkuriusz Lekarski 52, no. 6 (2024): 630–37. https://doi.org/10.36740/merkur202406103.

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Aim: To study the histostructure of bone tissue in case of disruption of its blood supply and after restored blood flow in patients with ischemic form of diabetic foot syndrome. Materials and Methods: The histostructure of bone fragments in 25 patients with isolated ischemic form of diabetic foot syndrome was studied. Bone tissue biopsy specimens from 6 patients against the background of progressive ischemia were studied. In addition, the histostructure of bone tissue after revascularization with complete restoration of blood flow in 19 patients was studied. Results: The analysis of bone tissue biopsy specimens showed that disruption of blood supply of the limb tissues for a long time leads to impaired matrix calcification, decreased cortex thickness, widening of osteon channels and sparse trabecular network in the bone structure. Such changes were the signs of bone resorption that was not clinically or radiologically apparent. Revascularization with full restoration of blood flow promoted the appearance of signs of bone tissue regeneration in the form of vessel formation in bone and periosteum. Conclusions: Adequate blood flow is an important clinical factor contributing to the restoration of bone regeneration in patients with ischemic form of diabetic foot syndrome.

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Filimonova, G. N., N. I. Antonov, and A. A. Emanov. "Osteogenesis and Histostructure of Femoral Muscles When Modeling a Femoral Fracture with Immediate or Delayed Osteosynthesis Using an Interlocking Intramedullary Antegrade Rod." Journal Biomed, no. 2 (June 10, 2020): 78–88. http://dx.doi.org/10.33647/2074-5982-16-2-78-88.

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Interlocked intramedullary osteosynthesis is the most common method for treating femoral shaft fractures. The aim — to reveal specifi c characteristics of the histostructure of canine femoral muscles when healing femoral fractures under osteosynthesis using interlocking intramedullary reinforcement with an antegrade metal rod. Femoral shaft fractures were modelled in 9 mongrel dogs. The fractures were fi xed with an intramedullary rod. In Group I (n=4), osteosynthesis was started immediately after bone injury. In Group II (n=5), osteosynthesis was started 4 days after fracture (delayed osteosynthesis). M. biceps femoris and M. quadriceps femoris were studied. In Group I and Group II, bone healing occurred following 42 and 70 days, respectively. A unifi ed bone marrow cavity and cortical layer had been formed by day 70 and day 100 in Group I and Group II, respectively. The histostructure of M. quadriceps femoris in Group I remained largely unchanged throughout the experiment, while M. biceps femoris underwent the process of structural reorganization on days 42 and 70 of the experiment. The Group of delayed osteosynthesis demonstrated changes in the histostructure of both muscles, including an increased diversity of fi bre diameters, an increased number of nuclei in myocytes, fi brosis of the interstitial space and perimysial arterial vessels. These changes were more pronounced in M. biceps femoris. Three months after injury, the histostructure of the muscles under study, even in the Group of delayed osteosynthesis, had no signifi cant differences and tended to the intact norm. In femoral fractures, the earliest possible fi xation of bone fragments with an inter locking antegrade intramedullary rod is recommended. A complete bone healing in such cases occurs a month earlier than in those with delayed osteosynthesis. The femoral muscles of the anterior group are injured to a lesser extent than those of the posterior group.

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Pavlovich, S. I., N. G. Grushka, O. A. Kondratska, et al. "Histostructural Changes in Immunocompetent Organs, Liver, and Lungs During Experimental Endotoxemia Induced by Lipopolysaccharide." Fiziolohichnyĭ zhurnal 70, no. 5 (2024): 66–71. http://dx.doi.org/10.15407/fz70.05.066.

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The purpose of the work was to study morphological changes in immunocompetent organs, liver and lungs during experimental endotoxemia induced by lipopolysaccharide (LPS). The histological method with hematoxylin-eosin staining and subsequent microscopic analysis was used in the work. The histostructural damage to the immune system organs (thymus, spleen, lymph nodes) occurs in experimental endotoxemia caused by LPS. There is a circulatory disorder with morphological changes in all layers of the vascular walls. Necrobiotic and necrotic damage to organ cells was also revealed. The liver of experimental animals underwent especially pronounced changes in histostructure. Significant microcirculation disorders with dilation and congestion of vessels of various sizes and significant damage to endothelial cells were identified. Necrotic changes in hepatocytes were accompanied by a significant increase in stellate reticuloendotheliocytes and increased lymphocytic infiltration, which is the basis for liver dysfunction and the development of an inflammatory immune reaction. In conclusion, the data obtained on the morphological manifestations of endotoxemic damage can serve as the basis for the development of effective therapeutic approaches in the treatment of LPS-induced internal organ damage.

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Satybaldiev, M. A., A. M. Ergesheva, and A. E. Seytkulova. "HISTOSTRUCTURE OF INTRAMURAL LYMPHOID FORMATIONS OF THE HEART." Eurasian Medical Journal, no. 4 (2021): 29–33. http://dx.doi.org/10.52680/16948254_2021_4_29.

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Gubergrits, N. B., О. A. Krylovа, and М. C. Opikhailo. "Features of the pancreatic histostructure in chronic pancreatitis." Experimental and Clinical Gastroenterology 163, no. 3 (2019): 38–42. http://dx.doi.org/10.31146/1682-8658-ecg-163-3-38-42.

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Marenkov, Oleh, Kirill Holoborodko, Yuliia Voronkova, and Vadim Gorban. "Effect Of Zinc And Cadmium Ions On Histostructure Of Antennal Glands Of Marbled Crayfish Procambarus Fallax (Hagen, 1870) F. Virginalis (Decapoda)." Acta Biologica Universitatis Daugavpiliensis 17, no. 2 (2017): 211–16. https://doi.org/10.5281/zenodo.12648495.

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Marenkov, Oleh, Holoborodko, Kirill, Voronkova, Yuliia, Gorban, Vadim (2017): Effect Of Zinc And Cadmium Ions On Histostructure Of Antennal Glands Of Marbled Crayfish Procambarus Fallax (Hagen, 1870) F. Virginalis (Decapoda). Acta Biologica Universitatis Daugavpiliensis 17 (2): 211-216, DOI: 10.5281/zenodo.12648495

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12

Kosilov, Vladimir I., Nail M. Gubaydullin, Igor R. Gazeev, Irina V. Mironova, Zulfiya A. Galieva, and Ilmira A. Rakhimzhanova. "EFFECT OF THE HEIFER GENOTYPE ON THE SKIN HISTOSTRUCTURE." Vestnik Bashkir State Agrarian University, no. 4 (2022): 70–74. http://dx.doi.org/10.31563/1684-7628-2022-64-4-70-74.

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13

Dmitrik, I. I., G. V. Zavgorodnyaya, and M. I. Pavlova. "Age-related changes in the skin structure and wool quality in sheep of Artlukh merino breed." Glavnyj zootehnik (Head of Animal Breeding), no. 5 (May 1, 2021): 47–54. http://dx.doi.org/10.33920/sel-03-2105-06.

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Increasing the production of wool and improving its quality characteristics for a number of years remains an urgent issue in breeding work with fine-fleeced sheep. In this regard the main purpose of the research was a comparative assessment of the age dynamics of the main properties of wool and the histostructure of the skin of the young ewes of Artlukh merino breed in the farm AC “Krasny Oktyabr” in the Kazbekov district in the Republic of Dagestan. It has been found that at the age of one year in the experemental young ewes the epidermis increased by 21,2 %, the pilar and reticular layers by 2,9 and 12,8 %, respectively, and the total skin thickness by 6,1 %. The biggest increase in skin thickness was due to the epidermis and the reticular layer as the number of fat cells increased. The width of the secretory parts of the sweat glands increased by 7,1 %, the sebaceous glands by 9,6 %, in this regard the amount of wool fat increased by 7,6 %. The studied parameters of the skin histostructure revealed that the number of hair follicles decreased by 6,8 % with age. This is due to the increase in the area of the skin due to the growth of the animal. The change in the basic properties of wool was as follows: the diameter of wool fibers increased by 5,6 %, the strength of wool decreased by 13,8 %. Comprehensive studies allowed us to recommend testing the main properties of wool and indicators of the histostructure of the skin of experimental animals when improving existing breeds and breeding new breeds and lines of sheep. Histological studies of the skin should be carried out at the age of 4,5 months, and the most objective indicators are the ratio of secondary and primary follicles, this will allow for early selection of lambs by wool density.

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Nozdrin, Vsevolod, Ruslan Khairov, Vasily Grigoriev, Erlan Berdaliev, and Sheikh-Magomed Denelkhanov. "RESULTS OF SURGICAL TREATMENT OF TUMORS SPINAL CORD AND SPINE WITH COMPRESSION OF NEURAL STRUCTURES." CASPIANJOURNALOF MEDICINE AND PHARMACY 5, no. 4 (2024): 14–19. https://doi.org/10.17021/2712-8164-2024-14-19.

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Spinal cord tumors, differing in their histostructure, the nature of growth and the ratio to the diameter of the spinal cord, continue to be a difficult problem, both in terms of choosing the optimal treatment tactics and results. We present the results of surgical treatment of the most common spinal chord neoplasms in 2022, conducted in the Alexandro-Mariinskaya Regional Clinical Hospita. The purpose of the study – to present the results of surgical treat-ment of spinal cord and spine tumors with secondary compression of neural structures that differ in histostructure, de-gree of malignancy and level of lesion. In 2022, 19 patients were operated on by various methods in the Alexandro-Mariinskaya Regional Clinical Hospita. 3 clinical cases with different histostructure and topographic-anatomical level of lesion are presented. Surgical treatment of spinal cord tumors was performed in 19 patients with different histostruc-ture and topographic and anatomical lesion levels. Using the example of three clinical cases, the choice of various sur-gical treatment tactics that are most optimal for maintaining the patient's quality of life is demonstrated. The analysis of the surgical manual, its relationship with the prognostic trend, which affect the overall survival of patients with tu-mors of the spinal cord and spine. The dependence of a number of factors was revealed: the histological structure, the degree of “aggressiveness” of the oncological process, the possible spread of metastatic foci in the body. This, in turn, is interconnected with modern methods of diagnosis, surgical and adjuvant treatment, neurological and somatic compen-sation of the patient, which will allow to determine and transfer the aggressiveness of the indicated treatment method. The available modern equipment, accumulated surgical experience and the chosen active tactics for the maximum total removal of the lesion justified themselves, allowing to achieve a good functional result in 18 of the 19 operated patients.

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Samatov, N. Kh, and M. M. Ibatullin. "Clinical evaluation of perifocal edema in patients with supratentorial brain tumors." Kazan medical journal 67, no. 3 (1986): 192–93. http://dx.doi.org/10.17816/kazmj66781.

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We examined 37 patients (18 men and 19 women) with supratentorial brain tumors. Nineteen patients had intracerebral tumors and 18 patients had extracerebral tumors. The patients were subdivided into different groups depending on the predominant localization of the neoplasm, histostructure and malignancy of the tumors, phases of the clinical course of the disease.

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Rubnikovich, S. P., I. S. Khomich, and Yu L. Denisova. "Morphological changes in the bone tissue around dental implants after low-frequency low-intensity ultrasound applications." Proceedings of the National Academy of Sciences of Belarus, Medical series 17, no. 1 (2020): 20–27. http://dx.doi.org/10.29235/1814-6023-2020-17-1-20-27.

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The article presents the results of a histological study of morphological changes in bone tissue around established dental implants after exposure to low-intensity, low-frequency ultrasound during dental implantation. Histological studies of tibia bone blocks were conducted in three groups of laboratory animals around installed dental implants, which were subjected to different modes of ultrasonic exposure. In the course of studies, it was found that the processes of osseointegration of dental implants in animals of all groups occurred without staging. In the early stages, granulation tissue was formed, which was subsequently replaced by reticulofibrotic bone tissue, and then by more mature lamellar tissue. The timing and degree of bone maturation, as well as the indicators of osseointegration in groups using low-intensity pulsed ultrasound and without it, were significantly different. It was shown that the ultrasound effect on peri-implant tissues induces osteoreparative processes, stimulating neoangiogenesis in granulation and newly formed bone tissue. It has been established that ultrasonic exposure of implants, and then peri-implant tissues during dental implantation, promotes the formation of bone tissue, the histostructure of which is similar to the histostructure of the maternal bone at earlier stages.

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Stepanchuk, A. P., I. L. Fedorchenko, Ya A. Tarasenko, O. O. Tykhonova, and B. M. Filenko. "Histostructure of the Normal Human Greater Omentum and in Peritonitis." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 5 (2021): 127–33. http://dx.doi.org/10.26693/jmbs06.05.127.

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The purpose of the work was to study the histological structure of the greater omentum in the people of second mature and elderly age in normal condition and in peritonitis. Materials and methods. The materials of the study were 40 greater omenta of deceased people (20 males and 20 females) of the second mature and elderly age without pathology in the abdominal cavity and 10 greater omenta of deceased people from peritonitis taken in accordance with the cooperation agreement. Pieces of greater omenta were fixed with a 10% solution of neutral formalin. Paraffin blocks were made according to the traditional method, followed by making sections that were stained with hematoxylin and eosin. Histological specimens were studied using a light microscope "MICROmed" XS-3320 in transmitted light using an increase of ×40, ×100, ×400 with the photographing of micropreparations on the camera Ningero Sheng Heng Optics and Electronics Co. Results and discussion. The findings of the study showed that the histological structure of the tissue of the greater omentum in women and men of these ages has common structural features. Histological sections stained with hematoxylin and eosin revealed that normally the outside of the greater omentum is covered with a solid layer of mesotheliocytes, located on the basal plate, deeper there were “milk spots”, white adipocytes, which formed individual fat particles, separated by connective tissue fibers. “Milk spots” do not have capsules, in contrast to lymph nodes, and contain lymphocytes and macrophages that emerge from their fenestrated postcapillary venules and migrate into the abdominal cavity through “stigmas”. Normally, active and inactive “milk spots” are present in the greater omentum in adults. “Milk spots” had an oval, irregular and spherical shape and different sizes. In the thickness of the tissue of the greater omentum there were lymph nodes, which, in contrast to the "milk spots" on the outside were covered with a connective tissue capsule. In the thickness of the nodule, trabeculae extend from the capsule. Marginal and medullary sinuses were determined. Lymphocytes were the main cellular component of lymph nodes. Conclusion. In peritonitis, disruption of the continuous mesothelial cover of the greater omentum, resulted from disintegration of mesothelial cells; some areas of their adhesion and desquamation were observed. Areas with inflammatory infiltration, plethora of arterial and venous microvessels and an increase in active “milk spots” with a high content of lymphocytes were found in the fat particles of the greater omentum

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Толочка, Василий Васильевич, Григорий Владимирович Пакулев, Баир Дылгырович Гармаев, Дылгыр Цыдыпович Гармаев, and Владимир Иванович Косилов. "HISTOSTRUCTURE OF THE SKIN OF BEEF BULLS IN PRIMORSKY KRAI." Вестник Бурятской государственной сельскохозяйственной академии имени В. Р. Филиппова, no. 4(69) (December 28, 2022): 77–84. http://dx.doi.org/10.34655/bgsha.2022.69.4.010.

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В статье приводятся результаты влияния генотипа бычков специализированных мясных пород и сезона года на микроструктуру их кожи в Приморском крае. Целью исследования являлось определение влияния генотипа молодняка на общую толщину кожи и отдельных ее слоев, диаметр коллагеновых волокон, развитие ее железистого аппарата. Установлено, что в летний период по сравнению с зимним сезоном года у бычков подопытных групп толщина эпидермиса повысилась на 9,3-9,9 мкм (25,52-27,42%), пилярного слоя - на 305,8-379,5 мкм (30,69-42,03%), ретикулярного - на 281,8-327,4 мкм (12,71-14,57%), общая толщина кожи - на 629,7-696,5 мкм (19,55-22,84%). Повысилась также глубина залегания волос, сальных и потовых желез при уменьшении их количества на 1 мм площади кожи. Характерно, что лучшим развитием кожного покрова отличались бычки калмыцкой породы, минимальная толщина всех слоев кожи была характерна для бычков абердин-ангусской породы, молодняк герефордской породы занимал промежуточное положение. Аналогичная закономерность отмечалась по толщине коллагеновых волокон, глубине залегания волос, сальных и потовых желез и их количеству на 1 мм кожи. Результаты гистологического исследования кожи свидетельствуют об увеличении толщины ретикулярного слоя дермы у бычков всех генотипов в летний период по сравнению с зимним. Это обусловлено ростом и развитием животных. Дерма кожи бычков всех генотипов отличалась ромбовидным переплетением коллагеновых пучков, что свидетельствует о достаточно высоких прочностных свойствах кожевенного сырья. The article presents the results of the influence of the genotype of bulls of specialized meat breeds and the season of a year on the microstructure of the skin in the Primorsky Krai. The aim of the study was to determine the effect of the genotype of young animals on the overall thickness of the skin and its individual layers, the diameter of collagen fibers, the development of its glandular apparatus. It was found out that in the summer period, compared with the winter season, the thickness of the epidermis increased by 9.3-9.9 microns (25.52-27.42%), the papillary layer - by 305.8-379.5 microns (30.69-42.03%), the reticular layer - by 281.8-327.4 microns (12.71-14.57%), the total thickness of the skin increased by 629.7-696.5 microns (19.55-22.84%). The depth of hair, sebaceous and sweat glands has also increased with a decrease in their number by 1 mm of the skin area. It is significant that the best development of the skin the bulls of the Kalmyk breed were distinguished, the minimum thickness of all skin layers was characteristic of Aberdeen-Angus bulls, the young Hereford breed occupied an intermediate position. A similar pattern was observed concerning the thickness of collagen fibers, the depth of hair, sebaceous and sweat glands and their number per 1 mm of skin. Results of histological studies of the skin show increase in thickness of the reticular layer at bulls of all genotypes during the summer period in its comparison with the winter one. The reason is in the growth and development of animals. Dermis of the skin of bulls belonging to different genotypes was presented by rhomb-shaped plexus of collagen bundles that indicates a good quality of hides.

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Sergienko, L. Yu, O. V. Perets, O. V. Kartavtseva, G. M. Cherevko, L. M. Tolmachova, and T. V. Bondarenko. "HISTOFUNCTIONAL FEATURES OF VISCERAL ADHESIVE TISSUE THE DESCENDANTS OF GESTALLY STRESSED MOTHERS." Problems of Endocrine Pathology 33, no. 3 (2010): 83–89. http://dx.doi.org/10.21856/j-pep.2010.3.13.

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A comparative study of the histostructure of adipose tissue in females was performed rats - offspring of intact and gestational stressed mothers in the basal state and after the action of stress factors. It was found that the stress of mature offspring leads to the formation of a hypertrophic type of obesity in intact animals and provokes adipocyte hyperplasia and adipose tissue inflammation in rats stressed during the antenatal period.

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Andreeva, I. V., A. A. Vinogradov, R. Yu Simakov, A. A. Natalskiy, and M. A. Turkova. "The effect of chronic predatory stress on the histostructure of the rat liver." Siberian Journal of Clinical and Experimental Medicine 39, no. 3 (2024): 136–43. http://dx.doi.org/10.29001/2073-8552-2024-39-3-136-143.

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One of the topical issues of modern circulatory physiology is the study of the peculiarities of the influence of chronic emotional stress on the histostructure of the liver.Aim: To study changes in the histostructure of the liver in the simulation of chronic predatory stress.Methodology and Research Methods. The study was conducted on 60 male Wistar rats weighing 220–370 g, divided into control and experimental groups of 30 rats each. Modeling of chronic predatory stress was performed according to the method of V.E. Zeilikman et al. (2021). Histological examination of the liver was performed in animals of the control and experimental groups. The preparations were stained with hematoxylin-eosin.Results. Under conditions of chronic predatory stress, stress-induced changes develop in the liver of rats. Transformation of hepatocytes occurs with the development of dystrophic changes, expansion and fullness of sinusoidal capillaries with compression of hepatic beams and destruction of hepatic lobules, a decrease in the parenchymal-stromal ratio. Foci of foamy accumulation of macrophages appear without signs of necrosis, single or group apoptotic hepatocytes. Necrotic foci are formed. The number of Kupffer cells and binucleated hepatocytes increases.Conclusion. With chronic predatory stress, the processes of dystrophy, necrosis and apoptosis of hepatocytes, signs of phagocytosis and regenerative processes, and decreased immune protection develop in the liver of rats.

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Pogodaev, V. A., A. N. Arilov, S. N. Mangutov, and E. V. Khechev. "Product properties and histostructure of young sheepskin of the Dorper Breed." IOP Conference Series: Earth and Environmental Science 624 (January 8, 2021): 012132. http://dx.doi.org/10.1088/1755-1315/624/1/012132.

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Shakhbanov, R. K., M. N. Asadulaeva, U. B. Aliyeva, and S. N. Alieva. "MORPHOLOGICAL FEATURES OF THE HISTOSTRUCTURE OF THE PANCREAS IN CHRONIC PANCREATITIS." Journal of Volgograd State Medical University 80, no. 4 (2021): 139–43. http://dx.doi.org/10.19163/1994-9480-2021-4(80)-139-143.

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The morphological features of the pancreas in clinical and morphological forms of chronic pancreatitis have been investigated. Materials and methods. We studied histological preparations of the pancreas of 60 patients with various forms of chronic pancreatitis. Results. Revealed scant inflammatory infiltration of the pancreatic parenchyma (represented by lymphocytes, plasma cells), atrophic and fibrotic changes, which were characterized by unidirectionality. Also revealed fibrotic changes in the pancreas of two types, loose and dense fibrosis, which reflects the qualitative state of the connective tissue in different forms of chronic pancreatitis. Loose fibrosis is characteristic of mild to moderate severity of fibrous pancreatitis, and dense fibrosis of a high degree and complete fibrosis. Conclusions. The morphological picture of fibrotic changes in the pancreas does not depend on the form of the disease and is characterized by mild fibrosis in 6,6 % of patients, moderate in 20,0 %, expressed in 16,7 %, complete fibrosis in 56,7 %

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Shimizu, Yuzuru. "A study of histostructure of fused human enamel by laser irradiation." Nihon Hotetsu Shika Gakkai Zasshi 33, no. 5 (1989): 1212–25. http://dx.doi.org/10.2186/jjps.33.1212.

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Pogodaev, V. A., A. N. Arilov, S. N. Mangutov, and E. V. Khechev. "Product properties and histostructure of young sheepskin of the Dorper Breed." IOP Conference Series: Earth and Environmental Science 624 (January 8, 2021): 012132. http://dx.doi.org/10.1088/1755-1315/624/1/012132.

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Petrov, P., A. Bochukov, G. Penchev, and V. Gerzilov. "Histostructure of different quality classes of fattened liver from mule ducks." Bulgarian Journal of Veterinary Medicine 20, no. 4 (2017): 319–26. http://dx.doi.org/10.15547/bjvm.1034.

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Kramarenko, Aleksandr, Sergei Kramarenko, Anna Lykhach, and Vadim Lykhach. "FRACTAL ANALYSIS OF THE PIGS MUSCLE TISSUE HISTOSTRUCTURE: A PRELIMINARY STUDY." Scientific and Technical Bulletin of the Institute of Animal Science NAAS of Ukraine, no. 121 (2019): 146–56. http://dx.doi.org/10.32900/2312-8402-2019-121-146-156.

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Yerofeyeva, A. M. V., O. A. Antipova, I. A. Siamionik, et al. "ANTINOCICEPTIVE AND REPARATIVE ACTION OF ADIPOSE-DERIVED MESENCHYMAL STEM CELLS IN EXPERIMENTAL LIMB ISCHEMIA." Journal of the Grodno State Medical University 22, no. 1 (2024): 19–26. http://dx.doi.org/10.25298/2221-8785-2024-22-1-19-26.

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Background. Transplantation of adipose-derived mesenchymal stem cells (ADMSCs) appears to be a promising method for relieving pain in peripheral arterial diseases and revascularization of an ischemic limb. Objective. To study the effect of various modes of local administration of ADMSCs on nociceptive reactions, gait parameters, and soft tissue histostructure of the ischemic limb in rats. Material and methods. Experimental limb ischemia was induced in Wistar rats by transection of the common femoral artery with preliminary bilateral ligation. On the 7th day of the experiment, allogeneic ADMSCs were transplanted to the corresponding groups of animals in the amount of 1×106 cells/kg (single and double administration). An assessment of nociceptive reactions to a mechanical stimulus, gait parameters, as well as the histostructure of the soft tissues in the rat hind limb with ischemia was carried out. Results. Transplantation of ADMSCs at a dose of 1×106 cells/kg into the area of the hind limb ischemia, regardless of the multiplicity, weakened mechanical hyperalgesia, produced a protective effect on the myelin sheaths of nerve fibers, and contributed to the restoration of gait parameters. A single transplantation of ADMSCs proved to be more effective in terms of anti-inflammatory and anti-ischemic effects on the tissues of the ipsilateral limb. Conclusions. Local allogeneic transplantation of ADMSCs effectively attenuated mechanical hyperalgesia and gait disturbances caused by arterial transection, and prevented thinning of the myelin sheath of nerves in the area of vessel damage.

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Tamm, Т. I., V. V. Nepomnyaschy, O. А. Shakalova, and А. Ya Barduck. "Intestine wall histostructure peculiarities with peritonitis and mechanical intestine obstruction (experimental study)." Biomedical and Biosocial Anthropology, no. 36 (July 10, 2020): 27–34. http://dx.doi.org/10.31393/bba36-2019-05.

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Today, the histological criteria for differential diagnosis of dynamic ileus due to peritonitis and mechanical obstruction of the intestine remain undeveloped. In this regard, the aim of the work was to establish the difference in morphological changes occurring in the intestinal wall during dynamic and mechanical ileus in the experiment. The experiment was conducted on 33 sexually mature Wistar rats. In 15 animals of the first group, mechanical ileus was modeled by ligation of the lumen of the small intestine at the middle of the distance between the duodenojejunal junction and the ileocecal angle. In 15 rats of the second group, a dynamic ileus model was formed in the form of peritonitis by introducing fecal suspension into the lumen of the abdominal cavity. The control group included 3 animals who underwent laparotomy without the formation of mechanical ileus and peritonitis. For histological examination, fragments of the intestinal wall were sampled 1 cm above the site of the obstruction with mechanical ileus and the portion of the small intestine with peritonitis. Statistical processing was performed in an Excel package using parametric statistics methods. It was stated that with mechanical ileus purulent inflammation develops in the intestine wall beginning from the mucous membrane spreading over wall thickness which can cause its destruction within 48 hours; with dynamical ileus purulent inflammation develops in the intestine wall, it captures particularly serous and muscle layers without causing violations of mucosa cover structure and without intestine wall destruction within 48 hours. Under experimental dynamic ileus, changes in the mucous membrane were reactive in nature and consisted of manifestations of compensatory-adaptive and regenerative processes in response to a violation of the trophism of various structures of the intestinal wall.

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Тамм, Т. И., И. Г. Зульфигаров, И. Н. Мамонтов, et al. "Peculiarities of Liver Histostructure and Choledochous Duct in Partially Restored Bile Duct." Хирургия. Восточная Европа, no. 4 (December 31, 2021): 452–59. http://dx.doi.org/10.34883/pi.2021.10.4.013.

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Введение. Состояние гистоструктуры печени при полной непроходимости желчных путей достаточно полно отражено в литературе. За последние десятилетия нами не найдено публикаций, посвященных изучению динамики гистологической структуры печени и стенки холедоха при частично восстановленном токе желчи, но неустраненной причине холестаза. Цель. Определить в эксперименте динамику гистологической структуры печени и стенки холедоха при восстановленном токе желчи, но неустраненной причине полной обструкции. Материалы и методы. Моделирование было выполнено на 29 крысах линии Вистар путем выделения холедоха и его перевязки без пересечения. Животных выводили из эксперимента на 3, 7, 14, 21 и 35-е сутки, когда производили забор биоптатов печени и холедоха для изучения их гистологической структуры. Результаты. На 3-и сутки отмечены процессы деструкции гепатоцитов, одновременно с этим наблюдалась начинающаяся пролиферация желчных протоков. На 7-е сутки в 12-перстной кишке у части животных обнаружена желчь, а в печени отмечено уменьшение острого воспаления в виде снижения полнокровия сосудов и лейкоцитарной инфильтрации, а также появились признаки новообразованных желчных протоков. Процессы более полной реканализации желчных путей с восстановлением пассажа желчи начинаются с 14-х суток. На 35-е сутки у 2/3 животных восстанавливался пассаж желчи, что подтверждено ее наличием в 12-перстной кишке. В печени с 14-х по 28-е сутки стихали процессы воспаления и формировалась дольковая архитектоника с невыраженными процессами фиброза. Наиболее ярко это было представлено на 35-е сутки исследования. Одновременно с этим в стенке холедоха начиная с 3-х суток выше лигатуры отмечены морфологические изменения в виде острого катарального воспаления с переходом во флегмонозное. На фоне процессов воспаления в стенке холедоха происходят процессы восстановления желчетока за счет появления вновь образованных желчных протоков. К 35-м суткам у животных с наличием желчи в 12-перстной кишке выявлена правильная дольковая архитектоника в структуре печени с невыраженным процессом фиброза. В стенке холедоха, расположенного выше места препятствия, в эти сроки на фоне уменьшения воспаления и слабого фиброза выявлено множество новообразованных желчных протоков. Выводы. При полной обструкции желчных путей в эксперименте в печеночной дольке происходят некротические изменения, которые регрессируют по мере устранения холестаза. Восстановление тока желчи при неустраненной причине ведет к нормализации гистологической структуры печени. В стенке холедоха при полной его обструкции развивается катаральное с переходом в флегмонозное воспаление. С течением времени у животных происходит реканализация холедоха за счет вновь образованных желчных ходов в его стенке. Introduction. The state of the histostructure of the liver with complete obstruction of the biliary tract is fully reflected in the literature. Over the past decades, we have not found publications devoted to the study of the dynamics of the histological structure of the liver and the wall of the common bile duct with partially restored bile flow, but the cause of cholestasis has not been eliminated. Purpose. To determine in an experiment the dynamics of the histological structure of the liver and the wall of the common bile duct with a restored bile flow, but not eliminated the cause of complete obstruction. Materials and methods. Modeling was performed on 29 Wistar rats by isolating the choledochous duct and ligating it without crossing it. The animals were taken out of the experiment on days 3, 7, 14, 21 and 35, when biopsies of the liver and common bile duct were taken to study their histological structure. Results. On the 3rd day, the processes of destruction of hepatocytes were noted, at the same time, the beginning proliferation of the bile ducts was observed. On the 7th day, bile was found in the duodenum 12 in some animals, and a decrease in acute inflammation in the form of a decrease in vascular congestion and leukocyte infiltration was noted in the liver, as well as signs of newly formed bile ducts. The processes of a more complete recanalization of the biliary tract with the restoration of the passage of bile begin from 14 days. On the 35th day, bile passage was restored in 2/3 of the animals, which was confirmed by its presence in the duodenum 12. In the liver from 14 to 28 days, inflammation processes subsided and lobular architectonics with unexpressed fibrosis processes were formed. This was most vividly presented on the 35th day of the study. At the same time, in the wall of the common bile duct, starting from 3 days above the ligature, morphological changes were noted in the form of acute catarrhal inflammation with a transition to phlegmonous. Against the background of the processes of inflammation in the wall of the common bile duct, the processes of restoration of the bile duct occur due to the appearance of the newly formed bile ducts. By the 35th day, animals with bile in the duodenum 12 showed the correct lobular architectonics in the structure of the liver with an unexpressed process of fibrosis. In the wall of the common bile duct, located above the place of the obstacle, during these periods, against the background of a decrease in inflammation and weak fibrosis, a lot of newly formed bile ducts were revealed. Conclusions. With complete obstruction of the biliary tract in the experiment, necrotic changes occur in the hepatic lobule, which regress as cholestasis is eliminated. Restoration of bile flow with an unresolved cause leads to the normalization of the histological structure of the liver. In the wall of the common bile duct, with its complete obstruction, catarrhal develops with a transition to phlegmonous inflammation. With the passage of time in animals, the common bile duct is recanalized due to the newly formed bile ducts in its wall.

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Dmitrik, Irina, Evgeny Chernobai, Elena Sinyakina, Viktor Konoplev, and Natalia Аgarkova. "HISTOSTRUCTURE OF THE SKIN OF FINE-WOOL SHEEP BREEDS OF DIFFERENT AGES." Agrarian Bulletin of the North Caucasus 55, no. 3 (2024): 24–28. https://doi.org/10.31279/2949-4796-2024-3-55-24-28.

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Yerofeyeva, A. M. V., E. V. Fedorova, S. N. Rjabceva, and A. Yu Molchanova. "Comparative evaluation of the effectiveness of systemic and local administration of mesenchymal stem cells in experimental neuropathy." Health and Ecology Issues 20, no. 2 (2023): 65–71. http://dx.doi.org/10.51523/2708-6011.2023-20-2-09.

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Objective. Compare the effectiveness of systemic and local administration of adipose-derived mesenchymal stem cells (ADMSC) at a dose of 1х106 cells/kg on nociceptive sensitivity to mechanical and thermal stimuli in rats and changes in histostructure of sciatic nerve and surrounded tissues of affected hind paw in experimental model of peripheral neuropathy of sciatic nerve.Materials and methods. 26 male Wistar rats were used to perform a model of peripheral neuropathy by axotomy of the sciatic nerve. On the 7th day, the experimental animals underwent systemic or local transplantation of ADMSC at a dose of 1x106 cells/kg. Nociceptive responses to mechanical and thermal stimuli were assessed for 90 days, and the histostructure of the sciatic nerve and surrounding tissues was analyzed after systemic and local transplantation of ADMSC.Results. Systemic administration of ADMSC at a dose of 1x106 cells/kg to rats with sciatic nerve axotomy increased the mechanical withdrawal threshold (MWT) by 17.1% and had no effect on the thermal withdrawal latency (TWL). Local administration of ADMSCs in an equivalent dose contributed to the full recovery of the MWT and TWL by the 21st day of the experiment, as well as suppressed the inflammatory reaction in the soft tissues of the operated hind paw of experimental animals.Conclusion. Intramuscular administration of ADMSC into the area of sciatic nerve axotomy of rats was significantly more effective than systemic administration of an equivalent dose of a cell transplant. This method of administration is more appropriate for further studies of the mechanisms of antinociceptive and reparative effects of ADMSCs.

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Reznichenko, Aleksey A., Ludmila V. Reznichenko, Аlexandr А. Nishanbayev, and Vasily I. Dorozhkin. "THE EFFECT OF ANTIOXIDANTS ON THE NATURAL RESISTANCE AND HISTOLOGICAL STRUCTURE OF THE LIVER OF BROILER CHICKENS." Problems of veterinary sanitation, hygiene and ecology 1, no. 45 (2023): 95–100. http://dx.doi.org/10.36871/vet.san.hyg.ecol.202301014.

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In our work, we studied the effect of antioxidants on the natural resistance of broiler chickens, as well as their effect on the histostructure of the liver. Studies have shown that hypoxene and heptran increase the bactericidal activity of blood serum and phagocytic activity of pseudoeosinophils. In addition, the studied drugs had a positive effect on the restoration of the structure of liver cells. At the end of the experimental period after poultry slaughter, there were no signs of fatty liver degeneration in chickens of the experimental groups, which indicates the hepatoprotective effect of hypoxene and heptran.

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Romanovych, M. M., O. I. Vishchur, B. M. Kurtyak, I. O. Matiukha, D. I. Mudrak, and M. S. Romanovych. "Influence of probiotics on histostructure of the bursa of Fabricius in broiler chickens." Journal for Veterinary Medicine, Biotechnology and Biosafety 5, no. 1 (2019): 5–9. http://dx.doi.org/10.36016/jvmbbs-2019-5-1-1.

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The article deals with the data on the influence of probiotic preparation BPS-44 and 2% yeast Saccharomyces cerеvisiae on the histostructure of tissues of the cloacal sac (bursa of Fabricius) of broiler chickens. The conducted histological researches have shown that in chickens of the control group at the end of the experiment in the cloacal sac were revealed intraepithelial microcystic cavities, but in the medullary substance of the lymph nodes, necrotic changes are recorded and glandular structures are formed, indicating an insufficient level of lymphopoiesis. The use of these probiotic preparations to broilers from the experimental groups during the period of their growth in the ration caused a normalizing effect on the morphostructure of the cloacal sac and, in particular, on the action of 2% yeast Saccharomyces cerеvisiae. It is evidenced by the absence of the formation of microscystic cavities in the epithelial layer of the cloacal sac (signs of slowing down the processes of age involution). In this case, the lymph nodes are numerical, the division into cortical and medullar substance is clear, they were densely populated with lymphoid elements, indicating the possibility of forming an adequate immune response in the poultry of this group.

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Sergiyenko, L. Yu, L. A. Bondarenko, A. R. Gevorkyan, N. N. Sotnik, A. N. Cherevko, and T. V. Mishchenko. "CHANGES IN HISTOSTRUCTURE AND LEPTIN PRODUCING IN ADIPOSE TISSUE DURING LIGHT-INDUCED HYPOPINEALISM." Problems of Endocrine Pathology 54, no. 4 (2015): 61–70. http://dx.doi.org/10.21856/j-pep.2015.4.08.

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In the literature of recent years it was widely discussed the issue of violation of the light mode as a risk factor for the formation of obesity — one of the leading symptoms of metabolic syndrome and type 2 diabetes. However, until the real time, the effect of the long round-the-clock illumination of different duration on histological and leptinproducing activity of adipose tissue remains unclear. Studies of the dynamics of weight indicators, histological characteristics and the level of leptin in the blood plasma of rats subjected to long round-the-clock illumination, for 3, 5 and 10 months, led to the conclusion that, originally, animals subjected to long round-the-clock illumination observed an activation of hyperplastic processes in adipose tissue and increasing of its leptinsynthesizing activity. Long round-the-clock illumination as an inducer of expressed hypopinealizm is the cause hypoplasia of adipose tissue, a sharp drop of its cytokineproducing function and the development of its nonspecific inflammation.

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Sokulskyi, I. M., L. P. Goralskyi, N. L. Kolesnik, O. F. Dunaievska, and N. L. Radzikhovsky. "Histostructure of the gray matter of the spinal cord in cattle (Bos Taurus)." Ukrainian Journal of Veterinary and Agricultural Sciences 4, no. 3 (2021): 11–15. http://dx.doi.org/10.32718/ujvas4-3.02.

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The scientific article presents the results of investigating the spinal cord`s morphology of a domestic bull (Bos Taurus). Data on the histo- and cytostructure of the spinal cord are given according to the results of histological, neurohistological, and morphometric studies. For their implementation, the selected material (spinal cord n = 8) was subjected to fixation in 10–12 % neutral formalin solution, followed by pouring into paraffin. Histological sections were made from paraffin blocks on a sliding microtome MS-2 with a thickness of not more than ten μm. Staining of sections with hematoxylin and eosin, according to Van Gieson's methods, as well as neuro-histological methods of impregnation of nerve tissue with silver nitrate according to the Bilshovskym-Gross method, was used for the morphometric studies, investigating the morphology of the cell, conducting and obtaining the review histological preparations. The histostructure of the spinal cord, the localization of neurons in the gray matter, and morphometric studies of structural elements were examined on histological specimens by light microscopy. The entire experimental part of the research was conducted following the requirements of the international principles of the "European Convention for the Protection of Vertebrate Animals for Experimental and Other Scientific Purposes" (Strasbourg, 1986). The spinal cord, medulla spinalis, an organ of the central nervous system of vertebrates, is located in the spinal canal. The spinal cord is protected externally by soft, arachnoid, and hard meninges. The space between the membranes and the spinal canal is filled with cerebrospinal fluid. It is well known that groups of multipolar nerve cells with the same functional value form the nuclei of the gray matter of the spinal cord. According to the results of our histological studies, a pronounced differentiation of nerve cells, which have different shapes and sizes. Among them are large, medium, and small nerve cells. The shape of nerve cells is different, which, in turn, depends on their location in certain areas of the gray matter of the spinal cord and the size of the cell. In general, there are multifaceted, stellate, spindle-shaped, elongated, rounded, and oval neurons. Small nerve cells have an oval or round, less often – irregularly rounded shape, medium – round, oval, spindle-shaped. Large nerve cells are dominated by a multifaceted shape with distinct processes. The nuclei of large nerve cells, in most cases, have a rounded shape, less often – oval, mostly in the center of the cells, seldom – eccentrically. According to the results of morphological studies, it is noted that the neurons of the gray matter of the spinal cord have different shapes and sizes. Consequently, in the gray matter, small cells are the highest quantity (47.91 ± 0.32 %) of the total number of nerve cells. The second place is occupied by average neurons (33.70 ± 0.46 %). The large cells are detected in the smallest amount (18.37 ± 0.50 %).

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Seliukova, N. Yu, Yu B. Laryanovskaya, G. V. Storozhenko, and V. S. Kharchenko. "HISTOSTRUCTURE OF THE OVARIES OF PUBERTY RATS BORN TO MOTHERS WITH FETOPLACENTAL INSUFFICIENCY." Bulletin of Problems Biology and Medicine 2, no. 1 (2020): 290. http://dx.doi.org/10.29254/2077-4214-2020-2-156-290-295.

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Polskiy, Vsevolod S., Aleksey A. Reznichenko, Svetlana N. Vodyanitskaya, Roman V. Shcherbinin, and Мarya S. Gurova. "PHARMACOLOGICAL EFFICACY OF LIPOFOS IN HEPATOSIS OF LAYING HENS." Problems of veterinary sanitation, hygiene and ecology 2, no. 50 (2024): 261–66. http://dx.doi.org/10.36871/vet.san.hyg.ecol.202402013.

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Fats and oils are one of the most important components of compound feed for poultry. Their importance is determined by the ability to accumulate energy in the body, as lipids are structural components of biological membranes. Therefore, it is necessary to use lipid feed additives and phospholipid preparations. Optimal doses of the phospholipid preparation – lipofos, a by-product of soy lecithin production, have been established for laying hens. Hepatoprotective properties of the studied drug were established, which are manifested by the restoration of the histostructure of bird liver cells. An increase in egg production of laying hens and an improvement in product quality were also noted.

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Basalai, A. A., T. A. Mityukova, T. E. Kuznetsova, et al. "Effect of diet-induced obesity and non-drug options of its correction on the functional and morphological liver characteristics in female Wistar rats." Proceedings of the National Academy of Sciences of Belarus, Medical series 21, no. 3 (2024): 183–93. http://dx.doi.org/10.29235/1814-6023-2024-21-3-183-193.

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A nonalcoholic fatty liver disease is one of the unfavorable consequences of obesity. However, experimental studies on the mechanisms of this pathology development are being carried out mainly on male rodents, and the data on the development of fatty hepatosis in females are insufficient.The aim of the study was to investigate the effect of diet-induced obesity and non-drug options for its correction on the morphological liver characteristics and liver metabolic parameters in female Wistar rats. Experiments were conducted on sexually mature female Wistar rats and included the study of morphological and biochemical parameters of the liver functional state in animals kept on standard diet (StD, 16 weeks), on a high-calorie diet (HCD, 16 weeks) when switching to a standard diet (HCD/StD, 8/8 weeks), when the physical activity in the form of treadmill running was included (StD + running, HCD + running and HCD/StD + running, 8/8 weeks).Long-term use of HCD in female rats caused visceral obesity, liver fatty dystrophy with disruption of organ histoarchitectonics, shifts in hepatic metabolism and increased lipid peroxidation. Correction of diet-induced obesity by switching to StD led to a complete or partial normalization of the studied indices. In the “HCD + running” group, metabolic disorders are often more pronounced than in the “HCD” group. The transition to HCD/StD + running promoted the most complete restoration of metabolism and histostructure of the liver with regeneration signs of the organ.Thus, an optimal correction of visceral obesity, fatty liver dystrophy and its metabolism is impossible without diet normalization in female Wistar rats. An additional regenerating effect with respect to the liver histostructure is achieved with a combined variant of correction ‒ transition to a balanced diet and moderate physical activity.

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Dmitrik, Irina, Evgeny Chernobai, and Elena Sinyakina. "HISTOSTRUCTURE OF THE SKIN OF FINE-WOOL SHEEP BREEDS WITH DIFFERENT FINENESS OF WOOL." Agrarian Bulletin of the North Caucasus 54, no. 2 (2024): 17–22. https://doi.org/10.31279/2949-4796-2024-2-54-17-22.

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The article presents an analysis of histological indices of the skin of fine-wool sheep breeds with different wool fineness. 75 % of the Manych merino rams had a wool fiber diameter of up to 23.09 μm (quality 64), 16.7 % – up to 17.95 μm (quality 80) and 8.3 % – 19.09 μm (quality 70). A similar dependence was observed in Stavropol merino sheep 53.8 % – up to 20.41 microns (70 quality), 30.8 % – up to 22.06 microns (64 quality), 15.4 % – up to 24.02 microns (60 quality) and Russian meat merino 54.5 % – up to 20.53 microns (70 quality), 36.4 % – up to 22.74 microns (64 quality), 9.1 % – 24.6 microns (60 quality). The highest density of follicles was observed in sheep with 70 wool quality, rather than in sheep of 64 and 60 quality. Sheep with wool of 70 and 80 quality (17.37–20.53) surpassed peers of 64 and 60 quality in the total density of volost follicles of Manych merino by 26.6 pcs. or 20.8 %, Stavropol – 32.6 pcs., Russian meat merino – 23.9 pcs. By the number of secondary follicles – by 80.4 pcs, 59.6 pcs, 40.7 pcs. accordingly. The density of the hair follicles in the skin of the rams under study has a certain tendency – with an increase in the tone of the wool fiber, the density of the hair follicles increases, also, the thinner the skin, the thicker the wool, also, this can be seen in the presented drawings.

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Полковенко, Ольга Владимировна. "Histostructure changes in proxymal and distal metaphyses of white rats' femoral bones under experimental hypokinesia." ScienceRise 3, no. 1 (3) (2014): 31. http://dx.doi.org/10.15587/2313-8416.2014.27550.

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Samborska, I. A. "Changes in the histostructure of the lungs of old rats under conditions of persistent hyperhomocysteinemia." Biomedical and Biosocial Anthropology, no. 41 (December 28, 2020): 41–45. http://dx.doi.org/10.31393/bba41-2020-07.

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To date, homocysteine has been found to be an important biomarker of bronchopulmonary pathology, including COPD. The increase in its concentration in the blood plasma causes the start of free radical processes and the production of reactive oxygen species, which activate lipid peroxidation in lung tissue. In addition, the activation of endoplasmic reticulum stress with increasing homocysteine levels is the main reason for triggering apoptosis of alveolocytes. The aim of the research is to study the features of lungs histostructure in old rats under conditions of hyperhomocysteinemia. The experimental study was performed on 20 white nonlinear old (24-26 months) male rats. During the experiment, the animals were divided into two groups – control and experimental. Simulation of the state of persistent hyperhomocysteinemia was achieved by administering to rats of experimental group thiolactone homocysteine at a dose of 200 mg/kg body weight intragastrally for 60 days. Histological specimens were studied using an SEO CCAN light microscope and photo-documented using a Vision CCD Camera with an image output system from histological specimens. In elderly animals under conditions of experimental hyperhomocysteinemia develop severe destructive-degenerative changes in the lungs. Significant remodeling of the vascular bed, bronchi, inflammatory manifestations, enlargement of dis- and atelectasis and emphysematically altered alveoli of the respiratory lungs, violation of the alveolar walls, with the release of blood cells into the alveolar space and the formation of small diapedetic hemorrhages. The development of perivascular, peribronchial and interstitial sclerosis is characteristic.

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Shchudlo, N. A., T. N. Varsegova, and M. M. Shchudlo. "Healing and histostructure of vascularized fasciocutaneous flaps under the conditions of brain tissue lyophilizate microinjections." Genij Ortopedii 23, no. 4 (2017): 471–75. http://dx.doi.org/10.18019/1028-4427-2017-23-4-471-475.

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MUSALAEV, Kh Kh, R. A. ABDULLABEKOV, and P. M. MAGOMEDOVA. "FEATURES OF THE HISTOSTRUCTURE OF THE SKIN OF THE ARTLUKH MERINO NEW BREED YOUNG EWES." Daghestan GAU Proceeding, no. 1 (2023): 123–27. http://dx.doi.org/10.52671/26867591_2023_1_123.

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Elkomy, Hassan S., Ivan I. Kochish, Olga V. Myasnikova, and Elena А. Prosekova. "Microflora and histostructure of the intestine of laying hens under the influence of prebiotic “Butifour F”." Veterinariya, Zootekhniya i Biotekhnologiya 5, no. 102 (2022): 13–24. http://dx.doi.org/10.36871/vet.zoo.bio.202205002.

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The aim of the research is to study the effect of a prebiotic (Butifour F) on the microflora of chickens’ caecum and the histostructure of the jejunum and proximal portion of the caecum in laying hens of the Lohmann Brown cross. To solve this problem in the conditions of the vivarium of the International Laboratory of Molecular Genetics and Poultry Genomics, Department of Animal Hygiene and Poultry A. K. Danilova, MVA by K. I. Skryabin, this experiment was carried out. The diet of laying hens of the experimental groups differed from the control one by introducing a prebiotic (Butifour F) at dosages of 500 g/t, 750 g/t and 1000 g/t of feed, respectively. It was found that birds of the 2nd and 3rd treatment group (TG), the proportion of phylum Actinobacteria significantly increased by 255,6 и 172,2 %, respectively, including bacteria of the order Bifidobacteriales – by 2.7 and 1.13 times. The feed additive contributed to an increase in the number of the Lactobacillaceae family by 2,4 и 1,9 times and reduced the total amount of pathogenic and undesirable microflora by 44 and 34%. In the jejunum, there is no effect of the drug on morphometric parameters, and in the proximal part of the caecum in chickens 1st and 2nd TG, an increase in the layer of villi by 35.8% and 28.7% (P≤0.001) was noted. Also, in the studied parts of the intestines of experimental birds, a high preservation of the epithelial lining and a better development of the lymphoid tissue are visible. Thus, the drug used contributes to the normalization of the intestinal microflora and has a protective effect on the intestinal mucosa.

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Khrabko, M. I., R. S. Fedoruk, Yu V. Martyn, U. I. Tesarivska, and M. I. Shumska. "Histostructure of internal organs in female rats of first generation for different doses of germanium citrate." Animal Biology 19, no. 4 (2017): 73–82. http://dx.doi.org/10.15407/animbiol19.04.073.

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1Vvedenskyi, D. B., N. O. Volkova, N. O. Ashukina, M. S. Yukhta, and A. M. Goltsev. "DYNAMICS OF HISTOSTRUCTURE OF CARTILAGE TISSUE AND HEMATOLOGICAL INDICATORS OF BLOOD IN RATS WITH ADJUVANT ARTHRITIS." Bulletin of Problems Biology and Medicine 1, no. 3 (2023): 386. http://dx.doi.org/10.29254/2077-4214-2023-3-170-386-394.

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Meyramov, G. G., K. D. Kohnert, A. S. Shaybek, O. N. DuPont, and A. G. Abdraimova. "Diabetogenic Metabolits of Tryptophan." Bulletin of the Karaganda University “Biology medicine geography Series” 84, no. 4 (2024): 44–55. http://dx.doi.org/10.31489/2016bmg4/44-55.

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The analysis of results investigations of mechanisms of diabetogenic activity of metabolits of abnormal tryptophan metabolism as Xanthurenic acid (XA) are presented in review. Among more than 30 diabetogenic chemicals widely known today XA only is formed in animals and elderly human as result of disturbances of tryptophan metabolism. The influence of XA on histostructure of pancreatic islets and on insulin content in B-cells as mechanisms of diabetogenic action and of its prevention are investigated by authors. It was showed that Xanthurenic acid induced diabetes determined by: direct damage of B-cells by Xanthurenic acid accom-panied by marked histological changes in islets as destruction and necrosis of B-cells, marked decreasing of insulin content in cytoplasm of cells; by forming of complex XA-insulin that result overstrain of B-cells; by alteration of islet’s capillaries and of blood microcirsulation.

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Abikenova, Fatima S., Gabit Meyramov, Saule Zhautikova, et al. "Investigation of Antidiabetogenic Effect of the Iodine-Selenium Concentrate in Animals with Chronic Alloxan Diabetes of Varying Severity." Open Access Macedonian Journal of Medical Sciences 9, A (2021): 535–40. http://dx.doi.org/10.3889/oamjms.2021.5873.

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BACKGROUND: The diabetogenic effect of alloxan is known is determined by ability to stimulate lipid peroxydation processes in B-cells of the pancreas. AIM: to investigate of the possible antidiabetic action of long time prolonged of Iodine-Selenium concentrate action in rats with alloxan diabetes. METHODS: Reproduction of experimental alloxan diabetes was carried out in rats by a single intravenous injection of alloxan 35-43 mg / kg body weight. The “iodine-selenium” concentrate was administered per os through a tube at the rate of 1.25 ml / 100 g of the concentrate. In experimental animals with mild and heavy diabetes mellitus, the level of glucose in the blood was assessed, products of LPO-AOD; the state of the histostructure of the pancreas and of insulin content in B cells were studied using of aldehyde fuchsin and diethylpseudoisocyanine methods. RESULTS: Long time prolonged administration of the “iodine-selenium” concentrate (60 days) to animals with mild experimental diabetes mellitus is accompanied by a significant decrease in blood glucose levels by 1.89 times compared to the control (p ˂ 0.05) and of LPO within normal values as by increase of the level of glutathione peroxidase (GPO) by 2.23 times compared with the initial (p˂ 0.01), by prevention of the development of histological changes in pancreatic islets and a slight decrease of insulin content in B-cells. Under similar experimental conditions in animals with severe alloxan diabetes, the level of glycemia significantly decreased from 20.23 ± 2.15 mmol / l to 12.39 ± 1.52 mmol / l as of the level of diene conjugates of erythrocytes and plasma, as decrease of ketodienes, MDA of plasma and in erythrocytes and primary lipid peroxidation products, while remaining elevated, despite an increase in GPO by 50.0% compared with control (p˂0.05) in the presence of histological changes in the pancreatic islets as in experimental diabetes.  CONCLUSION: The antidiabetic effect of the “iodine-selenium” concentrate in rats with mild alloxan diabetes on the level of glycemia, LPO - AOD and state of the histostructure of the pancreas and the content of deposited insulin in pancreatic B-cells, is probably due to antioxidant effect of selenium to stimulate activity of glutathione blocking lipid peroxide and hydrogen peroxide in alloxan diabetes mellitus.

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Dmitrik, I. "The correlation of the main qualitative characteristics of wool with the histological structure of the skin." Glavnyj zootehnik (Head of Animal Breeding), no. 5 (May 1, 2020): 39–45. http://dx.doi.org/10.33920/sel-03-2005-05.

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A comparative evaluation of the study of the main traits of wool with indicators of the histostructure of the skin of rams has been shown that the fat content in wool averaged 13,1 %. The correlation coefficient between the percentage of pure wool yield and the amount of fat was 0,38. A negative correlation between the amount of wool shorn, the yield of pure fiber, and the length of the wool has been was obtained with the amount of sweat in the wool (P < 0,01). This suggests that the reduction of the sweat part in the fat content will occur to a certain extent due to indirect selection for wool productivity. As the level of the comprehensive evaluation has decreased, the wool thinned by an average of 0,98 microns. The difference in the length of the wool of rams of the 1st group with average indicators was 1,3 cm, and for the amount of wool shorn and the yield of pure fiber –1,18 kg and 7,17 %, respectively. A negative correlation (r = –0,50) has been obtained in rams with the thinness of 23,0–25,0 microns compared to herdmates with 18,0–20,0 microns when studying the correlation between follicle density and the primordial follicle/secondary follicle ratio. The narrower the DPF/DSF ratio the thinner the coat, and vice versa animals with the narrower ratio (0,98) have been characterized by a more balanced fiber. The correlation coefficient between the thinness of wool and the diameter of the secondary fiber was 0,42. With increasing thickness of the skin and especially its pilar layer the hair becomes shorter. Rams with a hair length of 10 cm have 19,2 % thicker skin and 23 % thicker pilar layer. There is a tendency to thicken the skin and pilar layer in rams of the 3rd group. Animals with the total follicle density of 80,0 pcs/mm[sup]2[/sup] or higher have 8,0 % less thickness compared to their herdmates who have 50,0 follicles per mm[sup]2[/sup] . Thus, the significant correlation has been found not only between the traits of fleece and wool, but also indicators of skin histostructure. This confirms the need to evaluate the fleece for the entire range of various properties of wool and skin histogenesis.

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Budnik, T. S., and S. V. Guralska. "Cyto- and histoarchitectonics of the chicken spleen in the post-vaccination period." Ukrainian Journal of Veterinary and Agricultural Sciences 5, no. 3 (2022): 13–17. http://dx.doi.org/10.32718/ujvas5-3.03.

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One of the main functions of the spleen is participation in many immunological processes, protecting the body from various harmful agents. It is a secondary organ of lymphopoiesis and the only organ of immunogenesis, which provides immune control of blood and detects genetically foreign agents in it, and performs the role of a biological filter. Therefore, the Study of its histo-architectonics has theoretical and practical significance. The histostructure of the spleen of chickens has significant differences, particularly the absence of trabeculae, a small amount of connective tissue based around large vessels. The structure of the spleen of one-day-old vaccinated and non-vaccinated chickens is not formed, as there is no differentiation of the white pulp from the red pulp, which is related to the biological features of the chickens' body. According to our research, the presence of lymphoid nodules is observed for the first time in the 25-day age of the vaccinated group chickens. According to morphometric studies, it was established that their number was 2.33 ± 0.42 pcs. Comprehensive farm vaccination programs include ten vaccinations of chickens up to 100 days of age. Under the influence of multiple antigenic stimulations in the following age periods of a 50-day-old bird (after six vaccinations: twice against infectious bronchitis and infectious bursal disease, once against Marek's disease and Newcastle disease), the 75-day (after nine times vaccination), 100-day (after ten times vaccination) number and sizes of lymphoid nodules, as well as periarterial lymphoid sheaths and periellipsoid lymphoid sheaths increased concerning chickens of the control group. Our research established that the histostructure of the spleen of one-day-old chickens of the experimental and control groups is incomplete. The bird's spleen, a peripheral organ of immune protection, is formed at 25 days. However, chickens are vaccinated twice (against Marek's disease and infectious bronchitis) in the incubator when they are less than one day old, and 90% of the planned vaccinations are completed by the age of 75 days. Therefore, studying morphological changes in the spleen of birds of different ages can be an essential tool for re-evaluating preventive treatment protocols in modern poultry farming.

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Journal articles on the topic 'Histostructure'

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