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Dissertations / Theses on the topic 'HIV Infections Hepatitis C'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Falconer, Karolin. "HIV-1/HCV co-infection immunity and viral dynamics /." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-762-7/.

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2

Fialho, Renata. "Neuropsychiatric manifestations of hepatitis C treatment in HIV/HCV co-infection." Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/71260/.

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Hepatitis C (HCV) infection is associated with high rates of mortality and morbidity. Interferon alpha based treatment for HCV offers a good rate of viral clearance, however the associated neuropsychiatric side effects increase the risk of treatment interruption and disease progression. The HIV/HCV coinfection is of particular interest due to association with higher rates of HCV treatment side effects and earlier treatment discontinuation when compared with HCV mono-infection. Therefore, the aim of the thesis was to further explore the effect of coinfection on mood and cognition and how HCV in

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3

Harris, Kathryn Ann. "Genetic diversity and evolution of hepatitis C virus." Thesis, Open University, 2000. http://oro.open.ac.uk/58053/.

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Inter- and intra-host Hey variation was investigated. First. a polymerase chain reactionrestriction fragment length polymorphism procedure was used to assign genotypes and subtypes to Hey infecting 567 individuals (comprising haemophilia patients, blood donors, intravenous drug users, attenders of antenatal and genito-urinary medicine clinics and chronic liver disease patients) from England and Wales. The majority of infections were associated with types 3a, 1 a and 1 b, and genotype distributions were generally similar in different sub-populations. Only 1 % of individuals were identified as b

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4

Herreru-MartiÌnez, Esteban. "Hepatitis C and HIV co-infection in patients with haemophilia." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404936.

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5

Burke, Stephanie. "Generalized Impairment of CD8+ T-cells in HCV Mono- and HIV-HCV Co-infection." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32770.

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Chronic hepatitis C virus (HCV) infection has global effects on the immune system. CD8+ T-cells, responsible for viral clearance and control, are dysfunctional for as yet unknown reasons. It is hypothesized that IL-7 signaling pathway deficiencies contribute to this impairment. Blood-derived CD8+ T-cells in chronic HCV mono- and HIV-HCV co-infection had lower IL-7-induced activation of STAT5 and production of Bcl-2, and lower proliferation in co-infection, compared to controls. Lower Bcl-2 production was also associated with increased fibrosis. These changes were independent of the IL-7 recep

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6

Yao, Felix Caspar. "Investigation on the risk of viral infection in musculoskeletal grafts." University of Western Australia. School of Surgery, 2010. http://theses.library.uwa.edu.au/adt-WU2010.0068.

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[Truncated abstract] Around 50,000 hip and knee replacements are performed every year in Australia and this number has been increasing by around 13% annually since 1998 (Transplantation Society 2006). The incidence and number of revision surgery has increased by a similar proportion. Autogenous bone or allograft is still the gold standard grafting material and is currently used in a variety of reconstructive surgical procedures. The use of any allograft material carries with it the risk of transfer of disease from donor to recipient. These tissues can transmit the same viral and bacterial infe

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7

Ogawa, Lisa Marie Fink. "Substance Use Experiences and Hepatitis C Treatment Decision-Making Among HIV/HCV Co-infected Adults: A Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsn_diss/3.

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Hepatitis C virus (HCV) infection affects between 150,000 to 300,000 human immunodeficiency (HIV) positive adults in the US (Alter et al., 1999; Sherman, Rouster, Chung, & Rajicic, 2002). The majority of co-infected adults (50%-90%) have acquired HCV through substance abuse (Centers for Disease Control [CDC], 1998; CDC, 2006b). A patient's decision to begin HCV treatment is not straightforward. HCV evaluation and treatment involves a significant amount of time, energy, effort, and compliance on the part of the patient. There is limited information on how adults with HCV mono-infection make dec

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8

Matsukura, Motoi. "Highly active anti-retroviral therapy and liver mitochondrial toxicity in human immunodeficiency virus / hepatitis C virus co-infection." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2517.

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Background: A third of HIV-infected patients are co-infected with HCV in the developed world, and more of co-infected patients than ever before are dying because of liver related diseases today. Drug-related hepatotoxicity is a growing concern among human immunodeficiency virus (HIV) / hepatitis C virus (HCV) co-infected population. Nucleotide analogues containing HIV antiretroviral therapy, namely highly active anti-retroviral therapy (HAART), can induce mitochondrial toxicity. However, little is known about the effect of nucleotide analogues on the liver at the cellular and molecular level,

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9

Malm, Kerstin. "Diagnostic strategies for blood borne infections in Sweden." Doctoral thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-44303.

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10

Chen, Yang. "An Epidemiological Study of Hepatitis C Virus Infection Among U.S. Population." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etd/3105.

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Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United States (U.S.). The largest increases of incidence for HCV infection are reported in the Appalachian region. This study aimed to 1) examine the prevalence and trends of HCV infection in the U.S. from 1999 to 2012; 2) investigate barriers to HCV infection treatment in Northeast Tennessee and the U.S.; and 3) study characteristics and risk factors for HIV-infection and HCV-infection in Northeast Tennessee. In the U.S., data were obtained from the National Health and Nutrition Examination Survey (NHANES) 1999-

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11

Maerrawi, Ilham El. "Desenvolvimento de um estudo piloto de uma pesquisa que visa identificar fatores de risco associados às infecções pelo HIV, hepatites B, C e sífilis em população carcerária." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5137/tde-09122009-174537/.

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Introdução: A população confinada é um segmento exposto a certas situações que aumentam sua vulnerabilidade frente às doenças sexualmente transmissíveis. Infecções pelo HIV, hepatites B e C e sífilis encontram no sistema prisional um ambiente favorável às suas propagações. Estudos em população confinada são cercados de entraves tanto burocráticos como relacionados com a ética e segurança. Assim, assume grande importância um estudo - piloto para, entre outras coisas, identificar pontos prós e contras que possam surgir durante a execução do estudo principal. Objetivo: Desenvolver um estudo pilot

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12

Northfield, John. "Aspects to T-cell phenotype during infection with HIV, CMV and Hepatitis C virus." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:283098ce-e24d-4099-8826-07dcc75381f2.

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This work concerns itself with understanding the organisation of cellular immune responses to three major human pathogens - HIV, CMV and Hepatitis C (HCV). Each was studied to form three projects, each undertaken with a different approach - arrived at independently - and largely owing their origins to opportunity and circumstance as much as design. Each project led to exploration of a particular aspect of T-cell phenotype (that is the expression of particular molecular markers on T-cells) and its’ broader biological significance. I found that T-cell phenotype was strongly linked to the magnitu

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13

Danta, Mark. "Acute hepatitis C infection in HIV co-infection : epidemiology, natural history and the host-viral responses." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445482/.

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Aim: To analyse the epidemiological, clinical and immunological aspects of a recent epidemic of acute HCV in HIV co-infected individuals.;Methods: The epidemiology was characterised using combined molecular and clinical studies. A phylogenetic analysis of the E1/E2 region of the HCV genome was performed to determine HCV transmission. Transmission risk factors were then explored in a multicentre case-control study. Data was collected on the early clinical course of HCV in HIV. Longitudinal cell-mediated responses to HCV and HCV evolution were studied with PBMCs and serum collected during the ac

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14

Yonkers, Nicole L. "Toll-like Receptor Tolerance in Dendritic Cells During Hepatitis C and HIV Infections: Collapsing the Bridge Between Innate and Adaptive Immunity." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1298412448.

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15

Masembe, Melissa. "The effectiveness of the Stockholm needle exchange programme : Does the Stockholm needle exchange programme control HIV, Hepatitis B, and Hepatitis C in intravenous drug users?" Thesis, Södertörns högskola, Institutionen för naturvetenskap, miljö och teknik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-38802.

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BACKGROUND: The needle exchange programme (NEP) started in Sweden in 1986 in Lund and shortly after in Malmo. The first NEP in Stockholm opened in spring 2013. The NEP is a service aimed at intravenous drug users (IDU) from 18 years old, with a goal of preventing the blood borne diseases, such as HIV, Hepatitis B (HBV), and Hepatitis C (HCV). With the on going HIV and Hepatitis epidemics, numerous countries around the world have adopted control strategies, such as the NEP to halt the spread of HIV, HBV, and HCV. The objective of this study was to examine if the needle exchange programme has de

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16

Moorman, Jonathan P., Matthew R. Krolikowski, Stephanie M. Mathis, and Robert P. Pack. "HIV/HCV Co-infection: Burden of Disease and Care Strategies in Appalachia." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/2766.

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Purpose of Review: The purpose of this review is to address infection with HIV and hepatitis C in the Appalachian region of the USA and the driving forces underlying this epidemic. We seek to discuss epidemiology of disease and the possible interventions to reduce incidence and burden of disease in this resource-limited area. Recent Findings: The rise of the opioid crisis has fueled a rise in new hepatitis C infection, and a rise in new HIV infection is expected to follow. Injection drug use has directly contributed to the epidemic and continues to remain a risk factor. Men who have sex with m

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17

Abdelrahman, Tamer. "Quasispecies dynamics and treatment outcome during early hepatitis C infection in a cohort of HIV-infected men." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/7402/.

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Hepatitis C virus (HCV) is emerging as one of the leading causes of morbidity and mortality in individuals infected with HIV and has overtaken AIDS-defining illnesses as a cause of death in HIV patient populations who have access to highly active antiretroviral therapy. For many years, the clonal analysis was the reference method for investigating viral diversity. In this thesis, a next generation sequencing (NGS) approach was developed using 454 pyrosequencing and Illumina-based technology. A sequencing pipeline was developed using two different NGS approaches, nested PCR, and metagenomics. T

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18

Santos, Tatiane Assone dos. "Determinação do perfil do polimorfismo da IL28B em indivíduos coinfectados pelo vírus da Hepatite C Crônica (HCV) e pelo vírus linfotrópico de células T humanas tipo 1 (HTLV-1)." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/99/99131/tde-02092013-092357/.

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O polimorfismo de IL28B foi descrito como fator importante na patogênese de infecções causadas por alguns vírus. O objetivo desta pesquisa foi avaliar se polimorfismos (SNP rs8099917 IL28B e SNP rs12979860) foram associados na presença de HAM/TSP. Métodos: O estudo incluiu 188 pacientes do Instituto de Infectologia \"Emilio Ribas\" de São Paulo, divididos em três grupos: 117 Indivíduos infectados pelo HTLV-1 (49 assintomáticos e 68 com HAM TSP), 47 Pacientes monoinfectados pelo vírus da Hepatite C (HCV) e 24 coinfectados pelo HTLV- 1 e HCV. Amostras de sangue foram coletadas, e o PBMC separado

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19

Piñero, Thiago Serafin Graña. "Caracterização dos inaptos sorológicos antes e depois da implantação do teste de ácido nucléico no Sistema Único de Saúde na Bahia." Instituto de Saúde Coletiva-ISC, 2015. http://repositorio.ufba.br/ri/handle/ri/17908.

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20

Nguyen, Truong Tam. "Co-infection VIH/VHC : développement et mise en oeuvre d’outils paracliniques pour la prise en charge dans le pays à ressource limitée et la personnalisation thérapeutique." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONT3508/document.

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Les hépatites virales constituent un enjeu majeur de santé public dans le domaine des maladies infectieuses. L’enjeu pour les prochaines années sera de mettre en œuvre des stratégies de dépistage et de de prise en charge des hépatites virales et du VIH, en particulier chez les usagers de drogue par voie intraveineuse et dans les pays à ressources limitées. Dans ce travail de thèse nous avons évalué des outils et des stratégies nouvelles pour améliorer le diagnostic et la prise en charge des infections par le VIH et le VHC dans les pays du Sud. Notre première étude porte sur l’évaluation de la

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21

Auma, Ann Winniefred Nangobi. "THE IMPACT OF DIRECT-ACTING ANTI-VIRAL THERAPY ON NAIVE CD4+ T CELL LYMPHOPENIA AND CELLULAR IMMUNE ACTIVATION IN HCV INFECTION AND HCV/HIV CO-INFECTION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1625764728651756.

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22

Neves, Andréa Carneiro de Menezes. "Co-infecções por HIV/AIDS, Treponema pallidum e Hepatites B e C entre usuários de um Centro de Testagem e Aconselhamento." Faculdade de Medicina de São José do Rio Preto, 2011. http://bdtd.famerp.br/handle/tede/118.

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Made available in DSpace on 2016-01-26T12:51:33Z (GMT). No. of bitstreams: 1 andreacarneirodemenezesneves_disset.pdf: 1064515 bytes, checksum: 4e865ffb1b9ab1ee258e16419ad23f48 (MD5) Previous issue date: 2011-07-25<br>In Sao Jose do Rio Preto-SP, the current data sum up 3,771 cases of AIDS, with a mortality rate of 1,841. The municipality of Sao Jose do Rio Preto ranks fifth in the number of AIDS cases in the state. Material and method: A retrospective study has been conducted from January 2005 to December 2009. All the HIV-1 seropositive individuals attended by the Testing and Counseling Cen

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23

Marcellin, Fabienne. "Perceptions et comportements des personnes vivant avec le VIH co-infestées par le virus de l'hépatite C." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM5001.

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En France, de 25000 à 30 000 personnes sont co-infectées par le VIH et le virus de l’hépatite C (VHC), avec des conséquences cliniques majeures. Des progrès importants ont été accomplis ces dernières années grâce au développement de nouveaux traitements contre le VHC, efficaces et très bien tolérés. En parallèle, le nombre de patients co-infectés a globalement baissé parmi les patients infectés par le VIH, mais de nouveaux groupes à risque de transmission du VHC sont apparus dans cette population, comme les hommes ayant des rapports sexuels avec d’autres hommes. Le vécu de la co-infection rest

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24

Jaouen-Jouvencel, Anne-Christine. "Variabilité du génome du virus de l'hépatite C dans la région HVR 1 du gène E2 : étude sur 22 patients co-infectés par le VHC et le VIH." Bordeaux 2, 2000. http://www.theses.fr/2000BOR23063.

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25

Shen, Hong. "Hepatitis C infection models." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05T016.

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L'hépatite C (VHC) est l'une des causes principales de maladies du foie dans le monde, qui représentent un risque élevé d'évoluer vers la cirrhose et le carcinome hépatocellulaire. Actuellement, le traitement standard de l’infection par le VHC est l'interféron pégylé-(peg-IFN) et la ribavirine. Bien que le taux de la réponse virale soutenue (RVS) au traitement se soit améliorée au cours de ces années, cette thérapie n'est pas efficace chez tous les patients. En outre, plusieurs effets secondaires toxiques, de complications et le coût élevé limitent la compliance du patient et l'efficacité du t

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26

Capot, Rullier Anne. "L'hépatite chronique virale C chez les sujets co-infectés par le virus de l'immunodéficience humaine : histologie, étude de la fibrose, détection intrahépatique du virus de l'hépatite C et comparaison avec les sujets immunocompétents." Bordeaux 2, 2001. http://www.theses.fr/2001BOR23002.

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27

Héraud, Bousquet Vanina. "Traitement des données manquantes en épidémiologie : application de l’imputation multiple à des données de surveillance et d’enquêtes." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T017/document.

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Le traitement des données manquantes est un sujet en pleine expansion en épidémiologie. La méthode la plus souvent utilisée restreint les analyses aux sujets ayant des données complètes pour les variables d’intérêt, ce qui peut réduire lapuissance et la précision et induire des biais dans les estimations. L’objectif de ce travail a été d’investiguer et d’appliquer une méthode d’imputation multiple à des données transversales d’enquêtes épidémiologiques et de systèmes de surveillance de maladies infectieuses. Nous avons présenté l’application d’une méthode d’imputation multiple à des études de

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28

Hauss, Pierre. "Epidémiologie du virus de l'hépatite C chez les personnes infectiées par le virus de l'immunodéficience humaine." Université Louis Pasteur (Strasbourg) (1971-2008), 1992. http://www.theses.fr/1992STR1M206.

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29

Shawa, Isaac Thom. "Protection from HCV infection : identification of mechanisms of resistance to HCV infection in exposed uninfected injection drug users." Thesis, University of Plymouth, 2017. http://hdl.handle.net/10026.1/10386.

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Hepatitis C virus (HCV) is a leading cause of chronic liver disease. In the developed world, injection drug use (IDU) through sharing of infected needles and other paraphernalia remains the principal risk factor for HCV transmission. Effective but expensive treatment is now possible but there remains a pressing need for a vaccine. A proportion of people who inject drugs (PWIDs) remain uninfected despite HCV exposure from a long history of sharing needles and other paraphernalia. These cases are termed exposed but uninfected (EU) and test negative for both HCV antibodies and RNA and exhibit a p

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30

Swayne, Cheryl. "Barriers to mental health services for homeless adults with Hepatitis C virus (HCV) infection." Thesis, Northern Kentucky University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3606126.

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<p> This action research study explored the complex nature of homeless adults and their perceptions of barriers to mental health services. Barriers to mental health services and a lack of resources for homeless adults are social justice issues explored in the study. The participants were homeless adults with a history of substance abuse, diagnosis of Hepatitis C (HCV) infection, and mental illness. A qualitative approach allowed for data analysis which described the experiences of homeless adults living with HCV infection. Due to the stigma assigned by HCV based on the prevalence of HCV being

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31

Arakelyan, Lilian. "Known and unknown risk factors for hepatitis B and hepatitis C infections in Ottawa." Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/26838.

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Objectives. Investigate, describe and evaluate HBV and HCV cases with known and unknown risk factors and propose modifications to the Enhanced Surveillance questionnaire based on the results of an exploratory study. Design. (1) Enhanced Surveillance database analysis; (2) Exploratory Study of hepatitis patients with unknown risk factors (URF) at the Ottawa site. Methods. Demographic and epidemiologic data analysis of HBV/HCV cases. Telephone interview with cases having unknown risk factors, using an open-ended questionnaire. Results. Medical/health care acquired, sexual transmission, healthcar

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Victoria, Marilu Barbieri. "Implicações clínicas e imunobiológicas da co-infecção HIV e vírus da hepatite C em uma população atendida na fundação de medicina tropical do Amazonas." Universidade Federal do Amazonas, 2009. http://tede.ufam.edu.br/handle/tede/3113.

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Made available in DSpace on 2015-04-20T12:31:42Z (GMT). No. of bitstreams: 1 PRE-TEXTUAL.pdf: 394027 bytes, checksum: d5e64d94f3ade196d4079ab1173940e8 (MD5) Previous issue date: 2009-06-30<br>Fundação de Amparo à Pesquisa do Estado do Amazonas<br>The global epidemic of AIDS began in 1981, the United States, and after the introduction of antiretroviral drugs to patients infected with HIV / AIDS have been given a higher survival emerged a new challenge, co-infection with the hepatitis C virus (HCV), which is already the leading cause of death in these individuals. The HCV was discovered in 1

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Deonarine, Felicia. "CD8+ T Cell Dysfunction in Chronic HCV Infection and its Association with Liver Fibrosis." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37345.

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Infection with hepatitis C virus (HCV) can cause liver damage known as fibrosis, which often leads to liver disease and hepatocellular carcinoma. The impairment of circulating, bulk (non-specific and specific) CD8+ T cells within HCV-infection, characterized by an altered phenotype and the increased expression of pro-apoptotic genes, is observed when compared to uninfected controls. The relationship between bulk CD8+ T cell function and the extent of liver damage has not been demonstrated. In this study, widespread immune alterations were observed in untreated HCV infection with advanced

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Gröner, Jan Benedikt. "Mitochondriale Dysfunktion bei chronischer Hepatitis B, chronischer Hepatitis C und bei HIV-Postexpositionsprophylaxe." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-135665.

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35

Mohsen, Abdul Hadi. "The epidemiology of hepatitis C and HCV-HIV coinfection." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424448.

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36

Campos, Aléia Faustina. "A influência do vírus da hepatite G (GBV-C) na evolução da infecção pelo HIV em mulheres." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5134/tde-25112010-095806/.

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INTRODUÇÃO: O vírus da hepatite G (GBV-C) foi descoberto simultaneamente por dois grupos de pesquisa que buscavam identificar um agente causador de hepatite pós-transfusional não-A, não-B e não-C. Trata-se de um vírus linfotrópico que replica primariamente em células mononucleares do sangue periférico (PBMC), baço e medula óssea, sendo a replicação hepática menos importante. Sabe-se que, após um período de viremia assintomática, a maioria dos carreadores virais clareia o vírus ao longo do tempo havendo surgimento do anticorpo contra a glicoproteína do envelope viral, anti-E2. Uma vez que, prov

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Maerrawi, Ilham El. "Estudo dos fatores de risco associados às infecções pelo HIV, hepatite B e C e sífilis e suas prevalências em população carcerária de São Paulo." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5137/tde-18012013-120725/.

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INTRODUÇÃO: Infecções pelo HIV, HBV, HCV e Treponema pallidum encontram no sistema prisional um ambiente favorável para suas propagações e representam grave problema de saúde pública. Neste estudo buscamos conhecer o perfil epidemiológico dos reeducandos de uma unidade prisional e a dinâmica do seu comportamento associado às infecções estudadas. Foram medidas as prevalências dessas infecções e suas coinfecções, investigados os potenciais fatores de risco, assim como medido o padrão de uso de drogas no presídio com ênfase no crack. MÉTODOS: Estudo epidemiológico transversal realizado de feverei

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Duberg, Ann-Sofi. "Hepatitis C virus infection a nationwide study of associated morbidity and mortality /." Doctoral thesis, Örebro : Örebro universitet, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-7835.

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Suzuki, Saori. "Basic research for the development of hepatitis C vaccine." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/215372.

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Contents of the present thesis were published in the following articles. 1. Suzuki S, Mori K, Higashino A, Iwasaki Y, Yasutomi Y, Maki N, Akari H. 2016. Persistent replication of a hepatitis C virus genotype 1b-based chimeric clone carrying E1, E2 and p6 regions from GB virus B in a New World monkey. Microbiol Immunol 60:26-34. Copyright © 1999-2016 John Wiley & Sons, Inc.2. Yoshida T, Suzuki S, Iwasaki Y, Kaneko A, Saito A, Enomoto Y, Higashino A, Watanabe A, Suzuki J, Inoue K, Kuroda T, Takada M, Ito R, Ito M, Akari H. 2013. Efficient in vivo depletion of CD8+ T lymphocytes in common marmose

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Okwor, Chisom Ifeoma Adaeze. "Understanding Immune Suppression in Patients with Chronic Hepatitis C Virus Infections." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/41856.

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Hepatitis C Virus (HCV) is a small RNA virus that progresses to chronicity in 50-80% of infected individuals. Direct-acting antivirals (DAAs) are revolutionary treatments for HCV with 90-98% cure rates. However, over time, chronic HCV infections can result in advanced liver disease, including cirrhosis. Patients with advanced fibrosis experience a poor response to vaccination, recurrent infections and increased risk for hepatocellular carcinoma (HCC). These outcomes are, in part, a consequence of immune dysfunction. Increased inhibitory receptor and Galectin-9 (GAL-9) expression is a possible

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Da, Costa Daniel. "Study of cell host factors involved in Hepatitis C virus tropism." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAJ071/document.

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Le virus de l’hépatite C (HCV) est un problème majeur de santé publique. Le développement de nouveaux traitements pour lutter contre le HCV a été ralenti par l’absence de modèles d’études in vitro et in vivo convenables. Le but de mon travail de thèse a été, dans un premier temps, de caractériser les facteurs déterminant le tropisme hépatique du HCV. En exprimant des facteurs clés dans une lignée cellulaire humaine non-hépatocytaire, nous avons reconstitué in fine l’ensemble du cycle viral dans ces cellules. L’entrée du virus dans la cellule hôte fait intervenir différents récepteurs d’entrée

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Almeida, Bruno Silva de. "Relação entre o HLA e o clareamento espontâneo do vírus da hepatite C." Universidade do Estado do Rio de Janeiro, 2010. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1769.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Aproximadamente 20% dos pacientes infectados pelo vírus da hepatite C (HCV) evoluem com clareamento viral espontâneo [3]. Variáveis como etnia e forma de contaminação tornam ainda mais difícil entender os fatores genéticos do hospedeiro que influenciam a evolução da hepatite C. Objetivo: Avaliar a relação entre o perfil de HLA e o clareamento espontâneo da infecção pelo vírus da hepatite C na população brasileira. Métodos: Foi realizada genotipagem dos HLAs -A, -B, -Cw, -DRB1 e -DQB1 em uma amostra de 135 pacientes infectados pelo

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Noble, Caroline Furtado. "Mutações de resistência aos inibidores da polimerase em pacientes monoinfectados pelo vírus da Hepatite C e coinfectados HCV-HIV." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-22082016-162555/.

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Nos últimos anos o tratamento da infecção crônica pelo HCV passou por importantes mudanças. Recentes avanços em biologia molecular proporcionaram o melhor conhecimento sobre a estrutura molecular do HCV e permitiram o desenvolvimento de moléculas que tem como alvo proteínas específicas integrantes do ciclo replicativo do vírus, denominados agentes antivirais de ação direta (DAAs). No Brasil, atualmente, os DAAs aprovados para o tratamento da Hepatite C são: Simeprevir (2ª geração de inibidor de protease), Daclatasvir (inibidor de NS5A) e o Sofosbuvir (inibidor análogo nucleotídeo de polimerase

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Ahmed, Faria. "Role of Macrophage Subsets in CD8+ T Cell Dysfunction in Chronic HCV Infection." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38227.

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Chronic HCV infection causes generalized CD8+T cell impairment, not limited to HCV-specific CD8+ T cells. Infiltrating monocyte-derived macrophages contribute to a micro- environment that could impact CD8+T cells trafficking through the liver. Macrophages can differentiate into pro-inflammatory (M1) and anti-inflammatory (M2a, M2b, and M2c) subsets. Whether macrophage subset generation in chronic HCV infection is altered and if that has a subsequent impact on CD8+T cell functions was not known. I have shown phenotypic alterations in both M1 and M2 macrophages in chronic HCV infection. In parti

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Yuen, King-tai, and 袁敬弟. "A study of pharmacogenomics for therapeutic and prognostic guidance towards hepatitis C virus (HCV) for patients co-infected with HIV." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193555.

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The cost effectiveness of using novel HCV treatment option, telaprevir and boceprevir, should depend on patients’ respond to conventional PEG-INFα and ribavirin therapy. The study of pharmacogenomics, interleukin-28B (IL-28B) polymorphisms, accompanied with the information of HCV genotypes are suggested to have the strongest predictive value of treatment outcomes and prognosis of disease in individuals infected with HCV who are undergoing conventional PEG-INFα and ribavirin therapy. It is extremely valuable in HCV/HIV co-infected patients as these groups of patients require a complex treatment

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Pearce, Emma St Clair. "Development of antibodies and characterisation of the humoral immune responses in a surrogate animal model for hepatitis C virus (HCV)." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/25978.

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Hepatitis C virus (HCV) infection has become a global public health concern with over 130 million people chronically infected and over 350,000 deaths every year from HCV-related liver diseases. GB virus-B (GBV-B) infection in tamarins is a surrogate model for acute HCV infection. Whilst HCV infection commonly leads to chronicity, GBV-B is naturally cleared. To better understand this natural clearance, this project aimed to study the associated humoral immune response to GBV-B. Additionally, GBV-B-specific antibodies were produced with the aim of characterising the pathology of the virus. Previ

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Eddowes, Lucy A. "Interactions of HIV-1 and hepatitis C virus with iron metabolism." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558553.

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Iron is essential for almost all biological systems and its metabolism is perturbed during infection. Clinical evidence suggests that elevated iron status correlates with a poor prognosis in HIV-1 infection. Four steps of the HIV-1 life cycle are thought to be iron dependent: reverse transcription, transcription, nuclear export of mRNA and virion assembly. The HIV protein Nef downregulates the haemochromatosis protein HFE in vitro, and iron chelators can inhibit HIV-1 replication. Given the evidence that iron can affect HIV -1 disease course and replication we investigated HIV -1 replication i

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Schlottmann, Renate. "Zirkulierendes Interleukin-18 im Verlauf der HIV-Infektion und HIV-Hepatitis B- und C-Koinfektion." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=97450727X.

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Boyd, Anders. "Clinical epidemiology of multi-viral hepatitis infection among HIV-HBV infected patients." Paris 6, 2010. http://www.theses.fr/2010PA066618.

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Ces dix dernières années, l'allongement de l'espérance de vie des patients infectés par le VIH s'est accompagné de l'apparition de co-morbidités, en particulier hépatiques, dues aux co-infections chroniques par les virus des hépatites B (VHB), C (VHC) et Delta (VHD). Alors que les patients co-infectés par le VIH-VHB sont plus à risque d'être infectés par d'autres virus des hépatites chroniques, les données concernant spécifiquement l'influence respective des co-infections VHC, VHD et VHC-VHD sur les conséquences cliniques, le suivi virologique et l'efficacité du traitement dans le contexte du

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Pelletier, Pascale. "Porphyrie cutanée tardive et infection par les virus des hépatites B, C, G, et le virus VIH. Etude de 53 cas en Languedoc-Roussillon." Montpellier 1, 1999. http://www.theses.fr/1999MON11138.

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