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Journal articles on the topic 'HLA histocompatibility antigens'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 July 2024

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1

Barbosa, J., H. Noreen, L. Emme, F. Goetz, R. Simmons, A. DeLeiva, J. Najarian, and E. J. Yunis. "Histocompatibility (HLA) Antigens and Diabetic Microangiopathy*." Tissue Antigens 7, no. 4 (December 11, 2008): 233–37. http://dx.doi.org/10.1111/j.1399-0039.1976.tb01060.x.

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Veerapathran, Anandharaman, Joseph Pidala, Francisca Beato, William E. Janssen, Xue-Zhong Yu, and Claudio Anasetti. "Tregs Specific for Minor Histocompatibility Antigens." Blood 120, no. 21 (November 16, 2012): 1891. http://dx.doi.org/10.1182/blood.v120.21.1891.1891.

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Abstract Abstract 1891 Background: The risk of acute GVHD after HSCT is increased in male recipients of female grafts. Disparities for the male-associated H-Y and other minor histocompatibility antigens (mHAs) have the capacity to sensitize alloreactive donor T cells and cause GVHD in HLA-matched recipients. These mHAs are polymorphic proteins that differ between donor and recipient and are presented as peptides by HLA molecules on recipient or donor antigen-presenting cells to donor immune cells. Currently, there is no evidence that minor histocompatibility antigen specific Tregs exist. Earli

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3

Mu�oz, G., M. P. L�pez-Corell, J. F. Taboada, E. Ferrer, and M. D�az-Llopis. "Fuch's heterochromic cyclitis and HLA histocompatibility antigens." International Ophthalmology 18, no. 3 (1994): 127–30. http://dx.doi.org/10.1007/bf00915960.

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4

Razumova, I. Yu, A. A. Godzenko, I. A. Guseva, and O. K. Vorob’eva. "Uveitis-associated HLA class 1 histocompatibility antigens." Vestnik oftal'mologii 133, no. 5 (2017): 11. http://dx.doi.org/10.17116/oftalma2017133511-15.

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5

DAMGAARD-JENSEN, L., and F. KISSMEYER-NIELSEN. "HLA HISTOCOMPATIBILITY ANTIGENS IN OPEN-ANGLE GLAUCOMA." Acta Ophthalmologica 56, no. 3 (May 27, 2009): 384–88. http://dx.doi.org/10.1111/j.1755-3768.1978.tb05691.x.

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6

Falkenburg, J. H., H. M. Goselink, D. van der Harst, S. A. van Luxemburg-Heijs, Y. M. Kooy-Winkelaar, L. M. Faber, J. de Kroon, A. Brand, W. E. Fibbe, and R. Willemze. "Growth inhibition of clonogenic leukemic precursor cells by minor histocompatibility antigen-specific cytotoxic T lymphocytes." Journal of Experimental Medicine 174, no. 1 (July 1, 1991): 27–33. http://dx.doi.org/10.1084/jem.174.1.27.

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Minor histocompatibility (mH) antigens appear to play a major role in bone marrow transplantation (BMT) using HLA-identical donors. Previously, we reported the isolation of major histocompatibility complex (MHC)-restricted mH antigen-specific cytotoxic T lymphocytes (CTL) from patients with graft-vs.-host disease or rejection after HLA-identical BMT. We have demonstrated that mH antigens can be recognized on hematopoietic progenitor cells, and residual recipient CTL specific for mH antigens expressed on donor hematopoietic progenitor cells may be responsible for graft rejection in spite of int

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7

IBRAGIMOV, SH I., G. T. MANSUROVA, U. A. MAMATKULOV, and M. R. MAKHSUDOV. "Studying of relationship of Histocompatibility antigens and N-acetylation phenotype in patients of Uzbek populations with psoriasis." Vestnik dermatologii i venerologii 86, no. 1 (February 15, 2010): 67–69. http://dx.doi.org/10.25208/vdv834.

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There studied the distribution of Histocompatibility antigens and N-acetylation phenotype in patients of Uzbek populations with psoriasis and it has been revealed, that HLA antigenes A11, A28, В5, В13 and Cw3 are antigenes of predisposition to presented disease and the individuals with slow N-acetylation phenotype prevail among them. The relationship of more frequent associated Histocompatibility antigens and N-acetylation phenotype marked by the prevalence of patients with a slow phenotype in the dermatosis has been revealed in patients of Uzbek populations with psoriasis.

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Ramilyeva, I. R., Zh K. Burkitbaev, S. A. Abdrakhmanova, A. A. Turganbekova, D. K. Baimukasheva, and E. B. Zhiburt. "DISTRIBUTION PATTERN FOR HLA SPECIFICITIES IN THE PATIENTS WITH ACUTE MYELOID LEUKEMIA." Medical Immunology (Russia) 21, no. 5 (December 13, 2019): 965–72. http://dx.doi.org/10.15789/1563-0625-2019-5-965-972.

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The article presents a study on the distribution of gene polymorphisms in the histocompatibility antigens among the patients diagnosed with AML, and healthy donors in the Republic of Kazakhstan, as well as features of the HLA-A*, *B, Cw*, DRB1*, DQB1* distribution among the patients with acute myeloid leukemia (AML). HLA typing and data processing were performed at the Research and Production Center of Transfusiology, Nur-Sultan. A total of 3808 people were examined, including 3621 healthy blood donors and 187 patients diagnosed with AML. Genomic DNA for HLA typing was isolated from peripheral

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9

Romanyuk, D. S., A. M. Pilunov, G. A. Efimov, A. V. Bogolyubova, and E. N. Parovichnikova. "Minor histocompatibility antigens represented in HLA-A*02:01 and their search strategies." Oncohematology 18, no. 3 (September 13, 2023): 115–24. http://dx.doi.org/10.17650/1818-8346-2023-18-3-115-124.

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Minor histocompatibility antigens (MiHAs) are polymorphic peptides on the cell surface derived from self-proteins that are capable to induce an immune response during allogeneic hematopoietic stem cells transplantation. Their presentation occurs in the context of the certain major histocompatibility complex (HLA – human leucocyte antigen) alleles. One of the most common HLA alleles is HLA-A*02:01. Accordingly, for a significant number of donors and recipients pairs, it is possible to use the MiHAs presented in the HLA-A*02:01 as a target for relapsed leukemia therapy. This review discusses the

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10

Stern, Martin, Loredana Ruggeri, Marusca Capanni, Antonella Mancusi, and Andrea Velardi. "Human leukocyte antigens A23, A24, and A32 but not A25 are ligands for KIR3DL1." Blood 112, no. 3 (August 1, 2008): 708–10. http://dx.doi.org/10.1182/blood-2008-02-137521.

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Abstract Inhibitory killer cell immunoglobulin receptors (KIR) bind to major histocompatibility complex antigens. Concise knowledge of KIR ligands allows prediction of natural killer (NK)–cell alloreactivity after hematopoietic stem cell transplantation. KIR3DL1 binds to the Bw4 epitope on HLA-B antigens. Although the same epitope is also found on 4 HLA-A antigens (HLA-A23/24/25/32), these are not currently regarded as KIR3DL1 ligands. We show that expression of HLA A*2301, A*2402, or A*3201 but not HLA A*2501 protects target cells from lysis by KIR3DL1+ NK cells. KIR3DL1+ NK cells from donors

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Kolyubaeva, Svetlana N., Liliya A. Myakoshina, Marina I. Eliseeva, and Ruslan I. Glushakov. "HLA typing methods used for organ and tissue transplantation." Russian Military Medical Academy Reports 40, no. 2 (July 14, 2021): 21–32. http://dx.doi.org/10.17816/rmmar81197.

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The antigen system on the surface of human cells is responsible for recognizing foreign antigens. In organ transplantation, the immune system reacts to all foreign antigens that are different from the recipients antigens. In practice, solid organ transplantation is carried out with varying degrees of genetic discrepancy, while the main principle that should be followed to prevent acute and chronic transplant rejection reactions is to avoid unacceptable discrepancies. As a result, the diagnosis of typing genes of histocompatibility allows you to select a donor to which the recipient will not ha

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Vogt, M. H. J., R. A. de Paus, P. J. Voogt, R. Willemze, and J. H. F. Falkenburg. "DFFRY codes for a new human male-specific minor transplantation antigen involved in bone marrow graft rejection." Blood 95, no. 3 (February 1, 2000): 1100–1105. http://dx.doi.org/10.1182/blood.v95.3.1100.003k42_1100_1105.

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Graft rejection after histocompatibility locus antigen (HLA)-identical stem cell transplantation results from the recognition of minor histocompatibility antigens on donor stem cells by immunocompetent T lymphocytes of recipient origin. T-lymphocyte clones that specifically recognize H-Y epitopes on male target cells have been generated during graft rejection after sex-mismatched transplantation. Previously, 2 human H-Y epitopes derived from the same SMCY gene have been identified that were involved in bone marrow graft rejection. We report the identification of a new male-specific transplanta

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Kao, KJ, DJ Cook, and JC Scornik. "Quantitative analysis of platelet surface HLA by W6/32 anti-HLA monoclonal antibody." Blood 68, no. 3 (September 1, 1986): 627–32. http://dx.doi.org/10.1182/blood.v68.3.627.627.

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Abstract Class I molecules of human major histocompatibility complex (HLA) are the most important antigenic system in determining the survival of transfused platelets in alloimmunized patients. Platelets with reduced expression of a specific type of HLA antigen may escape specific anti- HLA antibody-mediated destruction. By using 125I-labeled Fab fragments of W6/32 anti-HLA monoclonal antibody and competitive protein binding assays, we measured the range of total HLA concentrations on platelets. In 12 individuals examined, the mean number of HLA-A, B, and C molecules per platelet was 81,587 +/

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Kao, KJ, DJ Cook, and JC Scornik. "Quantitative analysis of platelet surface HLA by W6/32 anti-HLA monoclonal antibody." Blood 68, no. 3 (September 1, 1986): 627–32. http://dx.doi.org/10.1182/blood.v68.3.627.bloodjournal683627.

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Class I molecules of human major histocompatibility complex (HLA) are the most important antigenic system in determining the survival of transfused platelets in alloimmunized patients. Platelets with reduced expression of a specific type of HLA antigen may escape specific anti- HLA antibody-mediated destruction. By using 125I-labeled Fab fragments of W6/32 anti-HLA monoclonal antibody and competitive protein binding assays, we measured the range of total HLA concentrations on platelets. In 12 individuals examined, the mean number of HLA-A, B, and C molecules per platelet was 81,587 +/- 20,016

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15

Ismagilov, S. M. "Distribution of histocompatibility antigens among patients with otosclerosis." Kazan medical journal 76, no. 1 (January 15, 1995): 19–22. http://dx.doi.org/10.17816/kazmj80089.

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HLA-A-B-C phenotypes in 105 patients with otosclerosis, verificated during operation and correlated with the results of histoiden- tification of 113 healthy persons are determined. It is suggested that the ethnic sign does not influence the formation of the peculiarities of HLA polymorphism. The patients were devided into two groups: with familial predisposition to otosclerosis (33) and without it (72). A2, В12, Bx, Cx antigens are more frequent among them and A28, В18, B27, B40 and Cwl are less common. The associations, intending among the patients, are absent in patients with familial agrgat

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16

Jäger, Elke, Yao-Tseng Chen, Jan W. Drijfhout, Julia Karbach, Mark Ringhoffer, Dirk Jäger, Michael Arand, et al. "Simultaneous Humoral and Cellular Immune Response against Cancer–Testis Antigen NY-ESO-1: Definition of Human Histocompatibility Leukocyte Antigen (HLA)-A2–binding Peptide Epitopes." Journal of Experimental Medicine 187, no. 2 (January 19, 1998): 265–70. http://dx.doi.org/10.1084/jem.187.2.265.

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A growing number of human tumor antigens have been described that can be recognized by cytotoxic T lymphocytes (CTLs) in a major histocompatibility complex (MHC) class I–restricted fashion. Serological screening of cDNA expression libraries, SEREX, has recently been shown to provide another route for defining immunogenic human tumor antigens. The detection of antibody responses against known CTL-defined tumor antigens, e.g., MAGE-1 and tyrosinase, raised the question whether antibody and CTL responses against a defined tumor antigen can occur simultaneously in a single patient. In this paper,

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17

GÖNEN, Sevim, Sinan SARI, Yaşar KANDUR, Buket DALGIÇ, and Oğuz SÖYLEMEZOĞLU. "EVALUATION OF HUMAN LEUKOCYTE ANTIGEN CLASS I AND II ANTIGENS IN HELICOBACTER PYLORI-POSITIVE PEDIATRIC PATIENTS WITH ACTIVE GASTRITIS AND DUODENAL ULCER." Arquivos de Gastroenterologia 54, no. 4 (October 2, 2017): 297–99. http://dx.doi.org/10.1590/s0004-2803.201700000-62.

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ABSTRACT BACKGROUND: As being the first bacteria determined to be carcinogenic, Helicobacter pylori (H. pylori) is a pathogen localized in the stomach in more than half of the world population. Some earlier studies have found a relation between tissue histocompatibility antigens and gastric cancers depending on the regions. OBJECTIVE: The present study aimed to determine the distribution of human leukocyte antigen (HLA) class I and class II antigens in H. pylori-positive pediatric patients with active gastritis and duodenal ulcer, excluding cancer cases, in our center. METHODS: The study inclu

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18

Chersi, Alberto, Richard A. Houghten, Maria C. Morganti, and Eleonora Muratti. "Recognition of HLA Class II Molecules by Antipeptide Antibodies Elicited by Synthetic Peptides Selected from Regions of HLA-DP Antigens." Zeitschrift für Naturforschung C 42, no. 11-12 (December 1, 1987): 1313–18. http://dx.doi.org/10.1515/znc-1987-11-1227.

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Repeated immunizations of rabbits with chemically synthesized peptides from selected regions of HLA-DP histocompatibility antigens resulted in the production of specific antibodies that were then isolated from the immune sera by chromatography on Sepharose-peptide immunoadsorbents. The purified antibodies, when tested with an enzyme-linked immunosorbant assay, specifically bound to the inciting fragments; moreover, two of them recognized glycoproteins extracted by nonionic detergents from human chronic lymphocytic leukemia cells, as revealed by binding assays. The results suggest that amino ac

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19

Berard, Frederic, Patrick Blanco, Jean Davoust, Eve-Marie Neidhart-Berard, Mahyar Nouri-Shirazi, Nicolas Taquet, Donata Rimoldi, Jean Charles Cerottini, Jacques Banchereau, and A. Karolina Palucka. "Cross-Priming of Naive Cd8 T Cells against Melanoma Antigens Using Dendritic Cells Loaded with Killed Allogeneic Melanoma Cells." Journal of Experimental Medicine 192, no. 11 (November 27, 2000): 1535–44. http://dx.doi.org/10.1084/jem.192.11.1535.

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The goal of tumor immunotherapy is to elicit immune responses against autologous tumors. It would be highly desirable that such responses include multiple T cell clones against multiple tumor antigens. This could be obtained using the antigen presenting capacity of dendritic cells (DCs) and cross-priming. That is, one could load the DC with tumor lines of any human histocompatibility leukocyte antigen (HLA) type to elicit T cell responses against the autologous tumor. In this study, we show that human DCs derived from monocytes and loaded with killed melanoma cells prime naive CD45RA+CD27+CD8+

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20

Versteeg, R., K. M. Krüse-Wolters, A. C. Plomp, A. van Leeuwen, N. J. Stam, H. L. Ploegh, D. J. Ruiter, and P. I. Schrier. "Suppression of class I human histocompatibility leukocyte antigen by c-myc is locus specific." Journal of Experimental Medicine 170, no. 3 (September 1, 1989): 621–35. http://dx.doi.org/10.1084/jem.170.3.621.

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The c-myc oncogene downregulates class I HLA expression in human melanoma. The major class I HLA antigens are encoded by three loci, A, B, and C, and we investigated whether these loci are suppressed equally by c-myc. In three melanoma cell lines with high c-myc expression, we analyzed mRNA, protein, and cell surface expression of the class I HLA antigens. Whereas the HLA-B locus expression was found to be strongly reduced, the HLA-A locus was expressed normally. Analysis of c-myc-transfected clones of two melanoma cell lines confirmed that c-myc preferentially suppresses the class I HLA-B loc

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21

Anderson, D. J., and R. S. Berkowitz. "Gamma-interferon enhances expression of Class I MHC antigens in the weakly HLA+ human choriocarcinoma cell line BeWo, but does not induce MHC expression in the HLA- choriocarcinoma cell line Jar." Journal of Immunology 135, no. 4 (October 1, 1985): 2498–501. http://dx.doi.org/10.4049/jimmunol.135.4.2498.

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Abstract PHA-activated lymphocyte supernatants and high doses of affinity-purified human gamma-interferon enhance the expression of apparently normal Class I histocompatibility antigens in a malignant human trophoblast cell line that expresses low amounts of these antigens under normal culture conditions. Another human choriocarcinoma cell line, Jar, which is normally HLA-, did not respond to this treatment. This system provides a model in which to study further the regulation and effects of MHC antigen expression in cells of trophoblastic origin.

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van der Harst, D., E. Goulmy, JH Falkenburg, YM Kooij-Winkelaar, SA van Luxemburg- Heijs, HM Goselink, and A. Brand. "Recognition of minor histocompatibility antigens on lymphocytic and myeloid leukemic cells by cytotoxic T-cell clones." Blood 83, no. 4 (February 15, 1994): 1060–66. http://dx.doi.org/10.1182/blood.v83.4.1060.1060.

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Abstract Clinical studies indicated an enhanced antileukemic effect of allogeneic bone marrow transplantation (BMT), as compared with autologous BMT. After allogeneic HLA-identical BMT, donor-derived cytotoxic T lymphocytes (CTLs) directed at minor histocompatibility (mH) antigens on the recipients, tissues can be shown. To evaluate the antileukemic reactivity of mH antigen-specific CTLs, we analyzed the expression of mH antigens on circulating lymphocytic and myeloid leukemic cells. We show that the defined mH specificities HA-1 through HA-5 and H-Y are present on leukemic cells, indicating t

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van der Harst, D., E. Goulmy, JH Falkenburg, YM Kooij-Winkelaar, SA van Luxemburg- Heijs, HM Goselink, and A. Brand. "Recognition of minor histocompatibility antigens on lymphocytic and myeloid leukemic cells by cytotoxic T-cell clones." Blood 83, no. 4 (February 15, 1994): 1060–66. http://dx.doi.org/10.1182/blood.v83.4.1060.bloodjournal8341060.

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Clinical studies indicated an enhanced antileukemic effect of allogeneic bone marrow transplantation (BMT), as compared with autologous BMT. After allogeneic HLA-identical BMT, donor-derived cytotoxic T lymphocytes (CTLs) directed at minor histocompatibility (mH) antigens on the recipients, tissues can be shown. To evaluate the antileukemic reactivity of mH antigen-specific CTLs, we analyzed the expression of mH antigens on circulating lymphocytic and myeloid leukemic cells. We show that the defined mH specificities HA-1 through HA-5 and H-Y are present on leukemic cells, indicating that mH an

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Yagüe, Jesús, Iñaki Alvarez, Didier Rognan, Manuel Ramos, Jesús Vázquez, and José A. López de Castro. "An N-Acetylated Natural Ligand of Human Histocompatibility Leukocyte Antigen (Hla)-B39." Journal of Experimental Medicine 191, no. 12 (June 12, 2000): 2083–92. http://dx.doi.org/10.1084/jem.191.12.2083.

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Sequence-independent interactions involving the free peptidic NH2 terminus are thought to be an essential feature of peptide binding to classical major histocompatibility complex (MHC) class I proteins. Challenging this paradigm, a natural Nα-acetylated ligand of human histocompatibility leukocyte antigen (HLA)-B39 was identified in this study. It matched the NH2-terminal sequence of two human helicases, was resistant to aminopeptidase M, and was produced with high yield from a synthetic 30 mer with the sequence of the putative parental protein by the 20S proteasome. This is the first reported

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TSUJIMURA, AKIRA, SHIRO TAKAHARA, MASAYA KTTAMURA, HIDENOBU NQURA, MINORU KOGA, MASAHARU SADA, TAKAYUKI TSUJI, KIYOMI MATSUMIYA, and AKIHIKO OKUYAMA. "HLA‐DR Antigen and HLA‐DRB1 Genotyping with Nonobstructive Azoospermia in Japan." Journal of Andrology 20, no. 4 (July 8, 1999): 545–50. http://dx.doi.org/10.1002/j.1939-4640.1999.tb02554.x.

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ABSTRACT: We previously reported that the HLA‐A33, ‐B13, and ‐B44 antigens, which are major histocompatibility complex class I molecules, are involved in the susceptibility of nonobstructive azoospermia in Japanese men. In this report, HLA‐DR antigens, which are class II molecules, are investigated by advanced DNA typing in addition to classical serological typing to study a more complex genotype of HLA‐DRB2. Genotyping was performed by the polymerase chain reaction‐sequence‐specific primer (PCR‐SSP) method of analysis and/or by a commercial rapid assay based on the polymerase chain reaction (

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Dohr, G. A., W. Motter, S. Leitinger, G. Desoye, W. Urdl, R. Winter, M. M. Wilders-Truschnig, B. Uchanska-Ziegler, and A. Ziegler. "Lack of expression of HLA [corrected] class I and class II molecules on the human oocyte." Journal of Immunology 138, no. 11 (June 1, 1987): 3766–70. http://dx.doi.org/10.4049/jimmunol.138.11.3766.

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Abstract The expression of histocompatibility leukocyte antigen (HLA) class I and class II antigens on human oocytes was investigated by the indirect immunofluorescence assay using well-defined monoclonal antibodies. Oocytes were obtained from an in vitro fertilization program or were studied on frozen sections from human ovaries. Neither HLA class I, beta 2-microglobulin, nor HLA class II molecules were detected on cultured oocytes or frozen sections. The zona pellucida also lacked these antigens, but granulosa cells expressed HLA class I molecules. Our results also indicate the presence of c

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Olsen, Kelly Shea, Hancong Tang, Junke Wang, Sarah Entwistle, Dante S. Bortone, Steven Vensko, Loreall Pooler, et al. "Population Distribution of GvL and GvH Minor Histocompatibility Antigens." Blood 136, Supplement 1 (November 5, 2020): 23–25. http://dx.doi.org/10.1182/blood-2020-141120.

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Background: Donor-derived T cells that target minor histocompatibility antigens (mHAs) in allogeneic hematopoietic cell transplant (HCT) mediate graft versus leukemia (GvL) and graft versus host (GvH) effects. Prediction of mHAs that drive GvL has garnered interest for targeted immunotherapy, but there have been few large-scale studies of population prevalence of predicted mHAs. Prioritization of mHAs that are shared among patients would allow for treatment of more individuals with mHA-targeting therapies. We report here population metrics of predicted mHAs in a dataset of over 3000 patients t

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OLIVIUS, ESKIL, and WERNER POLLAND. "HISTOCOMPATIBILITY (HLA) ANTIGENS IN CAPSULAR GLAUCOMA AND SIMPLEX GLAUCOMA." Acta Ophthalmologica 58, no. 3 (May 27, 2009): 406–10. http://dx.doi.org/10.1111/j.1755-3768.1980.tb05740.x.

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Chaux, Pascal, Valérie Vantomme, Vincent Stroobant, Kris Thielemans, Jurgen Corthals, Rosalie Luiten, Alexander M. M. Eggermont, Thierry Boon, and Pierre van der Bruggen. "Identification of MAGE-3 Epitopes Presented by HLA-DR Molecules to CD4+ T Lymphocytes." Journal of Experimental Medicine 189, no. 5 (March 1, 1999): 767–78. http://dx.doi.org/10.1084/jem.189.5.767.

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MAGE-type genes are expressed by many tumors of different histological types and not by normal cells, except for male germline cells, which do not express major histocompatibility complex (MHC) molecules. Therefore, the antigens encoded by MAGE-type genes are strictly tumor specific and common to many tumors. We describe here the identification of the first MAGE-encoded epitopes presented by histocompatibility leukocyte antigen (HLA) class II molecules to CD4+ T lymphocytes. Monocyte-derived dendritic cells were loaded with a MAGE-3 recombinant protein and used to stimulate autologous CD4+ T c

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Sultana, Sharmin, Shahina Tabassum, and Afzalun Nessa. "Human Leukocyte Antigen: Class I Allele Frequencies and Haplotype Distributionin a Tertiary Care Hospital in Bangladesh." Bangladesh Medical Research Council Bulletin 44, no. 1 (June 6, 2018): 1–8. http://dx.doi.org/10.3329/bmrcb.v44i1.36798.

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Human leukocyte antigen (HLA) are cell surface glycoproteins encoded by Major Histocompatibility Complex (MHC) geneof human genome. HLA antigen frequency and haplotype distribution are useful for determining disease associations, origin, migration and genetic relationships between populations and predicting the outcome of transplantation. Thus, the present study was carried outto identify HLA class I (HLA-A and HLA-B) antigen and haplotype distribution among a selected Bangladeshi population. This retrospective study was conducted among 1070 individuals who were referred by cliniciansfor HLA t

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Severinsson, L., I. Martens, and P. A. Peterson. "Differential association between two human MHC class I antigens and an adenoviral glycoprotein." Journal of Immunology 137, no. 3 (August 1, 1986): 1003–9. http://dx.doi.org/10.4049/jimmunol.137.3.1003.

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Abstract The glycoprotein E19, encoded in early region 3 of adenovirus-2, forms complexes with major histocompatibility complex class I antigens. As a result of the complex formation, the intracellular transport of the class I antigens is abrogated, and adenovirus-infected cells display gradually diminishing quantities of cell surface-expressed class I molecules. To assess whether the E19 protein interacts equally well with different class I antigens, the associations between the viral protein and HLA-A2 and HLA-B7 antigens have been estimated. By infecting transfected HeLa cells expressing va

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Tilkin, A. F., M. Bagot, M. Kayibanda, J. P. Vernant, and J. P. Levy. "A human autoreactive T cell line specific for minor histocompatibility antigen(s) isolated from a bone marrow-grafted patient." Journal of Immunology 137, no. 12 (December 15, 1986): 3772–76. http://dx.doi.org/10.4049/jimmunol.137.12.3772.

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Abstract A human autoreactive T cell line named Bur-1 has been obtained from a woman 4 mo after an allogeneic bone marrow transplantation (BMT) from one of her HLA-identical brothers. The phenotype of the cell line is 100% T11+ and over 90% T4+, and the karyotype confirms its donor (male) origin. These donor T cells proliferate specifically in the presence of donor's peripheral blood monocytes (PBM) but not recipient's cells, and they kill specifically donor's but not recipient's Epstein-Barr virus (EBV)-induced lymphoblastoid cell lines (LCL). PBM from another HLA-identical brother and from s

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Inman, R. D. "Immunogenetic aspects of host immune response." Canadian Journal of Microbiology 34, no. 3 (March 1, 1988): 319–22. http://dx.doi.org/10.1139/m88-058.

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The central role of histocompatibility leukocyte antigens (HLA) class II molecules in antigen presentation has received great attention in recent years, yet class I molecules have been defined as primarily functioning as a restriction element for cytotoxic T cell killing of virus-infected cells. Extensive clinical evidence, however, indicates that the HLA class I genes are strongly associated with nonseptic complications of enteric and genitourinary bacterial infections. Ninety percent of patients with Reiter's syndrome and reactive arthritis are positive for HLA-B27, yet the mechanism of dise

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Verdijk, Rob M., Antoinette Kloosterman, Jos Pool, Maarten van de Keur, Albert M. I. H. Naipal, Astrid G. S. van Halteren, Anneke Brand, Tuna Mutis, and Els Goulmy. "Pregnancy induces minor histocompatibility antigen–specific cytotoxic T cells: implications for stem cell transplantation and immunotherapy." Blood 103, no. 5 (March 1, 2004): 1961–64. http://dx.doi.org/10.1182/blood-2003-05-1625.

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AbstractRecipients of HLA-identical stem cell transplants have a poorer transplant outcome if the donor is female rather than male. We analyzed whether pregnancy primes for minor histocompatibility (H) antigens. Peripheral blood mononuclear cells (PBMCs) from healthy multiparous female blood donors were depleted for CD4+, CD14+, CD16+, and CD19+ cells, stained with minor H antigen–specific HLA-A2 tetramers, sorted by fluorescence-activated cell sorting, and tested for cytotoxic activity. Minor H antigens HY-, HA-1–, and HA-2–specific cytotoxic T cells (CD8+, CD45RA–) were present in PBMCs from

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Ayala García, Marco Antonio, Beatriz González Yebra, Andrea Liliana López Flores, and Eduardo Guaní Guerra. "The Major Histocompatibility Complex in Transplantation." Journal of Transplantation 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/842141.

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The transplant of organs is one of the greatest therapeutic achievements of the twentieth century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the principal target of the immune response is the MHC (major histocompatibility complex) molecules expressed on the surface of donor cells. However, we should not forget that the innate and adaptive immunities are closely interrelated and should be viewed as complementary and cooperating. When a human transplant is performed, HLA (human leukocyte antigens) molecules from a do

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Heemskerk, Mirjam H. M., Manja Hoogeboom, Renate Hagedoorn, Michel G. D. Kester, Roel Willemze, and J. H. Frederik Falkenburg. "Reprogramming of Virus-specific T Cells into Leukemia-reactive T Cells Using T Cell Receptor Gene Transfer." Journal of Experimental Medicine 199, no. 7 (March 29, 2004): 885–94. http://dx.doi.org/10.1084/jem.20031110.

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T cells directed against minor histocompatibility antigens (mHags) might be responsible for eradication of hematological malignancies after allogeneic stem cell transplantation. We investigated whether transfer of T cell receptors (TCRs) directed against mHags, exclusively expressed on hematopoietic cells, could redirect virus-specific T cells toward antileukemic reactivity, without the loss of their original specificity. Generation of T cells with dual specificity may lead to survival of these TCR-transferred T cells for prolonged periods of time in vivo due to transactivation of the endogeno

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Manandhar, Rekha, Gaurab Pandey, Ranjan Raj Bhatta, and Runa Jha. "Analysis of Human Leukocyte Antigen Frequency among Renal Transplant Recipients and Donors in Nepal." Global Journal of Transfusion Medicine 9, no. 1 (January 2024): 57–60. http://dx.doi.org/10.4103/gjtm.gjtm_79_23.

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ABSTRACT Background and Objectives: Kidney transplants are effective for advanced renal failure, but graft rejection can occur when the recipient’s immune system misidentifies the kidney as a foreign object. Human leukocyte antigen (HLA), a component of the host’s immunological defense system, acts as a barrier to graft rejection. Selecting potential kidney recipients and donors for transplantation requires careful consideration of histocompatibility for the HLA-A, HLA-B, and HLA-DRB1 antigens. Mismatches between donors and recipients prolong transplant therapy, leading to lower graft survival

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Kraemer, Thomas, Rainer Blasczyk, and Christina Bade-Doeding. "HLA-E: A Novel Player for Histocompatibility." Journal of Immunology Research 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/352160.

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The classical class I human leukocyte antigens (HLA-A, -B, and -C) present allele-specific self- or pathogenic peptides originated by intracellular processing to CD8+immune effector cells. Even a single mismatch in the heavy chain (hc) of an HLA class I molecule can impact on the peptide binding profile. Since HLA class I molecules are highly polymorphic and most of their polymorphisms affect the peptide binding region (PBR), it becomes obvious that systematic HLA matching is crucial in determining the outcome of transplantation. The opposite holds true for the nonclassical HLA class I molecul

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Yamamoto, J., A. Kariyone, N. Akiyama, K. Kano, and M. Takiguchi. "Presentation of human minor histocompatibility antigens by HLA-B35 and HLA-B38 molecules." Proceedings of the National Academy of Sciences 87, no. 7 (April 1, 1990): 2583–87. http://dx.doi.org/10.1073/pnas.87.7.2583.

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van Ham, Marieke, Marcel van Lith, Björn Lillemeier, Esther Tjin, Ulrike Grüneberg, Dinah Rahman, Liesbeth Pastoors, et al. "Modulation of the Major Histocompatibility Complex Class II–Associated Peptide Repertoire by Human Histocompatibility Leukocyte Antigen (Hla)-Do." Journal of Experimental Medicine 191, no. 7 (March 27, 2000): 1127–36. http://dx.doi.org/10.1084/jem.191.7.1127.

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Antigen presentation by major histocompatibility complex class II molecules is essential for antibody production and T cell activation. For most class II alleles, peptide binding depends on the catalytic action of human histocompatibility leukocyte antigens (HLA)-DM. HLA-DO is selectively expressed in B cells and impedes the activity of DM, yet its physiological role remains unclear. Cell surface iodination assays and mass spectrometry of major histocompatibility complex class II–eluted peptides show that DO affects the antigenic peptide repertoire of class II. DO generates both quantitative a

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Zaborek-Łyczba, Monika, Jakub Łyczba, Paulina Mertowska, Sebastian Mertowski, Anna Hymos, Martyna Podgajna, Paulina Niedźwiedzka-Rystwej, and Ewelina Grywalska. "The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases." International Journal of Molecular Sciences 22, no. 24 (December 12, 2021): 13348. http://dx.doi.org/10.3390/ijms222413348.

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The human G-leukocyte antigen (HLA-G) molecule is a non-classical major histocompatibility complex (MHC) class I molecule. The pertinence of HLA-G has been investigated in numerous studies which have sought to elucidate the relevance of HLA-G in pathologic conditions, such as autoimmune diseases, cancers, and hematologic malignancies. One of the main goals of the current research on HLA-G is to use this molecule in clinical practice, either in diagnostics or as a therapeutic target. Since HLA-G antigens are currently considered as immunomodulatory molecules that are involved in reducing inflam

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Kim, Ae, Isamu Hartman, and Scheherazade Sadegh-Nasseri. "Survival of antigenic epitope requires class II MHC capture prior to lysosomal proteolysis (93.21)." Journal of Immunology 178, no. 1_Supplement (April 1, 2007): S170. http://dx.doi.org/10.4049/jimmunol.178.supp.93.21.

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Abstract The paradigmatic model for the generation of peptide determinants for class II major histocompatibility complex molecules (MHC II) is that proteolytic fragmentation of antigen precedes the capture of the resulting peptides by MHC II (cut/trim first, bind later). However, circumstantial evidence exists to support an alternate model in which MHC II binding of antigenic epitope occurs prior to the proteolytic fragmentation of that antigen (bind first, cut/trim later). To distinguish between these two models, we analyzed the interaction of HLA-DR1 with two protein antigens, type II collag

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Doyle, A., W. J. Martin, K. Funa, A. Gazdar, D. Carney, S. E. Martin, I. Linnoila, F. Cuttitta, J. Mulshine, and P. Bunn. "Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancer." Journal of Experimental Medicine 161, no. 5 (May 1, 1985): 1135–51. http://dx.doi.org/10.1084/jem.161.5.1135.

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We have found markedly deficient expression of the class I major histocompatibility antigens HLA-A,B,C and beta 2m on human small-cell lung cancer (SCLC) lines and fresh tumor samples. The deficit of HLA-A,B,C and beta 2-microglobulin (beta 2m) antigen expression was demonstrated with both radiobinding assays and indirect immunofluorescence assays. Immunoprecipitation of metabolically labeled cells with antibodies to class I antigens showed most SCLC lines to have synthesized almost no beta 2m and HLA-A,B,C proteins. Northern blot analysis, using human HLA-A,B, and beta 2m cDNA probes, showed

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Ogasawara, M., D. H. Kono, and D. T. Yu. "Mimicry of human histocompatibility HLA-B27 antigens by Klebsiella pneumoniae." Infection and Immunity 51, no. 3 (1986): 901–8. http://dx.doi.org/10.1128/iai.51.3.901-908.1986.

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Driianska, V., O. Petrina, M. Velychko, F. Haisenyuk, and G. Drannik. "Peculiarities of phenotypes of patients with pyelo- and glomerulonephritis by HLA distribution analysis." Ukrainian Journal of Nephrology and Dialysis, no. 4(60) (December 26, 2018): 11–18. http://dx.doi.org/10.31450/ukrjnd.4(60).2018.02.

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Studies devoted to the role of human leucocyte antigens (HLA) in pathogenesis of chronic kidney disease (CKD) have demonstrated the associative links of the HLA antigens, which stipulate the relative and attributive risks of some autoimmune diseases, with immune disorder and a high production of pro-inflammatory cytokines. The aim of our study was to determine the peculiarities of phenotypes of CKD patients according to the distribution of HLA-A, B and DR antigens and to conduct their comparative analysis in patients with pyelonephritis (PN) and glomerulonephritis (GN). Methods: Th

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Archbold, Julia K., Whitney A. Macdonald, Stephanie Gras, Lauren K. Ely, John J. Miles, Melissa J. Bell, Rebekah M. Brennan, et al. "Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition." Journal of Experimental Medicine 206, no. 1 (January 12, 2009): 209–19. http://dx.doi.org/10.1084/jem.20082136.

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Human leukocyte antigen (HLA) gene polymorphism plays a critical role in protective immunity, disease susceptibility, autoimmunity, and drug hypersensitivity, yet the basis of how HLA polymorphism influences T cell receptor (TCR) recognition is unclear. We examined how a natural micropolymorphism in HLA-B44, an important and large HLA allelic family, affected antigen recognition. T cell–mediated immunity to an Epstein-Barr virus determinant (EENLLDFVRF) is enhanced when HLA-B*4405 was the presenting allotype compared with HLA-B*4402 or HLA-B*4403, each of which differ by just one amino acid. T

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Posavec, Ana, and Renata Zunec. "Distribution of minor histocompatibility antigens HA-1, HA-2 and HA-8 in the Croatian population." Molecular and experimental biology in medicine 3, no. 1 (June 1, 2020): 29–33. http://dx.doi.org/10.33602/mebm.3.1.5.

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Minor histocompatibility antigens (mHAgs) are polymorphic, endogenously synthetized products recognized by alloreactive T cells in the context of major histocompatibility complex molecules. Recipients of allogeneic bone marrow grafts run the risk of graft-versus-host disease (GvHD), even when the donor is an HLA-identical sibling. This may be caused by disparities in mHAgs between the donor and the recipient, with the antigen present in the recipient and not in the donor. In such cases, T cells in the transplanted donor marrow respond to the recipient’s mHAgs. We determined the allele, genotyp

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Subklewe, Marion, Casper Paludan, Ming L. Tsang, Karsten Mahnke, Ralph M. Steinman, and Christian Münz. "Dendritic Cells Cross-Present Latency Gene Products from Epstein-Barr Virus–Transformed B Cells and Expand Tumor-Reactive Cd8+ Killer T Cells." Journal of Experimental Medicine 193, no. 3 (February 5, 2001): 405–12. http://dx.doi.org/10.1084/jem.193.3.405.

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Dendritic cells (DCs) are not targets for infection by the transforming Epstein-Barr virus (EBV). To test if the adjuvant role of DCs could be harnessed against EBV latency genes by cross-presentation, DCs were allowed to process either autologous or human histocompatibility leukocyte antigen (HLA)-mismatched, transformed, B lymphocyte cell lines (LCLs) that had been subject to apoptotic or necrotic cell death. After phagocytosis of small numbers of either type of dead LCL, which lacked direct immune-stimulatory capacity, DCs could expand CD8+ T cells capable of killing LCLs that were HLA matc

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Luo, Heng, Hao Ye, Hui Wen Ng, Lemming Shi, Weida Tong, Donna L. Mendrick, and Huixiao Hong. "Machine Learning Methods for Predicting HLA-Peptide Binding Activity." Bioinformatics and Biology Insights 9s3 (January 2015): BBI.S29466. http://dx.doi.org/10.4137/bbi.s29466.

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As major histocompatibility complexes in humans, the human leukocyte antigens (HLAs) have important functions to present antigen peptides onto T-cell receptors for immunological recognition and responses. Interpreting and predicting HLA-peptide binding are important to study T-cell epitopes, immune reactions, and the mechanisms of adverse drug reactions. We review different types of machine learning methods and tools that have been used for HLA-peptide binding prediction. We also summarize the descriptors based on which the HLA-peptide binding prediction models have been constructed and discus

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Mishra, Vikash Chandra, Dinesh Chandra, and Vimarsh Raina. "Histocompatibility Testing: A Fundamental Aspect of Renal Transplant Workup." Transplantology 5, no. 2 (May 15, 2024): 85–97. http://dx.doi.org/10.3390/transplantology5020009.

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Histocompatibility testing is pivotal in any renal transplantation workup, aimed at enhancing prospective donor recipient compatibility and improving transplant outcomes. The evolution and advancement of histocompatibility testing, particularly HLA typing, have significantly improved its precision. This study outlines the historical progression from serologic to DNA-based HLA typing, emphasizing the role of HLA proteins in immune response. Anti-HLA antibodies, targeting HLA proteins, pose challenges in renal transplantation. Monitoring and managing these antibodies are critical for renal trans

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