Dissertations / Theses: 'HMAP'

1

Avalos, Ana M. "HMA1 and HMA6 are essential components of metal homeostasis in Arabidopsis thaliana." Link to electronic thesis, 2004. http://www.wpi.edu/Pubs/ETD/Available/etd-0429104-112415.

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Larsson, Rasmus, and Edvard Wikström. "Analysis and implementation of a call simulator for Mobile@Home at Ericsson AB." Thesis, Linköping University, Department of Electrical Engineering, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2629.

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Mobile telephony technology like GSM made portable telephony a possibility. The arising and development of the Internet made a revolutionary change to communication and interchange of information. Bluetooth wireless technology revolutionizes personal connectivity by providing freedom from wired connections. Combining these technologies together brings the concept of Mobile@Home of Ericsson.

Mobile@Home is a fixed-mobile convergence concept using the fixed network to carry present and future mobile services (e.g. voice, video, mail and Internet access) all the way to the home or office. By combining the high bandwidth of the fixed access network with the wireless technology of Bluetooth, Mobile@Home makes it possible to deliver high bandwidth to the mobile phone. Mobile@Home requires a Bluetooth enabled mobile phone and a Bluetooth enabled HBS (Home Base Station), placed at the home or office. By means of fast IP access (ADSL, cable modem etc.) the HBS connects into the standard mobile core network through a HBSC (Home Base Station Controller).

The purpose of this thesis is the generation of simulated traffic between the HBS and HBSC and to analyze its behavior. This primary involves generation of signaling through an internal protocol, provided by Ericsson, for management and call control, and generation of GSM EFR (Enhanced Full Rate) voice streams over the RTP (Real Time Protocol) protocol. The simulation will consist of both the HBS and MS (Mobile Station). A set of HBS: s with attached MS will call one another through the HBSC. In this assignment only the GSM signaling will be considered because of time and scope limitations. The goal is to validate the RTP traffic generated towards the HBSC. Parameters like packet loss, packet delay and erroneous packets will be analyzed.

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3

Frame, Thomas Robert History Australian Defence Force Academy UNSW. "Where fate calls : the HMAS Voyager tragedy." Awarded by:University of New South Wales - Australian Defence Force Academy. School of History, 1991. http://handle.unsw.edu.au/1959.4/38724.

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On 10 February 1964 during naval night exercises off the south coast of Australia, the destroyer HMAS Voyager was lost after colliding with the aircraft carrier HMAS Melbourne. 82 men were killed. Following the collision, there were two Royal Commissions that sustained a political controversy that lasted for over four years. This thesis examines the loss of Voyager as a watershed in the operational and administrative history of the RAN and as a major event in Australian national history. This study has four broad objectives: to describe the loss of Voyager and the long running controversy that accompanied the disaster; to offer a convincing explanation of the causes of the collision and why two royal commissions concluded that the causes for the disaster were inexplicable; to assess the effect on the RAN, in terms of specific reforms and its influence on Service culture and professional ethos, of the disaster and the inquiries that followed; and finally, to analyse the loss of Voyager as a media and political cause celebre in Australian history. As so little has been written about Voyager using primary sources, this thesis was committed to detailed description of events as well as analysis of themes. This thesis draws upon an extensive body of primary source material in the form of official naval and Royal Commission records to which complete access was given; several large collections of private papers; over one hundred interviews with principal participants; and comprehensive files of press cuttings. The discussion seeks to demonstrate that a series of naval accidents preceding the loss of Voyager contributed in a substantial way to shaping the public reaction to, and political handling of, the disaster; that the method of inquiry played a major role in generating public and political disquiet; that the collision was both a catalyst and stimulus to change in naval operations and reform in naval administration; that the inability of two Royal Commissions to ascertain the causes of the collision and then to public suspicion of a cover-up; and, that the collision was most probably caused by the incorrect relaying of a tactical signal on the bridge of Voyager. The loss of HMAS Voyager appears to be a key event in the development of the RAN, not as a direct result of the collision or its causes, but as a consequence of its long and controversial aftermath.

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4

Beres, Joanna M. "Reactions of Silanes and Chlorophosphazenes with HMPA." University of Akron / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=akron1311620295.

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5

Buckland, M. "HMAS Sydney II Commission of Inquiry report on technical aspects of the sinking of HMAS Sydney and HSK Kormoran /." Fishermans Bend, Victoria : Defence Science and Technology Organisation, 2009. http://hdl.handle.net/1947/9862.

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6

Eren, Elif. "HMA2. A Transmembrane Zn2+ Transporting ATPase from Arabidopsis thaliana." Worcester, Mass. : Worcester Polytechnic Institute, 2007. http://www.wpi.edu/Pubs/ETD/Available/etd-010507-150007/.

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7

Hasan, Maysun Mazhar. "Using genetic algorithm to "fool" HMAX object recognition model." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/77013.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2012.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 48-49).
HMAX ("Hierarchical Model and X") system is among the best machine vision approaches developed today, in many object recognition tasks [1]. HMAX decomposes an image into features which are passed to a classifier. These features each capture information about a small section of the input image but might not have information about the overall structure of the image if there is not a significant number of overlapping features. Therefore it can produce a false-positive if two images from two different classes having sufficiently similar features profile but completely different structures. To demonstrate the problem this thesis aimed to show that the features of a given subject are not unique because they lack geometric information. Genetic algorithm (GA) was used to create an image with a similar feature profile as a subject but which clearly does not belong to the subject. Using GA, random pixel images converged to an image whose feature profile has a small Euclidian distance from a target profile. This generated GA image does not resemble the target image but has a similar profile which successfully fooled the classifier in most cases. This implies that the "binding problem" is a major issue in a HMAX model of the size tested. Furthermore, methods of improving the system were investigated.
by Maysun Mazhar Hasan.
M.Eng.

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8

Songate, Joelouis L. "A historical study of the changes in the Hmar society of Manipur resulting from the introduction of Christianity 1910-1935." Online full text .pdf document, available to Fuller patrons only, 1999. http://www.tren.com.

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9

Zou, Jian. "Development and evaluation of an HMA fracture mechanics based model to predict top-down cracking in HMA layers." [Gainesville, Fla.] : University of Florida, 2009. http://purl.fcla.edu/fcla/etd/UFE0041135.

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10

Barlow, David A. "Router-based traffic engineering in MPLS/DiffServ/HMIP radio access networks." Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/15362.

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Yu, Jian. "Synthesis of acylfulvenes and analogs of the antitumor agent hydroxymethylacylfulvene (HMAF) /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1997. http://wwwlib.umi.com/cr/ucsd/fullcit?p9726905.

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12

Coopamah, Malini Devi. "Functions of Hmp, the flavohaemoglobin of Escherichia coli." Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327663.

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13

Eren, Elif. "HMA2. A Transmembrane Zn²⁺ Transporting ATPase from Arabidopsis thaliana." Digital WPI, 2007. https://digitalcommons.wpi.edu/etd-dissertations/6.

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P1B-type ATPases transport a number of monovalent and divalent heavy metals (Cu+, Cu2+, Ag+, Zn2+, Cd2+, Pb2+ and Co+2) across biological membranes. These ATPases are found in archea, bacteria and eukaryotes and are one of the key elements required for maintaining metal homeostasis. Plants have an unusually high number of P1B-type ATPases with distinct metal selectivity compared to other eukaryotes that usually have one or two Cu+-ATPases. Higher plants are the only eukaryotes where Zn2+-ATPases have been identified. Towards understanding the physiological roles of plant Zn2+-ATPases, we characterized Arabidopsis thaliana HMA2. We expressed HMA2 in yeast and measured the metal dependent ATPase activity in membranes. We showed that HMA2 is a Zn2+-ATPase that is also activated by Cd2+. Zn2+ transport determinations showed that this enzyme drives the efflux of metal from the cytoplasm. Analysis of HMA2 mRNA levels showed that the enzyme is present in all plant organs. We analyzed the effect of removal of HMA2 full-length transcript in whole plants by gene knock out. Although hma2 mutants did not show a different visible phenotype from the wild type plants, we observed increased levels of Zn2+ or Cd2+. The observed phenotype of hma2 mutants and plasma membrane location of HMA2, mainly in vasculature (Hussain et al., 2004), indicates that this ATPase might have a central role in Zn2+ uploading into the phloem. P1B-type ATPases have cytoplasmic regulatory metal binding domains (MBDs) in addition to transmembrane metal binding sites (TMBDs). Plant Zn2+-ATPases have distinct sequences in both their N- and C-termini that might contribute to novel metal binding sites. These ATPases contain long C-terminal sequences rich in CC dipeptides and His repeats. Removal of the C-terminus (C-MBD) of HMA2 leads to a 50% reduction in the enzyme turnover suggesting a regulatory role for this domain. Atomic Absorption Spectroscopy (AAS) analysis showed that Zn2+ binds to C-MBD with a stoichiometry of three (3 Zn/C-MBD). Chemical modification studies and Zn K-edge X-ray Absorption Spectroscopy (XAS) of Zn-C-MBD showed that Zn2+ is likely coordinated by His in two sites and the third site slightly differs from the others involving a Cys together with three His. All plant Zn2+-ATPases lack the typical CXXC signature sequences observed in Cu+-ATPases and some bacterial Zn2+-ATPases N-terminus metal binding domains (N-MBDs). Instead, these have conserved CCXXE sequences. Truncation of HMA2 N-MBD results in a 50% decrease in enzyme Vmax suggesting that N-MBD is also a regulatory domain. The results indicate that the N-MBD binds Zn2+ with a stoichiometry of one (1 Zn/N-MBD). Metal binding analysis of individual N-MBD mutants Cys17Ala, Cys18Ala and Glu21Ala/Cys prevented Zn+2 binding to HMA2 N-MBD suggesting the involvement of all these residues in metal coordination. ATPase activity measurements with HMA2 carrying the mutations Cys17Ala, Cys18Ala and Glu21Ala/Cys showed a reduction in the enzyme activity similar to that observed the truncated protein indicating that the enzyme activity reduction observed in the N-terminus truncated forms of the enzyme is related to the removal of the metal binding capability. Summaryzing, these studies show the central role of HMA2 in plant Zn2+ homeostasis. They also describe the mechanism and direction of Zn2+ transport. Finally, they establish the presence of novel metal binding domains in the cytoplasmic portion of the enzyme. Metal binding to these domains is required for full enzymatic activity.

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14

Harmon, Henry Jason. "Computational and Spectroscopic Determination of Lithiated Benzylic Nitriles in THF/HMPA Solution." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/29019.

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The synthetic utility of nitrile-stabilized carbanions as reactive intermediates for selective carbon-carbon bond formation has prompted numerous studies toward characterization of the solution structure of these nucleophiles. In hopes of eventually gaining a better understanding of the structural properties which may mediate reactivity and selectivity, researchers have designed elegant structure elucidation strategies. These studies have offered key advancements toward the characterization of these intermediates; however, contradictory evidence has hindered unambiguous structural determinationâ particularly for lithiated benzylic nitriles in low dielectric, ethereal media. Chapter 1 of this dissertation presents a review of the synthetic utility of metalated nitriles and the spectroscopic and computational techniques employed to characterize their solution structure. Also reviewed herein are the controversial determinations drawn from these efforts. The research and data which follow in Chapters 2 and 3 focus on resolution of the conflicting structural determinations drawn from multinuclear magnetic resonance (NMR) and vibrational (IR and Raman) spectroscopy. Employing a strategy to slow the lithium-nitrogen exchange rate in low dielectric media, new 7Li, 31P, and 15N NMR spectroscopic evidence (with support from computational modeling) lead us to amend our previous assessments and propose that lithiated arylacetonitriles adopt an aggregated triple-ion structure in THF/hexane with sub-stoichiometric HMPA. Due to the limitations of computer resources and the effect of non-linear scaling, theoretical modeling of aggregated and solvated lithiated benzylic nitriles became impractical at the 6-31+G(d) basis set. These limitations led to the use and comparative analysis of two alternative basis sets for the DFT analysis of lithiated benzylic nitrile derivativesâ 6-31(+LiX)G(d) and 6-31â +â G(d). Defined upon the principal of resonance stabilization, these basis sets were constructed by application of varying levels of computational theory on a per-atom basis. By applying higher levels of theory only to the atoms most intimately involved in the electronic distribution, â accurateâ replacement models for 6-31+G(d) structures were obtained with considerable savings in computational resources. This study in basis set economy is detailed fully within Chapters 4 and 5.
Ph. D.

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15

Lin, Sen. "Evaluation of HMA fracture mechanics-based thermal cracking model." Thesis, KTH, Transportvetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-50945.

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Low temperature cracking is an important form of asphalt pavement deterioration in cold regions. The cracks develop when thermally induced stresses exceed the fracture resistance of the asphalt pavement. In this study, by incorporating HMA fracture mechanics into thermal cracking model, a new integrated model is introduced to investigate low temperature cracking performance. To evaluate its reliability and accuracy, the predicted thermally induced stress and failure temperature are compared with the fracture stress and fracture temperature obtained from thermal stress restrained specimen test. The findings indicate that this HMA fracture mechanics-based thermal cracking model has a great potential to reliably evaluate the performance of asphalt mixtures subjected to thermally induced damage.

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Banerji, Prarthana. "Laboratory evaluation of hot mix asphalt (HMA) in Delaware." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 91 p, 2007. http://proquest.umi.com/pqdweb?did=1251904771&sid=2&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Willis, James Richard Turochy Rod E. Parker Frazier. "A statistical analysis of Georgia's HMA quality assurance proccess." Auburn, Ala., 2005. http://repo.lib.auburn.edu/2005%20Fall/Thesis/WILLIS_JAMES_4.pdf.

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Jaoude, Ziad P. Bou. "Laboratory characterization of Nevada's HMA mixtures for mechanistic empirical design." abstract and full text PDF (free order & download UNR users only), 2006. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1438942.

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19

Leiva, Villacorta Fabricio. "Relationships between laboratory measured characteristics of HMA and field compactability." Auburn, Ala., 2007. http://repo.lib.auburn.edu/07M%20Theses/LEIVA_FABRICIO_7.pdf.

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20

Pratheepan, Kandiah. "Use of reclaimed asphalt pavements (RAP) in airfield HMA pavements." abstract and full text PDF (UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1457012.

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21

Vassiliou, Vasos. "An integration framework and a signaling protocol for MPLS/DiffServ/HMIP radio access networks." Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/13732.

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22

Gullberg, David. "Implementation and evaluation of an HMA fracture mechanics based design module." Licentiate thesis, KTH, Väg- och banteknik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-33748.

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A thickness design module for flexible pavements, based on the HMA fracture mechanics framework, has been developed in order to design against premature failure caused by cracking. The HMA fracture mechanics based design module has been evaluated by designing typical Swedish pavements under typical Swedish climate and loading conditions and comparing the results with a reference design framework. The integrated set of material models predicting the necessary material strength- and creep compliance parameters for crack resistance evaluation within this framework has been evaluated against a number of field cores tested. Results show that the design module developed is able to accurately predict cracking in Swedish flexible pavements, indicating that the principles behind the design procedure are fundamental and that the material models used are able to make qualitative predictions of the individual material properties used to estimates a mixtures’ resistance to cracking.

QC 20110518

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23

Whetter, Lindsay. "Faith inside : an ethnographic exploration of Kainos Community, HMP The Verne." Thesis, University of Exeter, 2015. http://hdl.handle.net/10871/22974.

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In April 1997 Kainos Community in HMP The Verne, Dorset, England became the first faith-based prison unit to be established in the Western world. The foundations and ethos of Kainos are based on Christian concepts of ‘loving your neighbour’ and forgiveness. The community operates as a hybrid therapeutic community (TC) and cognitive behavioural programme (CBP). It is open to and inclusive of prisoners of all faiths and none. The aim of this study is to explore the Kainos community ethnographically, guided by the principles of grounded theory and thematic analysis, in order to investigate whether or not Kainos ameliorates some of the de-humanising aspects of prison, and if so, how it rehumanises the prison space. Theoretically, this study highlights the dehumanisation of imprisonment, and illuminates the role that a holistic, Christian-based approach can play in terms of making the prison environment ‘more human’. My findings reveal that on Kainos there are physical, liminal and spiritual spatial mechanisms, in which a family of sub-themes interact to enable flourishing to occur. Kainos has created a physical space in which spaces of architecture and design; sensory experience; movement; and home interact to enable flourishing, whereby prisoners feel ‘more homely’, ‘free’, safe, and calm. Kainos has created a liminal space in which spaces of atmosphere; identity; home; and creativity interact to enable flourishing, empowering prisoners in their self-expression; as a cathartic tool; and as a means of regaining or creating a new identity. Kainos has created a spiritual space in which spaces of Christian activism, love, and forgiveness enable self-worth, healing, transformation, and meaningful change. The implication is that Kainos has created spaces of flourishing, safety and peace within an otherwise dehumanising carceral space, and this plays an important role in the process of transformational change imperative in the desistance process. If society must have prisons, this study concludes that Kainos provides a model for how they should be.

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24

Reising, Nathan Paul. "Progress towards the total synthesis of Hibarimicin B and its congeners." Thesis, Texas A&M University, 2003. http://hdl.handle.net/1969.1/453.

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Hibarimicin B (I) was isolated from a soil sample collected in Hibari, Japan, in 1995, and was identified to be a potent inhibitor of tyrosine kinase via a multi-protein assay. Chapter I of this thesis describes the biological activity of the hibarimicins, in addition to an investigation of the biosynthetic pathway leading to the hibarimicins. Based on this biosynthetic study, we have identified hibarimicinone (II) and HMP-Y1 (III) as key synthetic targets. Chapter II describes a model study investigating the key Hauser annulation for the synthesis of hibarimicinone (II). Synthetic progress towards one of the key intermediates in the synthesis of HMP-Y1 (III) is also presented. Chapter III summarizes the work accomplished to date and provides an overview of the necessary work needed for the total synthesis of hibarimicinone (II) and HMP-Y1 (III).

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25

Wang, Shu. "Optimum Microarchitectures for Neuromorphic Algorithms." University of Dayton / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1323706763.

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26

McGahan, Jeremy. "The development of correlations between HMA pavement performance and aggregate shape properties." Texas A&M University, 2005. http://hdl.handle.net/1969.1/3351.

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The physical characteristics of aggregates (form, angularity, and texture) are known to affect the performance of hot mix asphalt (HMA) pavements. Efforts to develop relationships between these aggregate characteristics and aggregate performance in HMA pavements have been limited in the past due to inherent inaccuracies in the methods used to measure these characteristics. The recently developed Aggregate Imaging System (AIMS) offers an opportunity to accurately measure aggregate shape characteristics allowing them to be properly related to asphalt performance. This research focused on relating the aggregate characteristics of form, angularity, and texture measured using AIMS to laboratory performance measurements on a wide variety of HMA mixes. The performance of these mixes was evaluated in three projects carried out by the Federal Highway Administration (FHWA) and the Texas Transportation Institute (TTI). During this research, a database of the volumetric, performance, and aggregate shape measurements for mixes used in these projects was created. Statistical analysis was conducted to correlate HMA performance parameters to volumetric and aggregate shape characteristics. The results show the dominant effect that aggregate shape properties have on HMA performance.

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27

Gebremeskel, Kiflat Yohannes. "The effect of filler type and shape on HMA energy dissipation performance." Thesis, KTH, Väg- och banteknik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-127706.

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Hot mix asphalt pavements require adequate compaction to achieve the required density to resist rutting. The amount of energy required to achieve the optimum degree of compaction depends on the type of gradation, bitumen content, filler type and shape, type of compaction equipment etc. In this study, the net energy required to reduce the specimen volume (size) after each gyration of the superpave gyratory compactor is used as the compaction energy index (CEI) to measure the compactability of the samples. Samples with different filler types and content are used for the analysis. Effect of fillers on the viscosity of the mastic has been studied previously. Viscosity of mastics in return affects the compactability of the mix in general. In this regard this paper tries to study the effect of fillers on the compaction of hot mix asphalt with the help of the superpave gyratory compactor. Moreover, resistance of the asphalt mix samples against rutting is evaluated using the simple performance test. In this test, the sample is subjected to a hydraulic loading while strain transducers attached to the sample measure the displacement. A computer program receives the displacement data at various frequencies and calculates the dynamic modulus and flow number which are used for the evaluation of the pavement performance. :

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Sequeira, Wendy. "Impact of lime on the mechanical properties of HMA mixtures in Nevada." abstract and full text PDF (UNR users only), 2009. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1472978.

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29

Arepalli, Uma Maheswar. "A Study of Moisture Induced Material Loss of Hot Mix Asphalt (HMA)." Digital WPI, 2017. https://digitalcommons.wpi.edu/etd-dissertations/409.

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"Susceptibility of Hot Mix Asphalt (HMA) mixes to moisture induced damage is one of the main reasons for premature failures of asphalt pavements. Hence, the evaluation of mixes for the moisture susceptibility is an essential part of the mix design. The existing methods are found to be in-sufficient to characterize mixes in terms of their moisture damage potential, and many studies have been conducted to establish an improved methodology that can better address the issue. Most of these methods involve the determination of changes in mix properties due to moisture conditioning in the laboratory or to verify the mix performance in the field or the laboratory. In the field moisture susceptible mixes are also found to lose material to extents that are dependent upon the properties of the mix and materials. So far, there has been no comprehensive study to investigate the loss of materials due to moisture induced damage. The objective of this study was to identify and evaluate a conditioning and a test method that can be used on a regular basis to detect moisture susceptible mixes and to understand the combined problem of moisture induced material loss and change in strength/stiffness of the mix. The Moisture Induced Stress Tester (MIST), Ultrasonic Pulse Velocity (UPV), Dynamic Modulus in Indirect tensile mode, and Indirect Tensile Strength (ITS) tests were utilized in the study. The effluent from the MIST was checked for the gradation of dislodged aggregates and the Dissolved Organic Carbon (DOC) content. A system dynamics (SD) approach was also adopted to investigate the problem and establish a model to reproduce field observations. The results showed that the use of MIST in combination with UPV or ITS is able to identify moisture susceptible mixes, in particular for mixes with the potential of aggregate breakdown. The mixes with a higher loss of asphalt binder during conditioning exhibit higher tensile strengths, and those with a loss of finer materials, which is indicative of aggregate breakdown, show a lower tensile strength. For the mixes used in this study, the rate of change in indirect tensile strength during moisture conditioning was found to be strongly correlated to the pre-conditioning modulus of the mix. A step-by-step framework to characterize the moisture susceptible mixes was presented."

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Diefenderfer, Stacey D. "Investigation of Fatigue Properties of Superpave HMA at the Virginia Smart Road." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/29538.

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This study investigated the influence of material properties on fatigue life through laboratory fatigue testing of eleven Superpave hot mix asphalt (HMA) mixtures in use at the Virginia Smart Road. Mixtures were sampled from the plant and produced in the laboratory to investigate the influence of production method. Specimens were cut from the in-situ pavement and compacted in the laboratory to evaluate the influence of compaction method. Third point beam fatigue testing was performed at 25ÂºC and 10Hz. Additional testing at frequencies of 1 Hz and 5Hz, and at 10 Hz including rest periods of 0.4sec and 0.9sec were performed for one mixture to explore the impact of frequency and rest periods. Analyses were performed on the strain-life relationships and predicted endurance strain limits for the mixtures. Investigation of strain-life relationships for several mixtures indicated that small differences in mixture volumetrics due to the production method have minimal impact on the laboratory fatigue performance of HMA. Comparisons of expected fatigue performance for one mixture indicated that shorter fatigue lives (under the same strain conditions) may be expected for laboratory-compacted specimens when compared to field-compacted specimens, despite visual observation of damage (surface cracking) in the field-compacted specimens. Testing performed on one mixture to determine the influence of different loading frequencies showed that fatigue life was independent of the requencies tested. Investigation of rest period inclusion indicated no differences in fatigue life for loading conducted at 10 Hz frequency and no rest period, 0.4sec rest period, or 0.9sec rest period. The evaluation of specimens cut from the in-situ pavement indicated that location within the lane and orientation did not significantly affect laboratory fatigue performance. The effect of aggregate size was considered; however, results were inconclusive. Using predictive strain-life fatigue equations, the benefits of polymer-modification of binders and use of SMA were shown for mixtures produced in the laboratory according to the job mix formula and to match the plant-produced volumetrics. Evaluation of the predicted fatigue strain endurance limit was performed using an energy-based and an empirical method. The energy method was shown to estimate significantly higher endurance limit strains for mixtures.
Ph. D.

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31

Walubita, Lubinda F. "Comparison of fatigue analysis approaches for predicting fatigue lives of hot-mix asphalt concrete (HMAC) mixtures." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/3898.

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Hot-mix asphalt concrete (HMAC) mixture fatigue characterization constitutes a fundamental component of HMAC pavement structural design and analysis to ensure adequate field fatigue performance. HMAC is a heterogeneous complex composite material of air, binder, and aggregate that behaves in a non-linear elasto-viscoplastic manner, exhibits anisotropic behavior, ages with time, and heals during traffic loading rest periods and changing environmental conditions. Comprehensive HMAC mixture fatigue analysis approaches that take into account this complex nature of HMAC are thus needed to ensure adequate field fatigue performance. In this study, four fatigue analysis approaches; the mechanistic empirical (ME), the calibrated mechanistic with (CMSE) and without (CM) surface energy measurements, and the proposed NCHRP 1-37A 2002 Pavement Design Guide (MEPDG) were comparatively evaluated and utilized to characterize the fatigue resistance of two Texas HMAC mixtures in the laboratory, including investigating the effects of binder oxidative aging. Although the results were comparable, the CMSE/CM approaches exhibited greater flexibility and potential to discretely account for most of the fundamental material properties (including fracture, aging, healing, visco-elasticity, and anisotropy) that affect HMAC pavement fatigue performance. Compared to the other approaches, which are mechanistic-empirically based, the CMSE/CM approaches are based on the fundamental concepts of continuum micromechanics and energy theory.

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Cun, Pierre. "Etude des HMAS A Zn2+/Cd2+/Co2+/Pb2+ chez Arabidopsis thaliana, du rôle physiologique à la structure." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4025/document.

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Les travaux présentés ici portent sur les P1B-ATPases HMA2, HMA3 et HMA4 d'Arabidopsis thaliana, transporteurs de cations présents sur différentes membranes chez les plantes. L'étude du contenu cationique de plantes mutantes hma2 et hma4 a précisé le rôle important de HMA4 dans la translocation du Zn et du Cd vers les parties aériennes et sa forte affinité pour le Cd. La mesure du contenu cationique de graines de différents génotypes a montré un effet complexe des modulations de l'expression des gènes correspondants, la surexpression du gène HMA4 conduisant à une teneur en Zn de la graine similaire à celle du mutant perte de fonction. Ces résultats confirment l'importance de HMA4, et montrent la nécessité d'adapter la construction aux objectifs biotechnologiques visés. Afin de préciser le rôle de résidus conservés au sein de la famille des P1B-ATPases, j'ai étudié l'effet de l'expression d'un variant de HMA4 pour le domaine fortement conservé CPC. Les résultats obtenus in planta suggèrent une interaction avec la version native du transporteur entraînant une perte de l'activité de HMA4. Pour mener une approche structure/fonction sur ces transporteurs, L. lactis a été défini comme le meilleur candidat pour produire HMA3. Suite à l'expression de HMA3, un gain de tolérance au Cd a été observé et a permis de valider 3 variants de HMA3, mutés au niveau du pore ou du site d'hydrolyse de l'ATP, comme affectés dans l'activité de la protéine. Les membranes de L. lactis enrichies en transporteur HMA3 ou de ses variants ont permis une reconstitution in vitro en protéoliposomes permettant de mesurer une activité de transport du Cd compétitive avec le Zn et inhibée par le vanadate
Work presented here is about Arabidopsis thaliana P1B-ATPases HMA2, HMA3 et HMA4, cation transporters found in different plant membranes. Cation content study of mutant plants hma2 and hma4 precised important role of HMA4 in upward translocation of Zn and Cd, and its high affinity for Cd. Cation content measure of seeds from different genotypes showed a complex effect of modulations of related genes expression levels, HMA4 overexpression leading to a seed Zn content similar the loss-of-function mutant one. These results confirm the importance of HMA4 and show the needs to adapt construction to biotechnological aims. To precise the role of residus conserved among the P1B-ATPases family, I studied the effect of the expression of a HMA4 variant for the highly conserved domain CPC. Obtained in planta results suggest an interaction with the native transporter leading to a loss of HMA4 activité. To perform a structure/function study on these transporters, L.lactis has been shown as the best candidate to produce HMA3. Due to HMA3 expression, a gain of Cd tolerance has been observed and allowed to validate three HMA3 variants, mutated in the pore or the ATP hydrolysis site, as affected in the protein activity. L.lactis membranes enriched with HMA3 or variants allowed an in vitro reconstitution in proteoliposomes and the measurement of a Cd transport activity competing with Zn and inhibited by vanadate

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Bernard, Catherine. "Identification of genes in Thlaspi caerulescens, potentially involved in cadmium detoxification and transport :characterization of Tc-HMA4." Doctoral thesis, Universite Libre de Bruxelles, 2004. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211162.

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Reyes, Jaime. "Quantifying the role of coarse aggregate strength on resistance to load in HMA." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2007. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

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35

Jung, Sung Hoon. "The effects of asphalt binder oxidation on hot mix asphalt concrete mixture rheology and fatigue performance." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1754.

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36

Hoffmann, Toni. "Cloning and characterisation of the HMA3 gene and its promoter from Arabidopsis halleri (L.) O'Kane and Al'Shehbaz and Arabidopsis thaliana (L.) Heynhold." Phd thesis, kostenfrei, 2007. http://opus.kobv.de/ubp/volltexte/2007/1525/.

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37

Zhu, Feng. "Developing Simple Lab Test To Evaluate HMA Resistance To Moisture, Rutting, Thermal Cracking Distress." University of Akron / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1204879659.

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38

Stevanin, Tania Maria. "Bacterial flavohaemoglobins : physiological function and responses to nitrosative stress." Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340137.

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39

Ofori-Abebresse, Edward Kwame. "Fatigue resistance of hot-mix asphalt concrete (HMAC) mixtures using the calibrated mechanistic with surface energy (CMSE) measurements approach." Thesis, Texas A&M University, 2006. http://hdl.handle.net/1969.1/4136.

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Fatigue cracking is one of the fundamental distresses that occur in the life of a Hot Mix Asphalt Concrete (HMAC) pavement. This load induced distress leads to structural collapse of the entire pavement ultimately and can only be remedied by rehabilitation. There is the need, therefore, for a total understanding of the phenomenon to be able to counter its occurrence. The fatigue resistance of hot mix asphalt concrete (HMAC) has been estimated using approaches ranging from empirical methods to mechanistic-empirical methods to purely mechanistic methods. A continuum mechanics based approach called the Calibrated Mechanistic with Surface Energy (CMSE) measurements was developed at Texas A&M University and recommended after comparison with other approaches in predicting fatigue lives of two Texas HMAC mixtures. The CMSE approach which includes fundamental material properties such as fracture, aging, healing, and anisotropy has been shown to effectively model the parameters that affect the performance of HMAC pavements exposed to repetitive traffic loads. Polymer modified asphalt (PMA) improves pavement performance by providing additional resistance to the primary distresses in flexible pavements, including permanent deformation or rutting, thermal cracking, and fatigue cracking. In this research, the CMSE approach was utilized to estimate the fatigue resistance of HMAC fabricated with asphalts modified with Styrene-butadiene-Styrene (SBS) co-block polymer. These HMAC mixtures were fabricated from materials used on three different road sections in Texas and one test pavement in Minnesota. The CMSE approach was validated as an effective approach for estimating the fatigue resistance of HMAC mixtures with PMA. The effect of oxidative aging on the fatigue resistance of the HMAC mixtures was also verified. Oxidative aging of the mixtures resulted in a corresponding decrease in mixture fatigue resistance. In addition, for two HMAC mixtures with the same binder content and aggregate gradation, the mixture with the softer of the two Performance Grade (PG) binders exhibited greater fatigue resistance. The use of the Utility Theory revealed the possible effects of aggregate geometric properties on the HMAC mixture properties and consequently on their fatigue resistance.

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40

Mitchell, Jonathan Philip. "Exploring views about mental health problems and helpseeking amongst adult male prisoners at HMP Leeds." Thesis, University of Leeds, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487745.

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In the last few decades, the prison population has risen rapidly and now stands at over 82,000. Research suggests that up to 90% of prisoners have some kind of mental disorder or abuse substances (Singleton, Meltzer, Gatward, Coid, & Deasy, 1998). Significant recent attempts have been made to improve prison-based mental health services (HM Inspectorate of Prisons, 2007). However, very little is known about how prisoners themselves construe mental health problems, or which help-sources they would turn to if they experienced difficulties.

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41

Nanagiri, Yamini Varma. "Development of a rational method of designing hot mix asphalt (HMA) for low volume roads." Link to electronic thesis, 2005. http://www.wpi.edu/Pubs/ETD/Available/etd-01055-115823/.

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42

Lien, Lal Dawm. "A biblical response to the traditional worldviews and practices of the Hmars." Theological Research Exchange Network (TREN), 1993. http://www.tren.com.

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43

Boutigny, Sylvain. "Quelques observations sur le rôle des ATPases à cuivre HMA1 et PAA1 dans le contrôle de l'homéostasie du cuivre chloroplastique." Phd thesis, Université Joseph Fourier (Grenoble), 2009. http://tel.archives-ouvertes.fr/tel-00538124.

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Le chloroplaste est un organite spécifique de la cellule végétale. Il est délimité par une double membrane ou enveloppe qui renferme de nombreux systèmes de transports d'ions et de métabolites essentiels au fonctionnement du chloroplaste et de la cellule végétale. A ce jour, seuls quelques transporteurs de métaux associés à l'enveloppe des plastes ont été identifiés : un transporteur de fer, un transporteur de magnésium ainsi que deux ATPases à cuivre de type P1B : HMA1 et PAA1. PAA1 représenterait la voie principale d'import du cuivre dans le chloroplaste, notamment pour alimenter la photosynthèse. HMA1 constituerait une voie additionnelle d'import du cuivre, voie essentielle pour répondre à un stress oxydatif qui apparaît en particulier lorsque la plante est cultivée en lumière forte. Afin de mieux comprendre les rôles respectifs de ces deux ATPases dans la régulation de l'homéostasie du cuivre chloroplastique, deux approches complémentaires ont été développées : - une approche in planta visant à produire de nouvelles lignées affectées dans l'expression de l'une (mutant paa1 surexprimant HMA1) ou de ces deux ATPases (double mutant hma1/paa1), puis à identifier des conditions (stress lumineux, stress salin, excès de métaux) révélant le rôle essentiel de ces ATPases ou induisant une réponse transcriptionnelle différente des gènes codant ces ATPases ou d'autres acteurs liés à l'homéostasie du cuivre... Les résultats obtenus montrent que la fonction de HMA1, connue pour être essentielle lors d'un stress lumineux, est aussi requise lorsque la plante subit un stress salin. Ces résultats confortent le rôle de HMA1 dans la délivrance du cuivre à la superoxyde dismutase (cuivre/zinc) du chloroplaste. D'autre part, nous avons montré qu'en condition de culture photoautotrophe, le cuivre permet de supprimer partiellement la photosensibilité du mutant hma1, validant ainsi l'implication de HMA1 dans l'homéostasie du cuivre. Nous avons aussi démontré que les fonctions de HMA1 et PAA1 ne sont pas redondantes. Le cuivre importé par ces deux ATPases est probablement délivré à des protéines cibles par des voies différentes. Enfin, nous avons montré qu'il existe une troisième voie d'import de cuivre dans le chloroplaste, voie encore non caractérisée. - une approche in vitro visant à produire ces deux ATPases HMA1 et PAA1 dans le système hétérologue Lactococcus lactis afin de déterminer leurs spécificités ioniques et leurs caractéristiques biochimiques. Le système d'expression procaryote L. lactis a été mis en place au laboratoire et s'avère parfaitement adapté à la production de protéines membranaires de plantes. Ce système a permis de produire plusieurs protéines membranaires d'Arabidopsis, dont HMA1 et PAA1, en quantités compatibles avec des analyses biochimiques. Nous avons déterminé les conditions de solubilisation et de purification de ces deux protéines. Nous n'avons pas pu mesurer d'activité ATPase associée à ces protéines. En revanche, nos données indiquent que ces deux protéines recombinantes peuvent lier l'un de leur substrat ; l'ATP. Nous avons aussi pu démontrer que PAA1 peut lier du cuivre sous forme 1+ et sous forme 2+. Au bilan, ces données suggèrent que le contrôle de l'homéostasie du cuivre chloroplastique requiert plusieurs systèmes de transport indépendants et une régulation fine de ces voies d'import de cuivre afin d'alimenter les besoins liés à la photosynthèse et les besoins liés aux mécanismes de résistance aux stress oxydatifs.

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Ma, James Minh. "Chemical tuning of [Ni(hmp)(ROH)Cl]₄ single molecule magnets and their self assembly onto gold." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p1459289.

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Thesis (M.S.)--University of California, San Diego, 2008.
Title from first page of PDF file (viewed Nov. 10, 2008). Available via ProQuest Digital Dissertations. Includes bibliographical references.

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45

Babadopulos, Lucas Feitosa de Albuquerque Lima. "A Contribution to couple aging to hot mix asphalt (HMA) mechanical characterization under load-induced damage." reponame:Repositório Institucional da UFC, 2014. http://www.repositorio.ufc.br/handle/riufc/11164.

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BABADOPULOS, L. F. A. L. A Contribution to couple aging to hot mix asphalt (HMA) mechanical characterization under load-induced damage. 2014. 139 f. Dissertação (Mestrado em Engenharia de Transportes) – Centro de Tecnologia, Universidade Federal do Ceará, Fortaleza, 2014.
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Although aging simulation in binder is performed through RTFO and PAV tests, n o considerations of asphalt mixture aging are made in regular laboratory characterization. T he present work is focused in incorporating aging to the modeling of the mechanical behavior of hot mix asphalt (HMA) during load - induced damage. This is accomplished by combining existing models and the adaptation of mixture aging procedures . The aging model used is based on the evolution of an internal state v ariable, associated to oxygen availability, aging temperature a nd four material parameters. The se parameters are related to aging susceptibility , reaction kinetics and dependency on aging history and on aging temperature. The model allows to establish relation ship s between different aging processes. Results at four aging states (using two different temperatures) we re analyzed and the aging model parameters w ere estimated. Capturing aging dependency on temperature constitutes a contribution of the presen t work with respect to previous results reported in the literature . T he aging model is coupled to viscoplasticity and damage, comparing the behavior observed at the different aging states. Concerning the damage models, t his thesis used mechanical models de rived from Schapery's work potential theory to model fatigue behavior . T he Simplified Viscoelastic Continuum Damage (S - VECD) model was selected . U nconfined dynamic creep tests were used to evaluate the effect of aging in the mixture resistance to permanent deformation. In addition to the state - of - the - art modeling of HMA, the characterization methods currently in use in Brazil (tensile strength, resilient modulus and controlled force indirect tensile fatigue tests) were also conducted . T he possibility to sim ulate the material behavior for various loading conditions constitutes a n advantage of the state - of - the - art model over the state - of - the practice method for fatigue characterization, used primarily to rank mixtures. It was concluded that, depending on pavem ent conditions and layer geometry, aging not necessarily affects negatively the fatigue behavior, while certainly improving the permanent deformation characteristics. That happens de s pite the fact that aging produces less damage tolerant materials, i.e., m aterials that fail for less evolved damage states. T he framework ( testing and analysis) for damage characterization of asphalt mixtures was implemented and it is expected to contribute to further developments in aging modeling of asphalt mixtures
Apesar de simulação de envelhecimento ser realizada em ligantes asfálticos através dos ensaios de RTFOT e PAV, nenhuma consideração sobre envelhecimento de misturas é feita na caracterização laboratorial comum. O presente trabalho se concentra na incorporação do envelhecimento na modelagem do comportamento mecânico de concretos asfálticos (CA) para carregamentos que induzem dano. Isto é feito através da combinação de modelos e da adaptação de procedimentos de envelhecimento existentes. O modelo de envelhecimento utilizado se baseia na evolução de uma variável interna de estado e é associado à disponibilidade de oxigênio, à temperatura e a quatro parâmetros materiais. Estes parâmetros são relacionados à susceptibilidade ao envelhecimento, à cinética de reação e à dependência sobre o histórico e sobre a temperatura de envelhecimento. O modelo permite estabelecer relações entre diferentes processos de envelhecimento. Resultados em quatro estados de envelhecimento (em duas temperaturas diferentes) foram analisados, e os parâmetros do modelo estimados. Capturar a dependência do processo quanto à temperatura constitui uma contribuição do trabalho quanto a resultados da literatura. O modelo de envelhecimento é acoplado à resposta viscoplástica e ao dano, comparando-se o comportamento nos diferentes estados. Quanto aos modelos de dano, esta dissertação trata dos derivados da teoria do potencial de trabalho de Schapery para análise da fadiga. O modelo simplificado de dano contínuo em meio viscoelástico (S-VECD) foi selecionado. Ensaios de Creep Dinâmico não confinado foram utilizados para avaliar o efeito do envelhecimento na resistência à deformação permanente. Além da modelagem mecânica do comportamento do CA usando modelos do Estado da Arte, também foram executados métodos de caracterização em uso no Brasil (resistência à tração, módulo de resiliência e ensaios de fadiga por compressão diametral). A possibilidade de se simular a resposta do material em várias condições de carga constitui uma vantagem do método do Estado da Arte sobre o do Estado da Prática, usado principalmente para comparar misturas. Concluiu-se que, dependendo das condições do pavimento e da geometria das camadas, o envelhecimento não necessariamente diminui a resistência à fadiga, embora certamente melhore a resistência à deformação permanente. Isso acontece apesar de o envelhecimento produzir materiais menos tolerantes ao dano, i.e., materiais que rompem para estados de dano menos evoluídos. O procedimento para a caracterização do dano em misturas asfálticas foi implementado e espera-se ter contribuído para um maior desenvolvimento da modelagem de misturas quanto ao envelhecimento.

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46

Van, Horn Nicholas M. "Limitations of using bags of complex features: Hierarchical higher-order filters fail to capture spatial configurations." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306869257.

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47

Al, Omari Aslam Ali Mufleh. "Analysis of HMA permeability through microstructure characterization and simulation of fluid flow in X-ray CT images." Texas A&M University, 2004. http://hdl.handle.net/1969.1/1454.

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The infiltration of water in asphalt pavements promotes moisture damage primarily through damaging the binder cohesive bond and the adhesive bond between aggregates and binder. Moisture damage is associated with excessive deflection, cracking, and rutting. The first step in addressing the problems caused by the presence of water within pavement systems is quantifying the permeability of hot mix asphalt (HMA) mixes. This dissertation deals with the development of empirical-analytical and numerical approaches for predicting the permeability of HMA. Both approaches rely on the analysis of air void distribution within the HMA microstructure. The empirical-analytical approach relies on the development of modified forms of the Kozeny-Carman equation and determining the material properties involved in this equation through three dimensional microstructure analyses of X-ray Computed Tomography (CT) images. These properties include connected percent air voids (effective porosity), tortuosity, and air void specific surface area. A database of materials and permeability measurements was used to verify the developed predicting equation. The numerical approach, which is the main focus of this study, includes the development of a finite difference numerical simulation model to simulate the steady incompressible fluid flow in HMA. The model uses the non-staggered system that utilizes only one cell to solve for all governing equations, and it is applicable for cell Reynolds number (Rec) values that are not restricted by |Rec|≤2. The validity of the numerical model is verified through comparisons with closed-form solutions for idealized microstructure. The numerical model was used to find the components of the three-dimensional (3-D) permeability tensor and permeability anisotropy values for different types of HMA mixes. It was found that the principal permeability directions values are almost in the horizontal and vertical directions with the maximum permeability being in the horizontal direction.

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Vidigal, Dimas Jose Araujo. "Efeito da finasterida no antígeno prostático específico (PSA) sérico e na próstata do Hamster - Mesocricetus Auratus (HMA)." Universidade Federal de Minas Gerais, 2010. http://hdl.handle.net/1843/BUOS-8GRMZC.

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Avaliar o efeito da finasterida no PSA sérico e na próstata hMa. Métodos: Vinte hMa adultos, machos, foram divididos em grupos de dez animais: dez animais para o grupo-finasterida e dez animais para o grupo-controle. No grupo-finasterida foram administrados 7,14 ng/mL de finasterida, subcutâneo (SC), no dorso, dose equivalente a 1.000 vezes menor a que é administrada a um homem adulto de 70Kg por noventa dias. Após serem mortos por hipovolemia no momento da colheita do sangue para dosagem do PSA sérico pela técnica ELISA, os animais foram submetidos à laparotomia, e as próstatas foram retiradas em monobloco, dissecadas e fixadas em formalina a 10% e submetidas a estudo por microscopia óptica de luz e estudo morfométrico. Foi avaliado o diâmetro dos ácinos e do epitélio acinar prostático, a apoptose, a expressão AgNORs e a celularidade. Resultados: Ao final da pesquisa, o grupo-finasterida apresentou idade média de 17,7 ± 0,67 meses. O grupo-controle apresentou idade média de 15,2 ±1,13 meses. O valor de t na comparação das médias das idades entre os dois grupos foi de 5,98 e p= 0,001. O grupo-controle pesou em média 129 ± 18,82g e o grupo-finasterida 145,0 ± 15,27g; t = 2,08 e p= 0,0514. O grupo-finasterida apresentou média de PSA de 0,003 ng/mL±0,0048, mediana de 0,003 e o grupo-controle apresentou média de 0,633 ng/mL ± 0,763, mediana de 0,634, H= 7,98 e p= 0,0047. A área dos ácinos do grupo-controle foi de 398,6 ± 55,32 x 103 m2 e 238 ±24,6 x 10 3 m2 para o grupo-finasterida; t= 2,653; p= 0,0122. A área do epitélio acinar foi de 160,4 ±18,43 m2 x 103 para o grupo-controle versus 111,9 ±12,82 m2 x 103 para o grupo-finasterida; t= 2,162; p= 0,0361. A expressão de AgNORs foi menor no grupo-finasterida. Os animais do grupo-controle apresentaram média de 3,68 ± 1,07 grumos de argirófilos/m2, mediana= 4 e os animais do grupo-finasterida apresentaram média de 2,846 ± 0,877 grumos argirófilos/m2 e mediana= 3, p= < 0,0001. A apoptose foi mais frequente no grupo-finasterida, 53,62±1,389 versus grupo-controle, 14,76 ± 2,137, p= 0,0408. Não houve diferença na celularidade entre os grupos de animais, 74,75±5,5 células no grupo-controle versus 65,07±13,24, no grupo-finasterida, p= 0,5105. Conclusão: O uso da finasterida, diminuiu o PSA sérico, as áreas dos ácinos e do epitélio acinar a expressão de AgNORs e promoveu a apoptose nos ácinos da próstata dos hMa que fizeram uso desse medicamento. Não houve diferença significativa na celularidade acinar entre os dois grupos de animais estudados.
Avaliar o efeito da finasterida no PSA sérico e na próstata hMa. Métodos: Vinte hMa adultos, machos, foram divididos em grupos de dez animais: dez animais para o grupo-finasterida e dez animais para o grupo-controle. No grupo-finasterida foram administrados 7,14 ng/mL de finasterida, subcutâneo (SC), no dorso, dose equivalente a 1.000 vezes menor a que é administrada a um homem adulto de 70Kg por noventa dias. Após serem mortos por hipovolemia no momento da colheita do sangue para dosagem do PSA sérico pela técnica ELISA, os animais foram submetidos à laparotomia, e as próstatas foram retiradas em monobloco, dissecadas e fixadas em formalina a 10% e submetidas a estudo por microscopia óptica de luz e estudo morfométrico. Foi avaliado o diâmetro dos ácinos e do epitélio acinar prostático, a apoptose, a expressão AgNORs e a celularidade. Resultados: Ao final da pesquisa, o grupo-finasterida apresentou idade média de 17,7 ± 0,67 meses. O grupo-controle apresentou idade média de 15,2 ±1,13 meses. O valor de t na comparação das médias das idades entre os dois grupos foi de 5,98 e p= 0,001. O grupo-controle pesou em média 129 ± 18,82g e o grupo-finasterida 145,0 ± 15,27g; t = 2,08 e p= 0,0514. O grupo-finasterida apresentou média de PSA de 0,003 ng/mL±0,0048, mediana de 0,003 e o grupo-controle apresentou média de 0,633 ng/mL ± 0,763, mediana de 0,634, H= 7,98 e p= 0,0047. A área dos ácinos do grupo-controle foi de 398,6 ± 55,32 x 103 m2 e 238 ±24,6 x 10 3 m2 para o grupo-finasterida; t= 2,653; p= 0,0122. A área do epitélio acinar foi de 160,4 ±18,43 m2 x 103 para o grupo-controle versus 111,9 ±12,82 m2 x 103 para o grupo-finasterida; t= 2,162; p= 0,0361. A expressão de AgNORs foi menor no grupo-finasterida. Os animais do grupo-controle apresentaram média de 3,68 ± 1,07 grumos de argirófilos/m2, mediana= 4 e os animais do grupo-finasterida apresentaram média de 2,846 ± 0,877 grumos argirófilos/m2 e mediana= 3, p= < 0,0001. A apoptose foi mais frequente no grupo-finasterida, 53,62±1,389 versus grupo-controle, 14,76 ± 2,137, p= 0,0408. Não houve diferença na celularidade entre os grupos de animais, 74,75±5,5 células no grupo-controle versus 65,07±13,24, no grupo-finasterida, p= 0,5105. Conclusão: O uso da finasterida, diminuiu o PSA sérico, as áreas dos ácinos e do epitélio acinar a expressão de AgNORs e promoveu a apoptose nos ácinos da próstata dos hMa que fizeram uso desse medicamento. Não houve diferença significativa na celularidade acinar entre os dois grupos de animais estudados.

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Shannon, Cory Patrick. "Fractionation of recycled asphalt pavement materials: improvement of volumetric mix design driteria for High-RAP content surface mixtures." Thesis, University of Iowa, 2012. https://ir.uiowa.edu/etd/3380.

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The objective of this research is to examine the effects that different methods of RAP stockpile fractionation have on the volumetric mix design properties for high-RAP content surface mixes, with the goal of meeting all specified criteria for standard HMA mix designs. The processing of RAP materials results in the degradation of the aggregate structure of the original pavement. The increased presence of fine RAP materials in the stockpile can be attributed to the amount of crushing done on the RAP millings. Fractionation methods were designed to separate the stockpile at certain sizes to isolate the fine RAP materials which contained higher amounts of fine aggregate and negatively impacted the volumetric properties of the mix design. These isolated RAP materials were used in reduced proportions or completely eliminated, thereby decreasing the amount of fine aggregate material introduced to the mix. Mix designs were created using RAP materials included from each original stockpile and the two fractionated stockpiles created from each original stockpile at high-RAP contents of 30%, 40% and 50% by virgin binder replacement. Fractionation of RAP materials was effective in improving the volumetric properties of high-RAP content mixtures through reduction of fine aggregate material introduced by the RAP materials.

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Arefin, Mir Shahnewaz. "EVALUATION OF THE RELIABILITY ANALYSIS APPROACH IN THE MECHANISTIC-EMPIRICAL PAVEMENT DESIGN GUIDE." University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron1555623389749493.

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Dissertations / Theses on the topic 'HMAP'

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