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Journal articles on the topic 'HML-6'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 March 2023

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1

Mavrommatis, Alexandros, Christina Mitsiopoulou, Christos Christodoulou, et al. "Effects of Supplementing Rumen-Protected Methionine and Lysine on Milk Performance and Oxidative Status of Dairy Ewes." Antioxidants 10, no. 5 (2021): 654. http://dx.doi.org/10.3390/antiox10050654.

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There is limited information on the impact of dietary supplementation with separate rumen-protected (RP) amino acids (AA), or with their combination, on ewes’ oxidative status. Sixty ewes were divided into five groups; C: basal diet (control); M: basal diet + 6 g/ewe RP methionine; L: basal diet + 5 g/ewe RP lysine; LML: basal diet + 6 g methionine and 5 g lysine/ewe; and HML: basal diet + 12 g methionine + 5 g lysine/ewe. Milk’s fat content increased in RP-AA fed ewes, while that of protein in M and L only. In blood plasma, the malondialdehyde (MDA) content was reduced in the M, LML, and HML

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Shah, Ashish, Vaidya Govindarajan, Tara Doucet-O'Hare, et al. "EPCO-33. DIFFERENTIAL EXPRESSION OF AN ENDOGENOUS RETROVIRAL ELEMENT [HERV-K(HML-6)] IS ASSOCIATED WITH REDUCED SURVIVAL IN GLIOBLASTOMA PATIENTS." Neuro-Oncology 24, Supplement_7 (2022): vii123. http://dx.doi.org/10.1093/neuonc/noac209.467.

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Abstract INTRODUCTION Comprising approximately 8% of our genome, Human Endogenous RetroViruses (HERVs) represent a class of germline retroviral infections that are regulated through epigenetic modifications. In cancer cells, which often have epigenetic dysregulation, HERVs have been implicated as potential oncogenic drivers. However, their role in gliomas is not known.Given the link between HERV expression in cancer cell lines and the distinct epigenetic dysregulation in gliomas, we utilized a tailored bioinformatic pipeline to characterize and validate the glioma retrotranscriptome and correl

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3

Wehling, M., D. Armanini, T. Strasser, and P. C. Weber. "Effect of aldosterone on sodium and potassium concentrations in human mononuclear leukocytes." American Journal of Physiology-Endocrinology and Metabolism 252, no. 4 (1987): E505—E508. http://dx.doi.org/10.1152/ajpendo.1987.252.4.e505.

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The in vitro effect of aldosterone on intracellular sodium and potassium concentration was investigated in human mononuclear leukocytes (HML). HML were separated from blood by a Percoll gradient and intracellular Na+ and K+ were determined before and after incubation for 1 h at 37 degrees C. The intracellular (ic) Na+ and K+ concentrations after separation of HML were 17 +/- 5 and 59 +/- 18 mmol/kg wet cells (mean +/- SD, n = 6), respectively. In the absence of aldosterone the ic Na+ concentration decreased to 12 +/- 4, whereas the ic Na+ concentration remained constant at 18 +/- 8 mmol/kg wet

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4

Wu, X., J. K. Moore, and J. E. Haber. "Mechanism of MAT alpha donor preference during mating-type switching of Saccharomyces cerevisiae." Molecular and Cellular Biology 16, no. 2 (1996): 657–68. http://dx.doi.org/10.1128/mcb.16.2.657.

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During homothallic switching of the mating-type (MAT) gene in Saccharomyces cerevisiae, a- or alpha-specific sequences are replaced by opposite mating-type sequences copied from one of two silent donor loci, HML alpha or HMRa. The two donors lie at opposite ends of chromosome III, approximately 190 and 90 kb, respectively, from MAT. MAT alpha cells preferentially recombine with HMR, while MATa cells select HML. The mechanisms of donor selection are different for the two mating types. MATa cells, deleted for the preferred HML gene, efficiently use HMR as a donor. However, in MAT alpha cells, HM

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5

Hanke, Kirsten, Philipp Kramer, Sandra Seeher, Nadine Beimforde, Reinhard Kurth, and Norbert Bannert. "Reconstitution of the Ancestral Glycoprotein of Human Endogenous Retrovirus K and Modulation of Its Functional Activity by Truncation of the Cytoplasmic Domain." Journal of Virology 83, no. 24 (2009): 12790–800. http://dx.doi.org/10.1128/jvi.01368-09.

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ABSTRACT Endogenous retroviruses present in the human genome provide a rich record of ancient infections. All presently recognized elements, including the youngest and most intact proviruses of the human endogenous retrovirus K(HML-2) [HERV-K(HML-2)] family, have suffered postinsertional mutations during their time of chromosomal residence, and genes encoding the envelope glycoprotein (Env) have not been spared these mutations. In this study, we have, for the first time, reconstituted an authentic Env of a HERV-K(HML-2) provirus by back mutation of putative postinsertional amino acid changes o

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6

Gao, Hong-Shuai, Rong-Min Hu, Ze-Hua Wang, et al. "A Polydnavirus Protein Tyrosine Phosphatase Negatively Regulates the Host Phenoloxidase Pathway." Viruses 15, no. 1 (2022): 56. http://dx.doi.org/10.3390/v15010056.

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Polydnavirus (PDV) is a parasitic factor of endoparasitic wasps and contributes greatly to overcoming the immune response of parasitized hosts. Protein tyrosine phosphatases (PTPs) regulate a wide variety of biological processes at the post-transcriptional level in mammals, but knowledge of PDV PTP action during a parasitoid–host interaction is limited. In this study, we characterized a PTP gene, CvBV_12-6, derived from Cotesia vestalis bracovirus (CvBV), and explored its possible regulatory role in the immune response of the host Plutella xylostella. Our results from qPCR show that CvBV_12-6

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7

Baskal, Svetlana, та Dimitrios Tsikas. "Free L-Lysine and Its Methyl Ester React with Glyoxal and Methylglyoxal in Phosphate Buffer (100 mM, pH 7.4) to Form Nε-Carboxymethyl-Lysine, Nε-Carboxyethyl-Lysine and Nε-Hydroxymethyl-Lysine". International Journal of Molecular Sciences 23, № 7 (2022): 3446. http://dx.doi.org/10.3390/ijms23073446.

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Glyoxal (GO) and methylglyoxal (MGO) are highly reactive species formed in carbohydrate metabolism. Nε-Carboxymethyllysine (CML) and Nε-carboxyethyllysine (CEL) are considered to be the advanced glycation end-products (AGEs) of L-lysine (Lys) with GO and MGO, respectively. Here, we investigated the reaction of free L-lysine (Lys) with GO and MGO in phosphate buffer (pH 7.4) at 37 °C and 80 °C in detail in the absence of any other chemicals which are widely used to reduce Schiff bases. The concentrations of Lys, GO and MGO used in the experiments were 0.5, 2.5, 5.0, 7.5 and 10 mM. The reaction

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8

Frank, Oliver, Caroline Verbeke, Norbert Schwarz, et al. "Variable Transcriptional Activity of Endogenous Retroviruses in Human Breast Cancer." Journal of Virology 82, no. 4 (2007): 1808–18. http://dx.doi.org/10.1128/jvi.02115-07.

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ABSTRACT Human endogenous retroviruses (HERVs) account for up to 9% of the human genome and include more than 800 elements related to betaretroviruses. While mouse mammary tumor virus (MMTV) is the accepted etiological agent of mammary tumors in mice, the role of retroviral elements in human breast cancer remains elusive. Here, we performed a comprehensive microarray-based analysis of overall retroviral transcriptional activities in 46 mammary gland tissue specimens representing pairs of nonmalignant and tumor samples from 23 patients. An analysis of nonmalignant tissue samples revealed a dist

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9

Goto, Akira, Tatsuhiko Kadowaki, and Yasuo Kitagawa. "Drosophila hemolectin gene is expressed in embryonic and larval hemocytes and its knock down causes bleeding defects11Two hml-GAL4 lines (w1118; P{w + mc = GAL4-Hml} 5-6 and w1118; P{w + mc = GAL4-Hml}6-4) and one homozygote of d-hml-GAL4, UAS-gfpnlacZ, UAS-gfp[S65T]/d-hml-GAL4, UAS-gfpnlacZ, UAS-gfp[S65T] (w1118; P{w + mc = GAL4-Hml} 6-4 P{w + mc = UAS-GFP::lacZ.nls} 15.1) transgenic lines are available from the Bloomington Stock Center with the stock numbers of 6395, 6396, and 6397, respectively." Developmental Biology 264, no. 2 (2003): 582–91. http://dx.doi.org/10.1016/j.ydbio.2003.06.001.

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10

Yin, Hong, Patrik Medstrand, Anna Kristofferson, Ursula Dietrich, Pierre Åman, and Jonas Blomberg. "Characterization of Human MMTV-like (HML) Elements Similar to a Sequence That Was Highly Expressed in a Human Breast Cancer: Further Definition of the HML-6 Group." Virology 256, no. 1 (1999): 22–35. http://dx.doi.org/10.1006/viro.1998.9587.

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11

Medstrand, P., H. Yin, D. L. Mager, J. Blomberg, and U. Dietrich. "Structure and genomic organization of a novel human endogenous retrovirus family: HERV-K (HML-6)." Journal of General Virology 78, no. 7 (1997): 1731–44. http://dx.doi.org/10.1099/0022-1317-78-7-1731.

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12

Nugroho, Andhika Puspito, Niken Satuti Nur Handayani, and I. Gede Angga Pramudita. "EFFECTS OF CHROMIUM (Cr) ON FRESHWATER MUSSEL Anodonta woodiana (Lea, 1834): DISTRIBUTION, BIOACCUMULATION, AND GENOMIC DNA DAMAGE." KnE Life Sciences 2, no. 1 (2015): 180. http://dx.doi.org/10.18502/kls.v2i1.139.

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<p>Chromium (Cr) is one of metals which are toxic to organisms at elevated concentration. In freshwater ecosystems, Cr concentration can be increased due to discharge of chromium-containing wastewater coming from leather tanning and electroplating industries. Mussels are known to accumulate metals in their body. The objectives of this research were to study distribution and bioaccumulation of Cr in the freshwater mussel Anodonta woodiana, and its effect on genomic DNA. In this research, mussels were exposed to Cr via water (25 ìg L-1) for 24 days, followed by 12 days of depuration. On da

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13

Mikhalkevich, Natallia, Ina P. O’Carroll, Rok Tkavc, et al. "Response of human macrophages to gamma radiation is mediated via expression of endogenous retroviruses." PLOS Pathogens 17, no. 2 (2021): e1009305. http://dx.doi.org/10.1371/journal.ppat.1009305.

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Ionizing radiation-induced tissue damage recruits monocytes into the exposed area where they are differentiated to macrophages. These implement phagocytic removal of dying cells and elicit an acute inflammatory response, but can also facilitate tumorigenesis due to production of anti-inflammatory cytokines. Using primary human monocyte-derived macrophages (MDMs) and the THP1 monocytic cell line, we demonstrate that gamma radiation triggers monocyte differentiation toward the macrophage phenotype with increased expression of type I interferons (IFN-I) and both pro- and anti-inflammatory macroph

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14

Weiffenbach, B., and J. E. Haber. "Homothallic switching of Saccharomyces cerevisiae mating type genes by using a donor containing a large internal deletion." Molecular and Cellular Biology 5, no. 8 (1985): 2154–58. http://dx.doi.org/10.1128/mcb.5.8.2154-2158.1985.

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Homothallic switching of the mating type genes of Saccharomyces cerevisiae occurs by a gene conversion event, replacing sequences at the expressed MAT locus with a DNA segment copied from one of two unexpressed loci, HML or HMR. The transposed Ya or Y alpha sequences are flanked by homologous regions that are believed to be essential for switching. We examined the transposition of a mating type gene (hmr alpha 1-delta 6) which contains a 150-base-pair deletion spanning the site where the HO endonuclease generates a double-stranded break in MAT that initiates the gene conversion event. Despite

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Weiffenbach, B., and J. E. Haber. "Homothallic switching of Saccharomyces cerevisiae mating type genes by using a donor containing a large internal deletion." Molecular and Cellular Biology 5, no. 8 (1985): 2154–58. http://dx.doi.org/10.1128/mcb.5.8.2154.

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Homothallic switching of the mating type genes of Saccharomyces cerevisiae occurs by a gene conversion event, replacing sequences at the expressed MAT locus with a DNA segment copied from one of two unexpressed loci, HML or HMR. The transposed Ya or Y alpha sequences are flanked by homologous regions that are believed to be essential for switching. We examined the transposition of a mating type gene (hmr alpha 1-delta 6) which contains a 150-base-pair deletion spanning the site where the HO endonuclease generates a double-stranded break in MAT that initiates the gene conversion event. Despite

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16

Zhao, Pengyu. "Covid-19's Impact on the U.S. Stock Market based on Fama-Frech Multi-factors Model." BCP Business & Management 25 (August 30, 2022): 379–86. http://dx.doi.org/10.54691/bcpbm.v25i.1847.

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Since COVID-19 outbreak in 2019 has hugely impacted the global economy, influencing the U.S. stock market. Many industries went through the shutdown, heavy loss, and bankruptcy. During this challenging period, investors suffered from tremendous stresses of financial risk and sought to use the capital asset pricing model to evaluate different stock portfolios. This article is designed to help them find an effective investment method to gain more return in the U.S. stock market. The daily 49 Industry Portfolios datasets used in this research are from Kenneth R. French Data Library and were selec

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17

Van Der Velden, Daphne Liselotte, Lisanne C. Hamming, Henk M. W. Verheul, et al. "The Drug Rediscovery Protocol (DRUP)." Journal of Clinical Oncology 35, no. 15_suppl (2017): 2547. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.2547.

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2547 Background: Bringing precision medicine to cancer patients remains a challenge. For many cancers, the relative contribution of tumor type, mutations or CNV to drug sensitivity remains unknown. In addition, drug access is generally limited to the labeled indication, bypassing rarer disease subgroups for which large trials are not feasible. An innovative trial that facilitates drug access, whilst systematically analyzing treatment outcomes and biomarkers, could help overcome these challenges. Methods: We designed a prospective, non randomized clinical trial in which patients with advanced c

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18

Candika, Yossy Imam. "TESTING THE EFFECTIVENESS OF THE CARHART MODEL FOUR FACTORS ON EXCESS RETURNS IN INDONESIA." TIJAB (The International Journal of Applied Business) 1, no. 1 (2019): 60. http://dx.doi.org/10.20473/tijab.v1.i1.2017.60-74.

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One crucial information for investor in making their investment decision is to estimate asset-pricing level. The basic principle would be high risk, high return. This research is using Carhart model (1997): market return, size, book to market, and momentum. The goal of this research is to test and analyze the influence of Carhart Four Factor Model toward Indonesian stock' excess return. Dependent variable used in this research is stock' excess return, while independent variable used are Carhart four factor model. Population used is all non-financial firms listed in Bursa Efek Indonesia from ye

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Karamitros, Timokratis, Tara Hurst, Emanuele Marchi, et al. "Human Endogenous Retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model." Proceedings of the National Academy of Sciences 115, no. 41 (2018): 10434–39. http://dx.doi.org/10.1073/pnas.1811940115.

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HERV-K HML-2 (HK2) has been proliferating in the germ line of humans at least as recently as 250,000 years ago, with some integrations that remain polymorphic in the modern human population. One of the solitary HK2 LTR polymorphic integrations lies between exons 17 and 18 of RASGRF2, a gene that affects dopaminergic activity and is thus related to addiction. Here we show that this antisense HK2 integration (namely RASGRF2-int) is found more frequently in persons who inject drugs compared with the general population. In a Greek HIV-1–positive population (n = 202), we found RASGRF2-int 2.5 times

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20

Rhodes, Christopher J. "An Electron Spin Resonance Investigation of the Radiolysis of Hexamethylbenzene and Hexamethyl(Dewar)Benzene." Progress in Reaction Kinetics and Mechanism 28, no. 1 (2003): 57–74. http://dx.doi.org/10.3184/007967403103165459.

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Exposure of hexamethyl(Dewar)benzene (HMD) to γ-rays in a solid CFC13 matrix at 77K generated the corresponding radical cation (HMD+•) as shown by the observation of hyperfine coupling (A = 9·5 G) to the protons of four equivalent methyl groups: thus the 2B2 state (I) of the ion is established. On annealing to 140 K, ring-opening occurred to give the hexamethylbenzene cation (HMB+•). When CF2ClCFCl2 was used as the matrix material, a completely different spectrum was produced, consisting of seven lines with a common spacing of 14 G. Results obtained using different batches of the freon, and fr

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Ling, Pick-Soon, and Ruzita Abdul-Rahim. "MANAGERIAL ABILITIES AND FACTOR INVESTMENT STYLE PERFORMANCES OF MALAYSIAN MUTUAL FUND MANAGERS." Journal of Nusantara Studies (JONUS) 6, no. 1 (2021): 118–35. http://dx.doi.org/10.24200/jonus.vol6iss1pp118-135.

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Background and Purpose: Studies focusing on mutual fund managerial abilities and investment style strategies are still scarce in the literature. Thus, this study aims to provide new evidence and insights into the managerial abilities and investment style performances of Malaysian fund managers.  Methodology: A total of 444 Malaysian equity mutual funds (EMFs) were evaluated using Carhart’s model incorporated with Treynor-Mazuy (T-M) and Henriksson-Merton (H-M) market timing models for the study period, from January 1995 to December 2017.  Findings: Fund managers display

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Brousse, N., A. Jarry, M. Peuchmaur, et al. "MONOCLONAL ANTIBODY (HML-1) REACTIVITY OF T-CELL LYMPHOMAS." Lancet 334, no. 8671 (1989): 1107–8. http://dx.doi.org/10.1016/s0140-6736(89)91130-6.

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23

My, Bùi Hà, Nguyễn Thị Hương, Nguyễn Hữu Đức, and Trần Thị Thúy Hà. "A study on genetic diversity of bagrid catfish (Hemibagrus guttatus Lacepede, 1803) using microsatellite markers." Vietnam Journal of Biotechnology 16, no. 1 (2018): 59–65. http://dx.doi.org/10.15625/1811-4989/16/1/9203.

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Bagrid catfish (Hemibagrus guttatus Lacepede, 1803) is a wild species of high economic value in Northern Vietnam. Artificial reproduction of bagrid catfish requires sources of quality fingerlings in terms of genetics. In fact, bagrid catfish is endangered due to overhunting. Until now, studying on bagrid catfish was mainly focused on biology characterictics and artificial breeding. In this study, three microsatellite markers were used to assess the genetic characteristics of four bagrid catfish populations (three wild populations collected in Tuyên Quang, Phu Tho, Ha Giang and a cultured popul

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24

Zhang, XG, JP Gaillard, N. Robillard, et al. "Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma." Blood 83, no. 12 (1994): 3654–63. http://dx.doi.org/10.1182/blood.v83.12.3654.bloodjournal83123654.

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We report a novel, reproducible methodology which enabled 10 human myeloma cell lines (HMCL) to be obtained from each of 10 tumor samples harvested from 9 patients with extramedullary proliferation. Fresh samples were cultured with interleukin 6 (IL-6) and granulocyte macrophage-colony stimulating factor (GM-CSF) at a high cell density and resulting HMCL growth became progressively dependent on IL-6 alone, no longer requiring GM-CSF. These HMCL, which had the same immunoglobulin gene rearrangements as the patients' original myeloma cells, were designated XG-1 to XG-9. XG HMCL had a plasma cell

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Zhang, XG, JP Gaillard, N. Robillard, et al. "Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma." Blood 83, no. 12 (1994): 3654–63. http://dx.doi.org/10.1182/blood.v83.12.3654.3654.

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Abstract We report a novel, reproducible methodology which enabled 10 human myeloma cell lines (HMCL) to be obtained from each of 10 tumor samples harvested from 9 patients with extramedullary proliferation. Fresh samples were cultured with interleukin 6 (IL-6) and granulocyte macrophage-colony stimulating factor (GM-CSF) at a high cell density and resulting HMCL growth became progressively dependent on IL-6 alone, no longer requiring GM-CSF. These HMCL, which had the same immunoglobulin gene rearrangements as the patients' original myeloma cells, were designated XG-1 to XG-9. XG HMCL had a pl

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26

Leger, H., E. Sock, K. Renner, F. Grummt, and M. Wegner. "Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y." Molecular and Cellular Biology 15, no. 7 (1995): 3738–47. http://dx.doi.org/10.1128/mcb.15.7.3738.

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The POU domain protein Tst-1/Oct-6 is a transcriptional activator of human papovavirus JC virus in transient transfections. Because of its endogenous expression in myelinating glia, Tst-1/Oct-6 might also be an important determinant for the glia specificity of JC virus in vivo. Activation of viral early and late genes depends on the ability of Tst-1/Oct-6 to interact with an AT-rich element within the viral regulatory region. Here, we show that this element not only is bound by Tst-1/Oct-6 but, in addition, serves as a binding site for the high-mobility-group protein HMG-I/Y. In the presence o

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27

Kushch, Lyudmila A., Eduard B. Yagubskii, Sergey V. Simonov, et al. "Transformation of the [MnII2MnIII2(hmp)6]4+Core into [CoIII2MnII2(hmp)6]4+in the Reaction of the [Mn4(hmp)6(NO3)2(H2O)2] Cluster with [CoX4]2-(X = Cl, Br)." European Journal of Inorganic Chemistry 2013, no. 32 (2013): 5603–11. http://dx.doi.org/10.1002/ejic.201300652.

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Liu, Y., A. Lucas-Hahn, B. Petersen, et al. "18 DEVELOPMENTAL COMPETENCE OF CLONED PORCINE EMBRYOS PRODUCED WITH DIFFERENT CLONING PROCEDURES." Reproduction, Fertility and Development 26, no. 1 (2014): 123. http://dx.doi.org/10.1071/rdv26n1ab18.

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Two nuclear transfer (NT) techniques are routinely used to produce cloned animals, traditional cloning (TC) and handmade cloning (HMC). The TC embryos keep their zona and can be transferred at early stages, whereas HMC embryos are zona-free and must be cultured to the morula/blastocyst stage before transfer. Some studies have shown that in vitro culture reduces embryo development and quality, but it is not known whether embryos produced by TC or HMC differ because of the NT method or the in vitro culture. Therefore, we investigated the developmental competence and histone acetylation (H3K18ac)

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Ruggieri, Alessia, Esther Maldener, Marlies Sauter, et al. "Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec." Retrovirology 6, no. 1 (2009): 17. http://dx.doi.org/10.1186/1742-4690-6-17.

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Slater, Gary, David Jenkins, Peter Logan та ін. "β-Hydroxy-β-Methylbutyrate (HMB) Supplementation Does Not Affect Changes in Strength or Body Composition during Resistance Training in Trained Men". International Journal of Sport Nutrition and Exercise Metabolism 11, № 3 (2001): 384–96. http://dx.doi.org/10.1123/ijsnem.11.3.384.

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This investigation evaluated the effects of oral β-Hydroxy-β-Methylbutyrate (HMB) supplementation on training responses in resistance-trained male athletes who were randomly administered HMB in standard encapsulation (SH), HMB in time release capsule (TRH), or placebo (P) in a double-blind fashion. Subjects ingested 3 g · day−1 of HMB or placebo for 6 weeks. Tests were conducted pre-supplementation and following 3 and 6 weeks of supplementation. The testing battery assessed body mass, body composition (using dual energy x-ray absorptiometry), and 3-repetition maximum isoinertial strength, plus

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Crowe, Melissa J., Donna M. O’Connor, and Joann E. Lukins. "The Effects of ß-Hydroxy-ß-Methylbutyrate (HMB) and HMB/Creatine Supplementation on Indices of Health in Highly Trained Athletes." International Journal of Sport Nutrition and Exercise Metabolism 13, no. 2 (2003): 184–97. http://dx.doi.org/10.1123/ijsnem.13.2.184.

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This study aimed to investigate the effects of 6 wk oral supplementation of ß-hydroxy- ß-methylbutyrate (HMB) and HMB combined with creatine monohy-drate (HMBCr) on indices of health in highly trained athletes. Elite, male rugby league players (n = 28) were allocated to 1 of 3 groups: a control group (n = 6), a HMB group (3 g/d; n = 11), or a HMBCr group (3 g/day HMB, 3 g/d Cr; n = 11). Testing prior to, and immediately following, supplementation included a full blood count, plasma testosterone and cortisol, blood electrolytes, lipids, urea and glucose, sperm count and motility, and assessment

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Ratti, Stefano, Matteo Zarantoniello, Giulia Chemello, et al. "Spirulina-enriched Substrate to Rear Black Soldier Fly (Hermetia illucens) Prepupae as Alternative Aquafeed Ingredient for Rainbow Trout (Oncorhynchus mykiss) Diets: Possible Effects on Zootechnical Performances, Gut and Liver Health Status, and Fillet Quality." Animals 13, no. 1 (2023): 173. http://dx.doi.org/10.3390/ani13010173.

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In the present study, an organic substrate (coffee silverskin) enriched with spirulina (Arthrospira platensis; 15% w/w), as a source of lipids and bioactive molecules, was used to rear the black soldier fly (Hermetia illucens) prepupae. Three grossly isonitrogenous, isoproteic, isolipidic and isoenergetic experimental diets for rainbow trout (Oncorhynchus mykiss) juveniles were then produced: a control diet (HM0) mostly including fish meal and fish oil, and two other test diets named HM3 and HM20, in which 3 or 20% of the marine ingredients were substituted with full fat black soldier fly prep

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Chi, David, Fangbai Wu, Ta-Chang Lin, Kenton Hall, Zong Wu, and Guha Krishnaswamy. "Baicalein inhibits the enhancing effects of cigarette smoke extract (CSE) on inflammatory cytokine production in IL-1beta activated mast cells (35.5)." Journal of Immunology 184, no. 1_Supplement (2010): 35.5. http://dx.doi.org/10.4049/jimmunol.184.supp.35.5.

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Abstract Human mast cells play a role in the pathogenesis of inflammatory airway diseases. We have reported that CSE increased IL-6 and IL-8 production in IL-1beta activated human mast cells (HMC-1). Baicalein (BAI) has been shown to have anti-inflammatory properties. This study aimed to examine the effect of BAI on IL-6 and IL-8 production in HMC-1. Two ml of HMC-1 at 1 x 106 cells/ml were cultured either with or without IL-1beta (10 ng/ml), and in the presence or absence of mainstream (Ms) or sidestream (Ss) CSE (0.25 mg/ml or 0.125 mg/ml), and BAI (30 μM). Treated HMC-1 were incubated for 2

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Zhang, X. G., J. J. Gu, Z. Y. Lu, et al. "Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130." Journal of Experimental Medicine 179, no. 4 (1994): 1337–42. http://dx.doi.org/10.1084/jem.179.4.1337.

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Interleukin 6 (IL-6) is a major growth factor for tumor plasma cells involved in human multiple myeloma (MM). In particular, human myeloma cell lines (HMCL), whose growth is completely dependent on addition of exogenous IL-6, can be obtained reproducibly from every patient with terminal disease. Four cytokines, ciliary neurotropic factor (CNTF), IL-11, leukemia inhibitory factor (LIF), and oncostatin M (OM), use the same transducer chain (signal transducer gp130) as IL-6 and share numerous biological activities with this IL. We found that these four cytokines stimulated proliferation and suppo

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Liu, Y., A. Lucas-Hahn, B. Petersen, et al. "15 HISTONE ACETYLATION PROFILE OF PORCINE EMBRYOS PRODUCED BY 2 CLONING METHODS WITH OR WITHOUT IN VITRO CULTURE." Reproduction, Fertility and Development 28, no. 2 (2016): 137. http://dx.doi.org/10.1071/rdv28n2ab15.

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Conventional “Dolly”-based cloned (CNT) embryos maintain zona pellucida and can be transferred early in development. Handmade cloned (HMC) embryos are zona free and are cultured to later stages for transfer. We have shown differences between HMC and CNT embryos (Rep. Fert. Dev. 26, 123), and both in vitro culture and cloning method (NT) are associated with alterations in histone acetylation. More studies are needed to clarify whether CNT and HMC embryos differ in epigenetic profiles due to NT method or culture condition. Here we investigated histone acetylation profile of NT embryos produced b

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Qin, Ye-Zhi, Yan-Mei Li, Min-Hua Zong, Hong Wu, and Ning Li. "Enzyme-catalyzed selective oxidation of 5-hydroxymethylfurfural (HMF) and separation of HMF and 2,5-diformylfuran using deep eutectic solvents." Green Chemistry 17, no. 7 (2015): 3718–22. http://dx.doi.org/10.1039/c5gc00788g.

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Umaretiya, Puja J., Victoria B. Koch, Kristen E. Stevenson, et al. "Household material hardship and parental distress in a multicenter clinical trial for pediatric acute lymphoblastic leukemia." Journal of Clinical Oncology 39, no. 15_suppl (2021): 10025. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.10025.

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10025 Background: Poverty is associated with inferior psychosocial function among parents of children with cancer. Severe parental distress during treatment predicts future poor mental health for both parents and children. It is also associated with impaired parental cognitive bandwidth and executive function, which may have implications for treatment adherence. Efforts to identify poverty-exposures amenable to intervention are essential to improving survivorship quality of life for the > 90% of children with acute lymphoblastic leukemia (ALL) who will be long-term survivors. Household mate

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Ann S. Arndt, Mary, та William D. Wheaton. "Critical role of high-mobility-group proteins in kidney development/cross-talk Wnt/β-catenin signaling pathway". American Journal of BioMedicine 9, № 1 (2021): 123–34. http://dx.doi.org/10.18081/2333-5106/021-01/123-134.

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The treatment of severe acute kidney injury with dialytic support for renal replacement therapy can be life sustaining and permit recovery from critical illness. The high-mobility-group (HMG) proteins are the most abundant non-histone chromatin-associated proteins. HMG proteins are present at high levels in various undifferentiated tissues during embryonic development and reduced in the corresponding adult tissues. We used used in study C57BL/6, HMG+/− and HMG−/− mice and found that HMG is expressed in the mouse embryonic kidney at the cortex area. HMG knockout led to enhanced Wnt/β-catenin si

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Malcher, Stella Miranda, Julio Cesar Pieczarka, Lena Geise, et al. "Genômica comparativa entre Cerradomys scotti e Cerradomys subflavus por pintura cromossômica." Semina: Ciências Biológicas e da Saúde 38, no. 1supl (2018): 181. http://dx.doi.org/10.5433/1679-0367.2017v38n1suplp181.

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O gênero Cerradomys apresenta atualmente 8 espécies, todas com cariótipos básicos descritos. Essas espécies apresentam grande variação cromossômica, com número diploide variando de 2n=46 em Cerradomys langguthi a 2n=60 em C. akroai. Neste trabalho estudamos comparativamente os cariótipos de Cerradomys scotti (CSC) e Cerradomys subflavus (CSU) por bandeamntos G, C e pintura cromossômica utilizando sondas cromossomos totais de Hylaeamys megacephalus (HME: 2n=54, NFa=62). Analisamos 3 exemplares de C. scotti (1 macho e 2 fêmeas) coletados nos estados de Mato Grosso e Minas Gerais e 3 exemplares d

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Hsieh, Chia-Jung, Kenton Hall, Guha Krishnaswamy та David S. Chi. "Differential effects of berberine, baicalein, and triptolide on cytokine production from IL-1β-activated mast cells (95.28)". Journal of Immunology 178, № 1_Supplement (2007): S182. http://dx.doi.org/10.4049/jimmunol.178.supp.95.28.

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Abstract Human mast cells are multifunctional cells capable of a wide variety of inflammatory responses. Berberine (BER), baicalein (BAI), and triptolide (TRI) are compounds isolated from traditional Chinese medicinal herbs and have been shown to have anti-inflammatory effects. We examined their effects on the production of inflammatory cytokines from IL-1β-activated human mast cells (HMC-1). Two ml of HMC-1 at 1 x 106 cells / mL were cultured with BER, BAI, and TRI (at predetermined non-toxic concentrations) in the presence or absence of IL-1β (10 ng / mL) for 24 hrs. The supernatants were ha

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Dao, Elizabeth, Cindy K. Barha, John R. Best, Ging-Yuek Hsiung, Roger Tam, and Teresa Liu-Ambrose. "The Effect of Aerobic Exercise on White Matter Hyperintensity Progression May Vary by Sex." Canadian Journal on Aging / La Revue canadienne du vieillissement 38, no. 02 (2019): 236–44. http://dx.doi.org/10.1017/s0714980818000582.

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RÉSUMÉCette étude a exploré l’efficacité de l’entraînement aérobie (EA) pour atténuer la progression de l’hyperintensité de la matière blanche (HMB) et les différences liées au sexe pour cette intervention. Un essai contrôlé randomisé a été mené pour évaluer l’effet de l’EA sur la cognition de personnes ayant un déficit cognitif d’origine vasculaire. Les participants ont été répartis aléatoirement entre deux groupes : 6 mois d’EA ou soins standards (groupe contrôle). Dans un sous-groupe de participants, l’imagerie par résonance magnétique a été utilisée pour quantifier le volume affecté par la

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Romagnoli, Mathilde, Regis Bataille, and Sophie Barillé-Nion. "The Critical Role of Survivin in the Survival and Proliferation of Human Myeloma Cells." Blood 106, no. 11 (2005): 110. http://dx.doi.org/10.1182/blood.v106.11.110.110.

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Abstract Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells with an enhanced proliferation and survival capacity within the bone marrow. Myeloma cells often develop drug resistance leading to treatment failure in the patients. Survivin is a member of the inhibitors of apoptosis (IAP) gene family that has been implicated in both cell viability and cell cycle regulation and described as overexpressed in most cancers. We have observed that survivin is expressed in human myeloma cell lines (HMCL) from moderate level in both HMCL XG-6 and MM1S to strong level in U2

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Hułas-Stasiak, Monika, Joanna Jakubowicz-Gil, Piotr Dobrowolski та ін. "Regulation of Folliculogenesis by Growth Factors in Piglet Ovary Exposed Prenatally to β-Hydroxy-β-Methylbutyrate (HMB)". Annals of Animal Science 20, № 3 (2020): 899–917. http://dx.doi.org/10.2478/aoas-2020-0026.

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AbstractΒ-hydroxy-β-methylbutyrate (HMB) is one of the leucine metabolites with protein anabolic effects which makes it very popular among athletes. Previously, it was shown that HMB administered during the prenatal period reduced the pool of primordial follicles and increased the proportion of developing follicles in newborn piglets. This work is a further step to understand these morphological alterations. Therefore, the aim of this study was to examine the effect of prenatal HMB treatment on the expression of the Kit ligand, BMP-4, bFGF, and the IGF-1/IGF-1R system which are the main growth

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George, Binsah, Elias Jabbour, Monica Cabrero, et al. "Retrospective Analysis of Survival in Patients with Acute Erythroid Leukemia (AML-6) Treated with Conventional Chemotherapy Versus Hypomethylating Agents." Blood 124, no. 21 (2014): 2278. http://dx.doi.org/10.1182/blood.v124.21.2278.2278.

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Abstract Background: AML-M6 is a subtype of acute myeloid leukemia associated with poor prognosis. Hypomethylating agents (HMA) have not been extensively studied in patients with AML-6. Objective: To compare HMA therapy to conventional chemotherapy (CT) in patients with AML-6 Method: We reviewed 160 consecutive patients with AML-M6 treated with HMA (n=25) or CT (n=135) between 1980 and 2014. Patient clinical and demographic data were analyzed for contribution to survival and response outcomes. Results: The median patient age for our patients was 62 years (ranges, 16-87 years). Median follow-up

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Walia, Damandeep S., Mukut Sharma, Vineesh V. Raveendran, et al. "Human Mast Cells (HMC-1 5C6) Enhance Interleukin-6 Production by Quiescent and Lipopolysaccharide-Stimulated Human Coronary Artery Endothelial Cells." Mediators of Inflammation 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/274347.

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We examined the effect of intact human mast cells (HMC-1 5C6) and their selected mediators on interleukin-6 (IL-6) production and bone morphogenetic protein-2 (BMP-2) expression in human coronary artery endothelial cells (HCAEC) in the presence and absence of lipopolysaccharide (LPS). Scanning electron microscopy showed that HMC-1 5C6 cells adhere to HCAEC in cocultures. Addition of HMC-1 5C6 cells markedly enhanced the IL-6 production by quiescent and LPS-activated HCAEC even at the maximal concentration of LPS. Furthermore, mast cell-derived histamine and proteases accounted for the direct a

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Schneeweiss, Mathias A., Gabriele Stefanzl, Daniela Berger, et al. "The CDK4/6 Inhibitor Palbociclib Exerts Growth-Inhibitory Effects on Neoplastic Mast Cells and Synergizes with Midostaurin in Producing Growth Arrest." Blood 132, Supplement 1 (2018): 1363. http://dx.doi.org/10.1182/blood-2018-99-116525.

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Abstract Aggressive systemic mastocytosis (ASM) and mast cell leukemia (MCL) are rare, malignant diseases with an unfavorable prognosis. In a majority of patients, the transforming KIT mutation D816V is detectable. Currently, several drugs are available for the treatment of ASM/MCL, including midostaurin, a KIT D816V-targeting drug that has recently been approved for the treatment of advanced SM in the US and in Europe. However, when applied as single drug, midostaurin usually fails to induce durable remissions in patients with ASM/MCL, and the same holds true for all other drugs tested in the

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Rampino, Teresa, Chiara Collesi, Marilena Gregorini, et al. "Macrophage-Stimulating Protein Is Produced by Tubular Cells and Activates Mesangial Cells." Journal of the American Society of Nephrology 13, no. 3 (2002): 649–57. http://dx.doi.org/10.1681/asn.v133649.

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ABSTRACT. Until now, hepatocytes have been the only known cell source of macrophage-stimulating protein (MSP), and tissue macrophages have been the cells on which the biologic effects of MSP have been proved. To extend the understanding of the biologic meaning of MSP, it was investigated whether MSP operates in the kidney. MSP protein was evaluated by Western blot in supernatant of cultured human tubular cells (HK2) and human mesangial cells (HMC). MSP mRNA was investigated in HK2 by reverse transcription–polymerase chain reaction (RT-PCR). The expression of the MSP receptor, RON, was evaluate

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Rathmacher, John A., Lisa M. Pitchford, Paul Khoo та ін. "Long-term Effects of Calcium β-Hydroxy-β-Methylbutyrate and Vitamin D3 Supplementation on Muscular Function in Older Adults With and Without Resistance Training: A Randomized, Double-blind, Controlled Study". Journals of Gerontology: Series A 75, № 11 (2020): 2089–97. http://dx.doi.org/10.1093/gerona/glaa218.

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Abstract The primary aim of this study was to determine whether supplementation with calcium β-hydroxy-β-methylbutyrate (HMB) and vitamin D3 (D) would enhance muscle function and strength in older adults. Older adults over 60 years of age with insufficient circulating 25-hydroxy-vitamin D (25OH-D) levels were enrolled in a double-blinded controlled 12-month study. Study participants were randomly assigned to treatments consisting of: (a) Control + no exercise, (b) HMB+D + no exercise, (c) Control + exercise, and (d) HMB+D + exercise. The study evaluated 117 participants via multiple measuremen

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Nissen, S., R. Sharp, M. Ray та ін. "Effect of leucine metabolite β-hydroxy-β-methylbutyrate on muscle metabolism during resistance-exercise training". Journal of Applied Physiology 81, № 5 (1996): 2095–104. http://dx.doi.org/10.1152/jappl.1996.81.5.2095.

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Nissen, S., R. Sharp, M. Ray, J. A. Rathmacher, D. Rice, J. C. Fuller, Jr., A. S. Connelly, and N. Abumrad. Effect of leucine metabolite β-hydroxy-β-methylbutyrate on muscle metabolism during resistance-exercise training. J. Appl. Physiol. 81(5): 2095–2104, 1996.—The effects of dietary supplementation with the leucine metabolite β-hydroxy-β-methylbutyrate (HMB) were studied in two experiments. In study 1, subjects ( n = 41) were randomized among three levels of HMB supplementation (0, 1.5 or 3.0 g HMB/day) and two protein levels (normal, 117 g/day, or high, 175 g/day) and weight lifted for 1.5

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Sjostrand, Rebecca, Braden Troyer, Levi J. McPhillips, et al. "196 Interaction of Corn Processing Method and Sweet Bran Inclusion in Finishing Diets." Journal of Animal Science 100, Supplement_2 (2022): 94–95. http://dx.doi.org/10.1093/jas/skac064.156.

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Abstract Two studies were conducted to evaluate the effect of corn processing method and wet corn gluten feed [Sweet Bran (SB); Cargill] concentration on feedlot performance and nutrient digestion. Treatments were arranged as a 2 × 3 factorial, consisting of two corn processing methods [steam-flaked corn (SFC) or a high-moisture corn (HMC) dry-rolled corn (DRC) blend] and 3 inclusions of SB (0, 20, or 40% of diet dry matter). In Exp. 1, yearling steers (n = 480; initial body weight = 363 ± 15.1 kg) were utilized in a randomized block design. A linear interaction was observed for average daily

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