Relevant bibliographies by topics / HMW

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'HMW'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 February 2022

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Journal articles on the topic "HMW"

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Ambrus, J. L., C. H. Jurgensen, E. J. Brown, and A. S. Fauci. "Purification to homogeneity of a high molecular weight human B cell growth factor; demonstration of specific binding to activated B cells; and development of a monoclonal antibody to the factor." Journal of Experimental Medicine 162, no. 4 (October 1, 1985): 1319–35. http://dx.doi.org/10.1084/jem.162.4.1319.

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High molecular weight B cell growth factor (HMW-BCGF) produced by a T cell line was purified to homogeneity and demonstrated to bind specifically to activated human B cells. A monoclonal antibody to HMW-BCGF was developed that (a) specifically inhibited the activity of HMW-BCGF in enhancing B cell proliferation, (b) specifically bound to HMW-BCGF in Western blots, (c) specifically absorbed HMW-BCGF activity from culture supernatants, and (d) specifically absorbed an internally labeled protein from T-ALL supernatant which comigrates with HMW-BCGF on sodium dodecyl sulfate-polyacrylamide gels. This antibody should help in cloning the gene for HMW-BCGF and further exploring the physiologic roles of HMW-BCGF.
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Soulavie, Fabien, David Piepenbrock, Joëlle Thomas, Jennifer Vieillard, Jean-Luc Duteyrat, Elisabeth Cortier, Anne Laurençon, Martin C. Göpfert, and Bénédicte Durand. "hemingway is required for sperm flagella assembly and ciliary motility in Drosophila." Molecular Biology of the Cell 25, no. 8 (April 15, 2014): 1276–86. http://dx.doi.org/10.1091/mbc.e13-10-0616.

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Cilia play major functions in physiology and development, and ciliary dysfunctions are responsible for several diseases in humans called ciliopathies. Cilia motility is required for cell and fluid propulsion in organisms. In humans, cilia motility deficiencies lead to primary ciliary dyskinesia, with upper-airways recurrent infections, left–right asymmetry perturbations, and fertility defects. In Drosophila, we identified hemingway (hmw) as a novel component required for motile cilia function. hmw encodes a 604–amino acid protein characterized by a highly conserved coiled-coil domain also found in the human orthologue, KIAA1430. We show that HMW is conserved in species with motile cilia and that, in Drosophila, hmw is expressed in ciliated sensory neurons and spermatozoa. We created hmw-knockout flies and found that they are hearing impaired and male sterile. hmw is implicated in the motility of ciliated auditory sensory neurons and, in the testis, is required for elongation and maintenance of sperm flagella. Because HMW is absent from mature flagella, we propose that HMW is not a structural component of the motile axoneme but is required for proper acquisition of motile properties. This identifies HMW as a novel, evolutionarily conserved component necessary for motile cilium function and flagella assembly.
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Deng, Zhiying, Jichun Tian, and Ruibo Hu. "The accumulation of high molecular weight glutenin subunits (HMW-GS) and their relation to dough rheological quality in Chinese winter wheat." Australian Journal of Agricultural Research 57, no. 1 (2006): 41. http://dx.doi.org/10.1071/ar05080.

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Six winter wheat cultivars were categorised into high gluten, medium gluten, and low gluten according to their protein content and gluten index. The object of this study was to determine the accumulation of high molecular weight glutenin subunits (HMW-GS) and their relationship to dough rheological quality. They were grown in 3 replicates on experimental plots at the Shandong Agricultural University research farm in 2001. HMW-GS compositions during grain development were investigated by SDS-PAGE procedures, followed by imaging densitometry to determine quantitative variations. Initial formation time of HMW-GS was different among cultivars. HMW-GS in cultivars with high gluten had formed completely by 10 days after anthesis, but were still only partially formed at this time in cultivars having weak gluten. Accumulation quantities of HMW-GS followed with grain development. Individual HMW-GS accumulated rapidly between 25 days after anthesis and maturity. The kinetic accumulation trend for the individual HMW-GS was similar in the same type of cultivars, but quantities were different. Strong cultivars had more kinetic accumulation quantities of HMW-GS than weak cultivars. HMW-GS kinetic accumulation quantities during grain development were significantly positively correlated with dough rheological characteristics and SDS-sedimentation volume.
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Kellermair, Joerg, Sahrai Saeed, Helmut W. Ott, Juergen Kammler, Hermann Blessberger, Markus Suppan, Michael Grund, et al. "High-molecular-weight von Willebrand Factor multimer ratio differentiates true-severe from pseudo-severe classical low-flow, low-gradient aortic stenosis." European Heart Journal - Cardiovascular Imaging 21, no. 10 (May 17, 2020): 1123–30. http://dx.doi.org/10.1093/ehjci/jeaa056.

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Abstract Aims Upon high wall shear stress, high-molecular-weight (HMW) von Willebrand Factor (VWF) multimers are degraded, thus, HMW VWF multimer deficiency mirrors haemodynamics at the site of aortic stenosis (AS). The aim of the present study was to analyse the role of HMW VWF multimer ratio for subcategorization of classical low-flow, low-gradient (LF/LG) AS. Methods and results Eighty-three patients with classical LF/LG AS were prospectively recruited and HMW VWF multimer pattern was analysed using a densitometric quantification of western blot bands. Patients were subclassified into true-severe (TS) and pseudo-severe (PS) classical LF/LG AS based on dobutamine stress echocardiography (DSE). Positive and negative predictive values (PPV/NPV) of HMW VWF multimer ratio for diagnosis of the TS subtype were calculated. HMW VWF multimer ratio in TS classical LF/LG AS was significantly decreased compared to PS classical LF/LG AS (0.86 ± 0.27 vs. 1.06 ± 0.09, P < 0.001). HMW VWF multimer deficiency occurred exclusively in the TS subtype with an optimal PPV of 1.000 and NPV of 0.379. HMW VWF multimer ratio showed a strong correlation with mean transvalvular pressure gradients during DSE (r = −0.616; P < 0.001). HMW VWF multimer ratio measured at baseline was higher compared to levels measured after DSE (0.87 ± 0.27 vs. 0.84 ± 0.31; P = 0.031) indicating DSE-induced increased proteolysis. Conclusion HMW VWF multimer ratio represents a valuable biomarker for classical LF/LG AS subclassification and mirrors haemodynamics during DSE. HMW VWF multimer ratio identifies the TS subtype without the use of other imaging techniques.
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Li, Yi, Jiahui Fu, Qun Shen, and Dong Yang. "High-Molecular-Weight Glutenin Subunits: Genetics, Structures, and Relation to End Use Qualities." International Journal of Molecular Sciences 22, no. 1 (December 26, 2020): 184. http://dx.doi.org/10.3390/ijms22010184.

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High-molecular-weight glutenin subunits (HMW-GSs) are storage proteins present in the starchy endosperm cells of wheat grain. Encoding the synthesis of HMW-GS, the Glu-1 loci located on the long arms of group 1 chromosomes of the hexaploid wheat (1A, 1B, and 1D) present multiple allelism. In hexaploid wheat cultivars, almost all of them express 3 to 5 HMW-GSs and the 1Ay gene is always silent. Though HMW-GSs are the minor components in gluten, they are crucial for dough properties, and certain HMW-GSs make more positive contributions than others. The HMW-GS acts as a “chain extender” and provides a disulfide-bonded backbone in gluten network. Hydrogen bonds mediated by glutamine side chains are also crucial for stabilizing the gluten structure. In most cases, HMW-GSs with additional or less cysteines are related to the formation of relatively more or less interchain disulfide bonds and HMW-GSs also affect the gluten secondary structures, which in turn impact the end use qualities of dough.
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Ueshima, S., K. Silence, D. Collen, and H. R. Lijnen. "Molecular Conversions of Recombinant Staphylokinase During Plasminogen Activation in Purified Systems and in Human Plasma." Thrombosis and Haemostasis 70, no. 03 (1993): 495–99. http://dx.doi.org/10.1055/s-0038-1649612.

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SummaryRecombinant staphylokinase (STAR) is produced as a 136 amino acid protein with NH2-terminal sequence Ser-Ser-Ser (mature STAR, HMW-STAR), which may be converted to lower molecular weight forms (LMW-STAR) by removal of the first six residues (yielding STAR-Δ6 with NH2-terminal Gly-Lys-Tyr-) or the first ten residues (yielding STAR-Δ10 with NH2-terminal Lys-Gly-Asp-). In the present study the occurrence and effects of these conversions during plasminogen activation by HMW-STAR were studied in purified systems and in human plasma.In stoichiometric mixtures of HMW-STAR and native human plasminogen (Glu-plasminogen), rapid and quantitative conversion of HMW-STAR to LMW-STAR occurred, concomitant with exposure of the active site in the plasmin-STAR complex. NH2-terminal amino acid sequence analysis revealed the sequence Lys-Gly-Asp- in addition to the known sequences of the Lys-plasmin chains, identifying STAR-Δ10 as the derivative generated from HMW-STAR. In mixtures of catalytic amount of HMW-STAR and human plasminogen, plasmin generation occurred progressively, following an initial lag phase, during which HMW-STAR was converted to LMW-STAR. Plasmin-mediated conversion of HMW-STAR to LMW-STAR obeyed Michaelis-Menten kinetics with K m = 3.6 μM and k 2 = 0.38 s−1. The specific clot lysis activities of HMW-STAR (122,000 ± 8,000 units/mg) and LMW-STAR (129,000 ± 8,000 units/mg) were indistinguishable.In an in vitro system consisting of a 60 μl plasma clot submerged in 250 μl plasma, 80% clot lysis within 1 h was obtained with 70 nM HMW-STAR. This was associated with fibrinogen depletion and conversion of 20% of the HMW-STAR to LMW-STAR. Addition of 100 nM HMW-STAR to human plasma in the absence of a clot did not induce significant fibrinogen breakdown (≥ 90% residual fibrinogen after 2 h), and was not associated with significant coversion to LMW-STAR (≤10% within 2 h). With 400 nM HMW-STAR, fibrinogen depletion in plasma occurred within 1 h, and 80% conversion to LMW-STAR was observed. Thus, at fibrinolytically active concentrations which do not cause fibrinogen breakdown, no significant conversion of HMW-STAR to LMW-STAR occurs in human plasma in the absence of a clot.These findings indicate that the conversion of HMW-STAR to LMW-STAR may occur in association with clot lysis, but is not required to induce it.
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Eglit, Triin, Margus Lember, Inge Ringmets, and Tarvo Rajasalu. "Gender differences in serum high-molecular-weight adiponectin levels in metabolic syndrome." European Journal of Endocrinology 168, no. 3 (March 2013): 385–91. http://dx.doi.org/10.1530/eje-12-0688.

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ObjectiveThe objective of this study was to estimate gender-specific associations between metabolic syndrome (MS) and high-molecular-weight (HMW) adiponectin in an Estonian adult population.MethodsPlasma HMW adiponectin was measured in 458 subjects (191 men) who participated in a population-based cross-sectional multicenter study (n=495) on the prevalence of metabolic disorders in Estonia. MS was defined according to National Cholesterol Education Program Adult Treatment Panel III criteria.ResultsMedian HMW adiponectin levels (μg/ml) were significantly lower among all subjects with MS compared with subjects without MS: 2.1 vs 2.8 in men (P=0.002) and 3.1 vs 5.1 in women (P<0.001). In a fully adjusted, logistic regression model containing HMW adiponectin, homeostasis model assessment of insulin resistance (HOMA-IR), BMI, and age, HMW adiponectin was significantly associated with MS only in women. Comparison of HMW adiponectin and HOMA-IR as markers for MS indicated that HOMA-IR predicted MS better than did HMW adiponectin in both genders. However, after adjusting for age and BMI, HOMA-IR was a significantly better predictor only in men. HMW adiponectin and HOMA-IR predicted the presence of MS at the same level in women. Areas under the receiver operating characteristic curves for HMW adiponectin and HOMA-IR were 0.833 vs 0.88 in men (P=0.02) and 0.897 vs 0.907 in women (P=0.5).ConclusionsThese data suggest that the association between low HMW adiponectin levels and presence of MS might be stronger in women compared with men.
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Sinha, Madhur K., Traci Songer, Qiang Xiao, John H. Sloan, Jin Wang, Shaoquen Ji, William E. Alborn, et al. "Analytical Validation and Biological Evaluation of a High–Molecular-Weight Adiponectin ELISA." Clinical Chemistry 53, no. 12 (December 1, 2007): 2144–51. http://dx.doi.org/10.1373/clinchem.2007.090670.

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Abstract Background: Of the 3 circulating multimeric forms of adiponectin, the high–molecular-weight (HMW) form, as measured by size-exclusion and/or immunoblotting techniques, is a better index of insulin sensitivity for monitoring health and disease than is total adiponectin. We aimed to develop a simple ELISA to measure HMW adiponectin. Methods: We pretreated serum or plasma samples with digestion solution containing proteinase K (Millipore, ESDS). HMW (Millipore, EZHMWA-64K) and total adiponectin (Millipore, EZHADP-61K) concentrations were measured in treated and untreated samples, respectively, from 108 individuals and from 20 morbidly obese patients before and at 1, 3, 6, and 12 months after gastric-bypass surgery. Results: The ELISA has a dynamic range of 3–200 μg/L and a detection limit of 0.8 μg/L. Intraassay and interassay CVs were &lt;4% and &lt;10%, respectively. Sample-dilution curves paralleled the calibration curves. Fast protein liquid chromatography profiles of the proteinase K-treated samples revealed predominantly HMW adiponectin. Values for HMW adiponectin produced with this method are comparable with those obtained with Western blot analysis (y = 0.77x − 0.15; r = 0.96; n = 56). Body mass index (BMI)- and sex-related changes were more pronounced for HMW adiponectin and percentage of HMW adiponectin than for total adiponectin. HMW and total adiponectin increased after bypass surgery, but changes in HMW adiponectin were more pronounced and preceded changes in total adiponectin. Conclusion: This simple, rapid ELISA for HMW adiponectin recognizes the HMW isoform, produces results closely correlated with those obtained with Western blotting, and appears to better distinguish BMI-, sex-, and weight loss–associated differences than assays for total adiponectin.
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Lämmle, Bernhard, Bruce L. Zuraw, Mary Jo Heeb, Hans Peter Schwarz, Mauro Berrettini, John G. Curd, and John H. Griffin. "Detection and Quantitation of Cleaved and Uncleaved High Molecular Weight Kininogen in Plasma by Ligand Blotting with Radiolabeled Plasma Prekallikrein or Factor XI." Thrombosis and Haemostasis 59, no. 02 (1988): 151–61. http://dx.doi.org/10.1055/s-0038-1642745.

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SummaryA method for the quantitative assay of native single chain and kallikrein cleaved two-chain high molecular weight (HMW)-kininogen in plasma is described. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of whole plasma is followed by electrotransfer of the electropherogram to nitrocellulose membranes and detection of the blotted HMW-kininogen with its physiologic ligands, radiolabeled plasma prekallikrein or radiolabeled factor XI. Using unreduced SDS-PAGE cleaved two-chain HMW-kininogen (Mr ∼107,000 and 95,000), is elec-trophoretically separated from uncleaved single chain HMW-kininogen (Mr ∼150,000). Counting the radioactivity of the nitrocellulose pieces corresponding to cleaved HMW-kininogen permits its quantitative measurement by comparison with standards consisting of decreasing amounts of fully dextran sulfate activated normal human plasma. Single chain HMW-kininogen is similarly assayed using reduced SDS-PAGE and unactivated normal human plasma standards.This technique is highly specific and sensitive to about 50 ng of either cleaved or uncleaved HMW-kininogen. Varying amounts of cleaved HMW-kininogen were found in a small series of plasmas from patients suffering from various inflammatory conditions. Higher levels of in vivo cleaved HMW-kininogen were observed during acute attacks of hereditary angioedema due to Cl-inhibitor deficiency. This technique may be useful for the assessment of the degree of in vitro or in vivo activation of the contact system.
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van Schilfgaarde, Muriel, Peter van Ulsen, Paul Eijk, Michiel Brand, Martin Stam, Jamal Kouame, Loek van Alphen, and Jacob Dankert. "Characterization of Adherence of NontypeableHaemophilus influenzae to Human Epithelial Cells." Infection and Immunity 68, no. 8 (August 1, 2000): 4658–65. http://dx.doi.org/10.1128/iai.68.8.4658-4665.2000.

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ABSTRACT The adherence of 58 nontypeable Haemophilus influenzaeisolates obtained from patients with otitis media or chronic obstructive pulmonary disease (COPD) and obtained from the throats of healthy individuals to Chang and NCI-H292 epithelial cells was compared. Otitis media isolates, but not COPD isolates, adhered significantly more to both cell lines than did throat isolates. Since high-molecular-weight (HMW) proteins are major adhesins of nontypeableH. influenzae, the isolates were screened for HMW protein expression by Western blotting with two polyclonal sera and PCR withhmw-specific primers. Twenty-three of the 32 adhering isolates (72%) and only 1 of the 26 nonadherent strains were HMW protein or hmw gene positive. Among the 32 isolates adhering to either cell line, 5 different adherence patterns were distinguished based on the inhibiting effect of dextran sulfate. UsingH. influenzae strain 12 expressing two well-defined HMW proteins (HMW1 and HMW2) and its isogenic mutants as a reference, we observed HMW1-like adherence to both cell lines for 16 of the 32 adherent isolates. Four others showed HMW2-like adherence to NCI-H292. Of the three other patterns of adherence, one probably also involved HMW protein. Screening of the isolates with six HMW-specific monoclonal antibodies in a whole-cell enzyme-linked immunosorbent assay showed that the HMW proteins of COPD isolates and carrier isolates were more distinct from the HMW proteins from H. influenzae strain 12 than those from otitis media isolates. Characterization of the HMW protein of a COPD isolate by adherence and DNA sequence analysis showed that despite large sequence diversity in the hmwA gene, probably resulting in the antigenic differences, the HMW protein mediated the HMW2-like adherence of this strain.
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Dissertations / Theses on the topic "HMW"

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Alrawi, Sura, and Manar Younan. "High Molecular Weight (HMW) snabbtypning av Clostridium difficile med MALDI-TOF MS : Genom två metoder direkt och proteinextraktion." Thesis, Hälsohögskolan, Högskolan i Jönköping, HHJ. Biomedicinsk plattform, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-31515.

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Aluwihare, Lihini Indira. "High molecular weight (HMW) dissolved organic matter (DOM) in seawater : chemical structure, dources and cycling." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/53038.

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Thesis (Ph. D.)--Joint Program in Chemical Oceanography (Massachusetts Institute of Technology, Dept. of Earth, Atmospheric and Planetary Sciences; and the Woods Hole Oceanographic Institution), 1999.
Includes bibliographical references.
The goal of this thesis was to use high resolution analytical techniques coupled with molecular level analyses to chemically characterize high molecular weight (> 1 k Da (HMW)) dissolved organic matter (DOM) isolated from seawater in an attempt to provide new insights in to the cycling of DOM in the ocean. While a variety of sites spanning different environments (fluvial, coastal and oceanic) and ocean basins were examined, the chemical structure of the isolated HMW DOM varied little at both the polymer and monomer levels. All samples show similar ratios of carbohydrate:acetate:lipid carbon (80±4:10±2:9±4) indicating that these biochemicals are present within a family of related polymers. The carbohydrate fraction shows a characteristic distribution of seven major neutral monosaccharides: rhamnose, fucose, arabinose, xylose, mannose, glucose and galactose; and additionally contains Nacetylated amino sugars as seen by Nuclear Magnetic Resonance Spectroscopy (NMR). This family of compounds, consisting of a specifically linked polysaccharide backbone that is acylated at several positions, has been termed acylated polysaccharides (APS) by our laboratory. APS accounts for 50% of the carbon in HMW DOM isolated from the surface ocean and 20% of the carbon in HMW DOM isolated from the deep ocean. In order to identify a possible source for APS three species of phytoplankton, Thalassiossira weissflogii, Emiliania huxleyi and Phaeocystis, were cultured in seawater and their HMW DOM exudates examined by variety of analytical techniques. Both the T. weissflogii and E. huxleyi exudates contain compounds that resemble APS indicating that phytoplankton are indeed a source of APS to the marine environment. Furthermore, the degradation of the T. weissflogii exudate by a natural assemblage of microorganisms indicates that the component resembling APS is more resistant to microbial degradation compared to other polysaccharides present in the culture. Molecular level analyses show the distribution of monosaccharides to be conservative in surface and deep waters suggesting that APS is present throughout the water column. In order to determine the mechanism by which APS is delivered to the deep ocean the [delta]14C value of APS in the deep ocean was compared to the A14C value of the dissolved inorganic carbon (DIC) at the same depth. If the formation of deep water is the dominant mode of transport then both the DIC and APS will have similar [delta]14C values. However, if APS is injected into the deep ocean from particles or marine snow then the [delta]14C value of APS will be higher than the DIC at the same depth. Our results indicate that APS in the deep Pacific Ocean carries a modem [delta]14C value and is substantially enriched in 14C relative to the total HMW DOM and the DIC at that depth. Thus, particle dissolution appears to be the most important pathway for the delivery of APS to the deep ocean.
by Lihini I. Aluwihare.
Ph.D.
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Quaresma, Joana Rita de Jesus. "Estudo da evolução da cor no processo de refinação de ramas de cana-de-açucar." Master's thesis, ISA/UL, 2019. http://hdl.handle.net/10400.5/18397.

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Mestrado em Engenharia Alimentar - Instituto Superior de Agronomia / UL
A cor da rama, matéria-prima nas refinarias de açúcar, é uma das características fun-damentais; quando acentuada pode afetar o bom funcionamento deste tipo de indústria. A descoloração do licor, remoção dos compostos de cor que estão originalmente na rama da cana-de-açúcar e os que se formam durante o processo de refinação, é uma das fases mais importantes numa refinaria uma vez que no final se pretende produzir açúcar branco. Nos últimos anos a refinaria SIDUL, onde se realizou o presente trabalho, recebeu ra-mas com intensidades de cores bastante elevadas, o que causou um aumento na cor do licor bruto e consequentemente do licor filtrado que segue para descoloração nas resinas. Uma vez que estas não foram dimensionadas para cores de entrada tão altas, a sua performance diminuiu. Como resultado a cor do licor branco aumentou, o que levou ao interesse pela pro-cura de agentes descolorantes que pudessem melhorar estes parâmetros. Numa primeira fase deste trabalho, estudou-se o desempenho de diferentes tipos de polímeros catiónicos, Amber (2009, 2006 e 2001 HMW), tendo o Amber 2001 HMW apresen-tado a melhor relação percentagem de descoloração/preço. Este produto foi de seguida utili-zado nos estudos de descoloração a nível industrial, sendo verificado que esta aplicação era vantajosa, sob os pontos de vista tecnológico e económico, para cores de licor bruto a partir de 2000 UI. Uma vez que a evaporação é a etapa após a descoloração em que pode ocorrer a for-mação de compostos de cor, sendo por isso importante minimizar esta ocorrência, foi ainda estudado o eventual aumento de cor do licor no evaporador com a variação da pressão do vapor de aquecimento (115 kPa, 120 kPa e 125 kPa). Contrariamente ao esperado, não houve elevação expressiva da temperatura do licor, resultando na ausência de um aumento significativo de cor
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Atanassova, Vessela. "Les prêtres Hmw-ntr du culte divin (de l’époque thinite à la fin de l’Ancien Empire)." Thesis, Paris 4, 2015. http://www.theses.fr/2015PA040226.

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Les prêtres sont une partie indissociable de l’organisation et du fonctionnement de la société égyptienne. Parmi eux les prophètes avaient une grande importance dans le clergé égyptien. Leur étude nous permet non seulement une meilleure compréhension du sacerdoce égyptien, mais aussi une meilleure connaissance de la religion égyptienne. Concentrée sur l’époque thinite et l’Ancien Empire, notre recherche a fait l’examen exhaustif des titulaires des prêtrises divines afin de comprendre les mécanismes de l’obtention de celle-ci et les fonctions déléguées aux prophètes. L’examen de sources nous a parmi d’attester une relation entre fonction civile et prêtrise divine qui est étudiée en détail. Nous discuterons la chronologie des prêtrises, les divinités concernées et la nature de ses titulaires. Nous interrogeons sur l’obtention et la transmission de la prêtrise divine. Enfin, nous poserons la question sur les lieux d’exercice de la fonction sacerdotale, ainsi que sur ce que celle-ci devait être
The priests were an inseparable part of the organisation and functioning of the Egyptian society. Among them the prophets were one of the most important for the Egyptian clergy. The study of them allows us not only a better comprehension ofthe Egyptian priesthood but also a better knowledge of the Egyptian religion. Focused on the Early dynastic period and the Old Kingdom our research examinedthe holders of the divine priesthoods in order to understand the ways of having andobtaining it. The study of the sources allowed us to attest a relation between the civil service and the divine priesthood. We discussed the priesthood’s chronology, the mentioned gods and its holders. We question about its obtainment and transmission. At last, we focused on finding the place of exercise of the priesthood and its significance
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Liao, Siyun. "The Role of Fibroblast Growth Factor-2 Isoforms in Ischemia-reperfusion Injury and Cardioprotection." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1203690695.

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Pierucci, Valquiria Resende Malaspina. "An investigation of the effects of high molecular weight glutenin subunits on wheat tortilla quality." Thesis, Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/750.

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Schmid, Markus Josef Anton [Verfasser], Peter [Akademischer Betreuer] Köhler, Peter [Gutachter] Köhler, and Stephan [Gutachter] Sieber. "Isolation and proteinchemical characterization of HMW-gliadins from wheat flour / Markus Josef Anton Schmid ; Gutachter: Peter Köhler, Stephan Sieber ; Betreuer: Peter Köhler." München : Universitätsbibliothek der TU München, 2018. http://d-nb.info/1164590987/34.

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Wurster, Elena [Verfasser]. "Vergleichende Genexpressionsanalyse in viszeralem Fettgewebe von Patienten mit Colorektalen Karzinomen und Adipositas sowie Nachweis der Expression von HMW- Adiponektin im Serum / Elena Wurster." Ulm : Universität Ulm. Medizinische Fakultät, 2015. http://d-nb.info/1071629255/34.

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Echeverri, Christophe de Jesus. "A comparative study of high and low molecular weight microtubule-associated protein 2 (HMW-MAP2 and MAP2c) in differentiating neurons and transfected fibroblasts cells." Thesis, University of Ottawa (Canada), 1993. http://hdl.handle.net/10393/6823.

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Microtubule-associated protein 2 (MAP2) is the most abundant MAP in vertebrate brain tissues, and the best studied of all structural MAPs. In adult brain, it is present as one or two high-molecular weight polypeptides (HMW-MAP2, $\sim$280kDa by SDS-PAGE) which segregate to the somato-dendritic compartments of neurons. Apart from its ontogeny and sequence, little is known about MAP2c biochemistry, although sequence similarities with HMW-MAP2 suggest that the smaller isoform should also bind to MTs, promote their assembly, stabilize them, and possibly induce bundling. This thesis aimed to examine these questions about MAP2c by studying it in parallel with HMW-MAP2 both in differentiating neurons, and in transfected fibroblasts. Neuronal differentiation was examined in retinoic acid-induced P19 embryonal carcinoma cells, using an anti-$\beta$III-tubulin antibody to identify neurons. Expression of MAP2 was examined using three monoclonal antibodies, two of which (HM2 and AP18) recognized all forms of MAP2, while the third (AP14) was specific for HMW-MAP2. Onset of detectable expression of MAP2 was found to coincide with initial neurite outgrowth of P19 EC-derived neurons. The HM2 antibody stained almost all visible neurons, while AP18 stained a smaller subset, and AP14, the smallest. Only the HM2 antibody stained filopodia on some cell bodies and neurite shafts, as well as some growth cones. It is proposed that MAP2 is present as two or more subpopulations which sort differently within the cell. Transient transfections into 3T3 fibroblasts confirmed that MAP2c binds to MTs, stabilizes them against colchicine-induced depolymerization, and induces the formation of MT bundles. It is proposed that MAP2-induced bundles initially arise through the funnelling of MTOC-based MTs into thin cytoplasmic extensions which are eventually resorbed into the cell body. MT bundles are then released from the MTOC, and their stability is slightly decreased as a result. (Abstract shortened by UMI.)
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Bröder, Lisa-Marie. "Transport, degradation and burial of organic matter released from permafrost to the East Siberian Arctic Shelf." Doctoral thesis, Stockholms universitet, Institutionen för miljövetenskap och analytisk kemi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-136380.

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Permafrost soils in the Arctic store large quantities of organic matter, roughly twice the amount of carbon that was present in the atmosphere before the industrial revolution. This freeze-locked carbon pool is susceptible to thawing caused by amplified global warming at high latitudes. The remobilization of old permafrost carbon facilitates its degradation to carbon dioxide and methane, thereby providing a positive feedback to climate change. Accelerating coastal erosion in addition to projected rising river discharge with enhancing sediment loads are anticipated to transport increasing amounts of land-derived organic carbon (OC) to the Arctic Ocean. On its shallow continental shelves, this material may be remineralized in the water column or in the sediments, transported without being altered off shelf towards the deep sea of the Arctic Interior or buried in marine sediments and hence sequestered from the contemporary carbon cycle. The fate of terrigenous material in the marine environment, though offering potentially important mechanisms to either strengthen or attenuate the permafrost-carbon climate feedback, is so far insufficiently understood. In this doctoral thesis, sediments from the wide East Siberian Arctic Shelf, the world’s largest shelf-sea system, were used to investigate some of the key processes for OC cycling. A range of bulk sediment properties, carbon isotopes and molecular markers were employed to elucidate the relative importance of different organic matter sources, the role of cross-shelf transport and the relevance of degradation during transport and after burial. Overall, OC released from thawing permafrost constitutes a significant proportion of the sedimentary organic matter on the East Siberian Arctic Shelf. Two sediment cores from the inner and outer East Siberian Sea recorded no substantial changes in source material or clear trends in degradation status for the last century. With increasing distance from the coast, however, strong gradients were detected towards lower concentrations of increasingly reworked land-derived OC. The time spent during cross-shelf transport was consequently found to exert first-order control on degradation. Compound-specific radiocarbon dating on terrigenous biomarkers revealed a net transport time of ~4 000 years across the 600 km wide Laptev Sea shelf, yielding degradation rate constants for bulk terrigenous OC and specific biomarkers on the order of 2-4 kyr-1. From these results, the carbon flux released by degradation of terrigenous OC in surface sediments was estimated to be ~1.7 Gg yr-1, several orders of magnitude lower than what had been quantified earlier for dissolved and particulate OC in the water column. Lower oxygen availability and close associations with the mineral matrix may protect sedimentary OC from remineralization and thereby weaken the permafrost-carbon feedback to present climate change.

At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 3: Submitted. Paper 4: Manuscript.

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Books on the topic "HMW"

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Aluwihare, Lihini I. High molecular weight (HMW) dissolved organic matter (DOM) in seawater: Chemical structure, sources and cycling. Woods Hole, Mass: Massachusetts Institute of Technology, Woods Hole Oceanographic Institution, Joint Program in Oceanography/Applied Ocean Science and Engineering, 1999.

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Loch, L. Iain. H.M.S. Winchester: The brief history of a British frigate (1822-1861). Liverpool: The Author, 2005.

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Andrews, Frank. A numerical listing of the HMV "B" series of 78 rpm records. Wells-Next-The-Sea: City of London Phonograph and Gramophone Society Ltd, 2000.

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Andrews, Frank. A numerical listing of the HMV "B" series of 78 rpm records. Wells-Next-The-Sea: City of London Phonograph and Gramophone Society Ltd., 2000.

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Thorburn, Gordon. Village cricket: The genuine article. Appleby-in-Westmorland: Fido, 1996.

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Prāp sưk Hō̜: Songkhrām thī yư̄a wēlā kwā 10 pī, songkhrām thī plon, khā, kō̜ khwāmwunwāi nai ʻānāčhak Sayām čhon tō̜ng banthưk pen ʻīk nưng prawattisāt thī nā čhotčham. Krung Thēp: Samnakphim Sayām Khwāmrū, 2013.

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Innes-Smith, James. Hew, screw, and glue: How stuff is made. New York: Abrams Image, 2009.

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Press, Aneko, ed. How to Study the Bible: Those who love thy law have great peace, and nothing shall cause them to stumble. (Psalm 119:165). Abbotsford, USA: Aneko Press, 2017.

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Vordermaier, Sonja. Sonja Vordermaier: H.W. & J. Hector Kunstpreis 2006, Kunsthalle Mannheim. Mannheim: Revolver, 2007.

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The torpedomen: HMS Vernon's story 1872-1986. [Portsmouth]: [Project Committee, H.M.S. Vernon], 1993.

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Book chapters on the topic "HMW"

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Hua, Xin, Jiang Ying, Gao Kaiming, Gu Qimin, Jiang Xuejun, Huang Weida, and Sun CHongrong. "Studies on Wheat HMW Glutenin Gene." In Biotechnology in Agriculture, 200–203. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1779-1_30.

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Oh-ishi, Sachiko, Izumi Hayashi, Kohji Yamaki, Iku Utsunomiya, Masahiko Hayashi, Akiko Yamasu, and Takeshi Nakano. "Role of High Molecular Weight (HMW)-Kininogen in Inflammatory Exudation: Evidence With the Studies of the Hmw-Kininogen Deficient Rat." In Advances in Experimental Medicine and Biology, 145–52. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4615-9543-4_20.

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Foster, B. J., and M. Roberson. "Removal of HMW Organic Compounds by Partial Wet Oxidation." In Essential Readings in Light Metals, 297–303. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118647868.ch40.

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Foster, B. J., and M. L. Roberson. "Removal of HMW Organic Compounds by Partial Wet Oxidation." In Essential Readings in Light Metals, 297–303. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-48176-0_40.

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de Bustos, A., P. Rubio, C. Soler, P. García, and N. Jouve. "Marker Assisted Selection to Improve HMW-Glutenins in Wheat." In Wheat in a Global Environment, 171–76. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-017-3674-9_19.

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Ohkubo, Iwao, Shigeki Higashiyama, and Makoto Sasaki. "Monoclonal Antibodies against the Complex Between HMW Kininogen and Calpain I." In Advances in Experimental Medicine and Biology, 305–10. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4615-9546-5_51.

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Barro, F., L. Rooke, A. S. Tatham, P. R. Shewry, A. Martin, P. A. Lazzeri, and P. Barcelo. "Expression of HMW Glutenin Genes in Transgenic Wheat and Tritordeum Plants." In Plant Proteins from European Crops, 64–69. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-662-03720-1_11.

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Shewry, P., J. Greenfield, F. Buonocore, N. Wellner, P. S. Belton, O. Parchment, D. Osguthorpe, and A. S. Tatham. "Conformational Studies of the Repetitive Sequences of HMW Subunits of Wheat Glutenin." In Plant Proteins from European Crops, 120–25. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-662-03720-1_20.

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Bekes, F., O. Anderson, P. W. Gras, R. B. Gupta, A. Tam, C. W. Wrigley, and R. Appels. "The Contributions To Mixing Properties of 1D HMW Glutenin Subunits Expressed in a Bacterial System." In Improvement of Cereal Quality by Genetic Engineering, 97–103. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2441-0_12.

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He, G. Y., R. D’ovidio, O. D. Anderson, R. Fido, A. S. Tatham, H. Darlington, J. Napier, P. A. Lazzeri, H. D. Jones, and P. R. Shewry. "Expression of HMW Subunit, γ-Zein and uidA Genes in Endosperms of Transgenic Bread Wheat." In Wheat in a Global Environment, 177–81. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-017-3674-9_20.

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Conference papers on the topic "HMW"

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Ishiguro, H., S. Higashiyama, C. Namikawa, I. Ohkubo, and M. Sasaki. "MAPPING OF FUNCTIONAL DOMAINS OF HUMAN HIGH MOLECULAR WEIGHT (HMW) AND LOW MOLECULAR WEIGHT (LMW) KININOGENS BY USING MURINE MONOCLONAL ANTIBODIES (MAbs)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642849.

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It has been widely known that HMW and LMW kininogens are the large potential sources of kinin in human blood, and that HMW kininogen also functions as a cofactor in the contact activation of blood coagulation. Recently, it has been demonstrated that the heavy chains of kininogens strongly inhibited a number of cysteine proteinases such as calpains, cathepsins, papain and ficin. We made an attempt at mapping of functional domains on the molecules of both kininogens by using MAbs.Thirty four MAbs raised against human HMW and LMW kininogens were screened by ELISA. By using HMW kininogen, kinin-free HMW kininogen, kinin and fragment 1.2 (fr 1.2)-free HMW kininogen, LMW kininogen, kinin-free LMW kininogen, heavy chain of LMW kininogen and light chains of both kininogens, the MAbs were characterized and.classified into four groups; [1] 20 MAbs reacted with heavy chain, a common region of HMW and LMW kininogens. These MAbs possessed the specificity for domain 1 (2 MAbs), domain 2 (2 MAbs), domain 3 (7 MAbs), and both domains 2 and 3 (7 MAbs) of the heavy chain; [2] 7 MAbs recognized the fr 1.2, a unique histidine-rich region; [3] 5 MAbs reacted with the light chain of HMW kininogen; [4] 2 MAbs recognized the light chain of LMW kininogen.Two MAbs, designated HKG H7 and H12, effectively inhibited the cysteine proteinase inhibitor activity of HMW and LMW kininogens and the others did not affect it. Further, the MAbs, which recognized the fr 1.2 or light chain of HMW kininogen, suppressed the clotting activity. Especially, 2 MAbs, named HKG L2 and L5, effectively suppressed the clotting activity of HMW kininogen. The former, which neutralized about 70% of the clotting activity, reacted specifically with fr 1.2 region of HMW kininogen, and the latter, which neutralized more than 90% of it, recognized the light chain of HMW kininogen. In the results of competition ELISA, fr 1.2 specific MAbs could be classified into 5 kinds of MAbs for recognition sites, and the light chain (HMW kininogen)-specific MAbs also could be classified into 3 kinds of MAbs. Further, 2 light chain (LMW kininogen)-specific MAbs were thought to recognize an identical antigenic site.
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Checchetti, Maurizio. "High-power DPSS Laser hosted on a HMW-THS." In Lasers and Applications in Science and Engineering, edited by Hanna J. Hoffman, Ramesh K. Shori, and Norman Hodgson. SPIE, 2007. http://dx.doi.org/10.1117/12.705244.

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Kleniewski, J., and V. H. Donaldson. "LIMITED CLEAVAGE OF HMW-KININOGEN BY PLASMIN ENHANCES RELEASE OF KININ BY PLASMA KALLIKREIN: CLEAVAGE BY LEUKOCYTE ELASTASE DOES NOT RELEASE KININ, BUT INACTIVATES ITS COAGULANT PROPERTIES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643895.

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After limited digestion of purified human HMW-kininogen by plasmin, the kininogen molecule consists of two disulfide-linked chains in which the bradykinin sequence resides in the "light chain" portion. Kinin was released from this molecule by plasma kallikrein at a two- to three-fold more rapid rate than from uncleaved HMW-kininogen. Similarly, when normal human plasma or prekallikrein deficient plasma was treated with sufficient streptokinase to activate plasminogen the subsequent rate of release of kinin by kallikrein was enhanced. The digestion of HMW-kininogen by plasmin as well as kinin relea^s was inhibited by epsilon aminocaproic acid at a concentration of 10−3 M, suggesting that one or more lysine residues was critical to the plasmin-HMW-kininogen interaction. Leukocyte elastase cleaved HMW-kininogen into low molecular weight fragments without releasing kinin but plasma kallikrein could then release kinin from a low molecular weight component of elastase-digested HMW-kininogen (≦50 kd mol. wt.). Elastase destroyed the coagulant properties of the kininogenWhen HMW-kininogen was converted to two-chain, disuifide-linked molecules, either by plasmin or kallikrein, the quantity of antigen detected in an ELISA with polyclonal antibody to human light chain antigens was significantly increased. Expression of antigen detectable with a monoclonal antibody to an epitope located close to the disulfide interchange in the light chain was not increased by prior limited digestion with these enzymesIt is possible that minimal activation of plasminogen in vivo may facilitate kinin release by kallikrein. In addition, in quantifying antigenic properties of HMW-kininogen in plasma, care should be taken to block in vitro activation of plasminogen or prekallikrein. Since leukocyte elastase can be released during clotting of whole blood, it might then serve as a regulator of coagulation through its inactivation of coagulant properties of HMW-kininogen
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Higashiyama, S., I. Ohkubo, H. Ishiguro, and M. Sasaki. "A NEW FUNCTION OF HUMAN KININOGENS: THE AMINO-TERMINAL REGION OF DOMAIN 1 INVOLVES AN EF HAND-LIKE STRACTURE FOR METAL BINDING." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642851.

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Two types of kininogens in mammalian plasma, high molecular weight (HMW) and low molecular weight (LMW) kininogens, are the precursors of kinin. Especially, HMW kininogen circulates in the plasma as a complex with prekallikrein and factor XI, and functions as a cofactor in the initial phase reactions of intrinsic blood coagulation cascade. Recently, it has been found that the kininogens have inhibitory activity toward cysteine proteinases. The heavy chain portion, which is identical for HMW and LMW kininogens, is composed of three domains, domain 1, 2 and 3. Each the domain 2 and 3 has a reactive site as a cysteine proteinase inhibitor. However, physiological function of domain 1 remains still unknown. By using the antibody recognizing the interaction between HMW kininogen and Ca2+ (anti-HMW kininogen-Ca2+ antibody) as a probe, we newly found the Ca2+ binding site in the domain 1.Anti-HMW kininogen-Ca2+ antibody was isolated from anti-HMW kininogen antiserum as an antibody which bound to a HMW kininogen-Sepharose column equilibrated with 40 mM Tris-HCl buffer, pH 7.5, containing 1.0 M NaCl and 1 mM CaCl2, and was eluted with 3 mM EDTA. Resulting from the characterization by ELISA, this antibody specifically recognized the CB-1 region (CNBr-cleavage fragment 1: 1-160 amino acid sequence) of the heavy chain of kininogen molecules in the presence of Ca2+ or Mg2+. Furthermore, circular dichroism (CD) experiments showed that the conformational changes of HMW kininogen and heavy chain were induced by the addition of metal ions such as Ca2+ or Mg2+, and that this change was due to the conformational change of the CB-1 region. The dissociation constant (Kd) for heavy chain measured by Ca2+ titration analysis by CD at 214 nm was found to be 0.33 ± 0.09 mM. The number of Ca2+ binding sites of heavy chain calculated from Hill plot was 1.15 ± 0.04. The EF handlike structure found in the amino-terminal portion of the heavy chain of kininogen molecules strongly supported the above data. This indicates a possibility that kininogens play an important role as a Ca2+ binding protein.
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Huang, Ruying, Weijun Tian, and Huibo Yu. "Enhanced Biodegradation of HMW- PAHs using Immobilized Microorganisms in an Estuarine Reed Wetlands Simulator." In 2015 International Power, Electronics and Materials Engineering Conference. Paris, France: Atlantis Press, 2015. http://dx.doi.org/10.2991/ipemec-15.2015.213.

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Chediak, J., B. Maxey, J. Eldridge, and M. C. Telfer. "HETEROGENOUS RESPONSES TO CRYOPRECIPITATE AND DDAVP IN TYPE IIA VON WILLEBRAND'S DISEASE (VWD)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644120.

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Von Willebrand's disease is an autosomal dominant disorder characterized by excessive mucocutaneous bleeding, prolonged bleeding time (BT), and reduce amounts of ristocetin cofactor activity (RiCof). The Von Willebrand factor antigen (VWF:Ag) shows either reduced amounts or no multimers (Types I and III), or a selective reduction of high molecular weight multimers (HMW) (Type IIA and IIB). Variable responses to DDAVP have been reported in IIA VWD suggesting that IIA patients (pts) are a heterogenous group. Some IIA pts may show RiCcf activity after DDAVP infusion even though no HMW multimers are found.Von Willebrand factor antigen, RiCof and BT were analyzed in five pts (2 females and 3 males) known to have Type IIA VWD. Baseline values shov/ed marked reductions of RiCof (less than 13% of normal), BT greater than 15 minutes, faster immunoelectrophoresis of VWF:Ag and absent HMW multimers. Immunoelectrophoresis of VWF:Ag by the Laurell technique gave variable amounts ranging from 10 to 125% or normal. Three adult pts received DDAVP (Stimate) or cryoprecipitate (cryo) and the responses on abnormal parameters were assessed up to 48 hours. In two pts the BT corrected with cryo, whereas in the third patient the correction was minimal. The three pts showed a normal decay of both VWF:Ag or RiCof after cryo. However, after DDAVP the decay of VWF:Ag and RiCof was similar to that after cryo in one patient and more rapid in two patients.In these two patients, the data would be compatible with the rapid proteolysis of endogenoue VWF released by the patient's endothelial cells, whereas the exogenous VWF given as cryo showed normal survival in the patient's blood.
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Lu, Jerry, William Hanna, Lucas S. Kumosa, Megha Bhalla, Veronica W. Cheung, Robert P. Turner, James P. McCanna, Eugene Tu, David J. Charlot, and Rajaram Krishnan. "Abstract 1704: AC electrokinetic isolation of cell free high molecular weight DNA (CF-HMW DNA) from serum." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1704.

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Lipinska, I., C. Perlgrund, T. Wharton, and Y. Gurewich. "FIBRINOGEN HETEROGENEITY AND FIBRINOLYTIC ACTIVITY IN AN6I0GRAPHICALLY ASSESSED CORONARY ARTERY DISEASE (CAD)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643027.

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Human plasma was shown previously to contain three forms of thrombin clottable protein: high molecular (HMW) and two lower molecular weight fibrinogen (LMW and LMW*) , the percentage of which in healthy subject is 69, 28 and 32 respectively. Significant abnormalities in the proportion of fibrinogen (Fgb) fractions were observed post–surgically, in cancer, and in patients with myocardial infarction and liver diseases. The aim of this study was to determine Fbg fractions and fibrinolytic activity (FA) in patients with and without proven coronary occlusion. Group I consisted of 21 symptomatic patients without significant coronary obstruction. Group II comprised 116 patients (94 men and 43 women; mean age 65 and 59 y. respectively) who were shown by angiographical examination to have coronary artery occlusions. Plasma Fbg fractions were determined by 3.52 SDS–PA6E of washed fibrin nonstabilized clots dissolved in 8M urea. Quantitation of the fractions were perfomed by densitometric scanning and expressed as percent of total. Fibrinolytic activity was measured in euglobulin fraction using fibrin plate technique. Mean values for HMW, LMW and LMW’ fibrinogen fractions were 64.4±4, 28.8±2 and 6.6±1 for Group I, and 62.5±5, 29.8±3 and 7.7± 1 for Group II respectively. Fibrinolytic activity in Group I and II was 66±26 and 39±24mm2 respectively as compared to 86±35 in healthy subjects. The statistically significant differences between Group I and II were observed for HMW and LMW fractions (p<0.03) and for FA (p<0.001). These results indicate that measurement of blood FA can be useful in the identification of individuals at risk for coronary artery disease. It is also concluded that degradation of plasma fibrinogen is not related to the fibrinolytic activty of blood, but is caused by some other mechanism, as yet not known.
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Lecander, I., and B. Åstedt. "OCCURRENCE OF PAI-2 IN MEN AND NON-PREGNANT WOMEN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644458.

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PAI-2 is a specific plasminogen activator inhibitor most likely produced in the trophoblasts of placenta but presumably also in certain macrophages. It occurs in two molecular froms of 48 and 60 kDa. From placenta homogenates mainly the LMW-form can be isolated. During pregnancy mainly the HMW-form increases in the blood and disappears after delivery.We examined blood samples from 120 male blood donors (females excluded to avoid unknown pregnancies) and 20 staff members, 4 males and 16 females for the presence of PAI-2.PAI-2 antigen levels were measured with a sandwich ELISA using a polyclonal and a monoclonal antibody. The concentration was given in per cent of that in pooled term plasma.PAI-2 antigen was detected in 5 of the blood donors 9, 12, 22, 31 and 60 %. In one male staff member the antigen concentration was 9 % and in one female 72 %. Repeated analyzes of this last member for six months resulted in values between 30-90 %. Immunoblotting using a monoclonal antibody against PAI-2 showed a HMW-band of about 80 kDa.
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Singleton, PA, N. Mambetsariev, and JG Garcia. "The Mammalian Target of Rapamycin (mTOR) Is a Novel Regulator of HMW-Hyaluronan-Mediated Pulmonary Endothelial Barrier Enhancement." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2318.

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Reports on the topic "HMW"

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Pelletier, Austin, Amanda Hohner, Idil Deniz Akin, Indranil Chowdhury, Richard Watts, Xianming Shi, Brendan Dutmer, and James Mueller. Bench-scale Electrochemical Treatment of Co-contaminated Clayey Soil. Illinois Center for Transportation, June 2021. http://dx.doi.org/10.36501/0197-9191/21-018.

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Industrial soil contamination is frequently unearthed by transportation agencies during construction within the right-of-way. As a result, transportation agencies may experience construction delays. Soils co-contaminated with high-molecular-weight polycyclic aromatic hydrocarbons (HMW-PAHs) and metals are commonly encountered in Illinois and exhibit recalcitrance towards conventional treatment technologies. This issue is exacerbated in the fine-grained soils common to Illinois, where low-permeability and immense sorption capacity increase treatment complexity, cost, and duration. Contaminated sites are spatially and temporally restrictive and require rapid in situ treatments, whereas conventional soil remediation requires 1 to 3 years on average. Consequently, transportation agencies typically pursue excavation and off-site disposal for expediency. However, this solution is expensive, so a comparatively expeditious and affordable treatment alternative is needed to combat the increasing cost of hazardous waste disposal. The objective of this work was to develop an accelerated in situ treatment approach adaptable for use at any construction site to cost-effectively remove HMW-PAHs and metals from clayey soil. It was hypothesized that an in situ electrochemical treatment which augments electrokinetics with H2O2 could remediate both HMW-PAHs and metals in less than a month. Bench-scale reactors resemblant of field-scale in situ electrokinetic systems were designed and fabricated to assess the electrochemical treatment of clayey soils contaminated with HMW-PAHs and metals. Pyrene, chromium, and manganese were used as model contaminants, spiked into kaolinite as a model clay. Electrokinetics were imposed by a low-intensity electrical field distributed by graphite rods. Electrolytic H2O2 systems were leveraged to distribute electrical current and facilitate contaminant removal. Average contaminant removals of 100%, 42.3%, and 4.5% were achieved for pyrene, manganese, and chromium, respectively. Successful development of this bench-scale treatment approach will serve to guide transportation agencies in field-scale implementation. The results from this work signify that electrochemical systems that leverage eco-friendly oxidant addition can replace excavation and disposal as a means of addressing clayey soils co-contaminated with HMW-PAHs and metals.
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Burpo, F. J. Organizational Adaptive Capacity: How Much, How Fast, and How Often. Fort Belvoir, VA: Defense Technical Information Center, March 2012. http://dx.doi.org/10.21236/ada568439.

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Philip Kukulski, Philip Kukulski. Round Goby assault on American rivers: How fast, how far, how complete? Experiment, June 2016. http://dx.doi.org/10.18258/7229.

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Kimball, Lisa. How We Learn and How to Change. Boston, MA: Patricia Seybold Group, March 2013. http://dx.doi.org/10.1571/i03-28-13cc.

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Skone, Timothy J. HLW Disposition. Office of Scientific and Technical Information (OSTI), August 2011. http://dx.doi.org/10.2172/1509389.

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Grajewski, Gregory. Supply Chain Basics: Technology, How Much – How Soon. U.S. Dept. of Agriculture, Agricultural Marketing Service, July 2007. http://dx.doi.org/10.9752/ms028.07-2007.

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Matyas, Josef, Adam R. Huckleberry, Carmen P. Rodriguez, Jesse B. Lang, Antionette T. Owen, and Albert A. Kruger. HLW Glass Studies: Development of Crystal-Tolerant HLW Glasses. Office of Scientific and Technical Information (OSTI), April 2012. http://dx.doi.org/10.2172/1062511.

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Fitzgerald, Doireann, Stefanie Haller, and Yaniv Yedid-Levi. How Exporters Grow. Cambridge, MA: National Bureau of Economic Research, January 2016. http://dx.doi.org/10.3386/w21935.

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Jankovsky, Zachary Kyle, Troy Christopher Haskin, and Matthew R. Denman. How to ADAPT. Office of Scientific and Technical Information (OSTI), June 2018. http://dx.doi.org/10.2172/1457610.

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Spies, Samuel. How Misinformation Spreads. MediaWell, Social Science Research Council, July 2020. http://dx.doi.org/10.35650/md.2067.d.2020.

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