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Dissertations / Theses on the topic 'HMW'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Alrawi, Sura, and Manar Younan. "High Molecular Weight (HMW) snabbtypning av Clostridium difficile med MALDI-TOF MS : Genom två metoder direkt och proteinextraktion." Thesis, Hälsohögskolan, Högskolan i Jönköping, HHJ. Biomedicinsk plattform, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-31515.

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Aluwihare, Lihini Indira. "High molecular weight (HMW) dissolved organic matter (DOM) in seawater : chemical structure, dources and cycling." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/53038.

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Thesis (Ph. D.)--Joint Program in Chemical Oceanography (Massachusetts Institute of Technology, Dept. of Earth, Atmospheric and Planetary Sciences; and the Woods Hole Oceanographic Institution), 1999.<br>Includes bibliographical references.<br>The goal of this thesis was to use high resolution analytical techniques coupled with molecular level analyses to chemically characterize high molecular weight (> 1 k Da (HMW)) dissolved organic matter (DOM) isolated from seawater in an attempt to provide new insights in to the cycling of DOM in the ocean. While a variety of sites spanning different envi

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Quaresma, Joana Rita de Jesus. "Estudo da evolução da cor no processo de refinação de ramas de cana-de-açucar." Master's thesis, ISA/UL, 2019. http://hdl.handle.net/10400.5/18397.

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Mestrado em Engenharia Alimentar - Instituto Superior de Agronomia / UL<br>A cor da rama, matéria-prima nas refinarias de açúcar, é uma das características fun-damentais; quando acentuada pode afetar o bom funcionamento deste tipo de indústria. A descoloração do licor, remoção dos compostos de cor que estão originalmente na rama da cana-de-açúcar e os que se formam durante o processo de refinação, é uma das fases mais importantes numa refinaria uma vez que no final se pretende produzir açúcar branco. Nos últimos anos a refinaria SIDUL, onde se realizou o presente trabalho, recebeu ra-mas com

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Atanassova, Vessela. "Les prêtres Hmw-ntr du culte divin (de l’époque thinite à la fin de l’Ancien Empire)." Thesis, Paris 4, 2015. http://www.theses.fr/2015PA040226.

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Les prêtres sont une partie indissociable de l’organisation et du fonctionnement de la société égyptienne. Parmi eux les prophètes avaient une grande importance dans le clergé égyptien. Leur étude nous permet non seulement une meilleure compréhension du sacerdoce égyptien, mais aussi une meilleure connaissance de la religion égyptienne. Concentrée sur l’époque thinite et l’Ancien Empire, notre recherche a fait l’examen exhaustif des titulaires des prêtrises divines afin de comprendre les mécanismes de l’obtention de celle-ci et les fonctions déléguées aux prophètes. L’examen de sources nous a

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Liao, Siyun. "The Role of Fibroblast Growth Factor-2 Isoforms in Ischemia-reperfusion Injury and Cardioprotection." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1203690695.

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Pierucci, Valquiria Resende Malaspina. "An investigation of the effects of high molecular weight glutenin subunits on wheat tortilla quality." Thesis, Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/750.

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Schmid, Markus Josef Anton [Verfasser], Peter [Akademischer Betreuer] Köhler, Peter [Gutachter] Köhler, and Stephan [Gutachter] Sieber. "Isolation and proteinchemical characterization of HMW-gliadins from wheat flour / Markus Josef Anton Schmid ; Gutachter: Peter Köhler, Stephan Sieber ; Betreuer: Peter Köhler." München : Universitätsbibliothek der TU München, 2018. http://d-nb.info/1164590987/34.

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Wurster, Elena [Verfasser]. "Vergleichende Genexpressionsanalyse in viszeralem Fettgewebe von Patienten mit Colorektalen Karzinomen und Adipositas sowie Nachweis der Expression von HMW- Adiponektin im Serum / Elena Wurster." Ulm : Universität Ulm. Medizinische Fakultät, 2015. http://d-nb.info/1071629255/34.

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Echeverri, Christophe de Jesus. "A comparative study of high and low molecular weight microtubule-associated protein 2 (HMW-MAP2 and MAP2c) in differentiating neurons and transfected fibroblasts cells." Thesis, University of Ottawa (Canada), 1993. http://hdl.handle.net/10393/6823.

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Microtubule-associated protein 2 (MAP2) is the most abundant MAP in vertebrate brain tissues, and the best studied of all structural MAPs. In adult brain, it is present as one or two high-molecular weight polypeptides (HMW-MAP2, $\sim$280kDa by SDS-PAGE) which segregate to the somato-dendritic compartments of neurons. Apart from its ontogeny and sequence, little is known about MAP2c biochemistry, although sequence similarities with HMW-MAP2 suggest that the smaller isoform should also bind to MTs, promote their assembly, stabilize them, and possibly induce bundling. This thesis aimed to examin

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Bröder, Lisa-Marie. "Transport, degradation and burial of organic matter released from permafrost to the East Siberian Arctic Shelf." Doctoral thesis, Stockholms universitet, Institutionen för miljövetenskap och analytisk kemi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-136380.

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Permafrost soils in the Arctic store large quantities of organic matter, roughly twice the amount of carbon that was present in the atmosphere before the industrial revolution. This freeze-locked carbon pool is susceptible to thawing caused by amplified global warming at high latitudes. The remobilization of old permafrost carbon facilitates its degradation to carbon dioxide and methane, thereby providing a positive feedback to climate change. Accelerating coastal erosion in addition to projected rising river discharge with enhancing sediment loads are anticipated to transport increasing amoun

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Pierce, Kyle C., and Michael H. Stone. "Children and Sport – How Hard Should Children Be Trained?" Digital Commons @ East Tennessee State University, 2017. https://doi.org/10.7707/hmj.730.

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The participation of children and early and late adolescents in resistance training activities, including training for sport, appears to continually be on the rise. The involvement of youth in the sport of weightlifting and the use of weightlifting methods as part of training for sport performance also appears to be growing. The increased acceptance of these activities is evidenced by the number of both lay and scientific articles, specialized magazines and publications devoted to the different types of resistance training. It is also indicated by simple observation of fitness centres and spor

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Steyrer, Johannes, Michael Schiffinger, Huber Clemens, Andreas Valentin, and Guido Strunk. "Attitude is everything? The impact of workload, safety climate, and safety tools on medical errors: A study of intensive care units." Lippincott Williams & Wilkins, 2013. http://dx.doi.org/10.1097/HMR.0b013e318272935a.

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Background: Hospitals face an increasing pressure towards efficiency and cost reduction while ensuring patient safety. This warrants a closer examination of the trade-off between production and protection posited in the literature for a high-risk hospital setting (intensive care). Purposes: Based on extant literature and concepts on both safety management and organizational/safety culture, this study investigates to which extent production pressure (i.e., increased staff workload and capacity utilization) and safety culture (consisting of safety climate among staff and safety tools implemente

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Freitag, Walburga. "Contergan eine genealogische Studie des Zusammenhangs wissenschaftlicher Diskurse und biographischer Erfahrungen." Münster New York München Berlin Waxmann, 2003. http://www.waxmann.com/kat/1503.hml.

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Golz, Sebastian, and Thomas Naumann. "Bautechnische Überflutungsvorsorge für Wohngebäude und kleingewerblich genutzte Gebäude." Hochschule für Technik und Wirtschaft, 2020. https://htw-dresden.qucosa.de/id/qucosa%3A71416.

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Durch die Umsetzung gezielter Maßnahmen der objektspezifischen Bauvorsorge lassen sich überflutungsinduzierte Schäden sowohl an bestehenden als auch an neu zu errichtenden Gebäuden in teils erheblichem Umfang mindern. Der vorliegende Ergebnisbericht des Forschungs- und Entwicklungsvorhabens „Bautechnische Überflutungsvorsorge für Wohngebäude und kleingewerblich genutzte Gebäude“ verdichtet das Wissen über wirksame Handlungsoptionen der Bauvorsorge und unterstützt somit die Praxis bei der Planung robuster Konstruktionen gegenüber Überflutung. Als zentrales Ergebnis des Projekts fungiert ein Ba

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Miersch, Sören, Ralph Schubert, Thomas Schuhmann, et al. "Ceramic-like Composite Systems for Winding Insulation of Electrical Machines." IEEE, 2020. https://htw-dresden.qucosa.de/id/qucosa%3A74384.

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Insulating sheets, impregnants and encapsulation materials commonly used for winding insulation offer low thermal conductivities. This leads to an increased heating of the winding of electrical machines and to the existence of hotspots. The electromagnetical utilization of the machine has to be reduced with respect to the allowed maximum winding temperature. In this paper, the development and experimental investigation of novel polysiloxane composites with ceramic fillers are presented. The materials are tested by means of impregnated and encapsulated samples of a round-wire winding as well as

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Lehmann, Rüdiger. "Improved critical values for extreme normalized and studentized residuals in Gauss-Markov models." Springer Verlag, 2012. https://htw-dresden.qucosa.de/id/qucosa%3A23275.

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We investigate extreme studentized and normalized residuals as test statistics for outlier detection in the Gauss-Markov model possibly not of full rank. We show how critical values (quantile values) of such test statistics are derived from the probability distribution of a single studentized or normalized residual by dividing the level of error probability by the number of residuals. This derivation neglects dependencies between the residuals. We suggest improving this by a procedure based on the Monte Carlo method for the numerical computation of such critical values up to arbitrary precisio

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Lehmann, Rüdiger. "Im Schwerpunkt der Anschlusspunkte – Zur Genauigkeit geodätischer Koordinatentransformationen." Hochschule für Technik und Wirtschaft Dresden, 2010. https://htw-dresden.qucosa.de/id/qucosa%3A23283.

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Eine in der Geoda¨sie bekannte Regel besagt, dass die Genauigkeit zu transformierender Neupunkte im Schwerpunkt der Anschlusspunkte am höchsten ist. Weniger bekannt ist, unter welchen Voraussetzungen dies generell gilt. Allgemein unbekannt ist bisher, auf welche Koordinatentransformationen man diese Regel ausdehnen kann. Wir zeigen dies auf und untersuchen einen Fall, in dem diese Regel nicht gilt. Es stellt sich heraus, dass der am genauesten transformierbare Neupunkt theoretisch sogar außerhalb der konvexen Hülle der Anschlusspunkte liegen kann.<br>A rule well-known in Geodesy states that th

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Lösler, Michael, Torsten Lossin, Alexander Neidhardt, and Rüdiger Lehmann. "Untersuchung zur automatisierten Bestimmung des IVS-Referenzpunktes am TWIN Radioteleskop Wettzell." Hochschule für Technik und Wirtschaft Dresden, 2014. https://htw-dresden.qucosa.de/id/qucosa%3A23284.

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Die Verknüpfung von geodätischen Raumtechniken wie GNSS, DORIS, SLR oder VLBI zur Ableitung eines geodätischen Referenzrahmens wie dem ITRF gelingt erst durch sogenannte Kolokationsstationen. Die geometrischen Beziehungen zwischen den betriebenen Raumtechniken sind dabei aus präzisen lokalen Vermessungen abzuleiten. Es wird ein Konzept zur automatisierten Bestimmung des IVS-Referenzpunktes am TWIN Radioteleskop Wettzell vorgestellt. Erste Untersuchungsergebnisse werden präsentiert.

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Lehmann, Rüdiger. "Observation error model selection by information criteria vs. normality testing." Hochschule für Technik und Wirtschaft Dresden, 2015. https://htw-dresden.qucosa.de/id/qucosa%3A23301.

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To extract the best possible information from geodetic and geophysical observations, it is necessary to select a model of the observation errors, mostly the family of Gaussian normal distributions. However, there are alternatives, typically chosen in the framework of robust M-estimation. We give a synopsis of well-known and less well-known models for observation errors and propose to select a model based on information criteria. In this contribution we compare the Akaike information criterion (AIC) and the Anderson Darling (AD) test and apply them to the test problem of fitting a straight line

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Lehmann, Rüdiger, and Michael Lösler. "Multiple Outlier Detection: Hypothesis Tests versus Model Selection by Information Criteria." Hochschule für Technik und Wirtschaft Dresden, 2016. https://htw-dresden.qucosa.de/id/qucosa%3A23307.

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The detection of multiple outliers can be interpreted as a model selection problem. Models that can be selected are the null model, which indicates an outlier free set of observations, or a class of alternative models, which contain a set of additional bias parameters. A common way to select the right model is by using a statistical hypothesis test. In geodesy data snooping is most popular. Another approach arises from information theory. Here, the Akaike information criterion (AIC) is used to select an appropriate model for a given set of observations. The AIC is based on the Kullback-Leibler

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Böhme, Hans-Joachim, Sven Hellbach, Zdeněk Míkovec, Pavel Slavík, and Markus Wacker. "Proceedings of the 20th Bilateral Student Workshop CTU Prague: Dresden (Germany) 2016." Hochschule für Technik und Wirtschaft Dresden, 2017. https://htw-dresden.qucosa.de/id/qucosa%3A23309.

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This technical report publishes the proceedings of the 20th Prague Workshop, which was held from 25th to 26th November 2016 The workshop offers a possibility for young scientists to present their current research work in the fields of computer graphics, human-computer-interaction, robotics and usability. The works is meant as a platform to bring together researchers from both the Czech Technical University in Prague (CTU) and the University of Applied Sciences Dresden (HTW). The German Academic Exchange Service offers its financial support to allow student participants the bilateral exchange

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Böhme, Hans-Joachim, Sven Hellbach, Zdeněk Míkovec, Pavel Slavík, and Markus Wacker. "Proceedings of the 21th Bilateral Student Workshop CTU Prague: Dresden (Germany) 2017." Hochschule für Technik und Wirtschaft Dresden, 2018. https://htw-dresden.qucosa.de/id/qucosa%3A23315.

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This technical report publishes the proceedings of the 21th Prague Workshop, which was held from 25th to 26th December 2017. The workshop offers a possibility for young scientists to present their current research work in the fields of computer graphics, human-computer-interaction, robotics and usability. The works is meant as a platform to bring together researchers from both the Czech Technical University in Prague (CTU) and the University of Applied Sciences Dresden (HTW). The German Academic Exchange Service offers its financial support to allow student participants the bilateral exchange

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Lehmann, Rüdiger. "On the formulation of the alternative hypothesis for geodetic outlier detection." Springer Verlag, 2013. https://htw-dresden.qucosa.de/id/qucosa%3A23274.

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The concept of outlier detection by statistical hypothesis testing in geodesy is briefly reviewed. The performance of such tests can only be measured or optimized with respect to a proper alternative hypothesis. Firstly, we discuss the important question whether gross errors should be treated as non-random quantities or as random variables. In the first case, the alternative hypothesis must be based on the common mean shift model, while in the second case, the variance inflation model is appropriate. Secondly, we review possible formulations of alternative hypotheses (inherent, deterministic,

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Lehmann, Rüdiger. "The 3σ-rule for outlier detection from the viewpoint of geodetic adjustment". American Society of Civil Engineers, 2013. https://htw-dresden.qucosa.de/id/qucosa%3A23281.

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The so-called 3σ-rule is a simple and widely used heuristic for outlier detection. This term is a generic term of some statistical hypothesis tests whose test statistics are known as normalized or studentized residuals. The conditions, under which this rule is statistically substantiated, were analyzed, and the extent it applies to geodetic least-squares adjustment was investigated. Then, the efficiency or non-efficiency of this method was analyzed and demonstrated on the example of repeated observations.<br>Die sogenannte 3σ-Regel ist eine einfache und weit verbreitete Heuristik für die Ausre

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Lehmann, Rüdiger. "Geodätische Fehlerrechnung mit der skalenkontaminierten Normalverteilung." Hochschule für Technik und Wirtschaft Dresden, 2012. https://htw-dresden.qucosa.de/id/qucosa%3A23282.

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Geodätische Messabweichungen werden oft gut durch Wahrscheinlichkeitsverteilungen beschrieben, die steilgipfliger als die Gaußsche Normalverteilung sind. Das gilt besonders, wenn grobe Messabweichungen nicht völlig ausgeschlossen werden können. Neben einigen in der Geodäsie bisher verwendeten Verteilungen (verallgemeinerte Normalverteilung, Hubers Verteilung) diskutieren wir hier die skalenkontaminierte Normalverteilung, die für die praktische Rechnung einige Vorteile bietet.<br>Geodetic measurement errors are frequently well described by probability distributions, which are more peak-shaped t

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Lehmann, Rüdiger. "Transformation model selection by multiple hypotheses testing." Hochschule für Technik und Wirtschaft Dresden, 2014. https://htw-dresden.qucosa.de/id/qucosa%3A23299.

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Transformations between different geodetic reference frames are often performed such that first the transformation parameters are determined from control points. If in the first place we do not know which of the numerous transformation models is appropriate then we can set up a multiple hypotheses test. The paper extends the common method of testing transformation parameters for significance, to the case that also constraints for such parameters are tested. This provides more flexibility when setting up such a test. One can formulate a general model with a maximum number of transformation para

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Böhme, Hans-Joachim, Sven Hellbach, Zdeněk Míkovec, Pavel Slavík, and Markus Wacker. "Proceedings of the 19th Bilateral Student Workshop CTU Prague: Dresden (Germany) 2015." Hochschule für Technik und Wirtschaft Dresden, 2017. https://htw-dresden.qucosa.de/id/qucosa%3A23308.

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This technical report publishes the proceedings of the 19th Prague Workshop, which was held from 27th to 28. November 2015. The workshop offers a possibility for young scientists to present their current research work in the fields of computer graphics, human-computer-interaction, robotics and usability. The works is meant as a platform to bring together researchers from both the Czech Technical University in Prague (CTU) and the University of Applied Sciences Dresden (HTW). The German Academic Exchange Service offers its financial support to allow student participants the bilateral exchange

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Lehmann, Rüdiger, and Frank Neitzel. "Testing the compatibility of constraints for parameters of a geodetic adjustment model." Springer Verlag, 2013. https://htw-dresden.qucosa.de/id/qucosa%3A23273.

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Geodetic adjustment models are often set up in a way that the model parameters need to fulfil certain constraints. The normalized Lagrange multipliers have been used as a measure of the strength of constraint in such a way that if one of them exceeds in magnitude a certain threshold then the corresponding constraint is likely to be incompatible with the observations and the rest of the constraints. We show that these and similar measures can be deduced as test statistics of a likelihood ratio test of the statistical hypothesis that some constraints are incompatible in the same sense. This has

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Kunath, Maxi. "Erfassung und Bewertung von Quellen im Forstrevier Ottomühle zur Erarbeitung von Handlungsempfehlungen für die Renaturierung oder zukünftige Pflege der Quellbereiche und die forstliche Bewirtschaftung im Umfeld." Bachelor's thesis, Hochschule für Technik und Wirtschaft, 2020. https://htw-dresden.qucosa.de/id/qucosa%3A73113.

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Ziel der vorliegenden Bachelorarbeit war es, die Grundwasseraustritte im Forstrevier Ottomühle zu erfassen und zu bewerten, um Handlungsempfehlungen für die Renaturierung oder zukünftige Pflege der Quellbereiche und die forstliche Bewirtschaftung im Umfeld erarbeiten zu können. Zwischen März und Juni 2020 konnten insgesamt 19 Quellen im Forstrevier Ottomühle auf Grundlage einer Handlungsanleitung des Bayrischen Landesamtes für Umwelt erfasst und nach ihrer Naturnähe bewertet werden. Die vorgefundenen Beeinträchtigungen waren in absteigender Häufigkeit (Anzahl der betroffenen Quellen): • Nicht

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Bielefeld, Malte. "Übertragung von Prinzipien der Ameisenkolonieoptimierung auf eine sich selbst organisierende Produktion." Bachelor's thesis, Hochschule für Technik und Wirtschaft, 2019. https://htw-dresden.qucosa.de/id/qucosa%3A34517.

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Die Bachelorarbeit behandelt die Themen der Selbstorganisation in Produktionssystemen im Kontext von Industrie 4.0. Dabei wird gezeigt, wie man mithilfe von einer Ameisenkolonieoptimierung die Reihenfolgeplanung organisieren kann.:Abbildungsverzeichnis Tabellenverzeichnis Formelverzeichnis 1. Einleitung 1.1. Motivation 1.2. Ziele 1.3. Vorgehensweise 2. Sich selbst organisierende Produktionen 2.1. Begriffserklärung 2.2. Stand der Technik 2.3. Reihenfolgeplanung als ein Problem der Selbstorganisation 2.3.1. Begriffserklärung 2.3.2. Stand der Technik 2.3.3. Umsetzung in einer Selbstorganisation 3

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Lehmann, Rüdiger. "Ebene Geodätische Berechnungen: Internes Manuskript." Hochschule für Technik und Wirtschaft, 2018. https://htw-dresden.qucosa.de/id/qucosa%3A31824.

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Dieses Manuskript entstand aus Vorlesungen über Geodätische Berechnungen an der Hochschule für Technik und Wirtschaft Dresden. Da diese Lehrveranstaltung im ersten oder zweiten Semester stattfindet, werden noch keine Methoden der höheren Mathematik benutzt. Das Themenspektrum beschränkt sich deshalb weitgehend auf elementare Berechnungen in der Ebene.:0 Vorwort 1 Ebene Trigonometrie 1.1 Winkelfunktionen 1.2 Berechnung schiefwinkliger ebener Dreiecke 1.3 Berechnung schiefwinkliger ebener Vierecke 2 Ebene Koordinatenrechnung 2.1 Kartesische und Polarkoordinaten 2.2 Erste Geodätische Grundaufgab

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Böhme, Hans Joachim, Markus Wacker, Pavel Slavík, and Zdeněk Míkovec. "Proceedings of the 22th Bilateral Student Workshop CTU Prague: Dresden (Germany) 2018." Hochschule für Technik und Wirtschaft, 2019. https://htw-dresden.qucosa.de/id/qucosa%3A36112.

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This technical report publishes the proceedings of the 22th Prague Workshop, which was held from 30th November to 1st December 2018. The workshop offers a possibility for young scientists to present their current research work in the fields of computer graphics, human-computer-interaction, robotics and usability. The works is meant as a platform to bring together researchers from both the Czech Technical University in Prague (CTU) and the University of Applied Sciences Dresden (HTW). The German Academic Exchange Service offers its financial support to allow student participants the bilateral e

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Hesse, Elfi, Juliane Baier, and Knut Schmidtke. "FDM-Handbuch für HAW: Handlungshilfe für aktives Forschungsdatenmanagement an Hochschulen für angewandte Wissenschaften." Hochschule für Technik und Wirtschaft, 2019. https://htw-dresden.qucosa.de/id/qucosa%3A36556.

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Das hier vorliegende Handbuch ist im Rahmen des Projektes „Vernetztes Forschungsdatenmanagement an Hochschulen für angewandte Wissenschaften am Beispiel der HTW Dresden – FoDaMa-HTWD“ entstanden.1 Es stellt eine kurze und übersichtliche Zusammenfassung der wichtigsten Erkenntnisse dar, welche während der Projektlaufzeit an der Hochschule für Technik und Wirtschaft Dresden (HTWD) zum Forschungsdatenmanagement (FDM) gewonnen wurden. Die Autor/innen möchten mit diesem Handbuch andere Hochschulen für angewandte Wissenschaften (HAW) bei der Strategieentwicklung und dem notwendigen FDM-Strukturaufba

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Griebsch, Anne. "Untersuchungen zur Klauengesundheit in einem Sächsischen Milchviehbetrieb." Hochschule für Technik und Wirtschaft, 2016. https://htw-dresden.qucosa.de/id/qucosa%3A70549.

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Die Abschlussarbeit beschäftigt sich mit der Klauengesundheit von Deutschen Holsteins Kühen in einem Sächsischen Milchviehbetrieb. Ziel war die Erfassung und Bewertung der Klauenmaße und Klauengesundheit bei unterschiedlicher Laufflächengestaltung. Aufgrund einer hohen Prävalenz von 89,1 % im Bereich Klauen und Gliedmaßen und der starken Abnutzung des vorhandenen Gussasphaltes im Laufstall, wurde nach der Ist-Aufnahme (Klauenschnitt, Erfassung von Klauenkrankheiten und –maßen) im Mai 2016 eine Stallhälfte am Futtertisch komplett mit Gummiboden (Kraiburg Kura P) ausgelegt und zwei Versuchsgru

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Lehmann, Rüdiger. "A universal and robust computation procedure for geometric observations." Hochschule für Technik und Wirtschaft, 2017. https://htw-dresden.qucosa.de/id/qucosa%3A31843.

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This contribution describes an automatic and robust method, which can be applied to all classical geodetic computation problems. Starting from given input quantities (e.g. coordinates of known points, observations) computation opportunities for all other relevant quantities are found. For redundant input quantities there exists a multitude of different computation opportunities from different minimal subsets of input quantities, which are all found automatically, and their results are computed and compared. If the computation is non-unique, but only a finite number of solutions exist, then all

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Aland, Sebastian, Sabine Egerer, John Lowengrub, and Axel Voigt. "Diffuse interface models of locally inextensible vesicles in a viscous fluid." Elsevier, 2014. https://htw-dresden.qucosa.de/id/qucosa%3A32307.

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We present a new diffuse interface model for the dynamics of inextensible vesicles in a viscous fluid with inertial forces. A new feature of this work is the implementation of the local inextensibility condition in the diffuse interface context. Local inextensibility is enforced by using a local Lagrange multiplier, which provides the necessary tension force at the interface. We introduce a new equation for the local Lagrange multiplier whose solution essentially provides a harmonic extension of the multiplier off the interface while maintaining the local inextensibility constraint near the i

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Lehmann, Rüdiger, and Anja Voß-Böhme. "On the statistical power of Baarda’s outlier test and some alternative." Hochschule für Technik und Wirtschaft, 2017. https://htw-dresden.qucosa.de/id/qucosa%3A31756.

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Baarda’s outlier test is one of the best established theories in geodetic practice. The optimal test statistic of the local model test for a single outlier is known as the normalized residual. Also other model disturbances can be detected and identified with this test. It enjoys the property of being a uniformly most powerful invariant (UMPI) test, but is not a uniformly most powerful (UMP) test. In this contribution we will prove that in the class of test statistics following a common central or non-central chi2 distribution, Baarda’s solution is also uniformly most powerful, i.e. UMPchi2 for

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Johnson, Kara. "A Functional Polymorphism in the Epidermal Growth Factor Gene Independently Predicts Clinical Decompensation in HCV-Related Cirrhosis." Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/43.

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Background and Aims: Several single nucleotide polymorphisms (SNPs), including rs4444903 in the epidermal growth factor (EGF) gene, rs12979860 near the interleukin-28B (IL28B) gene, and rs738409 in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene, have been linked to treatment response, steatosis, fibrosis, and development of hepatocellular carcinoma (HCC) in chronic hepatitis C (HCV). No study has comprehensively examined the effects of these SNPs on the natural history of HCV-related cirrhosis. Methods: We performed a retrospective cohort study of 169 subjects with

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Song, Zirui. "Payment Reform in Massachusetts: Health Care Spending and Quality in Accountable Care Organizations Four Years into Global Payment." Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/44.

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Background: The United States health care system faces two fundamental challenges: a high growth rate of health care spending and deficiencies in quality of care. The growth rate of health care spending is the dominant driver of our nation’s long-term federal debt, while the inconsistent quality of care hinders the ability of the health care system to maximize value for patients. To address both of these challenges, public and private payers are increasingly changing the way they pay providers—moving away from fee-for-service towards global payment contracts for groups of providers coming toge

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Lewis, William. "Changes in Language Pathways in Tuberous Sclerosis Complex Patients with Autism." Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/45.

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Tuberous sclerosis complex (TSC) is an autosomal-dominant neurocutaneous disease caused by loss of the TSC1 (encoding hamartin) or TSC2 (encoding tuberin) genes. Neurologic symptoms are common and varied in TSC and include epilepsy and behavioral conditions like autism spectrum disorders (ASD). Between 17 and 61% of children with TSC exhibit symptoms of ASD. The purpose of this study was to investigate a potential correlate of poor neurological outcome in TSC by assessing the integrity of brain language pathways and the relationship to ASD. 42 patients with TSC and 42 age-matched control sub

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Parikh, Ravi B. "DEFINITIVE PRIMARY THERAPY IN PATIENTS PRESENTING WITH OLIGOMETASTATIC NON-SMALL CELL LUNG CANCER (NSCLC)." Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/47.

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Background: Although palliative chemotherapy is the standard of care for patients diagnosed with stage IV NSCLC, patients with a small metastatic burden, “oligometastatic” disease, may benefit from definitive local therapy. Methods: We identified 186 patients (26% of Stage IV patients) prospectively enrolled in our institutional database from 2002-2012 with oligometastatic disease, which we defined as five or fewer distant metastatic lesions at diagnosis. Univariable and multivariable Cox proportional hazards models were used to identify patient and disease factors associated with improved s

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Reidler, Jay S. "Modulation of Pain with Transcranial Direct Current Stimulation and Diffuse Noxious Inhibitory Controls." Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/48.

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Background: While pain is essential for physiological functioning, chronic or pathologic pain is responsible for a major burden of disease in society. Novel approaches to treating acute and chronic pain have employed neuromodulatory tools to target the central and peripheral neural structures that mediate pain. Transcranial direct current stimulation (tDCS), for example, is a safe, non-invasive brain stimulation technique that has been shown in preliminary studies to reduce chronic pain when applied to the primary motor cortex. In contrast to this exogenous neuromodulatory approach, diffuse no

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Mattos, David. "PROPHYLACTIC MASTECTOMIES: OCCULT HISTOLOGY AND FISCAL IMPACTS OF SURVEILLANCE VS. SURGERY." Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/51.

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Introduction: During the last decade, our institution saw a 260% increase in bilateral breast reconstruction cases, consistent with national trends. We reported a drop in average age of prophylactic mastectomy from 57 to 51 years. There is limited data on the likelihood of histological abnormalities in this population. This study measures the prevalence of occult histological findings in prophylactic mastectomy patients. Given the current healthcare reform climate, we estimate the lifetime cost implications of prophylactic mastectomy with immediate reconstruction vs. surveillance. Methods

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Xu, Wenxin. "Optimal Systolic Blood Pressure Target, Time-to-Intensification and Time-to-Follow-up in the Treatment of Hypertension." Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/55.

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Objective: I sought to determine the systolic intensification threshold, time-to-intensification and time-to-follow-up associated with the lowest risk of cardiovascular events or death in primary care patients with hypertension. Methods: A retrospective cohort study of 88,756 patients was performed. Systolic intensification threshold, time-to-intensification and time-to-follow-up were analyzed with respect to risk of acute cardiovascular event or death. The Cox model was adjusted for age, sex, smoking status, socioeconomic deprivation, history of diabetes, cardiovascular disease or CKD, Charls

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Swaminathan, Swarup Sai. "The Role of SPARC in Aqueous Humor Outflow and TGFß2-mediated Ocular Hypertension in a Murine Model." Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/56.

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Glaucoma is the leading cause of irreversible blindness worldwide, and is a major cause of blindness in the United States. It affects approximately 5% of Caucasians and 10% of African- Americans over the age of 60 years. Elevated intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma. Impaired outflow of aqueous humor from the eye is thought to be the cause of pathologically elevated IOP. However, the etiology of outflow impairment is unknown. Anatomically, the aqueous humor drains into the iridocorneal angle of the eye, where the iris inserts at the transition be

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Sethi, Rosh Kumar Viasha. "Technology Adoption in the United States: The Impact of Hospital Market Competition." Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/57.

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Objectives: Technological innovation in medicine is a significant driver of healthcare spending growth in the United States. Factors driving adoption and utilization of new technology is poorly understood, however market forces may play a significant role. Vascular surgery has experienced a surge in development of new devices and serves as an ideal case study. Specifically, the share of total abdominal aortic aneurysm (AAA) repairs performed by endovascular aneurysm repair (EVAR) increased rapidly from 32% in 2001 to 65% in 2006 with considerable variation between states. This paper hypothesiz

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Messmer, Sarah Elizabeth. "A Pilot Study on Women's Health Education in Rural Guatemala: Impact on Beliefs and Behaviors." Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/60.

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Great disparities exist in women’s health outcomes in rural indigenous communities in Guatemala; indigenous women are less likely to utilize family planning and cervical cancer screening services. This pilot study assessed baseline women’s health knowledge and the effects of a comprehensive women’s health course on women’s health knowledge and behaviors. From February to November 2013, 61 participants in a seven-week language-appropriate women’s health curriculum were evaluated before and after the course using a 10-item knowledge assessment. Cervical cancer screening and contraceptive utiliz

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Lin, ChieYu. "Characterization and Optimization of the CRISPR/Cas System for Applications in Genome Engineering." Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/61.

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The ability to precisely manipulate the genome in a targeted manner is fundamental to driving both basic science research and development of medical therapeutics. Until recently, this has been primarily achieved through coupling of a nuclease domain with customizable protein modules that recognize DNA in a sequence-specific manner such as zinc finger or transcription activator-like effector domains. Though these approaches have allowed unprecedented precision in manipulating the genome, in practice they have been limited by the reproducibility, predictability, and specificity of targeted cleav

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Vallurupalli, Mounica. "Identifying Targetable Liabilities in Ewing Sarcoma." Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/62.

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Background: Despite multi-modality therapy, the majority of patients with metastatic or recurrent Ewing sarcoma (ES), the second most common pediatric bone malignancy, will die of their disease. ES tumors express aberrantly activated ETS transcription factors through translocations that fuse the EWS gene to ETS family genes FLI1 or ERG. The aberrant activation of ETS transcription factors promotes malignant transformation and proliferation. While, FLI1 or ERG cannot be readily targeted, there is an opportunity to deploy functional genomics screens, to develop novel therapeutic approaches by i

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Rahman, Rifaquat M. "Magnetic Resonance Imaging for Prediction and Assessment of Treatment Response in Bevacizumab-Treated Recurrent Glioblastoma." Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/65.

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Glioblastoma is the most common primary brain tumor in adults, and it is associated with a dismal prognosis with a median survival of 15 months. Despite treatment with chemotherapy, radiation therapy and surgery, patients inevitably have disease recurrence. Bevacizumab is a monoclonal humanized antibody that inhibits vascular endothelial growth factor signaling, and it has been shown to be effective in recurrent glioblastoma with respect to prolonging progression-free survival (PFS). The use of bevacizumab and other anti-angiogenic agents in recurrent glioblastoma have created novel challenges

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