Academic literature on the topic 'HnRNP A2/B1'

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Journal articles on the topic "HnRNP A2/B1"

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Shi, Stephanie T., Guann-Yi Yu, and Michael M. C. Lai. "Multiple Type A/B Heterogeneous Nuclear Ribonucleoproteins (hnRNPs) Can Replace hnRNP A1 in Mouse Hepatitis Virus RNA Synthesis." Journal of Virology 77, no. 19 (2003): 10584–93. http://dx.doi.org/10.1128/jvi.77.19.10584-10593.2003.

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ABSTRACT Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 has previously been shown to bind mouse hepatitis virus (MHV) RNA at the 3′ end of both plus and minus strands and modulate MHV RNA synthesis. However, a mouse erythroleukemia cell line, CB3, does not express hnRNP A1 but still supports MHV replication, suggesting that alternative proteins can replace hnRNP A1 in cellular functions and viral infection. In this study, we set out to identify these proteins. UV cross-linking experiments revealed that several CB3 cellular proteins similar in size to hnRNP A1 interacted with the MHV RNA. T
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Wang, Tong-Hong, Chin-Chuan Chen, Yuan-Chao Hsiao, et al. "Heterogeneous Nuclear Ribonucleoproteins A1 and A2 Function in Telomerase-Dependent Maintenance of Telomeres." Cancers 11, no. 3 (2019): 334. http://dx.doi.org/10.3390/cancers11030334.

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The A/B subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs A/B), which includes hnRNP A1, A2/B1, and A3, plays an important role in cell proliferation. The simultaneous suppression of hnRNP A1/A2, but not the suppression of hnRNP A1 or A2 alone, has been shown to inhibit cell proliferation and induce apoptosis in cancer cells, but not in mortal normal cells. However, the molecular basis for such a differential inhibition of cell proliferation remains unknown. Here, we show that the simultaneous suppression of hnRNP A1 and hnRNP A2 resulted in dysfunctional telomeres and induced DNA
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Gu, Wenchao, Xiwen Gao, Linxun Wang, et al. "The Expression of hnRNP A2/B1 in Benign and Malignant Lung Lesions and Its Early Diagnosis Value in NSCLC." Contrast Media & Molecular Imaging 2022 (October 5, 2022): 1–6. http://dx.doi.org/10.1155/2022/5687245.

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Lung cancer in its occurrence and development of different stages exist different biological behavior changes. This paper studies the expression of heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 in benign and malignant lung lesions and its early diagnosis value of nonsmall-cell lung cancer (NSCLC), aiming to provide reference for the early diagnosis and therapy of NSCLC. Some lung surgery specimens are selected from January 2021 to March 2022. All cases received no radiotherapy and chemotherapy before surgery, including 90 sufferers with benign lung lesions as the contrast set. hnRNP A2
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Maslyanskiy, Aleksey, Natalya Lazareva, Polina Olinek, et al. "Anti-hnRNP B1 (RA33) Autoantibodies Are Associated with the Clinical Phenotype in Russian Patients with Rheumatoid Arthritis and Systemic Sclerosis." Journal of Immunology Research 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/516593.

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Heterogeneous nuclear ribonucleoproteins (hnRNPs) are potent autoantigenic targets in systemic autoimmune rheumatic diseases (SARD). Loss of tolerance to the RA33 complex consisting of hnRNP A2 and its alternatively spliced variants B1 and B2 has been the interest of rheumatologists. A novel ELISA for the detection of anti-hnRNP B1 autoantibodies has been developed to investigate the prevalence thereof in 397 patients with SARD, including patients with rheumatoid arthritis (RA), spondyloarthropathy (SPA), juvenile chronic arthritis, systemic lupus erythematosus (SLE), systemic sclerosis (SSc),
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Hernández-Díaz, Iván, Teresa Giraldez, Silvia Morales, et al. "Heterogeneous nuclear ribonucleoprotein A2/B1 is a tissue-specific aldosterone target gene with prominent induction in the rat distal colon." American Journal of Physiology-Gastrointestinal and Liver Physiology 304, no. 2 (2013): G122—G131. http://dx.doi.org/10.1152/ajpgi.00130.2012.

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The steroid hormone aldosterone enhances transepithelial Na+ reabsorption in tight epithelia and is crucial to achieve extracellular volume homeostasis and control of blood pressure. One of the main transport pathways regulated by aldosterone involves the epithelial Na+ channel (ENaC), which constitutes the rate-limiting step of Na+ reabsorption in parts of the distal nephron and the collecting duct, the distal colon, and sweat and salivary glands. Although these epithelial tissues share the same receptor for aldosterone (mineralocorticoid receptor, MR), and the same transport system (ENaC), i
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Bozinovic, Ksenija, Taghi Manshouri, Sean M. Post, et al. "Altered Expression and Mutation Analysis Of Heterogeneous Nuclear Ribonucleoprotein k In Bone Marrow Of Primary Myelofibrosis Patients." Blood 122, no. 21 (2013): 5272. http://dx.doi.org/10.1182/blood.v122.21.5272.5272.

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Abstract The heterogeneous nuclear ribonucleoproteins (hnRNPs) are RNA/DNA-binding proteins that consist of several family members: A1, A2, B1, C2 and K. hnRNPs have been implicated in numerous cellular processes and when dysregulated, have been suggested to impact tumorigenesis. hnRNP A2/B1 is overexpressed in some lung cancers and has been suggested to be a useful early detection marker for lung carcinoma. hnRNP K has been reported to associate with colon cancer and directly interacts with DNA, RNA, and proteins to regulate gene expression in numerous cellular processes involved in mitogenic
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Jung, Youngseob, Ji-Young Seo, Hye Guk Ryu, Do-Yeon Kim, Kyung-Ha Lee, and Kyong-Tai Kim. "BDNF-induced local translation of GluA1 is regulated by HNRNP A2/B1." Science Advances 6, no. 47 (2020): eabd2163. http://dx.doi.org/10.1126/sciadv.abd2163.

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The AMPA receptor subunit GluA1 is essential for induction of synaptic plasticity. While various regulatory mechanisms of AMPA receptor expression have been identified, the underlying mechanisms of GluA1 protein synthesis are not fully understood. In neurons, axonal and dendritic mRNAs have been reported to be translated in a cap-independent manner. However, molecular mechanisms of cap-independent translation of synaptic mRNAs remain largely unknown. Here, we show that GluA1 mRNA contains an internal ribosome entry site (IRES) in the 5′UTR. We also demonstrate that heterogeneous nuclear ribonu
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Barnett, S. F., T. A. Theiry, and W. M. LeStourgeon. "The core proteins A2 and B1 exist as (A2)3B1 tetramers in 40S nuclear ribonucleoprotein particles." Molecular and Cellular Biology 11, no. 2 (1991): 864–71. http://dx.doi.org/10.1128/mcb.11.2.864-871.1991.

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The six "core" proteins of HeLa cell 40S nuclear ribonucleoprotein particles (hnRNP particles) package 700-nucleotide lengths of pre-mRNA into a repeating array of regular particles. We have previously shown that the C proteins exist as anisotropic tetramers of (C1)3C2 in 40S hnRNP particles and that each particle probably contains three such tetramers. We report here that proteins A2 and B1 also exist in monoparticles as (A2)3B1 tetramers and that each monoparticle contains at least three such tetramers. Proteins A2 and B1 dissociate from isolated monoparticles as a stable tetramer upon nucle
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Barnett, S. F., T. A. Theiry, and W. M. LeStourgeon. "The core proteins A2 and B1 exist as (A2)3B1 tetramers in 40S nuclear ribonucleoprotein particles." Molecular and Cellular Biology 11, no. 2 (1991): 864–71. http://dx.doi.org/10.1128/mcb.11.2.864.

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The six "core" proteins of HeLa cell 40S nuclear ribonucleoprotein particles (hnRNP particles) package 700-nucleotide lengths of pre-mRNA into a repeating array of regular particles. We have previously shown that the C proteins exist as anisotropic tetramers of (C1)3C2 in 40S hnRNP particles and that each particle probably contains three such tetramers. We report here that proteins A2 and B1 also exist in monoparticles as (A2)3B1 tetramers and that each monoparticle contains at least three such tetramers. Proteins A2 and B1 dissociate from isolated monoparticles as a stable tetramer upon nucle
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Zech, Veronika F. E., Margit Dlaska, Alexandar Tzankov, and Wolfgang Hilbe. "Prognostic and diagnostic relevance of hnRNP A2/B1, hnRNP B1 and S100 A2 in non-small cell lung cancer." Cancer Detection and Prevention 30, no. 5 (2006): 395–402. http://dx.doi.org/10.1016/j.cdp.2006.04.009.

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Dissertations / Theses on the topic "HnRNP A2/B1"

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Peebles, Katherine Anne. "HnRNP A2/B1 expression in neoplastic mouse lung cells /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Pharmaceutical Sciences) -- University of Colorado at Denver and Health Sciences Center, 2005.<br>Typescript. Includes bibliographical references (leaves 153-171). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
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Griffith, Brian Nelson. "Differential binding of hnRNP K, L and A2/B1 to an exonic splicing silencer element located within exon 12 of glucose-6-phosphate dehydrogenase mRNA." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4811.

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Thesis (Ph. D.)--West Virginia University, 2006.<br>Title from document title page. Document formatted into pages; contains xi, 183 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
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Nai-JhuDing and 丁乃筑. "Studying the role of hnRNP Q1 and hnRNP A2/B1 in Aurora-A translation." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/74480634540075209707.

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碩士<br>國立成功大學<br>生物資訊與訊息傳遞研究所<br>100<br>Aurora-A is a serine/threonine kinase that involved in centrosome maturation, mitotic entry, spindle assembly and chromosome segregation. Dysregulation of Aurora-A results in centrosome amplification, cytokinesis failure, aneuploidy, and finally leads to tumor formation. It was reported that Aurora-A is overexpressed in a lot of cancers. Our previously studies indicated that EGF can translational up-regulate the expression of Aurora-A through a specific 5’-untranslated region (5’UTR). In addition, hnRNP Q1 and hnRNP A2/B1 may participate the translational
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Leal, Graciano. "Regulation of hnRNP A2/B1 and hnRNP K by synaptic activity and BDNF in the hippocampus." Doctoral thesis, 2014. http://hdl.handle.net/10316/24128.

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Tese de doutoramento em Biociências, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra<br>Synaptic plasticity describes the process by which connections between neurons, or synapses, change in strength. By definition, it is a functional term referring to an increase or decrease in synaptic efficacy, which is accompanied by structural changes at synapses.Long-term potentiation (LTP) is the most studied form of synaptic plasticity and it has been widely recognized that synaptic changes that underpin certain forms of learning and memory may be similar to those involved i
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Wang, Hsin Ju, and 王馨茹. "Investigation of the role of NP in hnRNP A2/B1-mediated miRNA biogenesis." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/74580343168277538398.

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碩士<br>長庚大學<br>醫學生物技術暨檢驗學系<br>102<br>Influenza A virus infection frequently causes respiratory disease. Our research group observed that NP can interact directly with a glycine- rich motif of heterogeneous nuclear ribonucleoproteins (hnRNP A2/B1). In addition, NP and hnRNP A2/B1 colocalize in the nuclei of virus-infected cells early in the infection process. The RNA recognition motif of hnRNP A2/B1 exhibits greater than 80% similarity with hnRNP A1, which can modulate miRNA biogenesis. A previous study indicated that hnRNP A2/B1 can interact with the terminal loop of miR-7-1. Another research d
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Chang, Cheng Kai, and 張程凱. "Interaction of influenza viral nucleoprotein with hnRNP A2/B1 and its impacts on viral replication." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/484y48.

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博士<br>長庚大學<br>生物醫學研究所<br>106<br>Viral host interaction contributes to both viral replication and host defense mechanisms during infection. A cellular protein, heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1, was found to interact with influenza A virus NP protein by antibody precipitation assay and MALDI-TOF identification. The interaction was further confirmed by means of co-immunoprecipitation. In vitro binding assay using a series of truncated forms of hnRNP A2 recombinant proteins revealed that glycine-rich domain (GRD) in C-terminus of hnRNP A2 was responsible for the interaction. I
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Book chapters on the topic "HnRNP A2/B1"

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Tockman, Melvyn S., Tatyana A. Zhukov, Yener S. Erozan, William H. Westra, Jun Zhou, and James L. Mulshine. "Antigen Retrieval Improves hnRNP A2/B1 Immunohistochemical Localization in Premalignant Lesions of the Lung." In Clinical and Biological Basis of Lung Cancer Prevention. Birkhäuser Basel, 1998. http://dx.doi.org/10.1007/978-3-0348-8924-7_21.

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Conference papers on the topic "HnRNP A2/B1"

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Tauler, Jordi, Jessica Siegler, Xiaoguang Sun, Liliana Moreno-Vinasco, and Joe GN Garcia. "Abstract 352: hnRNP A2/B1 regulates S1PR3 expression in lung cancer." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-352.

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Fritsch, R., D. Eselboeck, B. Jahn-Schmid, et al. "FRI0086 Characterisation of ra33 (hnrnp-a2/b1)- autoreactive t cells in sle-patients." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.1228.

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Vasiljevic, J., C. Niehage, D. Vasiljevic та ін. "hnRNP A2/B1 as a novel post-transcriptional regulator of insulin expression in β-cells". У Diabetes Kongress 2018 – 53. Jahrestagung der DDG. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1641820.

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Sieghart, D., P. Studenic, M. Grundhuber, et al. "P006 ANTI-RA33 (HNRNP-A2/B1) autoantibodies are associated with the therapeutic response to methotrexate in patients with rheumatoid arthritis." In 38th European Workshop for Rheumatology Research, 22–24 February 2018, Geneva, Switzerland. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-ewrr2018.32.

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