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Journal articles on the topic 'HnRNPK'

Author: Grafiati

Published: 5 September 2021

Last updated: 29 July 2025

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1

Rothzerg, Emel, Wenyu Feng, Dezhi Song, et al. "Single-Cell Transcriptome Analysis Reveals Paraspeckles Expression in Osteosarcoma Tissues." Cancer Informatics 21 (January 2022): 117693512211401. http://dx.doi.org/10.1177/11769351221140101.

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Nuclear paraspeckles are subnuclear bodies contracted by nuclear-enriched abundant transcript 1 (NEAT1) long non-coding RNA, localised in the interchromatin space of mammalian cell nuclei. Paraspeckles have been critically involved in tumour progression, metastasis and chemoresistance. To this date, there are limited findings to suggest that paraspeckles, NEAT1 and heterogeneous nuclear ribonucleoproteins (hnRNPs) directly or indirectly play roles in osteosarcoma progression. Herein, we analysed NEAT1, paraspeckle proteins (SFPQ, PSPC1 and NONO) and hnRNP members (HNRNPK, HNRNPM, HNRNPR and HN

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Pettit Kneller, Elizabeth L., John H. Connor, and Douglas S. Lyles. "hnRNPs Relocalize to the Cytoplasm following Infection with Vesicular Stomatitis Virus." Journal of Virology 83, no. 2 (2008): 770–80. http://dx.doi.org/10.1128/jvi.01279-08.

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ABSTRACT Vesicular stomatitis virus (VSV) matrix protein inhibits nuclear-cytoplasmic mRNA transport. The goal of this work is to determine whether VSV inhibits the nuclear-cytoplasmic transport of heterogeneous ribonucleoproteins (hnRNPs), which are thought to serve as mRNA export factors. Confocal microscopy experiments showed that hnRNPA1, hnRNPK, and hnRNPC1/C2, but not hnRNPB1 or lamin A/C, are relocalized to the cytoplasm during VSV infection. We determined whether protein import is inhibited by VSV by transfecting cells with a plasmid encoding enhanced green fluorescent protein (EGFP) t

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3

Cloe, Adam, Li Chen, Yuan Li, Hongtao Liu, and Jason X. Cheng. "Identification of Specific Hnrnps As Novel Therapeutic Targets and Responsive Indicators of KPT330 (selinexor) in Leukemia." Blood 128, no. 22 (2016): 1657. http://dx.doi.org/10.1182/blood.v128.22.1657.1657.

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Abstract Background: Activenuclear-cytoplasmic shuttling of proteins and RNAs, such as heterogeneous ribonucleoproteins (hnRNPs), is essential for the normal function and survival of eukaryotic cells and tumorigenesis (Dreyfuss et al. 1993 Annu Rev Biochem 62, 289; Gorlich and Mattaj 1996 Science 271, 1513). Up-regulation of exportin 1 (XPO1)/chromosomal maintenance 1 (CRM1), a member of the karyopherin-β family of nuclear export receptor proteins, has been implicated in solid and hematologic malignancies (Kau Kau et al. 2004).Selinexor (KPT-330) has been shown to be able block in vitro and in

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Hornbaker, Marisa, Miguel Gallardo, Xiaorui Zhang, et al. "2180." Journal of Clinical and Translational Science 1, S1 (2017): 58. http://dx.doi.org/10.1017/cts.2017.207.

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OBJECTIVES/SPECIFIC AIMS: Acute myeloid leukemia (AML) is a devastating hematologic malignancy wherein <20% of patients will survive 5 years after diagnosis. In an effort to understand alterations that drive AML development and progression, The Cancer Genome Atlas detailed the most common recurrent mutations. One gene of interest identified here was HNRNPK, supporting our clinical observations that suggest altered expression levels of HNRNPK and its corresponding protein (hnRNP K) may impact AML. Here, we aim to elucidate the impact of hnRNP K overexpression in AML by utilizing AML cell lin

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Aguilar-Garrido, Pedro, Maria Velasco-Estevez, Miguel Ángel Navarro-Aguadero, et al. "Hnrnpk Overexpression Drives Nucleolar Aberrancies Causing Ribosomopathies." Blood 142, Supplement 1 (2023): 5659. http://dx.doi.org/10.1182/blood-2023-178022.

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Background: Protein biogenesis is a complex process involving nucleoli and ribosomes. Alterations in any step could lead to alterations in ribosome functionality and protein synthesis. Hnrnpk is an RNA-binding protein (RBP) involve in these processes, finding that an overexpression (OE) produces nucleus and nucleolar stress (NS), decreases transcription, and drives an imbalance in ribosome biogenesis, causing a reduced translation. Aims: To elucidate how hnRNP K dysregulation affects the hematopoietic stem cell (HSCs) biology. Methods: To study the impact of Hnrnpk OE in vivo, we developed an

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Hornbaker, Marisa J., Miguel Gallardo, Xiaorui Zhang, et al. "hnRNP K Overexpression Drives AML Progression By Altering Pathways Critical for Myeloid Proliferation and Differentiation." Blood 128, no. 22 (2016): 744. http://dx.doi.org/10.1182/blood.v128.22.744.744.

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Abstract Acute myeloid leukemia (AML) is a disease largely defined by recurrent genetic and chromosomal abnormalities. As such, The Cancer Genome Atlas' recent detailed examination of the most common genetic abnormalities that drive AML uncovered relatively few novel alterations. However, within this list of recurrently mutated genes was heterogeneous nuclear ribonucleoprotein K (HNRNPK). While previously unknown to impact AML, we recently identified HNRNPK as a haploinsufficient tumor suppressor at the 9q21.32 locus. In contrast to its tumor suppressive roles, hnRNP K is most customarily over

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Xu, Haixia, Jiahua Guo, Wei Wu, et al. "Deletion of Hnrnpk Gene Causes Infertility in Male Mice by Disrupting Spermatogenesis." Cells 11, no. 8 (2022): 1277. http://dx.doi.org/10.3390/cells11081277.

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HnRNPK is a heterogeneous nuclear ribonucleoprotein (hnRNP) that has been firmly implicated in transcriptional and post-transcriptional regulation. However, the molecular mechanisms by which hnRNPK orchestrates transcriptional or post-transcriptional regulation are not well understood due to early embryonic lethality in homozygous knockout mice, especially in a tissue-specific context. Strikingly, in this study, we demonstrated that hnRNPK is strongly expressed in the mouse testis and mainly localizes to the nucleus in spermatogonia, spermatocytes, and round spermatids, suggesting an important

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Post, Sean M., Kerstin Rhan, Shelley Herbrich та ін. "A Potential Link between hnRNP K and Cebpα: Implications for Ribosomal Dysfunction in Acute Myeloid Leukemia (AML)". Blood 142, Supplement 1 (2023): 4119. http://dx.doi.org/10.1182/blood-2023-190737.

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Deletion of the long arm of chromosome 9, del(9q), is a recurrent genetic abnormality involving the haploinsufficient loss of the RNA binding protein hnRNPK and is often associated with poor treatment responses in AML. In addition to reduced hnRNP K expression, other critical proteins, not localized to this locus, are also aberrantly expressed in del9q AML. One protein of critical interest is CEBPα, a well-established myeloid differentiation transcription factor. Recently, CEBPα was discovered to have a novel role in ribosomal RNA (rRNA) synthesis. However, as opposed to CEBPα, hnRNP K's role

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9

Le, Quang D., Amanda Lewis, Alice Dix-Matthews, et al. "Structural Characteristics and Properties of the RNA-Binding Protein hnRNPK at Multiple Physical States." International Journal of Molecular Sciences 26, no. 3 (2025): 1356. https://doi.org/10.3390/ijms26031356.

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Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA-binding protein containing low-complexity domains (LCDs), which are known to regulate protein behavior under stress conditions. This study demonstrates the ability to control hnRNPK’s transitions into four distinct material states—monomer, soluble aggregate, liquid droplet, and fibrillar hydrogel—by modulating environmental factors such as temperature and protein concentration. Importantly, the phase-separated and hydrogel states are newly identified for eGFP-hnRNPK, marking a significant advancement in understanding its material pro

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Rahn, Kerstin, Isabel Naarmann-de Vries, Yvonne Sackmann, et al. "Role of hnRNP K and Interacting mRNAs in Pathogenesis of AML with 9q Deletion." Blood 132, Supplement 1 (2018): 1531. http://dx.doi.org/10.1182/blood-2018-99-114699.

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Abstract Introduction: Acute myeloid leukemia (AML) is characterized by heterogeneous cytogenetic and molecular aberrations. Deletions on the long arm of chromosome 9 (del(9q)) are observed in 2% of AML patients. In about 24% of the cases, del(9q) is observed as sole karyotypic abnormality, while in the remaining 76%, it is associated with a t(8;21) translocation or other aberrations. Among all del(9q) AML cases, 36%-50% exhibit an additional t(8;21), whereas 7%-14% of AML cases with t(8;21) show del(9q) as an additional aberration. A commonly deleted region (CDR) of del(9q) was defined and fu

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Iwabuchi, Erina, Yasuhiro Miki, Takashi Suzuki, Hisashi Hirakawa, Takanori Ishida, and Hironobu Sasano. "Heterogeneous Nuclear Ribonucleoprotein K Is Involved in the Estrogen-Signaling Pathway in Breast Cancer." International Journal of Molecular Sciences 22, no. 5 (2021): 2581. http://dx.doi.org/10.3390/ijms22052581.

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Heterogeneous nuclear ribonucleoprotein K (hnRNPK) transcripts are abundant in estrogen receptor (ER)- or progesterone receptor (PR)-positive breast cancer. However, the biological functions of hnRNPK in the ER-mediated signaling pathway have remained largely unknown. Therefore, this study analyzes the functions of hnRNPK expression in the ER-mediated signaling pathway in breast cancer. We initially evaluated hnRNPK expression upon treatment with estradiol (E2) and ICI 182,780 in the ERα-positive breast carcinoma cell line MCF-7. The results revealed that E2 increased hnRNPK; however, hnRNPK e

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Iwabuchi, Erina, Yasuhiro Miki, Kiyoshi Ito, Takanori Ishida, and Hironobu Sasano. "Heterogeneous Nuclear Ribonucleoprotein K Is Involved in the Estrogen-Signaling Pathway." Journal of the Endocrine Society 5, Supplement_1 (2021): A1020—A1021. http://dx.doi.org/10.1210/jendso/bvab048.2088.

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Abstract Heterogeneous nuclear ribonucleoprotein K (hnRNPK) has been found in the nucleus, cytoplasm, and mitochondria. It is implicated in chromatin remodeling, transcription, splicing, and translation processes. Although hnRNPK has reportedly been associated with poor prognosis in colon cancer patients, it is beneficial in gastric cancer as it inhibits cancer cell proliferation. Expression of hnRNPK in ER (Estrogen receptor) -positive/PR (Progesterone receptor) -positive breast cancer was higher than other subtypes; however, the biological functions of hnRNPK in the ER-mediated signaling pat

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Chen, Chiao-Che, Jen-Hao Yang, Shu-Ling Fu, Wey-Jinq Lin, and Chao-Hsiung Lin. "Arginine Methylation of hnRNPK Inhibits the DDX3-hnRNPK Interaction to Play an Anti-Apoptosis Role in Osteosarcoma Cells." International Journal of Molecular Sciences 22, no. 18 (2021): 9764. http://dx.doi.org/10.3390/ijms22189764.

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Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA/DNA binding protein involved in diverse cell processes; it is also a p53 coregulator that initiates apoptosis under DNA damage conditions. However, the upregulation of hnRNPK is correlated with cancer transformation, progression, and migration, whereas the regulatory role of hnRNPK in cancer malignancy remains unclear. We previously showed that arginine methylation of hnRNPK attenuated the apoptosis of U2OS osteosarcoma cells under DNA damage conditions, whereas the replacement of endogenous hnRNPK with a methylation-defective mutant

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Yang, Jen-Hao, Yi-Ying Chiou, Shu-Ling Fu, et al. "Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation." Nucleic Acids Research 42, no. 15 (2014): 9908–24. http://dx.doi.org/10.1093/nar/gku705.

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Abstract Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA/DNA-binding protein involved in chromatin remodeling, RNA processing and the DNA damage response. In addition, increased hnRNPK expression has been associated with tumor development and progression. A variety of post-translational modifications of hnRNPK have been identified and shown to regulate hnRNPK function, including phosphorylation, ubiquitination, sumoylation and methylation. However, the functional significance of hnRNPK arginine methylation remains unclear. In the present study, we demonstrated that the methylation

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Hammam, Olfat, Mona Magdy, Amgad Anas, Ali Abdel Rahim, Mohamed Heedaya, and Ahmed Helmy. "Expression of hnRNPK & Claudin-4 in HCV-Induced Early HCC and Adjacent Liver Tissue." Open Access Macedonian Journal of Medical Sciences 5, no. 5 (2017): 595–602. http://dx.doi.org/10.3889/oamjms.2017.092.

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BACKGROUND: HCC in Egypt usually occurs in HCV cirrhotic livers with poor prognosis due to late diagnosis. High hnRNPK & low Claudin-4 profiles indicate Epithelial Mesenchymal Transition (EMT), malignant transformation and high-grade tumours.AIM: We studied the immunohistochemical expression of hnRNPK and Claudin-4 in HCV induced early HCC (eHCC) and adjacent liver tissue in Egyptian patients to improve eHCC detection in cirrhotic livers with better curative therapy options.METHOD: We studied the immunohistochemical expression of hnRNPK and Claudin-4 in 100 Egyptian patients resection spec

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Liu, Xiao-hui, Jie Ma, Jun-xia Feng, Yuan Feng, Yun-fang Zhang, and Lang-xia Liu. "Regulation and related mechanism of GSN mRNA level by hnRNPK in lung adenocarcinoma cells." Biological Chemistry 400, no. 7 (2019): 951–63. http://dx.doi.org/10.1515/hsz-2018-0417.

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Abstract Gelsolin (GSN) is an actin filament-capping protein that plays a key role in cell migration. Here we show that heterogeneous nuclear ribonucleoprotein K (hnRNPK) regulates GSN expression level by binding to the 3′-untranslated region (3′UTR) of GSN mRNA in non-small cell lung cancers (NSCLC) H1299 cells which are highly metastatic and express high level of GSN. We found that hnRNPK overexpression increased the mRNA and protein level of GSN, whereas hnRNPK knockdown by siRNA decreased the mRNA and protein level of GSN in both H1299 and A549 cells, indicating a positive role of hnRNPK i

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Pieterse, Lisa, Maranda McDonald, Rachy Abraham, and Diane E. Griffin. "Heterogeneous Ribonucleoprotein K Is a Host Regulatory Factor of Chikungunya Virus Replication in Astrocytes." Viruses 16, no. 12 (2024): 1918. https://doi.org/10.3390/v16121918.

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Chikungunya virus (CHIKV) is an emerging, mosquito-borne arthritic alphavirus increasingly associated with severe neurological sequelae and long-term morbidity. However, there is limited understanding of the crucial host components involved in CHIKV replicase assembly complex formation, and thus virus replication and virulence-determining factors, within the central nervous system (CNS). Furthermore, the majority of CHIKV CNS studies focus on neuronal infection, even though astrocytes represent the main cerebral target. Heterogeneous ribonucleoprotein K (hnRNP K), an RNA-binding protein involv

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Xu, Yongjie, Wei Wu, Qiu Han, et al. "Post-translational modification control of RNA-binding protein hnRNPK function." Open Biology 9, no. 3 (2019): 180239. http://dx.doi.org/10.1098/rsob.180239.

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Heterogeneous nuclear ribonucleoprotein K (hnRNPK), a ubiquitously occurring RNA-binding protein (RBP), can interact with numerous nucleic acids and various proteins and is involved in a number of cellular functions including transcription, translation, splicing, chromatin remodelling, etc. Through its abundant biological functions, hnRNPK has been implicated in cellular events including proliferation, differentiation, apoptosis, DNA damage repair and the stress and immune responses. Thus, it is critical to understand the mechanism of hnRNPK regulation and its downstream effects on cancer and

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Hitachi, Keisuke, Yuri Kiyofuji, Masashi Nakatani, and Kunihiro Tsuchida. "Myoparr-Associated and -Independent Multiple Roles of Heterogeneous Nuclear Ribonucleoprotein K during Skeletal Muscle Cell Differentiation." International Journal of Molecular Sciences 23, no. 1 (2021): 108. http://dx.doi.org/10.3390/ijms23010108.

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RNA-binding proteins (RBPs) regulate cell physiology via the formation of ribonucleic-protein complexes with coding and non-coding RNAs. RBPs have multiple functions in the same cells; however, the precise mechanism through which their pleiotropic functions are determined remains unknown. In this study, we revealed the multiple inhibitory functions of heterogeneous nuclear ribonucleoprotein K (hnRNPK) for myogenic differentiation. We first identified hnRNPK as a lncRNA Myoparr binding protein. Gain- and loss-of-function experiments showed that hnRNPK repressed the expression of myogenin at the

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Xu, Lipei, Tingting Zhang, Wensi Huang, et al. "YAP mediates the positive regulation of hnRNPK on the lung adenocarcinoma H1299 cell growth." Acta Biochimica et Biophysica Sinica 51, no. 7 (2019): 677–87. http://dx.doi.org/10.1093/abbs/gmz053.

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AbstractLung cancer is the leading cause of cancer death worldwide, and non-small cell lung cancer (NSCLC) accounts for 80%–85% of diagnostic cases. The molecular mechanisms of NSCLC pathogenesis are not well understood. Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is a multifunctional protein that regulates gene expression and signal transduction and closely associated with tumorigenesis, but its mechanism of action in the pathogenesis of NSCLC is unclear. In this study, we observed that the expression pattern of hnRNPK in H1299 lung adenocarcinoma cells varied depending on the cell den

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Xiaoli, Liu, Hongqian Zhu, Song Zhang, et al. "Preliminary Functional Studies of hnRNPK in Progression of CML." Blood 112, no. 11 (2008): 4229. http://dx.doi.org/10.1182/blood.v112.11.4229.4229.

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Abstract The blast crisis(BC) is terminal phase of chronic myeloid leukemia (CML), which is accompanied by an increase in both BCR/ABL mRNA and protein level and imatinib(IM) resistance. The BCR/ABL oncoprotein is responsible for inducing and sustaining the leukemic phenotype through its deregulated tyrosine kinase activity which is essential for recruitment and induction of signaling pathways leading to cytokine-independent proliferation, resistance to apoptosis, and impaired differentiation of BCR/ABL-expressing myeloid and lymphoid progenitors. However, the molecular mechanisms responsible

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Dolnik, Anna, Sundaram R. Chakkarappan, Tamara J. Blätte, et al. "Mutational Landscape of Del(9q) Acute Myeloid Leukemia (AML)." Blood 126, no. 23 (2015): 3844. http://dx.doi.org/10.1182/blood.v126.23.3844.3844.

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Abstract Background: Deletion of the long arm of chromosome 9, del(9q), is a recurrent genomic abnormality, which occurs at a frequency of ~2% in AML. Interestingly, deletions of 9q are mainly found in t(8;21)-positive AML, as well as in AML with NPM1 (NPM1mut) or CEBPA (CEBPAmut) gene mutation, thereby suggesting that del(9q) can act as cooperating event in these prognostically favorable AML subgroups. Aims: In order to dissect the biology of AML with del(9q), we comprehensively characterized a large cohort of 9q21 deleted cases (n=45) at the molecular level. Methods: We performed SNP 6.0 mic

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Gallardo, Miguel, Hun Ju Lee, Xiaorui Zhang, et al. "hnRNP K Is a Novel Haploinsufficient Tumor Suppressor at the 9q21.32 Locus That Defines a Subset of AML." Blood 126, no. 23 (2015): 439. http://dx.doi.org/10.1182/blood.v126.23.439.439.

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Abstract Deletion of the 9q21.32 locus is observed in some patients with AML, suggesting an undescribed tumor suppressor resides in this region. HNRNPK is an attractive candidate, as it is one of six genes mapped to this region and is thought to drive AML progression when mutated. Mechanistically, hnRNP K functions as a DNA and RNA binding protein that transcriptionally and translationally governs gene expression. Together, these findings suggest hnRNP K may serve as a currently uncharacterized tumor suppressor and that its haploinsufficiency plays a pivotal role in AML progression. To interro

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Naarmann-de Vries, Isabel S., Roberta Senatore, Bodo Moritz, et al. "Methylated HNRNPK acts on RPS19 to regulate ALOX15 synthesis in erythropoiesis." Nucleic Acids Research 49, no. 6 (2021): 3507–23. http://dx.doi.org/10.1093/nar/gkab116.

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Abstract Post-transcriptional control is essential to safeguard structural and metabolic changes in enucleated reticulocytes during their terminal maturation to functional erythrocytes. The timely synthesis of arachidonate 15-lipoxygenase (ALOX15), which initiates mitochondria degradation at the final stage of reticulocyte maturation is regulated by the multifunctional protein HNRNPK. It constitutes a silencing complex at the ALOX15 mRNA 3′ untranslated region that inhibits translation initiation at the AUG by impeding the joining of ribosomal 60S subunits to 40S subunits. To elucidate how HNR

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Val, S., S. Jeong, M. Poley, et al. "MP5: STABLE ISOTOPE LABELED BY AMINO ACID IN CULTURE (SILAC) STRATEGY TO ANALYZE HUMAN MIDDLE EAR EPITHELIAL CELLS (HMEEC) SECRETOME IN RESPONSE TO NTHI LYSATES: EVIDENCE OF THE IMPLICATION OF EXOSOMES IN OTITIS MEDIA." Journal of Investigative Medicine 64, no. 3 (2016): 806.2–806. http://dx.doi.org/10.1136/jim-2016-000080.17.

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Purpose of StudyThis study aimed at characterizing the secretome of HMEEC-1 and to evaluate its regulation in response to NTHi lysates and better understand the pathogenesis of Otitis Media (OM).Methods UsedHMEEC-1 were labeled with heavy isotopes of arginine and lysine to obtain a spike-in standard that was mixed with the conditions of interest (control or treated 24 hrs, secretions recovered 24 hrs or 48 hrs) and separated by SDS-PAGE. Peptides generated by in-gel digestion were analyzed by LC-MS/MS. Middle ear effusions (MEEs) from patients having chronic OM were analyzed to validate the re

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Hornbaker, Marisa J., Prerna Malaney, Xiaorui Zhang, et al. "hnRNP K Overexpression Drives Myeloid Malignancy Via Interaction with RUNX1." Blood 132, Supplement 1 (2018): 2622. http://dx.doi.org/10.1182/blood-2018-99-117387.

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Abstract Acute myeloid leukemia (AML) is a conglomerate of hematologic malignancies characterized by recurrent genetic and/or chromosomal aberrations. Recent development of targeted agents has bolstered our armamentarium of therapeutic options and improved outcomes for many patients. Acquiring deeper mechanistic understanding of myeloid leukemogenesis will provide a basis for development of even more therapeutic strategies and further improve patient outcomes. Our clinical data have revealed that overexpression of HNRNPK is a recurrent abnormality that occurs in upwards of 20% of AML cases at

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Gallardo, Miguel, Hun Ju Lee, Xiaorui Zhang, et al. "hnRNP K: A Novel Regulator of Hematopoiesis and A Potential Predictive Biomarker In Acute Myeloid Leukemia." Blood 122, no. 21 (2013): 226. http://dx.doi.org/10.1182/blood.v122.21.226.226.

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Abstract In acute myeloid leukemia (AML), numerous genetic and epigenetic changes have been identified that result in loss of differentiation, apoptosis, and cell cycle arrest. In contrast, changes in protein expression are not as well characterized. To address these deficiencies, we performed RPPA analysis on 415 de novo AML patient samples and identified increased expression of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a predictor of poor outcome. These elevated hnRNP K levels were most predictive in AML patients who also harbored mutant NPM1 and wild type FLT3. While NPM1MUT/FL

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Nakamoto, Meagan Y., Nickolaus C. Lammer, Robert T. Batey, and Deborah S. Wuttke. "hnRNPK recognition of the B motif of Xist and other biological RNAs." Nucleic Acids Research 48, no. 16 (2020): 9320–35. http://dx.doi.org/10.1093/nar/gkaa677.

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Abstract Heterogeneous nuclear ribonuclear protein K (hnRNPK) is an abundant RNA-binding protein crucial for a wide variety of biological processes. While its binding preference for multi-cytosine-patch (C-patch) containing RNA is well documented, examination of binding to known cellular targets that contain C-patches reveals an unexpected breadth of binding affinities. Analysis of in-cell crosslinking data reinforces the notion that simple C-patch preference is not fully predictive of hnRNPK localization within transcripts. The individual RNA-binding domains of hnRNPK work together to interac

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Xu, Yongjie, Wei Wu, Qiu Han, et al. "New Insights into the Interplay between Non-Coding RNAs and RNA-Binding Protein HnRNPK in Regulating Cellular Functions." Cells 8, no. 1 (2019): 62. http://dx.doi.org/10.3390/cells8010062.

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The emerging data indicates that non-coding RNAs (ncRNAs) epresent more than the “junk sequences” of the genome. Both miRNAs and long non-coding RNAs (lncRNAs) are involved in fundamental biological processes, and their deregulation may lead to oncogenesis and other diseases. As an important RNA-binding protein (RBP), heterogeneous nuclear ribonucleoprotein K (hnRNPK) is known to regulate gene expression through the RNA-binding domain involved in various pathways, such as transcription, splicing, and translation. HnRNPK is a highly conserved gene that is abundantly expressed in mammalian cells

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Wang, Ningling, Ping Zhang, Xuejiang Guo, Zuomin Zhou, and Jiahao Sha. "Hnrnpk, a Protein Differentially Expressed in Immature Rat Ovarian Development, Is Required for Normal Primordial Follicle Assembly and Development." Endocrinology 152, no. 3 (2011): 1024–35. http://dx.doi.org/10.1210/en.2010-0797.

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The formation of ovarian follicles and subsequent development after birth are critical processes for female reproduction, and inappropriate coordination of these processes contributes to ovarian pathologies, such as premature ovarian failure and infertility. Identification and functional investigation of the factors involved in follicular assembly and the initial recruitment will be of great significance to the understanding of the female reproduction process. In this study, we examined the roles of transcription factor heterogeneous nuclear ribonucleoprotein K (Hnrnpk) in rat primordial folli

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Zhou, Wei, Ying Liu, Honglian Li, Zhaoyu Song, Ying Ma, and Yu Zhu. "Mass Spectrometry and Computer Simulation Predict the Interactions of AGPS and HNRNPK in Glioma." BioMed Research International 2021 (September 28, 2021): 1–14. http://dx.doi.org/10.1155/2021/6181936.

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Ether lipids are overexpressed in malignant tumor and play an important role in tumor process. Glioma is the most common malignant central nervous system tumor, and the content of ether lipids is higher than that of normal tissues. Alkylglycerone phosphate synthase (AGPS) is a key enzyme in the synthesis of ether esters and plays a vital role in maintaining the morphology and pathogenic properties of tumor cells. The cell proliferation and the content of tumor-related lipid such as monoalkylglycerol ether (MAGe), lysophosphatidic acid ether (LPAe), lysophosphatidylcholine ether (LPCe), lysopho

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STAINS, Joseph P., Fernando LECANDA, Dwight A. TOWLER, and Roberto CIVITELLI. "Heterogeneous nuclear ribonucleoprotein K represses transcription from a cytosine/thymidine-rich element in the osteocalcin promoter." Biochemical Journal 385, no. 2 (2005): 613–23. http://dx.doi.org/10.1042/bj20040680.

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HnRNP K (heterogeneous nuclear ribonucleoprotein K) was biochemically purified from a screen of proteins co-purifying with binding activity to the osteocalcin promoter. We identify hnRNP K as a novel repressor of osteocalcin gene transcription. Overexpression of hnRNP K lowers the expression of osteocalcin mRNA by 5-fold. Furthermore, luciferase reporter assays demonstrate that overexpression of hnRNP K represses osteocalcin transcription from a CT (cytosine/thymidine)-rich element in the proximal promoter. Electrophoretic mobility-shift analysis reveals that recombinant hnRNP K binds to the C

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Leopoldino, Andréia M., Fernanda Carregaro, Carlos H. T. P. Silva, et al. "Sequence and transcriptional study of HNRPK pseudogenes, and expression and molecular modeling analysis of hnRNP K isoforms." Genome 50, no. 5 (2007): 451–62. http://dx.doi.org/10.1139/g07-016.

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The heterogeneous nuclear ribonucleoproteins (hnRNPs) comprise a large family of proteins that play important roles in telomere biogenesis, DNA repair, cellular signaling, and the regulation of expression at both the transcriptional and translational levels. One of the most extensively studied hnRNP family members, hnRNP K, has been implicated in a variety of processes, including chromatin remodeling, transcription, splicing, and translation events. In this study, we analyzed processed HNRPK pseudogenes (HNRPK ψ1–ψ4) and coding sequences. HNRPK pseudogenes are apparently nonfunctional, and ψ1

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Ostareck-Lederer, Antje, Dirk H. Ostareck, Christophe Cans, et al. "c-Src-Mediated Phosphorylation of hnRNP K Drives Translational Activation of Specifically Silenced mRNAs." Molecular and Cellular Biology 22, no. 13 (2002): 4535–43. http://dx.doi.org/10.1128/mcb.22.13.4535-4543.2002.

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ABSTRACT hnRNPK and hnRNP E1/E2 mediate translational silencing of cellular and viral mRNAs in a differentiation-dependent way by binding to specific regulatory sequences. The translation of 15-lipoxygenase (LOX) mRNA in erythroid precursor cells and of the L2 mRNA of human papilloma virus type 16 (HPV-16) in squamous epithelial cells is silenced when either of these cells is immature and is activated in maturing cells by unknown mechanisms. Here we address the question of how the silenced mRNA can be translationally activated. We show that hnRNP K and the c-Src kinase specifically interact wi

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Santos, Sara Costa, Lucas De Sousa Pontes, Maria Elisabete Amaral De Moraes, and Caroline De Fátima Aquino Moreira-Nunes. "Identificação de alterações genéticas relacionadas à síndrome do X frágil e ao transtorno de espectro do autismo por meio de ferramentas de bioinformática." Revista de Ciências Médicas e Biológicas 19, no. 2 (2020): 292. http://dx.doi.org/10.9771/cmbio.v19i2.34910.

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<p><strong>Introdução</strong>: a Síndrome do X Frágil (FXS) é a forma mais prevalente de deficiência intelectual herdável, e é a principal causa monogênica<br />para o desenvolvimento de Transtorno de Espectro do Autismo (TEA). <strong>Objetivo</strong>: o objetivo do presente estudo é identificar RNAm<br />associados à possíveis vias neurocomportamentais na SFX como no TEA, através de ferramentas de bioinformática. <strong>Metodologia</strong>:<br />para identificação de possíveis vias alteradas entre a SFX e pacientes com TEA, util

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Wang, Ziyi, Heng Qiu, Jianbo He, et al. "The emerging roles of hnRNPK." Journal of Cellular Physiology 235, no. 3 (2019): 1995–2008. http://dx.doi.org/10.1002/jcp.29186.

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Cao, Yun, Wei Zhang, Yi-Ting Jin, and Qiang Zou. "Mining the Prognostic Value of HNRNPAB and Its Function in Breast Carcinoma." International Journal of Genomics 2020 (May 14, 2020): 1–17. http://dx.doi.org/10.1155/2020/3750673.

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Heterogeneous nuclear ribonucleoproteins (HNRNPs) are crucial members in the pathogenesis and progression of numerous cancers. However, the expression pattern and clinical significance of HNRNPs in breast carcinoma (BC) remain to be investigated. In the present study, bioinformatic analysis identified HNRNPAB as the only commonly upregulated HNRNP in BC. Elevated expression of HNRNPAB was positively associated with more aggressive diseases and poorer survival rates in BC. Pathway analysis revealed that HNRNPAB coexpressed genes were enriched in the pathway of G2/M phase transition, and the exp

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Su, Zhan, Xin Liu, Yan Xu, et al. "Novel Fusion Genes Involving Hnrnpc and Rarg in Acute Myeloid Leukemia Mimicking Acute Promyelocytic Leukemia." Blood 132, Supplement 1 (2018): 5274. http://dx.doi.org/10.1182/blood-2018-99-111433.

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Abstract The roles of Heterogeneous nuclear ribonucleoproteins(hnRNPs) in regulating tumor development and progression, either as oncogenes or as tumor suppressors, were well documented. HnRNP C is one of the members of hnRNPs,and differential expression of hnRNP C has been found in series of tumor cells. However, the role of hnRNP C in leukemia has not been reported to date. Here, we report the first novel gene fusion event between HNRNPC and retinoic acid receptor gamma (RARG) in acute myeloid leukemia mimicking acute promyelocytic leukemia. This translocation produced the HNRNPC-RARG fusion

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Blasius, Melanie, and Jiri Bartek. "ATM targets hnRNPK to control p53." Cell Cycle 12, no. 8 (2013): 1162. http://dx.doi.org/10.4161/cc.24485.

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Malaney, Prerna, Marisa Hornbaker, Miguel Gallardo, et al. "hnRNPK as a Driver of Lymphomagenesis." Clinical Lymphoma Myeloma and Leukemia 17 (September 2017): S374—S375. http://dx.doi.org/10.1016/j.clml.2017.07.215.

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Harley, Jasmine, and Rickie Patani. "Stress-Specific Spatiotemporal Responses of RNA-Binding Proteins in Human Stem Cell-Derived Motor Neurons." International Journal of Molecular Sciences 21, no. 21 (2020): 8346. http://dx.doi.org/10.3390/ijms21218346.

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RNA-binding proteins (RBPs) have been shown to play a key role in the pathogenesis of a variety of neurodegenerative disorders. Amyotrophic lateral sclerosis (ALS) is an exemplar neurodegenerative disease characterised by rapid progression and relatively selective motor neuron loss. Nuclear-to-cytoplasmic mislocalisation and accumulation of RBPs have been identified as a pathological hallmark of the disease, yet the spatiotemporal responses of RBPs to different extrinsic stressors in human neurons remain incompletely understood. Here, we used healthy induced pluripotent stem cell (iPSC)-derive

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Zhang, Lin, Jiangfeng Li, Changfu Hao, et al. "Correction: Up-regulation of exosomal miR-125a in pneumoconiosis inhibits lung cancer development by suppressing expressions of EZH2 and hnRNPK." RSC Advances 8, no. 61 (2018): 34838. http://dx.doi.org/10.1039/c8ra90078g.

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Correction for ‘Up-regulation of exosomal miR-125a in pneumoconiosis inhibits lung cancer development by suppressing expressions of EZH2 and hnRNPK’ by Lin Zhang et al., RSC Adv., 2018, 8, 26538–26548.

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Gallardo, Miguel, Prerna Malaney, Marisa J. L. Aitken, et al. "Uncovering the Role of RNA-Binding Protein hnRNP K in B-Cell Lymphomas." JNCI: Journal of the National Cancer Institute 112, no. 1 (2019): 95–106. http://dx.doi.org/10.1093/jnci/djz078.

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Abstract Background Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an RNA-binding protein that is aberrantly expressed in cancers. We and others have previously shown that reduced hnRNP K expression downmodulates tumor-suppressive programs. However, overexpression of hnRNP K is the more commonly observed clinical phenomenon, yet its functional consequences and clinical significance remain unknown. Methods Clinical implications of hnRNP K overexpression were examined through immunohistochemistry on samples from patients with diffuse large B-cell lymphoma who did not harbor MYC alteratio

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Hu, Yuanlang, Tao Hao, Hanwen Yu, et al. "lhCLIP reveals the in vivo RNA–RNA interactions recognized by hnRNPK." PLOS Genetics 19, no. 10 (2023): e1011006. http://dx.doi.org/10.1371/journal.pgen.1011006.

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RNA-RNA interactions play a crucial role in regulating gene expression and various biological processes, but identifying these interactions on a transcriptomic scale remains a challenge. To address this, we have developed a new biochemical technique called pCp-biotin labelled RNA hybrid and ultraviolet crosslinking and immunoprecipitation (lhCLIP) that enables the transcriptome-wide identification of intra- and intermolecular RNA-RNA interactions mediated by a specific RNA-binding protein (RBP). Using lhCLIP, we have uncovered a diverse landscape of intermolecular RNA interactions recognized b

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Garrido, Pedro Aguilar, Maria Velasco Estevez, Miguel Ángel Navarro Aguadero, et al. "S179: HNRNPK OVEREXPRESSION DRIVES NUCLEOLAR ABERRANCIES CAUSING RIBOSOMPATHIES." HemaSphere 7 (August 2023): e8819188. http://dx.doi.org/10.1097/01.hs9.0000967628.88191.88.

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Komuro, Riho, Yuka Honda, Motoaki Yanaizu, Masami Nagahama, and Yoshihiro Kino. "Alzheimer’s Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins." Cells 12, no. 4 (2023): 602. http://dx.doi.org/10.3390/cells12040602.

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Genetic variations of CD33 have been implicated as a susceptibility factor of Alzheimer’s disease (AD). A polymorphism on exon 2 of CD33, rs12459419, affects the alternative splicing of this exon. The minor allele is associated with a reduced risk of AD and promotes the skipping of exon 2 to produce a shorter CD33 isoform lacking the extracellular ligand-binding domain, leading to decreased suppressive signaling on microglial activity. Therefore, factors that regulate the splicing of exon 2 may alter the disease-associated properties of CD33. Herein, we sought to identify the regulatory protei

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Puvvula, Pavan Kumar, Stephanie Buczkowski, and Anne M. Moon. "hnRNPK-derived cell-penetrating peptide inhibits cancer cell survival." Molecular Therapy - Oncolytics 23 (December 2021): 342–54. http://dx.doi.org/10.1016/j.omto.2021.10.004.

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Wang, Ke, Ying Hu, Jiangjiang Nie, Qinghua Zeng, Yu Hu, and Huansheng Wu. "Chicken hnRNPK suppresses interferon production, thereby enhancing IBDV replication." Research in Veterinary Science 184 (March 2025): 105527. https://doi.org/10.1016/j.rvsc.2025.105527.

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Post, Sean M., Prerna Malaney, Lauren Chan, et al. "Targeting the Oncogenic Functions of an RNA-Binding Protein Involved in Hematologic Malignancies." Blood 138, Supplement 1 (2021): 2226. http://dx.doi.org/10.1182/blood-2021-154072.

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Abstract hnRNP K (heterogeneous ribonucleoprotein K) is an RNA-binding protein that binds to conserved poly-C rich tracks in RNA and influences a diverse set of molecular pathways involved in tumorigenesis. Our previous studies identified hnRNP K overexpression in patients with diffuse large B-cell lymphoma (46/75, 61%) and acute myeloid leukemia (45/160, 28%). This overexpression correlates with dismal clinical outcomes and a lack of therapeutic responses to standard treatment. To explore hnRNP K's in vivo functions, we generated Hnrnpk-transgenic mouse models. These mice develop lymphoma phe

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Qiao, Lu, Ning Xie, Yuru Bai, et al. "Identification of Upregulated HNRNPs Associated with Poor Prognosis in Pancreatic Cancer." BioMed Research International 2019 (July 4, 2019): 1–11. http://dx.doi.org/10.1155/2019/5134050.

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Heterogeneous nuclear ribonucleoproteins (HNRNPs) are reported to play a crucial role in the pathogenic process of multiple malignancies. However, the expression patterns and prognostic values of HNRNPs in pancreatic cancer (PC) are lacking. In this study, several public databases were explored to identify the commonly upregulated HNRNPs in PC. The clinical significance of HNRNPL (heterogeneous nuclear ribonucleoproteins L) in PC was analyzed. We further performed a series of experiments to elucidate the biological functions of HNRNPL. Bioinformatics analysis including pathway enrichment and i

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