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Journal articles on the topic 'HNSC CANCER TREATMENT'

Author: Grafiati

Published: 16 January 2024

Last updated: 31 July 2025

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1

Agee, Robert, Samuel Flashner, Masataka Shimonosono, Andres Klein-Szanto, and Hiroshi Nakagawa. "Abstract 3082: Leveraging 3D organoids to identify molecular changes underlying HNSC initiation and development." Cancer Research 82, no. 12_Supplement (2022): 3082. http://dx.doi.org/10.1158/1538-7445.am2022-3082.

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Abstract Head and neck squamous cell carcinoma (HNSC) is a devastating disease accounting for 570,000 newly diagnosed cases and resulting in 344,000 deaths annually. HNSC arises from its histological precursor lesion, squamous dysplasia (HNSD); however, most patients are diagnosed with late-stage HNSC with no prior identification of pre-malignant disease. Earlier diagnosis and intervention could ameliorate the outsized burden of HNSC; therefore, there is an urgent unmet need to characterize the molecular changes underlying progression through HNSD to HNSC. To identify novel therapeutic targets

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2

Zhao, Yixuan, Xin Huang, Zewei Zhang, Haizhou Li, and Tao Zan. "The Long Noncoding Transcript HNSCAT1 Activates KRT80 and Triggers Therapeutic Efficacy in Head and Neck Squamous Cell Carcinoma." Oxidative Medicine and Cellular Longevity 2022 (August 4, 2022): 1–19. http://dx.doi.org/10.1155/2022/4156966.

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Head and neck squamous carcinoma (HNSC) is the most prevalent malignancy of the head and neck regions. Long noncoding RNAs (lncRNAs) are vital in tumorigenesis regulation. However, the role of lncRNAs in HNSC requires further exploration. Herein, through bioinformatic assays using The Cancer Genome Atlas (TCGA) datasets, rapid amplification of cDNA ends (RACE) assays, and RNA-FISH, we revealed that a novel cytoplasmic transcript, HNSC-associated transcript 1 (HNSCAT1, previously recognized as linc01269), was downregulated in tumor samples and advanced tumor stages and was also associated with

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Burkart, Sebastian, Christopher Weusthof, Karam Khorani, et al. "A Novel Subgroup of UCHL1-Related Cancers Is Associated with Genomic Instability and Sensitivity to DNA-Damaging Treatment." Cancers 15, no. 6 (2023): 1655. http://dx.doi.org/10.3390/cancers15061655.

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Purpose: Identification of molecularly-defined cancer subgroups and targeting tumor-specific vulnerabilities have a strong potential to improve treatment response and patient outcomes but remain an unmet challenge of high clinical relevance, especially in head and neck squamous cell carcinoma (HNSC). Experimental design: We established a UCHL1-related gene set to identify and molecularly characterize a UCHL1-related subgroup within TCGA-HNSC by integrative analysis of multi-omics data. An extreme gradient boosting model was trained on TCGA-HNSC based on GSVA scores for gene sets of the MSigDB

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Haarmann, Mareike S., Philipp Zimmermann, Malte Suchan, Dominik Funken, Jens Peter Klußmann, and Johannes Brägelmann. "Abstract 3928: Analyzing treatment effects of chemo- and immunotherapy in the context of the TME in an ex vivo model of HNSC." Cancer Research 85, no. 8_Supplement_1 (2025): 3928. https://doi.org/10.1158/1538-7445.am2025-3928.

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Abstract Head and neck squamous cell carcinoma (HNSC) accounts for 450.000 deaths worldwide each year. Rising cases of HNSC have been predicted. Understanding the tumor biology in patients is crucial to developing more efficient treatment strategies against HNSC. Especially in the context of immunotherapy, the interplay of immune, cancer and stroma cells in the tumor microenvironment (TME) strongly influences the biological characteristics and behavior of the tumor and its response to therapy. However, most HNSC in vitro models such as patient-derived cell lines and organoids do not recapitula

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Tang, Shouyi, Li Zhao, Xing-Bo Wu, et al. "Identification of a Novel Cuproptosis-Related Gene Signature for Prognostic Implication in Head and Neck Squamous Carcinomas." Cancers 14, no. 16 (2022): 3986. http://dx.doi.org/10.3390/cancers14163986.

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Head and neck squamous carcinoma (HNSC) is a frequent and deadly malignancy that is challenging to manage. The existing treatment options have considerable efficacy limitations. Hence, the identification of new therapeutic targets and the development of efficacious treatments are urgent needs. Cuproptosis, a non-apoptotic programmed cell death caused by excess copper, has only very recently been discovered. The present study investigated the prognostic importance of genes involved in cuproptosis through the mRNA expression data and related clinical information of HNSC patients downloaded from

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6

Cho, Sang Yeon, and Nam Sook Kang. "The Solute Carrier (SLC) Transporter Superfamily as Therapeutic Targets for the Treatment of Head and Neck Squamous Cell Carcinoma." Cancers 16, no. 18 (2024): 3226. http://dx.doi.org/10.3390/cancers16183226.

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Background: Head and neck squamous cell carcinoma (HNSC) is the most prevalent cancer in the head and neck region, originating from the mucosal epithelium of the oral cavity, pharynx, and larynx. The solute carrier (SLC) transporter superfamily, consisting of over 400 proteins across 65 families, plays a crucial role in cellular functions and presents promising targets in precision oncology. This study aims to analyze the expression of SLC transporters in HNSC and their potential as biomarkers and therapeutic targets. Methods: We leveraged mRNA and protein expression data from The Cancer Genom

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Pradhan, Sultan, and Arsheed Hussain Hakeem. "Management of Head and Neck Cancer: Surgical and Nonsurgical." An International Journal of Otorhinolaryngology Clinics 2, no. 1 (2010): 77–85. http://dx.doi.org/10.5005/jp-journals-10003-1020.

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Abstract It is right time to review the management of head and neck squamous cancer (HNSC) because of fundamental changes in both diagnostic and therapeutic modalities. Head and neck cancer affects area highly associated with the individual's. identity and can produce profound alteration in appearance, speech, and swallowing. Due to morbidity, disfigurement and problems of disease control clinicians used to have lot of reservations in treating complex HNSC cases. The field has taken a new vigor by incorporating important basic advances in understanding of cancer, new modalities of treatment an

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8

Chen, Yin-Ju, Joseph T. Chang, Guo-Rung You, Chun-Yu Huang, Kang-Hsing Fan, and Ann-Joy Cheng. "Panel biomarkers associated with cancer invasion and prognostic prediction for head–neck cancer." Biomarkers in Medicine 15, no. 11 (2021): 861–77. http://dx.doi.org/10.2217/bmm-2021-0213.

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Aim: Cell invasion leading to metastasis is a major cause of treatment failure in head–neck cancers (HNCs). Identifying prognostic molecules associated with invasiveness is imperative for clinical applications. Materials & methods: A systemic approach was used to globally survey invasion-related genes, including transcriptomic profiling, pathway analysis, data mining and prognostic assessment using TCGA-HNSC dataset. Results: Six functional pathways and six hub molecules (LAMA3, LAMC2, THBS1, IGF1R, PDGFB and TGFβ1) were identified that significantly contributed to cell invasion, leading t

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9

Park, Jun-Ook, Young Min Park, Woo-Jin Jeong, et al. "Survival Benefits From Surgery for Stage IVa Head and Neck Squamous Cell Carcinoma: A Multi-Institutional Analysis of 1,033 Cases." Clinical and Experimental Otorhinolaryngology 14, no. 2 (2021): 225–34. http://dx.doi.org/10.21053/ceo.2020.01732.

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Objectives. Head and neck squamous cell carcinomas (HNSCs) are frequently diagnosed at the locoregional advanced stage (stage IVa), but controversy remains regarding whether stage IVa HSNCs should be treated with upfront surgery or definitive chemoradiation therapy (CRT). The purpose of this study was to compare overall survival (OS) and disease-free survival (DFS) in patients with stage IVa HNSC treated primarily by surgery with curative intent with/without (neo)adjuvant treatment (surgery group) versus those treated primarily with CRT (CRT group).Methods. We reviewed data of 1,033 patients w

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10

Chuang, Yi-Hsuan, Chun-Yu Lin, Jih-Chin Lee, et al. "Identification of the HNSC88 Molecular Signature for Predicting Subtypes of Head and Neck Cancer." International Journal of Molecular Sciences 24, no. 17 (2023): 13068. http://dx.doi.org/10.3390/ijms241713068.

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Head and neck squamous cell carcinoma (HNSC) exhibits genetic heterogeneity in etiologies, tumor sites, and biological processes, which significantly impact therapeutic strategies and prognosis. While the influence of human papillomavirus on clinical outcomes is established, the molecular subtypes determining additional treatment options for HNSC remain unclear and inconsistent. This study aims to identify distinct HNSC molecular subtypes to enhance diagnosis and prognosis accuracy. In this study, we collected three HNSC microarrays (n = 306) from the Gene Expression Omnibus (GEO), and HNSC RN

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11

Xu, Chengbo, Hongfang Xu, and Baimei Liu. "Head and neck squamous cell carcinoma-specific prognostic signature and drug sensitive subtypes based on programmed cell death-related genes." PeerJ 11 (November 21, 2023): e16364. http://dx.doi.org/10.7717/peerj.16364.

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Background As a complex group of malignancies, head and neck squamous cell carcinoma (HNSC) is one of the leading causes of cancer mortality. This study aims to establish a reliable clinical classification and gene signature for HNSC prognostic prediction and precision treatments. Methods A consensus clustering analysis was performed to group HNSC patients in The Cancer Genome Atlas (TCGA) database based on genes linked to programmed cell death (PCD). Differentially expressed genes (DEGs) between subtypes were identified using the “limma” R package. The TCGA prognostic signature and PCD-relate

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12

Hill, James H., Randall L. Plant, David M. Harris, and Randal C. Paniello. "Photodynamic Therapy for Head and Neck Cancer Xenografts in Athymic Mice." Otolaryngology–Head and Neck Surgery 95, no. 5 (1986): 602–6. http://dx.doi.org/10.1177/019459988609500515.

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This study examines efficacy and optimal treatment variables of photodynamic therapy (PDT) for human head and neck squamous cancer (HNSC) xenografts in athymic mice. Two and four days after injection of hematoporphyrin derivative (HPD), tumors were illuminated with red light from an argon-dye laser. Sixty-three tumors were treated. With HPD dose and light intensity constant at 7.5 mg/kg and 100 mW/cm2, respectively, the extent of tumor necrosis was strongly dependent on duration of light exposure. There was no substantial difference in results for 30- and 60-minute treatment durations between

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13

Fekete, János Tibor, Ágnes Welker, and Balázs Győrffy. "miRNA Expression Signatures of Therapy Response in Squamous Cell Carcinomas." Cancers 13, no. 1 (2020): 63. http://dx.doi.org/10.3390/cancers13010063.

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Introduction: Squamous cell carcinomas (SCC) are a major subgroup of malignant tumors with a platinum-based first-line systematic chemotherapy. miRNAs play a role in various diseases and modulate therapy response as well. The aim of this study was to identify predictive miRNAs in platinum-treated SCCs. Methods: miRNA expression data of platinum-treated head and neck (HNSC), cervical (CESC) and lung (LUSC) cancer were collected from the TCGA repositories. Treatment response was defined based on presence or absence of disease progression at 18 months. Responder and nonresponder cohorts were comp

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Shan, Yuting, Yingbo Huang, Adam Lee, Radwa Elmorsi, Tuyen Phan, and R. Stephanie Huang. "Abstract 6518: Sex-biased intratumoral microbiome impact cancer cell proliferation and treatment outcomes in gastrointestinal cancers." Cancer Research 85, no. 8_Supplement_1 (2025): 6518. https://doi.org/10.1158/1538-7445.am2025-6518.

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Abstract Objectives: Sex differences in cancer treatment responses and disease prognosis are well-documented. Our study investigates the intratumoral microbiome, hypothesizing that its composition varies between sexes which contributes to the observed differences. Specifically, our study aims to identify sex-biased intratumoral microbiome and investigate their influence on host gene expression, survival rates, and responses to treatment. Method: We analyzed intratumoral microbiome abundance in 5 gastrointestinal cancers to identify differentially abundant (DA) microbes between sexes. After ini

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15

Wu, Yi-Fen, Xiao-Hui Jiang, and Dan-Ting Qian. "Establishment and validation of a novel risk model based on PANoptosis-related genes to predict prognosis in head and neck squamous cell carcinoma." Medicine 104, no. 18 (2025): e42299. https://doi.org/10.1097/md.0000000000042299.

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Head and neck squamous cell carcinoma (HNSC) is a common cancer worldwide with poor prognosis. Current treatment methods have limited effect on improving the prognosis of patients with HNSC. Differentially expressed PANoptosis-related genes in HNSC were identified from the TCGA using limma and WGCNA. A prognostic model was established using univariate and multivariate Cox regression analyses and machine learning, and its performance was evaluated using Kaplan–Meier and receiver operating characteristic curves. SNP data was analyzed using maftools package. Immune analysis was performed using IO

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Arumugam, Paramasivam, Vijayashree Priyadharsini Jayaseelan, and Abilasha Ramasubramanian. "METTL3 as a potential predictive biomarker for immunotherapy response in metastatic head and neck cancer." Journal of Clinical Oncology 42, no. 16_suppl (2024): e18019-e18019. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e18019.

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e18019 Background: Head and neck squamous cell carcinoma (HNSCC) that has metastasized presents a significant challenge for cancer treatment, requiring innovative approaches to predict immunotherapy response. Methyltransferase-like 3 (METTL3), a key component of the m6A RNA methylation machinery, has been shown to have various roles in cancer, including its potential impact on immunotherapy responses. In this study, we aim to explore the expression and related function of METTL3 in metastatic HNSCC. Methods: We investigated the expression level and its clinicopathological significance of METTL

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Almouhanna, Firas, and Jochen Hess. "An ESR1-Related Gene Signature Identifies Head and Neck Squamous Cell Carcinoma with Imputed Susceptibility to Endocrine Therapy." International Journal of Molecular Sciences 25, no. 2 (2024): 1244. http://dx.doi.org/10.3390/ijms25021244.

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Head and neck squamous cell carcinoma (HNSCC) is associated with high morbidity and mortality. New personalized treatment strategies represent an unmet medical need to improve the overall survival and the quality of life of patients, which are often limited by the toxicity of established multimodal treatment protocols. Several studies have reported an increased expression of the estrogen receptor 1 (ESR1) in HNSCC, but its potential role in the disease outcome of these tumors remains elusive. Using an integrative analysis of multiomics and clinical data from The Cancer Genome Atlas (TCGA)-HNSC

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18

Grau, J. J., M. Caballero, E. Verger, and J. L. Blanch. "Actual proportion of patients (pts) receiving chemotherapy or cetuximab for head and neck squamous carcinoma (HNSC)." Journal of Clinical Oncology 27, no. 15_suppl (2009): e17058-e17058. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e17058.

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e17058 Background: With the new indications of chemotherapy or cetuximab in HNSC, the rate of pts receiving these therapies nowadays is unclear. Methods: This retrospective study identified all consecutive pts with HNSC from January 1, 2006, to December 31, 2007, presented in a multidisciplinary team to decide further treatment in a single institution. ASCO guidelines for larynx preservation were followed to select surgery or chemoradiotherapy (ChRt). We classified the intention-to-treat as palliative, adjuvant or induction therapy. In the last case, always with concomitant radiotherapy (Rt) o

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Baulch, Janet E., Munjal M. Acharya, Barrett D. Allen, et al. "Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain." Proceedings of the National Academy of Sciences 113, no. 17 (2016): 4836–41. http://dx.doi.org/10.1073/pnas.1521668113.

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Cancer survivors face a variety of challenges as they cope with disease recurrence and a myriad of normal tissue complications brought on by radio- and chemotherapeutic treatment regimens. For patients subjected to cranial irradiation for the control of CNS malignancy, progressive and debilitating cognitive dysfunction remains a pressing unmet medical need. Although this problem has been recognized for decades, few if any satisfactory long-term solutions exist to resolve this serious unintended side effect of radiotherapy. Past work from our laboratory has demonstrated the neurocognitive benef

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Zewde, Makda Getachew, Daniel Fulop, Alexander Tsankov, and Kuan-lin Huang. "Abstract A47: Characterization of immune cell composition across cancer types in pan-cancer genomic cohorts." Cancer Immunology Research 10, no. 12_Supplement (2022): A47. http://dx.doi.org/10.1158/2326-6074.tumimm22-a47.

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Abstract Introduction: Identifying immune cell signatures in individual tumors can help guide treatment selection for patients. Numerous deconvolution methods have been developed to estimate immune cell fractions from bulk gene expression data, but they have yet to be systematically applied and cross-validated in pan-cancer genomic cohorts. We undertook this study to cross-validate immune cell quantification methods across 25 cancer types spanning 11,011 samples and provide a public immuno-oncology resource. Methods: Using gene expression data from both The Cancer Genome Atlas (TCGA) and the I

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21

Yang, Linhui, Zhiwei Chen, Yunliang Liu, Xiaoyan Wang, Jing Li, and Qing Ye. "Immunization Combined with Ferroptosis Related Genes to Construct a New Prognostic Model for Head and Neck Squamous Cell Carcinoma." Cancers 14, no. 17 (2022): 4099. http://dx.doi.org/10.3390/cancers14174099.

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Ferroptosis is a new type of programmed cell death that plays a pivotal role in a variety of tumors. Moreover, immunity is closely related to ferroptosis. However, immune-ferroptosis-related mRNAs (IFRMs) are still not fully understood in the regulation of head and neck squamous cell carcinoma (HNSC). The purpose of this paper was to investigate the IFRMs prediction of HNSC and its possible molecular biological role. RNA-Seq and related clinical data were mined from the TCGA database, ImmPort database, GeneCards database, FerrDb database, and previous data. In R software, the “DESeq2” package

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Kim, Nari, Mi-Hyun Kim, Junhee Pyo, et al. "CCR8 as a Therapeutic Novel Target: Omics-Integrated Comprehensive Analysis for Systematically Prioritizing Indications." Biomedicines 11, no. 11 (2023): 2910. http://dx.doi.org/10.3390/biomedicines11112910.

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Target identification is a crucial process in drug development, aiming to identify key proteins, genes, and signal pathways involved in disease progression and their relevance in potential therapeutic interventions. While C-C chemokine receptor 8 (CCR8) has been investigated as a candidate anti-cancer target, comprehensive multi-omics analyzes across various indications are limited. In this study, we conducted an extensive bioinformatics analysis integrating genomics, proteomics, and transcriptomics data to establish CCR8 as a promising anti-cancer drug target. Our approach encompassed data co

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23

Erdim, Ibrahim. "Parotidectomy in head-neck skin cancers: Our clinical experience." Praxis of Otorhinolaryngology 10, no. 3 (2022): 101–9. http://dx.doi.org/10.5606/kbbu.2022.88262.

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Objectives: In this study, our experience on diagnosis, treatment, and follow-up processes of patients who underwent parotidectomy for head-neck skin cancer (HNSC) was presented. Patients and Methods: A total of 30 patients (20 male, 10 female; mean age: 76±9.8 year; range, 50 to 90 year) who underwent elective and therapeutic parotidectomy for HNSC between January 2012 and January 2020 were included this retrospective study. Results: Elective parotidectomy was performed on 11 (36.7%) patients, and therapeutic parotidectomy was performed on 19 (63.3%) patients. Primary tumor histopathology was

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Madan, Sanna, Sanju Sinha, Alejandro A. Schäffer, and Eytan Ruppin. "Abstract LB062: Identifying novel targets for CAR-T therapies from single cell RNA-sequencing data." Cancer Research 83, no. 8_Supplement (2023): LB062. http://dx.doi.org/10.1158/1538-7445.am2023-lb062.

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Abstract Chimeric antigen receptor T (CAR-T) cell therapies have revolutionized cancer treatment. While CAR-T has yielded tremendous clinical success for patients with liquid tumors, its potential remains to be unleashed against solid tumors. One key challenge is identifying optimal targets for these therapies: cell surface proteins that are expressed highly and uniformly by a tumor’s constituent malignant cells, and minimally so by healthy tissues. Employing a systematic, data-driven analysis, we first charted the landscape of existing CAR-T targets in the clinic, identifying the leading targ

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Li, Yuan, Jiagen Li, Nan Sun, et al. "Identification and functional characterization of long noncoding RNA NMR as biomarker for metastasis and prognosis in esophageal squamous cell carcinoma." Journal of Clinical Oncology 35, no. 15_suppl (2017): e15587-e15587. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e15587.

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e15587 Background: Long noncoding RNAs (lncRNA) have been implicated in cancer but most of them remain largely unstudied. Methods: In this study, we identified a NSUN2 methylated lncRNA (NMR), which is significantly upregulated in esophageal squamous cell carcinoma (ESCC), functions as a key regulator of ESCC tumor metastasis and drug resistance. Results: In microarray data of 119 paired ESCC and normal tissues, NMR was significantly overexpressed in ESCC (P < 0.001), and overexpression of NMR indicated poor overall survival of ESCC patients (P = 0.003); in RNA sequencing data of 20 cancer

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Acharya, Munjal M., Lori-Ann Christie, Thomas G. Hazel, Karl K. Johe, and Charles L. Limoli. "Transplantation of Human Fetal-Derived Neural Stem Cells Improves Cognitive Function following Cranial Irradiation." Cell Transplantation 23, no. 10 (2014): 1255–66. http://dx.doi.org/10.3727/096368913x670200.

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Treatment of central nervous system (CNS) malignancies typically involves radiotherapy to forestall tumor growth and recurrence following surgical resection. Despite the many benefits of cranial radiotherapy, survivors often suffer from a wide range of debilitating and progressive cognitive deficits. Thus, while patients afflicted with primary and secondary malignancies of the CNS now experience longer local regional control and progression-free survival, there remains no clinical recourse for the unintended neurocognitive sequelae associated with their cancer treatments. Multiple mechanisms c

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Huang, Hung-Han, Guo-Rung You, Kai-Hsin Lin, Yin-Ju Chen, and Ann-Joy Cheng. "Abstract 5694: Elucidating areca nut-induced miRNA-mRNA regulatory networks in head and neck cancer pathogenesis." Cancer Research 84, no. 6_Supplement (2024): 5694. http://dx.doi.org/10.1158/1538-7445.am2024-5694.

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Abstract Areca nut has been considered a high-risk carcinogen for head and neck cancer (HNC) in Southeast Asia, while its molecular effects, especially on the miRNA regulatory roles, remain elusive. This study characterized miRNA-mRNA networks associated with areca nut-related HNC. We integratively analyzed the areca nut-induced mRNA profile and TCGA-HNSC gene set. A total of 2575 genes were identified, with 1971 upregulated and 604 downregulated in cancers. The KEGG pathway analysis revealed that these genes were enriched in the cellular functions related to motility and stress response. Expe

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Wang, Jun-Ling, Hong-Wei Li, Hong-Xia Liu, et al. "Abstract 2108: Comparative analysis of fusion gene detection rates in tissue versus blood samples from Chinese diverse solid tumors." Cancer Research 85, no. 8_Supplement_1 (2025): 2108. https://doi.org/10.1158/1538-7445.am2025-2108.

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Abstract Background: The landscape of genetic alterations, particularly fusion genes, plays a critical role in the diagnosis and treatment of various solid tumors. As liquid biopsy methods evolve, understanding the differences in mutation frequencies between tissue and blood samples becomes essential for precision oncology. This study aimed to evaluate the detection rates of specific fusion genes in both tumor tissue and blood samples from patients with diverse solid tumors using a 733-gene panel through Next-Generation Sequencing (NGS). Methods: We conducted a comprehensive analysis of 23 typ

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Lee, Suyeon, Heewon Jung, Jiwoo Park, and Jaegyoon Ahn. "Accurate Prediction of Cancer Prognosis by Exploiting Patient-Specific Cancer Driver Genes." International Journal of Molecular Sciences 24, no. 7 (2023): 6445. http://dx.doi.org/10.3390/ijms24076445.

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Accurate prediction of the prognoses of cancer patients and identification of prognostic biomarkers are both important for the improved treatment of cancer patients, in addition to enhanced anticancer drugs. Many previous bioinformatic studies have been carried out to achieve this goal; however, there remains room for improvement in terms of accuracy. In this study, we demonstrated that patient-specific cancer driver genes could be used to predict cancer prognoses more accurately. To identify patient-specific cancer driver genes, we first generated patient-specific gene networks before using m

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Kholod, Olha, William Basket, Danlu Liu, et al. "Identification of Immuno-Targeted Combination Therapies Using Explanatory Subgroup Discovery for Cancer Patients with EGFR Wild-Type Gene." Cancers 14, no. 19 (2022): 4759. http://dx.doi.org/10.3390/cancers14194759.

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(1) Background: Phenotypic and genotypic heterogeneity are characteristic features of cancer patients. To tackle patients’ heterogeneity, immune checkpoint inhibitors (ICIs) represent some the most promising therapeutic approaches. However, approximately 50% of cancer patients that are eligible for treatment with ICIs do not respond well, especially patients with no targetable mutations. Over the years, multiple patient stratification techniques have been developed to identify homogenous patient subgroups, although matching a patient subgroup to a treatment option that can improve patients’ he

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Lv, Ran, Fang Lv, Pei Zhihua, et al. "Noninvasive detection of chromosomal instability in plasma circulating cell-free DNA for early pan-cancer diagnosis using low-pass whole-genome sequencing." Journal of Clinical Oncology 39, no. 15_suppl (2021): e22509-e22509. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e22509.

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e22509 Background: Genomic instability is a typical characteristic of the majority of cancers. Early non-invasive detection of cancer is the most effective way of improving the success of treatment and prognosis at present. Traditional tumor screening methods have limitations in terms of selection methods, sensitivity, specificity, cost, and comfortability. Furthermore, although traditional tumor screening is useful for common cancers, there is no available screening test for rare cancers. Here we developed a novel method for cancer detection with Low-Pass Whole Genome Sequencing (WGS) of cell

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Koenigs, Maria B., Armida Lefranc-Torres, Juliana Bonilla-Velez, et al. "Association of Estrogen Receptor Alpha Expression With Survival in Oropharyngeal Cancer Following Chemoradiation Therapy." JNCI: Journal of the National Cancer Institute 111, no. 9 (2019): 933–42. http://dx.doi.org/10.1093/jnci/djy224.

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Abstract Background Oropharyngeal squamous carcinoma (OPSC) continues to increase in incidence secondary to human papillomavirus (HPV) infection. Despite the good overall prognosis for these patients, treatment with chemoradiation is associated with morbidity and treatment failure. Better predictors for disease outcome are needed to guide de-intensification regimens. We hypothesized that estrogen receptor α (ERα), a prognostic biomarker in oncology with therapeutic implications, might have similar utility in OPSC. Methods To investigate associations among ERα and demographics, HPV status, and

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Ghosh, Maloy, Anurag Tiwari, Ashvini Kumar Dubey, et al. "Abstract 7535: First-in-human phase 1 clinical trial of ZM008, a monoclonal IgG1 targeting LLT1, monotherapy and in combination with pembrolizumab in advanced solid tumors." Cancer Research 84, no. 6_Supplement (2024): 7535. http://dx.doi.org/10.1158/1538-7445.am2024-7535.

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Abstract Lectin-like transcript 1 (LLT1) interaction with CD161 receptor on NK cells facilitates tumor immune escape. Hence, blocking LLT1-CD161 interaction could potentially activate NK cells and resulted tumor cell cytotoxicity. ZM008 is a first-in-class anti LLT1 monoclonal antibody with promising pre-clinical safety, efficacy data and received IND approval from USFDA. Clinical study will start soon at multiple US sites. TCGA data analysis revealed high LLT1 gene expression in multiple solid cancers BRCA, CHOL, ESCA, GBM, HNSC, KIRC, KIRP, LIHC, LUAD, STAD, SARC. Several immune checkpoint g

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Liu, Jinhui, Yuanyuan Wang, Jian Yin, et al. "Pan-Cancer Analysis Revealed SRSF9 as a New Biomarker for Prognosis and Immunotherapy." Journal of Oncology 2022 (January 12, 2022): 1–21. http://dx.doi.org/10.1155/2022/3477148.

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Background. Serine/arginine-rich splicing factor 9 (SRSF9) is one of the members of SRSF gene family and related to the tumorigenesis and the progression of tumor. However, whether SRSF9 has a crucial role across pan-cancer is still unknown. Methods. In this study, we used public databases, such as The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), and Genotype-Tissue Expression (GTEx), to analyze SRSF9 expression level among tumor and normal cells. Survival analysis, K-M plotter, and PrognoScan were used to analyze the prognosis value of SRSF9, regarding to overall survival

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Wu, Sheng, Xiangkang Lv, Yilin Li, et al. "Integrated Machine Learning and Single-Sample Gene Set Enrichment Analysis Identifies a TGF-Beta Signaling Pathway Derived Score in Headneck Squamous Cell Carcinoma." Journal of Oncology 2022 (September 1, 2022): 1–12. http://dx.doi.org/10.1155/2022/3140263.

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Background. The TGF-β signaling pathway is clinically predictive of pan-cancer. Nevertheless, its clinical prognosis and regulation of immune microenvironment (TME) characteristics as well as the prediction of immunotherapy efficacy need to be further elucidated in head and neck squamous cell carcinoma. Method. At first, we summarized TGF-β related genes from previous published articles, used ssGSEA to establish the TGF-β risk score. Considering the complexity of its clinical application, we improved it with the LASSO-COX algorithm to construct the model. In addition, we explored the predictiv

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Long, Zhi-Qing, Ran Ding, Ting-Qiu Quan, et al. "Multi-Omics Characterization of Genome-Wide Abnormal DNA Methylation Reveals FGF5 as a Diagnosis of Nasopharyngeal Carcinoma Recurrence After Radiotherapy." Biomolecules 15, no. 2 (2025): 283. https://doi.org/10.3390/biom15020283.

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Background: Aberrant expression and mutations in the fibroblast growth factor (FGF) family play crucial roles in cell differentiation, growth, and migration, contributing to tumor progression across various cancers. Nasopharyngeal carcinoma (NPC), a malignancy prevalent in East Asia, is primarily treated with radiotherapy; however, radioresistance remains a major challenge, leading to recurrence and poor outcomes. While FGFs are known to activate signaling pathways such as MAPK, PI3K/AKT, and JAK/STAT to promote cancer progression, the specific role of individual FGFs in NPC radioresistance re

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Garb, Bailey F., Shiting Li, Tingting Qin, et al. "Abstract 3491: Tumor subtype classification of HPV-associated head and neck cancers is central to key clinically relevant variables." Cancer Research 84, no. 6_Supplement (2024): 3491. http://dx.doi.org/10.1158/1538-7445.am2024-3491.

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Abstract Cancer types are typically categorized according to the cell of origin, but within these groupings there exists vast heterogeneity. Thus, subtypes based on molecular features are often defined that have clinical utility as prognostic biomarkers, aid in selection of therapeutic strategies, or are associated with treatment response. Head and neck cancer (HNC) is the seventh most common cancer globally and projected to have 54,540 new cases in the U.S. in 2023. Within the US, HPV(+) HNC is now more prevalent than HPV(+) cervical cancer, and it is expected to continue to rise. Although th

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Duran, Juan Felipe, Yujing Zou, Harry Glickman, et al. "Abstract A059: CP-Fuse: A Comprehensive Assessment of Clinico-Pathological Fusion in TCGA Survival Prediction." Clinical Cancer Research 31, no. 13_Supplement (2025): A059. https://doi.org/10.1158/1557-3265.aimachine-a059.

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Abstract Cancer remains a leading cause of global mortality. Multidisciplinary tumor boards play a central role in diagnosis and treatment planning but often face challenges related to growing case complexity, time constraints, and inconsistent expertise. Artificial intelligence models that incorporate diverse data sources such as histopathology and clinical records offer valuable decision-support tools, and multimodal approaches have been shown to outperform unimodal methods. This study introduces CP-Fuse, a novel multimodal framework that aims to improve progression-free survival (PFS) predi

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Mahmoud, Yamil Damian, Florencia Veigas, Joaquin Merlo, et al. "Bioinformatic profiling of tumor immunity from patient biopsies to predict survival and response to immunotherapy." Journal of Clinical Oncology 38, no. 15_suppl (2020): e15198-e15198. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e15198.

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e15198 Background: Immunotherapies have revolutionized cancer treatment, but responses are not universal and patients who initially respond to therapy develop resistance. The accurate quantification of tumor-infiltrating immune cells holds the promise to reveal the role of the immune system in human cancers and its involvement in tumor escape mechanisms and response to therapy. We present MIXTURE, a new algorithm for tumor immune cell-type proportions deconvolution from transcriptomic data that overcomes competitive methods and revealed novel associations of immune cell types with patient surv

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Kannan, Balachander, Vijayashree Priyadharsini Jayaseelan, Senthil MuruganM, and Paramasivam Arumugam. "Abstract 1727: Silencing of novel m6A reader PRRC2A as a therapeutic strategy for oral cancer." Cancer Research 84, no. 6_Supplement (2024): 1727. http://dx.doi.org/10.1158/1538-7445.am2024-1727.

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Abstract Background: Oral squamous cell carcinoma (OSCC) poses a substantial global health challenge characterized by limited treatment options and unfavorable prognoses. Recent research has illuminated the pivotal role of N6-methyladenosine (m6A) modification and its regulators in cancer biology. However, the precise involvement of a novel m6A regulator (m6A reader), PRCC2A in OSCC remains inadequately understood. Objective: This study aims to unravel the role of PRCC2A in OSCC and ascertain its potential as both a diagnostic biomarker and a therapeutic target. Methods: We collected 76 OSCC t

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Cirillo, Nicola, Carmen Wu, and Stephen S. Prime. "Heterogeneity of Cancer Stem Cells in Tumorigenesis, Metastasis, and Resistance to Antineoplastic Treatment of Head and Neck Tumours." Cells 10, no. 11 (2021): 3068. http://dx.doi.org/10.3390/cells10113068.

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The discovery of a small subset of cancer cells with self-renewal properties that can give rise to phenotypically diverse tumour populations has shifted our understanding of cancer biology. Targeting cancer stem cells (CSCs) is becoming a promising therapeutic strategy in various malignancies, including head and neck squamous cell carcinoma (HNSCC). Diverse sub-populations of head and neck cancer stem cells (HNCSCs) have been identified previously using CSC specific markers, the most common being CD44, Aldehyde Dehydrogenase 1 (ALDH1), and CD133, or by side population assays. Interestingly, di

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Prince, Mark E. P., and Laurie E. Ailles. "Cancer Stem Cells in Head and Neck Squamous Cell Cancer." Journal of Clinical Oncology 26, no. 17 (2008): 2871–75. http://dx.doi.org/10.1200/jco.2007.15.1613.

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Appropriate treatment of head and neck squamous cell cancer (HNSCC) remains one of the most difficult challenges in head and neck oncology. Overall survival of patients with HNSCC remains at approximately 50% at 5 years. Surgical therapy can be mutilating and often has significant effects on swallowing, speech, and physical appearance. The addition of chemotherapy to radiation treatment has shown efficacy in organ preservation in some sites in the head and neck, but has resulted in limited improvement in survival rates. HNSCC resistance to chemotherapy has limited the usefulness of chemotherap

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Mordzińska-Rak, Aleksandra, Ilona Telejko, Grzegorz Adamczuk, Tomasz Trombik, Andrzej Stepulak, and Ewa Błaszczak. "Advancing Head and Neck Cancer Therapies: From Conventional Treatments to Emerging Strategies." Biomedicines 13, no. 5 (2025): 1046. https://doi.org/10.3390/biomedicines13051046.

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Head and neck cancers (HNCs), particularly head and neck squamous cell carcinoma (HNSCC), are among the most aggressive and prevalent malignancies of the upper aerodigestive tract. As the incidence of HNCs continues to rise, this cancer type presents a significant public health challenge. Despite conventional treatment options, such as surgery, chemotherapy, and radiotherapy, the five-year survival rates remain relatively low due to resistance to these therapies, local recurrence, local lymph node metastasis, and in some advanced cases also distant metastasis. Consequently, patients with HNCs

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Rajabi-Moghaddam, Mahdieh, and Hamid Abbaszadeh. "Evaluation of prognostic factors of head and neck squamous cell carcinomas in Iranian patients: A narrative review." Journal of Oral Health and Oral Epidemiology 13, no. 2 (2024): 45–48. http://dx.doi.org/10.34172/johoe.2209.1505.

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Background: Head and neck squamous cell carcinoma (HNSCC) represents the largest proportion of head and neck cancers (HNCs). Despite new treatment modalities, the 5-year survival rate has not improved much. Identifying the factors affecting the prognosis and survival of patients is the first step in trying to improve the prognosis of these patients. The aim of this review was to investigate prognostic factors of HNSCC in Iran. Methods: A web-based search of all original articles conducted in Iran until October 2022 on prognostic factors of HNSCC was done using English and Persian language data

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Xing, Juanli, Yanan Gu, Yichen Song, et al. "MYO5A overexpression promotes invasion and correlates with low lymphocyte infiltration in head and neck squamous carcinoma." BMC Cancer 23, no. 1 (2023). http://dx.doi.org/10.1186/s12885-023-11759-5.

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AbstractHead and neck squamous carcinoma (HNSC) poses a significant public health challenge due to its substantial morbidity. Nevertheless, despite advances in current treatments, the prognosis for HNSC remains unsatisfactory. To address this, single-cell RNA sequencing (RNA-seq) and bulk RNA-seq data combined with in vitro studies were conducted to examine the role of MYO5A (Myosin VA) in HNSC. Our investigation revealed an overexpression of MYO5A in HNSC that promotes HNSC migration in vitro. Remarkably, knockdown of MYO5A suppressed vimentin expression. Furthermore, analyzing the TCGA datab

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Hu, Yuan, Jiexin Chen, Muyuan Liu, Qin Feng, and Hanwei Peng. "IGF2BP2 serves as a core m6A regulator in head and neck squamous cell carcinoma." Bioscience Reports, October 25, 2022. http://dx.doi.org/10.1042/bsr20221311.

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Methylation of N6 adenosine (m6A) plays a crucial role in the development and progression of cancers. Its modification is regulated by three types of m6A-related regulators (methyltransferases (writers), demethylases (erasers), and RNA binding proteins (readers)). Till now, the functions and roles of these regulators in head and neck squamous cell carcinoma (HNSC) remain largely unexplored. Therefore, we utilized the open HNSC dataset in Cancer Genome Atlas (TCGA), 4 different cell lines and our HNSC patient samples (n = 40) to explore the clinical significance of 19 m6A regulators, and select

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Tiblom Ehrsson, Ylva, Sandra Einarsson, Per Fransson, and Göran Laurell. "Swedish Translation and Cultural Adaptation of the Head and Neck Patient Symptom Checklist: An Instrument to Screen for Nutrition Impact Symptoms in Clinical Practice and Research." Western Journal of Nursing Research, August 24, 2024. http://dx.doi.org/10.1177/01939459241274342.

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Background: The Head and Neck Patient Symptom Checklist (HNSC) is a validated 2-part instrument used to ask patients with head and neck cancer about the nutrition impact symptoms they experience (part 1) and how these interfere with their eating (part 2). Purpose: The purpose of this work was to translate and culturally adapt the HNSC into Swedish in accordance with the guidelines of the International Society for Health Economics and Outcomes Research (ISPOR). Methods: The ISPOR guidelines include 10 steps, and these were thoroughly followed. In step 7, 9 health care professionals from the fie

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Liu, Peng, Xin Kong, Shijiang Yi, Ying Chen, and Wenlong Luo. "IFIT3 accelerates the progression of head and neck squamous cell carcinoma by targeting PD-L1 to activate PI3K/AKT signaling pathway." World Journal of Surgical Oncology 22, no. 1 (2024). http://dx.doi.org/10.1186/s12957-023-03274-5.

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Abstract Background Emerging evidence has shown interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) may be predicted to be a candidate oncogene and involved in the onset and progression of cancer, but IFIT3’s potential role in cancer, particularly in head and neck squamous cell carcinoma (HNSC), is not well recognized. This study aims to reveal the role of IFIT3 in HNSC and the underlying molecular mechanism. Methods Bioinformatics analysis, immunohistochemical staining, RT-PCR, and Western blotting analysis were used to detect IFIT3 expression in HNSC. CCK-8 assays, colony for

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Liu, Baoling, Quanping Su, Jianhua Ma, et al. "Prognostic Value of Eight-Gene Signature in Head and Neck Squamous Carcinoma." Frontiers in Oncology 11 (June 18, 2021). http://dx.doi.org/10.3389/fonc.2021.657002.

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Head and neck cancer (HNC) is the fifth most common cancer worldwide. In this study, we performed an integrative analysis of the discovery set and established an eight-gene signature for the prediction of prognosis in patients with head and neck squamous cell carcinoma (HNSCC). Univariate Cox analysis was used to identify prognosis-related genes (with P &lt; 0.05) in the GSE41613, GSE65858, and TCGA-HNSC RNA-Seq datasets after data collection. We performed LASSO Cox regression analysis and identified eight genes (CBX3, GNA12, P4HA1, PLAU, PPL, RAB25, EPHX3, and HLF) with non-zero regressio

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Yang, Bin, Wei Sun, Ping Peng, and Dongbo Liu. "Stepwise single-cell data identifies RNA binding proteins associated with the development of head and neck cancer and tumor microenvironment remodeling." Cancer Biomarkers 42, no. 2 (2025). https://doi.org/10.1177/18758592251328172.

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Background : Head and neck squamous cell carcinoma (HNSC) is a globally prevalent malignancy with high mortality rates. RNA-binding proteins (RBPs) are crucial regulators of gene expression and play significant roles in cancer development. However, a comprehensive understanding of RBPs at the single-cell level in HNSC remains limited. Objective This study aims to investigate the role of RBPs in the stepwise progression of HNSC at the single-cell level, focusing on their expression patterns, prognostic potential, and involvement in key signaling pathways. Methods We analyzed single-cell RNA-seq

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