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Dissertations / Theses on the topic 'Hodgkin lymphoma'

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Published: 4 June 2021

Last updated: 26 July 2025

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1

Busson, Raphaël. "Fatigue chronique chez les survivants d'un lymphome." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC238/document.

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La progression des traitements dans le lymphome amène à s’intéresser à la qualité de vie des survivants. La fatigue chronique est le problème le plus fréquemment décrit par les survivant. Dans le cadre du lymphome hodgkinien, le niveau de fatigue revêt une importance particulière par les patients ont entre 20 et 40 ans et sont confronté aux problématiques de retour à l’emploi. Dans la première partie de cette thèse, nous traiterons des causes de la fatigue et de sont évolutions pour les lymphomes hodgkinien et les lymphomes non-hodgkinien. En particulier, nous mettrons en lumière l’impacte des

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2

Majeed, Aneela, Onyee Chan, Onyemaechi Okolo, Volodymyr Shponka, Anca Georgescu, and Daniel Persky. "Hodgkin Lymphoma Mimicking Osteomyelitis." KARGER, 2017. http://hdl.handle.net/10150/625840.

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Hodgkin lymphoma with symptomatic osseous involvement can have a similar presentation to osteomyelitis. Common findings in symptoms, laboratory workup, and imaging can make it very difficult to distinguish between the two diseases. Excisional biopsy should be pursued if fine-needle biopsy is equivocal and suspicion of lymphoma is high. We report a case of a 40-year-old man who presented with a history of marine animal sting on his neck and later developed erythema in the area, chest pain, constitutional symptoms, adenopathy, and imaging classic for sternal osteomyelitis. Fortunately, initial b

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3

Amini, Rose-Marie. "Hodgkin Lymphoma : Studies of Advanced Stages, Relapses and the Relation to Non-Hodgkin Lymphomas." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5265-5/.

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4

Cuceu, Corina. "Telomere Dysfunction And Chromosomal Instability In Hodgkin Lymphoma." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS210/document.

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Le lymphome de Hodgkin est caractérisé, d’un point de vue histologique, par la présence de rares cellules tumorales nommées cellules de Reed et Sternberg, au sein d’un infiltrat cellulaire polymorphe, inflammatoire et réactionnel. Cette dernière résulte de la transformation tumorale de cellules lymphocytaires B qui acquièrent des propriétés d’échappement au système immun, de prolifération, de résistance à l’apoptose et une instabilité chromosomique. Néanmoins, la rareté des cellules tumorales, impliquant des problèmes techniques mais aussi de caractérisation des évènements primaires dans l’ini

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5

Ferreira, Filho José Laurentino 1990. "Relation between digit ratio (2D:4D) and Hodgkin's lymphoma." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/287812.

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Orientador: Jacks Jorge Junior<br>Texto em português e inglês<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-25T06:56:55Z (GMT). No. of bitstreams: 1 FerreiraFilho_JoseLaurentino_M.pdf: 1327041 bytes, checksum: 2b08a1dcef02da5393c3fdad74be531f (MD5) Previous issue date: 2014<br>Resumo: Estudos sugerem que a proporção digital pode ser utilizada como marcador putativo para a exposição pré-natal a hormônios sexuais e como marcador da expressão de genes HOX. Genes homeobox controlam a organogênese e a f

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6

Molin, Daniel. "Bystander Cells and Prognosis in Hodgkin Lymphoma." Doctoral thesis, Uppsala University, Department of Oncology, Radiology and Clinical Immunology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2547.

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<p>Hodgkin lymphoma (HL) is characterised histologically by a minority of malignant Hodgkin and Reed-Sternberg (HRS) cells surrounded by benign cells, and clinically by a relatively good prognosis. The treatment, however, leads to a risk of serious side effects. Knowledge about the biology of the disease, particularly the interaction between the HRS cells and the surrounding cells, is essential in order to improve diagnosis and treatment. </p><p>HL patients with abundant eosinophils in the tumours have a poor prognosis, therefore the eosinophil derived protein eosinophil cationic protein (ECP)

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7

Bley, Linda D. "Nutritional factors and non-Hodgkin's Lymphoma /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/10864.

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8

Bur, H. (Hamid). "Biological prognostic and predictive markers in Hodgkin lymphoma." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526219455.

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Abstract Hodgkin lymphoma (HL) is among a heterogeneous group of lymphomas. Over 80% of all patients can be cured with chemo- and radiotherapy. HL has become a model to study long-term effects of radio- and chemotherapy, because of the excellent prognosis. There are a significant number of patients who suffer or die because of the treatment-related long-term toxicity. The aim of this work was to discover new possible biological factors to predict poor prognosis and offer new aspects to individualize patient treatment in a convenient manner in HL. The retrospective study involved HL patients un

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9

Englund, Annika. "Hodgkin Lymphoma in children, adolescents and young adults." Doctoral thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316796.

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Hodgkin lymphoma (HL) is a heterogeneous condition varying from engaging one single lymph node site to a widespread condition. The prognosis with contemporary treatment is excellent for the vast majority. However, the treatment might cause severe late adverse effects in a proportion of the affected individuals. We evaluated all children and adolescents diagnosed in Sweden and registered in the Swedish Childhood Cancer Register over a period of 25 years. The incidence has been stable and the overall survival (OS) is very good, comparable to the best results in the world. Approximately ten perce

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10

Aleman, Berthe Mauricia Pauline. "Optimizing treatment of patients with Hodgkin's lymphoma." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2007. http://dare.uva.nl/document/43623.

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11

Chui, Daniel. "Molecular cytogenetic studies in the Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma." Thesis, University of Glasgow, 2004. http://theses.gla.ac.uk/5396/.

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To determine whether recurrent genomic imbalances are a feature of HL, CD30-positive HRS cells were laser microdissected from 20 cHL cases and 4 HL-derived cell lines and subjected to analyses by CGH. In primary tumours, the most frequently involved chromosomal gains were 17q (70%), 2p (40%), 12q (40%), 17p (40%), 22q (35%), 9p (30%), 14q (30%), 16p (30%), with minimal overlapping regions at 17q21, 2p23-13, 12q24, 17p13, 22q13, 9p24-33, 14q32, 16p13.3 and 16p11.2. The most frequent losses involved 13q (35%), 6q (30%), 11q (25%) and 4q (25%), with corresponding minimal overlapping regions at 13

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12

Glimelius, Ingrid. "Hodgkin Lymphoma – an Interplay Between Tumour Cell and Microenvironment." Doctoral thesis, Uppsala universitet, Institutionen för onkologi, radiologi och klinisk immunologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100593.

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Hodgkin lymphoma (HL) is a malignant disorder characterised by few tumour cells surrounded by a massive infiltrate of inflammatory cells, fibrosis, and microvessels. Therefore, it is a good model in which to study the interplay between tumour cells and the microenvironment. In a population-based series, stage IIB had poor prognosis, equivalent to the most advanced stage (stage IV). The most prominent negative prognostic factor was tumour bulk in the mediastinum (often large fibrotic tumours). The tumour cells expressed interleukin-9 (IL-9) in their cytoplasm in half of the cases. These cases h

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13

Herrmann, Franziska [Verfasser]. "Role of FOXO3 in classical Hodgkin lymphoma / Franziska Herrmann." Ulm : Universität Ulm, 2019. http://d-nb.info/1184989869/34.

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14

Dean, Robert T. G. "An investigation into cellular stress pathways in Hodgkin lymphoma." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5225/.

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Hodgkin lymphoma (HL) is one of the most common haematological malignancies in the Western world. Although HL responds favourably to cytotoxic therapy in the majority of cases, late side-effects such as secondary malignancies and cardiovascular disease are becoming of great concern, particularly in younger patients. The current challenges are to maintain treatment efficacy whilst reducing side-effects and to develop biomarkers to predict response to treatment(s). Protein degradation pathways in HL cells have remained largely unstudied in this malignancy and represent an opportunity for more ta

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15

Holmes, Matthew. "Oncolytic virotherapy for the treatment of Non-Hodgkin Lymphoma." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/22218/.

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Non-Hodgkin Lymphoma (NHL) is a diverse group of more than 80 predominantly B cell cancers of the lymphatic system. Poor survival rates in aggressive subsets, the transformation of indolent subsets into aggressive forms, and the emergence of therapy-resistance warrants research into novel therapies. Oncolytic viruses (OV) preferentially replicate in and kill malignant cells. Here we investigate the efficacy of two OV, reovirus Type 3 Dearing and Coxsackievirus Type A21 (CVA21), against NHL cell lines and primary patient samples, examine the role of the tumour microenvironment in virus suscepti

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16

Duc, Touyana. "Caractérisation moléculaire et sérologique de l'infection à Epstein-Barr virus chez les patients porteurs du VIH souffrant d'un lymphome." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV074.

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En 2016, les lymphoproliférations malignes [lymphome malin non hodgkinien (LNH) et lymphome de Hodgkin (LH)] restent un problème majeur chez les patients porteurs du VIH (PPVIH) car chaque année de 1 à 6 % de ces patients développent des lymphomes. Ces pathologies apparaissent actuellement comme une des principales causes de mortalité chez les PPVIH.Le virus d’Epstein-Barr (EBV), connu de longue date pour son pouvoir immortalisant des lymphocytes B et les propriétés oncogènes de certaines de ses protéines, apparait comme un cofacteur favorisant plus ou moins important de ces lymphomes chez les

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17

NASCIMENTO, Janaíra da Silva. "Linfomas relacionados ao HIV em adultos atendidos na rede pública de Recife-PE." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/20000.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2017-07-24T14:40:58Z No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) LINFOMAS RELACIONADOS AO HIV EM ADULTOS ATENDIDOS NA REDE PÚ.pdf: 3190389 bytes, checksum: 7bff194ffad1d460a15b68dc1d8121ef (MD5)<br>Made available in DSpace on 2017-07-24T14:40:58Z (GMT). No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) LINFOMAS RELACIONADOS AO HIV EM ADULTOS ATENDIDOS NA REDE PÚ.pdf: 3190389 bytes, checksum: 7bff194ffad1d460a15b68dc1d8121ef (MD5)

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18

Sueur, Charlotte. "Rôle des variants de la protéine de latence LMP du virus d'Epstein-Barr dans le développement du lymphome de Hodgkin chez les personnes VIH+." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENV077/document.

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L'objectif de notre travail est de mieux comprendre le rôle de LMP1 et de ses variants délétés de 30 ou 69pb en C-terminal dans le développement du lymphome de Hodgkin (LH) chez les patients VIH+. Le séquençage de LMP1 dans des échantillons de sang total et de cellules oropharyngées de patients de la cohorte Lymphovir (LH/VIH+) et de deux populations contrôles (VIH+ et LH) a permis d'étudier la fréquence des variants de LMP1 in vivo. Ce travail a révélé que le variant LMP1-del30 semble plus fréquent chez les patients avec une immunosuppression modérée, durant laquelle l'incidence des LH est él

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19

Landgren, Ola. "Diagnostic and prognostic studies in Hodgkin's lymphoma with special reference to the elderly /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-285-x/.

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20

Patience, Lauren Alexandra. "Apoptosis-driven microenvironmental conditioning by microvesicles in non-Hodgkin lymphoma." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28710.

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Plasma membrane derived microvesicles (MV) are nanoscale particles released from cells both constitutively and in response to stimuli including stress, apoptosis and oncogenic transformation. Due to their mechanism of biogenesis, the majority of MV expose phosphatidylserine (PS) on their surface and as such can be identified by staining with annexin V (AxV). First observed nearly 40 years ago as coagulant ‘dust’ originating from activated platelets, MV were initially studied for their role in thrombosis. In more recent years it has become apparent that MV release is increased in several diseas

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21

Visentin, Andrea. "Expression and function of protein kinase CK2 in Hodgkin lymphoma." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3424905.

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Hodgkin lymphoma (HL) is a lymphoid tissue neoplasia accounting for almost 0.6% of all cancers. The neoplastic cells of Hodgkin and Reed-Sternberg cells (HRS) represent less than 1% of all the tumor bulk which is mainly composed by an heterogenous group of reactive cells of the immune system. The abnormalities of transcriptional factors and genes involved in hematopoietic cells differentiation justify the typical immunophenotype of HRS, being positive for CD30, CD15 and the immuno-checkpoint PD-L1 but usually negative for CD20. The survival of neoplastic cells is favored by the activation of N

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22

Yamamoto, Ryo. "Significance of PD-1/PD-1 ligand signaling in Hodgkin lymphoma and anaplastic large cell lymphoma." Kyoto University, 2010. http://hdl.handle.net/2433/97949.

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23

Flowers, Christopher R., Luciano J. Costa, Marcelo C. Pasquini, et al. "Efficacy of Pharmacokinetics-Directed Busulfan, Cyclophosphamide, and Etoposide Conditioning and Autologous Stem Cell Transplantation for Lymphoma: Comparison of a Multicenter Phase II Study and CIBMTR Outcomes." ELSEVIER SCIENCE INC, 2016. http://hdl.handle.net/10150/621283.

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Busulfan, cyclophosphamide, and etoposide (BuCyE) is a commonly used conditioning regimen for autologous stem cell transplantation (ASCT). This multicenter, phase II study examined the safety and efficacy of BuCyE with individually adjusted busulfan based on preconditioning pharmacokinetics. The study initially enrolled Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) patients ages 18 to 80 years but was amended due to high early treatment-related mortality (TRM) in patients > 65 years. BuCyE outcomes were compared with contemporaneous recipients of carmustine, etoposide, cytarabine, and m

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24

Gaiolla, Rafael Dezen [UNESP]. "Avaliação do nível sérico de IL-6 e IL-13 antes e após o tratamento do linfoma de Hodgkin clássico." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/95912.

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Made available in DSpace on 2014-06-11T19:27:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-08-21Bitstream added on 2014-06-13T18:56:52Z : No. of bitstreams: 1 gaiolla_rd_me_botfm.pdf: 867698 bytes, checksum: ec290cbafd254a98351e5ef8cea0e6de (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O Linfoma de Hodgkin (LH) é uma neoplasia linfóide histologicamente caracterizada pela presença de escassas células neoplásicas peculiares, denominadas células de Hodgkin/Reed-Sternberg (H-RS), em meio a infiltrado inflamatório não-neoplásico. Seu curso clínico está dire

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Gaiolla, Rafael Dezen. "Avaliação do nível sérico de IL-6 e IL-13 antes e após o tratamento do linfoma de Hodgkin clássico /." Botucatu : [s.n.], 2008. http://hdl.handle.net/11449/95912.

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Resumo: O Linfoma de Hodgkin (LH) é uma neoplasia linfóide histologicamente caracterizada pela presença de escassas células neoplásicas peculiares, denominadas células de Hodgkin/Reed-Sternberg (H-RS), em meio a infiltrado inflamatório não-neoplásico. Seu curso clínico está diretamente relacionado ao estadiamento, subtipo histológico e presença de alguns fatores prognósticos adversos já estabelecidos. Sintomas constitucionais como febre, perda de peso e sudoreses noturna, associados a um aparente desbalanço da resposta imune celular, são características comuns ao diagnóstico e denotam anormali

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26

Ziepert, Marita. "Prognosemodelle für chemotherapieinduzierte hämatologische Nebenwirkungen bei Patienten mit aggressiven Non-Hodgkin-Lymphomen." Doctoral thesis, Universitätsbibliothek Leipzig, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-62960.

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Derzeit ist es gängige Praxis, die Chemotherapie entsprechend der Körperoberfläche des Patienten zu dosieren. Diese Praxis ist jedoch nicht ideal, da es Patienten gibt, die starke Nebenwirkungen haben und andere, die kaum Nebenwirkungen aufweisen. Damit intelligentere Dosierungsschemata entwickelt werden können und prophylaktische Maßnahmen zum Verhindern von Therapienebenwirkungen besser geplant werden können, ist die Kenntnis der Faktoren erforderlich, welche die Nebenwirkungen verursachen. Die hämatologischen Nebenwirkungen der Chemotherapie sind dabei am stärksten ausgeprägt und führen oft

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27

Gisbertz, I. A. M. "Non-Hodgkin's lymphoma of the gastro-intestinal tract clinicopathological correlations /." Maastricht : Maastricht : UPM, Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=8423.

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28

Gunawardana, Jithendra. "Identification and characterization of novel recurrent mutations in primary mediastinal large B cell lymphoma and Hodgkin lymphoma." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54124.

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Classical Hodgkin lymphoma (HL) and primary mediastinal large B cell lymphoma (PMBCL) are related lymphomas sharing pathological, molecular and clinical characteristics. Here we discovered by next-generation sequencing recurrent somatic coding-sequence mutations in the protein tyrosine phosphatase PTPN1 and the cytokine receptor IL4R. Mutations in PTPN1 were found in 6 of 30 (20%) HL cases, in 6 of 9 (67%) HL–derived cell lines, in 17 of 77 (22%) PMBCL cases and in 1 of 3 (33%) PMBCL-derived cell lines, consisting of nonsense, missense and frameshift mutations. We demonstrate that PTPN1 mut

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29

Nakatani, Koya. "Roles and Limitations of FDG PET in Pediatric Non-Hodgkin Lymphoma." Kyoto University, 2012. http://hdl.handle.net/2433/157424.

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30

Müller, Anja. "Multiple outcomes for PI3K/Akt/mTOR targeting in non-Hodgkin lymphoma." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17284.

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Wachstumsfaktor bedingte Aktivierung des PI3K/Akt/mTOR Signalweg wirkt positiv auf Vermehrung und Überleben. Konstitutive Aktivierung des Signalweges in NHL ist jedoch an Tumorprogression und Therapieresistenz beteiligt. Am Zelllinienmodell wurden zwei mögliche Therapiestrategien der PI3K/Akt/mTOR Inhibition erprobt, PI3K Inhibition mit BKM120 und horizontale Kombination von Zytostatika mit PI3K/Akt/mTOR Inhibitoren Erstens, BKM120 hat Antitumoraktivität in NHL und induziert Zelltod. Auf molekularer Ebene führt BKM120 vermittelte Dephosphorylierung von CDK1 an Y15 zur Aktivierung des M-Phase

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Silva, Glenda Nicioli da [UNESP]. "Avalição de polimorfismos de nucleotídeos simples (SNPs) na região promotora de gene da interleucina 10 em pacientes com Linfoma de Hodgkin." Universidade Estadual Paulista (UNESP), 2004. http://hdl.handle.net/11449/95913.

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Made available in DSpace on 2014-06-11T19:27:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2004Bitstream added on 2014-06-13T20:36:39Z : No. of bitstreams: 1 silva_gn_me_botfm.pdf: 467036 bytes, checksum: 3b9fa526eae390b7ae86bf47c5bcf731 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O linfoma de Hodgkin (LH) tem características clínicas e anátomo-patológicas distintas dos linfomas não-Hodgkin. Seu componente neoplásico, as células células de Hodgkin/Reed-Sternberg (H-RS), corresponde a cerca de 2% do tumor. As células H-RS apresentam imunofenótipo peculiar

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Santos, Lucas Vieira dos 1981. "Radioterapia para linfoma não-Hodgkin agressivo e localizado : revisão sistemática da literatura com meta-análise." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313865.

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Orientadores: Andre Deeke Sasse, Carmen Silvia Passos Lima<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-24T04:20:53Z (GMT). No. of bitstreams: 1 Santos_LucasVieirados_M.pdf: 843952 bytes, checksum: bd8daf1913e68951fafe63ae91e9b070 (MD5) Previous issue date: 2013<br>Resumo: Introdução: O linfoma não-Hodgkin é o sexto grupo de neoplasias em mortalidade no mundo. Quando em estágio precoce, o linfoma não-Hodgkin pode ser curado com quimioterapia. A radioterapia tem sido utilizada para se reduzir a recorrência

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Kriel, Magdalena. "Clinical-pathological characterisation of children with B-cell non-Hodgkin lymphoma over a ten year period at a tertiary centre in Cape Town." Master's thesis, Faculty of Health Sciences, 2020. http://hdl.handle.net/11427/32711.

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Background: We characterized B-cell non-Hodgkin lymphoma (NHL) cases over ten years at a tertiary children's hospital to contribute to the body of knowledge on pediatric lymphoma in developing countries with a high human immunodeficiency virus (HIV) burden. Methods: A retrospective cohort study using clinical and laboratory records of children newly diagnosed with B-cell NHL from January 2005 to December 2014. Results: Seventy-five children ≤ 15 years were included. The majority had Burkitt lymphoma (n = 61). Twenty-five percent (n = 19) were HIV positive and 16% (n = 12) had concurrent active

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Li, Ziduo. "Evaluation of anti-CD83 monoclonal antibodies for the diagnosis and treatment of Hodgkin lymphoma and mantle cell lymphoma." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23923.

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Lymphoma affects approximately 6400 Australians yearly and can develop in people of all ages. Monoclonal antibodies that target specific antigens have been shown effective in lymphomas but resistance occurs. Scientists have sought for novel therapeutical targets for lymphomas. CD83 is a member of the immunoglobulin superfamily. To date, the main utility of CD83 is to identify the activated dendritic cells. Our group described the CD83 expression by a malignant lymphoma cell line, KM-H2, more than 20 years ago. In this thesis, I examined the potential of CD83 as a therapeutic target for two sub

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35

Fatima, Zainab, Haroon Rahman, Sonia Kumari Oad, Elnora Spradling, and Devapiran Jaishankar. "Lymphoma at First Sight: A Rare Case of Mantle Cell Lymphoma Presenting as Isolated Periorbital Swelling." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/26.

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Mantle cell lymphoma (MCL) represents a heterogenous subtype of non-Hodgkin lymphoma (NHL), which can present in three distinct clinicopathologic variants: indolent type MCL, classic type MCL and blastoid type MCL. Despite the different variations, MCL, in general, is almost always associated with advanced-stage disease at diagnosis, with a strong predilection for significant extranodal involvement, usually to the bone marrow, CNS, peripheral blood and the gastrointestinal tract. However, the literature review reveals ocular involvement is a more rarely described extranodal site of involvement

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Aggarwal, Mohit. "Biological pathways in B-cell non-Hodgkin's lymphoma." Stockholm : Department of Medicine, Karolinska Institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-739-9/.

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37

Kolk, Lizetta Elisabeth van der. "CD20 monoclonal antibody therapy for B-cell lymphoma." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/58282.

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Gil, Veronica Sylvina. "The role of histone deacetylase 9 in b-cell non-hodgkin lymphoma." Thesis, Institute of Cancer Research (University Of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533649.

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Burton, Catherine Helen. "Immunophenotypic and genetic characterisation of neoplastic B-cells in classical Hodgkin lymphoma." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612159.

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Swart, Luhan. "HIV-associated Hodgkin lymphoma at Groote Schuur Hospital, Western Cape, South Africa." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/27282.

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Background: Human immunodeficiency virus (HIV) is associated with an increased risk of developing Hodgkin lymphoma (HL). South Africa (SA) has the highest HIV prevalence rate in the world. There is currently no 5-year overall survival (OS) outcome based data for HIV-associated HL from SA. Methods: A bone marrow database was compiled of all bone marrow biopsies (BMB) reported at National Health Laboratory Service (NHLS) Groote Schuur Hospital (GSH) between January 2005 and December 2012. Patients who had a BMB performed for staging of HL or where HL was diagnosed on the BMB were included for fu

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Achkova, Daniela Yordanova. "Development of immunotherapy for classical Hodgkin lymphoma and anaplastic large cell lymphoma using CSF1R re-targeted human T-lymphocytes." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/development-of-immunotherapy-for-classical-hodgkin-lymphoma-and-anaplastic-large-cell-lymphoma-using-csf1r-retargeted-human-tlymphocytes(6c8f3741-fa95-472b-a542-af2b8a7f2618).html.

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Classical Hodgkin’s lymphoma (cHL) represents the most common subtype of malignant lymphoma in young people in the Western world. Despite modern treatment strategies, about 20% of patients still die due to relapse or progressive disease. Anaplastic large cell lymphoma (ALCL) is a type of T/null-cell lymphoma that represents about 20-30% of paediatric lymphomas and has an aggressive clinical course with frequent relapse. Recently, high-level expression of CSF-1R on malignant cells in cHL and ALCL has been linked to shorter progression free survival, providing a rationale to test adoptive CSF-1R

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Berger, Garrett, Stephanie Lawson, and Kelsey Royball. "Brentuximab Vedotin for Treatment of Non-Hodgkin Lymphomas: A Systematic Review." The University of Arizona, 2017. http://hdl.handle.net/10150/624029.

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Class of 2017 Abstract<br>This project is related to the article that was later published, available at this link: https://doi.org/10.1016/j.critrevonc.2016.11.009<br>Objectives: Brentuximab vedotin (BV) is an antibody-drug conjugate comprising a CD30-directed antibody conjugated to the microtubule-disrupting agent MMAE via a protease cleavable linker. BV is FDA approved for use in relapsed classical Hodgkin lymphoma and relapsed systemic Methods: primary study outcomes being objective response rate. PubMed (1946-2015), EMBASE (1947-2015), and Cochrane Central Register of Controlled Trials

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Viana, Daniel de AraÃjo. "Polimorfismos do gene TP53 no linfoma de Hodgkin." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=3202.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>FundaÃÃo de Amparo Ã Pesquisa do Estado do CearÃ<br>O Linfoma de Hodgkin Ã uma hemopatia linfÃide pode ocorrer em qualquer faixa etÃria; no entanto, Ã mais comum na idade adulta jovem, dos 15 aos 40 anos. O TP53 Ã um gene de 20kb de comprimento que possui 11 Ãxons situado no cromossomo 17 e codifica a proteÃna p53, uma proteÃna cuja principal funÃÃo estÃ relacionada Ã preservaÃÃo da integridade do cÃdigo genÃtico, e, durante o ciclo celular faz verificaÃÃo quanto Ã eventual ocorrÃncia de uma mutaÃÃo na seqÃÃncia do cÃdig

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Tawadros, Fady, Sakshi Singal, Maria Zayko, and Devapiran Jaishankar. "Mucosal Associated Lymphoid tissue of the Skin, A Common Entity in a Rare Location." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/55.

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Marginal zone (MZ) lymphomas (MZLs) represent a group of lymphomas originating from B lymphocytes of the “marginal zone” which is the external part of the secondary lymphoid follicles. The WHO classifies MZL into 3 entities; extranodal MZL, splenic MZL and nodal MZL. Extranodal marginal zone lymphoma (EMZL) can arise in different tissues, including the stomach, salivary gland, lung, small bowel, thyroid, ocular adnexa and skin. We present a 25 years old female with a history of angioedema and chronic cutaneous eczema who developed an unusual EMZL. Patient presented with a history of rapidly en

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Díaz, Sánchez Tania. "JAK2 en el linfoma de Hodgkin: Impacto pronóstico de la regulación mediada por miR-135a y análisis in vitro de Lestaurtinib." Doctoral thesis, Universitat de Barcelona, 2011. http://hdl.handle.net/10803/32005.

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El linfoma de Hodgkin es una neoplasia de células B caracterizada por la escasa presencia de células tumorales, células de Hodgkin/Reed-Sternberg, localizadas en un microambiente no tumoral. El comportamiento del LH se determina por las características intrínsecas de las células HRS y por las características de las células inflamatorias no neoplásicas del microambiente. Por eso, el análisis del papel pronóstico que juegan los miRNAs en el ganglio completo y no únicamente en las células tumorales adquiere un gran significado. La vía JAK/STAT es una vía de señalización utilizada por muchas c

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Silva, Glenda Nicioli da. "Avalição de polimorfismos de nucleotídeos simples (SNPs) na região promotora de gene da interleucina 10 em pacientes com Linfoma de Hodgkin /." Botucatu : [s.n.], 2004. http://hdl.handle.net/11449/95913.

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Orientador: Maura Moscardi Bacchi<br>Resumo: O linfoma de Hodgkin (LH) tem características clínicas e anátomo-patológicas distintas dos linfomas não-Hodgkin. Seu componente neoplásico, as células células de Hodgkin/Reed-Sternberg (H-RS), corresponde a cerca de 2% do tumor. As células H-RS apresentam imunofenótipo peculiar e sua origem ainda é objeto de estudo. O LH é classificado em LH clássico (que inclui os subtipos celularidade mista, esclerose nodular, depleção linfocítica e LH rico em linfócitos) e LH predominância linfocítica nodular. A associação do vírus de Epstein-Barr (EBV) com LH é

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Emanuele, Cencini. "Study of gene polymorphisms as predictors of treatment efficacy and toxicity in patients with indolent non-Hodgkin lymphomas and mantle-cell lymphoma receiving bendamustine and rituximab." Doctoral thesis, Università di Siena, 2018. http://hdl.handle.net/11365/1048374.

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Introduction: indolent non-Hodgkin lymphomas (iNHL) and mantle-cell lymphoma (MCL) have a heterogeneous behavior, impacted by biological and clinical parameters. Bendamustine is widely used in association with rituximab (BR) to treat iNHL and MCL. The variability in treatment efficacy and toxicity could be related to germline single nucleotide polymorphisms (SNPs) in immune and inflammatory response genes. Methods: we would like to show a possible association between SNPs and treatment outcome in iNHL and MCL patients receiving BR regimen. We have investigated some SNPs that have already bee

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Burroni, Barbara. "Caractérisation du microenvironnement tumoral dans le lymphome de Hodgkin classique par technologie spatiale in situ : identification de sous groupes tumoraux et implications thérapeutiques." Electronic Thesis or Diss., Sorbonne université, 2025. http://www.theses.fr/2025SORUS040.

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Le lymphome de Hodgkin classique (cHL) est une forme unique d'hémopathie lymphoïde, caractérisée par de cellules tumorales dites de Reed-Sternberg (RS), dispersées dans un microenvironnement polymorphe et abondant. Les cellules de RS présentent une répression du programme des cellules B et une production défectueuse d'immunoglobulines. Les individus plus jeunes sont affectés aussi que les sujets âgés, ce qui induit un profil particulier d'incidence bimodale. Le virus d'Epstein-Barr (EBV) est à la fois un facteur de risque et un puissant moteur de la lymphomagenèse dans un sous-ensemble de cas.

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Dhalla, Anar. "Interactions between cytochrome P450 genetic polymorphisms and plasma organochlorines in non-Hodgkin lymphoma." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50041.

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Following World War II, the production of chlorine-containing organic molecules known as organochlorines (OCs) became commonplace. Although heightened regulation has since occurred in Canada, OCs continue to pose health and environmental concerns due to their persistence and ongoing use elsewhere. To date, the largest study assessing the association between plasma OCs and non-Hodgkin lymphoma (NHL) was conducted in British Columbia (BC) between 2000 and 2004. Eight hundred twenty-eight newly diagnosed NHL cases were ascertained from the BC Cancer Registry and 848 population controls were rando

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Yang, Fan. "Early diagnosis of Fusarium Infection and Biomarker of susceptibility in Non-Hodgkin Lymphoma." Paris 7, 2014. http://www.theses.fr/2014PA077239.

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PARTIE 1 : Nous rapportons les caractéristiques cliniques et pathologiques de deux patients d'une infection à Fusarium. Les biopsies cutanées précoces montraient l'implication des microvaisseaux avec des hyphes et de la thrombose. L'infection à Fusarium a été confirmée par la culture de la peau. La présence des hyphes au sein de thrombus des microvaisseaux cutanés étaient très évocatrice d'une infection fongique disséminée. Dans des biopsies cutanées précoces de patients immunodéprimés, la présence d'une thrombose vasculaire suggère un diagnostic précoce d'une infection fongique et peut aider

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