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Journal articles on the topic 'Hodgkin lymphoma'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Mugabe Byiringiro, Fiacre, Felix Manirakiza, Déogratias Ruhangaza, Thierry Zawadi Muvunyi, and Belson Rugwizangoga. "Pathology Characteristics of Lymphomas in Rwanda: A Retrospective Study." East African Health Research Journal 5, no. 2 (2021): 170–73. http://dx.doi.org/10.24248/eahrj.v5i2.669.

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Background: Lymphomas have been a global challenge for many decades and despite measures for prevention and management, the incidence continues to increase. There are two main categories, which are Non-Hodgkin’s Lymphomas and Hodgkin’s Lymphomas and most common etiologies are environmental, genetic alteration, radiation and some viruses. Objective: To describe pathology characteristics of lymphomas in Rwanda based on Hematoxylin and Eosin stained glass slides and immuno histo chemistry, and classify them according to clinical aggressiveness. Patients and Methods: We conducted a retrospective o

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Singh, Vikram, Pratiksha Hada, Sakshi Sharma, and Shivam Dubey. "Intraoral Swelling: A Rare Case Report with Diagnostic Perplexity." Journal of Indian Academy of Oral Medicine and Radiology 36, no. 2 (2024): 181–83. https://doi.org/10.4103/jiaomr.jiaomr_167_23.

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Abstract Non-Hodgkin lymphomas are malignant tumor that arises from the lymphoreticular system. Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma distinguished by the proliferation of pleomorphic large lymphoid cells expressing CD30 antigen. This case report is about a 55-year-old patient who had pain and swelling in her lower front teeth region. The immunohistochemistry report confirmed the diagnosis of high-grade non-Hodgkin’s lymphoma of the anaplastic null cell type.

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Manzella, Adonis, Paulo Borba-Filho, Giuseppe D'Ippolito, and Marcella Farias. "Abdominal Manifestations of Lymphoma: Spectrum of Imaging Features." ISRN Radiology 2013 (September 2, 2013): 1–11. http://dx.doi.org/10.5402/2013/483069.

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Non-Hodgkin and Hodgkin lymphomas frequently involve many structures in the abdomen and pelvis. Extranodal disease is more common with Non-Hodgkin’s lymphoma than with Hodgkin's lymphoma. Though it may be part of a systemic lymphoma, single onset of nodal lymphoma is not rare. Extranodal lymphoma has been described in virtually every organ and tissue. In decreasing order of frequency, the spleen, liver, gastrointestinal tract, pancreas, abdominal wall, genitourinary tract, adrenal, peritoneal cavity, and biliary tract are involved. The purpose of this review is to discuss and illustrate the sp

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Ahmed, Mahtab Uddin, and Harun-Or-Rashid Khan Shilpi. "Significance of Immunohistochemistry in Accurate Characterisation of Hodgkin Lymphoma." Journal of Enam Medical College 5, no. 1 (2015): 23–29. http://dx.doi.org/10.3329/jemc.v5i1.21493.

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Background: Hodgkin lymphomas are malignant disorders of cells residing in lymphoid tissue and containing Reed-Sternberg (RS) cells and its variants and account for about 0.7% of all new cancers. Hodgkin lymphomas are two types: Classical Hodgkin lymphoma (CHL) that is CD30 positive and CD45 negative in specific pattern; Lymphocyte-predominant Hodgkin lymphoma (LPHL) that is CD30 negative and CD45 positive in specific pattern. Objective: To evaluate the value of immunohistochemistry in the diagnosis and accurate characterisation of Hodgkin lymphoma. Materials and Methods: This cross-sectional

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5

Montes-Moreno, S. "Hodgkin's Lymphomas: A Tumor Recognized by Its Microenvironment." Advances in Hematology 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/142395.

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Thomas Hodgkin's and Samuel Wilks first recognized Hodgkin disease in the first half of the 19th century. Initially described as lymphogranulomatosis, it was later recognized to be a lymphoid neoplasm derived from B cells and was classified on the basis of its histopathological features. Hodgkin lymphomas are now regarded as encompassing two clearly defined entities according to the WHO classification: nodular lymphocyte-predominant Hodgkin Lymphoma (NLPHL) and classical Hodgkin Lymphoma (CHL). This paper focuses on the current knowledge about the biological features that characterize both NLP

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Yadav, Geeta, Anurag Singh, Mili Jain, Rashmi Kushwaha, and Shailendra Prasad Verma. "Reed Sternberg-Like Cells in Non-Hodgkin Lymphoma: A Diagnostic Challenge." Discoveries 10, no. 3 (2022): e155. http://dx.doi.org/10.15190/d.2022.14.

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Reed-Sternberg cells are distinguishing features of classical Hodgkin lymphoma. However, they are seen infrequently, in both B and T cells NonHodgkin lymphomas with a comparable morphology and immunophenotype. These cells are known as Reed-Sternberg-like cells. The characteristic background milieu of classical Hodgkin lymphoma is typically not present in Non-Hodgkin lymphomas, and Reed-Sternberg-like cells are typically present as dispersed cells or in tiny clusters. They are positive for CD30, show variable expression of B cell lineage markers and are negative for CD45/LCA in Non-Hodgkin lymp

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Sumoza, Luis D., Jeffrey L. Jorgensen, and Ilia R. Sumoza. "Composite Nodular Sclerosis Hodgkin and Diffuse Large B Cell Non-Hodgkin Lymphoma Arising from the Thymus." Blood 110, no. 11 (2007): 4432. http://dx.doi.org/10.1182/blood.v110.11.4432.4432.

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Abstract We report the first case of composite Nodular Sclerosis Hodgkin and Diffuse Large B-Cell Non-hodgkin’s lymphoma of the mediastinum. We present a case of an inmunocompetent patient operated on for a mediastinal tumor similar to a Thymoma, which the histological examination morphological, and immunophenotyping were performed and confirmed the existence of 2 independent, unrelated tumors. The pathology blocks submitted show a composite lymphoma, with components of both classical Hodgkin lymphoma (Hodgkin’s disease), nodular sclerosis type, grade 2 of 2 in all three blocks. One block also

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Ahn, Ji Yong. "Gastrointestinal Tract Lymphoma." Korean Journal of Helicobacter and Upper Gastrointestinal Research 22, no. 1 (2022): 18–28. http://dx.doi.org/10.7704/kjhugr.2021.0064.

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The gastrointestinal tract is the most common site of extranodal lymphoma, and more than 95% of gastrointestinal lymphoma cases are of the non-Hodgkin type. The stomach is the primary site of extranodal non-Hodgkin lymphoma, and more than 98% of primary gastric lymphoma (PGL) cases are diffuse large B-cell lymphomas (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphomas. Because PGL usually presents with nonspecific clinical symptoms and various endoscopic features, its diagnosis is mainly dependent on histopathologic findings. Chemotherapy is the first-line treatment choice for gastri

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Bansal, Rimpi, Puneet Kaur, Jatin Sarin, Anureet Kaur, and Akshita Sarin. "Incidence and Prognostic Implication of Bone Marrow Involvement in Hodgkin’s Lymphoma." Annals of Pathology and Laboratory Medicine 8, no. 11 (2021): A239–242. http://dx.doi.org/10.21276/apalm.3010.

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Introduction- : Conducting Bone marrow examination in a Hodgkin's Lymphoma (HL) patient at the time of diagnosis is done routinely to determine the stage of the disease. The aim of this study was to analyze the incidence and prognosis of bone marrow involvement in patients with Hodgkins lymphoma, retrospectively. Materials and Patients: Ten patients of Hodgkins lymphoma were incorporated in the current study. Bone marrow aspiration and biopsy was done in all ten cases as part of staging procedure. Results: Three patients showed involvement of bone marrow by Hodgkin’s lymphoma and b

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10

Chen, Ling, Yaling Yang, C. Cameron Yin, et al. "Aberrant Expression of Golgin-84 in Non-Hodgkin Lymphomas and Plasma Cell Myeloma." Blood 118, no. 21 (2011): 4633. http://dx.doi.org/10.1182/blood.v118.21.4633.4633.

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Abstract Abstract 4633 Background: Golgins are proteins of the Golgi complex. Several Golgins have been implicated in apoptosis. Expression of Golgin-84, a Golgin protein, is altered in apoptotic WEHI-231, a B-cell lymphoma line, suggesting that Golgin-84 may play a role in lymphoid tumorigenesis. Here, we aimed to determine the expression levels of Golgin-84 in human primary non-Hodgkin lymphomas and plasma cell myeloma. Design: Golgin-84 expression was investigated in non-Hodgkin lymphoma cell lines by using Western blot analysis and polyclonal antibodies. Using immunohistochemical stains, W

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Barukčić, Ilija. "Without Epstein Barr virus infection, no non Hodgkin lymphoma." Causation 17, no. 12 (2022): 5——131. https://doi.org/10.5281/zenodo.6791972.

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<strong>Background.</strong> Lymphomas are  tumours of the immune system.  About 10 % of all lymphomas are Hodgkin's lymphoma, while the remaining 90 % are referred to as non-Hodgkin lymphoma. The cause or even a cause of non-Hodgkin lymphoma is still not identified. <strong>Methods.</strong> View studies which investigated the relationship between Epstein-Barr virus  and non-Hodgkin lymphoma have been re-analysed. <strong>Results.</strong> <strong>Without</strong> Epstein-Barr virus infection, <strong>no</strong> non-Hodgkin lymphoma (P Value = 0,0191030137). <strong>Conclu

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SAK, Adil, Sathya M, Vani D, and Nisarga MD. "Evaluation of epidemiological features and immunohistochemical profile of non-Hodgkin's lymphoma in a tertiary referral hospital." Journal of Medical and Scientific Research 13, no. 1 (2025): 12–19. https://doi.org/10.17727/jmsr.2024/13-3.

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Background: Non-Hodgkin lymphoma (NHL) represents a diverse group of malignancies of lymphoid tissue due to clonal proliferation of lymphoid cells. India has a notable distribution of NHL, but its characterization and description are still insufficient. The objective of this study was to evaluate the epidemiological features and immunohistochemical profile of NHL in patients attending a tertiary referral hospital. Material and methods: This study is a descriptive analysis of cases patients diagnosed with NHL referred to the Department of Oncology at a tertiary referral hospital in South India.

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Hartmann, Sylvia, Sonja Scharf, Yvonne Steiner, et al. "Landscape of 4D Cell Interaction in Hodgkin and Non-Hodgkin Lymphomas." Cancers 13, no. 20 (2021): 5208. http://dx.doi.org/10.3390/cancers13205208.

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Profound knowledge exists about the clinical, morphologic, genomic, and transcriptomic characteristics of most lymphoma entities. However, information is currently lacking on the dynamic behavior of malignant lymphomas. This pilot study aimed to gain insight into the motility of malignant lymphomas and bystander cells in 20 human lymph nodes. Generally, B cells were faster under reactive conditions compared with B cells in malignant lymphomas. In contrast, PD1-positive T cells did not show systematic differences in velocity between reactive and neoplastic conditions in general. However, lympho

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K., Singh, Demeter Z., and Kumar P. "Follicular Lymphoma in Companion Animals." International Journal of Veterinary Health Science & Research 3, no. 2e (2015): 1. https://doi.org/10.19070/2332-2748-150004e.

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Lymphoma is an enigmatic and fascinating disease complex that involves almost all vertebrates and can be of B, T, or NK cell of origin. More than 70% of canine lymphomas are of B cell origin. Since the discovery of Hodgkin’s lymphoma by an anatomist Thomas Hodgkin in 1832, all malignant lymphomas in humans were characterized as either Hodgkin lymphoma or non-Hodgkin lymphoma at the beginning of the twenty-first century [2]. Follicular lymphomas (FL) are the common subtype of non-Hodgkin lymphoma in humans and are associated with an indolent i.e, sl

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Tran, Quang Trung, Thinh Nguyen Duy, Bao Song Nguyen-Tran, et al. "Endoscopic and Histopathological Characteristics of Gastrointestinal Lymphoma: A Multicentric Study." Diagnostics 13, no. 17 (2023): 2767. http://dx.doi.org/10.3390/diagnostics13172767.

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Background: Extranodal non-Hodgkin lymphoma (NHL) is more prevalent in the gastrointestinal (GI) tract than in other sites. This study aimed to determine the endoscopic characteristics of primary gastrointestinal non-Hodgkin lymphomas. Methods: We investigated 140 patients from three tertiary referral hospitals with primary malignant lymphoma of the gastrointestinal tract. Characteristics of the lesions were evaluated and analyzed using image-enhanced endoscopy, endoscopic ultrasound, and histopathology. Results: The median age was 60.5 (range: 11–99), and 59 (42.1%) were female. The most freq

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Satya Prasad M.D., V., Pranaya Vana (M.D.), Vaddi Harshitha (M.D.), and Vaishnavi Karnatapu (M.D.). "A CASE OF HODGKIN LYMPHOMA PRESENTING AS NEPHROTIC SYNDROME." International Journal of Advanced Research 10, no. 12 (2022): 910–15. http://dx.doi.org/10.21474/ijar01/15922.

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Paraneoplastic glomerulopathy has been reported in patients with malignancy.In particular, the association of Nephrotic Syndrome (NS) with Hodgkins Lymphoma (HL) is rare and there are few reports in the literature. Minimal change nephropathy is the most frequently observed renal lesion whereas this association appears, either simultaneously or within several months of each other. Nephrotic changes as part of the paraneoplastic syndrome are rare in lymphoid malignancies. 1% of cases of Hodgkins Lymphoma cases may present with nephrotic syndrome. We are reporting a case which initially presented

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Fernández-Rañada de la Gándara, J. M. "Hodgkin Lymphoma (HL) a success story over 50 years." ANALES RANM 139, no. 139(01) (2022): 88–99. http://dx.doi.org/10.32440/ar.2022.139.01.rev07.

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Hodgkin Lymphoma (HL) is a rare B-origin lymphoma that accounts for approximately 10% of all lymphomas. HL is made up of two different entities: on the one hand, the Classical Hodgkin Lymphoma (CHL), consisting of the histological forms of predominantly lymphocytic, nodular sclerosis, mixed cellularity and lymphocytic depletion and, on the other, the Nodular Lymphocyte-Predominant Hodgkin Lymphoma (NLPHL). During the last 50 years, we have seen a move from a monovalent therapy – with a 5-10% survival probability at 5 years – to a combination chemotherapy and a therapeutic approach aimed at red

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18

da Silva, Glenda Nicioli, Maura Moscardi Bacchi, Cláudia Aparecida Rainho, and Deilson Elgui de Oliveira. "Epstein-Barr Virus Infection and Single Nucleotide Polymorphisms in the Promoter Region of Interleukin 10 Gene in Patients With Hodgkin Lymphoma." Archives of Pathology & Laboratory Medicine 131, no. 11 (2007): 1691–96. http://dx.doi.org/10.5858/2007-131-1691-eviasn.

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Abstract Context.—Hodgkin lymphoma is a neoplastic disease in which the immune system plays a major role in its pathogenesis. Interleukin 10 (IL-10), an immunosuppressive cytokine actively produced in patients with Hodgkin lymphomas, favors the survival of the Hodgkin/Reed-Sternberg cells. Individual variations in IL-10 levels may be due, in part, to the presence of single nucleotide polymorphisms in the IL10 gene promoter. Objective.—To evaluate whether particular single nucleotide polymorphisms in the IL10 gene are found more frequently in Hodgkin lymphoma cases associated with Epstein-Barr

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Leventhal, Brigid G., and Gregory J. Kato. "Childhood Hodgkin and Non-Hodgkin Lymphomas." Pediatrics In Review 12, no. 6 (1990): 171–79. http://dx.doi.org/10.1542/pir.12.6.171.

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Lymphomas were recognized originally by Virchow as swellings of lymph nodes that were unrelated to tuberculosis or to other recognized pathology in the drainage area of the lymph node group. Lymphomas were not recognized initially as malignancies; proof of this came only in this century. Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL), which together account for approximately 12% of childhood cancer, have become among the most curable of pediatric malignancies. Today, the projected cure rates for children in certain categories are as high as 90%. Recent advances in molecular biology have

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Li, Pei-Chuan, Imran N. Siddiqi, Eric Y. Loo, et al. "Monoamine Oxidase a (MAO A) Is Expressed Selectively in Reed-Sternberg Cells of Classical Hodgkin Lymphoma." Blood 126, no. 23 (2015): 3864. http://dx.doi.org/10.1182/blood.v126.23.3864.3864.

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Abstract Monoamine oxidase A (MAO A) is a mitochondrial enzyme, which catalyzes oxidative deamination of neurotransmitters or dietary amines and produces H2O2. Recent work indicates that MAO A is overexpressed in prostate cancer. Inhibiting its activity suppresses tumorigenesis and metastasis. In this study, we showed that Hodgkin lymphoma (HL)-derived L1236 cells express high MAO A activity, while other human lymphoma cell lines examined, including both Hodgkin and non-Hodgkin lymphoma, do not express MAO A. We also analyzed MAO A expression by immunohistochemistry in formalin-fixed paraffin-

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Raina, Devisha. "Rare case of gastric extranodal marginal zone lymphoma." International Surgery Journal 8, no. 4 (2021): 1316. http://dx.doi.org/10.18203/2349-2902.isj20210992.

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True histiocytic lymphoma is considered a rare entity, and its diagnosis requires the concordance of morphological, immunophenotypic, and molecular findings. Gastric extra nodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) is a B-cell non-Hodgkin lymphoma that arises in the stomach and has a perifollicular/marginal zone growth pattern. The lymphoma is derived from marginal zone B-cells and recapitulates the architecture and organization of native MALT exemplified by the Peyers’ patches in the terminal ileum. Marginal zone lymphoma of MALT (MALT lymphoma) is the mos

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Ilanthodi, Sandhya, Samridhi Hegde, Prithal G, Reba T. Phillipose, and Girish P N. "Unveiling the journey of diagnosing cutaneous lymphomas- A case series." IP Archives of Cytology and Histopathology Research 7, no. 2 (2022): 142–46. http://dx.doi.org/10.18231/j.achr.2022.031.

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Cutaneous manifestation of Non-Hodgkin lymphoma can histologically and clinically manifest as Mycosis fungoides or Vasculitis. Histopathologic features of cutaneous lymphoma show dense tumor with a “bottom heavy” configuration. Tumor comprises either large lymphoid cells or sheets of monotonous small lymphoid cells with plasmacytoid configuration. A detailed work up is mandatory to conclude the diagnosis and provide definitive treatment in cutaneous lymphomas. In our case series, we present and describe 5 cases of Non-Hodgkin lymphoma with cutaneous manifestations. Two cases of Angioimmunoblas

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Xie, Linka, Alexey Ushmorov, Frank Leithäuser, et al. "FOXO1 is a tumor suppressor in classical Hodgkin lymphoma." Blood 119, no. 15 (2012): 3503–11. http://dx.doi.org/10.1182/blood-2011-09-381905.

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Abstract The FOXO transcription factors control proliferation and apoptosis in different cell types. Their activity is regulated by posttranslational modifications, mainly by the PI3K-PKB pathway, which controls nuclear export and degradation. We show that FOXO1 is highly expressed in normal germinal center B cells as well as in non-Hodgkin lymphomas, including follicular lymphoma, diffuse large B-cell lymphoma, mucosa-associated lymphoid tissue non-Hodgkin lymphoma, B-cell chronic lymphocytic leukemia, and mantle cell lymphoma. In contrast, in 31 of 32 classical Hodgkin lymphoma (cHL) cases,

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Shupletsova, I. A., and A. M. Kovrigina. "The characterization and frequency of diagnosis of EBV-positive variants with a lymphoid predominance in the structure of Hodgkin lymphoma." Russian journal of hematology and transfusiology 66, no. 4 (2021): 567–79. http://dx.doi.org/10.35754/0234-5730-2021-66-4-567-579.

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Introduction. Epstein — Barr virus (EBV) plays an important role in the pathogenesis of lymphoid tumors, in particular Hodgkin lymphoma. The frequency of expression of the EBV varies in different histological variants of classical Hodgkin lymphoma and is rarely observed in nodular lymphocyte predominant Hodgkin lymphoma.Aim — to study the pathomorphological features of the histological variants of Hodgkin lymphoma with lymphoid predominance associated with the EBV, as well as the frequency of their diagnosis in the structure of Hodgkin lymphoma.Materials and methods. The retrospective study in

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Perez, Maria T., Beria Cabello-Inchausti, Amilcar Castellano-Sanchez, et al. "Primary Gastroesophageal-Ileal Hodgkin Lymphoma." Archives of Pathology & Laboratory Medicine 126, no. 12 (2002): 1534–37. http://dx.doi.org/10.5858/2002-126-1534-pgihl.

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Abstract Primary Hodgkin lymphoma of the gastrointestinal tract is exceedingly rare to the point that some authors regard with skepticism the existence of this entity. Cases of gastrointestinal Hodgkin lymphoma have been reported previously; however, most of these cases represented secondary involvement of the digestive tract in the context of systemic disease. Other cases have been reclassified in retrospective studies as non-Hodgkin lymphomas after the application of immunohistochemical techniques. We report a case of primary Hodgkin lymphoma of the gastrointestinal tract in a patient who pr

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Marić, Daliborka, Dragan Stojanov, Saša Vujnović, and Violeta Kovačević Dragosavljević. "A Rare Case of Primary Breast Mucosa- Associated Lymphoid Tissue Lymphoma." Acta Facultatis Medicae Naissensis 33, no. 4 (2016): 313–18. http://dx.doi.org/10.1515/afmnai-2016-0033.

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Abstract Breast involvement by lymphoma is uncommon and poses challenges in diagnosis. Breast involvement by malignant lymphoma, whether primary or secondary, is a rare event. Primary breast lymphomas account for 0.38% - 0.7% of all non-Hodgkin lymphomas, 1.7%-2.2% of all extranodal non-Hodgkin lymphomas, and only 0.04% - 0.5% of all breast cancer cases. Most frequent primary breast lymphomas are diffuse large B cell lymphomas (53%). Breast mucosa-associated lymphoid tissue (MALT) lymphomas account for a small fraction of all the MALT lymphomas (1% - 2%). Herein we report a case of a patient w

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Chaudhry, Sunil, Abhijit Trailokya, and Manoj Naik. "Novel therapeutics for Hodgkin\'s lymphoma." Southeast Asian Journal of Health Professional 7, no. 1 (2024): 1–5. http://dx.doi.org/10.18231/j.sajhp.2024.001.

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Hodgkins LymphomaHL) was first described by Thomas Hodgkin in 1832., is a malignant disorder, a rare B cell lymphoma (mutant lymphocytes) with reasonable outcome due to the fair cure rates achieved by modern chemotherapy and/or radiotherapy. The incidence of HL is 2.6 cases per 100,000 people, accounts for 10% lymphoma cases. The Epstein–Barr virus (EBV) is detected in nearly 45% of HL patients Most of the affected patients are between ages 20 to 40 years. HL is uncommon in children &#60; 5 years of age. The Reed-Sternberg (RS), large cells 50 micrometers in diameter which secrete cytokine

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Voicu, Dragos, Constantin Volovat, Simona Ruxandra Volovat, et al. "Primitive Gastric Lymphoma - a Series of 3 Cases." Revista de Chimie 71, no. 1 (2020): 416–19. http://dx.doi.org/10.37358/rc.20.1.7868.

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The Primitive Gastric Lymphoma represents the extra-ganglionic non-Hodgkin lymphoma most frequently and comprises a large spectrum, ranging from the mucosa-associated lymphoid tissue (MALT) lymphoma to aggressive diffuse large B-cell lymphoma. The Primitive Gastric Lymphoma is a rare tumor, with an occurrence ranging from 4% to 20% of non-Hodgkin lymphomas and approximatively 5% of primary gastric neoplasms. The chronic gastritis secondary to the infection with Helicobacter pylori was considered a major predisposing factor for MALT lymphoma. The clinical evolution and the prognosis of this dis

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Lohri, Andreas. "Lymphome." Praxis 105, no. 1 (2016): 47–52. http://dx.doi.org/10.1024/1661-8157/a002237.

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Zusammenfassung. Maligne Lymphome unterteilen sich zwar in über 60 Entitäten, das grosszellige B-Zell-Lymphom, das follikuläre Lymphom, der Hodgkin und das Mantelzell-Lymphom machen aber mehr als die Hälfte aller Lymphome aus. Im revidierten Ann Arbor staging system gelten die Suffixe «A» und «B» nur noch für den Hodgkin. «E» erscheint nur noch bei Stadien I und II. Eine Knochenmarksuntersuchung wird beim Hodgkin nicht mehr verlangt, beim DLBCL (Diffuse large B cell lymphoma) nur, falls das PET keinen Knochenmark-Befall zeigt. Der PET-Untersuchung, speziell dem Interim-PET, kommt eine entschei

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Topalovski, Margarita, Domnita Crisan, and Joan C. Mattson. "Lymphoma of the Breast." Archives of Pathology & Laboratory Medicine 123, no. 12 (1999): 1208–18. http://dx.doi.org/10.5858/1999-123-1208-lotb.

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Abstract Background.—Primary lymphomas of the breast are rare, accounting for 1.7% to 2.2% of extranodal lymphomas and 0.38% to 0.7% of all non-Hodgkin lymphomas. Although secondary breast lymphomas are also rare, they represent the largest group of metastatic tumors of the breast. Objectives.—To investigate the clinicopathologic and immunophenotypic characteristics of breast lymphomas, the relative frequency of primary and secondary mammary lymphomas, and in selected cases, the role of gene rearrangement analysis in diagnosis and staging of these lymphomas. Results.—We conducted a retrospecti

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Carminato, Antonio, Marco Tecilla, Paola Roccabianca, et al. "CD30 Cross-Reactivity and Expression in Feline Normal Tissues and Lymphomas." Veterinary Pathology 57, no. 1 (2019): 49–55. http://dx.doi.org/10.1177/0300985819875745.

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CD30 is a transmembrane glycoprotein of the tumor necrosis factor receptor superfamily included in the diagnostic algorithm of human cutaneous, anaplastic large cell and Hodgkin lymphomas and represents an optimal therapeutic target for CD30+ tumors. Similar diagnostic and therapeutic approaches are largely missing for feline lymphomas. Cross-reactivity of the antihuman CD30 receptor clone Ber-H2 was investigated in feline lymphomas. Comparative analysis of feline and human CD30 identified 61% identity of the amino acid sequence, with 100% identity of the main sequence of the epitope targeted

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Сидорова, Ю. В., Н. В. Рыжикова, С. Ю. Смирнова та ін. "Определение B-клеточной клональности при лимфоме Ходжкина". Clinical Oncohematology 7, № 1 (2014): 63–66. https://doi.org/10.21320/2500-2139-2014-7-1-63-66.

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B-cell origin of Hodgkin’s lymphoma was demonstrated using microdissection and single cell PCR of Reed-Sternberg and Hodgkin cells (R. Kuppers et al., 1994). We assessed B-cell clonality in the biopsy samples of 35 patients with Hodgkin’s lymphoma without microdissection. B-cell clonality was evaluated using PCR amplification by IGH (FR1, FR2, FR3) and IGK (Vk-Jk, Vk/intron-Kde) gene rearrangements with multiplex BIOMED-2 primer sets and subsequent fragment analysis using ABI PRISM 3130 Genetic Analyzer (Applied Biosystems). Clonality was found in 11 out of 35 (31,5 %) formalin fixed paraffin-

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Lebedenco, Mihaela, Nicoleta Berbec, Oana Stanca, et al. "Immunohistochemistry in the therapeutic decision for Hodgkin’s lymphoma." Romanian Journal of Medical Practice 19, no. 1 (2024): 58–61. http://dx.doi.org/10.37897/rjmp.2024.1.12.

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Hodgkin's lymphoma is a highly curable malignant hemopathy in both adults and children with therapy adapted to risk factors, including both chemotherapy and radiotherapy. Through effective and curable therapeutic schemes there is a huge potential to improve the vital prognosis and the quality of life in the long term. 15-20% of patients in early stages (stages I, II) and 35-40% of those in advanced stages (III and IV) have relapses or resistance to first-line therapy. Molecular analysis of the cells facilitated the discovery that classical Hodgkin lymphoma, in the vast majority of cases, and p

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Buruiana, Sanda. "Incidence of antiphospholipid antibodies in new patients with non-Hodgkin lymphoma." Public Health, Economy and Management in Medicine, no. 4(91) (December 2021): 34–38. http://dx.doi.org/10.52556/2587-3873.2021.4(91).34-38.

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Non-Hodgkin’s lymphoma (NHL) presents a group of histologically and biologically inhomogeneous B and T cell neoplasms of lymphoid tissue with a completely unidentified etiology. Antiphospholipid antibodies (aPL) are antibodies produced as a result of misinterpretation of platelet membrane phospholipids. It is well known that antiphospholipid antibodies are general risk factors that induce the disorder of the physiological process of hemostasis. Respectively, it is interesting to appreciate the incidence of antiphospholipid antibodies in new non-Hodgkin lymphomas patients depending on age, sex,

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Vafaii, Pardis, and Haipeng Shao. "Stepwise development of classical Hodgkin lymphoma from diffuse large B-cell lymphoma." Advances in Modern Oncology Research 2, no. 5 (2016): 292. http://dx.doi.org/10.18282/amor.v2.i5.147.

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Classical Hodgkin lymphoma (cHL) and non-Hodgkin lymphoma rarely develop in the same patient synchronously or metachronously. Through a series of biopsies, we report a unique case of diffuse large B-cell lymphoma (DLBCL) with stepwise development of classical Hodgkin lymphoma. An intermediate stage of transformation was identified with scattered Reed-Sternberg/Hodgkin cells present in a background of the DLBCL cells. These Reed- Sternberg/Hodgkin cells showed typical immunophenotype of cHL cells and were associated with limited inflammatory cells. While Reed-Sternberg/Hodgkin-like cells are no

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Merryman, Reid W., Philippe Armand, Kyle T. Wright, and Scott J. Rodig. "Checkpoint blockade in Hodgkin and non-Hodgkin lymphoma." Blood Advances 1, no. 26 (2017): 2643–54. http://dx.doi.org/10.1182/bloodadvances.2017012534.

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AbstractClassical Hodgkin lymphoma (cHL) is characterized by nearly universal genetic alterations in 9p24.1, resulting in constitutive expression of PD-1 ligands. This likely underlies the unique sensitivity of cHL to PD-1 blockade, with response rates of ∼70% in relapsed/refractory disease. There are now numerous clinical trials testing PD-1 inhibitors in earlier stages of treatment and in combination with many other therapies. In general, non-Hodgkin lymphomas (NHLs) do not display a high frequency of 9p24.1 alterations and do not share cHL’s vulnerability to PD-1 blockade. However, a few en

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Jost, Philipp J., та Jürgen Ruland. "Aberrant NF-κB signaling in lymphoma: mechanisms, consequences, and therapeutic implications". Blood 109, № 7 (2006): 2700–2707. http://dx.doi.org/10.1182/blood-2006-07-025809.

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AbstractThe transcription factor NF-κB is a tightly regulated positive mediator of T- and B-cell development, proliferation, and survival. The controlled activity of NF-κB is required for the coordination of physiologic immune responses. However, constitutive NF-κB activation can promote continuous lymphocyte proliferation and survival and has recently been recognized as a critical pathogenetic factor in lymphoma. Various molecular events lead to deregulation of NF-κB signaling in Hodgkin disease and a variety of T- and B-cell non-Hodgkin lymphomas either upstream or downstream of the central

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Maman Brah, Moustapha, Amadou Djibrilla-Almoustapha, and Moustapha Elhadji-Chefou. "Epidemiological and histopathological aspects of lymphomas at Zinder National Hospital, Niger." European Journal of Theoretical and Applied Sciences 2, no. 1 (2024): 308–12. http://dx.doi.org/10.59324/ejtas.2024.2(1).26.

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Introduction: Lymphoma is a malignant lymphocytic hemopathy characterized by diffuse lymph node or extranodal infiltration. It occurs at all ages and poses a problem for us in terms of positive diagnosis and management. The objective of this study is to determine the epidemiological and histological aspects of lymphomas at the National Hospital Zinder. Methodology: This was a retrospective cross-sectional study of patient records collected for histopathological examination between November 2019 and December 2023. Included were patients of any age and of both sexes with their histopathological

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Moustapha, Maman Brah, Djibrilla-Almoustapha Amadou, and Elhadji-Chefou Moustapha. "Epidemiological and histopathological aspects of lymphomas at Zinder National Hospital, Niger." European Journal of Theoretical and Applied Sciences 2, no. 1 (2024): 308–12. https://doi.org/10.59324/ejtas.2024.2(1).26.

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Introduction: Lymphoma is a malignant lymphocytic hemopathy characterized by diffuse lymph node or extranodal infiltration. It occurs at all ages and poses a problem for us in terms of positive diagnosis and management. The objective of this study is to determine the epidemiological and histological aspects of lymphomas at the National Hospital Zinder. Methodology: This was a retrospective cross-sectional study of patient records collected for histopathological examination between November 2019 and December 2023. Included were patients of any age and of both sexes with their histopathological

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Eviana, Norahmawati, Oktaviana Hambalie Ailen, Prabawati Retnani Diah, Tri Endharti Agustina, and Rahmadiani Nayla. "Clinicopathological profile of Non-Hodgkin and Hodgkin Lymphoma at the Anatomical Pathology Laboratory of Saiful Anwar General Hospital Malang from January 2018 until May 2023." GSC Biological and Pharmaceutical Sciences 25, no. 1 (2023): 078–85. https://doi.org/10.5281/zenodo.10574644.

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Lymphomas are a lymphocyte-driven malignancy that comprise up to 10% of cancers diagnosed in individuals < 20 years of age globally. Malignant lymphomas are divided into Hodgkin Lymphoma (HL) and Non Hodgkin Lymphoma (NHL). In 2019 at United States, more than 82.000 new patients diagnosed with lymphoma. Since the epidemiology of Lymphoma is different across regions and may have change over time, its global distribution pattern, risk factors, and temporal trends need to be assessed for developing preventive measures. The purpose of this study was to determine the frequency of NHL and HL base

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Rzepakowska, Anna, Klaudyna Zwierzyńska, Ewa Osuch-Wójcikiewicz, and Kazimierz Niemczyk. "Lymphoid tissue neoplasms in the neck region – epidemiological and clinical analysis over 15 years." Otolaryngologia Polska 71, no. 3 (2017): 1–9. http://dx.doi.org/10.5604/01.3001.0010.0127.

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Aim: Epidemiological and clinical analysis of lymphoid tissue neoplasms in the neck region over a 15-year period. Material: There was performed retrospective analysis of 97 patients, aged 17 to 88 years, mean age of 60.3 years. The analysis included data from subjective study, physical examination, image and histopathological studies Results: Almost all cases were lymphoid neoplasms - 95 patients (98%). B cell lymphoma was the most commonly diagnosed lymphoma – 74 cases (76%), followed by Hodgkin's lymphoma- 19 cases (20%). Only two patients had T-cell lymphoma (2%). There was observed prevale

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Samiee, Fatemeh, Reza Mohammadi, Sadegh Shirian, et al. "Spectrum of lymphoma subtypes based on the latest World Health Organization classification in southern Iran from 2000 to 2011." Future Oncology 17, no. 34 (2021): 4733–44. http://dx.doi.org/10.2217/fon-2020-0534.

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Background: Lymphoma, both Hodgkin and non-Hodgkin, is one of the most common malignancies, with a distinct subtype distribution throughout the world. Methods: A total of 453 lymphoma cases, identified retrospectively from January 2000 to October 2011, were studied to identify the subtype distribution of lymphoma in our center, located in southern Iran, according to the latest WHO classification. Results: The most common sites of involvement of all lymphomas were extranodal (59.16%). The highest frequency of extranodal sites in all lymphoid neoplasms were associated with diffuse large B-cell l

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Habeeb, Rana, Lina Al hafar, and Fawza Monem. "EBV Plasma Epstein-Barr Virus (EBV) DNA as a Biomarker for Diagnosis of EBV-positive Hodgkin Lymphoma in Syria." Journal of Infection in Developing Countries 15, no. 12 (2021): 1917–22. http://dx.doi.org/10.3855/jidc.14919.

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Introduction: Epstein Barr Virus - positive Hodgkin lymphoma is defined by the presence of Epstein-Barr virus (EBV) in tumor cells. EBV plays an important role in the development and prognosis of Hodgkin's lymphoma. The standard way to detect EBV in Hodgkin lymphoma is immunohistochemistry stains for latent membrane protein-1 (LMP1) in tumor cells. The present study aimed to evaluate plasma Epstein-Barr virus (EBV) DNA as a noninvasive biomarker for diagnosis of EBV-positive Hodgkin lymphoma. Methodology: The study included 60 newly diagnosed patients with Hodgkin lymphoma, ranging in ag

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Mohanty, Pranita, and Sonali Kar. "Primary Hodgkin’s lymphoma of stomach: A case report with literature review." Journal of Cancer Research and Therapeutics 21, no. 1 (2025): 295–98. https://doi.org/10.4103/jcrt.jcrt_1948_23.

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ABSTRACT The gastrointestinal (GI) tract is the commonest site of extranodal lymphoma, and the stomach is the most frequent site for extranodal GI lymphoma (60%). Primary gastric lymphoma (PGL) is relatively rare, but the incidence of the disease is increasing. About 90% of primary gastric lymphoma is non-Hodgkin type (NHL), either mucosal-associated lymphoid tissue lymphoma or diffuse large B-cell lymphoma. In contrast, primary Hodgkin’s lymphoma (HL) is very rare. Until now, a handful of cases have been reported in the literature. It poses a great challenge in diagnosis due to its rarity and

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Aschie, Mariana, Andreea Georgiana Stoica, Anca Florentina Mitroi, Georgeta Camelia Cozaru, Gabriela Stanciu, and Anca Chisoi. "Synchronous Association of Two Types of Indolent Lymphomas." Revista de Chimie 69, no. 12 (2019): 3653–55. http://dx.doi.org/10.37358/rc.18.12.6812.

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Small lymphocytic lymphomas (SLL) and lymphoplasmacytic lymphomas (LPL) are part of indolent non-Hodgkin�s lymphoma . LPL of the skin is very rare and synchronous association of two types of indolent lymphomas is extremely rare.We report the case of 75 years old male patient diagnosed with two types of indolent non-Hodgkin�s lymphoma, lymphoplasmacytic lymphomas of the skin associated with nodal small lymphocytic lymphomas. We present this unique case with a review of the literature of synchronous non-Hodgkin lymphomas highlighting the clinical, pathological and genetic methods involved in the

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Bairey, Osnat, Idit Pazgal, Elimelech Okon, Matityahu Shaklai, and Sarah Morgenshtern. "Lack of HER-2/neu Expression in Hodgkin and Non-Hodgkin Lymphoma." Archives of Pathology & Laboratory Medicine 126, no. 5 (2002): 574–76. http://dx.doi.org/10.5858/2002-126-0574-lohnei.

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Abstract Objective.—Overexpression of HER-2/neu oncoprotein, a tyrosine kinase receptor, occurs in a variety of human cancers and has been shown to play a critical role in their development. This overexpression is usually associated with poor clinical outcome. The significance of HER-2/neu in lymphomas is unknown. The aim of this study was to evaluate the expression of HER-2/neu in the malignant lymphomas: non-Hodgkin and Hodgkin lymphomas. Methods.—We studied formalin-fixed, paraffin-embedded tissue from 50 patients with lymphoma. Forty-two specimens were from patients with various types of n

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Anandani, Garima M., Prabhu Manivannan, Sree Rekha J, Rakhee Kar, and Debdatta Basu. "Patterns of bone marrow infiltration in lymphomas- A retrospective descriptive analysis from a tertiary care centre in Southern India." IP Journal of Diagnostic Pathology and Oncology 7, no. 4 (2023): 223–28. http://dx.doi.org/10.18231/j.jdpo.2022.053.

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Bone marrow biopsy (BMB) examination is the gold standard for staging of lymphoma which is interpreted along with other clinical, laboratory and radiological investigations. This study aimed to evaluate the various patterns of BMB infiltration by lymphomas which include Hodgkin and Non Hodgkin lymphoma and the usefulness of BMB compared to bone marrow aspiration (BMA). : In a period of three years, there were 212 cases which showed lymphoma infiltration in bone marrow. We assessed the peripheral blood smear (PBS), BMA and BMB slides and concordance between each was evaluated. BMB slides were a

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Maataoui-Belabbes, Hajar, Hanaa Bencharef, Bouchra Oukkache, Abdellah Madani, and Mouna Lamchahab. "Macrophage activation syndrome revealing Hodgkin lymphoma." Annales Africaines de Medecine 17, no. 3 (2024): e5728-e5733. http://dx.doi.org/10.4314/aamed.v17i3.15.

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Macrophage activation syndrome is an anatomo-clinical entity due to inappropriate stimulation of macrophages. It can be of primary or secondary origin. Blood diseases responsible for reactive macrophage activation syndrome are mainly T or NK lymphomas. The association with Hodgkin lymphoma is exceptional. We report a case of a young adult whose macrophage activation syndrome revealed Hodgkin lymphoma. The diagnosis of macrophage activation syndrome was assured in the light of compatible clinical, biological, and cytological signs. The etiological diagnosis was guided by the bone marrow biopsy

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Lin, Yuan, Gilberto D. Rodrigues, John F. Turner, and Mohammad A. Vasef. "Plasmablastic Lymphoma of the Lung." Archives of Pathology & Laboratory Medicine 125, no. 2 (2001): 282–85. http://dx.doi.org/10.5858/2001-125-0282-plotl.

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Abstract Non-Hodgkin lymphomas associated with acquired immunodeficiency syndrome are heterogeneous. Recently, a novel subtype of non-Hodgkin lymphoma occurring mostly in patients with acquired immunodeficiency syndrome has been described and designated as plasmablastic lymphoma. The histomorphologic and immunophenotypic findings of this distinct subtype of non-Hodgkin lymphoma have been characterized previously. Most patients present with oral cavity involvement. We report a case of plasmablastic lymphoma presenting as a lung tumor. To our knowledge, this is the first case report of this unus

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Herraiz, J. L., A. Llueca, Y. Maazouzi, D. Piquer, A. Palmeiro, and E. Calpe. "Primary T-Cell Non-Hodgkin Lymphoma of the Vagina." Case Reports in Obstetrics and Gynecology 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/893083.

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The primary vaginal T-cell non-Hodgkin lymphoma is a rare form of lymphoma. Most of the previously published cases were about B-cell non-Hodgkin lymphomas. We present the case of a vaginal mass in an 82-year-old patient presenting vaginal bleeding. The results of the immunohistological studies of the mass revealed the presence of a cytotoxic T-cell non-Hodgkin lymphoma, which is the least common subtype.

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