Academic literature on the topic 'Holland-American line'

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Journal articles on the topic "Holland-American line"

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Ma, Hayley, Sophia Romero, Anna de Regt, et al. "Abstract 2933: IDP-001 is a potent bispecific ADC with in vivo activity against mouse xenograft tumor models expressing EGFR and CDCP1." Cancer Research 85, no. 8_Supplement_1 (2025): 2933. https://doi.org/10.1158/1538-7445.am2025-2933.

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Abstract EGFR is a clinically-validated target that is overexpressed and activated in many human cancers and associated with poor prognosis. However, ADCs targeting EGFR exhibit toxicity due to expression on healthy tissue (1), and EGFR can show heterogeneous tumor expression (2). We utilized InduPro’s proprietary MIntTM platform to identify proteins inherently proximal to EGFR on tumor cells. CUB domain-containing protein 1 (CDCP1) was identified as a TAPA (tumor associated proximity antigen) of interest. Like EGFR, CDCP1 is over-expressed in multiple cancers and plays key roles in oncogenic
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Olson, Joel. "Political Theory and the Racial OrderThe Evidence of Things Not Said: James Baldwin and the Promise of American Democracy. By Lawrie Balfour Black Visions: The Roots of Contemporary African-American Political Ideologies. By Michael C. Dawson Against Race: Imagining Political Culture beyond the Color Line. By Paul Gilroy The Body Politic: Foundings, Citizenship, and Difference in the American Political Imagination. By Catherine A. Holland." Polity 36, no. 3 (2004): 529–41. http://dx.doi.org/10.1086/polv36n3ms3235389.

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Kuo, Meredith, Jason Chen, Sacha Holland, et al. "Abstract 1816: Identification of novel VPS4A inhibitors for the treatment of VPS4B-deleted cancers." Cancer Research 82, no. 12_Supplement (2022): 1816. http://dx.doi.org/10.1158/1538-7445.am2022-1816.

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Abstract Synthetic lethality occurs when a single gene alteration is compatible with cell viability, but an additional co-occurring genetic alteration leads to cell death. In the context of cancer therapy, synthetic lethality can occur through the inhibition of a target that is selectively essential to tumors harboring a specific genetic alteration. Gene paralog pairs represent one promising class of synthetic lethal cancer targets, wherein the function of one paralog is lost in tumor cells, rendering them dependent on the remaining paralog to carry out an essential cellular process. To identi
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Angelov, Daniel, Darragh Nimmo, Gráinne Holland, et al. "Abstract 3805: Loss of NSD2 induces acquired resistance to EZH2 inhibitors in B-cell lymphoma by disrupting enhancer function." Cancer Research 85, no. 8_Supplement_1 (2025): 3805. https://doi.org/10.1158/1538-7445.am2025-3805.

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Abstract Introduction: Epigenetic enzymes that add or remove histone post-translational modifications are essential for cellular identity and frequently mutated in cancer. For example, in B-cell lymphomas, change-of-function mutations in EZH2, the catalytic subunit of Polycomb Repressive Complex 2 (PRC2), result in increased H3K27me3 levels and transcriptional silencing of key genes required for B-cell differentiation. However, the efficacy of EZH2 inhibitors in clinical trials has been limited by acquired resistance. Understanding the mechanisms of resistance to EZH2 inhibitors is crucial for
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Schilder, A. M. C., S. M. Smokevitch, M. Catal, and W. K. Mann. "First Report of Anthracnose Caused by Elsinoë ampelina on Grapes in Michigan." Plant Disease 89, no. 9 (2005): 1011. http://dx.doi.org/10.1094/pd-89-1011a.

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In 2001, dark brown-to-purple, sunken lesions were observed on shoots and berries of 5-year-old ‘Mars’ and ‘Marquis’ table grapes (Vitis spp.) in Onondaga, MI. The disease affected >90% of the vines. Many leaves were curled and distorted and some shoot tips had died back. Older wood showed crater-like indentations. No fruit was harvested due to poor fruit quality. Lesions (at least 10 per sample) were surface-disinfested with 1% sodium hypochlorite, placed on potato dextrose agar (PDA), and kept at 23 to 25°C under ambient light. Sphaceloma ampelinum de Bary (teleomorph Elsinoë ampelina She
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MURILLO, MAURICIO, and JIMMIE C. HOLLAND. "Clinical practice guidelines for the management of psychosocial distress at the end of life." Palliative and Supportive Care 2, no. 1 (2004): 65–77. http://dx.doi.org/10.1017/s1478951504040088.

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After years of neglect, care at the end of life is receiving increasing attention and concern. It is then that the body is consumed by a progressive and mortal illness, and the person must cope not only with the bodily symptoms, but also with the existential crisis of the end of life and approaching death. As the body suffers, the mind is indeed “commanded … to suffer with the body,” as Shakespeare so well described. Thus, suffering near the end of life encompasses both the mind and the body. Providing optimal symptom relief and alleviation of suffering is the highest priority. However, eviden
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Sullivan, Ryan, Laura Collins, Manuel Rodrigues, et al. "Abstract 1035: Early ctDNA reduction is associated with better overall survival in the Ph 3 trial of tebentafusp in previously untreated metastatic uveal melanoma." Cancer Research 83, no. 7_Supplement (2023): 1035. http://dx.doi.org/10.1158/1538-7445.am2023-1035.

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Abstract Background: Tebentafusp (tebe), a bispecific ImmTAC (gp100 × CD3) showed significant overall survival (OS) benefit (HR 0.51) versus investigator’s choice in a Phase (Ph) 3 trial in first line (1L) HLA-A*02:01 pts with metastatic uveal melanoma (mUM) [Nathan NEJM 2021]. In a Ph2 trial of tebe in previously treated mUM, OS was improved regardless of RECIST best response and the degree of early reduction in ctDNA was a better predictor of OS [Carvajal Nat Med 2022]. Here we sought to replicate these results in the Ph3 trial of tebe in 1L mUM pts. Methods: 1L HLA-A*02:01 pts with mUM rece
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Sacco, Joseph J., Richard D. Carvajal, Marcus O. Butler, et al. "Abstract CT223: Long-term survival follow-up of tebentafusp in previously treated metastatic uveal melanoma (mUM)." Cancer Research 83, no. 8_Supplement (2023): CT223. http://dx.doi.org/10.1158/1538-7445.am2023-ct223.

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Abstract Background: Tebentafusp, a bispecific (gp100 x CD3) ImmTAC, is approved for adult HLA-A*02:01+ patients with unresectable or metastatic uveal melanoma (mUM). In the Ph2 IMCgp100-102 study of pts with previously treated mUM (NCT02570308), tebentafusp demonstrated a median OS of 16.8 months and 1-year OS of 61% after a minimum 2 yrs of follow-up, nearly double the historical observed rates.12, Here we present the final analysis of OS of the Ph2 IMCgp100-102 study. Methods: 127 HLA-A*02:01+ 2L+ pts with mUM were dosed weekly with intravenous tebentafusp following intra-patient dose escal
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Elster, Peter. "“Church, Family, Hard Work, and Dutch Clean”." Religie & Samenleving 4, no. 2 (2009): 109–38. http://dx.doi.org/10.54195/rs.13122.

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This article pictures the youth memories of older Dutch-Americans who grew up in the “Dutch enclave” of Holland, Michigan (USA). This area is heavily populated by Dutch immigrants sharing traditional Calvinist religious values, norms, and beliefs. Findings are based on oral interviews among a sample of older respondents from the area (mean age is 81 yrs.). The study combines a generational approach with an oral history methodology. Results indicate that respondents cherish their formative years, their Calvinist Dutch-American upbringing, and feel that their socialization in strict values, norm
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Khruleva, Irina Yur'evna. "The Theological Polemics of Jonathan Edwards and George Whitefield: Differences in Their Understanding of the "Great Awakening" of the 1740s in New England." Исторический журнал: научные исследования, no. 1 (January 2020): 162–71. http://dx.doi.org/10.7256/2454-0609.2020.1.30503.

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The first "Great Awakening" took hold of all British colonies in North America in the 1730s-1750s and developed contemporaneously with the Enlightenment movement, which had a significant impact on all aspects of life in the colonies, influencing religion, politics and ideology. The inhabitants of the colonies, professing different religious views, for the first time experienced a general spiritual upsurge. The colonies had never seen anything like the Great Awakening in scale and degree of influence on society. This was the first movement in American history that was truly intercolonial in nat
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Books on the topic "Holland-American line"

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A taste of excellence cookbook: Holland America Line. Rizzoli, 2006.

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Greene, Dana. In Search of Voice. University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252037108.003.0003.

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This chapter details events in Denise Levertov's life after she set sail for Holland in January 1947, to work as an au pair. Levertov was barely twenty-three when she left England presumably for adventure, but in doing so she also escaped. She had no suspicion that by the year's end her life would change irrevocably. Her hastily arranged job as an au pair was seemingly a means to an end—the opportunity to travel. But the adventure began inauspiciously. Holland was cold, damp, and ravaged by war. She did not like the food or the Dutch, whom she considered tactless and dull. She left Holland for
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Feys, Torsten. The Battle for the Migrants. Liverpool University Press, 2012. http://dx.doi.org/10.5949/liverpool/9781927869000.001.0001.

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This book approaches the well-documented study of European mass migration to the United States of America from the viewpoint of mass migration as a business venture. The overall purpose is to demonstrate that maritime and migration histories are interlinked and dependent on a deeper understanding of the social, economic, and political factors at work in the nineteenth century Atlantic community. It centres on both the evolution of the port of Rotterdam as a migration gateway, and the crucial role of the Holland-America line as a regulator of the North American passenger trade. The first part o
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Fraser, Benjamin. Beyond Sketches of Spain. Oxford University Press, 2022. http://dx.doi.org/10.1093/oso/9780197549285.001.0001.

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Abstract No musician did more to shape Iberian jazz than pianist Vicenç Montoliu i Massana (1933–1997), who was known simply as “Tete.” Reflecting his fascination with the modernist aesthetics of mid-century jazz, Tete Montoliu was known for his quick fingering, his carefully crafted mix of lyricism and dissonance, his penchant for discordant crashes, and his development of highly original compositions. He boasted some 100 recordings spanning Denmark, Germany, Holland, Spain, and the United States, and performed with the most notable jazz luminaries, including Lionel Hampton, Rahsaan Roland Ki
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Cipriano Venzon, Ann. From Whaleboats to Amphibious Warfare. Praeger, 2003. http://dx.doi.org/10.5040/9798400654985.

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An examination of Holland Smith's career in the Marine Corps follows its evolution from an insular constabulary at the turn of the 20th century to a juggernaut, landing American troops island by island in vital amphibious engagements up to 1945. Serving in important assignments from the Philippines to China to Latin America, Smith became deeply involved in the development of amphibious strategy and tactics, as well as in the creation of proper landing craft by the early 1930s. After Pearl Harbor, the Marines would turn to him to plan and lead operations in the Gilberts, the Marianas, and the V
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Book chapters on the topic "Holland-American line"

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Stephen Lansing, J. "Anti-Chaos, Common Property, and the Emergence of Cooperation." In Dynamics in Human and Primate Societies. Oxford University Press, 2000. http://dx.doi.org/10.1093/oso/9780195131673.003.0014.

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Complex adaptive systems, as conceived by John Holland, are groups of agents engaged in a process of coadaptation, in which adaptive moves by individuals have consequences for the group. Holland and others have shown that under certain circumstances simple models of this process show surprising abilities to self-organize (Holland 1993; Kauffman 1993). Complex adaptive systems have interesting mathematical properties, and the process of "anti-chaos"-—the spontaneous crystallization of ordered patterns in initially disordered networks— has become a new area of interdisciplinary research. But the
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Weltak, Marcel. "Surinamese Jazz in the Netherlands." In Surinamese Music in the Netherlands and Suriname. University Press of Mississippi, 2021. http://dx.doi.org/10.14325/mississippi/9781496816948.003.0007.

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Surinamese jazz musicians began playing jazz in The Netherlands earlier than they did in Suriname, and jazz has different backgrounds in both countries as well. This chapter deals with the rise and reception of Surinamese jazz musicians in The Netherlands from the 1930s through to the 1970s. “It cannot be a coincidence,” wrote Herman ‘Doctor Jazz’ Openneer, “that Surinamese jazz began in The Netherlands in 1935.” The fee people like Armstrong commanded for a performance was much too high for many promotors in those days. Someone soon came up with the idea of offering Surinamers contracts and g
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Scliar-Cabral, Leonor. "Difficulties for Translating Quevedo’s Sonnets from Portuguese Translations into English." In Computational Semantics [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.109699.

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The aim of this chapter is a discussion about the criteria used on the translation of Brazilian Portuguese poetry into American English. I thus exemplify it with the translations of Quevedo’s sonnets, namely the sonnet “Desde a torre,” “From the tower.” As one goes through Quevedo’s sonnets, one can notice the recurrence of the semantic fields “fire” and “prison.” The first appears until fatigue in the opposites game within the Petrarquean pairs tradition like fire/snow~water. In order to enjoy the multiple readings that Quevedo offers, it is necessary to delve into the disappointments of whic
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Gillies, Malcolm, and David Pear. "1922–1939 ‘An Untamed Buffalo’." In The All-Round Man. Oxford University PressOxford, 1994. http://dx.doi.org/10.1093/oso/9780198163770.003.0003.

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Abstract In August 1922 Grainger returned to Europe, for the first time since 1914, in an attempt to regain something of places and times once shared with his mother. He resuscitated the plans of 1914 to collect Danish folk music in Jutland and gave concerts in Scandinavia and Holland. American Hotel, Amsterdam, Oct 21, 1922 Cyril dear, In a day or two I will be sending you the photo of my beloved mother that I like best & (if I can find a copy) one of her & me together playing the English Dance that is dedicated to you, last sum mer. You say you have a small postcard of us both. Will
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Rubin, Julius H. "Evangelical Pietism in America." In Religious Melancholy and Protestant Experience in America. Oxford University PressNew York, NY, 1994. http://dx.doi.org/10.1093/oso/9780195083019.003.0002.

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Abstract English Puritans suffered religious intolerance in the 1620s at the hands of William Laud and King Charles I. Laud delivered a sermon to Parliament in 1626 impugning Puritanism as an affront to church and state. He redoubled the persecution of nonconformist groups after his appointment as Archbishop of Canterbury in 1633. Many fled England, and after a brief sojourn in Holland, migrated to America, founding Massachusetts Bay and other New England settlements. As God’s faithful on a divinely appointed mission—an “errand into the wilderness”1—they came to American shores freed from Old
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Dallek, Robert. "Prologue: An American Internationalist." In Franklin D. Roosevelt and American Foreign Policy, 1932-1945. Oxford University PressNew York, NY, 1995. http://dx.doi.org/10.1093/oso/9780195097320.003.0001.

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Abstract ASIDE FROM HIS COUSIN Theodore, Franklin D. Roosevelt was the most cosmopolitan American to enter the White House since John Quincy Adams in 1825. The son of James and Sara Delano Roosevelt, Hudson River Valley aristocrats who habitually lived and traveled abroad, Franklin was introduced to Europe in 1885 at the age of three. His first memories, in fact, were of a lost jumping jack swept away by seawater that entered the family cabin on a return voyage from England in April of that year. Between the ages of seven and fifteen he spent a few months annually in Britain, France, and Germa
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Mesquita, Batja. "Emotions as Dynamic Cultural Phenomena." In Handbook of Affective Sciences. Oxford University PressNew York, NY, 2002. http://dx.doi.org/10.1093/oso/9780195126013.003.0046.

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Abstract Following Darwin’s work on emotional expression, many psychologists set out to demonstrate the features of emotions that are universal. Cross-cultural research has suggested universality of a number of facial, vocal, and bodily expressions, antecedent events, appraisals, action readiness modes, and physiological changes associated with certain emotions (for reviews of this evidence, see Mesquita & Frijda, 1992; Mesquita, Frijda, & Scherer, 1997). The evidence for universal constituents of emotions is convincing. But does this evidence mean that the emotional experience of peop
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