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Journal articles on the topic 'Home cage'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Neff, Ellen P. "Home sweet home cage." Lab Animal 47, no. 10 (2018): 261–64. http://dx.doi.org/10.1038/s41684-018-0151-3.

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Rekilä, Teppo, Leena Ahola, Jaakko Mononen, and Mikko Harri. "Effect of the environment inside and outside the cage on the activity and behaviour test performance of silver foxes." Agricultural and Food Science 7, no. 1 (1998): 13–19. http://dx.doi.org/10.23986/afsci.72851.

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On the basis of daily activity in the home cage and the open field test the effect of the internal design and location of cages on the behaviour of silver foxes (Vulpes vulpes) during a growth period was evaluated. The inclusion of platforms in cages increased the daytime activity of silver foxes in their home cage, but the inclusion of nest boxes did not. Silver foxes housed at the front of the animal barn were less active during the working day and more active in the evening than were animals housed at the rear. The results of the open field test did not differ significantly between animals

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3

Sherwin, CM, and IAS Olsson. "Housing conditions affect self-administration of anxiolytic by laboratory mice." Animal Welfare 13, no. 1 (2004): 33–38. http://dx.doi.org/10.1017/s0962728600026634.

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AbstractTests of emotionality conducted outside the home-cage show that rodents from standard laboratory housing are more anxious than animals from enriched housing; however, it is not known if this also indicates increased anxiety within the home-cage. We used a novel method, recording the self-administration of a psychoactive anxiolytic, to examine home-cage anxiety levels of laboratory mice (three per cage) in Standard (n = 10 cages), Unpredictable (n = 10 cages) and Enriched (n = 6 cages) housing. The mice were given a choice of drinking either non-drugged water or a solution of the benzod

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Harris, AP, RB D’Eath, and SD Healy. "A cage without a view increases stress and impairs cognitive performance in rats." Animal Welfare 19, no. 3 (2010): 235–41. http://dx.doi.org/10.1017/s0962728600001615.

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AbstractSingle housing is believed to be chronically stressful and to have a negative impact on welfare and cognition in rats (Rattus norvegicus). However, single housing does not consistently evoke stress-like responses nor does it consistently impair cognitive performance. In an experiment in which all cages were separated by an opaque barrier, single- and pair-housed pigmented (dark-eyed) rats performed equally in a cognitive test and displayed similar levels of anxiety during testing. Additionally, bar biting in the home cage did not differ between the two groups. Stress levels both during

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Barabas, Amanda J., Helena A. Soini, Milos V. Novotny, et al. "Assessing the effect of compounds from plantar foot sweat, nesting material, and urine on social behavior in male mice, Mus musculus." PLOS ONE 17, no. 11 (2022): e0276844. http://dx.doi.org/10.1371/journal.pone.0276844.

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Home cage aggression causes poor welfare in male laboratory mice and reduces data quality. One of the few proven strategies to reduce aggression involves preserving used nesting material at cage change. Volatile organic compounds from the nesting material and several body fluids not only correlate with less home cage aggression, but with more affiliative allo-grooming behavior. To date, these compounds have not been tested for a direct influence on male mouse social behavior. This study aimed to determine if 4 previously identified volatile compounds impact home cage interactions. A factorial

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Dutton, Gail. "Home Cage AI-Monitoring." Genetic Engineering & Biotechnology News 45, no. 1 (2025): 44–45. https://doi.org/10.1089/gen.45.01.14.

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7

Townsend, P. "USE of In-Cage Shelters by Laboratory Rats." Animal Welfare 6, no. 2 (1997): 95–103. http://dx.doi.org/10.1017/s0962728600019564.

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AbstractThe effect of providing a shelter to single-housed rats was measured in terms of the preference shown for a cage containing a shelter compared with a barren cage, the range of behaviours performed and the apparent fearfulness of the animals. All animals showed a strong preference for cages containing a shelter and rats housed in this environment showed increased exploratory behaviour and were apparently less fearful, based on their willingness to leave the home-cage. It would seem appropriate to provide enclosed shelters within the cages of laboratory rats as a way of improving their e

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Mashudi, Mashudi, and Misbahul Ali. "PENGARUH INDUSTRI RUMAHAN KERAJINAN SANGKAR BURUNG TERHADAP PEREKONOMIAN MASYARAKAT SANGGRAAGUNG SOCAH BANGKALAN." Iltizam : Jurnal Ekonomi dan Keuangan Islam 2, no. 1 (2024): 60–74. http://dx.doi.org/10.35316/iltizam.v2i1.5420.

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This study was motivated by the researcher's curiosity about the influence of the home industry of bird cage crafts on improving society's economy in the village of Sanggra Agung, which has been doing these crafts for generations. Although they continuously produce bird cages, it seems that the economy of the bird cage craftsmen is still not growing. The study was carried out using a quantitative non-sampling method because the number of craftsmen was still below 100, and the data were obtained from the responses to the craftsmen's questionnaire and observations in the field about the home ind

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Lewis, RS, and JL Hurst. "The assessment of bar chewing as an escape behaviour in laboratory mice." Animal Welfare 13, no. 1 (2004): 19–25. http://dx.doi.org/10.1017/s0962728600026610.

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AbstractThe ability to measure objectively how an animal perceives its home environment is essential for improving the housing and husbandry conditions of laboratory animals. Chewing at cage bars by a rodent may reflect the animal's desire to escape from its home cage and thus provide a measure of the relative aversiveness or inadequacy of different housing conditions from the animal's viewpoint. To assess whether bar chewing by laboratory mice is an escape behaviour, adult male and female ICR-(CD-1) mice were housed individually or in same-sex groups of three in modified shoebox-type cages. C

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10

Barabas, Amanda J., Helena A. Soini, Milos V. Novotny, et al. "Compounds from plantar foot sweat, nesting material, and urine show strain patterns associated with agonistic and affiliative behaviors in group housed male mice, Mus musculus." PLOS ONE 16, no. 5 (2021): e0251416. http://dx.doi.org/10.1371/journal.pone.0251416.

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Excessive home cage aggression often results in severe injury and subsequent premature euthanasia of male laboratory mice. Aggression can be reduced by transferring used nesting material during cage cleaning, which is thought to contain aggression appeasing odors from the plantar sweat glands. However, neither the composition of plantar sweat nor the deposits on used nesting material have been evaluated. The aims of this study were to (1) identify and quantify volatile compounds deposited in the nest site and (2) determine if nest and sweat compounds correlate with social behavior. Home cage a

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Streiff, Christina, Adrian Herrera, Bernhard Voelkl, Rupert Palme, Hanno Würbel, and Janja Novak. "The impact of cage dividers on mouse aggression, dominance and hormone levels." PLOS ONE 19, no. 2 (2024): e0297358. http://dx.doi.org/10.1371/journal.pone.0297358.

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Home cage aggression in group-housed male mice is a major welfare concern and may compromise animal research. Conventional cages prevent flight or retreat from sight, increasing the risk that agonistic encounters will result in injury. Moreover, depending on social rank, mice vary in their phenotype, and these effects seem highly variable and dependent on the social context. Interventions that reduce aggression, therefore, may reduce not only injuries and stress, but also variability between cage mates. Here we housed male mice (Balb/c and SWISS, group sizes of three and five) with or without

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Misto, Tri Mulyono, Imam Rofi’i, Arry Yuariatun Nurhayati, Yuda Cahyoargo Hariadi, and Linggar Ayu Octaviani. "Measuring The Amount Of Ammonia Gas In Cattle Using The MQ137 Sensor In Rawan Village, Mayang District, And Member District With The Goal Of Raising Public Health Standards." Jurnal Inovasi Sains dan Teknologi untuk Masyarakat 2, no. 1 (2024): 22–30. http://dx.doi.org/10.19184/instem.v2i1.757.

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The majority of the farmers in Pringtali Hamlet, Mayang Village, Jember Regency, are also cattle breeders. Cattle breeders make up the majority of farmers. They construct basic cow enclosures; the majority are joined to the home, while others are independent. For the two of them, the cage's quality does not match the standards for cleanliness. Even in cages attached to the home, the smell of cow poo can be detected up to three meters outside the cage and within the main house. Ammonia is often the gas that is released from either liquid or solid cow manure. This gas can have some negative effe

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13

Sanguinetti-Scheck, Juan Ignacio, and Michael Brecht. "Home, head direction stability, and grid cell distortion." Journal of Neurophysiology 123, no. 4 (2020): 1392–406. http://dx.doi.org/10.1152/jn.00518.2019.

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The home is a unique location in the life of humans and animals. In rats, home presents itself as a multicompartmental space that involves integrating navigation through subspaces. Here we embedded the laboratory rat’s home cage in the arena, while recording neurons in the animal’s parasubiculum and medial entorhinal cortex, two brain areas encoding the animal’s location and head direction. We found that head direction signals were unaffected by home cage presence or translocation. Head direction cells remain globally stable and have similar properties inside and outside the embedded home. We

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Avimova, Kseniya P., and Dmitry B. Sandakov. "The influence of the stereotypic forms of activity in mice behaviour in standard behavioural tests." Journal of the Belarusian State University. Biology, no. 3 (October 22, 2021): 47–58. http://dx.doi.org/10.33581/2521-1722-2021-3-47-58.

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Laboratory animals often develop abnormal repetitive (stereotypic) behaviour that can influence both physiology and behavioural test results. Such abnormal behaviours usually develop in suboptimal environment and increase over time. To explore the development of stereotypic forms of activity night home-cage behaviour of laboratory mice was analysed and collated with the behaviour in open field (OFT), hole-board (HBT) and tail suspension (TST) tests twice within 16 weeks. Mice expressed few stereotypies and their duration lessened over time from median 8.2 to 1.0 %. In contrast, grooming behavi

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15

Hasriadi, Peththa Wadu Dasuni Wasana, Opa Vajragupta, Pornchai Rojsitthisak, and Pasarapa Towiwat. "Automated home-cage monitoring as a potential measure of sickness behaviors and pain-like behaviors in LPS-treated mice." PLOS ONE 16, no. 8 (2021): e0256706. http://dx.doi.org/10.1371/journal.pone.0256706.

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The use of endotoxin, such as lipopolysaccharide (LPS) as a model of sickness behavior, has attracted recent attention. To objectively investigate sickness behavior along with its pain-like behaviors in LPS-treated mice, the behavioral measurement requires accurate methods, which reflects clinical relevance. While reflexive pain response tests have been used for decades for pain assessment, its accuracy and clinical relevance remain problematic. Hence, we used automated home-cage monitoring LABORAS to evaluate spontaneous locomotive behaviors in LPS-induced mice. LPS-treated mice displayed sic

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Ahloy-Dallaire, Jamie, Jon D. Klein, Jerry K. Davis, and Joseph P. Garner. "Automated monitoring of mouse feeding and body weight for continuous health assessment." Laboratory Animals 53, no. 4 (2018): 342–51. http://dx.doi.org/10.1177/0023677218797974.

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Routine health assessment of laboratory rodents can be improved using automated home cage monitoring. Continuous, non-stressful, objective assessment of rodents unaware that they are being watched, including during their active dark period, reveals behavioural and physiological changes otherwise invisible to human caretakers. We developed an automated feeder that tracks feed intake, body weight, and physical appearance of individual radio frequency identification-tagged mice in social home cages. Here, we experimentally induce illness via lipopolysaccharide challenge and show that this automat

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17

Varholick, Justin A., Gizelle Godinez, Ashley Jenkins, Sarim Mobin, and Malcolm Maden. "Bite Wounds and Dominance Structures in Male and Female African Spiny Mice (Acomys cahirinus): Implications for Animal Welfare and the Generalizability of Experimental Results." Animals 14, no. 1 (2023): 64. http://dx.doi.org/10.3390/ani14010064.

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Bite wounds due to aggression in male laboratory mice (Mus musculus) are a major welfare concern, often leading to attrition, chronic activation of the innate immune system, and significant impacts on the experimental results derived from the use of these animals as models. Bite wounding within the home-cage of spiny mice (Acomys cahirinus)—a valuable research model for wound healing and menstruation—is poorly characterized. While we have anecdotally observed frequent bite wounding in Acomys, the frequency of aggression within the home-cage, the severity of the bite wounds, and the types of do

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18

Try, Pieter, René H. Tolba, and Marion Gebhard. "Vibration-Based Non-Contact Activity Classification for Home Cage Monitoring Using a Tuned-Beam IMU Sensing Device." Sensors 25, no. 8 (2025): 2549. https://doi.org/10.3390/s25082549.

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This work presents a vibration-based non-contact monitoring method to classify the physical activity of a mouse inside a home cage. A novel tuned-beam sensing device is developed to measure low-amplitude activity-induced cage vibrations. The sensing device uses a mechanical beam structure to enhance a six-axis IMU that increases the signal-to-noise ratio (SNR) by 20 to 40 times in a relevant environment. A sophisticated classification algorithm is developed to process vibration sequences with a variable time frame that utilizes multi-level discrete wavelet transformation (MLDWT) to extract tim

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19

Mueller, Marissa, Selma Tir, Carina Pothecary, et al. "The SnackerTracker: A novel home-cage monitoring device for measuring food-intake and food-seeking behaviour in mice." Wellcome Open Research 10 (April 4, 2025): 172. https://doi.org/10.12688/wellcomeopenres.23850.1.

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Background Accurately measuring activity and feeding is important in laboratory animal research, whether for welfare-monitoring or experimental recording. Quantification commonly involves manual pellet-weighing; however, this can physically disturb animals and cannot continuously assess both the amount and pattern of feeding over time. Improved means of food-intake measurement have been developed but can be costly and incompatible with many cage configurations. Methods We developed the SnackerTracker—a novel home-cage monitoring system which continuously records food-intake, food-seeking activ

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20

Le Bras, Alexandra. "Light and activity in the home cage." Lab Animal 51, no. 3 (2022): 76. http://dx.doi.org/10.1038/s41684-022-00935-y.

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21

Yan, Rongzhen, and Qiang Zhou. "Coding of “Home Cage” by PFC Neurons." Neuroscience 393 (November 2018): 33–41. http://dx.doi.org/10.1016/j.neuroscience.2018.09.042.

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22

Spruijt, Berry M., and Leonie DeVisser. "Advanced behavioural screening: automated home cage ethology." Drug Discovery Today: Technologies 3, no. 2 (2006): 231–37. http://dx.doi.org/10.1016/j.ddtec.2006.06.010.

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23

Terry, Stéphane, Céline Gommet, Anne-Cécile Kerangueven, et al. "Activity in Group-Housed Home Cages of Mice as a Novel Preclinical Biomarker in Oncology Studies." Cancers 15, no. 19 (2023): 4798. http://dx.doi.org/10.3390/cancers15194798.

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Background: Improving experimental conditions in preclinical animal research is a major challenge, both scientifically and ethically. Automated digital ventilated cages (DVC®) offer the advantage of continuous monitoring of animal activity in their home-cage. The potential utility of this technology remains understudied and deserves investigation in the field of oncology. Methods: Using the DVC® platform, we sought to determine if the continuous assessment of locomotor activity of mice in their home cages can serve as useful digital readout in the monitoring of animals treated with the referen

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Weber, Elin M., Josefina Zidar, Birgit Ewaldsson, et al. "Aggression in Group-Housed Male Mice: A Systematic Review." Animals 13, no. 1 (2022): 143. http://dx.doi.org/10.3390/ani13010143.

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Aggression among group-housed male mice is a major animal welfare concern often observed at animal facilities. Studies designed to understand the causes of male mice aggression have used different methodological approaches and have been heterogeneous, using different strains, environmental enrichments, housing conditions, group formations and durations. By conducting a systematic literature review based on 198 observed conclusions from 90 articles, we showed that the methodological approach used to study aggression was relevant for the outcome and suggested that home cage observations were bet

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Koot, S., W. Adriani, L. Saso, R. van den Bos, and G. Laviola. "Home cage testing of delay discounting in rats." Behavior Research Methods 41, no. 4 (2009): 1169–76. http://dx.doi.org/10.3758/brm.41.4.1169.

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KIM, Choong-Yong, and Sang-Seop HAN. "CHARACTERISTICS OF HOME CAGE LOCOMOTION IN CYNOMOLGUS MONKEYS." Journal of Toxicological Sciences 31, no. 5 (2006): 529–35. http://dx.doi.org/10.2131/jts.31.529.

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Patterson-Kane, E. G., M. Hunt, and D. Harper. "Rats Demand Social Contact." Animal Welfare 11, no. 3 (2002): 327–32. http://dx.doi.org/10.1017/s0962728600024908.

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AbstractThere is some evidence that rats benefit from social housing and from some forms of environmental enrichment, such as platforms and shelters. It is less clear whether they benefit from more spacious cages. There is a lack of information about the relative benefits of social contact, enrichment and increased space, because existing studies tend to concentrate on only one of these variables at a time. The current experiment used economic demand procedures as a method to compare, on a single scale, qualitatively different environments with a standard home cage. The data indicate that rats

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Stryjek, Rafał. "Devices for handling small mammals in laboratory conditions." Acta Neurobiologiae Experimentalis 68, no. 3 (2008): 407–13. http://dx.doi.org/10.55782/ane-2008-1707.

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Wild rodents, and especially rats, are significantly more difficult to handle, maintain and breed than laboratory rats and mice. They can be characterized as more skittish, neophobic and aggressive. While establishing a breeding colony of wild Norwegian rats (Rattus norvegicus) I developed some helpful devices and I will describe them here. In this paper I also describe the techniques for transporting animals between their home cages, separating them inside cages, and catching individuals that escape. These devices do not require any home cage modification. They may be modified for size. With

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Hinderliter, Charles F., and James R. Misanin. "Context Familiarity and Delayed Conditioned Taste Aversion in Young-Adult and Old-Age Rats." Perceptual and Motor Skills 77, no. 3_suppl (1993): 1403–6. http://dx.doi.org/10.2466/pms.1993.77.3f.1403.

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Familiarity with a conditioning context different from the home-cage environment was examined in immediate and delayed (3-hr.) conditioned taste aversion (CTA) learning for young-adult (90—120 days) and old-age (680—750 days) female Wistar albino rats. Context familiarity increased CTA for young adults at the 3-hr. delay. Old-age rats showed no aversion at 3-hr. delays. Results suggest that home-cage cues may be used in mediating long-delay CTA and that the role of these cues may differ with age.

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Sherwin, C. M., and E. F. Glen. "Cage colour preferences and effects of home cage colour on anxiety in laboratory mice." Animal Behaviour 66, no. 6 (2003): 1085–92. http://dx.doi.org/10.1006/anbe.2003.2286.

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31

Spangenberg, E., K. Dahlborn, B. Essén-Gustavsson, and K. Cvek. "Effects of physical activity and group size on animal welfare in laboratory rats." Animal Welfare 18, no. 2 (2009): 159–69. http://dx.doi.org/10.1017/s0962728600000300.

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AbstractThe aim of this study was to investigate whether moderate physical activity and group size influence physical fitness, the level of social interactions in the home cage and rats’ performance in the Elevated Plus Maze and a handling test. Forty-eight male Sprague Dawley rats were kept in groups of two, four or eight for seven weeks in cages adjusted to the group size. Home cage social interactions were studied during direct observations. Half of the number of rats from each cage were subjected to moderate exercise on a treadmill for five weeks. An exercise test was performed at the begi

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Ceccarelli, Francesco, Fabrizio Londei, Giulia Arena, Aldo Genovesio, and Lorenzo Ferrucci. "Home-Cage Training for Non-Human Primates: An Opportunity to Reduce Stress and Study Natural Behavior in Neurophysiology Experiments." Animals 15, no. 9 (2025): 1340. https://doi.org/10.3390/ani15091340.

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Research involving non-human primates remains a cornerstone in fields such as biomedical research and systems neuroscience. However, the daily routines of laboratory work can induce stress in these animals, potentially compromising their well-being and the reliability of experimental outcomes. To address this, many laboratories have adopted home-cage training protocols to mitigate stress caused by routine procedures such as transport and restraint—a factor that can impact both macaque physiology and experimental validity. This review explores the primary methods and experimental setups employe

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Burn, CC, J. Raffle, and JK Bizley. "Does 'playtime' reduce stimulus-seeking and other boredom-like behaviour in laboratory ferrets?" Animal Welfare 29, no. 1 (2020): 19–26. http://dx.doi.org/10.7120/09627286.29.1.019.

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Much environmental enrichment for laboratory animals is intended to enhance animal welfare and normalcy by providing stimulation to reduce 'boredom'. Behavioural manifestations of boredom include restless sensation-seeking behaviours combined with indicators of sub-optimal arousal. Here, we explored whether these signs could be reduced by extra daily play opportunity in laboratory ferrets (Mustela putorius furo). Specifically, we hypothesised that playtime would reduce restlessness, aggression, sensation-seeking and awake drowsiness, even 24 h later in the home-cage. Female ferrets (n = 14) we

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Drevet, Sabine, Bertrand Favier, Emmanuel Brun, Gaëtan Gavazzi, and Bernard Lardy. "Mouse Models of Osteoarthritis: A Summary of Models and Outcomes Assessment." Comparative Medicine 72, no. 1 (2022): 3–13. http://dx.doi.org/10.30802/aalas-cm-21-000043.

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Osteoarthritis (OA) is a multidimensional health problem and a common chronic disease. It has a substantial impact on patient quality of life and is a common cause of pain and mobility issues in older adults. The functional limitations, lack of curative treatments, and cost to society all demonstrate the need for translational and clinical research. The use of OA models in mice is important for achieving a better understanding of the disease. Models with clinical relevance are needed to achieve 2 main goals: to assess the impact of the OA disease (pain and function) and to study the efficacy o

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Barabas, Amanda J., Ronald A. Conlon, and Craig A. Hodges. "Think Beyond the Room: Measuring Relative Humidity in the Home Cage and Its Impact on Reproduction in Laboratory Mice, Mus musculus." Animals 14, no. 22 (2024): 3164. http://dx.doi.org/10.3390/ani14223164.

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Relative humidity (RH) is measured in vivaria with a broad range to accommodate seasonal fluctuations. It is assumed that measurements in the room (macroenvironment) reflect those in the cage (microenvironment). However, there is limited data comparing RH in the macroenvironment to the microenvironment and how the mice may be affected by variations in RH that fall within husbandry recommendations. This study aimed to compare RH in the macroenvironment to that of the microenvironment in various group sizes of laboratory mice; and examine how variation in microenvironmental RH impacts pup surviv

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Kahnau, Pia, Anne Jaap, Birk Urmersbach, Kai Diederich, and Lars Lewejohann. "Development of an IntelliCage-based cognitive bias test for mice." Open Research Europe 2 (November 25, 2022): 128. http://dx.doi.org/10.12688/openreseurope.15294.1.

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The cognitive bias test is used to measure the emotional state of animals with regard to future expectations. Thus, the test offers a unique possibility to assess animal welfare with regard to housing and testing conditions of laboratory animals. So far, however, performing such a test is time-consuming and requires the presence of an experimenter. Therefore, we developed an automated and home-cage based cognitive bias test based on the IntelliCage system. We present several developmental steps to improve the experimental design leading to a successful measurement of cognitive bias in group-ho

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Kahnau, Pia, Anne Jaap, Birk Urmersbach, Kai Diederich, and Lars Lewejohann. "Development of an IntelliCage-based cognitive bias test for mice." Open Research Europe 2 (August 8, 2023): 128. http://dx.doi.org/10.12688/openreseurope.15294.2.

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The cognitive bias test is used to measure the emotional state of animals with regard to future expectations. Thus, the test offers a unique possibility to assess animal welfare with regard to housing and testing conditions of laboratory animals. So far, however, performing such a test is time-consuming and requires the presence of an experimenter. Therefore, we developed an automated and home-cage based cognitive bias test based on the IntelliCage system. We present several developmental steps to improve the experimental design leading to a successful measurement of cognitive bias in group-ho

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O’Connor, Patricia E. "The prison cage as home for African American men." Journal of African American Men 6, no. 1 (2001): 71–86. http://dx.doi.org/10.1007/s12111-001-1015-1.

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Singh, Surjeet, Edgar Bermudez-Contreras, Mojtaba Nazari, Robert J. Sutherland, and Majid H. Mohajerani. "Low-cost solution for rodent home-cage behaviour monitoring." PLOS ONE 14, no. 8 (2019): e0220751. http://dx.doi.org/10.1371/journal.pone.0220751.

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Nasu, Makoto, Keiiti Anan, Yukiko Abe, Naoyuki Kozuki, Aya Matsushima, and Shintaroh Ueda. "Reduced home cage and social activity in Pou3f2⊿ mice." Biochemical and Biophysical Research Communications 523, no. 2 (2020): 411–15. http://dx.doi.org/10.1016/j.bbrc.2019.12.039.

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Hernadi, Zsófia, Leatitia Adlan, Gabriella Kékesi, Alexandra Büki, Gabor Tuboly, and Gyöngyi Horvath. "PERSONALIZED BEHAVIORAL ANALYSIS OF RODENTS IN HOME-CAGE CONDITION." IBRO Neuroscience Reports 15 (October 2023): S579. http://dx.doi.org/10.1016/j.ibneur.2023.08.1146.

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Baran, Szczepan W., Maria A. Lim, Johnny P. Do, et al. "Digital Biomarkers Enable Automated, Longitudinal Monitoring in a Mouse Model of Aging." Journals of Gerontology: Series A 76, no. 7 (2021): 1206–13. http://dx.doi.org/10.1093/gerona/glab024.

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Abstract To understand the growing needs of an aging human population, there is demand for scalable and reproducible approaches to study animal models of aging and to test novel therapeutic interventions. We investigated the sensitivity and utility of a continuous monitoring platform and its digital biomarkers (motion, breathing rate, and wheel running) to evaluate behavioral and physiological differences between “young” (12 weeks) and “old” (23 months) male C57BL/6J mice with or without running wheels in the home cage. Compared to young mice, old mice showed marked reductions in motion and br

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Smit, Alexia. "Engaging the senses: Dirt, food and the home." Short Film Studies 3, no. 1 (2012): 89–92. http://dx.doi.org/10.1386/sfs.3.1.89_1.

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Through its sensual and tactile evocation of dirt, eating and touching, The Cage produces an atmosphere of domestic intimacy and confinement which is disrupted by the appearance of a sick bird. This article explores how Mihaes' shift from initial disgust to a surprising tenderness is revealed in embodied terms.

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Yuan, Yaya, Ya-Qun Wang, Guilin Zhuang, et al. "Supporting a Cu@In₂O₃ core–shell structure on N-doped graphitic carbon cuboctahedral cages for efficient photocatalytic homo-coupling of terminal alkynes." Journal of Materials Chemistry A 9, no. 44 (2021): 24909–14. http://dx.doi.org/10.1039/d1ta08075j.

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Smith, F. G., J. E. Fewell, and I. Abu-Amarah. "Endocrine effects of pregnancy and exposure to a simulated open field in rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 273, no. 3 (1997): R1053—R1057. http://dx.doi.org/10.1152/ajpregu.1997.273.3.r1053.

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In adult rats, exposure to a novel environment, such as a simulated open field, elicits an increase in body core temperature. We have recently shown that this response is attenuated in midpregnancy and abolished at term of pregnancy in rats. We postulated that this gestation-dependent response resulted from alterations in the hypothalamic-pituitary-adrenal axis. To test this hypothesis, we measured the effects of pregnancy on renin, corticosterone, and arginine vasopressin (AVP) responses to exposure to either a simulated open field (30 or 120 min) or to the home cage (30 or 120 min) in rats.

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Hinderliter, Charles F., and James R. Misanin. "Age Differences and the Interstimulus Interval Context in Long-Delay Taste-Aversion Conditioning of Rats." Psychological Reports 76, no. 2 (1995): 636–38. http://dx.doi.org/10.2466/pr0.1995.76.2.636.

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Young-adult and old-adult rats were allowed to remain in the conditioning context or were returned to their home cages during a 3-hr. interval to assess whether previously observed age differences in long-delay taste-aversion conditioning may be due to age differences in the use of home-cage cues to mediate the CS-US association over a long delay. The old adults but not the young adults showed an aversion irrespective of the context in which they were detained during the interstimulus interval. These results suggest that young-adult rats do not use the interstimulus context cues to mediate the

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DE VOS, Gerrit J., and Hendrik S. VAN KAMPEN. "Memory for the Spatial Position of an Imprinting Object in Junglefowl Chicks." Behaviour 122, no. 1-2 (1992): 26–40. http://dx.doi.org/10.1163/156853992x00282.

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AbstractThe characteristics of memory for the position of an imprinting object were investigated in junglefowl chicks (Gallus gallus spadiceus). Subjects were exposed individually and continuously to an imprinting object located in one of the two back quadrants of their home cage ('training quadrant'). Positioning of chicks in a test cage was studied from 7 to 1 days after hatching. In experiment 1 chicks preferred the training quadrant over the other back quadrant when tested in an empty cage, but not when two identical training objects were present, one in each back quadrant. In tests with o

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Kõiv, Kadri, Denis Matrov, Trine Uusen, and Jaanus Harro. "Effect of Neuropeptide S Administration on Ultrasonic Vocalizations and Behaviour in Rats with Low vs. High Exploratory Activity." Pharmaceuticals 14, no. 6 (2021): 524. http://dx.doi.org/10.3390/ph14060524.

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Neuropeptide S (NPS) is a peptide neurotransmitter that in animal studies promotes wakefulness and arousal with simultaneous anxiety reduction, in some inconsistency with results in humans. We examined the effect of NPS on rat ultrasonic vocalizations (USV) as an index of affective state and on behaviour in novel environments in rats with persistent inter-individual differences in exploratory activity. Adult male Wistar rats were categorised as of high (HE) or low (LE) exploratory activity and NPS was administered intracerebroventricularly (i.c.v.) at a dose of 1.0 nmol/5 µL, after which USVs

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Theil, Jacob H., Jamie Ahloy-Dallaire, Elin M. Weber, et al. "The epidemiology of fighting in group-housed laboratory mice." Scientific Reports 10, no. 1 (2020). http://dx.doi.org/10.1038/s41598-020-73620-0.

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Abstract Injurious home-cage aggression (fighting) in mice affects both animal welfare and scientific validity. It is arguably the most common potentially preventable morbidity in mouse facilities. Existing literature on mouse aggression almost exclusively examines territorial aggression induced by introducing a stimulus mouse into the home-cage of a singly housed mouse (i.e. the resident/intruder test). However, fighting occurring in mice living together in long-term groups under standard laboratory housing conditions has barely been studied. We performed a point-prevalence epidemiological su

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Bohn, Lena, Louisa Bierbaum, Niklas Kästner, et al. "Structural enrichment for laboratory mice: exploring the effects of novelty and complexity." Frontiers in Veterinary Science 10 (September 29, 2023). http://dx.doi.org/10.3389/fvets.2023.1207332.

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Providing structural enrichment is a widespread refinement method for laboratory rodents and other animals in captivity. So far, animal welfare research has mostly focused on the effect of increased complexity either by accumulating or combining different enrichment items. However, increasing complexity is not the only possibility to refine housing conditions. Another refinement option is to increase novelty by regularly exchanging known enrichment items with new ones. In the present study, we used pair-housed non-breeding female C57BL/6J and DBA/2N mice to investigate the effect of novelty wh

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