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1
Aabel, S., S. Fossheim, and F. Rise. "Nuclear magnetic resonance (NMR) studies of homeopathic solutions." British Homeopathic Journal 90, no. 01 (January 2001): 14–20. http://dx.doi.org/10.1054/homp.1999.0458.
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AbstractThe efficacy of homeopathy is controversial. Nuclear magnetic resonance (NMR) has been used to study homeopathic solutions, showing provocative results. We examined the reproducibility of one of the allegedly positive studies. 1H NMR spectra were recorded for Sulphur D4, diluted and succussed up to D30 (called potentization) at two different frequencies (300 and 500 MHz). The Sulphur solution had been potentiated according to homeopathic principles with deionized water and alcohol. Water proton T1 relaxation measurements were performed also at 20 MHz for the different potentiated Sulphur solutions. Furthermore, the homeopathic remedy Betula alba 30c (birch pollen extract) and appropriate control solution (deionized water, unsuccussed solutions and placebo globules) were measured analogously, both with frequencies giving spectra and T1 relaxometry.The Sulphur remedies showed identical one dimensional proton spectra (1H NMR) at 300 and 500 MHz, regardless of dilution/succussion stage, from D4 to D30. Furthermore, Betula 30c as a potentiated solution and its controls (ethanol dilutions and Betula diluted but not succussed) showed identical spectra. Nor were there any statistically significant differences in longitudinal (T1) relaxation times between deionized water and Sulphur D10 to D30 preparations. The shorter T1 of the Sulphur D4 preparation could be ascribed to the higher microviscosity within the sample matrix caused by the high concentration of dissolved material. Also, the T1 values of the Betula alba 30c preparation (in globular form) and control placebo globules were identical.In conclusion, published results from NMR research on homeopathy indicating differences between homeopathic solutions and control samples could not be reproduced.
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Pinheiro, Mariana Santos, Paula Fernandes de Aguiar, Carla Holandino Quaresma, and Sheila Garcia. "Validation of impregnation process for homeopathic globules by spectrophotometric-UV method." Brazilian Journal of Pharmaceutical Sciences 50, no. 1 (March 2014): 137–46. http://dx.doi.org/10.1590/s1984-82502011000100014.
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We compared the impregnation techniques for globules according to the Manual of Technical Norms for Homeopathic Pharmacies (MNTFH) of the Association of Homeopathic Pharmacists (ABFH), Brazilian Homeopathic Pharmacopoeia (FHB) and variations of these techniques. The variables were evaluated in this procedure, three different sizes of globules (N o . 3, 5 and 7), the hydroalcoholic solution of 70% (v/v) Minoxidil 2% (w/v) was used to impregnate the globules in concentrations of 2, 3, 4, 5% (v/w) and the impregnation at 10 %(v/w) was used hydroalcoholic solutions at 70, 80 and 90% (v/v), and four impregnation techniques various ( A -glass, B -paper, C -cup and D -FHB). As the results of content uniformity did not demonstrate a normal distribution, the one way ANOVA and a nonparametric statistical model were used for evaluation. Considering the average, the standard deviation (SD), the individual variance of each group and the principal components analysis graphs (PCA), it was observed that the “A” impregnation of globules technique, with 5% (v/w) of the impregnation concentrations and the No.5 globule presented the best uniformity of dose. As to the drying, there was a need to use a heat source.
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Achstetter, Katharina, and Michael Teut. "Use of Self-Medication with Homeopathy in Germany: Results of an Online Questionnaire Survey." Complementary Medicine Research 25, no. 6 (2018): 383–90. http://dx.doi.org/10.1159/000485077.
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Background: Little is known about self-medication with homeopathic drugs in Germany. The aim of this study was to gain information about users, sources of information and the selection process of the drugs. Methods: An online questionnaire survey among users of self-medication with homeopathy was conducted via social media and email newsletters. Results: A total of 665 users who responded to the questionnaire were included. Most of the respondents were women (92%) in their mid-forties with high educational status. In total, 43% of the participants reported a household member working in the health sector. Books (65%) and Internet (47%) were the most common sources of information. Consultations in pharmacies - with a mean duration of 10 min - were likely to be used (60%). Homeopathic drugs were mainly used in the potency D12 (55%), for a duration of 5 days, 3 times daily, with 5 globules. Homeopathic drugs were mainly used due to good therapeutic experiences in the past (82%). Indications for use were acute diseases (91%), particularly colds (86%), as well as chronic diseases (51%) and prevention (47%). The selection of a homeopathic drug took the participants 25 min on average. Conclusion: Homeopathic self-medication is understood by users as a resource to regain, maintain, and promote health. Further research about the quality and applicability of information for homeopathic self-medication is necessary.
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Scardoeli, Bruna, Francine Brait Narita, Sônia Regina Pinheiro, Adalberto Von Ancken, and Cidéli de Paula Coelho. "Homeopathic Treatment of Trauma, Abscess and Papillomatosis in Trachemys dorbigni." International Journal of High Dilution Research - ISSN 1982-6206 18, no. 02 (June 30, 2021): 04. http://dx.doi.org/10.51910/ijhdr.v18i02.985.
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Background Mechanical trauma, bacterial and viral infections are common in Trachemys dorbigni when in captivity. Aims Report the evolution of homeopathic treatment in a patient of Trachemys dorbigni species. Methodology Homeopathic treatment was chosen, based on the principle of similitude, using Arnica montana due to its anti-inflammatory action, Avena sativa for the physical fatigue; Silicea to act in suppurative processes and Thuya occidentalis in papillomatosis. Results On 22/11/2018, with 1 month old, 6g, it presented lethargy, hyporexia, locomotor difficulty due to edema and necrotic process in the right anterior limb, presenting bad prognosis and possible limb loss. The protocol was 2 globules of Arnica montana 6CH, diluted in the contact water, every 8 hours, for 7 days and 2 globules of Avena sativa 6CH, every 12 hours, for 5 days. After 7 days, it was observed that the patient was active, normoretic, with weight gain and decreased edema and necrotic process of the right anterior limb, ruling out the amputation. On 29/12/2018, the patient presented a rigid abscess in the right cervical region, that adopted protocol with a single dose of 2 globules of Silicea 6CH and 2 globules of Arnica montana 6CH, diluted in the contact water, every 24 hours, for 4 days, until the return on 02/01/2019, with the complete regression. On 13/01/2019, it presented papillomas and plastron infection, which the proposed treatment was constituted with administration of 2 globules of Thuya occidentalis 12CH, diluted in the contact water, every 24 hours for 3 days, with total remission of the lesions occurring in 3 days. Conclusion Mechanical trauma, bacterial and viral infections can be controlled by homeopathic medicaments without the administration of antibiotic or surgeries, being fast, less harmful and with an affordable economic value.
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Baschin, Marion. "‘Globules at Home’: The History of Homeopathic Self-medication." Social History of Medicine 29, no. 4 (December 21, 2014): 717–33. http://dx.doi.org/10.1093/shm/hku074.
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Klein, Sabine D., and Ursula Wolf. "Investigating Homeopathic Verum and Placebo Globules with UV Spectroscopy." Forschende Komplementärmedizin / Research in Complementary Medicine 20, no. 4 (2013): 295–97. http://dx.doi.org/10.1159/000354408.
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Souza, Fernanda Santos de, Mayara Marin Pirolli, Eliana Elisabeth Diehl, and Diva Sonaglio. "Study of the variables which influence the impregnation of globules, compressed tablets and tablet triturates used in homeopathy." Brazilian Journal of Pharmaceutical Sciences 48, no. 3 (September 2012): 537–45. http://dx.doi.org/10.1590/s1984-82502012000300021.
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Globules, compressed tablets and tablet triturates are solid dosage forms used in homeopathy. Divergences can be noted between the preparation techniques described in official compendiums as well as those applied in homeopathic pharmacies. The difficulty associated with standardization of the impregnation of these dosage forms occurs due to the lack of detail provided for the techniques in the literature, leaving it up to each pharmacy to decide on the exact method of preparation. The objective was to optimize the impregnation technique, through investigating the variables that influence the impregnation of globules, compressed tablets and tablet triturates, applying the statistical tool of factorial design. The independent variables were the dosage form, percentage and type of impregnation and drying temperature, and the dependent variables were the mass gain, disintegration time, friability and hardness. For the globules, the greatest mass gain was for 10% impregnation and drying at 20 ºC. For the tablet triturates and compressed tablets the greatest mass gain was for 15% impregnation and there was no difference between the results obtained using simple and triple impregnation or different drying temperatures. The results can contribute to improving the final product quality, besides aiding in the establishment of standardized techniques for the official compendiums.
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Coelho, Cideli de Paula, Amanda do C. Souza, Victoria Arrifano, Flora Cordeiro, and Maria Martha Bernardi. "Testicle histomorphometry in senescence/senility under use of homeopathy." International Journal of High Dilution Research - ISSN 1982-6206 17, no. 1 (July 22, 2021): 20. http://dx.doi.org/10.51910/ijhdr.v17i1.904.
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Aging is an extremely complex and multifactorial process. Over time, the elderly begin exhibiting signs of function reduction. The aim of the present study was to assess the effects of homeopathic medicines on testicle histomorphometry in senescence/senility. The study was approved by the animal experimentation ethics committee of Santo Amaro University (07/2015). The rats (Wistar, all male, with 22-23 months of age were used) were caged with access to food and water ad libitum and 12-hour light cycle (7:00 am to 7:00 pm). The homeopathic medicines were prepared following the Brazilian Homeopathic Pharmacopoeia. The animals were randomly distributed in 4 groups (n= 6): control; hydroalcoholic solution; Calcarea carbonica 30cH (Calc) and Baryta muriatica 30cH (Bar-m). 5 globules of the medicines were added to each water dispenser; the containers were changed twice per week along 40 days. All investigators were blinded to the allocation groups. After 40 days all the animals were euthanized and the testicles collected. Based on their width and length, the testicles’ volume was calculated by means of the ellipsoid formula. Slides were prepared and stained with PAS. Photographs were taken of the slides with 40x magnification under microscope; software Image J was used to measure the diameter of 50 seminiferous tubules per slide (animal), diameter of the parenchyma and lumen of each tubule. Statistical analysis was performed by means of ANOVA followed by Tukey’s test; the significance level was set to p≤ 0.05. Increase of the testicles’ volume, increased parenchymal diameter and decrease of the tubular lumen was found in groups Calc and Bar-m compared to controls and the group treated with hydroalcoholic solution (p ≤ 0.05). We conclude that the tested homeopathic medicines changed the testicle histomorphometry of animals in senescence/senility.
Keywords: Testicular histomorphometry, homeopathy, Calcarea carbonica, Baryta muriatica, Senescence/Senility
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Hanif, Asma, and Shahnaz Dawar. "Comparative Studies Using Homeopathic Globules for Leguminous and Non-Leguminous Crop Management against Root Rot Fungi." Journal of Agricultural Science 8, no. 9 (August 5, 2016): 205. http://dx.doi.org/10.5539/jas.v8n9p205.
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<p>The aim of this study was to assess fungicidal potential of homeopathic globules namely <em>Thuja occidentalis</em> and <em>Arnica montana</em> (30C) on plant growth and root infecting fungi particularly <em>Rhizoctonia solani</em>,<em> Fusarium</em> spp. and <em>Macrophomina phaseolina.</em> Both <em>in vitro</em> and <em>in vivo</em> experiments had found positive results in the suppression of root rot fungi. Investigation on present study showed that <em>A. montana</em> and <em>T. occidentalis</em> globules (100, 75 and 50% v/w concentrations) reduced disease intensity caused by root rot pathogens and improved growth of test plants, but it produces negative effects on leguminous test crops in which nodules were failing to produce.</p>
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Hossain, MG, MG Haider, MR Khan, EH Chowdhury, and MM Hossain. "IN VIVO INVESTIGATION OF BOVINE CUTANEOUS PAPILLOMATOSIS WITH HOMEOPATHIC PREPARATIONS." Bangladesh Journal of Veterinary Medicine 3, no. 2 (July 23, 2012): 114–16. http://dx.doi.org/10.3329/bjvm.v3i2.11370.
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This investigation was carried out to determine the effects of thuza and antim crud (Homeopathic preparations) on bovine cutaneous papillomatosis/wart. Nine calves of one to two and a half years age and of both sexes affected with cutaneous papillomatosis were randomly divided into three equal groups (group I, group II and group III) for this experiment from March 2002 to February 2003. Each calf of group I was first administered with 15 globules sulphur with a potency of 200-power once orally. This was followed after 7 days with 50M (M = 1000-power) thuza at the dose rate of 10 globules twice daily orally for a period of three weeks. The calves of group II were administered with sulphur and antim crud at the same dose, potency, route and duration, respectively and the calves of group III were kept as untreated control. Papilloma tissues were collected prior to treatment and at the sixth week of treatment and they were subjected to histopathological examination. Thuza and antim crud with concurrent use of sulphur were found effective in curing bovine cutaneous papillomatosis with a rate of 66.66% (4/6). Little or no reduction in size of the papillomas was observed within the first two weeks of treatment in both the treated groups (group I and group II). Thereafter, miniature size sessile and pedunculated papillomas started drying with the gradual reduction in size that fell leaving hairless areas at the end of fourth week. By the eighth week there was complete cure of papillomas. One calf of each treated groups (group I and group II) affected with large papillomas (5 X 7 cm) were not completely cured. Microscopic examination of regressive papillomas at sixth week of treatment showed cellular necrosis. Growth recurrence was not observed within one month of recovery. In the untreated control group (group III), the number and size of papillomas increased. Therefore, this line of treatment may be practiced for the treatment of bovine papillomatosis.
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Scardoeli, Bruna, Natália José Aith, Adalberto Von Ancken, and Cidéli Paula Coelho. "Treatment of severe thrombocytopenia with platelet biotherapic and Phosphorus." International Journal of High Dilution Research - ISSN 1982-6206 18, no. 02 (June 30, 2021): 13. http://dx.doi.org/10.51910/ijhdr.v18i02.993.
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Background Thrombocytopenia is a decrease in the number of platelets in the blood resulting from disorders of production, distribution or destruction, leading to bleeding. The respective treatment of thrombocytopenia is usually based on corticotherapy and platelet transfusion. Aims Report the evolution of homeopathic treatment in a 12 years old Maltese canine cardiopathic patient with thrombocytopenia associated with the diagnosis of Ehrlichia canis. Methods Replacement of corticoid and transfusion by Platelet Biotherapic, to stimulate platelet production and high diluted Phosphorus to contain the bleeding. Results On 01/28/19, the patient presented thrombocytopenia of 5.000/mm³ with large platelets, petechials and suffusion hemorrhages in dorsal and ventral regions, extensive acute cervical hematoma due to blood collection; anisocytosis, polychromasia and Howell Jolly corpuscle in red series; and also reactive lymphocytes, monocytes active and toxic neutrophils in white series. On 01/30/19, initiated the administration of 3 globules of Platelet Biotherapic 12CH every 12 hours; 3 globules of Phosphorus 6CH every 24 hours, both oral; and topical phytotherapeutic use of Arnica montana once daily. Three days later, it was observed the complete absence of petechials and suffusion hemorrhages, with elevation of platelets count to 74.000/mm³ and mild leukocytosis with improvement in overall patient well-being. On 02/06/19, there was regression of hematoma and leukocytosis, in addition to the platelet count in 95.000/mm³. On 02/14/19, due to slight decrease in platelets to 92.000/mm³, the frequency of Phosphorus 6CH was changed every 12 hours. On 02/20/19, the new platelet count reached 126.000/mm³ with standardized morphology and no Howell Jolly record. Conclusion The homeopathies (High dilution medicine) have proven to be successful in the treatment of thrombocytopenia without causing side effects.
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Klein, Sabine D., and Ursula Wolf. "Comparison of homeopathic globules prepared from high and ultra-high dilutions of various starting materials by ultraviolet light spectroscopy." Complementary Therapies in Medicine 24 (February 2016): 111–17. http://dx.doi.org/10.1016/j.ctim.2015.12.017.
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Lenger, K., R. P. Bajpai, and M. Drexel. "Delayed luminescence of high homeopathic potencies on sugar globuli." Homeopathy 97, no. 3 (July 2008): 134–40. http://dx.doi.org/10.1016/j.homp.2008.05.003.
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Deshmukh, C. K. I. "341. STUDY OF APHRODISIAC DRUG ACID PHOS ON MALE ALBINO RAT." Reproduction, Fertility and Development 22, no. 9 (2010): 141. http://dx.doi.org/10.1071/srb10abs341.
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The male albino rat, Rattus norvegicus maintained in the laboratory by supplying regularly food and water. Acid phos is a well known aphrodisiac drug from homeopathy medical system. Doses of 200 gm of 30 number globules made from sugar of milk and moistened by 15 mL of acid phos (H3PO3) of 6 potency. Group-I, II and III experimental rats were carried out for 15, 30, and 15 day recovery period respectively. Appreciable behavioral changes and changes in the body weights were noticed. In 15, 30 and in 15 days of recovery period, the acid phosphatase, SGOT and albumin were significant (P < 0.05) while alkaline phosphatase, SGPT, cholesterol, glucose, total proteins and globulin was found non-significant but A:G ratio was increasedsignificantly in 30 days of treatment. The weight of liver, kidney, and testis has found linear increased relationship with the body weight but significant (P < 0.050) increased in the weight of seminal vesicle and body weight in the experimental rat. Various histo-architectural changes were observed in the tissues of liver, kidney, testis and seminal vesicle. Both liver and kidney showed degenerative changes after 15 and 30 days .Tetraploid stages of liver pernchymal cells were predominant in the experimental rats while in 15 days of recovery period, both attained the recovery. In 30 days, the diameter of seminiferous tubules is markedly reduced, with thin unfolded mucosa. In 15 days of administration of acid phos, the intertubular spaces between the seminiferous tubule were also reduced. The number of spermatids was increased in recovery period, the testis showed the recovery. In 15 days of administration, the secretion in the lumen of seminal vesicles increased related with the structure of the epithelium of seminal vesicles while in 15 days of recovery period, the seminal vesicles showed recovery of secretory activities with pseudostratified epithelium. All the results are discussed detailed in paper.
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Баймишев, Мурат, Murat Baymishev, Хайдар Сафиуллин, Haydar Safiullin, Хамидулла Баймишев, Khamidulla Baymishev, Оксана Пристяжнюк, and Oksana Pristyazhnyuk. "THE EFFICIENCY OF DRUG TSIMAKTIN USING FOR THE PREVENTION OF COWS POSTPARTUM COMPLICATIONS." Bulletin Samara State Agricultural Academy 2, no. 3 (July 27, 2017): 46–50. http://dx.doi.org/10.12737/17454.
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The purpose of researches is rising of efficiency of prophylaxis of cows patrimonial and puerperal pathologies. The current of cows labors and the puerperal period when using homeopathic medicine is studied Tsimaktin. It is estab-lished that drug Tsimaktin use reduces duration of cows current of labors in comparison with control by 1.87 hours. An involution of body and horns of experienced group uterus animals came to the end for 11.35 days earlier. Dis-turbances of involutional processes of control group cows reproductive organs to whom use didn't administer the drug 20% more Tsimaktin than at animals of experienced group. It is taped that drug Tsimaktin raises the morpho-functional status of cows organism that is confirmed by hematological and biochemical indicators of blood. The hemoglobin content, erythrocytes in control group cows blood after calvin was reliable less, than indicators of ani-mals of experienced group respectively on 15.09 g/l and on 1.94 1012 l. The indicator of the general protein in blood serum of experienced group cows is 2.69 g/l more than at cows of control group. The quantity of β-globulins after the delivery are more for cows of control group in comparison with experienced for 7,33% that indicates existence of inflammatory process in an organism of animals. Control group cows for 4-5 day the atsidotichesk state was after the delivery observed what the smaller indicator of an alkaline reserve on 3.38 ob%CO2 testifies to. Use of homeopathic medicine Tsimaktin in 25-30 days prior to labors allowed to raise cows fecundity and to reduce the number of days of sterility. Use of this drug is ecologically safe and allows to use milk without restrictions. On the basis of the conducted researches drug Tsimaktin can be recommended for prophylaxis of puerperal complications at cows.
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Wolf, U., and S. Klein. "P01.32. Can homeopathic verum and placebo globules be distinguished by UV spectroscopy?" BMC Complementary and Alternative Medicine 12, S1 (June 2012). http://dx.doi.org/10.1186/1472-6882-12-s1-p32.
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Adler, Ubiratan Cardinalli, Maristela Schiabel Adler, Livia Mitchiguian Hotta, Ana Elisa Madureira Padula, Amarilys de Toledo Cesar, José Nelson Martins Diniz, Crislaine Aparecida Antonio Mestre, et al. "Homeopathy for Covid-19 in Primary Care: A structured summary of a study protocol for a randomized controlled trial." Trials 22, no. 1 (February 1, 2021). http://dx.doi.org/10.1186/s13063-021-05071-5.
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Abstract Objectives To investigate the effectiveness and safety of homeopathic medicine Natrum muriaticum (LM2) for mild cases of COVID-19 in Primary Health Care. Trial design A randomized, two-armed (1:1), parallel, placebo-controlled, double-blind, clinical trial is being performed to test the following hypotheses: H0: homeopathic medicines = placebo (null hypothesis) vs. H1: homeopathic medicines ≠ placebo (alternative hypothesis) for mild cases of COVID-19 in Primary Care. Participants Setting: Primary Care of São Carlos – São Paulo – Brazil. One hundred participants aged 18 years or older, with Influenza-like symptoms and a positive RT-PCR for SARS-CoV-2. Willingness to give informed consent and to comply with the study procedures is also required. Exclusion criterium: severe acute respiratory syndrome. Intervention and comparator Homeopathy: 1 globule of Natrum muriaticum LM2 diluted in 20 mL of alcohol 30% and dispensed in a 30 ml bottle. Placebo: 20 mL of alcohol 30% dispensed in a 30 ml bottle. Posology: one drop taken orally every 4 hours (6 doses/day) while there is fever, cough, tiredness, or pain (headache, sore throat, muscle aches, chest pain, etc.) followed by one drop every 6 hours (4 doses/day) until the fourteenth day of use. The bottle of study medication should be submitted to 10 vigorous shakes (succussions) before each dose. Posology may be changed by telemedicine, with no break in blinding. Study medication should be maintained during home isolation. According to the Primary Care protocol, the home isolation period lasts until the 10th day after the appearance of the first symptom, or up to 72 hours without symptoms. Main outcomes The primary endpoint will be time to recovery, defined as the number of days elapsed before all COVID-19 Influenza-like symptoms are recorded as mild or absent during home isolation period. Secondary measures are recovery time for each COVID-19 symptom; score of the scale created for the study (COVID-Simile Scale); medicines used during follow-up; number of days of follow-up; number of visits to emergency services; number of hospitalizations; other symptoms and Adverse Events during home isolation period. Randomisation The study Statistician generated a block randomization list, using a 1:1 ratio of the two groups (denoted as A and B) and a web-based tool (http://www.random.org/lists). Blinding (masking) The clinical investigators, the statistician, the Primary Care teams, the study collaborators, and the participants will remain blinded from the identity of the two treatment groups until the end of the study. Numbers to be randomised (sample size) One hundred participants are planned to be randomized (1:1) to placebo (50) or homeopathy (50). Trial Status Protocol version/date May 21, 2020. Recruitment is ongoing. First participant was recruited/included on June 29,2020. Due to recruitment adaptations to Primary Care changes, the authors anticipate the trial will finish recruiting on April 10, 2021. Trial registration COVID-Simile Study was registered at the University Hospital Medical Information Network (UMIN - https://www.umin.ac.jp/ctr/index.htm) on June 1st, 2020, and the trial start date was June 15, 2020. Unique ID: UMIN000040602. Full protocol The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.